Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RC3H1 (NCBI Gene ID:149041)

Gene Summary

Gene Summary

Gene Information	Gene Name: RC3H1
	Gene ID: 149041
	Gene Symbol	RC3H1
	Gene ID	149041
	Gene Name	ring finger and CCCH-type domains 1
	Synonyms	RNF198\|ROQUIN
	Cytomap	1q25.1
	Type of Gene	protein-coding
	Description	roquin-1RING finger and C3H zinc finger protein 1RING finger and CCCH-type zinc finger domain-containing protein 1RING finger protein 198probable E3 ubiquitin-protein ligase Roquin
	Modification date	20200313
	UniProtAcc	Q5TC82

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RC3H1	GO:0000209	protein polyubiquitination	26489670
Hgene	RC3H1	GO:0000956	nuclear-transcribed mRNA catabolic process	25026078

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RC3H1	(355.7 - 733]

Top

Translation Studies in PubMed

We searched PubMed using 'RC3H1[title] AND translation [title] AND human.'

Gene	Title	PMID
RC3H1	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000258349	173912579	173912753	In-frame
ENST00000367696	173912579	173912753	In-frame
ENST00000258349	173921123	173921276	In-frame
ENST00000367696	173921123	173921276	In-frame
ENST00000258349	173933976	173934258	In-frame
ENST00000367696	173933976	173934258	In-frame
ENST00000258349	173939642	173939755	Frame-shift
ENST00000367696	173939642	173939755	Frame-shift
ENST00000258349	173941646	173941765	Frame-shift
ENST00000367696	173941646	173941765	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000258349	173912579	173912753	11005	3041	3214	1133	987	1045
ENST00000367696	173912579	173912753	11278	3314	3487	1133	987	1045
ENST00000258349	173921123	173921276	11005	2450	2602	1133	790	841
ENST00000367696	173921123	173921276	11278	2723	2875	1133	790	841
ENST00000258349	173933976	173934258	11005	1414	1695	1133	445	538
ENST00000367696	173933976	173934258	11278	1687	1968	1133	445	538

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q5TC82	987	1045	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
Q5TC82	790	841	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
Q5TC82	445	538	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
Q5TC82	987	1045	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
Q5TC82	790	841	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
Q5TC82	445	538	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
Q5TC82	445	538	533	788	Compositional bias	Note=Pro-rich
Q5TC82	445	538	533	788	Compositional bias	Note=Pro-rich
Q5TC82	445	538	510	510	Site	Note=Cleavage%3B by MALT1;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q4VGL6
