ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures

Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene Expressed Sample Information
	Fusion Gene and Drug/Small Molecule Search from PubMed Abstracts
	Fusion Gene and Diseases from the Found PubMed Abstracts
	Fusion Gene and Diseases from Manual Curation and Other Resource
	Details of the Found Drugs/Small Molecules
	Clinical Trials of the Found Drugs/Small Molecules
	Fusion-Positive Patients' Treatment Records
	Generative AI Summary Sentence of the Relationship Between Fusion Gene and Small Molecule that Have at Least Thrree PMIDs from PubMed.

TMPRSS2::ERG

Fusion Gene Summary

Fusion Gene Summary

Fusion gene name: TMPRSS2-ERG
	Hgene	Tgene
Gene symbol	TMPRSS2	ERG
Gene ID	7113	2078
Gene name	transmembrane serine protease 2	ETS transcription factor ERG
Synonyms	PRSS10\|TMPRSS2	LMPHM14\|erg-3\|p55\|ERG
Cytomap	21q22.3	21q22.2
Type of gene	protein-coding	protein-coding
Description	transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2	transcriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 oncogene homologv-ets avian erythroblastosis
Modification date	20240407	20240323
UniProtAcc	.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMPRSS2	GO:0006508	proteolysis	21068237\|24227843
Hgene	TMPRSS2	GO:0046598	positive regulation of viral entry into host cell	21068237\|24227843\|32404436
Tgene	ERG	GO:0045944	positive regulation of transcription by RNA polymerase II	18195090\|23913826

Fusion Gene Expressed Sample Information

Fusion gene information from FusionGDB2.0 (ChiTars 5.0 and ChimerDB 4.0), COSMIC, and CCLE.

* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-2A-A8VL-01A	TMPRSS2	chr21	42866282	ERG	chr21	39844002
ChimerDB4	TCGA-2A-A8VL-01A	TMPRSS2	chr21	42866283	ERG	chr21	39817544
ChimerDB4	TCGA-2A-A8VL-01A	TMPRSS2	chr21	42866368	ERG	chr21	39817543
ChimerDB4	TCGA-2A-A8VL-01A	TMPRSS2	chr21	42866406	ERG	chr21	39817543
ChimerDB4	TCGA-2A-A8VT-01A	TMPRSS2	chr21	42880008	ERG	chr21	39817544
ChimerDB4	TCGA-2A-A8VV-01A	TMPRSS2	chr21	42870045	ERG	chr21	39881275
ChimerDB4	TCGA-2A-A8VV-01A	TMPRSS2	chr21	42870046	ERG	chr21	39817544
ChimerDB4	TCGA-CH-5752-01A	TMPRSS2	chr21	42879876	ERG	chr21	39846043
ChimerDB4	TCGA-CH-5765-01A	TMPRSS2	chr21	42878908	ERG	chr21	39817542
ChimerDB4	TCGA-CH-5768-01A	TMPRSS2	chr21	42880008	ERG	chr21	39956869
ChimerDB4	TCGA-CH-5769-01A	TMPRSS2	chr21	42870045	ERG	chr21	39846043
ChimerDB4	TCGA-CH-5769-11A	TMPRSS2	chr21	42870045	ERG	chr21	39817544
ChimerDB4	TCGA-CH-5789-01A	TMPRSS2	chr21	42866282	ERG	chr21	39846043
ChimerDB4	TCGA-CH-5789-01A	TMPRSS2	chr21	42866282	ERG	chr21	39859593
ChimerDB4	TCGA-CH-5789	TMPRSS2	chr21	42866283	ERG	chr21	39846044
ChimerDB4	TCGA-EJ-5497-01A	TMPRSS2	chr21	42870045	ERG	chr21	39859593
ChimerDB4	TCGA-EJ-5499-01A	TMPRSS2	chr21	42870045	ERG	chr21	39818130
ChimerDB4	TCGA-EJ-5502-01A	TMPRSS2	chr21	42860320	ERG	chr21	39895863
ChimerDB4	TCGA-EJ-5502-01A	TMPRSS2	chr21	42860320	ERG	chr21	39896851
ChimerDB4	TCGA-EJ-5502-01A	TMPRSS2	chr21	42860320	ERG	chr21	39899608
ChimerDB4	TCGA-EJ-5502-01A	TMPRSS2	chr21	42860321	ERG	chr21	39817544
ChimerDB4	TCGA-EJ-5512-01A	TMPRSS2	chr21	42878049	ERG	chr21	39870186
ChimerDB4	TCGA-EJ-5512-01A	TMPRSS2	chr21	42878372	ERG	chr21	39817544
ChimerDB4	TCGA-EJ-5522-01A	TMPRSS2	chr21	42871601	ERG	chr21	39956868
ChimerDB4	TCGA-EJ-5522-01A	TMPRSS2	chr21	42879876	ERG	chr21	39956868
ChimerDB4	TCGA-EJ-5522-01A	TMPRSS2	chr21	42880007	ERG	chr21	39966566
ChimerDB4	TCGA-EJ-5522-01A	TMPRSS2	chr21	42880007	ERG	chr21	39969016
ChimerDB4	TCGA-EJ-5524-01A	TMPRSS2	chr21	42871612	ERG	chr21	39817543
ChimerDB4	TCGA-EJ-7321-01A	TMPRSS2	chr21	42879876	ERG	chr21	39817543
ChimerDB4	TCGA-EJ-7783-01A	TMPRSS2	chr21	42879877	ERG	chr21	39817544
ChimerDB4	TCGA-EJ-7785-01A	TMPRSS2	chr21	42870674	ERG	chr21	39812988
ChimerDB4	TCGA-EJ-7785-01A	TMPRSS2	chr21	42878372	ERG	chr21	39795483
ChimerDB4	TCGA-EJ-7785-01A	TMPRSS2	chr21	42880007	ERG	chr21	39795482
ChimerDB4	TCGA-EJ-7785-01A	TMPRSS2	chr21	42880008	ERG	chr21	39795483
ChimerDB4	TCGA-EJ-8469-01A	TMPRSS2	chr21	42880012	ERG	chr21	39817548
ChimerDB4	TCGA-EJ-A46D-01A	TMPRSS2	chr21	42876948	ERG	chr21	39817542
ChimerDB4	TCGA-EJ-A8FO-01A	TMPRSS2	chr21	42870045	ERG	chr21	39844002
ChimerDB4	TCGA-G9-6342-01A	TMPRSS2	chr21	42865470	ERG	chr21	39873529
ChimerDB4	TCGA-G9-6356-01A	TMPRSS2	chr21	42879623	ERG	chr21	39817542
ChimerDB4	TCGA-G9-6362-01A	TMPRSS2	chr21	42872304	ERG	chr21	39852648
ChimerDB4	TCGA-G9-6363-11A	TMPRSS2	chr21	42880007	ERG	chr21	39817544
ChimerDB4	TCGA-G9-6377	TMPRSS2	chr21	42880008	ERG	chr21	39846044
ChimerDB4	TCGA-HC-7213-01A	TMPRSS2	chr21	42879624	ERG	chr21	39817543
ChimerDB4	TCGA-HC-7230-01A	TMPRSS2	chr21	42880007	ERG	chr21	39846043
ChimerDB4	TCGA-HC-7231-01A	TMPRSS2	chr21	42879500	ERG	chr21	39817543
ChimerDB4	TCGA-HC-7818-01A	TMPRSS2	chr21	42879877	ERG	chr21	39956869
ChimerDB4	TCGA-HC-8213-01A	TMPRSS2	chr21	42875331	ERG	chr21	39860754
ChimerDB4	TCGA-HC-8257-01A	TMPRSS2	chr21	42870046	ERG	chr21	39956869
ChimerDB4	TCGA-HC-8260-01A	TMPRSS2	chr21	42872206	ERG	chr21	39862257
ChimerDB4	TCGA-HC-A632-01A	TMPRSS2	chr21	42870045	ERG	chr21	39956868
ChimerDB4	TCGA-HC-A632-01A	TMPRSS2	chr21	42870045	ERG	chr21	39966566
ChimerDB4	TCGA-HC-A6HY-01A	TMPRSS2	chr21	42878734	ERG	chr21	39868732
ChimerDB4	TCGA-HC-A76X-01A	TMPRSS2	chr21	42868170	ERG	chr21	39869525
ChimerDB4	TCGA-HC-A76X-01A	TMPRSS2	chr21	42870045	ERG	chr21	39817543
ChimerDB4	TCGA-HC-A76X-01A	TMPRSS2	chr21	42880007	ERG	chr21	39817543
ChimerDB4	TCGA-J4-A67S-01A	TMPRSS2	chr21	42879499	ERG	chr21	39817542
ChimerDB4	TCGA-J4-A67T-01A	TMPRSS2	chr21	42880007	ERG	chr21	39947670
ChimerDB4	TCGA-J4-A67T-01A	TMPRSS2	chr21	42880007	ERG	chr21	39956868
ChimerDB4	TCGA-J4-A83K-01A	TMPRSS2	chr21	42879085	ERG	chr21	39833123
ChimerDB4	TCGA-J4-AATV-01A	TMPRSS2	chr21	42870046	ERG	chr21	39846044
ChimerDB4	TCGA-J9-A8CK-01A	TMPRSS2	chr21	42879877	ERG	chr21	39795483
ChimerDB4	TCGA-KK-A6DY-01A	TMPRSS2	chr21	42860320	ERG	chr21	39817543
ChimerDB4	TCGA-KK-A6DY-01A	TMPRSS2	chr21	42860320	ERG	chr21	39846043
ChimerDB4	TCGA-KK-A6DY	TMPRSS2	chr21	42860321	ERG	chr21	39846044
ChimerDB4	TCGA-KK-A6E4-01A	TMPRSS2	chr21	42878370	ERG	chr21	39817542
ChimerDB4	TCGA-KK-A7B4-01A	TMPRSS2	chr21	42870178	ERG	chr21	39874614
ChimerDB4	TCGA-KK-A8IA-01A	TMPRSS2	chr21	42870045	ERG	chr21	39863826
ChimerDB4	TCGA-KK-A8IH-01A	TMPRSS2	chr21	42865473	ERG	chr21	39839000
ChimerDB4	TCGA-KK-A8IH-01A	TMPRSS2	chr21	42866282	ERG	chr21	39795482
ChimerDB4	TCGA-MG-AAMC-01A	TMPRSS2	chr21	42879875	ERG	chr21	39817542
ChimerDB4	TCGA-QU-A6IN-01A	TMPRSS2	chr21	42870044	ERG	chr21	39817542
ChimerDB4	TCGA-QU-A6IN-01A	TMPRSS2	chr21	42870045	ERG	chr21	39817542
ChimerDB4	TCGA-VP-A87D-01A	TMPRSS2	chr21	42878371	ERG	chr21	39817543
ChimerDB4	TCGA-VP-A87D-01A	TMPRSS2	chr21	42878909	ERG	chr21	39817543
ChimerDB4	TCGA-VP-A87K-01A	TMPRSS2	chr21	42879876	ERG	chr21	39795482
ChimerDB4	TCGA-WB-A81K-01A	TMPRSS2	chr21	42870046	ERG	chr21	39795483
ChimerDB4	TCGA-X4-A8KQ-01A	TMPRSS2	chr21	42865040	ERG	chr21	39837582
ChimerDB4	TCGA-X4-A8KQ-01A	TMPRSS2	chr21	42866282	ERG	chr21	39817543
ChimerDB4	TCGA-X4-A8KQ	TMPRSS2	chr21	42866407	ERG	chr21	39817544
ChimerDB4	TCGA-XJ-A83F-01A	TMPRSS2	chr21	42870045	ERG	chr21	39795482
ChimerDB4	TCGA-YL-A8HK	TMPRSS2	chr21	42880008	ERG	chr21	39966567
ChiTaRS5.0	DQ204772	TMPRSS2	chr21	42880007	ERG	chr21	39817547
ChiTaRS5.0	DQ204773	TMPRSS2	chr21	42880006	ERG	chr21	39956872
ChiTaRS5.0	EF194202	TMPRSS2	chr21	42883789	ERG	chr21	39817546
COSMIC	1028868	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028869	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028870	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028871	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028872	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028873	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028874	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028875	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028876	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028877	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1028878	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1028879	TMPRSS2	chr21	42860321	ERG	chr21	39817544
COSMIC	1028880	TMPRSS2	chr21	42860321	ERG	chr21	39817544
COSMIC	1028881	TMPRSS2	chr21	42860321	ERG	chr21	39817544
COSMIC	1038772	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1038773	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1038774	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1038775	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1038776	TMPRSS2	chr21	42866283	ERG	chr21	39956869
COSMIC	1038777	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1038778	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1038779	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1038780	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1038781	TMPRSS2	chr21	42870046	ERG	chr21	39956869
COSMIC	1038782	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1038783	TMPRSS2	chr21	42870046	ERG	chr21	39956869
COSMIC	1038784	TMPRSS2	chr21	42866283	ERG	chr21	39956869
COSMIC	1038785	TMPRSS2	chr21	42870046	ERG	chr21	39956869
COSMIC	1038786	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1038787	TMPRSS2	chr21	42880008	ERG	chr21	39947671
COSMIC	1038788	TMPRSS2	chr21	42880008	ERG	chr21	39947671
COSMIC	1038789	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038790	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038791	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038792	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038793	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038794	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038795	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038796	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038797	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038798	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038799	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038800	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038801	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038802	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038803	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038804	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038805	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1038806	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	104_N	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	104_T	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063589	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1063590	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063591	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063592	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063593	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063594	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063595	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063596	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063597	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063598	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1063599	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	106_N	TMPRSS2	chr21	42866283	ERG	chr21	39956869
COSMIC	106_T	TMPRSS2	chr21	42870046	ERG	chr21	39956869
COSMIC	1070387	TMPRSS2	chr21	42870046	ERG	chr21	39956869
COSMIC	1070388	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070389	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070390	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070391	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070392	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070393	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1070394	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070395	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1070396	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070397	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070398	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070399	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1070402	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1070406	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1070407	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081125	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081126	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081127	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081128	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081129	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081130	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081131	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081132	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081133	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081134	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081135	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081136	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081137	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081138	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081139	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081140	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081141	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081142	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081143	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081144	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081145	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081146	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081147	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081148	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081149	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081150	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081151	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081152	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081153	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1081154	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1081155	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1081156	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1081157	TMPRSS2	chr21	42861434	ERG	chr21	39817544
COSMIC	1084940	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084941	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084942	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084943	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084944	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084945	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084946	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084947	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084948	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084949	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084950	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084951	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084952	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084953	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084954	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084955	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084956	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084957	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084958	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084959	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084960	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084961	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1084962	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1084963	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1084964	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1084965	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1084966	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1084967	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1084968	TMPRSS2	chr21	42870046	ERG	chr21	39956869
COSMIC	109_N	TMPRSS2	chr21	42870117	ERG	chr21	39817544
COSMIC	109_T	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	10	TMPRSS2	chr21	42870046	ERG	chr21	39956869
COSMIC	110_N	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1238759	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238760	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1238761	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238762	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238765	TMPRSS2	chr21	42870046	ERG	chr21	39947671
COSMIC	1238767	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238768	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238770	TMPRSS2	chr21	42870046	ERG	chr21	39947671
COSMIC	1238771	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238772	TMPRSS2	chr21	42870046	ERG	chr21	39947671
COSMIC	1238774	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238775	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238778	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238779	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1238782	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238783	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1238785	TMPRSS2	chr21	42870046	ERG	chr21	39947671
COSMIC	1242070	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242071	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242072	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242073	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242074	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242075	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242076	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242077	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242078	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242079	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242080	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242081	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1242082	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1242083	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1242084	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1242085	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1242086	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1242087	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1242088	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	124_NA	TMPRSS2	chr21	42870046	ERG	chr21	39795483
COSMIC	124_NN	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	124_T	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1305449	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305450	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305451	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305452	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305453	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305454	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305455	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305456	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305457	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1305458	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307710	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307711	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307713	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307716	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307718	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307719	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307720	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307721	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307722	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307724	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307725	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307727	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307728	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307736	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307739	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307742	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307744	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307745	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307748	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307749	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307751	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307752	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307756	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307757	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307760	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307761	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307765	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307766	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307767	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307768	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307769	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307770	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1307771	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307775	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307777	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307779	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307782	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307783	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307784	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1307792	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1307793	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	13_D	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	13	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	140_T	TMPRSS2	chr21	42880008	ERG	chr21	39947671
