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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: USP16 (NCBI Gene ID:10600)

Gene Summary

Gene Summary

Gene Information	Gene Name: USP16
	Gene ID: 10600
	Gene Symbol	USP16
	Gene ID	10600
	Gene Name	ubiquitin specific peptidase 16
	Synonyms	UBP-M\|UBPM
	Cytomap	21q21.3
	Type of Gene	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 16deubiquitinating enzyme 16ubiquitin specific protease 16ubiquitin thioesterase 16ubiquitin thiolesterase 16ubiquitin-processing protease UBP-Mubiquitin-specific processing protease 16
	Modification date	20200313
	UniProtAcc	Q9Y5T5

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	USP16	GO:0000278	mitotic cell cycle	17914355
Hgene	USP16	GO:0006974	cellular response to DNA damage stimulus	20550933
Hgene	USP16	GO:0016578	histone deubiquitination	17914355

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
USP16	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'USP16[title] AND translation [title] AND human.'

Gene	Title	PMID
USP16	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000334352	30398029	30398092	5UTR-5UTR
ENST00000399976	30400193	30400295	5CDS-5UTR
ENST00000334352	30409596	30409784	Frame-shift
ENST00000399976	30409596	30409784	Frame-shift
ENST00000334352	30412929	30413008	Frame-shift
ENST00000399976	30412929	30413008	Frame-shift
ENST00000334352	30415743	30415920	In-frame
ENST00000399976	30415743	30415920	In-frame
ENST00000334352	30421081	30421176	Frame-shift
ENST00000399976	30421081	30421176	Frame-shift
ENST00000334352	30422412	30422499	In-frame
ENST00000399976	30422412	30422499	In-frame
ENST00000334352	30426122	30426279	Frame-shift
ENST00000399976	30426122	30426279	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000399976	30415743	30415920	2980	1370	1546	823	393	452
ENST00000334352	30415743	30415920	3021	1411	1587	823	393	452
ENST00000399976	30422412	30422499	2980	2297	2383	823	702	731
ENST00000334352	30422412	30422499	3021	2338	2424	823	702	731

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	USP16	-1.36184823725158	0.00471395891927286
KIRP	USP16	2.15967928046073	2.98023223876953e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CESC	USP16	0.077199756	0.029575012
SKCM	USP16	0.05994017	0.032734956

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with USP16 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	USP16	NUPL1	0.801181785	7.98E-12
DLBC	Cell metabolism gene	USP16	LMAN1	0.832868639	2.12E-13
DLBC	Cell metabolism gene	USP16	XRN2	0.842147579	6.33E-14
DLBC	CGC	USP16	SUZ12	0.802514867	6.94E-12
DLBC	CGC	USP16	PTPN11	0.815050781	1.78E-12
DLBC	Epifactor	USP16	SUZ12	0.802514867	6.94E-12
DLBC	Epifactor	USP16	SMARCAD1	0.805458262	5.08E-12
DLBC	TF	USP16	SP2	0.800417276	8.64E-12
DLBC	TF	USP16	NFXL1	0.803369604	6.34E-12
DLBC	TSG	USP16	SUZ12	0.802514867	6.94E-12
DLBC	TSG	USP16	PTPN11	0.815050781	1.78E-12
KIRP	TF	USP16	GABPA	0.830829373	1.07E-83
SKCM	CGC	USP16	KTN1	0.800746559	4.05E-107
SKCM	Epifactor	USP16	BRWD1	0.838319482	1.94E-126
SKCM	IUPHAR	USP16	BRWD1	0.838319482	1.94E-126
SKCM	TF	USP16	MYNN	0.809694869	2.52E-111
SKCM	TF	USP16	ZNF148	0.815466835	3.70E-114
SKCM	TF	USP16	TMF1	0.817611674	3.09E-115
SKCM	TF	USP16	ZBTB11	0.824438797	9.12E-119
SKCM	TF	USP16	GABPA	0.861500645	5.00E-141
TGCT	CGC	USP16	USP8	0.82600564	3.52E-40
TGCT	Epifactor	USP16	TLK1	0.802151321	2.60E-36
TGCT	IUPHAR	USP16	TLK1	0.802151321	2.60E-36
TGCT	IUPHAR	USP16	SLC12A6	0.811926599	7.88E-38
TGCT	Kinase	USP16	TLK1	0.802151321	2.60E-36
TGCT	TF	USP16	ZNF304	0.802505893	2.30E-36
THCA	Epifactor	USP16	ZMYND11	0.815294748	2.28E-137
THCA	IUPHAR	USP16	RPS6KA6	0.804572577	4.12E-131
THCA	IUPHAR	USP16	ZMYND11	0.815294748	2.28E-137
THCA	IUPHAR	USP16	SLC33A1	0.821464783	3.72E-141
THCA	Kinase	USP16	RPS6KA6	0.804572577	4.12E-131
THCA	TSG	USP16	RPS6KA6	0.804572577	4.12E-131
THCA	TSG	USP16	ZMYND11	0.815294748	2.28E-137
THYM	Cell metabolism gene	USP16	PIK3R4	0.800465922	1.91E-28
THYM	Cell metabolism gene	USP16	PI4K2B	0.802260402	1.17E-28
THYM	Cell metabolism gene	USP16	CSGALNACT2	0.803582227	8.19E-29
THYM	Cell metabolism gene	USP16	SRP54	0.803748801	7.83E-29
THYM	Cell metabolism gene	USP16	MED13L	0.806272889	3.90E-29
THYM	Cell metabolism gene	USP16	AASDHPPT	0.807777922	2.57E-29
THYM	Cell metabolism gene	USP16	SYNJ1	0.808153944	2.31E-29
THYM	Cell metabolism gene	USP16	FBXW2	0.80945363	1.60E-29
THYM	Cell metabolism gene	USP16	PIP5K1A	0.818905848	1.02E-30
THYM	Cell metabolism gene	USP16	MED14	0.819750875	7.93E-31
THYM	Cell metabolism gene	USP16	XRN2	0.81991628	7.54E-31
THYM	Cell metabolism gene	USP16	GLS	0.821262536	5.02E-31
THYM	Cell metabolism gene	USP16	MUT	0.821947059	4.07E-31
THYM	Cell metabolism gene	USP16	B3GNT2	0.823988273	2.18E-31
THYM	Cell metabolism gene	USP16	MANEA	0.825627346	1.31E-31
THYM	Cell metabolism gene	USP16	NUP107	0.826193676	1.10E-31
THYM	Cell metabolism gene	USP16	PIKFYVE	0.832943453	1.26E-32
THYM	Cell metabolism gene	USP16	NUPL1	0.833354465	1.10E-32
THYM	Cell metabolism gene	USP16	TGS1	0.836410154	3.99E-33
THYM	Cell metabolism gene	USP16	NUP54	0.83687439	3.41E-33
THYM	Cell metabolism gene	USP16	PNPLA8	0.838593891	1.91E-33
THYM	Cell metabolism gene	USP16	TRMT11	0.839637943	1.34E-33
THYM	Cell metabolism gene	USP16	MAT2B	0.849406864	4.18E-35
THYM	Cell metabolism gene	USP16	MTM1	0.849686137	3.77E-35
THYM	Cell metabolism gene	USP16	SEC24B	0.852452942	1.35E-35
THYM	Cell metabolism gene	USP16	NUP153	0.853687845	8.47E-36
THYM	Cell metabolism gene	USP16	BCKDHB	0.856701799	2.67E-36
THYM	Cell metabolism gene	USP16	MTMR6	0.856933176	2.44E-36
THYM	Cell metabolism gene	USP16	RQCD1	0.861452962	4.09E-37
THYM	Cell metabolism gene	USP16	CDK8	0.874016964	2.01E-39
THYM	Cell metabolism gene	USP16	ACADM	0.874185958	1.87E-39
THYM	Cell metabolism gene	USP16	POLR2B	0.891961659	3.46E-43
THYM	Cell metabolism gene	USP16	MED17	0.911284389	4.58E-48
THYM	CGC	USP16	ABI1	0.800049035	2.13E-28
THYM	CGC	USP16	BIRC6	0.800213876	2.04E-28
THYM	CGC	USP16	BCOR	0.810104084	1.33E-29
THYM	CGC	USP16	NUP98	0.810281726	1.27E-29
THYM	CGC	USP16	TCEA1	0.811857042	8.07E-30
THYM	CGC	USP16	ATR	0.813641029	4.82E-30
THYM	CGC	USP16	RAF1	0.815662585	2.67E-30
THYM	CGC	USP16	BRCA2	0.816977131	1.81E-30
THYM	CGC	USP16	BCLAF1	0.819776522	7.87E-31
THYM	CGC	USP16	VHL	0.819939152	7.49E-31
THYM	CGC	USP16	GOPC	0.830475538	2.81E-32
THYM	CGC	USP16	STAG1	0.838157066	2.21E-33
THYM	CGC	USP16	ZCCHC8	0.85002735	3.33E-35
THYM	CGC	USP16	TRRAP	0.850160969	3.17E-35
THYM	CGC	USP16	SETD2	0.853695999	8.44E-36
THYM	CGC	USP16	PWWP2A	0.858403362	1.37E-36
THYM	CGC	USP16	CREB1	0.85926021	9.81E-37
THYM	CGC	USP16	SF3B1	0.863255691	1.97E-37
THYM	CGC	USP16	RAD21	0.863959931	1.48E-37
THYM	CGC	USP16	MLLT10	0.864823165	1.04E-37
THYM	CGC	USP16	RB1	0.867532626	3.35E-38
THYM	CGC	USP16	FUBP1	0.870307692	1.02E-38
THYM	CGC	USP16	ATF1	0.878570801	2.54E-40
THYM	CGC	USP16	TOP1	0.884042166	1.89E-41
THYM	Epifactor	USP16	TADA2A	0.803438419	8.52E-29
THYM	Epifactor	USP16	SENP1	0.803580509	8.20E-29
THYM	Epifactor	USP16	ATAD2B	0.804578601	6.23E-29
THYM	Epifactor	USP16	UCHL5	0.805461246	4.89E-29
THYM	Epifactor	USP16	ZRANB3	0.806946823	3.24E-29
THYM	Epifactor	USP16	JMJD1C	0.807061459	3.13E-29
THYM	Epifactor	USP16	TADA1	0.807284927	2.94E-29
THYM	Epifactor	USP16	AEBP2	0.807318974	2.92E-29
THYM	Epifactor	USP16	HMG20A	0.808426744	2.14E-29
THYM	Epifactor	USP16	ANKRD32	0.809384824	1.63E-29
THYM	Epifactor	USP16	BCOR	0.810104084	1.33E-29
THYM	Epifactor	USP16	HCFC2	0.810217368	1.29E-29
THYM	Epifactor	USP16	INO80D	0.81041944	1.22E-29
THYM	Epifactor	USP16	ATR	0.813641029	4.82E-30
THYM	Epifactor	USP16	HLTF	0.815021737	3.23E-30
THYM	Epifactor	USP16	WDR82	0.815545162	2.77E-30
THYM	Epifactor	USP16	BRCA2	0.816977131	1.81E-30
THYM	Epifactor	USP16	C11orf30	0.818674641	1.09E-30
THYM	Epifactor	USP16	ATXN7	0.819643957	8.19E-31
THYM	Epifactor	USP16	NIPBL	0.819685807	8.08E-31
THYM	Epifactor	USP16	ADNP	0.819971337	7.42E-31
THYM	Epifactor	USP16	RLIM	0.820486706	6.35E-31
THYM	Epifactor	USP16	KDM3A	0.820697279	5.96E-31
THYM	Epifactor	USP16	WAC	0.827887731	6.42E-32
THYM	Epifactor	USP16	SMARCA5	0.829815052	3.47E-32
THYM	Epifactor	USP16	MAP3K7	0.832832042	1.31E-32
THYM	Epifactor	USP16	RCOR1	0.833099963	1.20E-32
THYM	Epifactor	USP16	ARID4A	0.841223101	7.74E-34
THYM	Epifactor	USP16	SIRT1	0.842334271	5.26E-34
THYM	Epifactor	USP16	PHF20L1	0.847616192	8.03E-35
THYM	Epifactor	USP16	TRRAP	0.850160969	3.17E-35
THYM	Epifactor	USP16	SETD2	0.853695999	8.44E-36
THYM	Epifactor	USP16	EPC1	0.855951876	3.57E-36
THYM	Epifactor	USP16	YY1	0.856564887	2.81E-36
THYM	Epifactor	USP16	ING3	0.85697607	2.40E-36
THYM	Epifactor	USP16	DR1	0.857261682	2.15E-36
THYM	Epifactor	USP16	ZNF217	0.859135646	1.03E-36
THYM	Epifactor	USP16	SF3B1	0.863255691	1.97E-37
THYM	Epifactor	USP16	MLLT10	0.864823165	1.04E-37
THYM	Epifactor	USP16	RB1	0.867532626	3.35E-38
THYM	Epifactor	USP16	RBBP4	0.871480898	6.16E-39
THYM	Epifactor	USP16	SMEK2	0.88093373	8.42E-41
THYM	Epifactor	USP16	SMARCAD1	0.893664156	1.41E-43
THYM	Epifactor	USP16	CTR9	0.894479467	9.09E-44
THYM	Epifactor	USP16	TAF2	0.899090675	7.17E-45
THYM	IUPHAR	USP16	BIRC6	0.800213876	2.04E-28
THYM	IUPHAR	USP16	SENP7	0.800353759	1.96E-28
THYM	IUPHAR	USP16	PIK3R4	0.800465922	1.91E-28
THYM	IUPHAR	USP16	PI4K2B	0.802260402	1.17E-28
THYM	IUPHAR	USP16	SENP1	0.803580509	8.20E-29
THYM	IUPHAR	USP16	SLC25A46	0.804163101	6.99E-29
THYM	IUPHAR	USP16	NEK7	0.804574513	6.24E-29
THYM	IUPHAR	USP16	ATAD2B	0.804578601	6.23E-29
THYM	IUPHAR	USP16	JMJD1C	0.807061459	3.13E-29
THYM	IUPHAR	USP16	SCYL2	0.807846165	2.52E-29
THYM	IUPHAR	USP16	SYNJ1	0.808153944	2.31E-29
THYM	IUPHAR	USP16	ATR	0.813641029	4.82E-30
THYM	IUPHAR	USP16	ADAM10	0.813722649	4.71E-30
THYM	IUPHAR	USP16	RAF1	0.815662585	2.67E-30
THYM	IUPHAR	USP16	PIP5K1A	0.818905848	1.02E-30
THYM	IUPHAR	USP16	KDM3A	0.820697279	5.96E-31
THYM	IUPHAR	USP16	GLS	0.821262536	5.02E-31
THYM	IUPHAR	USP16	MAP3K7	0.832832042	1.31E-32
THYM	IUPHAR	USP16	PIKFYVE	0.832943453	1.26E-32
THYM	IUPHAR	USP16	TPP2	0.83457793	7.35E-33
THYM	IUPHAR	USP16	NEK4	0.834581574	7.34E-33
THYM	IUPHAR	USP16	PRMT3	0.83727972	2.98E-33
THYM	IUPHAR	USP16	MAPK8	0.841698238	6.56E-34
THYM	IUPHAR	USP16	HIPK1	0.841827006	6.28E-34
THYM	IUPHAR	USP16	SIRT1	0.842334271	5.26E-34
THYM	IUPHAR	USP16	DYRK1A	0.846188457	1.34E-34
THYM	IUPHAR	USP16	TRRAP	0.850160969	3.17E-35
THYM	IUPHAR	USP16	SETD2	0.853695999	8.44E-36
THYM	IUPHAR	USP16	NR2C2	0.873707688	2.31E-39
THYM	IUPHAR	USP16	CDK8	0.874016964	2.01E-39
THYM	IUPHAR	USP16	TNKS2	0.876760976	5.85E-40
THYM	IUPHAR	USP16	SLC35A3	0.880436629	1.06E-40
THYM	IUPHAR	USP16	TOP1	0.884042166	1.89E-41
THYM	Kinase	USP16	PIK3R4	0.800465922	1.91E-28
THYM	Kinase	USP16	NEK7	0.804574513	6.24E-29
THYM	Kinase	USP16	SCYL2	0.807846165	2.52E-29
THYM	Kinase	USP16	ATR	0.813641029	4.82E-30
THYM	Kinase	USP16	RAF1	0.815662585	2.67E-30
THYM	Kinase	USP16	MAP3K7	0.832832042	1.31E-32
THYM	Kinase	USP16	NEK4	0.834581574	7.34E-33
THYM	Kinase	USP16	PAN3	0.839689401	1.31E-33
THYM	Kinase	USP16	MAPK8	0.841698238	6.56E-34
THYM	Kinase	USP16	HIPK1	0.841827006	6.28E-34
THYM	Kinase	USP16	DYRK1A	0.846188457	1.34E-34
THYM	Kinase	USP16	TRRAP	0.850160969	3.17E-35
THYM	Kinase	USP16	CDK8	0.874016964	2.01E-39
THYM	TF	USP16	SP2	0.800448322	1.92E-28
THYM	TF	USP16	ZNF675	0.801006859	1.65E-28
THYM	TF	USP16	ZNF518A	0.801032582	1.64E-28
THYM	TF	USP16	ZNF235	0.803104791	9.33E-29
THYM	TF	USP16	ZNF318	0.803163849	9.19E-29
THYM	TF	USP16	ELF2	0.804437274	6.48E-29
THYM	TF	USP16	GPBP1L1	0.804859838	5.77E-29
THYM	TF	USP16	ZFP91	0.805372169	5.01E-29
THYM	TF	USP16	ZNF146	0.806310985	3.86E-29
THYM	TF	USP16	ZNF254	0.806516293	3.65E-29
THYM	TF	USP16	AEBP2	0.807318974	2.92E-29
THYM	TF	USP16	HMG20A	0.808426744	2.14E-29
THYM	TF	USP16	ZBTB39	0.812506313	6.70E-30
THYM	TF	USP16	ZFP30	0.814443098	3.82E-30
THYM	TF	USP16	FOXJ3	0.814563209	3.69E-30
THYM	TF	USP16	ZNF800	0.816005017	2.42E-30
THYM	TF	USP16	ADNP	0.819971337	7.42E-31
THYM	TF	USP16	ZUFSP	0.82062064	6.10E-31
THYM	TF	USP16	CDC5L	0.823080952	2.88E-31
THYM	TF	USP16	ZNF227	0.824222724	2.02E-31
THYM	TF	USP16	ZNF184	0.825512167	1.36E-31
THYM	TF	USP16	TOPORS	0.828358942	5.53E-32
THYM	TF	USP16	CREBZF	0.829216545	4.21E-32
THYM	TF	USP16	ZNF680	0.830787981	2.54E-32
THYM	TF	USP16	ZFX	0.831182268	2.23E-32
THYM	TF	USP16	ZNF708	0.833089508	1.20E-32
THYM	TF	USP16	ZNF136	0.833168525	1.17E-32
THYM	TF	USP16	PRMT3	0.83727972	2.98E-33
THYM	TF	USP16	ZNF430	0.841974156	5.96E-34
THYM	TF	USP16	ZBTB1	0.843366766	3.66E-34
THYM	TF	USP16	ZNF28	0.845279461	1.86E-34
THYM	TF	USP16	ZBTB11	0.850133756	3.20E-35
THYM	TF	USP16	ZNF468	0.850482091	2.81E-35
THYM	TF	USP16	ZNF143	0.852282913	1.44E-35
THYM	TF	USP16	ZNF225	0.856110486	3.35E-36
THYM	TF	USP16	ZNF627	0.856440194	2.95E-36
THYM	TF	USP16	YY1	0.856564887	2.81E-36
THYM	TF	USP16	DR1	0.857261682	2.15E-36
THYM	TF	USP16	ZNF765	0.858392708	1.38E-36
THYM	TF	USP16	ZNF217	0.859135646	1.03E-36
THYM	TF	USP16	CREB1	0.85926021	9.81E-37
THYM	TF	USP16	RLF	0.873399477	2.65E-39
THYM	TF	USP16	NR2C2	0.873707688	2.31E-39
THYM	TF	USP16	ATF1	0.878570801	2.54E-40
THYM	TF	USP16	SP4	0.885569331	8.96E-42
THYM	TF	USP16	ZNF567	0.886080725	6.96E-42
THYM	TF	USP16	ZNF776	0.892500432	2.61E-43
THYM	TF	USP16	SP3	0.893593133	1.46E-43
THYM	TF	USP16	ELF1	0.909386359	1.54E-47
THYM	TSG	USP16	GGNBP2	0.802881205	9.92E-29
THYM	TSG	USP16	NUP98	0.810281726	1.27E-29
THYM	TSG	USP16	ATR	0.813641029	4.82E-30
THYM	TSG	USP16	HLTF	0.815021737	3.23E-30
THYM	TSG	USP16	BRCA2	0.816977131	1.81E-30
THYM	TSG	USP16	VHL	0.819939152	7.49E-31
THYM	TSG	USP16	KDM3A	0.820697279	5.96E-31
THYM	TSG	USP16	LIN9	0.827889219	6.42E-32
THYM	TSG	USP16	TOPORS	0.828358942	5.53E-32
THYM	TSG	USP16	INTS6	0.830491762	2.79E-32
THYM	TSG	USP16	TANK	0.833373043	1.09E-32
THYM	TSG	USP16	CCAR1	0.83632997	4.10E-33
THYM	TSG	USP16	SIRT1	0.842334271	5.26E-34
THYM	TSG	USP16	RANBP9	0.84877631	5.27E-35
THYM	TSG	USP16	EAF1	0.851709473	1.78E-35
THYM	TSG	USP16	SETD2	0.853695999	8.44E-36
THYM	TSG	USP16	RB1CC1	0.853752685	8.26E-36
THYM	TSG	USP16	ING3	0.85697607	2.40E-36
THYM	TSG	USP16	RB1	0.867532626	3.35E-38
THYM	TSG	USP16	NR2C2	0.873707688	2.31E-39
THYM	TSG	USP16	RBL2	0.880940045	8.39E-41