Q5TC82	445	538	510	510	Site	Note=Cleavage%3B by MALT1;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q4VGL6
Q5TC82	445	538	462	462	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q5TC82	445	538	462	462	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q5TC82	445	538	531	531	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q4VGL6
Q5TC82	445	538	531	531	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q4VGL6
Q5TC82	445	538	535	535	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q5TC82	445	538	535	535	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q5TC82	987	1045	988	996	Alternative sequence	ID=VSP_015015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q5TC82	987	1045	988	996	Alternative sequence	ID=VSP_015015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	RC3H1	-1.29991084187784	1.32301924544461e-07
HNSC	RC3H1	-4.09292724571814	1.74507063093188e-05

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
LIHC	RC3H1	hsa-miR-140-5p	74	-0.348745653996004	0.00188110737013305

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with RC3H1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Epifactor	RC3H1	POGZ	0.80140397	7.80E-12
GBM	Epifactor	RC3H1	INO80D	0.861514769	6.43E-52
THYM	Cell metabolism gene	RC3H1	SYNJ1	0.802008003	1.26E-28
THYM	Cell metabolism gene	RC3H1	PNPLA8	0.806149632	4.04E-29
THYM	CGC	RC3H1	ATR	0.808588776	2.04E-29
THYM	CGC	RC3H1	FBXO11	0.808736745	1.96E-29
THYM	Epifactor	RC3H1	ARID4B	0.801973968	1.27E-28
THYM	Epifactor	RC3H1	ARID4A	0.803247815	8.98E-29
THYM	Epifactor	RC3H1	INO80D	0.804911393	5.69E-29
THYM	Epifactor	RC3H1	JMJD1C	0.805245179	5.19E-29
THYM	Epifactor	RC3H1	ATR	0.808588776	2.04E-29
THYM	Epifactor	RC3H1	PHC3	0.815548427	2.76E-30
THYM	Epifactor	RC3H1	ZNF217	0.827075648	8.30E-32
THYM	IUPHAR	RC3H1	SYNJ1	0.802008003	1.26E-28
THYM	IUPHAR	RC3H1	JMJD1C	0.805245179	5.19E-29
THYM	IUPHAR	RC3H1	ATR	0.808588776	2.04E-29
THYM	IUPHAR	RC3H1	FBXO11	0.808736745	1.96E-29
THYM	IUPHAR	RC3H1	NR2C2	0.820996493	5.44E-31
THYM	Kinase	RC3H1	ATR	0.808588776	2.04E-29
THYM	TF	RC3H1	ZNF224	0.800727717	1.78E-28
THYM	TF	RC3H1	ZNF211	0.800909463	1.69E-28
THYM	TF	RC3H1	ZNF264	0.802768477	1.02E-28
THYM	TF	RC3H1	ZFP30	0.803495526	8.39E-29
THYM	TF	RC3H1	ZNF518A	0.804532289	6.31E-29
THYM	TF	RC3H1	ZNF234	0.805403854	4.97E-29
THYM	TF	RC3H1	RBAK	0.807605932	2.69E-29
THYM	TF	RC3H1	ZNF225	0.816025415	2.40E-30
THYM	TF	RC3H1	ZNF304	0.818241462	1.25E-30
THYM	TF	RC3H1	ZNF558	0.819161905	9.46E-31
THYM	TF	RC3H1	NR2C2	0.820996493	5.44E-31
THYM	TF	RC3H1	DMTF1	0.823921813	2.22E-31
