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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: HBS1L (NCBI Gene ID:10767)

Gene Summary

Gene Summary

Gene Information	Gene Name: HBS1L
	Gene ID: 10767
	Gene Symbol	HBS1L
	Gene ID	10767
	Gene Name	HBS1 like translational GTPase
	Synonyms	EF-1a\|ERFS\|HBS1\|HSPC276\|eRF3c
	Cytomap	6q23.3
	Type of Gene	protein-coding
	Description	HBS1-like proteinERF3-similar proteinHsp70 subfamily B suppressor 1-like proteineRF3 family member
	Modification date	20200313
	UniProtAcc	Q9Y450

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'HBS1L[title] AND translation [title] AND human.'

Gene	Title	PMID
HBS1L	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000367837	135290375	135290476	Frame-shift
ENST00000367837	135307203	135307321	Frame-shift
ENST00000367837	135360710	135360905	In-frame
ENST00000367837	135363138	135363264	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000367837	135360710	135360905	7180	443	637	684	78	143
ENST00000367837	135363138	135363264	7180	317	442	684	36	78

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9Y450	36	78	1	684	Chain	ID=PRO_0000091491;Note=HBS1-like protein
Q9Y450	78	143	1	684	Chain	ID=PRO_0000091491;Note=HBS1-like protein
Q9Y450	36	78	49	49	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y450	36	78	67	67	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y450	78	143	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q9Y450	78	143	127	127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
Q9Y450	36	78	37	78	Alternative sequence	ID=VSP_041068;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y450	78	143	37	78	Alternative sequence	ID=VSP_041068;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	HBS1L	-3.51830003681254	0.000568486322514105
LUAD	HBS1L	-3.79049220477362	0.00334247187092709
COAD	HBS1L	-2.33101802408262	0.0140064954757691
HNSC	HBS1L	-1.05185243210432	0.0462444565380338

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
HNSC	HBS1L	-0.137346763	0.014064103
UCEC	HBS1L	0.154823278	0.02041731
KIRP	HBS1L	0.053122201	0.042360022

