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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TOB1 (NCBI Gene ID:10140)

Gene Summary

Gene Summary

Gene Information	Gene Name: TOB1
	Gene ID: 10140
	Gene Symbol	TOB1
	Gene ID	10140
	Gene Name	transducer of ERBB2, 1
	Synonyms	APRO5\|APRO6\|PIG49\|TOB\|TROB\|TROB1
	Cytomap	17q21.33
	Type of Gene	protein-coding
	Description	protein Tob1proliferation-inducing gene 49transducer of erbB-2 1
	Modification date	20200313
	UniProtAcc	P50616

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TOB1	GO:0008285	negative regulation of cell proliferation	8632892\|19276069
Hgene	TOB1	GO:0017148	negative regulation of translation	23236473
Hgene	TOB1	GO:0060212	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	18377426
Hgene	TOB1	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	21336257
Hgene	TOB1	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	21336257

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TOB1	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'TOB1[title] AND translation [title] AND human.'

Gene	Title	PMID
TOB1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000268957	48944854	48944963	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	TOB1	-1.86894127400263	0.01953125

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UVM	TOB1	hsa-miR-218-5p	99	-0.352848101265823	0.00151661704851005

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	TOB1	0.07147098	0.015197112

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TOB1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	TOB1	AZIN1	0.80061531	1.83E-28
THYM	Cell metabolism gene	TOB1	PIK3C2A	0.802096972	1.23E-28
THYM	Cell metabolism gene	TOB1	IDH1	0.808799471	1.93E-29
THYM	Cell metabolism gene	TOB1	MINPP1	0.813550138	4.95E-30
THYM	Cell metabolism gene	TOB1	AASDHPPT	0.816389544	2.16E-30
THYM	Cell metabolism gene	TOB1	RRM2B	0.836647824	3.69E-33
THYM	Cell metabolism gene	TOB1	GPD2	0.838429343	2.02E-33
THYM	Cell metabolism gene	TOB1	LMAN1	0.843718164	3.24E-34
THYM	Cell metabolism gene	TOB1	ARFGEF2	0.867599958	3.25E-38
THYM	CGC	TOB1	MLLT10	0.805229208	5.21E-29
THYM	CGC	TOB1	IDH1	0.808799471	1.93E-29
THYM	CGC	TOB1	NBN	0.812366459	6.97E-30
THYM	CGC	TOB1	BMPR1A	0.825899272	1.20E-31
THYM	CGC	TOB1	GOLGA5	0.831086687	2.30E-32
THYM	CGC	TOB1	NFE2L2	0.844464303	2.49E-34
THYM	CGC	TOB1	PALB2	0.861436857	4.12E-37
THYM	CGC	TOB1	CLIP1	0.861772429	3.60E-37
THYM	Epifactor	TOB1	RNF2	0.801937607	1.28E-28
THYM	Epifactor	TOB1	GLYR1	0.802592978	1.07E-28
THYM	Epifactor	TOB1	MLLT10	0.805229208	5.21E-29
THYM	Epifactor	TOB1	TADA2A	0.809552342	1.56E-29
THYM	Epifactor	TOB1	NBN	0.812366459	6.97E-30
THYM	Epifactor	TOB1	JMJD1C	0.815567328	2.75E-30
THYM	Epifactor	TOB1	AEBP2	0.84461867	2.35E-34
THYM	IUPHAR	TOB1	ATP6V1A	0.800824484	1.73E-28
THYM	IUPHAR	TOB1	PIK3C2A	0.802096972	1.23E-28
THYM	IUPHAR	TOB1	CPD	0.802710032	1.04E-28
THYM	IUPHAR	TOB1	PREPL	0.804632287	6.14E-29
THYM	IUPHAR	TOB1	MAP4K3	0.804755398	5.94E-29
THYM	IUPHAR	TOB1	ACVR1B	0.8065052	3.66E-29
THYM	IUPHAR	TOB1	IDH1	0.808799471	1.93E-29
THYM	IUPHAR	TOB1	TBK1	0.809903645	1.41E-29
THYM	IUPHAR	TOB1	JMJD1C	0.815567328	2.75E-30
THYM	IUPHAR	TOB1	VRK2	0.817488742	1.56E-30
THYM	IUPHAR	TOB1	NEK4	0.818416964	1.18E-30
THYM	IUPHAR	TOB1	BMPR1A	0.825899272	1.20E-31
THYM	IUPHAR	TOB1	TWF1	0.830731981	2.58E-32
THYM	IUPHAR	TOB1	RRM2B	0.836647824	3.69E-33
THYM	IUPHAR	TOB1	SLK	0.837212319	3.05E-33
THYM	IUPHAR	TOB1	PDPK1	0.837839849	2.47E-33
THYM	IUPHAR	TOB1	NFE2L2	0.844464303	2.49E-34
THYM	IUPHAR	TOB1	SAMD8	0.846143198	1.37E-34
THYM	Kinase	TOB1	MAP4K3	0.804755398	5.94E-29
THYM	Kinase	TOB1	ACVR1B	0.8065052	3.66E-29
THYM	Kinase	TOB1	TBK1	0.809903645	1.41E-29
THYM	Kinase	TOB1	VRK2	0.817488742	1.56E-30
THYM	Kinase	TOB1	NEK4	0.818416964	1.18E-30
THYM	Kinase	TOB1	BMPR1A	0.825899272	1.20E-31
