|
||||||
|
Translation Factor: TENT5B (NCBI Gene ID:115572) |
|
 Gene Summary |
| Gene Information | Gene Name: TENT5B | Gene ID: 115572 | Gene Symbol | TENT5B | Gene ID | 115572 |
| Gene Name | terminal nucleotidyltransferase 5B | |
| Synonyms | FAM46B | |
| Cytomap | 1p36.11 | |
| Type of Gene | protein-coding | |
| Description | terminal nucleotidyltransferase 5Bfamily with sequence similarity 46 member Bprotein FAM46Bputative nucleotidyltransferase FAM46B | |
| Modification date | 20200313 | |
| UniProtAcc | Q96A09 | |
| Child GO biological process term(s) under GO:0006412 |
| GO ID | GO term |
| GO:0006417 | Regulation of translation |
| GO:0045727 | Positive regulation of translation |
| GO:0006412 | Translation |
| Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Inferred gene age of translation factor. |
| Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
| TENT5B | (733 - 1119.25] |
Top |
|
| We searched PubMed using 'TENT5B[title] AND translation [title] AND human.' |
| Gene | Title | PMID |
| TENT5B | . | . |
Top |
|
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
 |
| Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
| Exon skipping position in the amino acid sequence. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
| Potentially (partially) lost protein functional features of UniProt. |
| UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
Top |
|
| Gene expression level across TCGA pancancer |
 |
| Gene expression level across GTEx pantissue |
 |
| Expression level of gene isoforms across TCGA pancancer |
 |
| Expression level of gene isoforms across GTEx pantissue |
 |
| Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
| Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
| Cancer type | Translation factor | FC | adj.pval |
Top |
|
| Translation factor expression regulation through miRNA binding |
| Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
| Translation factor expression regulation through methylation in the promoter of Translation factor |
| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through copy number variation of Translation factor |
| Cancer type | Gene | Coefficient | Pvalue |
Top |
|
| Strongly correlated genes belong to cellular important gene groups with TENT5B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
| Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
Top |
|
| Protein 3D structure Visit iCn3D. |
Top |
|
| Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
 |
| Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
 |
 * Edge colors based on TCGA cancer types. |
| * Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
 |
| Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
| KIRP | TENT5B | FAM43B | -5.94279053603497 | 0.000213860534131527 |
| THCA | TENT5B | ATXN1 | -2.03015234605884 | 0.000278681868396263 |
| STAD | TENT5B | MTPAP | -6.52882003332551 | 0.000280400272458792 |
| STAD | TENT5B | FAM46B | -3.55220624497826 | 0.000471815001219511 |
| LUSC | TENT5B | ATXN1 | -1.44094546165647 | 0.000561719865669169 |
| COAD | TENT5B | FAM43B | 3.01704386470603 | 0.000934779644012452 |
| PRAD | TENT5B | RBM43 | -1.73905772850352 | 0.00170492480464144 |
| KICH | TENT5B | FAM46B | -2.53364527931826 | 0.00308787822723389 |
| THCA | TENT5B | FAM117B | -1.47152751367836 | 0.00361724055434455 |
| STAD | TENT5B | ITPRIPL2 | 1.25638130157777 | 0.0139979305677116 |
| PRAD | TENT5B | ATXN1 | -1.25701607945672 | 0.0209655998648434 |
| LUSC | TENT5B | ITPRIPL1 | 1.41454890303687 | 0.0230222200996548 |
| ESCA | TENT5B | FAM43B | 2.85656264920442 | 0.0244140625 |
| CHOL | TENT5B | FAM46B | -1.00591120026069 | 0.02734375 |
| LUAD | TENT5B | FAM117B | -2.0873289664058 | 0.0290106239426232 |
| HNSC | TENT5B | ITPRIPL2 | 1.22649469718394 | 0.0310955134514188 |
| PRAD | TENT5B | FAM46B | -1.69236004381194 | 1.02073776774091e-07 |
| THCA | TENT5B | ITPRIPL2 | -2.83367384165457 | 1.17810920709243e-05 |
| PRAD | TENT5B | FAM117B | 1.34793112989379 | 1.18579474403006e-07 |
| KIRC | TENT5B | ITPRIPL1 | -3.64029355322834 | 1.44148329893084e-11 |
| THCA | TENT5B | C2orf54 | -1.04173258926989 | 1.80531355255887e-07 |
| THCA | TENT5B | FAM46B | -3.79386094916147 | 2.95658508868706e-08 |
| LUSC | TENT5B | C2orf54 | -1.39281438475901 | 3.83345670300892e-09 |
| LUAD | TENT5B | FAM46B | -3.60794598676294 | 4.21032885135405e-11 |
| LUSC | TENT5B | FAM46B | -1.76157139012434 | 5.01801310796711e-08 |
| KICH | TENT5B | FAM43B | -2.59882090248096 | 5.24520874023437e-06 |
| LUAD | TENT5B | MTPAP | -2.75643668768724 | 5.24732369463512e-07 |
| HNSC | TENT5B | C2orf54 | -1.32074469640941 | 5.60316948394758e-09 |
| Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
| PPI interactors with TENT5B |
Top |
|
| Clinically associated variants from ClinVar. |
| Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
| nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
| SNVs and Indels |
| Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
| Copy number variation (CNV) of TENT5B * Click on the image to open the original image in a new window. |
 |
| Fusion gene breakpoints (product of the structural variants (SVs)) across TENT5B * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion genes with this translation factor from FusionGDB2.0. |
| FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Top |
|
| Kaplan-Meier plots with logrank tests of overall survival (OS) |
| Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
Top |
|
| Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
| Cancer type | Translation factor | pval | adj.p |
Top |
|
| Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
| Cancer type | Translation factor | pval | adj.p |
Top |
|
| Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
|
| Diseases associated with this translation factor. (DisGeNet 4.0) |
| Disease ID | Disease Name | # PubMeds | Disease source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies