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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: IGF2BP2 (NCBI Gene ID:10644)

Gene Summary

Gene Summary

Gene Information	Gene Name: IGF2BP2
	Gene ID: 10644
	Gene Symbol	IGF2BP2
	Gene ID	10644
	Gene Name	insulin like growth factor 2 mRNA binding protein 2
	Synonyms	IMP-2\|IMP2\|VICKZ2
	Cytomap	3q27.2
	Type of Gene	protein-coding
	Description	insulin-like growth factor 2 mRNA-binding protein 2IGF-II mRNA-binding protein 2IGF2 mRNA-binding protein 2VICKZ family member 2
	Modification date	20200313
	UniProtAcc	Q9Y6M1

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
IGF2BP2	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'IGF2BP2[title] AND translation [title] AND human.'

Gene	Title	PMID
IGF2BP2	Long noncoding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2	32437062

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000346192	185367190	185367322	In-frame
ENST00000346192	185369881	185369956	In-frame
ENST00000346192	185407142	185407415	In-frame
ENST00000346192	185410486	185410550	Frame-shift
ENST00000346192	185414399	185414451	Frame-shift
ENST00000346192	185416086	185416135	Frame-shift
ENST00000346192	185540940	185541001	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000346192	185367190	185367322	3308	1397	1528	599	444	488
ENST00000346192	185369881	185369956	3308	1322	1396	599	419	444
ENST00000346192	185407142	185407415	3308	469	741	599	135	225

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9Y6M1	135	225	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
Q9Y6M1	419	444	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
Q9Y6M1	444	488	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
Q9Y6M1	135	225	82	157	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
Q9Y6M1	135	225	193	258	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00117
Q9Y6M1	419	444	427	492	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00117
Q9Y6M1	444	488	427	492	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00117
Q9Y6M1	135	225	162	162	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
Q9Y6M1	135	225	164	164	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
Q9Y6M1	135	225	211	211	Mutagenesis	Note=Significantly impaired binding to ACTB transcript%2C but little effect on MYC transcript binding%2C accumulation in the nucleus%3B when associated with E-292. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2%2C almost complete loss of ACTB and MYC transcript binding%2C almost complete loss of ELAVL1-%2C DHX9- and HNRNPU-binding and perturbed subcellular location%2C including accumulation in the nucleus and loss of localization to stress granules%3B when associated with E-292%3B 445-E-E-446 and 526-E-E-527. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23640942;Dbxref=PMID:23640942
Q9Y6M1	444	488	445	446	Mutagenesis	Note=Significantly impaired binding to ACTB and MYC transcripts%3B when associated with 527-E-E-528. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2%2C almost complete loss of ACTB and MYC transcript binding%2C almost complete loss of ELAVL1-%2C DHX9- and HNRNPU-binding and perturbed subcellular location%2C including accumulation in the nucleus and loss of localization to stress granules%3B when associated with E-211%3B E-292 and 527-E-E-528. KK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:23640942;Dbxref=PMID:23640942

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	IGF2BP2	-1.28251900150286	0.00251545393492315
ESCA	IGF2BP2	1.44682845104602	0.0068359375
THCA	IGF2BP2	2.42715375485149	1.38653386544158e-06
LUSC	IGF2BP2	2.77938194008141	3.28251669457867e-08
BRCA	IGF2BP2	2.4784987517047	5.24897986361232e-23

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
BRCA	IGF2BP2	hsa-miR-181a-5p	88	-0.3	0.00742911831864027
CHOL	IGF2BP2	hsa-miR-181c-5p	88	-0.348353096179183	0.0195081141860532
CHOL	IGF2BP2	hsa-miR-181d-5p	90	-0.377075098814229	0.0110987413372669
COAD	IGF2BP2	hsa-miR-181c-5p	88	0.314143135345667	0.00498152910912435
UCS	IGF2BP2	hsa-miR-181b-5p	88	0.331168831168831	0.0130103794744399

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
KIRC	IGF2BP2	2	1	0.0340897435795686	0.240860044771808	0.173702873563218	-0.386098641594831	-0.529317060288731