THYM	Kinase	TOB1	SLK	0.837212319	3.05E-33
THYM	Kinase	TOB1	PDPK1	0.837839849	2.47E-33
THYM	TF	TOB1	GLYR1	0.802592978	1.07E-28
THYM	TF	TOB1	ADNP2	0.805152226	5.32E-29
THYM	TF	TOB1	EEA1	0.805203508	5.25E-29
THYM	TF	TOB1	ZNF28	0.820865099	5.66E-31
THYM	TF	TOB1	ZNF664	0.832653643	1.38E-32
THYM	TF	TOB1	KLF3	0.841096942	8.08E-34
THYM	TF	TOB1	NFE2L2	0.844464303	2.49E-34
THYM	TF	TOB1	AEBP2	0.84461867	2.35E-34
THYM	TF	TOB1	HIVEP1	0.849768936	3.66E-35
THYM	TF	TOB1	NFXL1	0.858932063	1.12E-36
THYM	TSG	TOB1	IDH1	0.808799471	1.93E-29
THYM	TSG	TOB1	NBN	0.812366459	6.97E-30
THYM	TSG	TOB1	PTPN12	0.814907781	3.34E-30
THYM	TSG	TOB1	BMPR1A	0.825899272	1.20E-31
THYM	TSG	TOB1	GORAB	0.844780821	2.22E-34
THYM	TSG	TOB1	HIVEP1	0.849768936	3.66E-35
THYM	TSG	TOB1	TANK	0.849787119	3.64E-35
THYM	TSG	TOB1	PALB2	0.861436857	4.12E-37
UCS	Cell metabolism gene	TOB1	AZIN1	0.80061531	1.83E-28
UCS	Cell metabolism gene	TOB1	PIK3C2A	0.802096972	1.23E-28
UCS	Cell metabolism gene	TOB1	IDH1	0.808799471	1.93E-29
UCS	Cell metabolism gene	TOB1	MINPP1	0.813550138	4.95E-30
UCS	Cell metabolism gene	TOB1	AASDHPPT	0.816389544	2.16E-30
UCS	Cell metabolism gene	TOB1	RRM2B	0.836647824	3.69E-33
UCS	Cell metabolism gene	TOB1	GPD2	0.838429343	2.02E-33
UCS	Cell metabolism gene	TOB1	LMAN1	0.843718164	3.24E-34
UCS	Cell metabolism gene	TOB1	ARFGEF2	0.867599958	3.25E-38
UCS	CGC	TOB1	MLLT10	0.805229208	5.21E-29
UCS	CGC	TOB1	IDH1	0.808799471	1.93E-29
UCS	CGC	TOB1	NBN	0.812366459	6.97E-30
UCS	CGC	TOB1	BMPR1A	0.825899272	1.20E-31
UCS	CGC	TOB1	GOLGA5	0.831086687	2.30E-32
UCS	CGC	TOB1	NFE2L2	0.844464303	2.49E-34
UCS	CGC	TOB1	PALB2	0.861436857	4.12E-37
UCS	CGC	TOB1	CLIP1	0.861772429	3.60E-37
UCS	Epifactor	TOB1	RNF2	0.801937607	1.28E-28
UCS	Epifactor	TOB1	GLYR1	0.802592978	1.07E-28
UCS	Epifactor	TOB1	MLLT10	0.805229208	5.21E-29
UCS	Epifactor	TOB1	TADA2A	0.809552342	1.56E-29
UCS	Epifactor	TOB1	NBN	0.812366459	6.97E-30
UCS	Epifactor	TOB1	JMJD1C	0.815567328	2.75E-30
UCS	Epifactor	TOB1	AEBP2	0.84461867	2.35E-34
UCS	IUPHAR	TOB1	ATP6V1A	0.800824484	1.73E-28
UCS	IUPHAR	TOB1	PIK3C2A	0.802096972	1.23E-28
UCS	IUPHAR	TOB1	CPD	0.802710032	1.04E-28
UCS	IUPHAR	TOB1	PREPL	0.804632287	6.14E-29
UCS	IUPHAR	TOB1	MAP4K3	0.804755398	5.94E-29
UCS	IUPHAR	TOB1	ACVR1B	0.8065052	3.66E-29
UCS	IUPHAR	TOB1	IDH1	0.808799471	1.93E-29
UCS	IUPHAR	TOB1	TBK1	0.809903645	1.41E-29
UCS	IUPHAR	TOB1	JMJD1C	0.815567328	2.75E-30
UCS	IUPHAR	TOB1	VRK2	0.817488742	1.56E-30
UCS	IUPHAR	TOB1	NEK4	0.818416964	1.18E-30
UCS	IUPHAR	TOB1	BMPR1A	0.825899272	1.20E-31
UCS	IUPHAR	TOB1	TWF1	0.830731981	2.58E-32
UCS	IUPHAR	TOB1	RRM2B	0.836647824	3.69E-33
UCS	IUPHAR	TOB1	SLK	0.837212319	3.05E-33
UCS	IUPHAR	TOB1	PDPK1	0.837839849	2.47E-33
UCS	IUPHAR	TOB1	NFE2L2	0.844464303	2.49E-34
UCS	IUPHAR	TOB1	SAMD8	0.846143198	1.37E-34
UCS	Kinase	TOB1	MAP4K3	0.804755398	5.94E-29
UCS	Kinase	TOB1	ACVR1B	0.8065052	3.66E-29
UCS	Kinase	TOB1	TBK1	0.809903645	1.41E-29
UCS	Kinase	TOB1	VRK2	0.817488742	1.56E-30
UCS	Kinase	TOB1	NEK4	0.818416964	1.18E-30
UCS	Kinase	TOB1	BMPR1A	0.825899272	1.20E-31
UCS	Kinase	TOB1	SLK	0.837212319	3.05E-33
UCS	Kinase	TOB1	PDPK1	0.837839849	2.47E-33
UCS	TF	TOB1	GLYR1	0.802592978	1.07E-28
UCS	TF	TOB1	ADNP2	0.805152226	5.32E-29
UCS	TF	TOB1	EEA1	0.805203508	5.25E-29
UCS	TF	TOB1	ZNF28	0.820865099	5.66E-31
UCS	TF	TOB1	ZNF664	0.832653643	1.38E-32
UCS	TF	TOB1	KLF3	0.841096942	8.08E-34
UCS	TF	TOB1	NFE2L2	0.844464303	2.49E-34
UCS	TF	TOB1	AEBP2	0.84461867	2.35E-34
UCS	TF	TOB1	HIVEP1	0.849768936	3.66E-35
UCS	TF	TOB1	NFXL1	0.858932063	1.12E-36
UCS	TSG	TOB1	IDH1	0.808799471	1.93E-29
UCS	TSG	TOB1	NBN	0.812366459	6.97E-30
UCS	TSG	TOB1	PTPN12	0.814907781	3.34E-30
UCS	TSG	TOB1	BMPR1A	0.825899272	1.20E-31
UCS	TSG	TOB1	GORAB	0.844780821	2.22E-34
UCS	TSG	TOB1	HIVEP1	0.849768936	3.66E-35
UCS	TSG	TOB1	TANK	0.849787119	3.64E-35
UCS	TSG	TOB1	PALB2	0.861436857	4.12E-37

