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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: FARSB (NCBI Gene ID:10056)

Gene Summary

Gene Summary

Gene Information	Gene Name: FARSB
	Gene ID: 10056
	Gene Symbol	FARSB
	Gene ID	10056
	Gene Name	phenylalanyl-tRNA synthetase subunit beta
	Synonyms	FARSLB\|FRSB\|HSPC173\|NEDBLLA\|PheHB\|PheRS\|RILDBC
	Cytomap	2q36.1
	Type of Gene	protein-coding
	Description	phenylalanine--tRNA ligase beta subunitphenylalanine tRNA ligase 1, beta, cytoplasmicphenylalanine-tRNA ligase beta chainphenylalanine-tRNA synthetase-like, beta subunitphenylalanyl-tRNA synthetase beta chainphenylalanyl-tRNA synthetase beta subunit
	Modification date	20200313
	UniProtAcc	Q9NSD9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006418	tRNA aminoacylation for protein translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FARSB	GO:0006432	phenylalanyl-tRNA aminoacylation	20223217
Hgene	FARSB	GO:0051290	protein heterotetramerization	20223217

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
FARSB	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'FARSB[title] AND translation [title] AND human.'

Gene	Title	PMID
FARSB	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000281828	223464646	223464802	In-frame
ENST00000281828	223484363	223484456	In-frame
ENST00000281828	223489432	223489494	Frame-shift
ENST00000281828	223493555	223493607	Frame-shift
ENST00000281828	223505580	223505650	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000281828	223464646	223464802	3386	1727	1882	589	487	539
ENST00000281828	223484363	223484456	3386	1516	1608	589	417	448

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9NSD9	487	539	1	589	Chain	ID=PRO_0000127016;Note=Phenylalanine--tRNA ligase beta subunit
Q9NSD9	417	448	1	589	Chain	ID=PRO_0000127016;Note=Phenylalanine--tRNA ligase beta subunit
Q9NSD9	417	448	416	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	417	448	420	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	417	448	425	427	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	417	448	438	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	417	448	445	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	417	448	448	450	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	487	539	490	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	487	539	508	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	487	539	528	531	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G
Q9NSD9	487	539	532	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L4G

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
READ	FARSB	2.65071268625374	0.03125
LUAD	FARSB	-2.83348648273324	1.1231169993161e-10
LIHC	FARSB	-1.7132964750044	1.20023265700096e-06
PRAD	FARSB	-2.64671953148481	5.39258049843884e-06
COAD	FARSB	2.04245453812798	7.02440738677979e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
THCA	FARSB	0.215364165	0.007284457
THYM	FARSB	0.102217282	0.027411017

