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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EXOSC8 (NCBI Gene ID:11340)

Gene Summary

Gene Summary

Gene Information	Gene Name: EXOSC8
	Gene ID: 11340
	Gene Symbol	EXOSC8
	Gene ID	11340
	Gene Name	exosome component 8
	Synonyms	CIP3\|EAP2\|OIP2\|PCH1C\|RRP43\|Rrp43p\|bA421P11.3\|p9
	Cytomap	13q13.3
	Type of Gene	protein-coding
	Description	exosome complex component RRP43CBP-interacting protein 3OIP-2Opa interacting protein 2exosome complex exonuclease RRP43ribosomal RNA-processing protein 43
	Modification date	20200313
	UniProtAcc	Q96B26

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EXOSC8	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EXOSC8[title] AND translation [title] AND human.'

Gene	Title	PMID
EXOSC8	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000389704	37576409	37576446	Frame-shift
ENST00000389704	37577070	37577144	Frame-shift
ENST00000389704	37578652	37578698	Frame-shift
ENST00000389704	37580251	37580297	Frame-shift
ENST00000389704	37582865	37582972	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	EXOSC8	1.08712582334317	0.000406553655147176
KICH	EXOSC8	1.23640295139634	0.00162535905838013
LUSC	EXOSC8	-1.2171400553766	0.0105240117726964

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BRCA	EXOSC8	-0.07625221	0.006499618

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EXOSC8 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	EXOSC8	ALG5	0.811984393	1.88E-78
COAD	Epifactor	EXOSC8	HMGB1	0.843632858	2.50E-90
COAD	IUPHAR	EXOSC8	UCHL3	0.802972505	1.77E-75
GBM	Epifactor	EXOSC8	HMGB1	0.826547087	2.73E-44
SKCM	Epifactor	EXOSC8	HMGB1	0.831807083	9.43E-123
TGCT	Cell metabolism gene	EXOSC8	TIMM50	0.826437271	2.96E-40
TGCT	Epifactor	EXOSC8	SAP18	0.821830642	1.84E-39
THYM	Cell metabolism gene	EXOSC8	AAAS	0.809010167	1.81E-29
THYM	Cell metabolism gene	EXOSC8	PSMA6	0.809648185	1.51E-29
THYM	Cell metabolism gene	EXOSC8	PSMA4	0.811502061	8.93E-30
THYM	Cell metabolism gene	EXOSC8	ACTB	0.812570227	6.57E-30
THYM	Cell metabolism gene	EXOSC8	SNRPD1	0.815593495	2.73E-30
THYM	Cell metabolism gene	EXOSC8	EXOSC1	0.816577151	2.04E-30
THYM	Cell metabolism gene	EXOSC8	APOA1	0.821028232	5.39E-31
THYM	Cell metabolism gene	EXOSC8	TXN	0.823016298	2.94E-31
THYM	Cell metabolism gene	EXOSC8	SNRPG	0.823484583	2.54E-31
THYM	Cell metabolism gene	EXOSC8	PSMD13	0.824291221	1.98E-31
THYM	Cell metabolism gene	EXOSC8	DUT	0.826850146	8.91E-32
THYM	Cell metabolism gene	EXOSC8	SEC61B	0.829651118	3.66E-32
THYM	Cell metabolism gene	EXOSC8	GNG5	0.840712802	9.23E-34
THYM	Cell metabolism gene	EXOSC8	SNRPF	0.863848318	1.55E-37
THYM	Cell metabolism gene	EXOSC8	ZNRD1	0.87624852	7.38E-40
THYM	Cell metabolism gene	EXOSC8	LSM5	0.877807852	3.62E-40
THYM	CGC	EXOSC8	EWSR1	0.805972766	4.24E-29
THYM	CGC	EXOSC8	FANCG	0.816511383	2.08E-30
THYM	CGC	EXOSC8	CCND3	0.822583343	3.35E-31
THYM	CGC	EXOSC8	U2AF1	0.857744823	1.78E-36
THYM	CGC	EXOSC8	H3F3A	0.887622854	3.22E-42
THYM	Epifactor	EXOSC8	TRIM28	0.800099703	2.10E-28
THYM	Epifactor	EXOSC8	SUV420H2	0.800832673	1.73E-28
THYM	Epifactor	EXOSC8	HIST1H2AJ	0.804033847	7.24E-29
THYM	Epifactor	EXOSC8	HIRIP3	0.804989094	5.57E-29
THYM	Epifactor	EXOSC8	PRMT7	0.805995617	4.22E-29
THYM	Epifactor	EXOSC8	RAD54L	0.810269238	1.27E-29
THYM	Epifactor	EXOSC8	HIST2H2AC	0.811146826	9.89E-30
THYM	Epifactor	EXOSC8	ACTB	0.812570227	6.57E-30
THYM	Epifactor	EXOSC8	H2AFZ	0.812900835	5.98E-30
THYM	Epifactor	EXOSC8	EXOSC1	0.816577151	2.04E-30
THYM	Epifactor	EXOSC8	PADI4	0.817292473	1.65E-30
THYM	Epifactor	EXOSC8	VRK1	0.820977766	5.47E-31
THYM	Epifactor	EXOSC8	CDK9	0.823987324	2.18E-31