THYM	TF	RC3H1	ZNF566	0.825820675	1.23E-31
THYM	TF	RC3H1	ZNF217	0.827075648	8.30E-32
THYM	TF	RC3H1	ZNF461	0.83347818	1.06E-32
THYM	TF	RC3H1	ZNF548	0.841191162	7.83E-34
THYM	TSG	RC3H1	RBL2	0.801554413	1.42E-28
THYM	TSG	RC3H1	ATR	0.808588776	2.04E-29
THYM	TSG	RC3H1	PHC3	0.815548427	2.76E-30
THYM	TSG	RC3H1	NR2C2	0.820996493	5.44E-31
THYM	TSG	RC3H1	KRIT1	0.822202215	3.77E-31
THYM	TSG	RC3H1	DMTF1	0.823921813	2.22E-31
UCS	Cell metabolism gene	RC3H1	SYNJ1	0.802008003	1.26E-28
UCS	Cell metabolism gene	RC3H1	PNPLA8	0.806149632	4.04E-29
UCS	CGC	RC3H1	ATR	0.808588776	2.04E-29
UCS	CGC	RC3H1	FBXO11	0.808736745	1.96E-29
UCS	Epifactor	RC3H1	ARID4B	0.801973968	1.27E-28
UCS	Epifactor	RC3H1	ARID4A	0.803247815	8.98E-29
UCS	Epifactor	RC3H1	INO80D	0.804911393	5.69E-29
UCS	Epifactor	RC3H1	JMJD1C	0.805245179	5.19E-29
UCS	Epifactor	RC3H1	ATR	0.808588776	2.04E-29
UCS	Epifactor	RC3H1	PHC3	0.815548427	2.76E-30
UCS	Epifactor	RC3H1	ZNF217	0.827075648	8.30E-32
UCS	IUPHAR	RC3H1	SYNJ1	0.802008003	1.26E-28
UCS	IUPHAR	RC3H1	JMJD1C	0.805245179	5.19E-29
UCS	IUPHAR	RC3H1	ATR	0.808588776	2.04E-29
UCS	IUPHAR	RC3H1	FBXO11	0.808736745	1.96E-29
UCS	IUPHAR	RC3H1	NR2C2	0.820996493	5.44E-31
UCS	Kinase	RC3H1	ATR	0.808588776	2.04E-29
UCS	TF	RC3H1	ZNF224	0.800727717	1.78E-28
UCS	TF	RC3H1	ZNF211	0.800909463	1.69E-28
UCS	TF	RC3H1	ZNF264	0.802768477	1.02E-28
UCS	TF	RC3H1	ZFP30	0.803495526	8.39E-29
UCS	TF	RC3H1	ZNF518A	0.804532289	6.31E-29
UCS	TF	RC3H1	ZNF234	0.805403854	4.97E-29
UCS	TF	RC3H1	RBAK	0.807605932	2.69E-29
UCS	TF	RC3H1	ZNF225	0.816025415	2.40E-30
UCS	TF	RC3H1	ZNF304	0.818241462	1.25E-30
UCS	TF	RC3H1	ZNF558	0.819161905	9.46E-31
UCS	TF	RC3H1	NR2C2	0.820996493	5.44E-31
UCS	TF	RC3H1	DMTF1	0.823921813	2.22E-31
UCS	TF	RC3H1	ZNF566	0.825820675	1.23E-31
UCS	TF	RC3H1	ZNF217	0.827075648	8.30E-32
UCS	TF	RC3H1	ZNF461	0.83347818	1.06E-32
UCS	TF	RC3H1	ZNF548	0.841191162	7.83E-34
UCS	TSG	RC3H1	RBL2	0.801554413	1.42E-28
UCS	TSG	RC3H1	ATR	0.808588776	2.04E-29
UCS	TSG	RC3H1	PHC3	0.815548427	2.76E-30
UCS	TSG	RC3H1	NR2C2	0.820996493	5.44E-31
UCS	TSG	RC3H1	KRIT1	0.822202215	3.77E-31
UCS	TSG	RC3H1	DMTF1	0.823921813	2.22E-31
UVM	Cell metabolism gene	RC3H1	TRMT11	0.800396309	5.18E-19
UVM	Cell metabolism gene	RC3H1	TNPO1	0.801606971	4.19E-19
UVM	Cell metabolism gene	RC3H1	NAMPT	0.802886976	3.34E-19
UVM	Cell metabolism gene	RC3H1	CMAS	0.804790619	2.38E-19
UVM	Cell metabolism gene	RC3H1	CNOT8	0.806002786	1.91E-19
UVM	Cell metabolism gene	RC3H1	LCLAT1	0.80742215	1.48E-19
UVM	Cell metabolism gene	RC3H1	PPP1CB	0.807498086	1.46E-19
UVM	Cell metabolism gene	RC3H1	PNPLA8	0.807983342	1.33E-19