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with FARSB (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	FARSB	NOP56	0.82937803	3.28E-13
KICH	Cell metabolism gene	FARSB	ATIC	0.808092294	3.63E-22
KICH	CGC	FARSB	ATIC	0.808092294	3.63E-22
LAML	Cell metabolism gene	FARSB	PAICS	0.807838372	4.14E-41
TGCT	Cell metabolism gene	FARSB	SRM	0.807146921	4.47E-37
TGCT	Cell metabolism gene	FARSB	POLR1C	0.808151092	3.11E-37
THYM	Cell metabolism gene	FARSB	TOMM40	0.804065776	7.18E-29
THYM	Cell metabolism gene	FARSB	ATIC	0.805238172	5.20E-29
THYM	Cell metabolism gene	FARSB	GEMIN6	0.828712712	4.94E-32
THYM	Cell metabolism gene	FARSB	NME1	0.831705688	1.89E-32
THYM	CGC	FARSB	ATIC	0.805238172	5.20E-29
THYM	TSG	FARSB	NME1	0.831705688	1.89E-32
UCS	Cell metabolism gene	FARSB	TOMM40	0.804065776	7.18E-29
UCS	Cell metabolism gene	FARSB	ATIC	0.805238172	5.20E-29
UCS	Cell metabolism gene	FARSB	GEMIN6	0.828712712	4.94E-32
UCS	Cell metabolism gene	FARSB	NME1	0.831705688	1.89E-32
UCS	CGC	FARSB	ATIC	0.805238172	5.20E-29
UCS	TSG	FARSB	NME1	0.831705688	1.89E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	FARSB	KARS	-2.30407630249645	0.00019507110118866
STAD	FARSB	YARS	-6.49411565641968	0.000280400272458792
HNSC	FARSB	YARS	1.29642872422682	0.000481783007217019
STAD	FARSB	AARS	-1.37044043826934	0.000657554250210524
BRCA	FARSB	ABCE1	1.3740626146648	0.000669229587514616
STAD	FARSB	EPRS	-1.48171581324647	0.000789262883452143
HNSC	FARSB	FARSA	1.39503753390765	0.00243284819134715
THCA	FARSB	WARS	2.95768973159174	0.00305071956645465
LIHC	FARSB	ABCE1	1.33775121002715	0.0033398145023608
ESCA	FARSB	FARSA	-2.46915074720865	0.0048828125
KIRC	FARSB	WARS	-3.93324665771133	0.00591357067334741
BLCA	FARSB	KARS	-1.18480170691913	0.0061798095703125
STAD	FARSB	TARS	-3.24156946700831	0.0105091729201376
CHOL	FARSB	IARS	-2.92341608141499	0.01171875
LIHC	FARSB	FARSA	-1.43180546789634	0.0124123499319886
HNSC	FARSB	ABCE1	1.20332081233659	0.0124875666290336
BLCA	FARSB	ABCE1	-4.08863120087471	0.0229873657226562
READ	FARSB	WARS	-1.7125292902591	0.03125
KIRP	FARSB	FARSA	-1.07764350983063	0.0324882394634187
STAD	FARSB	FARS2	-2.90593264356265	0.0475412011146545
PRAD	FARSB	ABCE1	-2.9089513514626	1.31460603050763e-05
THCA	FARSB	YARS	-1.52851760350795	1.38467683131598e-09
LIHC	FARSB	EPRS	-7.10731017811505	2.28054594243154e-08
KICH	FARSB	YARS	-2.00632816869948	2.98023223876953e-07
LIHC	FARSB	IARS	-1.16847098939898	3.43009058766818e-06
LUSC	FARSB	FARSA	-8.32225794284562	3.6218774072117e-09
BRCA	FARSB	YARS	-2.58863291399932	3.63754942015711e-21
LUSC	FARSB	WARS	-1.79063789640973	4.0549719008113e-07
LUAD	FARSB	WARS	-1.3247218686619	4.20890892730867e-05
LUAD	FARSB	AARS	-6.1139400689607	4.40386642176516e-08
THCA	FARSB	FARS2	-2.37455669017165	4.94122257479853e-08
BRCA	FARSB	FARSA	-1.67900690303803	5.56833473175494e-18
KIRC	FARSB	TARS	-1.12274315049792	5.64962994208288e-07
STAD	FARSB	FARSA	-4.23623156710319	8.09784978628159e-07
PRAD	FARSB	EPRS	-1.76339127457265	9.52775218277559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with FARSB