THYM	TSG	USP16	HACE1	0.882082036	4.88E-41
UCEC	TF	USP16	GABPA	0.819495701	5.28E-50
UCS	Cell metabolism gene	USP16	PIK3R4	0.800465922	1.91E-28
UCS	Cell metabolism gene	USP16	PI4K2B	0.802260402	1.17E-28
UCS	Cell metabolism gene	USP16	CSGALNACT2	0.803582227	8.19E-29
UCS	Cell metabolism gene	USP16	SRP54	0.803748801	7.83E-29
UCS	Cell metabolism gene	USP16	MED13L	0.806272889	3.90E-29
UCS	Cell metabolism gene	USP16	AASDHPPT	0.807777922	2.57E-29
UCS	Cell metabolism gene	USP16	SYNJ1	0.808153944	2.31E-29
UCS	Cell metabolism gene	USP16	FBXW2	0.80945363	1.60E-29
UCS	Cell metabolism gene	USP16	PIP5K1A	0.818905848	1.02E-30
UCS	Cell metabolism gene	USP16	MED14	0.819750875	7.93E-31
UCS	Cell metabolism gene	USP16	XRN2	0.81991628	7.54E-31
UCS	Cell metabolism gene	USP16	GLS	0.821262536	5.02E-31
UCS	Cell metabolism gene	USP16	MUT	0.821947059	4.07E-31
UCS	Cell metabolism gene	USP16	B3GNT2	0.823988273	2.18E-31
UCS	Cell metabolism gene	USP16	MANEA	0.825627346	1.31E-31
UCS	Cell metabolism gene	USP16	NUP107	0.826193676	1.10E-31
UCS	Cell metabolism gene	USP16	PIKFYVE	0.832943453	1.26E-32
UCS	Cell metabolism gene	USP16	NUPL1	0.833354465	1.10E-32
UCS	Cell metabolism gene	USP16	TGS1	0.836410154	3.99E-33
UCS	Cell metabolism gene	USP16	NUP54	0.83687439	3.41E-33
UCS	Cell metabolism gene	USP16	PNPLA8	0.838593891	1.91E-33
UCS	Cell metabolism gene	USP16	TRMT11	0.839637943	1.34E-33
UCS	Cell metabolism gene	USP16	MAT2B	0.849406864	4.18E-35
UCS	Cell metabolism gene	USP16	MTM1	0.849686137	3.77E-35
UCS	Cell metabolism gene	USP16	SEC24B	0.852452942	1.35E-35
UCS	Cell metabolism gene	USP16	NUP153	0.853687845	8.47E-36
UCS	Cell metabolism gene	USP16	BCKDHB	0.856701799	2.67E-36
UCS	Cell metabolism gene	USP16	MTMR6	0.856933176	2.44E-36
UCS	Cell metabolism gene	USP16	RQCD1	0.861452962	4.09E-37
UCS	Cell metabolism gene	USP16	CDK8	0.874016964	2.01E-39
UCS	Cell metabolism gene	USP16	ACADM	0.874185958	1.87E-39
UCS	Cell metabolism gene	USP16	POLR2B	0.891961659	3.46E-43
UCS	Cell metabolism gene	USP16	MED17	0.911284389	4.58E-48
UCS	CGC	USP16	ABI1	0.800049035	2.13E-28
UCS	CGC	USP16	BIRC6	0.800213876	2.04E-28
UCS	CGC	USP16	BCOR	0.810104084	1.33E-29
UCS	CGC	USP16	NUP98	0.810281726	1.27E-29
UCS	CGC	USP16	TCEA1	0.811857042	8.07E-30
UCS	CGC	USP16	ATR	0.813641029	4.82E-30
UCS	CGC	USP16	RAF1	0.815662585	2.67E-30
UCS	CGC	USP16	BRCA2	0.816977131	1.81E-30
UCS	CGC	USP16	BCLAF1	0.819776522	7.87E-31
UCS	CGC	USP16	VHL	0.819939152	7.49E-31
UCS	CGC	USP16	GOPC	0.830475538	2.81E-32
UCS	CGC	USP16	STAG1	0.838157066	2.21E-33
UCS	CGC	USP16	ZCCHC8	0.85002735	3.33E-35
UCS	CGC	USP16	TRRAP	0.850160969	3.17E-35
UCS	CGC	USP16	SETD2	0.853695999	8.44E-36
UCS	CGC	USP16	PWWP2A	0.858403362	1.37E-36
UCS	CGC	USP16	CREB1	0.85926021	9.81E-37
UCS	CGC	USP16	SF3B1	0.863255691	1.97E-37
UCS	CGC	USP16	RAD21	0.863959931	1.48E-37
UCS	CGC	USP16	MLLT10	0.864823165	1.04E-37
UCS	CGC	USP16	RB1	0.867532626	3.35E-38
UCS	CGC	USP16	FUBP1	0.870307692	1.02E-38
UCS	CGC	USP16	ATF1	0.878570801	2.54E-40
UCS	CGC	USP16	TOP1	0.884042166	1.89E-41
UCS	Epifactor	USP16	TADA2A	0.803438419	8.52E-29
UCS	Epifactor	USP16	SENP1	0.803580509	8.20E-29
UCS	Epifactor	USP16	ATAD2B	0.804578601	6.23E-29
UCS	Epifactor	USP16	UCHL5	0.805461246	4.89E-29
UCS	Epifactor	USP16	ZRANB3	0.806946823	3.24E-29
UCS	Epifactor	USP16	JMJD1C	0.807061459	3.13E-29
UCS	Epifactor	USP16	TADA1	0.807284927	2.94E-29
UCS	Epifactor	USP16	AEBP2	0.807318974	2.92E-29
UCS	Epifactor	USP16	HMG20A	0.808426744	2.14E-29
UCS	Epifactor	USP16	ANKRD32	0.809384824	1.63E-29
UCS	Epifactor	USP16	BCOR	0.810104084	1.33E-29
UCS	Epifactor	USP16	HCFC2	0.810217368	1.29E-29
UCS	Epifactor	USP16	INO80D	0.81041944	1.22E-29
UCS	Epifactor	USP16	ATR	0.813641029	4.82E-30
UCS	Epifactor	USP16	HLTF	0.815021737	3.23E-30
UCS	Epifactor	USP16	WDR82	0.815545162	2.77E-30
UCS	Epifactor	USP16	BRCA2	0.816977131	1.81E-30
UCS	Epifactor	USP16	C11orf30	0.818674641	1.09E-30
UCS	Epifactor	USP16	ATXN7	0.819643957	8.19E-31
UCS	Epifactor	USP16	NIPBL	0.819685807	8.08E-31
UCS	Epifactor	USP16	ADNP	0.819971337	7.42E-31
UCS	Epifactor	USP16	RLIM	0.820486706	6.35E-31
UCS	Epifactor	USP16	KDM3A	0.820697279	5.96E-31
UCS	Epifactor	USP16	WAC	0.827887731	6.42E-32
UCS	Epifactor	USP16	SMARCA5	0.829815052	3.47E-32
UCS	Epifactor	USP16	MAP3K7	0.832832042	1.31E-32
UCS	Epifactor	USP16	RCOR1	0.833099963	1.20E-32
UCS	Epifactor	USP16	ARID4A	0.841223101	7.74E-34
UCS	Epifactor	USP16	SIRT1	0.842334271	5.26E-34
UCS	Epifactor	USP16	PHF20L1	0.847616192	8.03E-35
UCS	Epifactor	USP16	TRRAP	0.850160969	3.17E-35
UCS	Epifactor	USP16	SETD2	0.853695999	8.44E-36
UCS	Epifactor	USP16	EPC1	0.855951876	3.57E-36
UCS	Epifactor	USP16	YY1	0.856564887	2.81E-36
UCS	Epifactor	USP16	ING3	0.85697607	2.40E-36
UCS	Epifactor	USP16	DR1	0.857261682	2.15E-36
UCS	Epifactor	USP16	ZNF217	0.859135646	1.03E-36
UCS	Epifactor	USP16	SF3B1	0.863255691	1.97E-37
UCS	Epifactor	USP16	MLLT10	0.864823165	1.04E-37
UCS	Epifactor	USP16	RB1	0.867532626	3.35E-38
UCS	Epifactor	USP16	RBBP4	0.871480898	6.16E-39
UCS	Epifactor	USP16	SMEK2	0.88093373	8.42E-41
UCS	Epifactor	USP16	SMARCAD1	0.893664156	1.41E-43
UCS	Epifactor	USP16	CTR9	0.894479467	9.09E-44
UCS	Epifactor	USP16	TAF2	0.899090675	7.17E-45
UCS	IUPHAR	USP16	BIRC6	0.800213876	2.04E-28
UCS	IUPHAR	USP16	SENP7	0.800353759	1.96E-28
UCS	IUPHAR	USP16	PIK3R4	0.800465922	1.91E-28
UCS	IUPHAR	USP16	PI4K2B	0.802260402	1.17E-28
UCS	IUPHAR	USP16	SENP1	0.803580509	8.20E-29
UCS	IUPHAR	USP16	SLC25A46	0.804163101	6.99E-29
UCS	IUPHAR	USP16	NEK7	0.804574513	6.24E-29
UCS	IUPHAR	USP16	ATAD2B	0.804578601	6.23E-29
UCS	IUPHAR	USP16	JMJD1C	0.807061459	3.13E-29
UCS	IUPHAR	USP16	SCYL2	0.807846165	2.52E-29
UCS	IUPHAR	USP16	SYNJ1	0.808153944	2.31E-29
UCS	IUPHAR	USP16	ATR	0.813641029	4.82E-30
UCS	IUPHAR	USP16	ADAM10	0.813722649	4.71E-30
UCS	IUPHAR	USP16	RAF1	0.815662585	2.67E-30
UCS	IUPHAR	USP16	PIP5K1A	0.818905848	1.02E-30
UCS	IUPHAR	USP16	KDM3A	0.820697279	5.96E-31
UCS	IUPHAR	USP16	GLS	0.821262536	5.02E-31
UCS	IUPHAR	USP16	MAP3K7	0.832832042	1.31E-32
UCS	IUPHAR	USP16	PIKFYVE	0.832943453	1.26E-32
UCS	IUPHAR	USP16	TPP2	0.83457793	7.35E-33
UCS	IUPHAR	USP16	NEK4	0.834581574	7.34E-33
UCS	IUPHAR	USP16	PRMT3	0.83727972	2.98E-33
UCS	IUPHAR	USP16	MAPK8	0.841698238	6.56E-34
UCS	IUPHAR	USP16	HIPK1	0.841827006	6.28E-34
UCS	IUPHAR	USP16	SIRT1	0.842334271	5.26E-34
UCS	IUPHAR	USP16	DYRK1A	0.846188457	1.34E-34
UCS	IUPHAR	USP16	TRRAP	0.850160969	3.17E-35
UCS	IUPHAR	USP16	SETD2	0.853695999	8.44E-36
UCS	IUPHAR	USP16	NR2C2	0.873707688	2.31E-39
UCS	IUPHAR	USP16	CDK8	0.874016964	2.01E-39
UCS	IUPHAR	USP16	TNKS2	0.876760976	5.85E-40
UCS	IUPHAR	USP16	SLC35A3	0.880436629	1.06E-40
UCS	IUPHAR	USP16	TOP1	0.884042166	1.89E-41
UCS	Kinase	USP16	PIK3R4	0.800465922	1.91E-28
UCS	Kinase	USP16	NEK7	0.804574513	6.24E-29
UCS	Kinase	USP16	SCYL2	0.807846165	2.52E-29
UCS	Kinase	USP16	ATR	0.813641029	4.82E-30
UCS	Kinase	USP16	RAF1	0.815662585	2.67E-30
UCS	Kinase	USP16	MAP3K7	0.832832042	1.31E-32
UCS	Kinase	USP16	NEK4	0.834581574	7.34E-33
UCS	Kinase	USP16	PAN3	0.839689401	1.31E-33
UCS	Kinase	USP16	MAPK8	0.841698238	6.56E-34
UCS	Kinase	USP16	HIPK1	0.841827006	6.28E-34
UCS	Kinase	USP16	DYRK1A	0.846188457	1.34E-34
UCS	Kinase	USP16	TRRAP	0.850160969	3.17E-35
UCS	Kinase	USP16	CDK8	0.874016964	2.01E-39
UCS	TF	USP16	SP2	0.800448322	1.92E-28
UCS	TF	USP16	ZNF675	0.801006859	1.65E-28
UCS	TF	USP16	ZNF518A	0.801032582	1.64E-28
UCS	TF	USP16	ZNF235	0.803104791	9.33E-29
UCS	TF	USP16	ZNF318	0.803163849	9.19E-29
UCS	TF	USP16	ELF2	0.804437274	6.48E-29
UCS	TF	USP16	GPBP1L1	0.804859838	5.77E-29
UCS	TF	USP16	ZFP91	0.805372169	5.01E-29
UCS	TF	USP16	ZNF146	0.806310985	3.86E-29
UCS	TF	USP16	ZNF254	0.806516293	3.65E-29
UCS	TF	USP16	AEBP2	0.807318974	2.92E-29
UCS	TF	USP16	HMG20A	0.808426744	2.14E-29
UCS	TF	USP16	ZBTB39	0.812506313	6.70E-30
UCS	TF	USP16	ZFP30	0.814443098	3.82E-30
UCS	TF	USP16	FOXJ3	0.814563209	3.69E-30
UCS	TF	USP16	ZNF800	0.816005017	2.42E-30
UCS	TF	USP16	ADNP	0.819971337	7.42E-31
UCS	TF	USP16	ZUFSP	0.82062064	6.10E-31
UCS	TF	USP16	CDC5L	0.823080952	2.88E-31
UCS	TF	USP16	ZNF227	0.824222724	2.02E-31
UCS	TF	USP16	ZNF184	0.825512167	1.36E-31
UCS	TF	USP16	TOPORS	0.828358942	5.53E-32
UCS	TF	USP16	CREBZF	0.829216545	4.21E-32
UCS	TF	USP16	ZNF680	0.830787981	2.54E-32
UCS	TF	USP16	ZFX	0.831182268	2.23E-32
UCS	TF	USP16	ZNF708	0.833089508	1.20E-32
UCS	TF	USP16	ZNF136	0.833168525	1.17E-32
UCS	TF	USP16	PRMT3	0.83727972	2.98E-33
UCS	TF	USP16	ZNF430	0.841974156	5.96E-34
UCS	TF	USP16	ZBTB1	0.843366766	3.66E-34
UCS	TF	USP16	ZNF28	0.845279461	1.86E-34
UCS	TF	USP16	ZBTB11	0.850133756	3.20E-35
UCS	TF	USP16	ZNF468	0.850482091	2.81E-35
UCS	TF	USP16	ZNF143	0.852282913	1.44E-35
UCS	TF	USP16	ZNF225	0.856110486	3.35E-36
UCS	TF	USP16	ZNF627	0.856440194	2.95E-36
UCS	TF	USP16	YY1	0.856564887	2.81E-36
UCS	TF	USP16	DR1	0.857261682	2.15E-36
UCS	TF	USP16	ZNF765	0.858392708	1.38E-36
UCS	TF	USP16	ZNF217	0.859135646	1.03E-36
UCS	TF	USP16	CREB1	0.85926021	9.81E-37
UCS	TF	USP16	RLF	0.873399477	2.65E-39
UCS	TF	USP16	NR2C2	0.873707688	2.31E-39
UCS	TF	USP16	ATF1	0.878570801	2.54E-40
UCS	TF	USP16	SP4	0.885569331	8.96E-42
UCS	TF	USP16	ZNF567	0.886080725	6.96E-42
UCS	TF	USP16	ZNF776	0.892500432	2.61E-43
UCS	TF	USP16	SP3	0.893593133	1.46E-43
UCS	TF	USP16	ELF1	0.909386359	1.54E-47
UCS	TSG	USP16	GGNBP2	0.802881205	9.92E-29
UCS	TSG	USP16	NUP98	0.810281726	1.27E-29
UCS	TSG	USP16	ATR	0.813641029	4.82E-30
UCS	TSG	USP16	HLTF	0.815021737	3.23E-30
UCS	TSG	USP16	BRCA2	0.816977131	1.81E-30
UCS	TSG	USP16	VHL	0.819939152	7.49E-31
UCS	TSG	USP16	KDM3A	0.820697279	5.96E-31
UCS	TSG	USP16	LIN9	0.827889219	6.42E-32
UCS	TSG	USP16	TOPORS	0.828358942	5.53E-32
UCS	TSG	USP16	INTS6	0.830491762	2.79E-32
UCS	TSG	USP16	TANK	0.833373043	1.09E-32
UCS	TSG	USP16	CCAR1	0.83632997	4.10E-33
UCS	TSG	USP16	SIRT1	0.842334271	5.26E-34
UCS	TSG	USP16	RANBP9	0.84877631	5.27E-35
UCS	TSG	USP16	EAF1	0.851709473	1.78E-35
UCS	TSG	USP16	SETD2	0.853695999	8.44E-36
UCS	TSG	USP16	RB1CC1	0.853752685	8.26E-36
UCS	TSG	USP16	ING3	0.85697607	2.40E-36
UCS	TSG	USP16	RB1	0.867532626	3.35E-38
UCS	TSG	USP16	NR2C2	0.873707688	2.31E-39
UCS	TSG	USP16	RBL2	0.880940045	8.39E-41
UCS	TSG	USP16	HACE1	0.882082036	4.88E-41
UVM	Cell metabolism gene	USP16	ALG10B	0.800384153	5.19E-19
UVM	Cell metabolism gene	USP16	GALNT1	0.800612674	4.99E-19
UVM	Cell metabolism gene	USP16	SMG1	0.801966285	3.93E-19
UVM	Cell metabolism gene	USP16	LPGAT1	0.802296935	3.71E-19
UVM	Cell metabolism gene	USP16	ALG13	0.804267645	2.61E-19
UVM	Cell metabolism gene	USP16	PMPCB	0.80443426	2.53E-19
UVM	Cell metabolism gene	USP16	NUP50	0.806282968	1.82E-19
UVM	Cell metabolism gene	USP16	PIKFYVE	0.806455874	1.76E-19
UVM	Cell metabolism gene	USP16	NUP107	0.807537106	1.45E-19
UVM	Cell metabolism gene	USP16	FBXW7	0.808397271	1.24E-19
UVM	Cell metabolism gene	USP16	GPCPD1	0.809921497	9.34E-20
UVM	Cell metabolism gene	USP16	MTR	0.812173567	6.14E-20
UVM	Cell metabolism gene	USP16	AGL	0.812513522	5.76E-20
UVM	Cell metabolism gene	USP16	POLR3G	0.813517572	4.77E-20
UVM	Cell metabolism gene	USP16	DBT	0.814033837	4.33E-20
UVM	Cell metabolism gene	USP16	SRP19	0.814231065	4.17E-20
UVM	Cell metabolism gene	USP16	NUDT12	0.81473338	3.79E-20
UVM	Cell metabolism gene	USP16	ACSL4	0.815672923	3.17E-20
UVM	Cell metabolism gene	USP16	DCK	0.818777205	1.74E-20
UVM	Cell metabolism gene	USP16	NUPL1	0.822129347	8.99E-21
UVM	Cell metabolism gene	USP16	PPP1CB	0.823441875	6.91E-21
UVM	Cell metabolism gene	USP16	POLR3F	0.823542294	6.78E-21
UVM	Cell metabolism gene	USP16	COL4A3BP	0.825214157	4.84E-21
UVM	Cell metabolism gene	USP16	TBL1XR1	0.828153398	2.65E-21
UVM	Cell metabolism gene	USP16	CSGALNACT2	0.828636188	2.40E-21
UVM	Cell metabolism gene	USP16	GRPEL2	0.82882983	2.30E-21
UVM	Cell metabolism gene	USP16	DIS3	0.829673933	1.93E-21
UVM	Cell metabolism gene	USP16	IDI1	0.830132909	1.75E-21
UVM	Cell metabolism gene	USP16	PLA2G12A	0.833934461	7.83E-22
UVM	Cell metabolism gene	USP16	MTMR6	0.83469038	6.66E-22
UVM	Cell metabolism gene	USP16	RANBP2	0.835110962	6.08E-22
UVM	Cell metabolism gene	USP16	MED17	0.837171329	3.88E-22
UVM	Cell metabolism gene	USP16	ENOPH1	0.841158265	1.60E-22
UVM	Cell metabolism gene	USP16	AGPS	0.842653512	1.14E-22
UVM	Cell metabolism gene	USP16	PIK3CA	0.84350243	9.38E-23
UVM	Cell metabolism gene	USP16	PSMC6	0.84412379	8.13E-23
UVM	Cell metabolism gene	USP16	GNPDA2	0.846269203	4.94E-23
UVM	Cell metabolism gene	USP16	NUP54	0.852015492	1.25E-23
UVM	Cell metabolism gene	USP16	GXYLT1	0.853074066	9.69E-24
UVM	Cell metabolism gene	USP16	TRDMT1	0.855761814	4.97E-24
UVM	Cell metabolism gene	USP16	EDEM3	0.855822078	4.90E-24
UVM	Cell metabolism gene	USP16	PRKAA1	0.856593315	4.04E-24
UVM	Cell metabolism gene	USP16	UGGT2	0.857452198	3.25E-24
UVM	Cell metabolism gene	USP16	MANEA	0.859166282	2.10E-24
UVM	Cell metabolism gene	USP16	AASDHPPT	0.860672707	1.42E-24
UVM	Cell metabolism gene	USP16	C1GALT1	0.861313929	1.20E-24
UVM	Cell metabolism gene	USP16	TRMT11	0.865604145	3.84E-25
UVM	Cell metabolism gene	USP16	NUPL2	0.870371307	1.03E-25
UVM	Cell metabolism gene	USP16	NAMPT	0.872139537	6.25E-26
UVM	Cell metabolism gene	USP16	SACM1L	0.8805205	5.24E-27
UVM	Cell metabolism gene	USP16	FBXL3	0.889796005	2.69E-28
UVM	Cell metabolism gene	USP16	PNPLA8	0.892612189	1.04E-28
UVM	Cell metabolism gene	USP16	ETNK1	0.892861495	9.50E-29
UVM	Cell metabolism gene	USP16	FAR1	0.892913091	9.34E-29
UVM	CGC	USP16	STAG1	0.800241821	5.32E-19
UVM	CGC	USP16	ATRX	0.800598166	5.00E-19
UVM	CGC	USP16	APC	0.801035569	4.63E-19
UVM	CGC	USP16	TRIP11	0.802504746	3.57E-19
UVM	CGC	USP16	MAP3K1	0.802774243	3.41E-19
UVM	CGC	USP16	TRIM33	0.804643231	2.44E-19
UVM	CGC	USP16	ACVR2A	0.804749734	2.39E-19
UVM	CGC	USP16	MLLT10	0.806067137	1.89E-19
UVM	CGC	USP16	GOLGA5	0.8076809	1.41E-19
UVM	CGC	USP16	FBXW7	0.808397271	1.24E-19
UVM	CGC	USP16	HSP90AA1	0.81215495	6.16E-20
UVM	CGC	USP16	USP8	0.818861991	1.71E-20
UVM	CGC	USP16	DEK	0.825253041	4.80E-21
UVM	CGC	USP16	CDC73	0.828107443	2.67E-21
UVM	CGC	USP16	TBL1XR1	0.828153398	2.65E-21
UVM	CGC	USP16	PALB2	0.829087767	2.18E-21
UVM	CGC	USP16	CREB1	0.829758056	1.90E-21
UVM	CGC	USP16	ERCC4	0.831565898	1.30E-21
UVM	CGC	USP16	RAD17	0.833643863	8.34E-22
UVM	CGC	USP16	RANBP2	0.835110962	6.08E-22