COSMIC	144-01	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	14	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	150	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545327	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545328	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545329	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545330	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545331	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545332	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545333	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545334	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545335	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545336	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545337	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545338	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545339	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545340	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545341	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545342	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545343	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545344	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545345	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545346	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545347	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545348	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545349	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545350	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545351	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545352	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545353	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545354	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545355	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545356	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545357	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545358	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545359	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545360	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545361	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545362	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545363	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545364	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545365	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545366	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545367	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545368	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545369	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545370	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545371	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545372	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545373	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545374	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545375	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545376	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545377	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545378	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545379	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1545380	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1548724	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1548726	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	154b_T	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	155_N	TMPRSS2	chr21	42866283	ERG	chr21	39817544
COSMIC	155_T	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	162_T	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	16	TMPRSS2	chr21	42866283	ERG	chr21	39817544
COSMIC	1700_D	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1701_A	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744854	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744855	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744856	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744857	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744858	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744859	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744860	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744861	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744862	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744863	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744864	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744865	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744866	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744867	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744868	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744869	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744870	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744871	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744872	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744873	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744874	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744875	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744876	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744877	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744878	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744879	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744880	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744881	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744882	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744883	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744884	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744885	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744886	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744887	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744888	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744889	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744890	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744891	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744892	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744893	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744894	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744895	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744896	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744897	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744898	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744899	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744900	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744901	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744902	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744903	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744904	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744905	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744906	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744907	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744908	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744909	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744910	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744911	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744912	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744913	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744914	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744915	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744916	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744917	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744918	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744919	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744920	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744921	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744922	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744923	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744924	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744925	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744926	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744927	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744928	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744929	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744930	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744931	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744932	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744933	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744934	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744935	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744936	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744937	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744938	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744939	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744940	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744941	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744942	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744943	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744944	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744945	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744946	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744947	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744948	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744949	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744950	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744951	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744952	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744953	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744954	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744955	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1744956	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744957	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744958	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744959	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744960	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744961	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744962	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744963	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744964	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744965	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744966	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1744967	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1748441	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1748444	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1748450	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1748453	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1748455	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1748457	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1748458	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1749032	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749033	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749034	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749035	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749036	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749037	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749038	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749039	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749040	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749041	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749042	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749043	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749044	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749045	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749046	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749047	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749048	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749049	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749050	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749051	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749052	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749053	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749054	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749055	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749056	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749057	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749058	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749059	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749060	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749061	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749062	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749063	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749064	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749065	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749066	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749067	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749068	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749069	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749070	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749071	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749072	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749073	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749074	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749075	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749076	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749077	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749078	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749079	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749080	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749081	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749082	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749083	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749084	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749085	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749086	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749087	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749088	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749089	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749090	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749091	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749092	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1749093	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1749094	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1749095	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1749096	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749097	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	1749098	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	1749099	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1749100	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	1780_D	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	1-Jul	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538094	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538095	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538096	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538097	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538098	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538099	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538100	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538101	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538104	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538105	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538106	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538107	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538108	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2538109	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	2592457	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	28_T	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	3	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	415_B	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	431_D	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	435_D	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	455	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	45_T	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	477	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	4	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	514	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	522_D	TMPRSS2	chr21	42880008	ERG	chr21	39795483
COSMIC	54_T	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	560_D	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	5775	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	5776	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	5790	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	5794	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	580_B	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	5815	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	581_D	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	582	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	5864	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	5893	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	5912	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	60_T	TMPRSS2	chr21	42870046	ERG	chr21	39795483
COSMIC	66-01	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	69_T	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	712	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	78-01	TMPRSS2	chr21	42870046	ERG	chr21	39795483
COSMIC	79-01	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	791	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	7	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	83	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	88_T	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	Ambion 3	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	Clontech 1	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	Clontech 2	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	DuCaP	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	HGPIN 42	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	HGPIN 58	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	HGPIN 60	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	HGPIN 83	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	Jul-99	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	MET16	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	MET18	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	MET28-LN	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	MET3	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	NCI-H660	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	PC133	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PC295	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	PC310	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	PC324	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PC329	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	PC339	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PC82	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	PCa 101	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA10	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 114	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA11	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA12	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 138	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 139	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA13	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 140	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 145	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA14	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 152	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA15	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 164	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 172	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA1	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA2	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 32	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA3	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 40	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 45	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA4	TMPRSS2	chr21	42880008	ERG	chr21	39956869
COSMIC	PCA5	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 60	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 67	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA6	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA7	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 81	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 83	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCa 89	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA8	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCA9	TMPRSS2	chr21	42880008	ERG	chr21	39817544
COSMIC	PCEW	TMPRSS2	chr21	42866283	ERG	chr21	39817544
COSMIC	T1-1	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	T3-7	TMPRSS2	chr21	42870046	ERG	chr21	39817544
COSMIC	VCaP	TMPRSS2	chr21	42880008	ERG	chr21	39817544
CCLE	NCI-H660	TMPRSS2	chr21	42870046	ERG	chr21	39817544
CCLE	NCI-H660	TMPRSS2	chr21	42879877	ERG	chr21	39817544
CCLE	NCI-H660	TMPRSS2	chr21	42880008	ERG	chr21	39817544
CCLE	VCaP	TMPRSS2	chr21	42879877	ERG	chr21	39817544
CCLE	VCaP	TMPRSS2	chr21	42880008	ERG	chr21	39817544