DDA1, UBA5, CD4, EIF2AK2, HDGF, FARSA, IARS, USP8, AARS, VCAM1, FN1, ITGA4, FAF1, GANAB, PLOD2, UGP2, XRCC6, GART, HSPH1, PAICS, RANBP3, RPL24, RPLP0, RPLP1, SET, SF1, SUPT5H, SWAP70, NXF1, DTX3, TEKT2, TARS, TARSL2, OGT, NTRK1, GLI1, FOXR1, MCM2, OTUB1, GTF2E2, APBA3, GPX7, FGB, MAGEB10, USP47, UBE2A, CTNNBL1, FARSB, INTS5, LEO1, HSPA8, MTCH2, EFTUD2, AAR2, ARIH1, ESR2, HEXIM1, WWOX, RECQL4, MYC, EZR, ATG16L1, ACTC1, PHB, TPT1, NR2C2, MAB21L2, MTMR14, ITFG1, GSK3B, BIRC3, LMBR1L, TRIM28, PLEKHA4, KCTD10, PINK1, ENG, PTEN, ZC3H18, FGFR1, PTPRR, RAC1, SH2D3C, ANKRD55, ESR1, ANLN, MAD2L2, SUMO2, BRD4, LGALS9, NR3C1, MSRA, CD274, SKA3, FZR1, NAA40, GHRL, AMD1, SCYL3, ARSF, CENPM, MTPN, ZBTB9, BRK1, PITX1, HSBP1, SPRTN, ZRANB1, SF3B4, TOLLIP,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
FARSB	chr2	223436607	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223464779	G	TT	Indel	Pathogenic	Interstitial_lung_and_liver_disease\|Rajab_interstitial_lung_disease_with_brain_calcifications\|not_provided	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223478611	T	G	single_nucleotide_variant	Pathogenic	Cirrhosis_of_liver\|Cerebral_calcification\|Vascular_dilatation\|Interstitial_pneumonitis\|Rajab_interstitial_lung_disease_with_brain_calcifications	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223488418	C	T	single_nucleotide_variant	Pathogenic	Cirrhosis_of_liver\|Cerebral_calcification\|Vascular_dilatation\|Interstitial_pneumonitis\|Rajab_interstitial_lung_disease_with_brain_calcifications	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223488453	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FARSB	chr2	223488979	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FARSB	chr2	223489043	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223489422	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FARSB	chr2	223489481	C	T	single_nucleotide_variant	Likely_pathogenic	Rajab_interstitial_lung_disease_with_brain_calcifications\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223493603	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Rajab_interstitial_lung_disease_with_brain_calcifications	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223494831	C	T	single_nucleotide_variant	Pathogenic	Rajab_interstitial_lung_disease_with_brain_calcifications\|not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
FARSB	chr2	223496325	T	C	single_nucleotide_variant	Pathogenic	Cirrhosis_of_liver\|Cerebral_calcification\|Vascular_dilatation\|Interstitial_pneumonitis	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223496342	G	A	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Interstitial_lung_and_liver_disease\|Rajab_interstitial_lung_disease_with_brain_calcifications	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223496354	A	G	single_nucleotide_variant	Pathogenic	Cirrhosis_of_liver\|Cerebral_calcification\|Vascular_dilatation\|Interstitial_pneumonitis\|Rajab_interstitial_lung_disease_with_brain_calcifications	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223504306	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223505628	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223505643	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223507613	A	G	single_nucleotide_variant	Pathogenic	Cirrhosis_of_liver\|Cerebral_calcification\|Vascular_dilatation\|Interstitial_pneumonitis	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223507717	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FARSB	chr2	223513510	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
FARSB	LUAD	chr2	223489197	223489197	C	G	Splice_Site	p.E322_splice	4
FARSB	BRCA	chr2	223436667	223436667	G	C	Missense_Mutation	p.H565D	3
FARSB	HNSC	chr2	223497951	223497951	C	A	Missense_Mutation	p.G228C	3
FARSB	BRCA	chr2	223464670	223464670	C	T	Missense_Mutation	p.G532E	3
