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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL10 (NCBI Gene ID:124995)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL10
	Gene ID: 124995
	Gene Symbol	MRPL10
	Gene ID	124995
	Gene Name	mitochondrial ribosomal protein L10
	Synonyms	L10MT\|MRP-L10\|MRP-L8\|MRPL8\|RPML8
	Cytomap	17q21.32
	Type of Gene	protein-coding
	Description	39S ribosomal protein L10, mitochondrial39S ribosomal protein L8, mitochondrialL8mtmitochondrial large ribosomal subunit protein uL10m
	Modification date	20200313
	UniProtAcc	Q7Z7H8

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL10[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL10	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000351111	45904002	45904147	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	MRPL10	-3.22703617995931	0.000209845686767642
STAD	MRPL10	-4.87461667395871	0.0118026207201183
LUSC	MRPL10	-2.440715746941	1.79996309233889e-05
LUAD	MRPL10	-5.60579373211551	4.11637918366747e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL10 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	MRPL10	NME2	0.812294162	1.26E-11
CHOL	TF	MRPL10	NME2	0.812294162	1.26E-11
TGCT	TSG	MRPL10	PHB	0.829650922	8.00E-41

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	MRPL10	MRPL53	-7.51258875763857	0.000291380503797954
KIRC	MRPL10	MRPL55	-1.02163441832258	0.000291940846845375
KIRC	MRPL10	MRPL11	-1.04966837625557	0.000354478033746394
LIHC	MRPL10	MRPL13	1.54402472107614	0.000655351190157038
LUSC	MRPL10	MRPL39	-3.50411737429004	0.000985010025625636
CHOL	MRPL10	MRPL3	-2.68429255990621	0.00390625
BLCA	MRPL10	MRPL39	1.69896851960452	0.00391769409179688
LUAD	MRPL10	MRPL39	-1.1049452981592	0.00471395891927286
ESCA	MRPL10	MRPL3	-4.97897094908275	0.0048828125
LUAD	MRPL10	MRPL53	-2.94709001291011	0.00627510264512955
ESCA	MRPL10	MRPL13	-1.07746088474995	0.0068359375
PRAD	MRPL10	ICT1	-1.54848444909352	0.00907723161841939
ESCA	MRPL10	MRPL12	-1.00174970895481	0.009765625
CHOL	MRPL10	MRPL12	-3.63130566135659	0.01171875
STAD	MRPL10	MRPL12	-2.48538214070711	0.020511694252491
STAD	MRPL10	MRPL4	1.4393539135682	0.0279771662317216
COAD	MRPL10	MRPL39	-1.15285953291756	0.0357243716716767
STAD	MRPL10	MRPL53	1.66304360300706	0.0413399673998356
BLCA	MRPL10	MRPL22	-2.25969747792543	0.0493659973144531
BRCA	MRPL10	MRPL22	-2.3061823226724	1.15724909394453e-08
PRAD	MRPL10	MRPL11	1.12581653394628	1.15996224044503e-05
LUAD	MRPL10	MRPL12	-3.43280900900763	1.96929418449732e-09
KIRC	MRPL10	MRPL3	1.69955762234244	1.97132191719422e-08
BRCA	MRPL10	ICT1	-4.17488220449664	2.73719348917167e-14
COAD	MRPL10	MRPL4	2.77705897514473	2.98023223876954e-07
LIHC	MRPL10	MRPL39	-1.65461683386216	3.95799979560965e-08
BRCA	MRPL10	MRPL55	-1.64092910603924	6.01408870059924e-14
LUSC	MRPL10	ICT1	-3.23093376049456	6.60526357089358e-07
LUAD	MRPL10	MRPL22	-3.64343361732659	6.84976461567817e-06
LUSC	MRPL10	MRPL55	-1.42665529836846	7.19742900589893e-05
LUAD	MRPL10	MRPL55	-2.50406829694459	7.3663238952828e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL10

