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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF1B (NCBI Gene ID:10289)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF1B
	Gene ID: 10289
	Gene Symbol	EIF1B
	Gene ID	10289
	Gene Name	eukaryotic translation initiation factor 1B
	Synonyms	GC20
	Cytomap	3p22.1
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 1bprotein translation factor SUI1 homolog GC20translation factor sui1 homolog
	Modification date	20200313
	UniProtAcc	O60739

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF1B	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF1B[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF1B	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	EIF1B	-1.52296643222607	0.00467797572102414
HNSC	EIF1B	1.29022554527937	0.00540290265007571
UCEC	EIF1B	-5.93208681724707	0.046875

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF1B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
UVM	Cell metabolism gene	EIF1B	CHCHD4	0.810836869	7.88E-20
UVM	Cell metabolism gene	EIF1B	NMNAT3	0.827232274	3.20E-21
UVM	Cell metabolism gene	EIF1B	LTA4H	0.831659181	1.27E-21
UVM	Cell metabolism gene	EIF1B	PIK3R4	0.841382228	1.52E-22
UVM	CGC	EIF1B	RAF1	0.925701022	1.13E-34
UVM	Epifactor	EIF1B	UBE2E1	0.8042742	2.61E-19
UVM	Epifactor	EIF1B	WDR82	0.806963665	1.61E-19
UVM	Epifactor	EIF1B	SATB1	0.840196167	1.98E-22
UVM	IUPHAR	EIF1B	ATP2C1	0.803913803	2.78E-19
UVM	IUPHAR	EIF1B	LTA4H	0.831659181	1.27E-21
UVM	IUPHAR	EIF1B	OGG1	0.832343423	1.10E-21
UVM	IUPHAR	EIF1B	PIK3R4	0.841382228	1.52E-22
UVM	IUPHAR	EIF1B	NEK11	0.843169107	1.01E-22
UVM	IUPHAR	EIF1B	SLC25A26	0.872037909	6.44E-26
UVM	IUPHAR	EIF1B	RAF1	0.925701022	1.13E-34
UVM	Kinase	EIF1B	PIK3R4	0.841382228	1.52E-22
UVM	Kinase	EIF1B	NEK11	0.843169107	1.01E-22
UVM	Kinase	EIF1B	RAF1	0.925701022	1.13E-34
UVM	TF	EIF1B	ZXDC	0.804837401	2.36E-19
UVM	TF	EIF1B	ZNF391	0.812248107	6.06E-20
UVM	TF	EIF1B	ZNF415	0.829319167	2.08E-21
UVM	TF	EIF1B	NFIA	0.829393538	2.05E-21
UVM	TF	EIF1B	SATB1	0.840196167	1.98E-22
UVM	TF	EIF1B	ZNF667	0.842817583	1.10E-22
UVM	TF	EIF1B	ZNF835	0.882471624	2.87E-27
UVM	TSG	EIF1B	RAB7A	0.804377352	2.56E-19
UVM	TSG	EIF1B	MTUS1	0.887042017	6.67E-28

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	EIF1B	EIF3I	1.57310069220802	0.000139892101287842
LUAD	EIF1B	EIF3CL	-2.13616202681733	0.000327584192623451
PRAD	EIF1B	EIF3A	1.13680328391952	0.000363360004697762
LIHC	EIF1B	EIF3C	-1.23074521883972	0.00126327311470459
BRCA	EIF1B	EIF3I	-1.72233459275531	0.00191218761269043
LUAD	EIF1B	EIF3J	-1.1109238877878	0.00216965225011196
KICH	EIF1B	EIF2S2	-1.06278646532411	0.00308787822723389
KIRP	EIF1B	EIF3G	-2.4178322962129	0.00471024587750435
BLCA	EIF1B	EIF3A	-4.45104058307747	0.00532913208007812
LUSC	EIF1B	EIF3CL	-1.65891070592699	0.00704157337736851
BRCA	EIF1B	EIF3CL	-1.45129115344564	0.0202464785451748
HNSC	EIF1B	EIF3CL	-1.69346209598213	0.028266192551655
UCEC	EIF1B	EIF3G	-3.35078334696571	0.03125
BLCA	EIF1B	EIF3G	-3.07707559649091	0.0323410034179688
LUAD	EIF1B	EIF3B	-5.80435587546762	1.0542655358657e-09
THCA	EIF1B	EIF3J	1.32428508175103	1.19078203681914e-07
BRCA	EIF1B	EIF2S2	-2.57303037687825	1.70212120584918e-09
BRCA	EIF1B	EIF3G	1.87948385011271	1.9107949115022e-06
KIRC	EIF1B	EIF3B	-1.56313263784517	2.35252849767166e-12
STAD	EIF1B	EIF2S2	-2.13186277769467	3.17529775202275e-05
KICH	EIF1B	EIF3J	2.09716749126717	3.19480895996094e-05
STAD	EIF1B	EIF3B	-4.7724660972007	3.25962901115418e-08
HNSC	EIF1B	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	EIF1B	EIF3B	-2.7592297042974	4.6566128730774e-09
BRCA	EIF1B	EIF3A	-1.218215573148	7.39403582934137e-06
KIRP	EIF1B	EIF1AX	1.69033449545845	9.99853946268559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF1B