Statistics of # Sampled Expressed This Fusion Gene Across Four Resources.

X-axis: resources, Y-axis: # samples

Fusion Gene and Drug/Small Molecule Search from PubMed Abstracts

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'].
*We used all combinations of gene synonyms of both partner genes and all combinations of ~ 14K drugs/small molecules in three categories of libraries (05-30-2024)

Statistics of the Found Drugs/Small Molecules.

PMID	Fusion Gene Name	Drug	Study Title
26793877	TMPRSS2-ERG	Abiraterone	[Current status of castration-resistant prostate cancer translational research].
24759320	TMPRSS2-ERG	Abiraterone	Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
28607007	TMPRSS2-ERG	Abiraterone	Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells.
38089454	TMPRSS2-ERG	Abiraterone	Identification of novel somatic fusions of ERG-VEGFA, TMPRSS2-ERG, and VEGFA-TMPRSS2 in prostate cancer treated with anlotinib and androgen deprivation therapy: A case report.
19339269	TMPRSS2-ERG	Abiraterone	Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.
25906745	TMPRSS2-ERG	Abiraterone	ERG deregulation induces IGF-1R expression in prostate cancer cells and affects sensitivity to anti-IGF-1R agents.
30807643	TMPRSS2-ERG	Abiraterone	The influence of treatment sequence in the prognostic value of TMPRSS2-ERG as biomarker of taxane resistance in castration-resistant prostate cancer.
28527407	TMPRSS2-ERG	Abiraterone	Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer.
33046892	TMPRSS2-ERG	Alectinib	Targetable gene fusions and aberrations in genitourinary oncology.
38089454	TMPRSS2-ERG	Anlotinib	Identification of novel somatic fusions of ERG-VEGFA, TMPRSS2-ERG, and VEGFA-TMPRSS2 in prostate cancer treated with anlotinib and androgen deprivation therapy: A case report.
36034583	TMPRSS2-ERG	Apalutamide	Oligometastatic Squamous Cell Transformation From Metastatic Prostate Adenocarcinoma Treated With Systemic and Focal Therapy: A Case Report.
28607007	TMPRSS2-ERG	Bicalutamide	Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells.
26948395	TMPRSS2-ERG	Cabazitaxel	TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer.
28527407	TMPRSS2-ERG	Cabazitaxel	Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer.
33046892	TMPRSS2-ERG	Crizotinib	Targetable gene fusions and aberrations in genitourinary oncology.
24504051	TMPRSS2-ERG	Cytarabine	ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells.
22313860	TMPRSS2-ERG	Cytarabine	Phase II study of cytarabine in men with docetaxel-refractory, castration-resistant prostate cancer with evaluation of TMPRSS2-ERG and SPINK1 as serum biomarkers.
24504051	TMPRSS2-ERG	Dasatinib	ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells.
23251544	TMPRSS2-ERG	Disulfiram	Chemical biology drug sensitivity screen identifies sunitinib as synergistic agent with disulfiram in prostate cancer cells.
28259472	TMPRSS2-ERG	Docetaxel	"Corrigendum re: ""TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer"" [Eur Urol 2016;70:709-13]."
27127882	TMPRSS2-ERG	Docetaxel	Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer.
26948395	TMPRSS2-ERG	Docetaxel	TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer.
30807643	TMPRSS2-ERG	Docetaxel	The influence of treatment sequence in the prognostic value of TMPRSS2-ERG as biomarker of taxane resistance in castration-resistant prostate cancer.
28842510	TMPRSS2-ERG	Docetaxel	Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy.
31614005	TMPRSS2-ERG	Docetaxel	Targeting the TMPRSS2/ERG fusion mRNA using liposomal nanovectors enhances docetaxel treatment in prostate cancer.
28527407	TMPRSS2-ERG	Docetaxel	Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer.
20124490	TMPRSS2-ERG	Dutasteride	Variability in the androgen response of prostate epithelium to 5alpha-reductase inhibition: implications for prostate cancer chemoprevention.
31763365	TMPRSS2-ERG	Entrectinib	Prostatic adenocarcinoma with novel NTRK3 gene fusion: a case report.
29712692	TMPRSS2-ERG	Enzalutamide	Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth.
26793877	TMPRSS2-ERG	Enzalutamide	[Current status of castration-resistant prostate cancer translational research].
24759320	TMPRSS2-ERG	Enzalutamide	Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
28607007	TMPRSS2-ERG	Enzalutamide	Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells.
31638934	TMPRSS2-ERG	Enzalutamide	TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model.
30807643	TMPRSS2-ERG	Enzalutamide	The influence of treatment sequence in the prognostic value of TMPRSS2-ERG as biomarker of taxane resistance in castration-resistant prostate cancer.
30718921	TMPRSS2-ERG	Enzalutamide	TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells.
28527407	TMPRSS2-ERG	Enzalutamide	Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer.
32313004	TMPRSS2-ERG	Enzalutamide	Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model.
33046892	TMPRSS2-ERG	Erdafitinib	Targetable gene fusions and aberrations in genitourinary oncology.
18798265	TMPRSS2-ERG	Flutamide	Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer.
21731703	TMPRSS2-ERG	Flutamide	Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expression.
27023109	TMPRSS2-ERG	Flutamide	Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide.
26571387	TMPRSS2-ERG	Imidazole	Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.
25088707	TMPRSS2-ERG	Imidazole	Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.
33046892	TMPRSS2-ERG	Infigratinib	Targetable gene fusions and aberrations in genitourinary oncology.
24759320	TMPRSS2-ERG	JQ1	Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
31763365	TMPRSS2-ERG	Larotrectinib	Prostatic adenocarcinoma with novel NTRK3 gene fusion: a case report.
33771697	TMPRSS2-ERG	Methionine	Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation-Mass Spectrometry Assays.
37894421	TMPRSS2-ERG	Naproxen	Differential Effect of Non-Steroidal Anti-Inflammatory Drugs Aspirin and Naproxen against TMPRSS2-ERG (Fusion)-Driven and Non-Fusion-Driven Prostate Cancer.
33301988	TMPRSS2-ERG	Nicotinamide	Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway.
24504051	TMPRSS2-ERG	Nilotinib	ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells.
30542657	TMPRSS2-ERG	Nilutamide	CRISPR-Induced TMPRSS2-ERG Gene Fusions in Mouse Prostate Organoids.
34527198	TMPRSS2-ERG	Olaparib	MicroRNA-regulated transcriptome analysis identifies four major subtypes with prognostic and therapeutic implications in prostate cancer.
33046892	TMPRSS2-ERG	Pemigatinib	Targetable gene fusions and aberrations in genitourinary oncology.
32123273	TMPRSS2-ERG	Ribose	Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.
34884926	TMPRSS2-ERG	Ribose	Genomic Features and Clinical Implications of Intraductal Carcinoma of the Prostate.
23565244	TMPRSS2-ERG	Rucaparib	PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells.
37847647	TMPRSS2-ERG	Serine	Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression.
27276682	TMPRSS2-ERG	Spermine	Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer.
27023109	TMPRSS2-ERG	Squalene	Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide.
25933120	TMPRSS2-ERG	Squalene	Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer.
29727181	TMPRSS2-ERG	Squalene	"New Formulation for the Delivery of Oligonucleotides Using ""Clickable"" siRNA-Polyisoprenoid-Conjugated Nanoparticles: Application to Cancers Harboring Fusion Oncogenes."
32123273	TMPRSS2-ERG	Temozolomide	Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.
24806330	TMPRSS2-ERG	Triptorelin	Evaluation of urinary prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG score changes when starting androgen-deprivation therapy with triptorelin 6-month formulation in patients with locally advanced and metastatic prostate cancer.

Statistics of # PMIDs per found drug for this fusion gene.

X-axis: drugs, Y-axis: # PMIDs

Fusion Gene and Diseases from the Found PubMed Abstracts

Diseases Related to This Fusion Gene from the Found PMID's MeSH terms

MeSH ID	MeSH Term
D064129	Prostatic Neoplasms, Castration-Resistant
D011471	Prostatic Neoplasms
D000230	Adenocarcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Kidney Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms
D002292	Adenocarcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Kidney Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms
D002295	Adenocarcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Kidney Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms
D007680	Adenocarcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Kidney Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms
D001749	Adenocarcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Kidney Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms
D014565	Adenocarcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Kidney Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms
D054218	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
D018572	Disease-Free Survival; Prostatic Neoplasms, Castration-Resistant
D001859	Bone Neoplasms; Prostatic Neoplasms, Castration-Resistant
D018278	Carcinoma, Neuroendocrine; Prostatic Neoplasms
D004195	Carcinoma, Neuroendocrine; Prostatic Neoplasms
D009369	Neoplasms

Fusion Gene and Diseases from Manual Curation and Other Resource

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
TMPRSS2	ERG	Prostate Cancer	PubMed	31614005
TMPRSS2	ERG	Prostate Adenocarcinoma	MyCancerGenome
TMPRSS2	ERG	Prostate Neuroendocrine Neoplasm	MyCancerGenome
TMPRSS2	ERG	Prostate Small Cell Carcinoma	MyCancerGenome
TMPRSS2	ERG	Bladder Urothelial Carcinoma	MyCancerGenome
TMPRSS2	ERG	Neuroendocrine Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TMPRSS2	C0033578	Prostatic Neoplasms	4	CTD_human
Hgene	TMPRSS2	C0376358	Malignant neoplasm of prostate	4	CTD_human
Tgene	ERG	C0033578	Prostatic Neoplasms	7	CTD_human
Tgene	ERG	C0376358	Malignant neoplasm of prostate	7	CTD_human

Details of the Found Drugs/Small Molecules

Details of the Found Drugs/Small Molecules from DrugBank.