THYM	Epifactor	EXOSC8	AURKB	0.826764582	9.15E-32
THYM	Epifactor	EXOSC8	HIST1H3F	0.829088863	4.38E-32
THYM	Epifactor	EXOSC8	SS18L2	0.839780916	1.27E-33
THYM	Epifactor	EXOSC8	ANP32B	0.840148712	1.12E-33
THYM	Epifactor	EXOSC8	HMGB1	0.840297134	1.07E-33
THYM	Epifactor	EXOSC8	MAZ	0.844271304	2.66E-34
THYM	Epifactor	EXOSC8	H1FX	0.845544256	1.69E-34
THYM	Epifactor	EXOSC8	HIST1H2BH	0.850084912	3.26E-35
THYM	Epifactor	EXOSC8	H2AFX	0.862252859	2.96E-37
THYM	Epifactor	EXOSC8	RBX1	0.865629433	7.43E-38
THYM	Epifactor	EXOSC8	HMGN2	0.877635845	3.92E-40
THYM	Epifactor	EXOSC8	NASP	0.881188155	7.46E-41
THYM	Epifactor	EXOSC8	H3F3A	0.887622854	3.22E-42
THYM	IUPHAR	EXOSC8	TRIM28	0.800099703	2.10E-28
THYM	IUPHAR	EXOSC8	TOP1MT	0.801705529	1.37E-28
THYM	IUPHAR	EXOSC8	PRMT7	0.805995617	4.22E-29
THYM	IUPHAR	EXOSC8	PADI4	0.817292473	1.65E-30
THYM	IUPHAR	EXOSC8	VRK1	0.820977766	5.47E-31
THYM	IUPHAR	EXOSC8	PPIA	0.821014658	5.41E-31
THYM	IUPHAR	EXOSC8	CSNK2B	0.821462498	4.72E-31
THYM	IUPHAR	EXOSC8	CDK9	0.823987324	2.18E-31
THYM	IUPHAR	EXOSC8	AURKB	0.826764582	9.15E-32
THYM	IUPHAR	EXOSC8	CTRL	0.832483474	1.46E-32
THYM	IUPHAR	EXOSC8	RGS10	0.873271237	2.80E-39
THYM	Kinase	EXOSC8	TRIM28	0.800099703	2.10E-28
THYM	Kinase	EXOSC8	VRK1	0.820977766	5.47E-31
THYM	Kinase	EXOSC8	CDK9	0.823987324	2.18E-31
THYM	Kinase	EXOSC8	AURKB	0.826764582	9.15E-32
THYM	TF	EXOSC8	PBX4	0.811098757	1.00E-29
THYM	TF	EXOSC8	MAZ	0.844271304	2.66E-34
THYM	TF	EXOSC8	ZNF444	0.845947265	1.47E-34
THYM	TF	EXOSC8	THYN1	0.870286746	1.03E-38
THYM	TF	EXOSC8	MXD3	0.876128306	7.80E-40
THYM	TF	EXOSC8	GTF3A	0.881030977	8.04E-41
THYM	TSG	EXOSC8	PTPN2	0.803524437	8.32E-29
THYM	TSG	EXOSC8	PFN1	0.803856015	7.60E-29
THYM	TSG	EXOSC8	FANCG	0.816511383	2.08E-30
THYM	TSG	EXOSC8	HTRA2	0.841906012	6.11E-34
THYM	TSG	EXOSC8	AIP	0.850552861	2.74E-35
THYM	TSG	EXOSC8	H2AFX	0.862252859	2.96E-37
UCS	Cell metabolism gene	EXOSC8	AAAS	0.809010167	1.81E-29
UCS	Cell metabolism gene	EXOSC8	PSMA6	0.809648185	1.51E-29
UCS	Cell metabolism gene	EXOSC8	PSMA4	0.811502061	8.93E-30
UCS	Cell metabolism gene	EXOSC8	ACTB	0.812570227	6.57E-30
UCS	Cell metabolism gene	EXOSC8	SNRPD1	0.815593495	2.73E-30
UCS	Cell metabolism gene	EXOSC8	EXOSC1	0.816577151	2.04E-30
UCS	Cell metabolism gene	EXOSC8	APOA1	0.821028232	5.39E-31
UCS	Cell metabolism gene	EXOSC8	TXN	0.823016298	2.94E-31
UCS	Cell metabolism gene	EXOSC8	SNRPG	0.823484583	2.54E-31
UCS	Cell metabolism gene	EXOSC8	PSMD13	0.824291221	1.98E-31
UCS	Cell metabolism gene	EXOSC8	DUT	0.826850146	8.91E-32
UCS	Cell metabolism gene	EXOSC8	SEC61B	0.829651118	3.66E-32
UCS	Cell metabolism gene	EXOSC8	GNG5	0.840712802	9.23E-34
UCS	Cell metabolism gene	EXOSC8	SNRPF	0.863848318	1.55E-37
UCS	Cell metabolism gene	EXOSC8	ZNRD1	0.87624852	7.38E-40
UCS	Cell metabolism gene	EXOSC8	LSM5	0.877807852	3.62E-40
UCS	CGC	EXOSC8	EWSR1	0.805972766	4.24E-29
UCS	CGC	EXOSC8	FANCG	0.816511383	2.08E-30
UCS	CGC	EXOSC8	CCND3	0.822583343	3.35E-31
UCS	CGC	EXOSC8	U2AF1	0.857744823	1.78E-36
UCS	CGC	EXOSC8	H3F3A	0.887622854	3.22E-42
UCS	Epifactor	EXOSC8	TRIM28	0.800099703	2.10E-28
UCS	Epifactor	EXOSC8	SUV420H2	0.800832673	1.73E-28
UCS	Epifactor	EXOSC8	HIST1H2AJ	0.804033847	7.24E-29
UCS	Epifactor	EXOSC8	HIRIP3	0.804989094	5.57E-29
UCS	Epifactor	EXOSC8	PRMT7	0.805995617	4.22E-29
UCS	Epifactor	EXOSC8	RAD54L	0.810269238	1.27E-29
UCS	Epifactor	EXOSC8	HIST2H2AC	0.811146826	9.89E-30
UCS	Epifactor	EXOSC8	ACTB	0.812570227	6.57E-30
UCS	Epifactor	EXOSC8	H2AFZ	0.812900835	5.98E-30
UCS	Epifactor	EXOSC8	EXOSC1	0.816577151	2.04E-30
UCS	Epifactor	EXOSC8	PADI4	0.817292473	1.65E-30
UCS	Epifactor	EXOSC8	VRK1	0.820977766	5.47E-31
