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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: MTPN (NCBI Gene ID:136319)


Gene Summary

check button Gene Summary
Gene InformationGene Name: MTPN
Gene ID: 136319
Gene Symbol

MTPN

Gene ID

136319

Gene Namemyotrophin
SynonymsGCDP|V-1
Cytomap

7q33

Type of Geneprotein-coding
Descriptionmyotrophingranule cell differentiation proteinprotein V-1
Modification date20200313
UniProtAcc

P58546


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTPN

GO:0008361

regulation of cell size

10329199

HgeneMTPN

GO:2000812

regulation of barbed-end actin filament capping

16895918



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MTPN(733 - 1119.25]


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Translation Studies in PubMed

check button We searched PubMed using 'MTPN[title] AND translation [title] AND human.'
GeneTitlePMID
MTPN.


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST00000393085135635346135635430In-frame

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST0000039308513563534613563543037554034861186290

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
P5854662902118ChainID=PRO_0000067031;Note=Myotrophin
P5854662903466RepeatNote=ANK 2
P5854662906799RepeatNote=ANK 3
P5854662907178HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AAA
P5854662908189HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AAA


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
Cancer typeTranslation factorFCadj.pval


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
Cancer typeGeneCoefficientPvalue

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with MTPN (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
LUADMTPNTMOD41.633009418315940.00013655479316203
BRCAMTPNTMOD41.920824087659790.000142811665900358
STADMTPNENOPH1-1.660972956388030.000234263017773628
HNSCMTPNADD2-3.083844079579240.000758805770146865
BLCAMTPNENOPH1-1.750405818365940.00141143798828125
HNSCMTPNTMOD4-1.204213678505140.00343508452415636
CHOLMTPNENOPH1-1.808902659322860.00390625
KIRPMTPNEEF1B2-1.625687482514490.00571200484409928
PRADMTPNFAM60A-1.371505538042240.00655955789452538
LUSCMTPNADD22.756325515559560.0103579966452505
PRADMTPNGRK6-2.196292459575890.0109157868561552
STADMTPNADD21.220057385505520.0132303284481168
KICHMTPNEEF1B21.731278613658180.0135546922683716
KICHMTPNADD1-2.162908046556030.0173123478889465
ESCAMTPNENOPH1-2.628751971591350.0244140625
STADMTPNGRK61.524730418123140.0358188794925809
CHOLMTPNADD1-2.292564888524490.0390625
UCECMTPNENOPH1-6.385982231499280.046875
PRADMTPNADD1-1.150386899095881.12934832314652e-06
THCAMTPNFAM60A-1.541382023083251.23726554130083e-06
LIHCMTPNGRK6-1.922194723643721.3228314710996e-06
COADMTPNADD21.182456604845851.33216381072998e-05
BRCAMTPNDMAP11.273311695833751.6127659552001e-07
KIRCMTPNADD2-1.697489463255831.88617492161823e-09
KIRPMTPNGRK6-1.476840591675652.0815059542656e-07
KIRPMTPNADD2-1.463544162091154.5965425670147e-06
COADMTPNDMAP11.690722762692829.14931297302247e-06