UVM	Cell metabolism gene	RC3H1	AMY2B	0.8089345	1.12E-19
UVM	Cell metabolism gene	RC3H1	SACM1L	0.810350914	8.63E-20
UVM	Cell metabolism gene	RC3H1	SEH1L	0.812082374	6.25E-20
UVM	Cell metabolism gene	RC3H1	NUDT12	0.813072655	5.19E-20
UVM	Cell metabolism gene	RC3H1	PIKFYVE	0.813166831	5.10E-20
UVM	Cell metabolism gene	RC3H1	GPD2	0.816129659	2.90E-20
UVM	Cell metabolism gene	RC3H1	PSMD14	0.816388814	2.76E-20
UVM	Cell metabolism gene	RC3H1	BPNT1	0.818574971	1.81E-20
UVM	Cell metabolism gene	RC3H1	IDI1	0.82042638	1.26E-20
UVM	Cell metabolism gene	RC3H1	NFYB	0.821027693	1.12E-20
UVM	Cell metabolism gene	RC3H1	ALG13	0.821508806	1.02E-20
UVM	Cell metabolism gene	RC3H1	MED7	0.821561596	1.01E-20
UVM	Cell metabolism gene	RC3H1	UGGT2	0.822373449	8.56E-21
UVM	Cell metabolism gene	RC3H1	PSMA4	0.823952777	6.24E-21
UVM	Cell metabolism gene	RC3H1	HMGCS1	0.826559404	3.68E-21
UVM	Cell metabolism gene	RC3H1	DCK	0.827097852	3.29E-21
UVM	Cell metabolism gene	RC3H1	MANEA	0.827578254	2.98E-21
UVM	Cell metabolism gene	RC3H1	MED17	0.830718547	1.55E-21
UVM	Cell metabolism gene	RC3H1	SMG1	0.833710949	8.22E-22
UVM	Cell metabolism gene	RC3H1	CNOT2	0.83410503	7.55E-22
UVM	Cell metabolism gene	RC3H1	GRPEL2	0.834318432	7.21E-22
UVM	Cell metabolism gene	RC3H1	VAPA	0.838717035	2.76E-22
UVM	Cell metabolism gene	RC3H1	FBXL3	0.839736913	2.20E-22
UVM	Cell metabolism gene	RC3H1	FBXW7	0.842525724	1.17E-22
UVM	Cell metabolism gene	RC3H1	GNPDA2	0.843045512	1.04E-22
UVM	Cell metabolism gene	RC3H1	NUPL1	0.846113422	5.13E-23
UVM	Cell metabolism gene	RC3H1	NUPL2	0.84697077	4.19E-23
UVM	Cell metabolism gene	RC3H1	RANBP2	0.848508816	2.92E-23
UVM	Cell metabolism gene	RC3H1	GXYLT1	0.85021425	1.94E-23
UVM	Cell metabolism gene	RC3H1	PSMC6	0.850667127	1.74E-23
UVM	Cell metabolism gene	RC3H1	MTR	0.85261535	1.08E-23
UVM	Cell metabolism gene	RC3H1	EDEM3	0.85548712	5.33E-24
UVM	Cell metabolism gene	RC3H1	MTMR6	0.859544825	1.90E-24
UVM	Cell metabolism gene	RC3H1	MED4	0.862502625	8.79E-25
UVM	Cell metabolism gene	RC3H1	DIS3	0.8626591	8.44E-25
UVM	Cell metabolism gene	RC3H1	NUP50	0.863456101	6.83E-25
UVM	Cell metabolism gene	RC3H1	PLA2G12A	0.864091031	5.77E-25
UVM	Cell metabolism gene	RC3H1	ALG10B	0.872313169	5.95E-26
UVM	Cell metabolism gene	RC3H1	PRKAA1	0.872425473	5.76E-26
UVM	Cell metabolism gene	RC3H1	NUP107	0.874369945	3.29E-26
UVM	Cell metabolism gene	RC3H1	XPO1	0.874512849	3.16E-26
UVM	Cell metabolism gene	RC3H1	FAR1	0.878256416	1.04E-26
UVM	Cell metabolism gene	RC3H1	ETNK1	0.888946451	3.57E-28
UVM	CGC	RC3H1	PHF6	0.800540216	5.05E-19