DrugBank ID	Generic Name	Drug Type	Drug Group	Structure	Weight	Chemical Formula	Synonyms	SMILES
DB05812	Abiraterone	small molecule	approved		349.509	C24H31NO	"(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, Abiraterona, Abiraterone"	[H][C@@]12CC=C(C3=CC=CN=C3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
DB11363	Alectinib	small molecule	"approved, investigational"		482.6166	C30H34N4O2	"9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, Alectinib"	CCC1=CC2=C(C=C1N1CCC(CC1)N1CCOCC1)C(C)(C)C1=C(C3=CC=C(C=C3N1)C#N)C2=O
DB11901	Apalutamide	small molecule	"approved, investigational"		477.44	C21H15F4N5O2S	Apalutamide	CNC(=O)C1=CC=C(C=C1F)N1C(=S)N(C(=O)C11CCC1)C1=CC(=C(N=C1)C#N)C(F)(F)F
DB01128	Bicalutamide	small molecule	approved		430.373	C18H14F4N2O4S	"Bicalutamida, Bicalutamide, Bicalutamidum"	CC(O)(CS(=O)(=O)C1=CC=C(F)C=C1)C(=O)NC1=CC(=C(C=C1)C#N)C(F)(F)F
DB06772	Cabazitaxel	small molecule	approved		835.9324	C45H57NO14	"1-HYDROXY-7.BETA.,10.BETA.-DIMETHOXY-9-OXO-5.BETA.,20-EPOXYTAX-11-ENE-2.ALPHA.,4,13.ALPHA.-TRIYL 4-ACETATE 2-BENZOATE 13-((2R,3S)-3-(((TERT-BUTOXY)CARBONYL)AMINO)-2-HYDROXY-3-PHENYLPROPANOATE), Cabazitaxel, Cabazitaxelum"	[H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C4=CC=CC=C4)C(C)=C([C@@H](OC)C(=O)[C@]1(C)[C@H](C[C@H]1OC[C@@]21OC(C)=O)OC)C3(C)C
DB08865	Crizotinib	small molecule	"approved, investigational"		450.337	C21H22Cl2FN5O	"(R)-crizotinib, Crizotinib, Crizotinibum"	C[C@@H](OC1=CC(=CN=C1N)C1=CN(N=C1)C1CCNCC1)C1=C(Cl)C=CC(F)=C1Cl
DB00987	Cytarabine	small molecule	"approved, investigational"		243.2166	C9H13N3O5	"1-beta-D-Arabinofuranosylcytosine, 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone, Citarabina, Cytarabine, Cytarabine liposome, Cytarabinum, Cytosine arabinoside, Cytosine-1-beta-D-arabinofuranoside, cytosine-β-D-arabinofuranoside"	NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
DB01254	Dasatinib	small molecule	"approved, investigational"		488.006	C22H26ClN7O2S	"Anh. dasatinib, Anhydrous dasatinib, BMS dasatinib, Dasatinib, Dasatinib (anh.), dasatinib (anhydrous), Dasatinib anhydrous, Dasatinibum, N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-ca	CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1
DB00822	Disulfiram	small molecule	approved		296.539	C10H20N2S4	"1,1'-dithiobis(N,N-diethylthioformamide), bis(diethylthiocarbamoyl) disulfide, Disulfiram, N,N,N',N'-tetraethylthiuram disulfide, Tetraethylthioperoxydicarbonic diamide, Tetraethylthiuram disulfide, Tetraethylthiuram disulphide"	CCN(CC)C(=S)SSC(=S)N(CC)CC
DB01248	Docetaxel	small molecule	"approved, investigational"		807.8792	C43H53NO14	"Docetaxel, Docetaxel anhydrous, N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel, N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol, TXL"	[H][C@@]1(C[C@@]2(O)[C@@H](OC(=O)C3=CC=CC=C3)[C@]3([H])[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C(=C1C)C2(C)C)OC(C)=O)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C1=CC=CC=C1
DB01126	Dutasteride	small molecule	"approved, investigational"		528.5297	C27H30F6N2O2	"(5α,17β)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide, Dutasterida, Dutasteride, α,α,α,α',α',α'-hexafluoro-3-oxo-4-aza-5α-androst-1-ene-17β-carboxy-2',5'-xylidide"	[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])NC(=O)C=C[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)NC1=CC(=CC=C1C(F)(F)F)C(F)(F)F
DB11986	Entrectinib	small molecule	"approved, investigational"		560.65	C31H34F2N6O2	"Entrectinib, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide"	CN1CCN(CC1)C1=CC=C(C(=O)NC2=NNC3=CC=C(CC4=CC(F)=CC(F)=C4)C=C23)C(NC2CCOCC2)=C1
DB08899	Enzalutamide	small molecule	approved		464.436	C21H16F4N4O2S	"Enzalutamida, Enzalutamide"	CNC(=O)C1=C(F)C=C(C=C1)N1C(=S)N(C(=O)C1(C)C)C1=CC=C(C#N)C(=C1)C(F)(F)F
DB12147	Erdafitinib	small molecule	"approved, investigational"		446.555	C25H30N6O2	Erdafitinib	COC1=CC(=CC(OC)=C1)N(CCNC(C)C)C1=CC=C2N=CC(=NC2=C1)C1=CN(C)N=C1
DB00499	Flutamide	small molecule	"approved, investigational"		276.2118	C11H11F3N2O3	"4'-nitro-3'-trifluoromethylisobutyranilide, Flutamid, Flutamida, Flutamide, Flutamidum, FTA, NFBA, Niftolid, Niftolide, α,α,α-trifluoro-2-methyl-4'-nitro-m-propionotoluidide"	CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F
DB11886	Infigratinib	small molecule	"approved, investigational"		560.475	C26H31Cl2N7O3	Infigratinib	CCN1CCN(CC1)C1=CC=C(NC2=CC(=NC=N2)N(C)C(=O)NC2=C(Cl)C(OC)=CC(OC)=C2Cl)C=C1
DB14723	Larotrectinib	small molecule	"approved, investigational"		428.444	C21H22F2N6O2	Larotrectinib	O[C@H]1CCN(C1)C(=O)NC1=C2N=C(C=CN2N=C1)N1CCC[C@@H]1C1=C(F)C=CC(F)=C1
DB02893	D-Methionine	small molecule	"approved, experimental, investigational"		149.211	C5H11NO2S		CSCC[C@@H](N)C(O)=O
DB00788	Naproxen	small molecule	"approved, vet_approved"		230.2592	C14H14O3	"(+)-(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, (+)-(S)-Naproxen, (+)-2-(6-Methoxy-2-naphthyl)propionic acid, (+)-2-(Methoxy-2-naphthyl)-propionic acid, (+)-2-(Methoxy-2-naphthyl)-propionsäure, (+)-Naproxen, (S)-(+)-2-(6-Methoxy-2-naphthyl)propion	COC1=CC2=C(C=C1)C=C(C=C2)[C@H](C)C(O)=O
DB02701	Nicotinamide	small molecule	"approved, investigational"		122.1246	C6H6N2O	"3-pyridinecarboxamide, Niacinamide, Nicotinamida, Nicotinamide, Nicotinamidum, Nicotinic acid amide, Nicotinic amide, β-pyridinecarboxamide"	NC(=O)C1=CC=CN=C1
DB04868	Nilotinib	small molecule	"approved, investigational"		529.5158	C28H22F3N7O	"Nilotinib, Nilotinibum"	CC1=CN(C=N1)C1=CC(NC(=O)C2=CC=C(C)C(NC3=NC=CC(=N3)C3=CN=CC=C3)=C2)=CC(=C1)C(F)(F)F
DB00665	Nilutamide	small molecule	"approved, investigational"		317.2207	C12H10F3N3O4	"5,5-Dimethyl-3-(α,α,α-trifluoro-4-nitro-m-tolyl)hydantoin, Nilutamida, Nilutamide, Nilutamidum"	CC1(C)NC(=O)N(C1=O)C1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F
DB09074	Olaparib	small molecule	approved		434.4628	C24H23FN4O3	"4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, Olaparib"	FC1=CC=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1C(=O)N1CCN(CC1)C(=O)C1CC1
DB15102	Pemigatinib	small molecule	"approved, investigational"		487.508	C24H27F2N5O4	"INCB054828, Pemigatinib"	CCN1C(=O)N(CC2=CN=C3NC(CN4CCOCC4)=CC3=C12)C1=C(F)C(OC)=CC(OC)=C1F
DB12332	Rucaparib	small molecule	"approved, investigational"		323.371	C19H18FN3O	Rucaparib	CNCC1=CC=C(C=C1)C1=C2CCNC(=O)C3=C2C(N1)=CC(F)=C3
DB14096	"1,2-icosapentoyl-sn-glycero-3-phosphoserine"	small molecule	"approved, experimental"		842.064	C47H72NO10P		[H]C(N)(COP(O)(=O)OCC([H])(COC(=O)CCCC=C/CC=C/CC=C/CC=C/CC=C/CC)OC(=O)CCCCC=C/CC=C/CC=C/CC=C/CC=C/CC)C(O)=O
DB11460	Squalene	small molecule	"approved, vet_approved"		410.73	C30H50	"(all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene, (E,E,E,E)-Squalene, Spinacene, Squalene, Supraene"	CC(C)=CCCC(C)=CCCC(C)=CCCC=C(/C)CCC=C(/C)CCC=C(C)C
DB00853	Temozolomide	small molecule	"approved, investigational"		194.1508	C6H6N6O2	"(S)-perillyl alcohol temozolomide, 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide, 8-	CN1N=NC2=C(N=CN2C1=O)C(N)=O
DB06825	Triptorelin	small molecule	"approved, vet_approved"		1311.473	C64H82N18O13	"(6-D-Tryptophan)luteinizing hormone-releasing hormone, (D-Trp6)-GnRH, Luteinizing hormone-releasing factor (pig), 6-D-tryptophan, pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2	, Triptorelin, Triptorelina, Triptoreline, Triptorelinum"

ADME (absorption, distribution, metabolism, and excretion) Properties of the Found Drugs/Small Molecules Using the Qikprop of Schrödinger.