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	IGF2BP2	-0.019771817	0.029564229
KIRC	IGF2BP2	0.009054178	0.034656278
LUSC	IGF2BP2	0.049160625	0.044060465

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with IGF2BP2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Epifactor	IGF2BP2	PCGF2	0.811474152	1.37E-11
CHOL	TF	IGF2BP2	PCGF2	0.811474152	1.37E-11
CHOL	TSG	IGF2BP2	PCGF2	0.811474152	1.37E-11
THCA	CGC	IGF2BP2	HMGA2	0.802106241	9.99E-130
THCA	CGC	IGF2BP2	PLAG1	0.809976308	3.25E-134
THCA	TF	IGF2BP2	HMGA2	0.802106241	9.99E-130
THCA	TF	IGF2BP2	PLAG1	0.809976308	3.25E-134

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type

Translation factor

Interacting protein coding gene

adj.pval

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with IGF2BP2

PUF60, HNRNPA1, MEPCE, CDK9, MYC, ICT1, Mapk13, ELAVL1, ARRB1, SIRT7, CUL3, CAND1, HNRNPD, RAB5A, PPAP2A, PA2G4, FN1, ITGA4, CBX6, CBX8, TARDBP, SAV1, WWOX, EIF2AK2, STAU1, CCDC8, IGF2BP1, OFD1, CCP110, CNTRL, FBF1, DCTN1, MCM2, ZNF746, CDC14A, ELAVL2, RBM3, CYLD, TRIM25, G3BP1, CFTR, CLEC14A, PCBP1, TNIP2, CHD3, RNF4, LARP7, HEXIM1, RECQL4, FBL, KIAA1429, RC3H1, RC3H2, PHB, ZC3H7A, NR2C2, OASL, SNRNP70, DUSP14, ARAF, WWP2, BRD7, TRIM28, SOX2, CMTR1, PLEKHA4, PINK1, HCVgp1, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ZC3H18, DUSP1, GRB10, ATXN2, CELF1, CPEB4, CSDE1, DAZL, DDX3X, EIF4ENIF1, FAM120A, FAM120C, FMR1, FUBP3, HELZ, AGO1, AGO2, ALG13, ANKHD1, CELF2, DAP3, DDX1, DDX6, DHX57, G3BP2, GRSF1, GTPBP1, HNRNPA2B1, HNRNPA3, HNRNPAB, IGF2BP3, LARP4, LARP4B, LSM12, LSM14A, FAM195A, MEX3A, MKRN2, MOV10, MRPS22, MRPS23, MRPS26, MRPS27, MRPS31, MRPS34, MRPS35, MRPS5, MRPS7, MRPS9, NUPL2, OTUD4, PABPC1, PABPC4, PATL1, PCBP2, PRRC2A, PRRC2B, PRRC2C, PTBP1, PTBP3, PTCD3, R3HDM1, RAVER1, RBMS1, RBMS2, SECISBP2, SMG1, SMG7, STRAP, SYNCRIP, TDRD3, TNRC6B, TOP3B, UPF1, YTHDF1, YTHDF2, ZCCHC11, ZCCHC3, KIF1B, MEX3B, PUM1, R3HDM2, RBM47, TRIM56, UBAP2L, UNK, USP10, XRN1, YTHDF3, ZC3HAV1, ZFP36, CAPRIN1, MRPS2, PARP12, PUM2, STAU2, TIAL1, PRMT1, SAMD4B, TDRD7, LSM14B, FAM195B, GLE1, LARP1B, MRPL4, MRPS14, MRPS16, MRPS18B, SMG5, TROVE2, CIT, ANLN, ECT2, KIF14, KIF20A, KIF23, PRC1, BRD1, PHIP, C8orf82, METTL17, MTERF3, TRUB2, NDN, MAFB, RBM45, RBM39, N, MKRN1, IFI16, CIAO1, OGT, UFL1, DDRGK1, AKAP1, COX8A, LYN, RPS20, SERBP1, FZR1, WDR5, NAA40, PRR3, RALY, PURG, YBX2, HNRNPCL2, HNRNPUL2, GSPT2, HNRNPC, MAP7, SRSF3, PABPC5, PAIP1, APOBEC3D, BTF3, FBXW7, NLRP7, CLEC4D, nsp14, HECTD1, CPEB1, KLF4,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
IGF2BP2	chr3	185369900	T	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