UVM	CGC	RC3H1	ERCC4	0.800722414	4.89E-19
UVM	CGC	RC3H1	ERCC3	0.801813453	4.04E-19
UVM	CGC	RC3H1	RAD21	0.808168766	1.29E-19
UVM	CGC	RC3H1	HSP90AA1	0.810288169	8.73E-20
UVM	CGC	RC3H1	HNRNPA2B1	0.811472764	7.00E-20
UVM	CGC	RC3H1	FIP1L1	0.814916734	3.66E-20
UVM	CGC	RC3H1	TRIM24	0.815359587	3.36E-20
UVM	CGC	RC3H1	SS18L1	0.816024487	2.96E-20
UVM	CGC	RC3H1	CDKN1B	0.816334809	2.79E-20
UVM	CGC	RC3H1	PSIP1	0.816859518	2.52E-20
UVM	CGC	RC3H1	APC	0.819779703	1.43E-20
UVM	CGC	RC3H1	MALT1	0.820520849	1.24E-20
UVM	CGC	RC3H1	RABEP1	0.821999618	9.22E-21
UVM	CGC	RC3H1	ACVR2A	0.823678714	6.59E-21
UVM	CGC	RC3H1	HOOK3	0.827606768	2.96E-21
UVM	CGC	RC3H1	POT1	0.827913182	2.78E-21
UVM	CGC	RC3H1	RAD17	0.829630469	1.95E-21
UVM	CGC	RC3H1	CDC73	0.83490203	6.36E-22
UVM	CGC	RC3H1	KTN1	0.835068627	6.13E-22
UVM	CGC	RC3H1	ATRX	0.836408055	4.58E-22
UVM	CGC	RC3H1	GOPC	0.840156565	2.00E-22
UVM	CGC	RC3H1	FBXW7	0.842525724	1.17E-22
UVM	CGC	RC3H1	CUL3	0.843902373	8.56E-23
UVM	CGC	RC3H1	GOLGA5	0.844688615	7.14E-23
UVM	CGC	RC3H1	RGPD3	0.845012097	6.62E-23
UVM	CGC	RC3H1	AKAP9	0.847012986	4.15E-23
UVM	CGC	RC3H1	RANBP2	0.848508816	2.92E-23
UVM	CGC	RC3H1	PWWP2A	0.852794568	1.04E-23
UVM	CGC	RC3H1	USP8	0.854428946	6.93E-24
UVM	CGC	RC3H1	SMARCE1	0.855090216	5.88E-24
UVM	CGC	RC3H1	TET2	0.855257058	5.64E-24
UVM	CGC	RC3H1	DDX5	0.855808041	4.92E-24
UVM	CGC	RC3H1	KRAS	0.858465618	2.51E-24
UVM	CGC	RC3H1	BAZ1A	0.860335887	1.55E-24
UVM	CGC	RC3H1	SMAD4	0.860706236	1.41E-24
UVM	CGC	RC3H1	JAK2	0.862902009	7.91E-25
UVM	CGC	RC3H1	DICER1	0.863473855	6.80E-25
UVM	CGC	RC3H1	BMPR1A	0.86511974	4.38E-25
UVM	CGC	RC3H1	ATM	0.865508658	3.94E-25
UVM	CGC	RC3H1	KIF5B	0.865883929	3.56E-25
UVM	CGC	RC3H1	BCLAF1	0.866959124	2.66E-25
UVM	CGC	RC3H1	FBXO11	0.869309208	1.39E-25
UVM	CGC	RC3H1	ZMYM2	0.870146433	1.10E-25
UVM	CGC	RC3H1	MDM4	0.871538592	7.42E-26
UVM	CGC	RC3H1	XPO1	0.874512849	3.16E-26
UVM	CGC	RC3H1	SUZ12	0.875412887	2.43E-26
UVM	CGC	RC3H1	ARID2	0.877073241	1.49E-26
UVM	CGC	RC3H1	STAG2	0.881054322	4.45E-27
UVM	CGC	RC3H1	CREB1	0.88596479	9.46E-28
UVM	CGC	RC3H1	ETNK1	0.888946451	3.57E-28
UVM	CGC	RC3H1	SF3B1	0.892921035	9.31E-29
UVM	CGC	RC3H1	PMS1	0.921726975	8.01E-34
UVM	Epifactor	RC3H1	TADA1	0.801487567	4.28E-19
UVM	Epifactor	RC3H1	UCHL5	0.80381578	2.83E-19
UVM	Epifactor	RC3H1	MGA	0.806816382	1.65E-19
UVM	Epifactor	RC3H1	BRWD3	0.806821747	1.65E-19
UVM	Epifactor	RC3H1	LEO1	0.810155355	8.95E-20
UVM	Epifactor	RC3H1	RAD54B	0.812767616	5.50E-20
UVM	Epifactor	RC3H1	EID1	0.815070964	3.55E-20
UVM	Epifactor	RC3H1	TRIM24	0.815359587	3.36E-20
UVM	Epifactor	RC3H1	SS18L1	0.816024487	2.96E-20