UCS	Epifactor	EXOSC8	CDK9	0.823987324	2.18E-31
UCS	Epifactor	EXOSC8	AURKB	0.826764582	9.15E-32
UCS	Epifactor	EXOSC8	HIST1H3F	0.829088863	4.38E-32
UCS	Epifactor	EXOSC8	SS18L2	0.839780916	1.27E-33
UCS	Epifactor	EXOSC8	ANP32B	0.840148712	1.12E-33
UCS	Epifactor	EXOSC8	HMGB1	0.840297134	1.07E-33
UCS	Epifactor	EXOSC8	MAZ	0.844271304	2.66E-34
UCS	Epifactor	EXOSC8	H1FX	0.845544256	1.69E-34
UCS	Epifactor	EXOSC8	HIST1H2BH	0.850084912	3.26E-35
UCS	Epifactor	EXOSC8	H2AFX	0.862252859	2.96E-37
UCS	Epifactor	EXOSC8	RBX1	0.865629433	7.43E-38
UCS	Epifactor	EXOSC8	HMGN2	0.877635845	3.92E-40
UCS	Epifactor	EXOSC8	NASP	0.881188155	7.46E-41
UCS	Epifactor	EXOSC8	H3F3A	0.887622854	3.22E-42
UCS	IUPHAR	EXOSC8	TRIM28	0.800099703	2.10E-28
UCS	IUPHAR	EXOSC8	TOP1MT	0.801705529	1.37E-28
UCS	IUPHAR	EXOSC8	PRMT7	0.805995617	4.22E-29
UCS	IUPHAR	EXOSC8	PADI4	0.817292473	1.65E-30
UCS	IUPHAR	EXOSC8	VRK1	0.820977766	5.47E-31
UCS	IUPHAR	EXOSC8	PPIA	0.821014658	5.41E-31
UCS	IUPHAR	EXOSC8	CSNK2B	0.821462498	4.72E-31
UCS	IUPHAR	EXOSC8	CDK9	0.823987324	2.18E-31
UCS	IUPHAR	EXOSC8	AURKB	0.826764582	9.15E-32
UCS	IUPHAR	EXOSC8	CTRL	0.832483474	1.46E-32
UCS	IUPHAR	EXOSC8	RGS10	0.873271237	2.80E-39
UCS	Kinase	EXOSC8	TRIM28	0.800099703	2.10E-28
UCS	Kinase	EXOSC8	VRK1	0.820977766	5.47E-31
UCS	Kinase	EXOSC8	CDK9	0.823987324	2.18E-31
UCS	Kinase	EXOSC8	AURKB	0.826764582	9.15E-32
UCS	TF	EXOSC8	PBX4	0.811098757	1.00E-29
UCS	TF	EXOSC8	MAZ	0.844271304	2.66E-34
UCS	TF	EXOSC8	ZNF444	0.845947265	1.47E-34
UCS	TF	EXOSC8	THYN1	0.870286746	1.03E-38
UCS	TF	EXOSC8	MXD3	0.876128306	7.80E-40
UCS	TF	EXOSC8	GTF3A	0.881030977	8.04E-41
UCS	TSG	EXOSC8	PTPN2	0.803524437	8.32E-29
UCS	TSG	EXOSC8	PFN1	0.803856015	7.60E-29
UCS	TSG	EXOSC8	FANCG	0.816511383	2.08E-30
UCS	TSG	EXOSC8	HTRA2	0.841906012	6.11E-34
UCS	TSG	EXOSC8	AIP	0.850552861	2.74E-35
UCS	TSG	EXOSC8	H2AFX	0.862252859	2.96E-37
UVM	Cell metabolism gene	EXOSC8	GLUD1	0.800253294	5.31E-19
UVM	Cell metabolism gene	EXOSC8	GPD2	0.800674452	4.93E-19
UVM	Cell metabolism gene	EXOSC8	PIK3C2A	0.802364289	3.66E-19
UVM	Cell metabolism gene	EXOSC8	SEH1L	0.802810215	3.38E-19
UVM	Cell metabolism gene	EXOSC8	PRKAA1	0.809003171	1.11E-19
UVM	Cell metabolism gene	EXOSC8	CNOT8	0.810006495	9.19E-20
UVM	Cell metabolism gene	EXOSC8	MED7	0.810324832	8.67E-20
UVM	Cell metabolism gene	EXOSC8	CCT2	0.815139577	3.51E-20
UVM	Cell metabolism gene	EXOSC8	MED17	0.815485304	3.28E-20
UVM	Cell metabolism gene	EXOSC8	FAR1	0.816829159	2.54E-20
UVM	Cell metabolism gene	EXOSC8	NUPL2	0.817793619	2.11E-20
UVM	Cell metabolism gene	EXOSC8	PITPNB	0.819040633	1.65E-20
UVM	Cell metabolism gene	EXOSC8	PSMD14	0.823114972	7.38E-21
UVM	Cell metabolism gene	EXOSC8	UGGT2	0.827729691	2.89E-21
UVM	Cell metabolism gene	EXOSC8	CNOT2	0.830997966	1.46E-21
UVM	Cell metabolism gene	EXOSC8	MTMR6	0.836055794	4.95E-22
UVM	Cell metabolism gene	EXOSC8	NUP50	0.846552347	4.63E-23
UVM	Cell metabolism gene	EXOSC8	VAPA	0.847690247	3.54E-23
UVM	Cell metabolism gene	EXOSC8	DIS3	0.85716479	3.49E-24
UVM	Cell metabolism gene	EXOSC8	PSMA4	0.86078857	1.38E-24
UVM	Cell metabolism gene	EXOSC8	XPO1	0.867707769	2.16E-25
UVM	Cell metabolism gene	EXOSC8	NUP107	0.873086309	4.77E-26
UVM	Cell metabolism gene	EXOSC8	PSMC6	0.874483583	3.18E-26
UVM	Cell metabolism gene	EXOSC8	MED4	0.894496534	5.39E-29
UVM	CGC	EXOSC8	DDX5	0.802810386	3.38E-19
UVM	CGC	EXOSC8	SMARCE1	0.817587547	2.19E-20
UVM	CGC	EXOSC8	POT1	0.817848163	2.08E-20
UVM	CGC	EXOSC8	FBXO11	0.818060587	2.00E-20
UVM	CGC	EXOSC8	PWWP2A	0.820812484	1.17E-20
UVM	CGC	EXOSC8	GOLGA5	0.821719053	9.75E-21
UVM	CGC	EXOSC8	TCF12	0.823973397	6.21E-21
UVM	CGC	EXOSC8	TRIM24	0.827781817	2.86E-21