UVM	CGC	USP16	RGPD3	0.838880831	2.66E-22
UVM	CGC	USP16	DDX10	0.840426971	1.88E-22
UVM	CGC	USP16	KIF5B	0.841499679	1.48E-22
UVM	CGC	USP16	BCLAF1	0.841977612	1.33E-22
UVM	CGC	USP16	RB1	0.842069557	1.30E-22
UVM	CGC	USP16	PIK3CA	0.84350243	9.38E-23
UVM	CGC	USP16	DDX5	0.845115262	6.47E-23
UVM	CGC	USP16	KTN1	0.853782915	8.14E-24
UVM	CGC	USP16	PHF6	0.854344607	7.08E-24
UVM	CGC	USP16	SUZ12	0.854352494	7.07E-24
UVM	CGC	USP16	DICER1	0.854637004	6.58E-24
UVM	CGC	USP16	GOPC	0.85848047	2.50E-24
UVM	CGC	USP16	SF3B1	0.863271377	7.17E-25
UVM	CGC	USP16	ARHGAP5	0.863467774	6.81E-25
UVM	CGC	USP16	STAG2	0.867781022	2.12E-25
UVM	CGC	USP16	PMS1	0.870880774	8.94E-26
UVM	CGC	USP16	MALT1	0.876133837	1.96E-26
UVM	CGC	USP16	ATR	0.876684987	1.67E-26
UVM	CGC	USP16	ETNK1	0.892861495	9.50E-29
UVM	Epifactor	USP16	ATRX	0.800598166	5.00E-19
UVM	Epifactor	USP16	UBE2B	0.80170861	4.11E-19
UVM	Epifactor	USP16	TRIM33	0.804643231	2.44E-19
UVM	Epifactor	USP16	MLLT10	0.806067137	1.89E-19
UVM	Epifactor	USP16	ZRANB3	0.806420251	1.77E-19
UVM	Epifactor	USP16	SUV420H1	0.809358975	1.04E-19
UVM	Epifactor	USP16	ATAD2B	0.810167745	8.92E-20
UVM	Epifactor	USP16	RSF1	0.810258071	8.78E-20
UVM	Epifactor	USP16	UBE2D1	0.81108358	7.53E-20
UVM	Epifactor	USP16	ANKRD32	0.811491814	6.98E-20
UVM	Epifactor	USP16	TAF7	0.811570931	6.88E-20
UVM	Epifactor	USP16	MPHOSPH8	0.813795626	4.53E-20
UVM	Epifactor	USP16	MAP3K7	0.814342215	4.08E-20
UVM	Epifactor	USP16	RCOR3	0.81547886	3.29E-20
UVM	Epifactor	USP16	YY1	0.816457848	2.73E-20
UVM	Epifactor	USP16	ING3	0.816784276	2.56E-20
UVM	Epifactor	USP16	NSL1	0.817779661	2.11E-20
UVM	Epifactor	USP16	TAF9B	0.818961472	1.68E-20
UVM	Epifactor	USP16	UHRF2	0.819797397	1.42E-20
UVM	Epifactor	USP16	HMGB1	0.820320114	1.29E-20
UVM	Epifactor	USP16	DNAJC2	0.820863228	1.16E-20
UVM	Epifactor	USP16	CHUK	0.823056166	7.47E-21
UVM	Epifactor	USP16	PHF14	0.823469017	6.88E-21
UVM	Epifactor	USP16	CHD9	0.824195831	5.94E-21
UVM	Epifactor	USP16	RLIM	0.824703197	5.36E-21
UVM	Epifactor	USP16	FAM175B	0.824799639	5.26E-21
UVM	Epifactor	USP16	DEK	0.825253041	4.80E-21
UVM	Epifactor	USP16	CIR1	0.826814605	3.49E-21
UVM	Epifactor	USP16	HCFC2	0.828034196	2.71E-21
UVM	Epifactor	USP16	CDC73	0.828107443	2.67E-21
UVM	Epifactor	USP16	TBL1XR1	0.828153398	2.65E-21
UVM	Epifactor	USP16	INO80D	0.831286658	1.38E-21
UVM	Epifactor	USP16	MBIP	0.83327174	9.03E-22
UVM	Epifactor	USP16	SMEK2	0.834683205	6.67E-22
UVM	Epifactor	USP16	PCGF6	0.834819923	6.47E-22
UVM	Epifactor	USP16	EPC2	0.836342384	4.65E-22
UVM	Epifactor	USP16	MBTD1	0.83651608	4.48E-22
UVM	Epifactor	USP16	USP15	0.837989585	3.24E-22
UVM	Epifactor	USP16	HLTF	0.838011994	3.22E-22
UVM	Epifactor	USP16	OGT	0.840973883	1.67E-22
UVM	Epifactor	USP16	RB1	0.842069557	1.30E-22
UVM	Epifactor	USP16	TLK1	0.842584622	1.16E-22
UVM	Epifactor	USP16	PHC3	0.845571608	5.82E-23
UVM	Epifactor	USP16	BRCC3	0.848679328	2.80E-23
UVM	Epifactor	USP16	ZMYND11	0.848782425	2.73E-23
UVM	Epifactor	USP16	CUL4B	0.84940163	2.36E-23
UVM	Epifactor	USP16	NIPBL	0.850960959	1.62E-23
UVM	Epifactor	USP16	RMI1	0.852399074	1.14E-23
UVM	Epifactor	USP16	SUZ12	0.854352494	7.07E-24
UVM	Epifactor	USP16	BAZ2B	0.854959834	6.08E-24
UVM	Epifactor	USP16	JMJD1C	0.855430523	5.40E-24
UVM	Epifactor	USP16	SMEK1	0.855450235	5.38E-24
UVM	Epifactor	USP16	PRKAA1	0.856593315	4.04E-24
UVM	Epifactor	USP16	ARID4B	0.862543948	8.70E-25
UVM	Epifactor	USP16	SF3B1	0.863271377	7.17E-25
UVM	Epifactor	USP16	CHD1	0.867888724	2.06E-25
UVM	Epifactor	USP16	ARID4A	0.868459809	1.76E-25
UVM	Epifactor	USP16	DNTTIP2	0.869924536	1.17E-25
UVM	Epifactor	USP16	PHIP	0.875860291	2.13E-26
UVM	Epifactor	USP16	ATR	0.876684987	1.67E-26
UVM	Epifactor	USP16	BRWD1	0.880277179	5.65E-27
UVM	Epifactor	USP16	CUL5	0.882983565	2.44E-27
UVM	Epifactor	USP16	YEATS4	0.890709786	1.98E-28
UVM	Epifactor	USP16	CUL2	0.890951838	1.82E-28
UVM	IUPHAR	USP16	PKN2	0.80073887	4.88E-19
UVM	IUPHAR	USP16	SLC30A5	0.801162476	4.53E-19
UVM	IUPHAR	USP16	SMG1	0.801966285	3.93E-19
UVM	IUPHAR	USP16	MAP3K1	0.802774243	3.41E-19
UVM	IUPHAR	USP16	NAPEPLD	0.802863753	3.35E-19
UVM	IUPHAR	USP16	TRIM33	0.804643231	2.44E-19
UVM	IUPHAR	USP16	ACVR2A	0.804749734	2.39E-19
UVM	IUPHAR	USP16	STK17A	0.8055177	2.09E-19
UVM	IUPHAR	USP16	PIKFYVE	0.806455874	1.76E-19
UVM	IUPHAR	USP16	VRK2	0.808526675	1.21E-19
UVM	IUPHAR	USP16	ATAD2B	0.810167745	8.92E-20
UVM	IUPHAR	USP16	HSP90AA1	0.81215495	6.16E-20
UVM	IUPHAR	USP16	MTR	0.812173567	6.14E-20
UVM	IUPHAR	USP16	SLC4A7	0.814209838	4.19E-20
UVM	IUPHAR	USP16	MAP3K7	0.814342215	4.08E-20
UVM	IUPHAR	USP16	SLC35A3	0.817511847	2.22E-20
UVM	IUPHAR	USP16	TNKS2	0.817980927	2.03E-20
UVM	IUPHAR	USP16	TBK1	0.818036822	2.01E-20
UVM	IUPHAR	USP16	ABCA5	0.818822359	1.72E-20
UVM	IUPHAR	USP16	RYK	0.819275545	1.58E-20
UVM	IUPHAR	USP16	SCYL2	0.821224794	1.08E-20
UVM	IUPHAR	USP16	CHUK	0.823056166	7.47E-21
UVM	IUPHAR	USP16	SLK	0.826388174	3.81E-21
UVM	IUPHAR	USP16	NR3C1	0.827462289	3.05E-21
UVM	IUPHAR	USP16	MAP3K2	0.827747568	2.88E-21
UVM	IUPHAR	USP16	IDI1	0.830132909	1.75E-21
UVM	IUPHAR	USP16	PLA2G12A	0.833934461	7.83E-22
UVM	IUPHAR	USP16	XIAP	0.834160545	7.46E-22
UVM	IUPHAR	USP16	NR2C1	0.834407123	7.08E-22
UVM	IUPHAR	USP16	NEK7	0.837228702	3.83E-22
UVM	IUPHAR	USP16	CLK1	0.837505468	3.60E-22
UVM	IUPHAR	USP16	STK38L	0.839641784	2.25E-22
UVM	IUPHAR	USP16	PRPF4B	0.841473242	1.49E-22
UVM	IUPHAR	USP16	TLK1	0.842584622	1.16E-22
UVM	IUPHAR	USP16	PIK3CA	0.84350243	9.38E-23
UVM	IUPHAR	USP16	SLC25A36	0.844072389	8.23E-23
UVM	IUPHAR	USP16	YES1	0.845346847	6.13E-23
UVM	IUPHAR	USP16	ATP11B	0.845357446	6.11E-23
UVM	IUPHAR	USP16	NEK1	0.845529098	5.87E-23
UVM	IUPHAR	USP16	SLC25A46	0.846812717	4.35E-23
UVM	IUPHAR	USP16	ZMYND11	0.848782425	2.73E-23
UVM	IUPHAR	USP16	MFN1	0.849477276	2.32E-23
UVM	IUPHAR	USP16	CRBN	0.852781561	1.04E-23
UVM	IUPHAR	USP16	IRAK4	0.853410937	8.92E-24
UVM	IUPHAR	USP16	TRPM7	0.853595457	8.52E-24
UVM	IUPHAR	USP16	BAZ2B	0.854959834	6.08E-24
UVM	IUPHAR	USP16	JMJD1C	0.855430523	5.40E-24
UVM	IUPHAR	USP16	PRKAA1	0.856593315	4.04E-24
UVM	IUPHAR	USP16	RIOK3	0.858707882	2.36E-24
UVM	IUPHAR	USP16	CLK4	0.858826247	2.29E-24
UVM	IUPHAR	USP16	CYP2R1	0.863306631	7.11E-25
UVM	IUPHAR	USP16	DYRK1A	0.865986887	3.46E-25
UVM	IUPHAR	USP16	SENP6	0.869499075	1.32E-25
UVM	IUPHAR	USP16	SENP7	0.875685674	2.24E-26
UVM	IUPHAR	USP16	PHIP	0.875860291	2.13E-26
UVM	IUPHAR	USP16	MALT1	0.876133837	1.96E-26
UVM	IUPHAR	USP16	ATR	0.876684987	1.67E-26
UVM	IUPHAR	USP16	BRWD1	0.880277179	5.65E-27
UVM	IUPHAR	USP16	BIRC2	0.894161107	6.06E-29
UVM	IUPHAR	USP16	CSNK1G3	0.901816529	3.76E-30
UVM	Kinase	USP16	PKN2	0.80073887	4.88E-19
UVM	Kinase	USP16	SMG1	0.801966285	3.93E-19
UVM	Kinase	USP16	MAP3K1	0.802774243	3.41E-19
UVM	Kinase	USP16	TRIM33	0.804643231	2.44E-19
UVM	Kinase	USP16	ACVR2A	0.804749734	2.39E-19
UVM	Kinase	USP16	STK17A	0.8055177	2.09E-19
UVM	Kinase	USP16	VRK2	0.808526675	1.21E-19
UVM	Kinase	USP16	MAP3K7	0.814342215	4.08E-20
UVM	Kinase	USP16	TBK1	0.818036822	2.01E-20
UVM	Kinase	USP16	RYK	0.819275545	1.58E-20
UVM	Kinase	USP16	SCYL2	0.821224794	1.08E-20
UVM	Kinase	USP16	CHUK	0.823056166	7.47E-21
UVM	Kinase	USP16	COL4A3BP	0.825214157	4.84E-21