FARSB	PAAD	chr2	223496342	223496342	G	A	Missense_Mutation	p.T256M	3
FARSB	BRCA	chr2	223520777	223520777	C	T	Missense_Mutation	p.V6M	3
FARSB	HNSC	chr2	223497951	223497951	C	A	Missense_Mutation		3
FARSB	PAAD	chr2	223489170	223489170	G	A	Silent	p.L331L	3
FARSB	ESCA	chr2	223507641	223507641	G	A	Silent		3
FARSB	UCS	chr2	223499175	223499175	T	C	Missense_Mutation	p.I181V	3
FARSB	UCS	chr2	223513464	223513464	C	A	Nonsense_Mutation	p.E37*	2
FARSB	BLCA	chr2	223436667	223436667	G	A	Missense_Mutation	p.H565Y	2
FARSB	HNSC	chr2	223494891	223494891	T	G	Silent	p.A263A	2
FARSB	UCEC	chr2	223488401	223488401	C	T	Missense_Mutation	p.A407T	2
FARSB	STAD	chr2	223436710	223436710	C	A	Missense_Mutation	p.E550D	2
FARSB	UCEC	chr2	223493604	223493604	G	T	Silent	p.V284	2
FARSB	STAD	chr2	223478636	223478636	A	G	Silent	p.T452T	2
FARSB	HNSC	chr2	223499180	223499180	G	A	Missense_Mutation	p.S179L	2
FARSB	SARC	chr2	223497942	223497942	G	T	Missense_Mutation		2
FARSB	UCEC	chr2	223494887	223494887	T	C	Missense_Mutation	p.I265V	2
FARSB	LIHC	chr2	223505623	223505623	T	A	Silent		2
FARSB	ACC	chr2	223505606	223505607	-	TT	Frame_Shift_Ins	p.I105fs	2
FARSB	PAAD	chr2	223489170	223489170	G	A	Silent		2
FARSB	STAD	chr2	223499245	223499245	A	G	Silent	p.V157V	2
FARSB	SARC	chr2	223493573	223493573	T	C	Missense_Mutation		2
FARSB	UCEC	chr2	223504322	223504322	C	A	Missense_Mutation	p.E144D	2
FARSB	PAAD	chr2	223496342	223496342	G	A	Missense_Mutation		2
FARSB	STAD	chr2	223505594	223505594	A	C	Missense_Mutation	p.I109S	2
FARSB	HNSC	chr2	223489148	223489148	G	A	Missense_Mutation	p.S338L	2
FARSB	SARC	chr2	223493573	223493573	T	C	Missense_Mutation	p.K295E	2
FARSB	UCEC	chr2	223507595	223507595	G	A	Nonsense_Mutation	p.R82*	2
FARSB	LIHC	chr2	223494886	223494886	A	G	Missense_Mutation		2
FARSB	STAD	chr2	223488429	223488429	A	C	Silent	p.T397T	2
FARSB	UCEC	chr2	223507670	223507670	C	T	Missense_Mutation	p.A57T	2
FARSB	LIHC	chr2	223494886	223494886	A	G	Missense_Mutation	p.I265T	2
FARSB	TGCT	chr2	223507631	223507631	T	C	Missense_Mutation		2
FARSB	SKCM	chr2	223504379	223504379	A	G	Silent	p.V125V	2
FARSB	UCEC	chr2	223507698	223507698	T	G	Missense_Mutation	p.K47N	2
FARSB	ESCA	chr2	223478626	223478626	G	T	Missense_Mutation		2
FARSB	LIHC	chr2	223505623	223505623	T	A	Silent	p.V99V	2
FARSB	BLCA	chr2	223513457	223513457	A	G	Splice_Site		2
FARSB	TGCT	chr2	223507631	223507631	T	C	Missense_Mutation	p.N70D	2
FARSB	SKCM	chr2	223464667	223464667	T	A	Missense_Mutation	p.Y533F	2
FARSB	UCEC	chr2	223513509	223513509	C	T	Missense_Mutation	p.E22K	2
FARSB	ESCA	chr2	223507595	223507595	G	T	Silent		2
FARSB	LIHC	chr2	223489444	223489444	T	-	Frame_Shift_Del	p.K317fs	2
FARSB	BLCA	chr2	223496381	223496381	C	G	Missense_Mutation		2
FARSB	PRAD	chr2	223507640	223507640	C	T	Missense_Mutation	p.V67I	2
FARSB	SKCM	chr2	223499232	223499232	G	A	Missense_Mutation	p.H162Y	2
FARSB	CHOL	chr2	223497945	223497945	C	T	Missense_Mutation	p.V230I	2
FARSB	LIHC	chr2	223505607	223505607	T	-	Frame_Shift_Del	p.I105fs	2
FARSB	STAD	chr2	223436710	223436710	C	A	Missense_Mutation		2
FARSB	BLCA	chr2	223464733	223464733	A	G	Missense_Mutation	p.I511T	2
FARSB	PRAD	chr2	223499164	223499164	C	T	Silent	p.K184K	2
FARSB	SKCM	chr2	223507637	223507637	G	A	Missense_Mutation	p.P68S	2
FARSB	STAD	chr2	223507644	223507644	A	G	Silent		2
FARSB	HNSC	chr2	223520788	223520788	G	A	Missense_Mutation	p.P2L	2
FARSB	SKCM	chr2	223436631	223436631	G	A	Missense_Mutation	p.P577S	2
FARSB	STAD	chr2	223507644	223507644	A	G	Silent	p.I65I	2
FARSB	READ	chr2	223489197	223489197	C	A	Nonsense_Mutation	p.E322X	1
FARSB	COAD	chr2	223513510	223513510	G	A	Silent	p.D21D	1
FARSB	LGG	chr2	223497936	223497936	T	G	Missense_Mutation	p.M233L	1
FARSB	SKCM	chr2	223507586	223507586	G	A	Nonsense_Mutation	p.Q85X	1
FARSB	ESCA	chr2	223507641	223507641	G	A	Silent	p.D66D	1
FARSB	LUSC	chr2	223436659	223436659	G	A	Silent	p.D587D	1
FARSB	BLCA	chr2	223489020	223489020	G	C	Missense_Mutation	p.L381V	1
FARSB	HNSC	chr2	223478647	223478647	C	T	Splice_Site	p.V449_splice	1
FARSB	READ	chr2	223507716	223507716	C	A	Missense_Mutation	p.E41D	1
FARSB	COAD	chr2	223489158	223489158	A	G	Missense_Mutation	p.Y335H	1
FARSB	LGG	chr2	223436685	223436685	C	A	Missense_Mutation		1
FARSB	LIHC	chr2	223489184	223489184	T	-	Frame_Shift_Del	p.N326fs	1
FARSB	SKCM	chr2	223484396	223484396	G	A	Missense_Mutation	p.H438Y	1
FARSB	ESCA	chr2	223496323	223496323	C	A	Missense_Mutation	p.K262N	1
FARSB	OV	chr2	223464758	223464758	T	G	Missense_Mutation	p.N523H	1
FARSB	BLCA	chr2	223496381	223496381	C	G	Missense_Mutation	p.R243T	1
FARSB	DLBC	chr2	223504317	223504317	A	T	Nonsense_Mutation	p.L146X	1
FARSB	LIHC	chr2	223507646	223507646	T	-	Frame_Shift_Del	p.I65fs	1
FARSB	SKCM	chr2	223464735	223464735	G	A	Silent	p.I510I	1
FARSB	HNSC	chr2	223489148	223489148	G	A	Missense_Mutation		1
FARSB	ESCA	chr2	223478626	223478626	G	T	Missense_Mutation	p.P456T	1
FARSB	LIHC	chr2	223489482	223489482	G	T	Silent		1
FARSB	LUAD	chr2	223507723	223507723	G	A	Splice_Site	p.T39_splice	1
FARSB	SKCM	chr2	223496349	223496349	C	T	Missense_Mutation	p.E254K	1
FARSB	BLCA	chr2	223464733	223464733	A	G	Missense_Mutation		1
FARSB	HNSC	chr2	223520788	223520788	G	A	Missense_Mutation		1
FARSB	ESCA	chr2	223507595	223507595	G	T	Silent	p.R82	1
FARSB	SKCM	chr2	223484389	223484389	C	T	Missense_Mutation	p.S440N	1
FARSB	BLCA	chr2	223499122	223499122	C	T	Missense_Mutation		1
FARSB	HNSC	chr2	223494891	223494891	T	G	Silent		1
FARSB	HNSC	chr2	223497946	223497946	G	A	Silent	p.V229V	1
FARSB	SARC	chr2	223497942	223497942	G	T	Missense_Mutation	p.L231I	1
FARSB	ESCA	chr2	223507641	223507641	G	A	Silent	p.D66	1
FARSB	LUAD	chr2	223513485	223513485	C	G	Missense_Mutation	p.E30Q	1
FARSB	SKCM	chr2	223507643	223507643	C	G	Missense_Mutation	p.D66H	1
FARSB	BLCA	chr2	223436667	223436667	G	A	Missense_Mutation		1
FARSB	BRCA	chr2	223494894	223494894	C	T	Splice_Site	e9-1	1
FARSB	HNSC	chr2	223436724	223436724	C	T	Missense_Mutation	p.G546R	1
FARSB	LUAD	chr2	223513513	223513513	A	C	Splice_Site	p.T20_splice	1
FARSB	SKCM	chr2	223505621	223505621	A	G	Missense_Mutation	p.M100T	1
FARSB	HNSC	chr2	223497946	223497946	G	A	Silent		1
FARSB	PRAD	chr2	223489482	223489482	G	A	Nonsense_Mutation	p.R305X	1
FARSB	CESC	chr2	223499146	223499146	C	A	Missense_Mutation		1
FARSB	HNSC	chr2	223504411	223504411	C	A	Missense_Mutation	p.A115S	1
FARSB	LUAD	chr2	223488432	223488432	G	A	Silent	p.L396L	1
FARSB	SKCM	chr2	223507586	223507586	G	A	Nonsense_Mutation	p.Q85*	1
FARSB	HNSC	chr2	223436724	223436724	C	T	Missense_Mutation		1
FARSB	UCEC	chr2	223507595	223507595	G	A	Nonsense_Mutation	p.R102*	1
FARSB	UCS	chr2	223499175	223499175	T	C	Missense_Mutation		1
FARSB	HNSC	chr2	223496381	223496381	C	T	Missense_Mutation	p.R243K	1
FARSB	LUAD	chr2	223488993	223488993	G	A	Nonsense_Mutation	p.Q390*	1
FARSB	HNSC	chr2	223504411	223504411	C	A	Missense_Mutation		1
FARSB	UCEC	chr2	223493604	223493604	G	T	Silent	p.V304V	1
FARSB	COAD	chr2	223436672	223436672	A	G	Missense_Mutation	p.V563A	1
FARSB	LGG	chr2	223497964	223497964	G	C	Missense_Mutation	p.I223M	1
FARSB	ESCA	chr2	223496323	223496323	C	A	Missense_Mutation		1
FARSB	LIHC	chr2	223464670	223464670	C	-	Frame_Shift_Del	p.G532fs	1
FARSB	LUAD	chr2	223489197	223489197	C	G	Missense_Mutation	p.E322Q	1
FARSB	BLCA	chr2	223499122	223499122	C	T	Missense_Mutation	p.M198I	1
FARSB	PRAD	chr2	223489482	223489482	G	A	Nonsense_Mutation	p.R305*	1
FARSB	UCEC	chr2	223489074	223489074	C	T	Missense_Mutation	p.D383N	1
FARSB	COAD	chr2	223464783	223464783	G	C	Nonsense_Mutation	p.Y494X	1
FARSB	LGG	chr2	223497942	223497942	G	A	Missense_Mutation	p.L231F	1
FARSB	ESCA	chr2	223507595	223507595	G	T	Silent	p.R82R	1
FARSB	LIHC	chr2	223489174	223489174	T	-	Frame_Shift_Del	p.K329fs	1
FARSB	LUAD	chr2	223436741	223436741	C	A	Missense_Mutation	p.G540V	1