UVM	CGC	EXOSC8	EZH2	0.828521555	2.45E-21
UVM	CGC	EXOSC8	STAG2	0.830056119	1.78E-21
UVM	CGC	EXOSC8	ARID2	0.831802475	1.23E-21
UVM	CGC	EXOSC8	SF3B1	0.835996956	5.01E-22
UVM	CGC	EXOSC8	BMPR1A	0.844626788	7.24E-23
UVM	CGC	EXOSC8	BAZ1A	0.856622912	4.01E-24
UVM	CGC	EXOSC8	XPO1	0.867707769	2.16E-25
UVM	CGC	EXOSC8	PMS1	0.868967867	1.53E-25
UVM	CGC	EXOSC8	ZMYM2	0.869493396	1.32E-25
UVM	CGC	EXOSC8	ATM	0.883196272	2.28E-27
UVM	Epifactor	EXOSC8	TAF5	0.800865207	4.77E-19
UVM	Epifactor	EXOSC8	USP15	0.801868128	4.00E-19
UVM	Epifactor	EXOSC8	LEO1	0.804624232	2.45E-19
UVM	Epifactor	EXOSC8	TLK1	0.80674673	1.67E-19
UVM	Epifactor	EXOSC8	PHF20L1	0.807110082	1.56E-19
UVM	Epifactor	EXOSC8	CBX3	0.807620726	1.42E-19
UVM	Epifactor	EXOSC8	SMARCA5	0.808233699	1.27E-19
UVM	Epifactor	EXOSC8	PRKAA1	0.809003171	1.11E-19
UVM	Epifactor	EXOSC8	NIPBL	0.811028673	7.61E-20
UVM	Epifactor	EXOSC8	TDG	0.81683048	2.54E-20
UVM	Epifactor	EXOSC8	SMARCAD1	0.81710703	2.40E-20
UVM	Epifactor	EXOSC8	SMEK2	0.817143195	2.39E-20
UVM	Epifactor	EXOSC8	ATAD2B	0.817168856	2.38E-20
UVM	Epifactor	EXOSC8	SMARCE1	0.817587547	2.19E-20
UVM	Epifactor	EXOSC8	RAD54B	0.81976811	1.43E-20
UVM	Epifactor	EXOSC8	OGT	0.820391873	1.27E-20
UVM	Epifactor	EXOSC8	CIR1	0.822117293	9.01E-21
UVM	Epifactor	EXOSC8	INO80D	0.82223048	8.81E-21
UVM	Epifactor	EXOSC8	AEBP2	0.822236239	8.80E-21
UVM	Epifactor	EXOSC8	TRIM24	0.827781817	2.86E-21
UVM	Epifactor	EXOSC8	EZH2	0.828521555	2.45E-21
UVM	Epifactor	EXOSC8	NSL1	0.829269301	2.10E-21
UVM	Epifactor	EXOSC8	ARID2	0.831802475	1.23E-21
UVM	Epifactor	EXOSC8	CUL2	0.834042804	7.65E-22
UVM	Epifactor	EXOSC8	SF3B1	0.835996956	5.01E-22
UVM	Epifactor	EXOSC8	ARID4A	0.836489281	4.50E-22
UVM	Epifactor	EXOSC8	BRWD1	0.838345511	2.99E-22
UVM	Epifactor	EXOSC8	GATAD1	0.840817374	1.73E-22
UVM	Epifactor	EXOSC8	VRK1	0.84131877	1.54E-22
UVM	Epifactor	EXOSC8	JMJD1C	0.845005324	6.63E-23
UVM	Epifactor	EXOSC8	MASTL	0.855062472	5.92E-24
UVM	Epifactor	EXOSC8	BAZ1A	0.856622912	4.01E-24
UVM	Epifactor	EXOSC8	ACTR6	0.856952822	3.69E-24
UVM	Epifactor	EXOSC8	SMEK1	0.859286534	2.03E-24
UVM	Epifactor	EXOSC8	ZMYM2	0.869493396	1.32E-25
UVM	Epifactor	EXOSC8	TAF7	0.873432921	4.32E-26
UVM	Epifactor	EXOSC8	ATM	0.883196272	2.28E-27
UVM	Epifactor	EXOSC8	HMGB1	0.892374684	1.12E-28
UVM	IUPHAR	EXOSC8	PIK3C2A	0.802364289	3.66E-19
UVM	IUPHAR	EXOSC8	MAP4K3	0.802878567	3.34E-19
UVM	IUPHAR	EXOSC8	TNKS2	0.804438495	2.53E-19
UVM	IUPHAR	EXOSC8	CYP2R1	0.804669752	2.43E-19
UVM	IUPHAR	EXOSC8	XIAP	0.80615648	1.86E-19
UVM	IUPHAR	EXOSC8	TLK1	0.80674673	1.67E-19
UVM	IUPHAR	EXOSC8	PRKAA1	0.809003171	1.11E-19
UVM	IUPHAR	EXOSC8	ATP2B1	0.809572522	9.96E-20
UVM	IUPHAR	EXOSC8	STK17A	0.810101168	9.04E-20
UVM	IUPHAR	EXOSC8	ABCB10	0.810942113	7.73E-20
UVM	IUPHAR	EXOSC8	CSNK1A1	0.812715157	5.55E-20
UVM	IUPHAR	EXOSC8	TBK1	0.813778613	4.54E-20
UVM	IUPHAR	EXOSC8	NAPEPLD	0.815678032	3.16E-20
UVM	IUPHAR	EXOSC8	ATAD2B	0.817168856	2.38E-20
UVM	IUPHAR	EXOSC8	FBXO11	0.818060587	2.00E-20
UVM	IUPHAR	EXOSC8	PSMD14	0.823114972	7.38E-21
UVM	IUPHAR	EXOSC8	TRIM24	0.827781817	2.86E-21
UVM	IUPHAR	EXOSC8	IRAK4	0.828416049	2.51E-21
UVM	IUPHAR	EXOSC8	EZH2	0.828521555	2.45E-21
UVM	IUPHAR	EXOSC8	NR2C1	0.835286804	5.85E-22
UVM	IUPHAR	EXOSC8	PLK4	0.835920464	5.10E-22
UVM	IUPHAR	EXOSC8	BRWD1	0.838345511	2.99E-22
UVM	IUPHAR	EXOSC8	VRK1	0.84131877	1.54E-22
UVM	IUPHAR	EXOSC8	RIOK2	0.844243824	7.91E-23
UVM	IUPHAR	EXOSC8	BMPR1A	0.844626788	7.24E-23
UVM	IUPHAR	EXOSC8	JMJD1C	0.845005324	6.63E-23
UVM	IUPHAR	EXOSC8	MASTL	0.855062472	5.92E-24
UVM	IUPHAR	EXOSC8	BAZ1A	0.856622912	4.01E-24
UVM	IUPHAR	EXOSC8	XPO1	0.867707769	2.16E-25
UVM	IUPHAR	EXOSC8	ATM	0.883196272	2.28E-27