UVM	Kinase	USP16	SLK	0.826388174	3.81E-21
UVM	Kinase	USP16	MAP3K2	0.827747568	2.88E-21
UVM	Kinase	USP16	NEK7	0.837228702	3.83E-22
UVM	Kinase	USP16	CLK1	0.837505468	3.60E-22
UVM	Kinase	USP16	STK38L	0.839641784	2.25E-22
UVM	Kinase	USP16	PRPF4B	0.841473242	1.49E-22
UVM	Kinase	USP16	TLK1	0.842584622	1.16E-22
UVM	Kinase	USP16	PAN3	0.842732509	1.12E-22
UVM	Kinase	USP16	YES1	0.845346847	6.13E-23
UVM	Kinase	USP16	NEK1	0.845529098	5.87E-23
UVM	Kinase	USP16	IRAK4	0.853410937	8.92E-24
UVM	Kinase	USP16	TRPM7	0.853595457	8.52E-24
UVM	Kinase	USP16	PRKAA1	0.856593315	4.04E-24
UVM	Kinase	USP16	RIOK3	0.858707882	2.36E-24
UVM	Kinase	USP16	CLK4	0.858826247	2.29E-24
UVM	Kinase	USP16	DYRK1A	0.865986887	3.46E-25
UVM	Kinase	USP16	ATR	0.876684987	1.67E-26
UVM	Kinase	USP16	CSNK1G3	0.901816529	3.76E-30
UVM	TF	USP16	ZNF564	0.800226648	5.33E-19
UVM	TF	USP16	ZNF484	0.80236933	3.66E-19
UVM	TF	USP16	ZNF253	0.804081413	2.70E-19
UVM	TF	USP16	ZMAT1	0.804875714	2.34E-19
UVM	TF	USP16	ZNF326	0.805114658	2.24E-19
UVM	TF	USP16	ZNF613	0.805741161	2.00E-19
UVM	TF	USP16	ZNF614	0.80579551	1.98E-19
UVM	TF	USP16	ZNF439	0.806993656	1.60E-19
UVM	TF	USP16	ZNF420	0.807394928	1.48E-19
UVM	TF	USP16	ZNF570	0.808120898	1.30E-19
UVM	TF	USP16	ZNF443	0.808498277	1.21E-19
UVM	TF	USP16	ZNF525	0.808696287	1.17E-19
UVM	TF	USP16	ZNF17	0.808727203	1.16E-19
UVM	TF	USP16	ZNF639	0.809928159	9.33E-20
UVM	TF	USP16	ZNF345	0.810618002	8.21E-20
UVM	TF	USP16	ZNF627	0.811588028	6.85E-20
UVM	TF	USP16	ZNF808	0.81241941	5.87E-20
UVM	TF	USP16	ZNF615	0.814185467	4.20E-20
UVM	TF	USP16	ZNF468	0.814872263	3.69E-20
UVM	TF	USP16	IKZF5	0.815038802	3.58E-20
UVM	TF	USP16	ZNF680	0.816183413	2.87E-20
UVM	TF	USP16	YY1	0.816457848	2.73E-20
UVM	TF	USP16	ZNF280C	0.817959728	2.04E-20
UVM	TF	USP16	BACH1	0.818049868	2.00E-20
UVM	TF	USP16	ZNF780A	0.818503635	1.83E-20
UVM	TF	USP16	ZNF235	0.818727825	1.76E-20
UVM	TF	USP16	ZNF24	0.819573656	1.49E-20
UVM	TF	USP16	PURB	0.820271651	1.30E-20
UVM	TF	USP16	MEF2A	0.82127378	1.07E-20
UVM	TF	USP16	ZNF655	0.821676797	9.83E-21
UVM	TF	USP16	ZNF480	0.822235702	8.80E-21
UVM	TF	USP16	ZNF84	0.822283638	8.72E-21
UVM	TF	USP16	ZNF184	0.822391593	8.53E-21
UVM	TF	USP16	ZNF227	0.822529282	8.30E-21
UVM	TF	USP16	SKIL	0.823629489	6.66E-21
UVM	TF	USP16	ZNF658	0.823781317	6.46E-21
UVM	TF	USP16	ZNF75D	0.824260236	5.86E-21
UVM	TF	USP16	ZNF765	0.824756986	5.30E-21
UVM	TF	USP16	THAP1	0.82492895	5.12E-21
UVM	TF	USP16	FOXN2	0.825566919	4.50E-21
UVM	TF	USP16	ZNF383	0.826531027	3.70E-21
UVM	TF	USP16	ZNF449	0.826585563	3.66E-21
UVM	TF	USP16	NR3C1	0.827462289	3.05E-21
UVM	TF	USP16	ZNF91	0.828039809	2.71E-21
UVM	TF	USP16	ZNF41	0.828210147	2.62E-21
UVM	TF	USP16	CREB1	0.829758056	1.90E-21
UVM	TF	USP16	ZNF507	0.830098472	1.77E-21
UVM	TF	USP16	ZNF277	0.830596049	1.59E-21
UVM	TF	USP16	ZNF675	0.831003652	1.46E-21
UVM	TF	USP16	ZNF224	0.831475314	1.32E-21
UVM	TF	USP16	ZNF585A	0.831511467	1.31E-21
UVM	TF	USP16	ZNF430	0.831612263	1.28E-21
UVM	TF	USP16	ELF2	0.832165379	1.14E-21
UVM	TF	USP16	HDX	0.832796855	9.99E-22
UVM	TF	USP16	ZNF12	0.833725634	8.19E-22
UVM	TF	USP16	ZNF260	0.833810021	8.04E-22
UVM	TF	USP16	ZNF44	0.834022156	7.69E-22
UVM	TF	USP16	NR2C1	0.834407123	7.08E-22
UVM	TF	USP16	RBAK	0.83458519	6.81E-22
UVM	TF	USP16	LIN54	0.834694985	6.65E-22
UVM	TF	USP16	ZNF143	0.834747674	6.57E-22
UVM	TF	USP16	PCGF6	0.834819923	6.47E-22
UVM	TF	USP16	ZNF461	0.834823025	6.47E-22
UVM	TF	USP16	ZNF347	0.835521021	5.56E-22
UVM	TF	USP16	ZUFSP	0.835945421	5.07E-22
UVM	TF	USP16	EEA1	0.836812694	4.20E-22
UVM	TF	USP16	ZNF558	0.837013374	4.02E-22
UVM	TF	USP16	ZNF566	0.837401868	3.69E-22
UVM	TF	USP16	ZNF510	0.837714906	3.44E-22
UVM	TF	USP16	ZNF354A	0.837957268	3.26E-22
UVM	TF	USP16	ZNF43	0.837968858	3.25E-22
UVM	TF	USP16	JRKL	0.838292074	3.03E-22
UVM	TF	USP16	ZNF674	0.838374985	2.98E-22
UVM	TF	USP16	ZNF800	0.838538873	2.87E-22
UVM	TF	USP16	ZNF141	0.840007066	2.07E-22
UVM	TF	USP16	ZNF791	0.8410409	1.64E-22
UVM	TF	USP16	SP3	0.841137478	1.61E-22
UVM	TF	USP16	ZNF25	0.841190417	1.59E-22
UVM	TF	USP16	ZNF721	0.84139871	1.51E-22
UVM	TF	USP16	ZFX	0.842147106	1.28E-22
UVM	TF	USP16	ZNF611	0.843398364	9.60E-23
UVM	TF	USP16	ZNF470	0.843462207	9.47E-23
UVM	TF	USP16	ZNF226	0.843665772	9.03E-23
UVM	TF	USP16	ZNF182	0.845309181	6.18E-23
UVM	TF	USP16	ZNF23	0.846995004	4.17E-23
UVM	TF	USP16	ZFP14	0.847390789	3.80E-23
UVM	TF	USP16	ZNF37A	0.847416128	3.78E-23
UVM	TF	USP16	NFXL1	0.847985682	3.30E-23
UVM	TF	USP16	ZNF248	0.848024276	3.27E-23
UVM	TF	USP16	ZNF782	0.848441297	2.96E-23
UVM	TF	USP16	ZNF493	0.848866576	2.68E-23
UVM	TF	USP16	ZNF131	0.84897985	2.61E-23
UVM	TF	USP16	CEBPZ	0.849743634	2.17E-23
UVM	TF	USP16	ZBTB41	0.850529443	1.80E-23
UVM	TF	USP16	ZNF140	0.852143051	1.22E-23
UVM	TF	USP16	ZNF254	0.852660803	1.07E-23
UVM	TF	USP16	ZNF181	0.853512133	8.70E-24
UVM	TF	USP16	ZNF320	0.85480909	6.31E-24
UVM	TF	USP16	BAZ2B	0.854959834	6.08E-24
UVM	TF	USP16	ZNF518A	0.855197327	5.73E-24
UVM	TF	USP16	ZNF33A	0.856718805	3.91E-24
UVM	TF	USP16	ZNF267	0.857106825	3.54E-24
UVM	TF	USP16	ZNF292	0.858262459	2.64E-24
UVM	TF	USP16	ZNF527	0.858692919	2.37E-24
UVM	TF	USP16	ZNF644	0.859583614	1.88E-24
UVM	TF	USP16	ZNF234	0.860030123	1.68E-24
UVM	TF	USP16	ZNF432	0.860357815	1.54E-24
UVM	TF	USP16	ZNF280D	0.861031328	1.29E-24
UVM	TF	USP16	MYNN	0.861506826	1.14E-24
UVM	TF	USP16	ZNF654	0.861873969	1.04E-24
UVM	TF	USP16	ZNF799	0.86189421	1.03E-24
UVM	TF	USP16	SMAD5	0.862683655	8.38E-25
UVM	TF	USP16	ZNF761	0.862848559	8.03E-25
UVM	TF	USP16	ZNF529	0.863514117	6.73E-25
UVM	TF	USP16	ZNF708	0.864590849	5.05E-25
UVM	TF	USP16	ZNF302	0.865111731	4.39E-25
UVM	TF	USP16	ZNF136	0.865172461	4.32E-25
UVM	TF	USP16	AHCTF1	0.865435536	4.02E-25
UVM	TF	USP16	ZNF845	0.866039526	3.41E-25
UVM	TF	USP16	ZNF14	0.866113516	3.35E-25
UVM	TF	USP16	ZNF138	0.866920535	2.69E-25
UVM	TF	USP16	ZNF440	0.867163102	2.51E-25
UVM	TF	USP16	CREBZF	0.867474754	2.31E-25
UVM	TF	USP16	ZNF780B	0.867770363	2.13E-25
UVM	TF	USP16	ZNF606	0.867986711	2.00E-25
UVM	TF	USP16	ZNF701	0.868162499	1.91E-25
UVM	TF	USP16	ZNF10	0.868530261	1.72E-25
UVM	TF	USP16	ZNF569	0.869076174	1.48E-25
UVM	TF	USP16	ZNF268	0.870798176	9.15E-26
UVM	TF	USP16	ZNF567	0.871205093	8.16E-26
UVM	TF	USP16	ZBTB1	0.871715067	7.06E-26
UVM	TF	USP16	ZNF83	0.872414488	5.78E-26
UVM	TF	USP16	THAP5	0.874109125	3.55E-26
UVM	TF	USP16	ZNF600	0.874345751	3.31E-26
UVM	TF	USP16	ZNF180	0.874648218	3.03E-26
UVM	TF	USP16	ZNF148	0.876844837	1.59E-26
UVM	TF	USP16	ZNF700	0.879340398	7.51E-27
UVM	TF	USP16	ZNF28	0.881825759	3.50E-27
UVM	TF	USP16	ZNF441	0.88289993	2.51E-27
UVM	TF	USP16	ZNF354B	0.886421586	8.16E-28
UVM	TF	USP16	GPBP1	0.887193962	6.35E-28
UVM	TF	USP16	ZNF160	0.890293738	2.28E-28
UVM	TF	USP16	THAP6	0.892408275	1.11E-28
UVM	TF	USP16	ZNF26	0.893134469	8.65E-29
UVM	TF	USP16	ZNF431	0.894337688	5.69E-29
UVM	TF	USP16	ZBTB11	0.894764301	4.90E-29
UVM	TF	USP16	DMTF1	0.896366876	2.78E-29
UVM	TF	USP16	ZBED5	0.899963154	7.52E-30
UVM	TF	USP16	THAP9	0.901303659	4.56E-30
UVM	TF	USP16	TMF1	0.905370324	9.57E-31
UVM	TF	USP16	ZNF195	0.910125887	1.40E-31
UVM	TF	USP16	GABPA	0.924245489	2.35E-34
UVM	TSG	USP16	APC	0.801035569	4.63E-19