USP22, ICT1, APP, MRPL12, MRPL15, MRPL3, MRPL13, MRPL1, MRPL11, MRPL41, MRPL23, ILF3, ABCB7, SLC25A3, ABCC2, HNRNPU, BCS1L, NPM1, REL, TCF4, PNMA1, KLHL12, FAM9B, EGFR, RPS8, MRPL4, HNRNPA1, MRPL39, MRPS30, MRPL47, MRPL22, MRPL50, MRPL9, ACTN2, MRPL42, MRPL45, MRPL2, MRPL51, MRPL55, MRPL44, MRPL34, MRPL30, MRPL49, MRPL32, MRPL16, MRPL27, MRPL17, MRPL40, MRPL28, MRPL48, MRPL38, GADD45GIP1, MRPL24, MRPS18A, MRPL33, MRPL35, MRPL19, MRPL46, MRPL20, MALSU1, MRPL43, MRPL57, MRPL18, UQCC1, MRPL53, MRPL21, MRPL14, ZZEF1, C4BPB, FGF8, RPL36AL, PREPL, LEO1, MRPL36, MRPS11, MRPS14, MRPS5, GATB, PGK1, PSMD12, TAZ, WDR61, ZNF830, ESR2, LARP7, RECQL4, SERBP1, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, VCP, RC3H2, SNRNP70, Dppa3, PRKCI, RASA1, IMMP2L, GRSF1, ARHGAP31, ECT2L, ACAD9, AUH, C12orf65, C1QBP, C21orf33, C6orf203, CS, GFM1, GFM2, HINT2, LRPPRC, MDH2, METTL15, METTL17, MRPS12, MRPS26, MRRF, MTERF3, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, SLIRP, TACO1, TBRG4, TFAM, TRUB2, TSFM, TUFM, VWA8, EXD2, CLPP, Apc2, NR3C1, HSCB, UFL1, DDRGK1, AARS2, COX8A, PDHA1, SRSF3, ZNF483, RBMS2, LIN28A, YBX2, RPL13, RPL37, RPL19, YBX1, RPL6, H1FNT, MRPL52, RPL10, YARS2, HERC2, HIST1H2AE, RNMTL1, MRPL37, KLHL22, NEURL4, NEIL1, LONP1, RBPMS, Pcbp1, M, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL10	KIRP	chr17	45901623	45901623	G	A	Missense_Mutation	p.S255F	4
MRPL10	LIHC	chr17	45906024	45906024	G	A	Missense_Mutation	p.T32I	3
MRPL10	SKCM	chr17	45901815	45901815	A	G	Missense_Mutation	p.I191T	2
MRPL10	SKCM	chr17	45904462	45904462	G	A	Missense_Mutation	p.L121F	2
MRPL10	UCEC	chr17	45901589	45901589	G	A	Silent	p.D256	2
MRPL10	UCEC	chr17	45904012	45904012	G	A	Missense_Mutation	p.P175S	2
MRPL10	PAAD	chr17	45904115	45904115	G	A	Silent		2
MRPL10	UCEC	chr17	45905949	45905949	A	C	Missense_Mutation	p.L47R	2
MRPL10	LUAD	chr17	45901636	45901636	G	A	Missense_Mutation	p.R251C	2
MRPL10	PAAD	chr17	45904115	45904115	G	A	Silent	p.Y150Y	2
MRPL10	UCEC	chr17	45905968	45905968	G	A	Missense_Mutation	p.H41Y	2
MRPL10	HNSC	chr17	45901757	45901757	C	T	Silent	p.L210L	2
MRPL10	BLCA	chr17	45901597	45901597	C	A	Missense_Mutation		1
MRPL10	LUAD	chr17	45901816	45901816	T	C	Missense_Mutation	p.I191V	1
MRPL10	COAD	chr17	45904067	45904067	A	G	Silent	p.S166S	1
MRPL10	SARC	chr17	45901681	45901681	G	A	Missense_Mutation		1
MRPL10	KIRP	chr17	45901623	45901623	G	A	Missense_Mutation		1
MRPL10	THCA	chr17	45904011	45904011	G	A	Missense_Mutation		1
MRPL10	BLCA	chr17	45901604	45901604	C	T	Silent		1
MRPL10	LUAD	chr17	45901636	45901636	G	A	Missense_Mutation	p.R241C	1
MRPL10	COAD	chr17	45904420	45904420	C	T	Missense_Mutation	p.V135I	1
MRPL10	LGG	chr17	45904016	45904016	G	T	Missense_Mutation	p.F183L	1
MRPL10	THCA	chr17	45904011	45904011	G	A	Missense_Mutation	p.P185L	1
MRPL10	BLCA	chr17	45904438	45904438	G	A	Missense_Mutation		1
MRPL10	LUAD	chr17	45904472	45904472	C	A	Missense_Mutation	p.E107D	1
MRPL10	ESCA	chr17	45906019	45906019	G	T	Missense_Mutation	p.Q24K	1
MRPL10	LGG	chr17	45904016	45904016	G	T	Missense_Mutation		1
MRPL10	UCEC	chr17	45905949	45905949	A	C	Missense_Mutation	p.L57R	1
MRPL10	BLCA	chr17	45904544	45904544	G	A	Silent	p.R93R	1
MRPL10	LUAD	chr17	45901816	45901816	T	C	Missense_Mutation	p.I181V	1