EIF3A, EIF3L, EIF3M, EIF3F, EIF3D, EIF3E, ACTR3, RPS11, EIF2S3, RPS3A, EIF3H, RPS9, EIF3I, RPA3, HPRT1, RPS29, YARS, SHMT2, TAGLN2, EIF3K, ERH, PCMT1, TCEB1, EIF3G, EIF2S1, TSR1, MYL12A, ACAT1, RAB7A, ELAVL1, EIF2D, ATXN1, PEX19, TRIM38, DHX9, TJP2, DVL2, TNIP2, LARP7, ATG16L1, SPG21, DVL3, CHMP4C, FZR1, GRSF1, EEF1A2, POTEI,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF1B	LIHC	chr3	40352421	40352421	C	-	Frame_Shift_Del	p.L23fs	3
EIF1B	LIHC	chr3	40353035	40353035	A	-	Frame_Shift_Del	p.R90fs	3
EIF1B	UVM	chr3	40352412	40352412	C	G	Missense_Mutation	p.D20E	3
EIF1B	LIHC	chr3	40351444	40351444	C	-	Frame_Shift_Del	p.I4fs	2
EIF1B	UCEC	chr3	40352547	40352547	G	T	Missense_Mutation	p.K65N	2
EIF1B	UVM	chr3	40352412	40352412	C	G	Missense_Mutation		2
EIF1B	LIHC	chr3	40352428	40352428	G	-	Frame_Shift_Del	p.G26fs	2
EIF1B	LUAD	chr3	40352459	40352459	A	T	Missense_Mutation	p.Q36L	2
EIF1B	UVM	chr3	40353009	40353010	-	T	Frame_Shift_Ins	p.V82fs	2
EIF1B	LUAD	chr3	40352529	40352529	T	A	Silent	p.L59L	2
EIF1B	BLCA	chr3	40352532	40352532	G	A	Silent	p.V60V	2
EIF1B	UVM	chr3	40353009	40353010	-	-	Frame_Shift_Ins		1
EIF1B	BLCA	chr3	40352532	40352532	G	A	Silent		1
EIF1B	BLCA	chr3	40352498	40352498	G	A	Missense_Mutation		1
EIF1B	UVM	chr3	40353009	40353010	-	T	Frame_Shift_Ins	p.Y82fs	1
EIF1B	LUAD	chr3	40352406	40352406	G	C	Missense_Mutation	p.K18N	1
EIF1B	BLCA	chr3	40352498	40352498	G	A	Missense_Mutation	p.G49D	1
EIF1B	LUSC	chr3	40352450	40352450	T	C	Missense_Mutation	p.I33T	1
EIF1B	CESC	chr3	40351430	40351430	C	G	Missense_Mutation		1
EIF1B	SARC	chr3	40353017	40353017	G	T	Missense_Mutation		1
EIF1B	HNSC	chr3	40353003	40353003	G	A	Missense_Mutation		1
EIF1B	SKCM	chr3	40352422	40352422	C	T	Missense_Mutation	p.P24S	1
EIF1B	HNSC	chr3	40353003	40353003	G	A	Missense_Mutation	p.G80R	1
EIF1B	SKCM	chr3	40352421	40352421	C	T	Silent	p.L23L	1

Copy number variation (CNV) of EIF1B
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF1B
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
56852	N/A	AA740716	EIF1B	chr3	40353585	-	EIF1B	chr3	40351390	+
56852	N/A	AW205722	EIF1B	chr3	40353584	-	EIF1B	chr3	40351390	+
102669	N/A	FN114103	EIF1B	chr3	40353043	-	SH3BP4	chr2	235942659	-
56855	LIHC	TCGA-DD-A116-01A	MYRIP	chr3	39942417	+	EIF1B	chr3	40351362	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	EIF1B	0.000318114276322512	0.0089
LAML	EIF1B	0.0148015597103191	0.4
LUAD	EIF1B	0.0367086212921785	0.95
KIRP	EIF1B	0.0466896174909081	1
GBM	EIF1B	0.0496775086745391	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	EIF1B	0.0230086206641211	0.69
LUSC	EIF1B	0.0337074914215358	0.94
GBM	EIF1B	0.0147243404426862	0.46
LGG	EIF1B	3.52894544599618e-06	0.00012
BRCA	EIF1B	0.0236572958515485	0.69
OV	EIF1B	0.0028687357002971	0.092
CESC	EIF1B	0.0437821002707061	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source