UVM	Epifactor	RC3H1	PCGF3	0.816058495	2.94E-20
UVM	Epifactor	RC3H1	PSIP1	0.816859518	2.52E-20
UVM	Epifactor	RC3H1	PARG	0.818308513	1.91E-20
UVM	Epifactor	RC3H1	PHF14	0.82019327	1.32E-20
UVM	Epifactor	RC3H1	BRMS1L	0.820431455	1.26E-20
UVM	Epifactor	RC3H1	VRK1	0.820536783	1.23E-20
UVM	Epifactor	RC3H1	NFYB	0.821027693	1.12E-20
UVM	Epifactor	RC3H1	HAT1	0.822555232	8.26E-21
UVM	Epifactor	RC3H1	GATAD1	0.822978435	7.59E-21
UVM	Epifactor	RC3H1	CBX3	0.823364082	7.02E-21
UVM	Epifactor	RC3H1	MSL1	0.82428151	5.84E-21
UVM	Epifactor	RC3H1	ANP32E	0.825796538	4.30E-21
UVM	Epifactor	RC3H1	PCGF6	0.828057224	2.70E-21
UVM	Epifactor	RC3H1	TDG	0.833901985	7.89E-22
UVM	Epifactor	RC3H1	CDC73	0.83490203	6.36E-22
UVM	Epifactor	RC3H1	ATRX	0.836408055	4.58E-22
UVM	Epifactor	RC3H1	YEATS4	0.838009834	3.23E-22
UVM	Epifactor	RC3H1	ZMYND11	0.840007002	2.07E-22
UVM	Epifactor	RC3H1	ACTR6	0.840407513	1.89E-22
UVM	Epifactor	RC3H1	SIRT1	0.840654569	1.79E-22
UVM	Epifactor	RC3H1	SMARCA5	0.843532354	9.31E-23
UVM	Epifactor	RC3H1	CUL3	0.843902373	8.56E-23
UVM	Epifactor	RC3H1	SUDS3	0.845859424	5.44E-23
UVM	Epifactor	RC3H1	HCFC2	0.846377313	4.82E-23
UVM	Epifactor	RC3H1	CUL5	0.846829769	4.34E-23
UVM	Epifactor	RC3H1	BRCC3	0.849115314	2.52E-23
UVM	Epifactor	RC3H1	TLK1	0.849122089	2.52E-23
UVM	Epifactor	RC3H1	RMI1	0.849249195	2.45E-23
UVM	Epifactor	RC3H1	CDK17	0.849856938	2.11E-23
UVM	Epifactor	RC3H1	NSL1	0.850266866	1.92E-23
UVM	Epifactor	RC3H1	TLK2	0.850436008	1.84E-23
UVM	Epifactor	RC3H1	FAM175B	0.853427192	8.88E-24
UVM	Epifactor	RC3H1	SMARCE1	0.855090216	5.88E-24
UVM	Epifactor	RC3H1	TET2	0.855257058	5.64E-24
UVM	Epifactor	RC3H1	DNTTIP2	0.858896288	2.25E-24
UVM	Epifactor	RC3H1	UHRF2	0.859338012	2.01E-24
UVM	Epifactor	RC3H1	BAZ1A	0.860335887	1.55E-24
UVM	Epifactor	RC3H1	CHD1	0.862159136	9.63E-25
UVM	Epifactor	RC3H1	DNAJC2	0.862808111	8.11E-25
UVM	Epifactor	RC3H1	JAK2	0.862902009	7.91E-25
UVM	Epifactor	RC3H1	CTBP2	0.863592938	6.59E-25
UVM	Epifactor	RC3H1	USP15	0.865287819	4.18E-25
UVM	Epifactor	RC3H1	ATM	0.865508658	3.94E-25
UVM	Epifactor	RC3H1	TAF7	0.865537017	3.91E-25
UVM	Epifactor	RC3H1	RCOR3	0.868643979	1.67E-25
UVM	Epifactor	RC3H1	SMARCAD1	0.868843359	1.58E-25
UVM	Epifactor	RC3H1	OGT	0.868847362	1.58E-25
UVM	Epifactor	RC3H1	ZMYM2	0.870146433	1.10E-25
UVM	Epifactor	RC3H1	PRKAA1	0.872425473	5.76E-26
UVM	Epifactor	RC3H1	PHIP	0.87285675	5.09E-26
UVM	Epifactor	RC3H1	PHF20L1	0.874322371	3.34E-26
UVM	Epifactor	RC3H1	CHD9	0.874928697	2.80E-26
UVM	Epifactor	RC3H1	SUZ12	0.875412887	2.43E-26
UVM	Epifactor	RC3H1	EPC2	0.876628817	1.69E-26
UVM	Epifactor	RC3H1	HMGB1	0.876986326	1.52E-26