Molecule	# stars	# amines	# amidines	# acids	# amides	# rotors	# rtvFG	CNS	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	dip^2/V	ACxDN^.5/SA	glob	QPpolrz	QPlogPC16	QPlogPoct	QPlogPw	QPlogPo/w	QPlogS	CIQPlogS	QPlogHERG	QPPCaco	QPlogBB	QPPMDCK	QPlogKp	IP(eV)	EA(eV)	# metab	QPlogKhsa	Human Oral Absorption	Percent Human Oral Absorption	SAfluorine	SAamideO	PSA	# NandO	Rule Of Five	# ringatoms	# in 34	# in 56	# noncon	# nonHatm	Rule Of Three	Jm	Spermine
Abiraterone	0	0	0	0	0	1	0	0	349.515	2.768	611.158	337.911	77.366	195.88	0	1152.424	1	3.2	0.0066496	0.005236	0.8698012	41.195	11.127	16.804	7.445	4.881	-6.082	-5.566	-4.573	1829.099	-0.179	950.162	-2.159	9.338	0.302	6	1.107	3	100	0	0	35.409	2	0	23	0	23	13	26	1	0.002
Alectinib	1	1	0	0	0	2	0	1	482.624	10.09	805.781	513.34	122.803	169.638	0	1516.661	1	8.2	0.0671295	0.0101765	0.7922711	54.879	14.651	25.093	12.748	4.17	-7.264	-6.772	-6.428	169.145	-0.463	80.18	-5.056	8.763	0.83	2	0.999	1	91.241	0	0	80.344	6	0	29	0	29	10	36	1	0
Anlotinib	0	1	0	0	0	7	0	0	407.443	8.666	733.95	334.484	99.849	262.726	36.892	1288.911	3	4	0.0582607	0.0094396	0.7803939	43.443	13.297	21.526	10.754	4.505	-5.572	-5.566	-7.065	279.213	-0.462	219.505	-3.825	8.586	0.83	4	0.847	3	100	36.892	0	72.21	6	0	22	3	19	3	30	0	0
Apalutamide	4	0	0	0	0	2	0	-2	477.435	13.675	744.822	220.433	180.706	142.77	200.914	1321.851	1	8	0.1414654	0.0107408	0.7820491	46.826	12.565	24.308	12.686	3.882	-8.365	-7.406	-5.74	191.542	-1.034	1045.122	-4.155	9.375	1.785	2	0.512	1	90.526	145.334	0	113.68	7	0	20	4	16	4	33	1	0
Bicalutamide	0	0	0	0	0	7	0	-2	430.373	7.547	611.897	143.347	177.024	159.33	132.196	1133.129	1	7.75	0.0502628	0.0126655	0.8590256	36.221	10.524	18.962	11.08	2.641	-5.056	-6.573	-4.573	207.576	-1.133	479.146	-3.549	9.815	1.394	2	-0.098	3	83.882	131.694	0	106.521	6	0	12	0	12	0	29	0	0.001
Cabazitaxel	7	0	0	0	0	13	3	-2	835.944	10.472	1059.311	612	175.607	271.704	0	2265.262	2	17.35	0.0484082	0.0231628	0.7874456	78.749	22.313	40.003	22.462	5.155	-6.602	-9.563	-6.267	214.1	-2.108	93.503	-2.551	9.872	0.435	7	0.636	1	59.966	0	0	199.86	15	3	29	4	22	13	60	2	0.001
Crizotinib	1	1	0	0	0	4	0	0	450.342	1.836	705.819	276.242	115.308	196.547	117.722	1279.647	3	5.25	0.002635	0.0128833	0.8076044	44.366	13.291	22.352	12.263	4.113	-5.569	-6.085	-6.309	199.22	-0.169	422.446	-4.631	7.898	0.573	5	0.763	3	92.18	40.557	0	73.496	6	0	23	0	23	5	30	0	0
Cytarabine	0	0	0	0	0	5	0	-2	243.219	9.29	447.001	117.695	262.735	66.571	0	738.312	5	10.8	0.1168946	0.0540257	0.8837919	20.818	8.542	21.598	19.893	-1.987	-1.611	-1.035	-3.73	31.944	-1.98	11.961	-5.647	9.073	0.012	4	-0.92	2	42.236	0	0	140.492	8	0	11	0	11	4	17	0	0.013
Dasatinib	0	1	0	0	0	7	0	-1	488.006	2.557	834.038	388.665	128.085	221.544	95.744	1474.925	3	10.7	0.0044341	0.0222208	0.751322	50.494	16.079	27.143	17.527	3.004	-5.494	-4.859	-7.339	150.721	-0.738	236.82	-4.49	8.657	1.396	6	0.15	3	83.519	0	0	105.843	9	0	23	0	23	4	33	0	0
Disulfiram	4	0	0	0	0	7	1	1	296.521	0.348	575.589	435.987	16.855	0	122.747	987.617	0	4	0.0001227	0	0.8332551	28.876	8.321	10.991	3.658	4.142	-4.426	-3.515	-4.23	6855.868	0.281	10000	-1.158	8.571	2.925	0	0.118	3	100	0	0	25.188	2	0	0	0	0	0	16	0	0.773
Docetaxel	7	0	0	0	0	13	3	-2	807.89	4.675	1031.915	496.508	220.255	315.153	0	2179.541	4	17.35	0.0100289	0.0336268	0.7878273	75.734	22.7	41.572	25.925	4.202	-6.326	-8.889	-6.468	80.765	-2.586	32.598	-3.22	9.525	0.515	8	0.472	1	59.766	0	0	223.683	15	2	29	4	22	13	58	2	0
Dutasteride	2	0	0	0	0	2	0	0	528.537	5.041	760.584	305.016	103.06	145.29	207.218	1439.24	2	5	0.0176576	0.0092969	0.8105375	51.548	12.442	23.924	10.725	6.31	-8.716	-8.431	-5.291	1043.719	-0.094	7072.573	-2.715	9.515	1.274	2	1.407	1	92	207.218	0	70.598	4	2	23	0	23	13	37	1	0
Entrectinib	1	1	0	0	0	6	0	1	560.645	4.959	918.941	435.368	108.96	280.83	93.783	1702.611	2	8.2	0.0144407	0.0126195	0.7503916	60.814	16.99	28.185	14.298	5.775	-8.008	-7.618	-7.636	228.841	-0.46	362.83	-4.025	8.177	0.525	5	1.29	1	77.074	93.783	0	93.206	8	2	33	0	33	9	41	1	0
Enzalutamide	2	0	0	0	0	2	0	-1	464.437	10.472	733.929	210.118	159.091	165.758	198.963	1310.803	1	7	0.0836532	0.0095377	0.7892284	46.603	12.446	22.848	11.683	4.413	-8.553	-7.807	-5.733	307.073	-0.772	1698.39	-3.676	9.283	1.597	1	0.695	1	100	144.062	0	100.859	6	0	17	0	17	1	32	1	0
Erdafitinib	0	1	0	0	0	8	0	1	446.551	3.358	829.528	488.845	68.206	272.477	0	1481.735	1	7	0.0076091	0.0084385	0.7577295	50.61	14.901	21.636	10.628	4.947	-6.192	-5.699	-7.478	557.192	-0.312	290.865	-3.111	8.13	1.117	6	0.889	3	100	0	0	73.878	8	0	21	0	21	0	33	1	0
Flutamide	0	0	0	0	0	3	0	0	276.215	11.638	501.942	176.963	117.145	105.454	102.38	825.009	1	3.5	0.1641777	0.0069729	0.8475215	25.944	6.885	14.114	6.727	3.349	-4.15	-3.78	-4.502	767.392	-0.453	1351.776	-3.019	9.946	1.581	3	0.067	3	100	102.38	0	76.982	5	0	6	0	6	0	19	0	0.019