IGF2BP2	chr3	185511687	G	T	single_nucleotide_variant	risk_factor	Diabetes_mellitus_type_2,_susceptibility_to	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
IGF2BP2	PAAD	chr3	185407235	185407235	C	T	Silent	p.P195P	5
IGF2BP2	SKCM	chr3	185407293	185407293	G	A	Missense_Mutation	p.S176F	4
IGF2BP2	PAAD	chr3	185364845	185364845	C	T	Missense_Mutation	p.V559I	4
IGF2BP2	LUAD	chr3	185390392	185390392	G	A	Silent	p.S379S	3
IGF2BP2	UCEC	chr3	185367217	185367217	G	A	Missense_Mutation	p.R523W	3
IGF2BP2	BLCA	chr3	185375096	185375096	C	T	Missense_Mutation		3
IGF2BP2	PAAD	chr3	185364845	185364845	C	T	Missense_Mutation		3
IGF2BP2	COAD	chr3	185390421	185390421	C	T	Missense_Mutation	p.A370T	3
IGF2BP2	LGG	chr3	185393095	185393095	G	A	Silent		3
IGF2BP2	BRCA	chr3	185367245	185367245	A	C	Missense_Mutation	p.H513Q	3
IGF2BP2	LIHC	chr3	185390353	185390353	G	-	Frame_Shift_Del	p.P392fs	3
IGF2BP2	HNSC	chr3	185363333	185363333	G	A	Nonsense_Mutation	p.Q596*	3
IGF2BP2	KIRP	chr3	185542743	185542743	C	G	Missense_Mutation	p.M2I	3
IGF2BP2	LUAD	chr3	185369906	185369906	G	A	Silent	p.T479T	2
IGF2BP2	STAD	chr3	185367313	185367313	G	A	Missense_Mutation	p.R491W	2
IGF2BP2	SKCM	chr3	185407273	185407273	G	A	Missense_Mutation	p.P183S	2
IGF2BP2	CHOL	chr3	185542734	185542734	A	C	Silent	p.L5L	2
IGF2BP2	STAD	chr3	185367233	185367233	G	T	Silent		2
IGF2BP2	STAD	chr3	185375140	185375140	G	A	Silent	p.G440G	2
IGF2BP2	SKCM	chr3	185407217	185407217	G	A	Silent	p.P201P	2
IGF2BP2	STAD	chr3	185407221	185407221	A	G	Missense_Mutation		2
IGF2BP2	LGG	chr3	185393095	185393095	G	A	Silent	p.L354L	2
IGF2BP2	SARC	chr3	185407144	185407144	G	A	Missense_Mutation		2
IGF2BP2	STAD	chr3	185404892	185404892	G	A	Silent	p.C255C	2
IGF2BP2	SKCM	chr3	185390337	185390337	G	A	Missense_Mutation	p.P398S	2
IGF2BP2	UCEC	chr3	185367192	185367192	G	T	Missense_Mutation	p.T531N	2
IGF2BP2	BLCA	chr3	185390367	185390367	G	A	Missense_Mutation	p.R388C	2
IGF2BP2	LUAD	chr3	185376161	185376161	G	A	Missense_Mutation	p.H413Y	2
IGF2BP2	STAD	chr3	185414441	185414441	C	G	Missense_Mutation		2
IGF2BP2	PAAD	chr3	185407235	185407235	C	T	Silent		2
IGF2BP2	STAD	chr3	185407313	185407313	G	T	Silent	p.A169A	2
IGF2BP2	LIHC	chr3	185363390	185363390	C	-	Frame_Shift_Del	p.E577fs	2
IGF2BP2	UCEC	chr3	185367281	185367281	G	T	Missense_Mutation	p.F501L	2
IGF2BP2	STAD	chr3	185407221	185407221	A	G	Missense_Mutation	p.V200A	2
IGF2BP2	SARC	chr3	185407306	185407306	C	T	Missense_Mutation		2
IGF2BP2	LIHC	chr3	185390344	185390344	G	-	Frame_Shift_Del	p.P395fs	2
IGF2BP2	SKCM	chr3	185364881	185364881	G	A	Missense_Mutation	p.R547C	2
IGF2BP2	UCEC	chr3	185369907	185369907	G	A	Missense_Mutation	p.T479I	2