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with HBS1L (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	HBS1L	MANEA	0.831699991	1.48E-12
CHOL	CGC	HBS1L	FGFR1OP	0.852682501	1.06E-13
CHOL	IUPHAR	HBS1L	PREP	0.801122669	3.87E-11
KICH	Cell metabolism gene	HBS1L	SSR1	0.809018737	2.99E-22
KICH	Cell metabolism gene	HBS1L	TCP1	0.850158197	1.59E-26
KICH	CGC	HBS1L	CUL3	0.811962483	1.61E-22
KICH	CGC	HBS1L	CDC73	0.833912562	1.07E-24
KICH	Epifactor	HBS1L	HDAC2	0.808841985	3.10E-22
KICH	Epifactor	HBS1L	UCHL5	0.809962168	2.45E-22
KICH	Epifactor	HBS1L	CUL3	0.811962483	1.61E-22
KICH	Epifactor	HBS1L	MAP3K7	0.821645512	1.91E-23
KICH	Epifactor	HBS1L	CDC73	0.833912562	1.07E-24
KICH	IUPHAR	HBS1L	PRPF4B	0.803565541	9.21E-22
KICH	IUPHAR	HBS1L	HDAC2	0.808841985	3.10E-22
KICH	IUPHAR	HBS1L	MAP3K7	0.821645512	1.91E-23
KICH	Kinase	HBS1L	PRPF4B	0.803565541	9.21E-22
KICH	Kinase	HBS1L	MAP3K7	0.821645512	1.91E-23
KICH	TF	HBS1L	ATF6	0.81758133	4.74E-23
KICH	TSG	HBS1L	CDC73	0.833912562	1.07E-24
PRAD	CGC	HBS1L	BCLAF1	0.862406442	3.74E-164
PRAD	Epifactor	HBS1L	PHF10	0.806543043	3.36E-127
PRAD	TF	HBS1L	CDC5L	0.885689776	9.53E-185
THYM	Cell metabolism gene	HBS1L	TRDMT1	0.801369755	1.49E-28
THYM	Cell metabolism gene	HBS1L	DCP2	0.801881297	1.30E-28
THYM	Cell metabolism gene	HBS1L	CCNC	0.82973537	3.56E-32
THYM	Cell metabolism gene	HBS1L	GALNT7	0.84388883	3.05E-34
THYM	Cell metabolism gene	HBS1L	NFYA	0.845617802	1.65E-34
THYM	CGC	HBS1L	CCNC	0.82973537	3.56E-32
THYM	CGC	HBS1L	TCF12	0.833530352	1.04E-32
THYM	CGC	HBS1L	DEK	0.843339723	3.70E-34
THYM	CGC	HBS1L	FGFR1OP	0.844945355	2.10E-34
THYM	CGC	HBS1L	CTCF	0.850419032	2.88E-35
THYM	Epifactor	HBS1L	MTF2	0.804705353	6.02E-29
THYM	Epifactor	HBS1L	SATB1	0.831186673	2.23E-32
THYM	Epifactor	HBS1L	MSL2	0.842340622	5.25E-34
THYM	Epifactor	HBS1L	DEK	0.843339723	3.70E-34
THYM	Epifactor	HBS1L	CTCF	0.850419032	2.88E-35
THYM	Epifactor	HBS1L	JARID2	0.857619725	1.87E-36
THYM	IUPHAR	HBS1L	CRY1	0.800847464	1.72E-28
THYM	IUPHAR	HBS1L	ABCD3	0.814686731	3.56E-30
THYM	TF	HBS1L	MTF2	0.804705353	6.02E-29
THYM	TF	HBS1L	E2F7	0.805141241	5.34E-29
THYM	TF	HBS1L	ZBTB2	0.806637531	3.53E-29
THYM	TF	HBS1L	CGGBP1	0.81400651	4.34E-30
THYM	TF	HBS1L	SATB1	0.831186673	2.23E-32
THYM	TF	HBS1L	TCF12	0.833530352	1.04E-32
THYM	TF	HBS1L	NFYA	0.845617802	1.65E-34
THYM	TF	HBS1L	ZNF280D	0.846740765	1.10E-34
THYM	TF	HBS1L	CTCF	0.850419032	2.88E-35
THYM	TSG	HBS1L	CCNC	0.82973537	3.56E-32
THYM	TSG	HBS1L	CTCF	0.850419032	2.88E-35
UCS	Cell metabolism gene	HBS1L	TRDMT1	0.801369755	1.49E-28
UCS	Cell metabolism gene	HBS1L	DCP2	0.801881297	1.30E-28
UCS	Cell metabolism gene	HBS1L	CCNC	0.82973537	3.56E-32
UCS	Cell metabolism gene	HBS1L	GALNT7	0.84388883	3.05E-34
UCS	Cell metabolism gene	HBS1L	NFYA	0.845617802	1.65E-34
UCS	CGC	HBS1L	CCNC	0.82973537	3.56E-32
UCS	CGC	HBS1L	TCF12	0.833530352	1.04E-32
UCS	CGC	HBS1L	DEK	0.843339723	3.70E-34
UCS	CGC	HBS1L	FGFR1OP	0.844945355	2.10E-34
UCS	CGC	HBS1L	CTCF	0.850419032	2.88E-35
UCS	Epifactor	HBS1L	MTF2	0.804705353	6.02E-29
UCS	Epifactor	HBS1L	SATB1	0.831186673	2.23E-32
UCS	Epifactor	HBS1L	MSL2	0.842340622	5.25E-34
UCS	Epifactor	HBS1L	DEK	0.843339723	3.70E-34
UCS	Epifactor	HBS1L	CTCF	0.850419032	2.88E-35
UCS	Epifactor	HBS1L	JARID2	0.857619725	1.87E-36
UCS	IUPHAR	HBS1L	CRY1	0.800847464	1.72E-28
UCS	IUPHAR	HBS1L	ABCD3	0.814686731	3.56E-30
UCS	TF	HBS1L	MTF2	0.804705353	6.02E-29
UCS	TF	HBS1L	E2F7	0.805141241	5.34E-29
UCS	TF	HBS1L	ZBTB2	0.806637531	3.53E-29
UCS	TF	HBS1L	CGGBP1	0.81400651	4.34E-30
UCS	TF	HBS1L	SATB1	0.831186673	2.23E-32
UCS	TF	HBS1L	TCF12	0.833530352	1.04E-32
UCS	TF	HBS1L	NFYA	0.845617802	1.65E-34
UCS	TF	HBS1L	ZNF280D	0.846740765	1.10E-34
UCS	TF	HBS1L	CTCF	0.850419032	2.88E-35
UCS	TSG	HBS1L	CCNC	0.82973537	3.56E-32
UCS	TSG	HBS1L	CTCF	0.850419032	2.88E-35
UVM	Cell metabolism gene	HBS1L	GNAQ	0.800611882	4.99E-19
UVM	Cell metabolism gene	HBS1L	TRMT11	0.824349234	5.76E-21