Imidazole	8	0	0	0	0	0	0	1	68.078	5.009	227.436	0	64.991	162.445	0	308.088	1	2	0.0814317	0.0087937	0.9699643	7.727	3.067	5.465	5.248	-0.08	-0.483	-0.406	-2.793	2396.556	0.103	1272.446	-2.145	9.398	-0.773	0	-0.826	3	86.967	0	0	28.276	2	0	5	0	5	0	5	0	537.815
Infigratinib	0	1	0	0	1	7	0	1	560.482	7.955	862.864	507.238	89.929	202.159	63.537	1620.462	2	9	0.0390505	0.0147508	0.7732419	56.133	16.391	27.011	15.775	4.243	-5.676	-6.437	-5.517	226.474	-0.307	388.229	-3.855	8.332	0.54	6	0.566	3	80.979	0	23.239	91.99	10	1	24	0	24	4	38	0	0
JQ1	1	0	0	0	0	3	1	0	456.989	9.683	773.733	452.114	88.406	134.623	98.59	1405.133	0	5	0.0667321	0	0.7841256	49.439	13.652	20.148	7.396	5.949	-8.203	-7.353	-5.667	1437.293	-0.334	2539.292	-2.387	9.454	1.626	6	1.232	1	100	0	0	78.446	6	1	19	0	16	1	31	1	0
Larotrectinib	1	0	0	0	1	2	0	0	428.441	3.951	704.941	296.811	106.313	221.222	80.595	1265.401	2	6.2	0.0123374	0.0124381	0.8025972	45.316	12.248	21.728	13.356	3.688	-6.308	-5.725	-4.407	742.268	-0.46	1326.136	-2.508	7.694	0.647	4	0.396	1	100	80.595	14.72	88.035	8	0	25	0	25	8	31	1	0.001
Methionine	1	1	0	1	0	5	0	-1	149.207	2.374	360.332	170.778	146.423	0	43.131	553.401	3	3.5	0.0101802	0.0168239	0.9046666	12.783	5.32	10.033	8.336	-1.583	-0.655	0.051	-1.993	25.578	-0.426	22.805	-5.801	8.933	-0.256	3	-0.91	2	42.874	0	0	73.103	3	0	0	0	0	0	9	0	0.073
Naproxen	0	0	0	1	0	3	0	-1	230.263	2.528	471.155	180.422	92.871	197.861	0	788.121	1	2.75	0.008112	0.0058367	0.8757838	25.35	7.814	10.956	6.342	3.18	-4.156	-3.374	-2.678	330.217	-0.425	189.962	-2.246	8.546	0.702	2	-0.05	3	90.647	0	0	56.304	3	0	10	0	10	0	17	0	0.521
Nicotinamide	2	0	0	0	0	1	0	-1	122.126	6.802	305.217	0	139.794	165.422	0	456.272	2	4	0.1014174	0.0185339	0.9390872	13.044	5.199	10.41	9.178	-0.313	-0.4	-0.895	-3.307	467.983	-0.554	217.725	-3.417	10.075	0.62	3	-0.736	2	72.907	0	0	66.093	3	0	6	0	6	0	9	0	7.522
Nilotinib	3	0	0	0	0	5	0	-1	529.523	10.034	871.567	177.035	115.945	461.134	117.454	1567.448	2	8	0.0642283	0.0129809	0.748732	57.769	16.92	28.115	15.489	5.787	-8.737	-8.458	-7.797	787.761	-0.828	1681.81	-1.552	8.724	1.034	8	1.009	1	86.752	117.454	0	94.093	8	2	29	0	29	0	39	2	0
Nilutamide	2	0	0	0	0	1	0	-1	317.224	11.79	514.484	150.249	177.428	83.825	102.981	870.691	1	4.5	0.1596355	0.0087466	0.8571081	28.849	7.664	15.979	8.447	2.135	-4.369	-4.459	-4.244	205.753	-0.854	328.315	-4.398	10.511	1.707	2	0.094	3	80.852	102.981	0	109.341	7	0	11	0	11	1	22	0	0.001
Olaparib	0	0	0	0	1	4	1	-1	434.469	9.279	693.521	267.43	131.804	256.608	37.68	1298.333	1	8	0.066316	0.0115353	0.8299074	45.687	12.987	22.148	14.304	2.988	-4.631	-5.059	-4.134	356.927	-0.861	422.886	-2.661	9.375	1.132	1	0.071	3	90.125	37.68	24.3	109.126	7	0	25	3	22	7	32	0	0.022
Pemigatinib	0	1	0	0	0	5	0	1	487.505	3.974	745.867	515.203	73.219	96.984	60.46	1394.216	1	8.2	0.0113295	0.0109939	0.8092024	47.358	12.215	21.564	11.132	3.896	-4.985	-5.956	-5.808	499.415	0.064	553.988	-4.11	8.333	0.54	7	0.552	3	100	60.46	0	84.768	9	0	25	0	25	5	35	1	0
Ribose	2	0	0	0	0	8	0	-2	150.131	1.842	330.588	117.084	213.504	0	0	522.638	3	7.8	0.0064904	0.0408665	0.9491722	9.625	5.626	11.298	12.279	-1.658	0.024	-0.234	-2.354	93.593	-1.499	38.228	-4.686	10.624	-0.394	4	-1.072	2	52.517	0	0	117.936	5	0	0	0	0	0	10	0	3.27
Rucaparib	0	1	0	0	0	2	0	0	323.369	9.363	601.053	214.232	112.931	227.469	46.421	1031.944	3	4	0.0849593	0.0115268	0.8216555	36.033	10.531	19.625	11.39	2.826	-4.117	-3.714	-6.229	209.834	-0.16	181.782	-4.67	8.52	0.845	3	0.404	3	85.049	46.421	0	68.748	4	0	19	0	15	2	24	0	0.001
Serine	7	1	0	1	0	4	0	-1	105.093	4.096	272.981	71.159	201.822	0	0	392.425	3	3.7	0.0427617	0.0234763	0.9495917	6.982	4.089	8.738	8.905	-3.314	0.309	0.581	-1.266	7.63	-0.771	3.58	-6.918	9.99	-1.096	4	-1.1	1	23.336	0	0	96.827	4	0	0	0	0	0	7	1	0.052
Spermine	2	4	0	0	0	13	0	-1	202.342	2.27	558.466	410.974	147.492	0	0	901.909	6	5	0.0057142	0.0219305	0.8083697	21.593	8.805	17.52	12.911	-1.211	2	2.893	-7.537	6.137	-0.928	2.723	-7.115	9.314	-2.292	6	-0.811	2	20.997	0	0	83.682	4	1	0	0	0	0	14	1	1.553
Squalene	12	0	0	0	0	15	0	2	410.725	0.441	793.663	758.444	0	35.218	0	1593.55	0	0	0.0001219	0	0.8313288	48.325	13.086	14.962	-5.223	10.878	-14.402	-14.402	-4.429	9906.038	1.711	5899.293	0.045	9.26	-0.956	18	2.607	1	100	0	0	0	0	1	0	0	0	0	30	2	0
Temozolomide	1	0	0	0	0	1	0	-2	194.152	3.411	379.129	87.887	235.051	56.19	0	597.216	2	7	0.0194771	0.0261112	0.9046201	17.641	6.286	12.749	12.216	-1.22	-1.381	-1.328	-3.343	58.466	-1.412	22.989	-5.558	9.649	1.801	1	-0.8	2	51.425	0	0	130.572	8	0	9	0	9	0	14	0	0.022
Triptorelin	18	0	1	0	11	36	0	-2	1311.465	34.214	1703.368	717.019	565.523	420.825	0	3613.374	12.25	26.7	0.3239544	0.0548619	0.6685469	119.357	42.416	79.068	60.134	-1.677	-3.268	-8.599	6.216	0.002	-10.042	0.009	-9.066	7.667	0.317	20	-2.986	1	0	0	179.817	535.452	31	3	39	0	39	7	95	2	0