IGF2BP2	LUAD	chr3	185390422	185390422	G	A	Silent	p.S369S	2
IGF2BP2	STAD	chr3	185414441	185414441	C	G	Missense_Mutation	p.G100A	2
IGF2BP2	BLCA	chr3	185375096	185375096	C	T	Missense_Mutation	p.R455K	2
IGF2BP2	LIHC	chr3	185410564	185410564	A	-	Frame_Shift_Del	p.F115fs	2
IGF2BP2	SKCM	chr3	185375161	185375161	G	A	Silent	p.F433F	2
IGF2BP2	UCEC	chr3	185376161	185376161	G	T	Missense_Mutation	p.H413N	2
IGF2BP2	STAD	chr3	185369933	185369933	G	A	Silent	p.D470D	2
IGF2BP2	LIHC	chr3	185393150	185393150	G	A	Silent		2
IGF2BP2	SARC	chr3	185407306	185407306	C	T	Missense_Mutation	p.G172R	2
IGF2BP2	UCEC	chr3	185393145	185393145	G	A	Missense_Mutation	p.A337V	2
IGF2BP2	STAD	chr3	185363326	185363326	C	T	Missense_Mutation	p.S598N	2
IGF2BP2	TGCT	chr3	185407330	185407330	A	T	Missense_Mutation		2
IGF2BP2	CESC	chr3	185407163	185407163	G	A	Silent		2
IGF2BP2	UCEC	chr3	185404935	185404935	G	T	Missense_Mutation	p.P241H	2
IGF2BP2	KIRC	chr3	185393190	185393190	T	A	Missense_Mutation	p.E322V	2
IGF2BP2	PRAD	chr3	185542687	185542687	T	C	Missense_Mutation	p.Q21R	2
IGF2BP2	LUAD	chr3	185363402	185363402	G	A	Missense_Mutation	p.R573C	2
IGF2BP2	UCEC	chr3	185407235	185407235	C	T	Silent	p.A140T	2
IGF2BP2	STAD	chr3	185393611	185393611	T	C	Silent	p.E301E	2
IGF2BP2	UCEC	chr3	185407367	185407367	C	A	Missense_Mutation	p.K151N	2
IGF2BP2	CHOL	chr3	185542734	185542734	A	C	Silent		1
IGF2BP2	SKCM	chr3	185393213	185393213	C	T	Silent	p.Q314Q	1
IGF2BP2	KIRP	chr3	185390356	185390356	G	T	Silent		1
IGF2BP2	LUSC	chr3	185407394	185407394	C	T	Silent	p.G142G	1
IGF2BP2	READ	chr3	185542705	185542705	G	T	Missense_Mutation	p.T15N	1
IGF2BP2	UCEC	chr3	185407275	185407275	G	T	Missense_Mutation	p.A182D	1
IGF2BP2	BLCA	chr3	185407370	185407370	G	A	Silent		1
IGF2BP2	LIHC	chr3	185410534	185410534	T	C	Silent	p.E119E	1
IGF2BP2	KIRP	chr3	185375143	185375143	C	A	Silent		1
IGF2BP2	MESO	chr3	185542727	185542727	C	A	Missense_Mutation		1
IGF2BP2	SARC	chr3	185540945	185540945	G	T	Missense_Mutation		1
IGF2BP2	LIHC	chr3	185390424	185390424	T	A	Missense_Mutation	p.S369C	1
IGF2BP2	COAD	chr3	185367249	185367249	G	A	Missense_Mutation	p.A512V	1
IGF2BP2	LUAD	chr3	185393094	185393094	A	G	Missense_Mutation	p.L354P	1
IGF2BP2	LIHC	chr3	185393150	185393150	G	A	Silent	p.A335A	1
IGF2BP2	LGG	chr3	185407364	185407364	A	G	Silent	p.I152I	1
IGF2BP2	SARC	chr3	185375118	185375118	C	T	Missense_Mutation		1
IGF2BP2	BLCA	chr3	185407296	185407296	G	A	Missense_Mutation	p.S175F	1
IGF2BP2	COAD	chr3	185407397	185407397	G	A	Silent	p.S141S	1
IGF2BP2	LUAD	chr3	185404921	185404921	C	T	Missense_Mutation	p.A246T	1
IGF2BP2	PAAD	chr3	185416122	185416122	G	T	Missense_Mutation		1