UVM	Cell metabolism gene	HBS1L	MANEA	0.843276618	9.88E-23
UVM	Cell metabolism gene	HBS1L	CCNC	0.857992842	2.83E-24
UVM	Cell metabolism gene	HBS1L	MED23	0.891774258	1.38E-28
UVM	Cell metabolism gene	HBS1L	PGM3	0.898829471	1.14E-29
UVM	Cell metabolism gene	HBS1L	NUP43	0.902831466	2.56E-30
UVM	CGC	HBS1L	GNAQ	0.800611882	4.99E-19
UVM	CGC	HBS1L	LATS1	0.819325843	1.56E-20
UVM	CGC	HBS1L	FGFR1OP	0.846861022	4.30E-23
UVM	CGC	HBS1L	CCNC	0.857992842	2.83E-24
UVM	CGC	HBS1L	BCLAF1	0.860955831	1.32E-24
UVM	CGC	HBS1L	GOPC	0.874366148	3.29E-26
UVM	Epifactor	HBS1L	PHF10	0.801297517	4.42E-19
UVM	Epifactor	HBS1L	SHPRH	0.831011883	1.46E-21
UVM	Epifactor	HBS1L	ASF1A	0.832216992	1.13E-21
UVM	Epifactor	HBS1L	ZMYND11	0.837689949	3.46E-22
UVM	Epifactor	HBS1L	HDAC2	0.860421895	1.52E-24
UVM	IUPHAR	HBS1L	GNAQ	0.800611882	4.99E-19
UVM	IUPHAR	HBS1L	SENP6	0.817417144	2.27E-20
UVM	IUPHAR	HBS1L	LATS1	0.819325843	1.56E-20
UVM	IUPHAR	HBS1L	ZMYND11	0.837689949	3.46E-22
UVM	IUPHAR	HBS1L	MAP3K4	0.842096018	1.29E-22
UVM	IUPHAR	HBS1L	TMEM30A	0.845530043	5.87E-23
UVM	IUPHAR	HBS1L	KATNA1	0.857777795	2.99E-24
UVM	IUPHAR	HBS1L	HDAC2	0.860421895	1.52E-24
UVM	IUPHAR	HBS1L	IFNGR1	0.877496423	1.31E-26
UVM	Kinase	HBS1L	LATS1	0.819325843	1.56E-20
UVM	Kinase	HBS1L	MAP3K4	0.842096018	1.29E-22
UVM	TF	HBS1L	ZNF292	0.80748426	1.46E-19
UVM	TF	HBS1L	HIVEP2	0.811491545	6.98E-20
UVM	TF	HBS1L	HSF2	0.836280614	4.71E-22
UVM	TF	HBS1L	ZBTB2	0.847155121	4.02E-23
UVM	TF	HBS1L	TBPL1	0.861028968	1.29E-24
UVM	TF	HBS1L	ZUFSP	0.907584733	3.97E-31
UVM	TSG	HBS1L	ZNF292	0.80748426	1.46E-19
UVM	TSG	HBS1L	LATS1	0.819325843	1.56E-20
UVM	TSG	HBS1L	HACE1	0.828910359	2.26E-21
UVM	TSG	HBS1L	PDSS2	0.829669103	1.93E-21
UVM	TSG	HBS1L	SHPRH	0.831011883	1.46E-21
UVM	TSG	HBS1L	ZMYND11	0.837689949	3.46E-22
UVM	TSG	HBS1L	MAP3K4	0.842096018	1.29E-22
UVM	TSG	HBS1L	CCNC	0.857992842	2.83E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	HBS1L	UPF1	-1.33899089151335	0.000117696606626909
KIRP	HBS1L	EXOSC1	-1.33151185162103	0.000133869703859091
LIHC	HBS1L	EXOSC9	-2.50953051098706	0.000201991820198738
STAD	HBS1L	EXOSC9	-1.45226188044018	0.000306400004774332
BRCA	HBS1L	EXOSC8	1.08712582334317	0.000406553655147176
KICH	HBS1L	EXOSC1	1.88198428035622	0.000556409358978271
COAD	HBS1L	EXOSC9	-2.08916035369094	0.000664144754409791
BRCA	HBS1L	ABCE1	1.3740626146648	0.000669229587514616
ESCA	HBS1L	EXOSC5	-3.73448090208876	0.0009765625
KICH	HBS1L	EXOSC8	1.23640295139634	0.00162535905838013
LUSC	HBS1L	PELO	-1.82668407726044	0.00188801965955652
ESCA	HBS1L	EXOSC9	-1.29616499696761	0.0029296875
LIHC	HBS1L	ABCE1	1.33775121002715	0.0033398145023608
LIHC	HBS1L	UPF1	-1.92491321082533	0.00427166918402987
STAD	HBS1L	EXOSC3	-1.95167394249126	0.00733334058895707
KICH	HBS1L	EXOSC7	1.11626022550606	0.00963503122329712
LUSC	HBS1L	EXOSC8	-1.2171400553766	0.0105240117726964
HNSC	HBS1L	ABCE1	1.20332081233659	0.0124875666290336
LUAD	HBS1L	PELO	1.12439241636824	0.013228736909195
UCEC	HBS1L	EXOSC7	1.37141709218626	0.015625
BLCA	HBS1L	ABCE1	-4.08863120087471	0.0229873657226562
LUAD	HBS1L	EXOSC9	-1.70965354341598	0.0417265102143948
KIRC	HBS1L	PELO	1.18792208845578	1.01627574891071e-11
BRCA	HBS1L	EXOSC1	-3.22250485955442	1.01918341406027e-11
KIRC	HBS1L	EXOSC5	-2.76908351745065	1.09859684701495e-11
KIRC	HBS1L	EXOSC9	-1.80547222200586	1.11862284037858e-09
PRAD	HBS1L	EXOSC5	-2.70222350851716	1.26099370313262e-05
PRAD	HBS1L	ABCE1	-2.9089513514626	1.31460603050763e-05
THCA	HBS1L	EXOSC5	-1.76982463038815	1.55304155962675e-06
LUAD	HBS1L	EXOSC5	-2.21263383713822	1.8775400044567e-09
PRAD	HBS1L	UPF1	1.18312136515194	3.77428293642232e-05
LUAD	HBS1L	EXOSC3	-2.13410426948851	5.48906105617824e-05
KIRP	HBS1L	EXOSC5	-1.57899571115575	6.79492950439454e-06
THCA	HBS1L	EXOSC3	1.35051614908302	7.77019962091197e-05
BRCA	HBS1L	EXOSC5	-1.24930553971161	9.66917351405126e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with HBS1L