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with MTPN
DSTYK, RELA, NFKB1, REL, MAPK1, ELAVL1, NPLOC4, ATP6V1A, MTAP, OXCT1, PDIA3, PTPN11, RAB1A, RBBP4, DPY30, GARS, NUP93, PIP4K2A, PIP4K2C, UBA1, CEP170, CEP290, CNTROB, SPICE1, CEP135, CEP164, CNTRL, DCTN1, SASS6, TMEM237, MCM2, OTUB1, ZNF131, SOD1, HHV8GK18_gp78, TRIM14, AAR2, PIH1D1, AGR2, FXN, LAP3, LACTB2, PMPCA, CRYZ, COX4I1, CLIC4, ALDH4A1, GLRX5, MSRB3, GUK1, COA7, MPST, ANXA1, C21orf33, HADH, DGUOK, GSTP1, PRDX6, SPR, AK2, AK4, HINT1, GIMAP8, ISCA2, RAB11FIP5, PSAP, TXN, TXNDC12, ORF3a, E, KIF14, ARHGAP11B, ARHGAP35, HNRNPH1, DNAJA3, DNAJB5, DNAJC4, TRIM24, ARHGDIA, MDH1, TBCA, DDTL, CYCS, CSTB, RPS28, DDX58, PMAIP1, HTRA4, NAA40, MSH3, GLDC, MCTS1, METTL2B, HMCES, ADSL, PLCG1, PALLD, CTH, DDX59, FAM188A, ZC3HAV1L, IKBKG, IBA57, MPP2, FAM49B, FTO, EFHD2, UBLCP1, RECQL, C12orf5, GMPS, HDHD3, FARSB, PLS1, LRRC40, BOLA3, DIS3, ACSF3, PTER, CAPZA2, CAPZB, CASP6, SHC1, SCLY, GNB1L, KLHL42, DNPEP, SNX27, THNSL1, CMAS, PBK, PNPO, FAM120B, NADK2, DNAJC2, HNRNPLL, LANCL2, NT5C3B,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
MTPNSTADchr7135614721135614721CTMissense_Mutationp.A104T4
MTPNSKCMchr7135636300135636300GASilentp.L51L2
MTPNUCECchr7135635429135635429GTMissense_Mutationp.A63D2
MTPNUCECchr7135661831135661831GTMissense_Mutationp.F6L2
MTPNCOADchr7135635388135635388ACMissense_Mutationp.Y77D1
MTPNLUSCchr7135661836135661836CGMissense_Mutationp.E5Q1
MTPNHNSCchr7135635385135635385CTMissense_Mutation1
MTPNHNSCchr7135635385135635385CTMissense_Mutationp.E78K1
MTPNSKCMchr7135614697135614697CGMissense_Mutationp.A112P1
MTPNLGGchr7135614721135614721CAMissense_Mutationp.A104S1
MTPNSKCMchr7135636343135636343CTSilentp.R36R1
MTPNLIHCchr7135614722135614722G-Frame_Shift_Del1
MTPNLIHCchr7135661814135661814T-Frame_Shift_Delp.N12fs1
MTPNSTADchr7135636279135636280-TFrame_Shift_Insp.G58fs1
MTPNBLCAchr7135635365135635365CTSilent1
MTPNLIHCchr7135635362135635362T-Frame_Shift_Delp.K85fs1
MTPNSTADchr7135636280135636281-TFrame_Shift_Insp.K57fs1
MTPNBLCAchr7135614740135614740TCSilent1
MTPNLIHCchr7135635373135635373A-Frame_Shift_Delp.S82fs1
MTPNTGCTchr7135635404135635404AGSilent1
MTPNBLCAchr7135661868135661868GAMissense_Mutation1
MTPNLIHCchr7135612387135612387TCMissense_Mutation1
MTPNBLCAchr7135635365135635365CTSilentp.V84V1
MTPNLIHCchr7135612338135612338AGMissense_Mutation1
MTPNCOADchr7135614713135614713TCSilentp.E106E1
MTPNLUADchr7135614761135614761CASplice_Site1

check buttonCopy number variation (CNV) of MTPN
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across MTPN
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
71282STADTCGA-HU-8238-01ABAIAP2L1chr798030114-MTPNchr7135636378-
71282N/ACB149514CFL1chr1165623142-MTPNchr7135612472-
71282N/AAW608046LUZP6chr7135612612+MTPNchr7135612614+
71282N/AAW608050LUZP6chr7135612656+MTPNchr7135612658+
71282N/AAW608053LUZP6chr7135612618+MTPNchr7135612620+
79571N/ABQ325609MTPNchr7135613459+CA12chr1563617364-
95456N/AAW580203MTPNchr7135612098+LUZP6chr7135612100+
95456N/AAW608048MTPNchr7135612638+LUZP6chr7135612640+
95456N/AAW608054MTPNchr7135612618+LUZP6chr7135612620+
95456N/AAW608063MTPNchr7135611987+LUZP6chr7135611989+
95456N/AEC464354MTPNchr7135612701+LUZP6chr7135612704+
95456N/AEC570737MTPNchr7135612329+LUZP6chr7135612331+
71282N/ABU608013MTPNchr7135611719+MTPNchr7135611937-
71290STADTCGA-BR-A4J7-01ARAB2Achr861429812+MTPNchr7135614760-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
Cancer typeTranslation factorpvaladj.p

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
Cancer typeTranslation factorpvaladj.p

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0019193Hepatitis, Toxic1CTD_human
C1262760Hepatitis, Drug-Induced1CTD_human
C3658290Drug-Induced Acute Liver Injury1CTD_human
C4277682Chemical and Drug Induced Liver Injury1CTD_human
C4279912Chemically-Induced Liver Toxicity1CTD_human