Clinical Trials of the Found Drugs/Small Molecules

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene Other terms in clinicaltrials.gov	Samll molecule Intervention in clinicaltrials.gov	NCT ID	Study Status	Phases	Disease	# Enrolment	Date
TMPRSS2-ERG	Dutasteride	NCT01653925	Active, not recruiting	Not Applicable	Prostatic Neoplasms	120	December 2024
TMPRSS2-ERG	Abiraterone	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Acetate	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Androstanedione	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Cabazitaxel	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Docetaxel	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Prednisone	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Sunitinib	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Triptorelin	NCT01020448	Completed	Phase 3	Prostate Cancer	339	June 2013
TMPRSS2-ERG	Goserelin	NCT02588404	Not yet recruiting		Prostate Cancer	65
TMPRSS2-ERG	Triptorelin	NCT02588404	Not yet recruiting		Prostate Cancer	65
TMPRSS2-ERG	Abiraterone	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Acetate	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Apalutamide	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Cabazitaxel	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Docetaxel	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Enzalutamide	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Prednisone	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Ribose	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Serine	NCT04854343	Recruiting		Prostate Cancer	280	July 1, 2024
TMPRSS2-ERG	Acetate	NCT01933022	Terminated	Phase 4	Metastatic Prostate Cancer	1	August 2015
TMPRSS2-ERG	Abiraterone	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Acetate	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Cabazitaxel	NCT02362620	Unknown status		Advanced Prostate Cancer	402	December 2020
TMPRSS2-ERG	Docetaxel	NCT02362620	Unknown status		Advanced Prostate Cancer	402	December 2020
TMPRSS2-ERG	Prednisone	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Dutasteride	NCT01653925	Active, not recruiting	Not Applicable	Prostatic Neoplasms	120	December 2024
TMPRSS2-ERG	Abiraterone	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Acetate	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Androstanedione	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Cabazitaxel	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Docetaxel	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Prednisone	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Sunitinib	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Triptorelin	NCT01020448	Completed	Phase 3	Prostate Cancer	339	June 2013
TMPRSS2-ERG	Goserelin	NCT02588404	Not yet recruiting		Prostate Cancer	65
TMPRSS2-ERG	Triptorelin	NCT02588404	Not yet recruiting		Prostate Cancer	65
TMPRSS2-ERG	Abiraterone	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Acetate	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Apalutamide	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Cabazitaxel	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Docetaxel	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Enzalutamide	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Prednisone	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Ribose	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Serine	NCT04854343	Recruiting		Prostate Cancer	280	July 1, 2024
TMPRSS2-ERG	Acetate	NCT01933022	Terminated	Phase 4	Metastatic Prostate Cancer	1	August 2015
TMPRSS2-ERG	Abiraterone	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Acetate	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Cabazitaxel	NCT02362620	Unknown status		Advanced Prostate Cancer	402	December 2020
TMPRSS2-ERG	Docetaxel	NCT02362620	Unknown status		Advanced Prostate Cancer	402	December 2020
TMPRSS2-ERG	Prednisone	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Dutasteride	NCT01653925	Active, not recruiting	Not Applicable	Prostatic Neoplasms	120	December 2024
TMPRSS2-ERG	Abiraterone	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Acetate	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Androstanedione	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Cabazitaxel	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Docetaxel	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Prednisone	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Sunitinib	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Triptorelin	NCT01020448	Completed	Phase 3	Prostate Cancer	339	June 2013
TMPRSS2-ERG	Goserelin	NCT02588404	Not yet recruiting		Prostate Cancer	65
TMPRSS2-ERG	Triptorelin	NCT02588404	Not yet recruiting		Prostate Cancer	65
TMPRSS2-ERG	Abiraterone	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Acetate	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Apalutamide	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Cabazitaxel	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Docetaxel	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Enzalutamide	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Prednisone	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Ribose	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Serine	NCT04854343	Recruiting		Prostate Cancer	280	July 1, 2024
TMPRSS2-ERG	Acetate	NCT01933022	Terminated	Phase 4	Metastatic Prostate Cancer	1	August 2015
TMPRSS2-ERG	Abiraterone	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Acetate	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Cabazitaxel	NCT02362620	Unknown status		Advanced Prostate Cancer	402	December 2020
TMPRSS2-ERG	Docetaxel	NCT02362620	Unknown status		Advanced Prostate Cancer	402	December 2020
TMPRSS2-ERG	Prednisone	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Dutasteride	NCT01653925	Active, not recruiting	Not Applicable	Prostatic Neoplasms	120	December 2024
TMPRSS2-ERG	Abiraterone	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Acetate	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Androstanedione	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Cabazitaxel	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Docetaxel	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Prednisone	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Sunitinib	NCT01858441	Completed	Not Applicable	Pharmacogenetic Study	148	December 3, 2020
TMPRSS2-ERG	Triptorelin	NCT01020448	Completed	Phase 3	Prostate Cancer	339	June 2013
TMPRSS2-ERG	Goserelin	NCT02588404	Not yet recruiting		Prostate Cancer	65
TMPRSS2-ERG	Triptorelin	NCT02588404	Not yet recruiting		Prostate Cancer	65
TMPRSS2-ERG	Abiraterone	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Acetate	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Apalutamide	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Cabazitaxel	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Docetaxel	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Enzalutamide	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Prednisone	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Ribose	NCT03903835	Recruiting	Phase 3	Metastatic Castration-resistant Prostate Cancer (mCRPC)	750	December 2026
TMPRSS2-ERG	Serine	NCT04854343	Recruiting		Prostate Cancer	280	July 1, 2024
TMPRSS2-ERG	Acetate	NCT01933022	Terminated	Phase 4	Metastatic Prostate Cancer	1	August 2015
TMPRSS2-ERG	Abiraterone	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Acetate	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020
TMPRSS2-ERG	Cabazitaxel	NCT02362620	Unknown status		Advanced Prostate Cancer	402	December 2020
TMPRSS2-ERG	Docetaxel	NCT02362620	Unknown status		Advanced Prostate Cancer	402	December 2020
TMPRSS2-ERG	Prednisone	NCT02787837	Unknown status		Advanced Prostate Cancer	220	December 2020

Fusion-Positive Patients' Treatment Records

Fusion-Positive Patients' Treatment Records in TCGA cohorts

Fusion Gene	Drugs
TMPRSS2-ERG	Casodex, Docetaxel, Eligard, Goserelin, Leuprolide Acetate, Leuprorelin, Lupron

Generative AI Summary Sentence of the Relationship Between Fusion Gene and Small Molecule that Have at Least Thrree PMIDs from PubMed

Generative AI summary sentence of the relationship between fusion gene and small molecule that have at least thrree PMIDs from PubMed using the ChatGPT 4

Found PMIDs	Fusion Gene	Drugs	Once Sentence Summary
# pmid >4	TMPRSS2-ERG	Abiraterone	TMPRSS2-ERG and Abiraterone: Abiraterone, an androgen synthesis inhibitor, has shown efficacy in treating prostate cancers, including those with TMPRSS2-ERG fusion, although the fusion status may not directly predict response.
# pmid >1	TMPRSS2-ERG	Apalutamide	TMPRSS2-ERG and Apalutamide: Apalutamide inhibits the growth of TMPRSS2-ERG positive prostate cancer cells.
# pmid >4	TMPRSS2-ERG	Bicalutamide	TMPRSS2-ERG and Bicalutamide: Bicalutamide, an antiandrogen used in prostate cancer treatment, may have differing efficacy in TMPRSS2-ERG fusion-positive tumors, though the relationship is not fully elucidated.
# pmid >4	TMPRSS2-ERG	Docetaxel	TMPRSS2-ERG and Docetaxel: Docetaxel is a chemotherapy agent used in the treatment of advanced prostate cancer, including cases with TMPRSS2-ERG fusion, although the fusion status may not directly influence response.
# pmid >4	TMPRSS2-ERG	Enzalutamide	TMPRSS2-ERG and Enzalutamide: Enzalutamide, an androgen receptor inhibitor, has demonstrated effectiveness in treating prostate cancers, including those with TMPRSS2-ERG fusion, though the fusion status alone may not determine response.
# pmid >1	TMPRSS2-ERG	Finasteride	TMPRSS2-ERG and Finasteride: Finasteride reduces the risk of prostate cancer, including cancers involving TMPRSS2-ERG fusions, by lowering androgen levels.
# pmid >1	TMPRSS2-ERG	Goserelin	TMPRSS2-ERG and Goserelin: Goserelin, a GnRH agonist, does not directly affect TMPRSS2-ERG but is used in androgen deprivation therapy for prostate cancer, which often harbors TMPRSS2-ERG fusions.
# pmid >1	TMPRSS2-ERG	Imidazole	TMPRSS2-ERG and Imidazole: Imidazole derivatives have been explored for their inhibitory effects on the TMPRSS2-ERG fusion protein in prostate cancer, potentially affecting cell proliferation and survival .
# pmid >1	TMPRSS2-ERG	Lycopene	TMPRSS2-ERG and Lycopene: Lycopene intake may lower the risk of prostate cancer in TMPRSS2:ERG-positive cases .
# pmid >4	TMPRSS2-ERG	Ribose	TMPRSS2-ERG and Ribose: There is limited published research specifically addressing the relationship between TMPRSS2-ERG fusion and ribose in prostate cancer.
# pmid >4	TMPRSS2-ERG	Serine	TMPRSS2-ERG and Serine: Some studies have suggested that TMPRSS2-ERG fusion-positive prostate cancers may have altered serine metabolism, potentially offering new therapeutic targets, though more research is needed to fully elucidate this relationship.
# pmid >4	TMPRSS2-ERG	Trypsin	TMPRSS2-ERG and Trypsin: TMPRSS2-ERG fusion in prostate cancer may affect the expression of trypsin-like serine proteases, potentially influencing tumor progression and metastasis.