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	TOB1	CNOT10	-2.1943232806481	0.000121572986245155
KIRP	TOB1	CNOT6L	-3.87663737407518	0.000364991836249828
LUAD	TOB1	CNOT6L	-2.1633182779043	0.00060389239279426
ESCA	TOB1	CPEB3	-2.62322690566665	0.0009765625
KIRP	TOB1	CNOT2	-1.10448855710506	0.00222697434946895
CHOL	TOB1	CNOT8	-1.86479733449004	0.00390625
CHOL	TOB1	PABPC1	-4.56272528815353	0.00390625
HNSC	TOB1	RQCD1	1.97297540658491	0.00585215220849023
KICH	TOB1	CNOT3	-1.1461250404339	0.00882232189178467
BLCA	TOB1	PABPC1	1.31485302792746	0.0180816650390625
KICH	TOB1	CNOT8	1.5062762229379	0.0255050659179687
THCA	TOB1	CPEB3	-2.13966947208296	1.4511333759112e-09
KIRP	TOB1	CPEB3	-2.10404966038944	2.00234353542328e-08
KIRC	TOB1	CNOT10	1.29182504470331	2.23846498739956e-10
THCA	TOB1	CNOT7	-1.0100272557073	2.28966131184287e-07
LIHC	TOB1	PABPC1	-1.72076961362188	2.98009622125841e-06
LIHC	TOB1	CNOT3	-1.23300348731276	3.17814170396599e-08
STAD	TOB1	CPEB3	-1.54185853666543	4.89074736833573e-05
PRAD	TOB1	PABPC1	-2.10200318363476	8.55379952759014e-07
BRCA	TOB1	CNOT3	-2.12666858749727	9.14937084127887e-14
KIRC	TOB1	CPEB3	-2.21721784201043	9.27353127921009e-13
BRCA	TOB1	CPEB3	-1.73007606795991	9.80448817083816e-10
LIHC	TOB1	CPEB3	-2.05610354356704	9.93036701162759e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TOB1