UVM	IUPHAR	EXOSC8	MARK3	0.902896903	2.49E-30
UVM	Kinase	EXOSC8	MAP4K3	0.802878567	3.34E-19
UVM	Kinase	EXOSC8	TLK1	0.80674673	1.67E-19
UVM	Kinase	EXOSC8	PAN3	0.808178292	1.29E-19
UVM	Kinase	EXOSC8	PRKAA1	0.809003171	1.11E-19
UVM	Kinase	EXOSC8	STK17A	0.810101168	9.04E-20
UVM	Kinase	EXOSC8	CSNK1A1	0.812715157	5.55E-20
UVM	Kinase	EXOSC8	TBK1	0.813778613	4.54E-20
UVM	Kinase	EXOSC8	TRIM24	0.827781817	2.86E-21
UVM	Kinase	EXOSC8	IRAK4	0.828416049	2.51E-21
UVM	Kinase	EXOSC8	PLK4	0.835920464	5.10E-22
UVM	Kinase	EXOSC8	VRK1	0.84131877	1.54E-22
UVM	Kinase	EXOSC8	RIOK2	0.844243824	7.91E-23
UVM	Kinase	EXOSC8	BMPR1A	0.844626788	7.24E-23
UVM	Kinase	EXOSC8	MASTL	0.855062472	5.92E-24
UVM	Kinase	EXOSC8	BAZ1A	0.856622912	4.01E-24
UVM	Kinase	EXOSC8	ATM	0.883196272	2.28E-27
UVM	Kinase	EXOSC8	MARK3	0.902896903	2.49E-30
UVM	TF	EXOSC8	ZNF268	0.801816694	4.03E-19
UVM	TF	EXOSC8	ZNF280D	0.80396371	2.76E-19
UVM	TF	EXOSC8	CEBPZ	0.804939229	2.31E-19
UVM	TF	EXOSC8	ZNF200	0.805393846	2.13E-19
UVM	TF	EXOSC8	ZNF180	0.806013055	1.91E-19
UVM	TF	EXOSC8	ZBTB6	0.80711952	1.56E-19
UVM	TF	EXOSC8	ZNF565	0.807218177	1.53E-19
UVM	TF	EXOSC8	ZNF12	0.807452622	1.47E-19
UVM	TF	EXOSC8	ZNF441	0.808357411	1.25E-19
UVM	TF	EXOSC8	ZNF510	0.810136107	8.98E-20
UVM	TF	EXOSC8	ZNF555	0.811748223	6.65E-20
UVM	TF	EXOSC8	ZNF449	0.811976986	6.37E-20
UVM	TF	EXOSC8	ZNF823	0.81269421	5.57E-20
UVM	TF	EXOSC8	ZNF222	0.812969151	5.29E-20
UVM	TF	EXOSC8	ZNF44	0.813069075	5.19E-20
UVM	TF	EXOSC8	ZNF518A	0.814728391	3.79E-20
UVM	TF	EXOSC8	ZNF266	0.815120626	3.52E-20
UVM	TF	EXOSC8	ZNF700	0.816474909	2.72E-20
UVM	TF	EXOSC8	ZNF182	0.817888658	2.07E-20
UVM	TF	EXOSC8	ZNF780A	0.821134058	1.10E-20
UVM	TF	EXOSC8	IKZF5	0.821455046	1.03E-20
UVM	TF	EXOSC8	AEBP2	0.822236239	8.80E-21
UVM	TF	EXOSC8	THAP9	0.822847642	7.79E-21
UVM	TF	EXOSC8	ELF2	0.823789793	6.45E-21
UVM	TF	EXOSC8	TCF12	0.823973397	6.21E-21
UVM	TF	EXOSC8	ZNF195	0.826047382	4.08E-21
UVM	TF	EXOSC8	ZNF527	0.826556683	3.68E-21
UVM	TF	EXOSC8	ZNF181	0.826823959	3.48E-21
UVM	TF	EXOSC8	DMTF1	0.827360269	3.12E-21
UVM	TF	EXOSC8	ZNF84	0.827493024	3.03E-21
UVM	TF	EXOSC8	ZNF451	0.827502267	3.03E-21
UVM	TF	EXOSC8	ZNF33A	0.82785138	2.82E-21
UVM	TF	EXOSC8	ZNF226	0.829839297	1.87E-21
UVM	TF	EXOSC8	RBAK	0.830168818	1.74E-21
UVM	TF	EXOSC8	PRDM10	0.831071789	1.44E-21
UVM	TF	EXOSC8	ARID2	0.831802475	1.23E-21
UVM	TF	EXOSC8	ZNF658	0.832076994	1.16E-21
UVM	TF	EXOSC8	ZNF383	0.833936212	7.83E-22
UVM	TF	EXOSC8	NR2C1	0.835286804	5.85E-22
UVM	TF	EXOSC8	ZNF480	0.835941886	5.07E-22
UVM	TF	EXOSC8	GPBP1	0.837429824	3.67E-22
UVM	TF	EXOSC8	CREBZF	0.840616657	1.81E-22
UVM	TF	EXOSC8	ZNF675	0.84364433	9.08E-23
UVM	TF	EXOSC8	ZNF75D	0.84365829	9.05E-23
UVM	TF	EXOSC8	ZNF546	0.845636584	5.73E-23
UVM	TF	EXOSC8	PURB	0.850873333	1.66E-23
UVM	TF	EXOSC8	ZNF26	0.851695524	1.36E-23
UVM	TF	EXOSC8	ZNF136	0.86074598	1.39E-24
UVM	TF	EXOSC8	ZNF43	0.862198508	9.53E-25
UVM	TF	EXOSC8	ZBTB1	0.865222115	4.26E-25
UVM	TF	EXOSC8	ZNF140	0.868088186	1.95E-25
UVM	TSG	EXOSC8	FAM188A	0.808980602	1.11E-19
UVM	TSG	EXOSC8	PRKAA1	0.809003171	1.11E-19
UVM	TSG	EXOSC8	TBRG1	0.809034319	1.10E-19
UVM	TSG	EXOSC8	CSNK1A1	0.812715157	5.55E-20
UVM	TSG	EXOSC8	APAF1	0.812786787	5.48E-20
UVM	TSG	EXOSC8	DCLRE1A	0.813662988	4.64E-20
UVM	TSG	EXOSC8	NAPEPLD	0.815678032	3.16E-20
UVM	TSG	EXOSC8	KRIT1	0.826953894	3.39E-21
UVM	TSG	EXOSC8	DMTF1	0.827360269	3.12E-21
UVM	TSG	EXOSC8	TRIM24	0.827781817	2.86E-21
UVM	TSG	EXOSC8	EZH2	0.828521555	2.45E-21
UVM	TSG	EXOSC8	ARID2	0.831802475	1.23E-21
UVM	TSG	EXOSC8	CUL2	0.834042804	7.65E-22
UVM	TSG	EXOSC8	GORAB	0.836365029	4.63E-22
UVM	TSG	EXOSC8	INTS6	0.839130404	2.52E-22
UVM	TSG	EXOSC8	BMPR1A	0.844626788	7.24E-23