UVM	TSG	USP16	NAPEPLD	0.802863753	3.35E-19
UVM	TSG	USP16	SMCHD1	0.803459565	3.02E-19
UVM	TSG	USP16	FBXW7	0.808397271	1.24E-19
UVM	TSG	USP16	RCHY1	0.809407725	1.03E-19
UVM	TSG	USP16	RINT1	0.809909463	9.36E-20
UVM	TSG	USP16	LXN	0.811942566	6.41E-20
UVM	TSG	USP16	MLH3	0.815306433	3.40E-20
UVM	TSG	USP16	TBRG1	0.815366021	3.36E-20
UVM	TSG	USP16	LIN9	0.815653517	3.18E-20
UVM	TSG	USP16	ING3	0.816784276	2.56E-20
UVM	TSG	USP16	UHRF2	0.819797397	1.42E-20
UVM	TSG	USP16	APAF1	0.821878861	9.45E-21
UVM	TSG	USP16	NEDD4	0.822956028	7.62E-21
UVM	TSG	USP16	CHUK	0.823056166	7.47E-21
UVM	TSG	USP16	SKIL	0.823629489	6.66E-21
UVM	TSG	USP16	RB1CC1	0.824502788	5.58E-21
UVM	TSG	USP16	CDC73	0.828107443	2.67E-21
UVM	TSG	USP16	PALB2	0.829087767	2.18E-21
UVM	TSG	USP16	INTS6	0.831552091	1.30E-21
UVM	TSG	USP16	CCAR1	0.835717504	5.33E-22
UVM	TSG	USP16	HLTF	0.838011994	3.22E-22
UVM	TSG	USP16	RB1	0.842069557	1.30E-22
UVM	TSG	USP16	PNN	0.84370905	8.94E-23
UVM	TSG	USP16	USP33	0.845375277	6.09E-23
UVM	TSG	USP16	PHC3	0.845571608	5.82E-23
UVM	TSG	USP16	RBBP8	0.846247489	4.97E-23
UVM	TSG	USP16	COPS2	0.84851648	2.91E-23
UVM	TSG	USP16	ZMYND11	0.848782425	2.73E-23
UVM	TSG	USP16	DCLRE1A	0.851597664	1.39E-23
UVM	TSG	USP16	PHF6	0.854344607	7.08E-24
UVM	TSG	USP16	SUZ12	0.854352494	7.07E-24
UVM	TSG	USP16	DICER1	0.854637004	6.58E-24
UVM	TSG	USP16	PRKAA1	0.856593315	4.04E-24
UVM	TSG	USP16	ZNF292	0.858262459	2.64E-24
UVM	TSG	USP16	GORAB	0.866184782	3.28E-25
UVM	TSG	USP16	CHD1	0.867888724	2.06E-25
UVM	TSG	USP16	VEZT	0.869686727	1.25E-25
UVM	TSG	USP16	FAM188A	0.872922434	5.00E-26
UVM	TSG	USP16	PPM1A	0.873480279	4.26E-26
UVM	TSG	USP16	ATR	0.876684987	1.67E-26
UVM	TSG	USP16	KRIT1	0.879981514	6.18E-27
UVM	TSG	USP16	CUL5	0.882983565	2.44E-27
UVM	TSG	USP16	TANK	0.888136943	4.66E-28
UVM	TSG	USP16	CUL2	0.890951838	1.82E-28
UVM	TSG	USP16	DMTF1	0.896366876	2.78E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	USP16	RPS27A	1.75396693785956	0.000187873840332031
BRCA	USP16	UBB	-1.05093436922286	0.000803254671509667
BLCA	USP16	UBC	-2.97103318406418	0.0016937255859375
KIRP	USP16	UBC	-2.2186083712878	0.00192895717918873
ESCA	USP16	HIST2H2AC	-1.62110049111115	0.0029296875
COAD	USP16	UBB	-2.86349446749931	0.00468936562538148
LUAD	USP16	HIST2H2AC	-1.41129908671665	0.00471395891927286
PRAD	USP16	UBC	1.38340454972911	0.00482349779780149
THCA	USP16	UBA52	-5.39674760936528	0.00553919070100212
KIRP	USP16	UBB	-1.42640166348926	0.00608485564589501
COAD	USP16	UBC	1.14829675978632	0.012952595949173
PRAD	USP16	MYSM1	1.49586902301873	0.0144768970112973
UCEC	USP16	HIST2H2AC	3.43870476609598	0.015625
BRCA	USP16	UBC	-4.44331707162822	0.0160227796839167
HNSC	USP16	UBA52	-2.34636656943672	0.0165749692632744
LIHC	USP16	HIST2H2AC	1.59947514068662	0.0232975016819403
COAD	USP16	USP21	-1.32058286308983	0.023610919713974
KICH	USP16	UBA52	-1.6563124167392	0.0236499309539795
BLCA	USP16	RPS27A	-1.04747470069188	0.0258216857910156
READ	USP16	CDK1	1.89004239599197	0.03125
PRAD	USP16	HERC2	1.33143914482137	0.0466062163324045
KIRC	USP16	UBA52	-1.94377459466327	1.39011934742714e-10
KICH	USP16	USP21	1.55772727097587	2.21133232116699e-05
BRCA	USP16	HIST2H2AC	-2.38650325960437	2.57757338179631e-13
LIHC	USP16	USP21	-1.12365589470945	2.90698422155078e-09
KICH	USP16	HIST2H2AC	3.68104478367757	5.38825988769531e-05
BRCA	USP16	RPS27A	-4.28512148200424	7.8788217967112e-14
LIHC	USP16	CDK1	-2.27509761133223	8.79719397863617e-10
THCA	USP16	HERC2	-6.41164927442803	9.10957289155119e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with USP16

UBC, DBT, HIST1H2BL, HERC2, CALM1, FBXO11, HIST4H4, PTOV1, UBD, hist1h3g, CSNK1D, TXNL1, IGF2BP3, EXOSC10, HIST2H2AC, HIST2H2AA3, CDK1, USP16, HIST1H2AB, HIST1H2BB, XPO1, RNF8, PLK1, ESR1, H2AFZ, ALPPL2, APOM, NEURL4, WDR54, SRPRB, TTK, h2afx, UBE3A, SUZ12, MYC, NR2C2, PLEKHA4, HSPD1, HIST1H1B, N, nsp2, LDLR, LRRC59, DNAJC2, RPS20, NAA40, G0S2, OSCP1, SOST, PPL, ZRANB1, JAK1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
USP16	chr21	30411367	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
USP16	chr21	30419651	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
USP16	LUAD	chr21	30415863	30415863	T	C	Silent	p.S433S	7
USP16	UCEC	chr21	30418995	30418995	G	A	Missense_Mutation	p.R455Q	6
USP16	BLCA	chr21	30426152	30426152	C	G	Silent		5
USP16	HNSC	chr21	30419482	30419482	C	A	Missense_Mutation	p.F617L	5
USP16	PRAD	chr21	30411465	30411465	A	G	Missense_Mutation	p.Q284R	4
USP16	BLCA	chr21	30426152	30426152	C	G	Silent	p.L741L	4
USP16	LIHC	chr21	30415885	30415885	A	-	Frame_Shift_Del	p.K442fs	4
USP16	UCEC	chr21	30421169	30421169	T	G	Missense_Mutation	p.F700C	3
USP16	UCEC	chr21	30409702	30409702	C	A	Missense_Mutation	p.P185H	3
USP16	UCEC	chr21	30419561	30419561	G	A	Missense_Mutation	p.E644K	3
USP16	HNSC	chr21	30419482	30419482	C	A	Missense_Mutation		3
USP16	UCS	chr21	30403021	30403021	A	C	Missense_Mutation	p.K56T	3
USP16	LUAD	chr21	30403014	30403014	G	T	Missense_Mutation	p.D54Y	3
USP16	PAAD	chr21	30419159	30419159	G	A	Missense_Mutation	p.V510I	3
USP16	STAD	chr21	30419571	30419571	G	A	Missense_Mutation	p.R647Q	3
USP16	UCEC	chr21	30411440	30411440	G	A	Missense_Mutation	p.V276M	3
USP16	STAD	chr21	30407165	30407165	G	A	Missense_Mutation	p.G83D	2
USP16	STAD	chr21	30419465	30419465	G	A	Missense_Mutation		2
USP16	UCEC	chr21	30421130	30421130	C	A	Missense_Mutation	p.S687Y	2
USP16	STAD	chr21	30414846	30414846	T	C	Silent	p.D392D	2
USP16	UCEC	chr21	30403007	30403007	T	C	Silent	p.C51	2
USP16	STAD	chr21	30411466	30411466	G	T	Missense_Mutation		2
USP16	UCEC	chr21	30421166	30421166	G	T	Missense_Mutation	p.R699I	2
USP16	STAD	chr21	30408598	30408598	C	T	Silent	p.Y117Y	2
USP16	UCEC	chr21	30403058	30403058	G	A	Silent	p.K68	2
USP16	STAD	chr21	30426231	30426231	G	A	Missense_Mutation		2
USP16	UCEC	chr21	30426135	30426135	G	T	Nonsense_Mutation	p.E736*	2
USP16	BLCA	chr21	30419060	30419060	G	C	Missense_Mutation	p.E477Q	2
USP16	LGG	chr21	30419419	30419419	T	C	Silent		2
USP16	ESCA	chr21	30410683	30410683	G	C	Missense_Mutation	p.E222Q	2
USP16	LIHC	chr21	30419571	30419571	G	T	Missense_Mutation	p.R647L	2
USP16	UCEC	chr21	30409667	30409667	G	T	Missense_Mutation	p.E173D	2
USP16	STAD	chr21	30419465	30419465	G	A	Missense_Mutation	p.D612N	2
USP16	UCEC	chr21	30426476	30426476	G	T	Missense_Mutation	p.A814S	2
USP16	ESCA	chr21	30426152	30426152	C	G	Silent	p.L741	2
USP16	UCEC	chr21	30411452	30411452	G	T	Nonsense_Mutation	p.E280*	2
USP16	BLCA	chr21	30426392	30426392	G	A	Missense_Mutation		2
USP16	HNSC	chr21	30414333	30414333	G	C	Splice_Site		2
USP16	STAD	chr21	30411466	30411466	G	T	Missense_Mutation	p.Q284H	2
USP16	ESCA	chr21	30411852	30411852	G	A	Missense_Mutation	p.R305H	2
USP16	UCEC	chr21	30414424	30414424	C	A	Missense_Mutation	p.T374N	2
USP16	STAD	chr21	30419304	30419304	A	G	Missense_Mutation	p.N558S	2
USP16	LIHC	chr21	30403054	30403054	A	-	Frame_Shift_Del	p.E67fs	2
USP16	UCEC	chr21	30415769	30415769	A	C	Missense_Mutation	p.K402T	2
USP16	PAAD	chr21	30419159	30419159	G	A	Missense_Mutation		2
USP16	STAD	chr21	30409707	30409707	A	G	Missense_Mutation	p.M187V	2