IGF2BP2	STAD	chr3	185367233	185367233	G	T	Silent	p.P517P	1
IGF2BP2	BLCA	chr3	185369897	185369897	C	T	Silent	p.P482P	1
IGF2BP2	DLBC	chr3	185542653	185542653	T	A	Silent	p.G32G	1
IGF2BP2	LGG	chr3	185407364	185407364	A	G	Silent		1
IGF2BP2	SARC	chr3	185410529	185410529	G	T	Missense_Mutation		1
IGF2BP2	STAD	chr3	185390359	185390359	A	T	Silent	p.A390A	1
IGF2BP2	ESCA	chr3	185367249	185367249	G	T	Missense_Mutation	p.A512E	1
IGF2BP2	LUAD	chr3	185367198	185367198	C	A	Missense_Mutation	p.G529V	1
IGF2BP2	STAD	chr3	185416116	185416116	G	A	Nonsense_Mutation	p.R87*	1
IGF2BP2	SKCM	chr3	185404916	185404916	G	A	Silent	p.T247T	1
IGF2BP2	LUAD	chr3	185364843	185364843	G	A	Silent	p.V559V	1
IGF2BP2	ACC	chr3	185407396	185407396	C	G	Missense_Mutation	p.G142R	1
IGF2BP2	LIHC	chr3	185375098	185375098	C	T	Silent		1
IGF2BP2	SARC	chr3	185407144	185407144	G	A	Splice_Site	p.R226_splice	1
IGF2BP2	LIHC	chr3	185367272	185367272	G	-	Frame_Shift_Del	p.P504fs	1
IGF2BP2	SKCM	chr3	185369896	185369896	C	T	Missense_Mutation	p.E483K	1
IGF2BP2	LUSC	chr3	185393116	185393116	C	T	Missense_Mutation	p.E347K	1
IGF2BP2	STAD	chr3	185407143	185407143	C	T	Missense_Mutation	p.R226Q	1
IGF2BP2	BLCA	chr3	185407260	185407260	G	C	Missense_Mutation		1
IGF2BP2	LIHC	chr3	185410534	185410534	T	C	Silent		1
IGF2BP2	SARC	chr3	185364833	185364833	C	A	Missense_Mutation	p.G563W	1
IGF2BP2	TGCT	chr3	185407330	185407330	A	T	Missense_Mutation	p.S164T	1
IGF2BP2	CESC	chr3	185393021	185393022	GC	-	RNA	NULL	1
IGF2BP2	SKCM	chr3	185364834	185364834	G	A	Silent	p.I562I	1
IGF2BP2	KIRP	chr3	185364916	185364916	A	G	Missense_Mutation	p.L535P	1
IGF2BP2	LUSC	chr3	185414409	185414409	C	T	Missense_Mutation	p.V111M	1
IGF2BP2	READ	chr3	185542654	185542654	C	T	Missense_Mutation	p.G32E	1
IGF2BP2	THCA	chr3	185407353	185407353	G	T	Missense_Mutation		1
IGF2BP2	BLCA	chr3	185390431	185390431	C	G	Missense_Mutation		1
IGF2BP2	LIHC	chr3	185407372	185407372	A	G	Missense_Mutation		1
IGF2BP2	SARC	chr3	185407144	185407144	G	A	Missense_Mutation	p.R226W	1
IGF2BP2	CESC	chr3	185407163	185407163	G	A	Silent	p.I219	1
IGF2BP2	LUAD	chr3	185404893	185404893	C	A	Missense_Mutation	p.C255F	1
IGF2BP2	SKCM	chr3	185404970	185404970	G	A	Silent	p.I229I	1
IGF2BP2	LUSC	chr3	185407290	185407290	C	T	Missense_Mutation	p.R177Q	1
IGF2BP2	READ	chr3	185542704	185542704	G	C	Silent	p.T15T	1
IGF2BP2	STAD	chr3	185416116	185416116	G	A	Nonsense_Mutation	p.R87X	1
IGF2BP2	SARC	chr3	185414435	185414435	A	-	Frame_Shift_Del	p.L102fs	1
IGF2BP2	THYM	chr3	185367228	185367228	G	T	Missense_Mutation		1
IGF2BP2	BLCA	chr3	185369897	185369897	C	T	Silent		1
IGF2BP2	LIHC	chr3	185410502	185410502	C	A	Missense_Mutation		1