UVM	Epifactor	RC3H1	RLIM	0.877047497	1.50E-26
UVM	Epifactor	RC3H1	ARID2	0.877073241	1.49E-26
UVM	Epifactor	RC3H1	MBTD1	0.880094493	5.97E-27
UVM	Epifactor	RC3H1	SMEK2	0.880210818	5.76E-27
UVM	Epifactor	RC3H1	AEBP2	0.882902342	2.50E-27
UVM	Epifactor	RC3H1	ARID4B	0.884034373	1.75E-27
UVM	Epifactor	RC3H1	CIR1	0.888198391	4.57E-28
UVM	Epifactor	RC3H1	BAZ2B	0.888203002	4.56E-28
UVM	Epifactor	RC3H1	MASTL	0.888936115	3.58E-28
UVM	Epifactor	RC3H1	NIPBL	0.88944428	3.02E-28
UVM	Epifactor	RC3H1	CUL2	0.890379841	2.21E-28
UVM	Epifactor	RC3H1	SF3B1	0.892921035	9.31E-29
UVM	Epifactor	RC3H1	SMEK1	0.89420562	5.96E-29
UVM	Epifactor	RC3H1	BRWD1	0.898174834	1.45E-29
UVM	Epifactor	RC3H1	ATAD2B	0.900149386	7.02E-30
UVM	Epifactor	RC3H1	ARID4A	0.903922265	1.68E-30
UVM	Epifactor	RC3H1	JMJD1C	0.91321848	3.80E-32
UVM	Epifactor	RC3H1	INO80D	0.916251858	1.01E-32
UVM	IUPHAR	RC3H1	SLC39A10	0.801057682	4.61E-19
UVM	IUPHAR	RC3H1	PKN2	0.802378423	3.65E-19
UVM	IUPHAR	RC3H1	SLK	0.803846029	2.81E-19
UVM	IUPHAR	RC3H1	TAOK3	0.804111238	2.68E-19
UVM	IUPHAR	RC3H1	MAP3K2	0.804720228	2.41E-19
UVM	IUPHAR	RC3H1	NR3C1	0.804730374	2.40E-19
UVM	IUPHAR	RC3H1	ABCA10	0.805943137	1.93E-19
UVM	IUPHAR	RC3H1	STK38L	0.806570095	1.72E-19
UVM	IUPHAR	RC3H1	BRWD3	0.806821747	1.65E-19
UVM	IUPHAR	RC3H1	STK17A	0.807063658	1.58E-19
UVM	IUPHAR	RC3H1	ADAM17	0.807735741	1.40E-19
UVM	IUPHAR	RC3H1	PLK4	0.80882858	1.14E-19
UVM	IUPHAR	RC3H1	CYP2R1	0.809610933	9.89E-20
UVM	IUPHAR	RC3H1	HSP90AA1	0.810288169	8.73E-20
UVM	IUPHAR	RC3H1	PIKFYVE	0.813166831	5.10E-20
UVM	IUPHAR	RC3H1	ATP2B1	0.815130229	3.51E-20
UVM	IUPHAR	RC3H1	TAS2R14	0.815174872	3.48E-20
UVM	IUPHAR	RC3H1	TRIM24	0.815359587	3.36E-20
UVM	IUPHAR	RC3H1	PSMD14	0.816388814	2.76E-20
UVM	IUPHAR	RC3H1	IDI1	0.82042638	1.26E-20
UVM	IUPHAR	RC3H1	MALT1	0.820520849	1.24E-20
UVM	IUPHAR	RC3H1	VRK1	0.820536783	1.23E-20
UVM	IUPHAR	RC3H1	BIRC2	0.821024351	1.12E-20
UVM	IUPHAR	RC3H1	NEK7	0.821899361	9.41E-21
UVM	IUPHAR	RC3H1	HAT1	0.822555232	8.26E-21
UVM	IUPHAR	RC3H1	ACVR2A	0.823678714	6.59E-21
UVM	IUPHAR	RC3H1	NEK1	0.825682632	4.40E-21
UVM	IUPHAR	RC3H1	BMPR2	0.825974167	4.14E-21
UVM	IUPHAR	RC3H1	HMGCS1	0.826559404	3.68E-21
UVM	IUPHAR	RC3H1	USP14	0.826586067	3.66E-21
UVM	IUPHAR	RC3H1	RPS6KC1	0.826851476	3.46E-21
UVM	IUPHAR	RC3H1	CSNK1G3	0.827473073	3.05E-21
UVM	IUPHAR	RC3H1	SMG1	0.833710949	8.22E-22
UVM	IUPHAR	RC3H1	PRPF4B	0.839621735	2.26E-22
UVM	IUPHAR	RC3H1	ZMYND11	0.840007002	2.07E-22
UVM	IUPHAR	RC3H1	SIRT1	0.840654569	1.79E-22
UVM	IUPHAR	RC3H1	VRK2	0.843606194	9.16E-23
UVM	IUPHAR	RC3H1	ABCB10	0.843952183	8.46E-23
