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About TranslFac

To have a better understanding of the conservative or condition-specific translation systems and to fill the gap of lack of knowledge on the translation process in humans, systematic analytic studies of human translation factors are essential. TranslFac, a knowledgebase of human translation factors in cancer, provides multiple genomic/ epigenomic/ phenotypic landscapes and aberrations in cancer of individual 617 human translation factors obtained from the translation process of Gene Ontology (GO:0006412). TranslFac is the unique resource for the systematic annotations of human translation factors. We will continue to update TranslFac by integrating suitable ribosome binding data appeared in the future.

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Examples: Gene symbol: EIF5A1, Entrez gene ID: 1984
bullet pointBrowse by child GO term of GO:0006412 (translation).
GO:0006412 (translation, itself, 607)
- GO:0006417 (regulation of translation, child term, 403)
- GO:0005840 (ribosome, child term, 160)
- GO:0017148 (negative regulation of translation, child term, 150)
- GO:0045727 (positive regulation of translation, child term, 137)
- GO:0002181 (cytoplasmic translation, child term, 136)
- GO:0006413 (translational initiation, child term, 121)
- GO:0008135 (translation factor activity, RNA binding, child term, 85)
- GO:0032543 (mitochondrial translation, child term, 72)
- GO:0006414 (translational elongation, child term, 56)
- GO:0006418 (tRNA aminoacylation for protein translation, child term, 45)
- GO:0006415 (translational termination, child term, 18)
- GO:1990145 (maintenance of translational fidelity, child term, 2)
- GO:0006614 (SRP-dependent cotranslational protein targeting to membrane, child term, 1)
- GO:0043143 (regulation of translation by machinery localization, child term, 1)
bullet pointBrowse by important cellular gene groups.
Kinases (26)  Transcription factors (18) 
Cancer Gene Census (31)  Tumor suppressors (32) 
IUPHAR drug targets (48)  Cell metabolism genes (173) 
Human essential genes (471)  Epigenetic factors (20)