UVM	TSG	EXOSC8	MLH3	0.845611382	5.76E-23
UVM	TSG	EXOSC8	SMCHD1	0.856635434	3.99E-24
UVM	TSG	EXOSC8	PPP2R5C	0.858478891	2.50E-24
UVM	TSG	EXOSC8	IFT88	0.860605142	1.45E-24
UVM	TSG	EXOSC8	GGNBP2	0.862297619	9.28E-25
UVM	TSG	EXOSC8	PDS5B	0.867611282	2.22E-25
UVM	TSG	EXOSC8	RINT1	0.87766781	1.24E-26
UVM	TSG	EXOSC8	ATM	0.883196272	2.28E-27

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	EXOSC8	EXOSC1	-1.33151185162103	0.000133869703859091
THCA	EXOSC8	EXOSC4	-1.11463631149166	0.000207398306454043
STAD	EXOSC8	EXOSC2	-2.44541936914958	0.000280400272458792
KICH	EXOSC8	EXOSC1	1.88198428035622	0.000556409358978271
PRAD	EXOSC8	SKIV2L2	-1.27775550240692	0.000627023923094011
PRAD	EXOSC8	EXOSC4	-4.70182019022102	0.000648342999076925
ESCA	EXOSC8	EXOSC5	-3.73448090208876	0.0009765625
LIHC	EXOSC8	EXOSC4	2.269913876739	0.00228509329229136
BLCA	EXOSC8	MPHOSPH6	1.68807157110571	0.00457763671875
STAD	EXOSC8	EXOSC3	-1.95167394249126	0.00733334058895707
CHOL	EXOSC8	C1D	-3.47202180778947	0.0078125
KICH	EXOSC8	EXOSC7	1.11626022550606	0.00963503122329712
UCEC	EXOSC8	EXOSC7	1.37141709218626	0.015625
LIHC	EXOSC8	SKIV2L2	-1.18110700879315	0.0175629065961987
KICH	EXOSC8	MPHOSPH6	-1.16662499083698	0.0341737866401672
BRCA	EXOSC8	EXOSC1	-3.22250485955442	1.01918341406027e-11
KIRC	EXOSC8	EXOSC5	-2.76908351745065	1.09859684701495e-11
PRAD	EXOSC8	EXOSC5	-2.70222350851716	1.26099370313262e-05
BRCA	EXOSC8	EXOSC4	-1.39844269640225	1.3684078260725e-15
THCA	EXOSC8	EXOSC5	-1.76982463038815	1.55304155962675e-06
LUAD	EXOSC8	EXOSC5	-2.21263383713822	1.8775400044567e-09
KIRC	EXOSC8	EXOSC2	-1.19651027966078	1.90834783211408e-08
THCA	EXOSC8	SKIV2L2	-3.0696404754071	4.37037666427901e-06
KIRC	EXOSC8	C1D	-2.58201286857152	4.83233501211855e-08
LUAD	EXOSC8	EXOSC4	-2.39057665546458	5.24732369463512e-07
LUAD	EXOSC8	EXOSC3	-2.13410426948851	5.48906105617824e-05
KIRP	EXOSC8	EXOSC5	-1.57899571115575	6.79492950439454e-06
THCA	EXOSC8	EXOSC3	1.35051614908302	7.77019962091197e-05
LUAD	EXOSC8	EXOSC2	-1.64534827889499	8.78996847588964e-09
BRCA	EXOSC8	EXOSC5	-1.24930553971161	9.66917351405126e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EXOSC8

LSM1, LSM7, EXOSC6, EXOSC5, UBC, VHL, Vhl, EXOSC4, DIS3, DIS3L, EXOSC3, MDC1, METTL22, AICDA, FHOD1, RASSF1, MKRN1, CWC22, FOXN3, EXOSC1, EXOSC10, XRN1, XRN2, UPF2, EXOSC8, ZFP36, RPA3, RPA2, RPA1, WDR92, CRMP1, TP53, ATF2, FRG1, REL, SNRPC, TCEA2, TFAP4, USP6, COX5A, TXNDC9, OTUD4, DUSP23, FAM90A1, AEN, TXNDC17, COL23A1, MORN4, MOV10, NXF1, EXOSC7, MPHOSPH6, SKIV2L2, HBS1L, EXOSC9, ZCCHC8, EXOSC2, C1D, PXN, RBM7, IFI16, MED4, MED20, MED23, SNRPB, TMPO, Exosc1, DUSP13, BRCA1, RXRB, ESR2, EZH2, SUZ12, RECQL4, DCAF13, ABCC6, nsp8, NFX1, TRIM28, USP2, LNX1, PIAS2, POLDIP3, RASD1, RFC5, NEDD9, SNAI1, LSM4, HAPLN2, PHF21A, SLAIN1, LMO4, DDIT4L, FAM161B, WDYHV1, SPATC1L, RUSC1, RPP14, GEM, CNNM3, HOXB9, MYOZ1, C5orf30, FOXD4L1, KCNJ11, INCA1, KANK2, C22orf39, SOCS7, LOC100507462, PLEKHA4, ZC3H18, CABLES1, ESR1, PRC1, nsp8ab, nsp2ab, DNAJC4, THOP1, EIF4E2, GIGYF2, nsp2, UFL1, DDRGK1, HIST1H2BG, TERF2IP, PRPF6, RPL3, RBM22, PKP2, SNRPN, SF1, CPSF7, ERAL1, ANKHD1, RPS28, SFPQ, FYTTD1, MRPL2, SLIRP, C1orf131, UTP14A, SUGP2, UNKL, SGOL2, TFIP11, SARNP, PRPF31, TBRG1, ILF2, PRR3, CCL14, SNW1, LENG1, METTL14, CCSER2, SRPK2, SNRPA, PACSIN2, SRSF10, RBBP4, RPLP0, Ube2i, Rbm14, Dusp14, Hnrnpk, Grb2, Mbp, Gltscr2, Canx, Eif3d, Pspc1, Elavl4, Cpeb4, Zcchc17, Pabpc1, Mrpl13,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EXOSC8	chr13	37574478	T	C	single_nucleotide_variant	Benign	not_provided
EXOSC8	chr13	37574481	CA	C	Deletion	Benign	not_provided