CUL3, HTT, DIS3L, APP, CPLX1, LYN, UBE2G2, SRPK2, SRPK1, FANCI, PELO, MAP3K1, CACNG2, MSX2, EXOSC3, EXOSC7, EXOSC8, STK25, EIF2S3, RPS20, RPS5, NTRK1, CEP19, XPO1, EXOSC9, Rpl35, Exosc1, EXOSC6, EXOSC5, EXOSC4, EXOSC1, EIF1AD, ISOC2, RAB39B, JMJD6, UHRF1, LIN9, GCHFR, LAMP3, CIT, GFI1B, HBS1L, INTS5, PSMD1, WDR61, HIF1AN, EGLN3, EFTUD2, ARIH1, HECTD1, RECQL4, MYC, NR2C2, BICD2, HOOK3, APEX1, STAU1, BRD7, ESR1, INS, Rnf183, COPS5, EIF4E2, GIGYF2, MPHOSPH6, SKIV2L2, ZCCHC8, EXOSC10, EXOSC2, RBM7, TULP3, DDRGK1, TP53, NBR1, CXCR4, CD6, ISCA2, CCDC85A, SLC31A1, PRPS2, C1orf35, HS1BP3, GOPC, PIPSL, C11orf87, PTGES3, PIAS4, FAXC, DNAJA2, FAM133A, SURF6, GPX1, AIFM1, LIPA, DTYMK, EPB41L5, EP300, SIRT6,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
HBS1L	chr6	135287462	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
HBS1L	chr6	135323961	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
HBS1L	chr6	135323972	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
HBS1L	chr6	135371730	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
HBS1L	chr6	135371763	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
HBS1L	chr6	135376209	T	G	single_nucleotide_variant	Uncertain_significance	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene

Cancer type

Chromosome

Start

End

RefSeeq

MutSeq

Mutation type

AAchange

# samples

Copy number variation (CNV) of HBS1L
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Fusion gene breakpoints (product of the structural variants (SVs)) across HBS1L
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97743	PAAD	TCGA-IB-A7LX-01A	AHI1	chr6	135715914	-	HBS1L	chr6	135287611	-
98257	ESCA	TCGA-L5-A8NE	HBS1L	chr6	135360710	-	AHI1	chr6	135788772	-
101518	BRCA	TCGA-BH-A1F0-01A	HBS1L	chr6	135318535	-	ARMC2	chr6	109197346	+
35724	PRAD	TCGA-EJ-7794	HBS1L	chr6	135371719	-	IL9	chr5	135228199	-
35724	PRAD	TCGA-EJ-7794-01A	HBS1L	chr6	135371719	-	IL9	chr5	135228198	-
35724	PRAD	TCGA-EJ-7794-01A	HBS1L	chr6	135371720	-	IL9	chr5	135228199	-
102823	LIHC	TCGA-CC-A7IH	HBS1L	chr6	135360710	-	POLN	chr4	2087471	-
89398	Non-Cancer	2397N	HBS1L	chr6	135360710	-	RWDD1	chr6	116901457	+
90875	STAD	TCGA-VQ-A8PD	HBS1L	chr6	135375786	-	SCAF8	chr6	155095122	+
97743	BRCA	TCGA-E2-A155	MBOAT1	chr6	20212366	-	HBS1L	chr6	135371785	-
97743	BRCA	TCGA-E2-A155-01A	MBOAT1	chr6	20212367	-	HBS1L	chr6	135371785	-
97743	N/A	AJ711522	NDUFA9	chr12	4796399	+	HBS1L	chr6	135401752	+
97743	N/A	CV361974	PGBD5	chr1	230480916	-	HBS1L	chr6	135304634	-
97743	N/A	CB051421	SIDT1	chr3	113307458	-	HBS1L	chr6	135314899	+
97743	BRCA	TCGA-BH-A1F0-01A	TBC1D32	chr6	121600267	-	HBS1L	chr6	135315013	-
97771	BRCA	TCGA-C8-A26Z	UTRN	chr6	144999714	+	HBS1L	chr6	135323980	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	HBS1L	0.00191880420512463	0.054
PAAD	HBS1L	0.0159920199316118	0.43
TGCT	HBS1L	0.0194133458664829	0.5
ESCA	HBS1L	0.0417460706389637	1
HNSC	HBS1L	0.0437997915448222	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
OV	HBS1L	7.17167540027826e-06	0.00024

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source