USP16	COAD	chr21	30407196	30407196	G	T	Missense_Mutation	p.K93N	2
USP16	LIHC	chr21	30419571	30419571	G	T	Missense_Mutation		2
USP16	LIHC	chr21	30410691	30410691	A	-	Frame_Shift_Del	p.L224fs	2
USP16	STAD	chr21	30409640	30409640	A	G	Silent	p.L164L	2
USP16	LIHC	chr21	30411352	30411352	A	G	Silent		2
USP16	UCEC	chr21	30419197	30419197	C	T	Silent	p.I522	2
USP16	THYM	chr21	30421175	30421175	A	T	Missense_Mutation	p.Q702L	2
USP16	LUAD	chr21	30411359	30411359	A	G	Missense_Mutation	p.I249V	2
USP16	STAD	chr21	30409707	30409707	A	G	Missense_Mutation		2
USP16	UCEC	chr21	30419372	30419372	T	G	Missense_Mutation	p.L581V	2
USP16	KIRC	chr21	30415852	30415852	G	T	Missense_Mutation	p.D430Y	2
USP16	STAD	chr21	30422460	30422460	A	C	Missense_Mutation	p.E718D	2
USP16	STAD	chr21	30419304	30419304	A	G	Missense_Mutation		2
USP16	UCEC	chr21	30419452	30419452	G	T	Missense_Mutation	p.E607D	2
USP16	COAD	chr21	30426459	30426459	A	C	Missense_Mutation	p.K807T	1
USP16	LIHC	chr21	30409756	30409756	A	G	Missense_Mutation		1
USP16	SKCM	chr21	30419289	30419289	C	T	Missense_Mutation	p.P553L	1
USP16	GBM	chr21	30419570	30419570	C	T	Nonsense_Mutation		1
USP16	LIHC	chr21	30419188	30419188	A	-	Frame_Shift_Del	p.A519fs	1
USP16	LUSC	chr21	30403061	30403061	T	C	Silent	p.P69P	1
USP16	BLCA	chr21	30414378	30414378	T	C	Missense_Mutation	p.F359L	1
USP16	LGG	chr21	30419419	30419419	T	C	Silent	p.N596N	1
USP16	COAD	chr21	30409677	30409677	A	G	Missense_Mutation	p.K176E	1
USP16	LIHC	chr21	30409652	30409652	T	C	Silent	p.S168S	1
USP16	PRAD	chr21	30415788	30415788	G	T	Silent	p.V408V	1
USP16	SKCM	chr21	30409701	30409701	C	T	Missense_Mutation	p.P185S	1
USP16	GBM	chr21	30409731	30409731	G	A	Missense_Mutation		1
USP16	LUSC	chr21	30402983	30402983	G	T	Silent	p.V43V	1
USP16	BLCA	chr21	30426392	30426392	G	A	Missense_Mutation	p.E786K	1
USP16	LGG	chr21	30426427	30426427	C	T	Silent	p.S797S	1
USP16	ESCA	chr21	30402977	30402977	G	T	Silent	p.V41	1
USP16	LIHC	chr21	30409650	30409650	A	G	Missense_Mutation	p.S168G	1
USP16	READ	chr21	30426503	30426503	C	A	Missense_Mutation	p.L822M	1
USP16	SKCM	chr21	30414797	30414797	C	T	Missense_Mutation	p.S376F	1
USP16	UCEC	chr21	30403007	30403007	T	C	Silent	p.C51C	1
USP16	LUSC	chr21	30419000	30419000	C	T	Nonsense_Mutation	p.Q457*	1
USP16	SARC	chr21	30411418	30411418	G	T	Missense_Mutation		1
USP16	STAD	chr21	30426231	30426231	G	A	Missense_Mutation	p.A768T	1
USP16	SKCM	chr21	30409706	30409706	C	T	Silent	p.P186P	1
USP16	BLCA	chr21	30419526	30419526	C	T	Missense_Mutation		1
USP16	HNSC	chr21	30403060	30403060	C	T	Missense_Mutation		1
USP16	LUSC	chr21	30402967	30402967	A	G	Missense_Mutation	p.K38R	1
USP16	LIHC	chr21	30426156	30426156	T	C	Missense_Mutation		1
USP16	LIHC	chr21	30411352	30411352	A	G	Silent	p.P246P	1
USP16	SARC	chr21	30409689	30409689	G	T	Missense_Mutation		1
USP16	STAD	chr21	30415748	30415748	G	C	Missense_Mutation	p.G395A	1
USP16	SKCM	chr21	30422476	30422476	C	T	Missense_Mutation	p.P724S	1
USP16	MESO	chr21	30419606	30419606	C	T	Missense_Mutation		1
USP16	UCS	chr21	30403021	30403021	A	C	Missense_Mutation		1
USP16	BLCA	chr21	30403041	30403041	G	C	Missense_Mutation	p.E63Q	1
USP16	LIHC	chr21	30415885	30415885	A	-	Frame_Shift_Del		1
USP16	LIHC	chr21	30408697	30408698	-	A	Splice_Site		1
USP16	SARC	chr21	30411399	30411399	G	T	Missense_Mutation	p.S262I	1
USP16	STAD	chr21	30426506	30426508	TAA	-	In_Frame_Del	p.*824del	1
USP16	LUAD	chr21	30421097	30421097	T	G	Missense_Mutation	p.V676G	1
USP16	SKCM	chr21	30412976	30412976	A	C	Missense_Mutation	p.K333T	1
USP16	BLCA	chr21	30419060	30419060	G	C	Missense_Mutation		1
USP16	HNSC	chr21	30426392	30426392	G	C	Missense_Mutation	p.E786Q	1
USP16	MESO	chr21	30419606	30419606	C	T	Missense_Mutation	p.R659W	1
USP16	BLCA	chr21	30419563	30419563	G	C	Missense_Mutation	p.E644D	1
USP16	LIHC	chr21	30419464	30419464	A	G	Silent		1
USP16	ESCA	chr21	30402977	30402977	G	T	Silent		1
USP16	SKCM	chr21	30409680	30409680	G	A	Missense_Mutation	p.E177K	1
USP16	TGCT	chr21	30408670	30408670	A	T	Missense_Mutation		1
USP16	LUAD	chr21	30400249	30400249	G	A	Silent	p.R5R	1
USP16	SKCM	chr21	30409680	30409680	G	A	Missense_Mutation	p.E178K	1
USP16	HNSC	chr21	30403060	30403060	C	T	Missense_Mutation	p.P69L	1
USP16	ESCA	chr21	30410683	30410683	G	C	Missense_Mutation		1
USP16	SKCM	chr21	30409701	30409701	C	T	Missense_Mutation	p.P184S	1
USP16	THYM	chr21	30421175	30421175	A	T	Missense_Mutation		1
USP16	SKCM	chr21	30400247	30400247	C	T	Missense_Mutation	p.R5W	1
USP16	BLCA	chr21	30407258	30407258	T	C	Missense_Mutation		1
USP16	PAAD	chr21	30419012	30419012	C	A	Missense_Mutation		1
USP16	COAD	chr21	30408670	30408670	A	T	Missense_Mutation	p.Q141H	1
USP16	ESCA	chr21	30402977	30402977	G	T	Silent	p.V41V	1
USP16	SKCM	chr21	30414797	30414797	C	T	Missense_Mutation	p.S375F	1
USP16	THYM	chr21	30419608	30419608	G	T	Silent		1
USP16	SKCM	chr21	30408635	30408635	C	T	Nonsense_Mutation	p.Q130*	1
USP16	BLCA	chr21	30403041	30403041	G	C	Missense_Mutation		1
USP16	KICH	chr21	30409627	30409627	A	G	Missense_Mutation	p.E160G	1
USP16	LIHC	chr21	30426159	30426159	T	C	Silent		1
USP16	COAD	chr21	30412971	30412971	T	G	Silent	p.T330T	1
USP16	GBM	chr21	30409731	30409731	G	A	Missense_Mutation	p.V195M	1
USP16	LIHC	chr21	30402959	30402959	T	-	Frame_Shift_Del	p.N35fs	1
USP16	SKCM	chr21	30419289	30419289	C	T	Missense_Mutation	p.P552L	1
USP16	BLCA	chr21	30419563	30419563	G	C	Missense_Mutation		1
USP16	COAD	chr21	30419553	30419553	C	T	Missense_Mutation	p.T640I	1
USP16	LIHC	chr21	30411447	30411447	C	A	Missense_Mutation		1
USP16	PCPG	chr21	30400238	30400238	G	A	Missense_Mutation		1
USP16	SKCM	chr21	30422476	30422476	C	T	Missense_Mutation	p.P723S	1
USP16	THYM	chr21	30421170	30421170	T	C	Silent	p.F700F	1
USP16	GBM	chr21	30400269	30400269	C	T	Missense_Mutation		1
USP16	LIHC	chr21	30407261	30407261	G	-	Splice_Site	p.W115_splice	1
USP16	LUAD	chr21	30407158	30407158	G	T	Splice_Site	p.G81_splice	1
USP16	BLCA	chr21	30419526	30419526	C	T	Missense_Mutation	p.S632L	1
USP16	LGG	chr21	30419419	30419419	T	C	Silent	p.N595N	1

Copy number variation (CNV) of USP16
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across USP16
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97248	SARC	TCGA-3B-A9HS-01A	USP16	chr21	30397098	+	ACSS3	chr12	81545623	+
103122	HNSC	TCGA-D6-6825-01A	USP16	chr21	30403094	+	CNBD2	chr20	34560551	+
97248	N/A	AA876576	USP16	chr21	30416912	-	N6AMT1	chr21	30079720	-
97248	N/A	FN154948	USP16	chr21	30415260	+	NKAIN2	chr6	124951882	-
97248	N/A	AI084599	USP16	chr21	30414376	-	PRDX1	chr1	45976942	+
101122	.	.	USP16	chr21	30408591	+	RUNX1	chr21	30408591	-
97248	BRCA	TCGA-B6-A0RH-01A	USP16	chr21	30414849	+	SCOC	chr4	141300723	+
97248	N/A	AI221835	USP16	chr21	30408665	-	USP16	chr21	30415906	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	USP16	0.000556002289055337	0.016
KIRP	USP16	0.00968783735110597	0.26
ESCA	USP16	0.0182538519973521	0.47

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	USP16	0.0230086206641211	0.76
LGG	USP16	0.031401315285669	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source