PABPC1, CNOT7, SCMH1, SETDB1, SMAD4, SMAD5, SMAD1, SMAD9, MARCKS, MAPK1, MAPK9, RPS6KA1, SKP2, CTNNB1, SMAD3, CORO7, ELAVL1, UBR5, CHAF1A, PAN2, CDC7, DTL, APP, NXF1, CNOT1, CNOT6, CNOT6L, CNOT2, TNKS1BP1, CNOT3, RQCD1, CNOT11, CNOT8, CNOT10, RAVER1, FHL2, RNF219, ATE1, FBXL13, E6, nsp9,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TOB1	UCEC	chr17	48940553	48940556	AAAT	-	Frame_Shift_Del	p.I275fs	3
TOB1	BLCA	chr17	48940623	48940623	T	C	Silent	p.P252P	3
TOB1	BRCA	chr17	48941080	48941080	G	T	Missense_Mutation	p.S100Y	3
TOB1	ESCA	chr17	48940888	48940888	C	T	Missense_Mutation	p.S164N	3
TOB1	ESCA	chr17	48941282	48941282	C	G	Missense_Mutation	p.E33Q	3
TOB1	ESCA	chr17	48940888	48940888	C	T	Missense_Mutation		2
TOB1	LUAD	chr17	48940956	48940956	G	A	Silent	p.P141P	2
TOB1	KIRP	chr17	48940734	48940734	G	C	Missense_Mutation	p.D215E	2
TOB1	ESCA	chr17	48941282	48941282	C	G	Missense_Mutation		2
TOB1	UCEC	chr17	48940968	48940968	C	A	Missense_Mutation	p.Q137H	2
TOB1	LUAD	chr17	48941171	48941171	G	A	Nonsense_Mutation	p.Q70*	2
TOB1	UCEC	chr17	48940973	48940973	C	T	Missense_Mutation	p.A136T	2
TOB1	KIRP	chr17	48941072	48941072	T	A	Missense_Mutation	p.I103F	2
TOB1	BRCA	chr17	48940939	48940939	G	A	Missense_Mutation	p.S147L	2
TOB1	UCEC	chr17	48941243	48941243	G	A	Missense_Mutation	p.P46S	2
TOB1	BLCA	chr17	48940765	48940765	G	A	Missense_Mutation	p.S205F	2
TOB1	BRCA	chr17	48941102	48941103	-	AACACT	In_Frame_Ins	p.92in_frame_insSV	2
TOB1	STAD	chr17	48940751	48940751	C	G	Missense_Mutation		2
TOB1	BLCA	chr17	48941123	48941123	G	A	Silent	p.L86L	2
TOB1	LIHC	chr17	48941262	48941262	T	-	Frame_Shift_Del	p.K39fs	2
TOB1	STAD	chr17	48940379	48940379	A	G	Missense_Mutation	p.Y334H	2
TOB1	HNSC	chr17	48941307	48941307	A	G	Silent	p.R24R	2
TOB1	KIRP	chr17	48941072	48941072	T	A	Missense_Mutation		2
TOB1	CESC	chr17	48941308	48941308	C	T	Missense_Mutation		2
TOB1	LIHC	chr17	48940493	48940493	G	-	Frame_Shift_Del	p.L296fs	2
TOB1	BLCA	chr17	48940731	48940731	G	C	Silent		2
TOB1	KIRC	chr17	48940954	48940954	A	G	Missense_Mutation	p.I142T	2
TOB1	SARC	chr17	48940631	48940631	G	T	Missense_Mutation		2
TOB1	KIRC	chr17	48941286	48941286	T	C	Silent	p.E31E	2
TOB1	BLCA	chr17	48940731	48940731	G	C	Silent	p.L216L	2
TOB1	BLCA	chr17	48941096	48941096	C	T	Missense_Mutation	p.D95N	2
TOB1	BLCA	chr17	48940478	48940478	G	A	Missense_Mutation	p.L301F	2
TOB1	BLCA	chr17	48940478	48940478	G	A	Missense_Mutation		1
TOB1	SKCM	chr17	48941183	48941183	G	A	Missense_Mutation	p.P66S	1
TOB1	BLCA	chr17	48941203	48941206	TGTA	-	Frame_Shift_Del	p.IH58fs	1
TOB1	LIHC	chr17	48940589	48940589	T	A	Missense_Mutation	p.T264S	1
TOB1	LUAD	chr17	48941273	48941273	G	A	Missense_Mutation	p.L36F	1
TOB1	BLCA	chr17	48941033	48941033	C	T	Missense_Mutation		1
TOB1	KIRP	chr17	48940734	48940734	G	C	Missense_Mutation	p.D76E	1
TOB1	SKCM	chr17	48940550	48940550	G	A	Missense_Mutation	p.P277S	1