MRPL10	ESCA	chr17	45904115	45904115	G	T	Nonsense_Mutation	p.Y140*	1
MRPL10	SKCM	chr17	45904422	45904422	T	C	Missense_Mutation	p.K134R	1
MRPL10	LIHC	chr17	45905967	45905967	T	C	Missense_Mutation		1
MRPL10	UCEC	chr17	45905968	45905968	G	A	Missense_Mutation	p.H51Y	1
MRPL10	BLCA	chr17	45901691	45901691	G	C	Silent	p.L232L	1
MRPL10	LUSC	chr17	45901685	45901685	G	T	Missense_Mutation	p.H234Q	1
MRPL10	ESCA	chr17	45906019	45906019	G	T	Missense_Mutation		1
MRPL10	SKCM	chr17	45904553	45904553	C	T	Silent	p.R90R	1
MRPL10	UCEC	chr17	45901635	45901635	C	T	Missense_Mutation	p.R251H	1
MRPL10	BLCA	chr17	45901604	45901604	C	T	Silent	p.G261G	1
MRPL10	OV	chr17	45904417	45904417	A	G	Missense_Mutation	p.F136L	1
MRPL10	ESCA	chr17	45904115	45904115	G	T	Nonsense_Mutation	p.Y150X	1
MRPL10	STAD	chr17	45904545	45904545	C	T	Missense_Mutation	p.R93H	1
MRPL10	LIHC	chr17	45904088	45904088	C	-	Frame_Shift_Del	p.G159fs	1
MRPL10	OV	chr17	43260921	43260921	G	C	Missense_Mutation	p.P56R	1
MRPL10	BLCA	chr17	45901597	45901597	C	A	Missense_Mutation	p.D264Y	1
MRPL10	GBM	chr17	45905957	45905957	C	T	Silent	p.R54R	1
MRPL10	STAD	chr17	45906036	45906036	C	T	Missense_Mutation	p.G28D	1
MRPL10	LUAD	chr17	45904481	45904481	C	G	Silent	p.L114L	1
MRPL10	BLCA	chr17	45904438	45904438	G	A	Missense_Mutation	p.H129Y	1
MRPL10	HNSC	chr17	45901757	45901757	C	T	Silent		1
MRPL10	STAD	chr17	45904455	45904455	C	T	Missense_Mutation	p.R123Q	1
MRPL10	BLCA	chr17	45901691	45901691	G	C	Silent	p.L222L	1
MRPL10	STAD	chr17	45904545	45904545	C	T	Missense_Mutation	p.R83H	1
MRPL10	BLCA	chr17	45904544	45904544	G	A	Silent		1
MRPL10	LUAD	chr17	45904472	45904472	C	A	Missense_Mutation	p.E117D	1
MRPL10	CESC	chr17	45901633	45901633	C	T	Missense_Mutation		1
MRPL10	PAAD	chr17	45904115	45904115	G	A	Silent	p.Y140Y	1
MRPL10	HNSC	chr17	45901757	45901757	C	T	Silent	p.L200L	1
MRPL10	STAD	chr17	45904542	45904542	C	T	Missense_Mutation	p.R84Q	1
MRPL10	BLCA	chr17	45901691	45901691	G	C	Silent		1
MRPL10	LUAD	chr17	45904124	45904124	A	G	Silent	p.D147D	1
MRPL10	CESC	chr17	45908804	45908804	G	A	Missense_Mutation	p.S25L	1
MRPL10	PRAD	chr17	45901638	45901638	T	A	Missense_Mutation	p.Q250L	1
MRPL10	STAD	chr17	45904455	45904455	C	T	Missense_Mutation	p.R113Q	1

Copy number variation (CNV) of MRPL10
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL10
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
89826	BLCA	TCGA-HQ-A2OF-01A	MRPL10	chr17	45904003	-	MTPAP	chr10	30611546	-
87218	N/A	CS190707	MRPL10	chr17	45905895	+	PDSS2	chr6	107679553	+
89357	N/A	ES316348	MRPL10	chr17	45900877	-	PLP1	chrX	103045970	+
92287	UCEC	TCGA-AJ-A23N-01A	MRPL10	chr17	45904003	-	SKAP1	chr17	46266862	-
76259	N/A	BE265135	RPL23	chr17	37006343	-	MRPL10	chr17	45908870	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	MRPL10	0.00161752749424953	0.044
LIHC	MRPL10	0.00644981348883298	0.17
BRCA	MRPL10	0.0455376782275547	1
SARC	MRPL10	2.09119174675967e-06	5.9e-05

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPL10	0.0163103790821265	0.52
THCA	MRPL10	0.0131717287164619	0.43
KIRP	MRPL10	0.0494966326408977	1
BRCA	MRPL10	0.048908132131617	1
CHOL	MRPL10	0.0209279920616939	0.65

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source