Copy number variation (CNV) of FARSB
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across FARSB
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97935	GBM	TCGA-06-5415-01A	ACSL3	chr2	223752606	+	FARSB	chr2	223436741	-
97935	N/A	DB256784	AQR	chr15	35240464	-	FARSB	chr2	223499262	-
97935	N/A	AA651740	BTBD7	chr14	93749228	-	FARSB	chr2	223436735	-
81336	BRCA	TCGA-BH-A0RX-01A	FARSB	chr2	223512699	-	ACSL3	chr2	223789312	-
81336	BRCA	TCGA-BH-A0RX-01A	FARSB	chr2	223515004	-	ACSL3	chr2	223789312	-
96482	N/A	AA628074	FARSB	chr2	223436735	+	BTBD7	chr14	93749228	+
101969	N/A	EC564944	FARSB	chr2	223436540	+	KXD1	chr19	18677935	-
98899	N/A	AI535911	FARSB	chr2	223436403	-	NELL1	chr11	20777120	-
94262	LUSC	TCGA-96-7544	FARSB	chr2	223493555	-	PHLDB2	chr3	111671418	+
97935	STAD	TCGA-CG-5721	FKBP15	chr9	115983470	-	FARSB	chr2	223436741	-
97935	STAD	TCGA-CG-5721-01A	FKBP15	chr9	115983471	-	FARSB	chr2	223436741	-
97935	SKCM	TCGA-ER-A194-01A	PAX3	chr2	223084859	-	FARSB	chr2	223464802	-
97935	N/A	DT218521	SERPINA6	chr14	94771148	+	FARSB	chr2	223513514	-
97935	COAD	TCGA-D5-5539-01A	SERPINE2	chr2	224849469	-	FARSB	chr2	223436741	-
97935	STAD	TCGA-CD-8527-01A	TSPAN3	chr15	77363234	-	FARSB	chr2	223436741	-
97943	STAD	TCGA-HU-A4G2	VAV2	chr9	136857196	-	FARSB	chr2	223484456	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	FARSB	0.00107848187068693	0.029
LUAD	FARSB	0.00794552367216228	0.21
LAML	FARSB	0.0263485286023509	0.66
TGCT	FARSB	1.46590286923425e-05	0.00041

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	FARSB	0.0179566280048441	0.5
THCA	FARSB	0.00188614313323824	0.06
KIRC	FARSB	0.00187198206585105	0.06
KICH	FARSB	0.0120794670229	0.35
LGG	FARSB	0.00778847029504828	0.23
PAAD	FARSB	9.16521129324403e-05	0.003
THYM	FARSB	0.0348655314873831	0.94

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Q9NSD9	DB00120	Phenylalanine		Small molecule	Approved\|Investigational\|Nutraceutical
Q9NSD9	DB00120	Phenylalanine

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C3150910	Brain calcification Rajab type	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
C0025958	Microcephaly	1	GENOMICS_ENGLAND