EXOSC8	chr13	37574481	CAA	C	Deletion	Benign	not_provided
EXOSC8	chr13	37574681	C	T	single_nucleotide_variant	Benign	not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
EXOSC8	chr13	37574708	G	A	single_nucleotide_variant	Benign	not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
EXOSC8	chr13	37574714	C	T	single_nucleotide_variant	Benign	not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
EXOSC8	chr13	37574944	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
EXOSC8	chr13	37574947	C	T	single_nucleotide_variant	Pathogenic	Pontocerebellar_hypoplasia,_type_1c	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EXOSC8	chr13	37574951	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EXOSC8	chr13	37574953	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EXOSC8	chr13	37574955	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Pontocerebellar_hypoplasia,_type_1c\|not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EXOSC8	chr13	37574960	G	T	single_nucleotide_variant	Uncertain_significance	Pontocerebellar_hypoplasia,_type_1c	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
EXOSC8	chr13	37574967	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37576612	CAT	C	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37576656	TTGG	T	Deletion	Uncertain_significance	not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
EXOSC8	chr13	37576695	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37578570	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37579999	C	CA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37580087	C	G	single_nucleotide_variant	Pathogenic	Spastic_ataxia	SO:0001587\|nonsense	SO:0001587\|nonsense
EXOSC8	chr13	37580090	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EXOSC8	chr13	37580139	G	A	single_nucleotide_variant	Benign	Pontocerebellar_hypoplasia,_type_1c\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EXOSC8	chr13	37580302	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37581051	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37581103	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37581105	A	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37581147	C	T	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EXOSC8	chr13	37581153	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EXOSC8	chr13	37581180	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EXOSC8	chr13	37581192	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EXOSC8	chr13	37581195	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EXOSC8	chr13	37582406	GACC	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37582863	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EXOSC8	chr13	37582884	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EXOSC8	chr13	37582952	T	C	single_nucleotide_variant	Uncertain_significance	Pontocerebellar_hypoplasia,_type_1c	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EXOSC8	chr13	37583337	T	TG	Duplication	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
EXOSC8	chr13	37583386	G	T	single_nucleotide_variant	Uncertain_significance	Pontocerebellar_hypoplasia,_type_1c	SO:0001587\|nonsense	SO:0001587\|nonsense
EXOSC8	chr13	37583413	A	T	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EXOSC8	chr13	37583420	G	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Pontocerebellar_hypoplasia,_type_1c\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EXOSC8	ESCA	chr13	37580070	37580070	T	A	Missense_Mutation	p.D84E	3
EXOSC8	STAD	chr13	37581201	37581201	A	-	Frame_Shift_Del	p.L160X	3
EXOSC8	PAAD	chr13	37582916	37582916	G	T	Missense_Mutation	p.G220V	3