TOB1	BLCA	chr17	48941203	48941206	TGTA	-	Frame_Shift_Del	p.I58fs	1
TOB1	LIHC	chr17	48941376	48941376	C	A	Missense_Mutation	p.M1I	1
TOB1	GBM	chr17	48941286	48941286	T	G	Missense_Mutation		1
TOB1	LUAD	chr17	48940655	48940655	G	C	Missense_Mutation	p.Q242E	1
TOB1	LIHC	chr17	48941375	48941375	G	A	Nonsense_Mutation	p.Q2X	1
TOB1	SKCM	chr17	48940475	48940475	G	A	Nonsense_Mutation	p.Q302*	1
TOB1	HNSC	chr17	48941336	48941336	A	G	Missense_Mutation		1
TOB1	LUAD	chr17	48940480	48940480	G	A	Missense_Mutation	p.P300L	1
TOB1	KIRP	chr17	48941062	48941062	T	C	Missense_Mutation	p.K106R	1
TOB1	LIHC	chr17	48940550	48940551	-	A	Frame_Shift_Ins	p.*277fs	1
TOB1	BLCA	chr17	48940765	48940765	G	A	Missense_Mutation		1
TOB1	HNSC	chr17	48941307	48941307	A	G	Silent		1
TOB1	OV	chr17	46296048	46296049	-	A	Frame_Shift_Ins		1
TOB1	KIRP	chr17	48940734	48940734	G	C	Missense_Mutation		1
TOB1	BLCA	chr17	48941123	48941123	G	A	Silent		1
TOB1	PCPG	chr17	48940619	48940619	G	C	Missense_Mutation		1
TOB1	BLCA	chr17	48940758	48940758	G	A	Silent	p.I207I	1
TOB1	STAD	chr17	48940665	48940665	C	T	Silent	p.Q238Q	1
TOB1	KIRC	chr17	48940796	48940797	TA	-	Frame_Shift_Del	p.195_195del	1
TOB1	PRAD	chr17	48940438	48940438	C	T	Missense_Mutation	p.G314E	1
TOB1	BLCA	chr17	48940752	48940752	G	A	Silent	p.L209L	1
TOB1	LGG	chr17	48940436	48940436	C	T	Missense_Mutation	p.G315S	1
TOB1	CESC	chr17	48940521	48940521	G	T	Silent		1
TOB1	LIHC	chr17	48940514	48940514	T	-	Frame_Shift_Del	p.M289fs	1
TOB1	STAD	chr17	48940751	48940751	C	G	Missense_Mutation	p.G210R	1
TOB1	BLCA	chr17	48940752	48940752	G	A	Silent		1
TOB1	BLCA	chr17	48941243	48941243	G	T	Missense_Mutation	p.P46T	1
TOB1	LGG	chr17	48940436	48940436	C	T	Missense_Mutation		1
TOB1	COAD	chr17	48940586	48940586	A	T	Missense_Mutation	p.S126T	1
TOB1	LIHC	chr17	48940990	48940990	T	-	Frame_Shift_Del	p.N130fs	1
TOB1	TGCT	chr17	48940422	48940422	T	C	Silent		1
TOB1	BLCA	chr17	48940758	48940758	G	A	Silent		1
TOB1	SARC	chr17	48941417	48941417	C	A	Missense_Mutation		1
TOB1	LIHC	chr17	48940347	48940347	A	G	Silent		1
TOB1	LIHC	chr17	48940871	48940871	G	-	Frame_Shift_Del	p.R170fs	1
TOB1	THYM	chr17	48940395	48940395	G	T	Missense_Mutation	p.S328R	1
TOB1	BLCA	chr17	48941243	48941243	G	T	Missense_Mutation		1
TOB1	KIRC	chr17	48940796	48940797	TA	-	Frame_Shift_Del	p.NS194fs	1
TOB1	SKCM	chr17	48940475	48940475	G	A	Nonsense_Mutation	p.Q163X	1
TOB1	LIHC	chr17	48940660	48940661	-	-	Frame_Shift_Ins		1
TOB1	LIHC	chr17	48940660	48940661	-	GC	Frame_Shift_Ins	p.T240fs	1
TOB1	THYM	chr17	48940627	48940627	G	A	Missense_Mutation	p.P251L	1
TOB1	BLCA	chr17	48941096	48941096	C	T	Missense_Mutation		1
TOB1	KIRP	chr17	48940877	48940877	T	C	Missense_Mutation	p.M168V	1
TOB1	SKCM	chr17	48940550	48940550	G	A	Missense_Mutation	p.P138S	1
TOB1	LIHC	chr17	48940660	48940661	-	GC	Frame_Shift_Ins	p.P240fs	1