Copy number variation (CNV) of IGF2BP2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across IGF2BP2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
94484	STAD	TCGA-BR-8366-01A	CLDN12	chr7	90034922	+	IGF2BP2	chr3	185390457	-
94484	UCS	TCGA-ND-A4WF-01A	CTNNB1	chr3	41241161	+	IGF2BP2	chr3	185416135	-
94484	N/A	FN172462	HNRNPU	chr1	245017181	+	IGF2BP2	chr3	185443438	-
59067	STAD	TCGA-BR-A4QI-01A	IGF2BP2	chr3	185407343	-	CNPPD1	chr2	220041569	-
103269	UCS	TCGA-ND-A4WF-01A	IGF2BP2	chr3	185540941	-	IFITM1	chr11	314164	+
87285	UCS	TCGA-ND-A4WF-01A	IGF2BP2	chr3	185540941	-	IFITM2	chr11	308231	+
94484	N/A	BX100154	IGF2BP2	chr3	185445145	-	IGF2BP2	chr3	185445977	-
99954	N/A	DL057511	IGF2BP2	chr3	185490614	-	LIPH	chr3	185258332	-
89601	N/A	CQ205210	IGF2BP2	chr3	185383429	+	MAGI3	chr1	113980579	-
88618	COAD	TCGA-CK-5915	IGF2BP2	chr3	185540940	-	MSL2	chr3	135871580	-
102052	BRCA	TCGA-EW-A1PB-01A	IGF2BP2	chr3	185540941	-	NCEH1	chr3	172365904	-
86521	OV	TCGA-09-1667	IGF2BP2	chr3	185540940	-	SRPRB	chr3	133534433	+
98994	LUSC	TCGA-98-8021-01A	IGF2BP2	chr3	185540941	-	ST6GAL1	chr3	186790637	+
101790	OV	TCGA-61-1900	IGF2BP2	chr3	185540940	-	TCF12	chr15	57355947	+
73385	N/A	AX193009	IGF2BP2	chr3	185542185	+	UNC13D	chr17	73823611	-
94484	ESCA	TCGA-R6-A6Y2-01B	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-
94484	N/A	NM_145731	SYNGR1	chr22	39774394	+	IGF2BP2	chr3	185379111	+
94501	N/A	AF057352	TSC22D1	chr13	45076855	-	IGF2BP2	chr3	185542812	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	IGF2BP2	0.00548363311125808	0.15
PCPG	IGF2BP2	0.0374723727068733	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	IGF2BP2	5.84863319024541e-06	0.00019
KIRP	IGF2BP2	0.0369479827444468	1
LGG	IGF2BP2	0.00382741275787944	0.12
BRCA	IGF2BP2	2.36873728058701e-06	7.8e-05
OV	IGF2BP2	0.0146769706379631	0.41
ESCA	IGF2BP2	0.0394699536705752	1
ACC	IGF2BP2	0.0434563804860957	1
THYM	IGF2BP2	0.00644526894327926	0.19
SARC	IGF2BP2	0.0140958788622373	0.41

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0036341	Schizophrenia	1	PSYGENET
C0221765	Chronic schizophrenia	1	PSYGENET