EXOSC8	STAD	chr13	37581201	37581201	A	-	Frame_Shift_Del	p.L160fs	3
EXOSC8	KIRP	chr13	37583387	37583387	A	G	Missense_Mutation	p.E261G	3
EXOSC8	UCEC	chr13	37582255	37582255	G	T	Missense_Mutation	p.K183N	2
EXOSC8	SKCM	chr13	37582930	37582930	G	C	Missense_Mutation	p.V225L	2
EXOSC8	SKCM	chr13	37581124	37581124	C	T	Silent	p.L135L	2
EXOSC8	ESCA	chr13	37580070	37580070	T	A	Missense_Mutation		2
EXOSC8	PAAD	chr13	37582916	37582916	G	T	Missense_Mutation		2
EXOSC8	STAD	chr13	37577117	37577117	T	A	Missense_Mutation	p.N55K	2
EXOSC8	STAD	chr13	37582924	37582924	A	C	Missense_Mutation	p.T223P	2
EXOSC8	COAD	chr13	37582955	37582955	G	A	Missense_Mutation	p.C233Y	1
EXOSC8	THYM	chr13	37582896	37582896	G	T	Missense_Mutation	p.E213D	1
EXOSC8	KIRP	chr13	37583387	37583387	A	G	Missense_Mutation		1
EXOSC8	SARC	chr13	37580294	37580294	A	-	Frame_Shift_Del		1
EXOSC8	COAD	chr13	37583365	37583365	C	T	Nonsense_Mutation	p.R254X	1
EXOSC8	KIRP	chr13	37576688	37576688	G	T	Missense_Mutation		1
EXOSC8	SARC	chr13	37580294	37580294	A	-	Frame_Shift_Del	p.G129fs	1
EXOSC8	DLBC	chr13	37577073	37577073	T	C	Missense_Mutation	p.S41P	1
EXOSC8	LIHC	chr13	37583329	37583329	G	T	Missense_Mutation		1
EXOSC8	ACC	chr13	37582275	37582275	G	T	Missense_Mutation	p.R190I	1
EXOSC8	SARC	chr13	37580294	37580294	A	-	Frame_Shift_Del	p.K130fs	1
EXOSC8	ESCA	chr13	37576435	37576437	AGG	-	In_Frame_Del	p.R16in_frame_del	1
EXOSC8	LIHC	chr13	37580077	37580077	C	-	Frame_Shift_Del	p.P87fs	1
EXOSC8	BLCA	chr13	37582296	37582296	C	T	Missense_Mutation		1
EXOSC8	LUAD	chr13	37583435	37583435	A	T	Nonstop_Mutation	p.*277L	1
EXOSC8	BLCA	chr13	37580265	37580265	C	T	Nonsense_Mutation	p.Q120*	1
EXOSC8	PAAD	chr13	37576427	37576427	A	G	Missense_Mutation		1
EXOSC8	BLCA	chr13	37580265	37580265	C	G	Missense_Mutation	p.Q120E	1
EXOSC8	ESCA	chr13	37578662	37578662	G	A	Missense_Mutation	p.A68T	1
EXOSC8	BLCA	chr13	37582296	37582296	C	T	Missense_Mutation	p.S197F	1
EXOSC8	STAD	chr13	37583392	37583392	A	-	Frame_Shift_Del	p.V262fs	1
EXOSC8	ESCA	chr13	37576435	37576437	AGG	-	In_Frame_Del	p.R16del	1
EXOSC8	CESC	chr13	37580139	37580139	G	A	Silent		1
EXOSC8	GBM	chr13	37580266	37580266	A	C	Missense_Mutation	p.Q120P	1
EXOSC8	PAAD	chr13	37576427	37576427	A	G	Missense_Mutation	p.E12G	1
EXOSC8	CESC	chr13	37574722	37574722	C	G	Missense_Mutation		1
EXOSC8	HNSC	chr13	37578686	37578686	A	-	Frame_Shift_Del	p.K76fs	1
EXOSC8	READ	chr13	37576630	37576630	G	T	Missense_Mutation	p.E20D	1
EXOSC8	COAD	chr13	37582284	37582284	C	T	Missense_Mutation	p.P193L	1
EXOSC8	READ	chr13	37578694	37578694	C	T	Silent	p.Y78Y	1

Copy number variation (CNV) of EXOSC8
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EXOSC8
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
88131	BRCA	TCGA-A2-A0CW-01A	CAB39L	chr13	49918315	-	EXOSC8	chr13	37576625	+
88131	STAD	TCGA-HU-A4GN-01A	CENPJ	chr13	25466781	-	EXOSC8	chr13	37583321	+
87754	BRCA	TCGA-C8-A1HE	EXOSC8	chr13	37574959	+	NDUFS1	chr2	206997829	-
88134	N/A	FN108538	SUPT20H	chr13	37583453	-	EXOSC8	chr13	37583451	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	EXOSC8	0.0241157732484417	0.68
TGCT	EXOSC8	0.0320226632988147	0.86
KIRP	EXOSC8	0.0344569754346707	0.9

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	EXOSC8	0.0164977003533587	0.49
LUAD	EXOSC8	0.0400000292150107	1
BRCA	EXOSC8	0.00630180866480257	0.2
PAAD	EXOSC8	0.000358104542757223	0.012
THYM	EXOSC8	0.00453575725750094	0.15

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C4015160	PONTOCEREBELLAR HYPOPLASIA, TYPE 1C	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
C1843504	Pontocerebellar Hypoplasia Type 1	1	ORPHANET