Copy number variation (CNV) of TOB1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TOB1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
90233	N/A	BM153377	CCDC59	chr12	82703600	-	TOB1	chr17	48939584	+
90233	N/A	EX571732	HBP1	chr7	106829799	-	TOB1	chr17	48940016	-
90233	N/A	AX381176	LRBA	chr4	151875935	-	TOB1	chr17	48939584	+
90233	BRCA	TCGA-LD-A9QF-01A	MSI2	chr17	55704664	+	TOB1	chr17	48941524	-
90233	BRCA	TCGA-LD-A9QF-01A	MSI2	chr17	55704664	-	TOB1	chr17	48944963	-
90233	N/A	AA503079	TAOK3	chr12	118704526	-	TOB1	chr17	48940606	-
90234	BRCA	TCGA-AR-A24U	TEX2	chr17	62340527	-	TOB1	chr17	48941524	-
90234	BRCA	TCGA-AR-A24U-01A	TEX2	chr17	62340528	-	TOB1	chr17	48941524	-
92968	N/A	AA010026	TOB1	chr17	48943494	-	CHMP4B	chr20	32441921	+
92968	N/A	BU603597	TOB1	chr17	48940494	-	FBXO34	chr14	55819885	+
98498	N/A	AV686332	TOB1	chr17	48940256	-	PIK3C2G	chr12	18493236	-
92968	LUAD	TCGA-50-5930-01A	TOB1	chr17	48943419	-	TTLL6	chr17	46882353	-
99580	KIRP	TCGA-DW-7839-01A	TOB1	chr17	48939584	-	UTRN	chr6	144665237	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	TOB1	0.020626835876358	0.58
SARC	TOB1	0.023332669381379	0.63

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	TOB1	0.00612591543246087	0.19
BRCA	TOB1	0.00686604292816646	0.21
ESCA	TOB1	0.00137864487057151	0.044
THYM	TOB1	0.00838661507206778	0.24
COAD	TOB1	0.0334266344934541	0.94
SARC	TOB1	0.000514091657471682	0.017

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0014175	Endometriosis	1	CTD_human
C0263454	Chloracne	1	CTD_human
C0269102	Endometrioma	1	CTD_human