UVM	IUPHAR	RC3H1	CLK1	0.844296761	7.81E-23
UVM	IUPHAR	RC3H1	MAPK6	0.845732365	5.60E-23
UVM	IUPHAR	RC3H1	SENP6	0.84627652	4.94E-23
UVM	IUPHAR	RC3H1	IRAK4	0.846388321	4.81E-23
UVM	IUPHAR	RC3H1	TLK1	0.849122089	2.52E-23
UVM	IUPHAR	RC3H1	CDK17	0.849856938	2.11E-23
UVM	IUPHAR	RC3H1	TLK2	0.850436008	1.84E-23
UVM	IUPHAR	RC3H1	MTR	0.85261535	1.08E-23
UVM	IUPHAR	RC3H1	CLK4	0.857913585	2.89E-24
UVM	IUPHAR	RC3H1	KRAS	0.858465618	2.51E-24
UVM	IUPHAR	RC3H1	ATP6V0A2	0.858543084	2.46E-24
UVM	IUPHAR	RC3H1	BAZ1A	0.860335887	1.55E-24
UVM	IUPHAR	RC3H1	TBK1	0.861670926	1.09E-24
UVM	IUPHAR	RC3H1	JAK2	0.862902009	7.91E-25
UVM	IUPHAR	RC3H1	PLA2G12A	0.864091031	5.77E-25
UVM	IUPHAR	RC3H1	TNKS2	0.864611221	5.02E-25
UVM	IUPHAR	RC3H1	BMPR1A	0.86511974	4.38E-25
UVM	IUPHAR	RC3H1	MAP4K3	0.865402286	4.06E-25
UVM	IUPHAR	RC3H1	ATM	0.865508658	3.94E-25
UVM	IUPHAR	RC3H1	RIOK3	0.867019077	2.61E-25
UVM	IUPHAR	RC3H1	FBXO11	0.869309208	1.39E-25
UVM	IUPHAR	RC3H1	NR2C1	0.871354919	7.82E-26
UVM	IUPHAR	RC3H1	PRKAA1	0.872425473	5.76E-26
UVM	IUPHAR	RC3H1	PHIP	0.87285675	5.09E-26
UVM	IUPHAR	RC3H1	XPO1	0.874512849	3.16E-26
UVM	IUPHAR	RC3H1	TRPM7	0.87526757	2.53E-26
UVM	IUPHAR	RC3H1	MARK3	0.876545133	1.74E-26
UVM	IUPHAR	RC3H1	XIAP	0.877124106	1.46E-26
UVM	IUPHAR	RC3H1	BAZ2B	0.888203002	4.56E-28
UVM	IUPHAR	RC3H1	MASTL	0.888936115	3.58E-28
UVM	IUPHAR	RC3H1	BRWD1	0.898174834	1.45E-29
UVM	IUPHAR	RC3H1	ATAD2B	0.900149386	7.02E-30
UVM	IUPHAR	RC3H1	NAPEPLD	0.902262869	3.18E-30
UVM	IUPHAR	RC3H1	JMJD1C	0.91321848	3.80E-32
UVM	Kinase	RC3H1	PKN2	0.802378423	3.65E-19
UVM	Kinase	RC3H1	SLK	0.803846029	2.81E-19
UVM	Kinase	RC3H1	TAOK3	0.804111238	2.68E-19
UVM	Kinase	RC3H1	MAP3K2	0.804720228	2.41E-19
UVM	Kinase	RC3H1	STK38L	0.806570095	1.72E-19
UVM	Kinase	RC3H1	STK17A	0.807063658	1.58E-19
UVM	Kinase	RC3H1	PLK4	0.80882858	1.14E-19
UVM	Kinase	RC3H1	TRIM24	0.815359587	3.36E-20
UVM	Kinase	RC3H1	VRK1	0.820536783	1.23E-20
UVM	Kinase	RC3H1	NEK7	0.821899361	9.41E-21
UVM	Kinase	RC3H1	ACVR2A	0.823678714	6.59E-21
UVM	Kinase	RC3H1	NEK1	0.825682632	4.40E-21
UVM	Kinase	RC3H1	BMPR2	0.825974167	4.14E-21
UVM	Kinase	RC3H1	RPS6KC1	0.826851476	3.46E-21
UVM	Kinase	RC3H1	CSNK1G3	0.827473073	3.05E-21
UVM	Kinase	RC3H1	SMG1	0.833710949	8.22E-22
UVM	Kinase	RC3H1	PRPF4B	0.839621735	2.26E-22
UVM	Kinase	RC3H1	VRK2	0.843606194	9.16E-23
UVM	Kinase	RC3H1	CLK1	0.844296761	7.81E-23
UVM	Kinase	RC3H1	MAPK6	0.845732365	5.60E-23
UVM	Kinase	RC3H1	IRAK4	0.846388321	4.81E-23
UVM	Kinase	RC3H1	TLK1	0.849122089	2.52E-23
UVM	Kinase	RC3H1	CDK17	0.849856938	2.11E-23
UVM	Kinase	RC3H1	TLK2	0.850436008	1.84E-23
UVM	Kinase	RC3H1	CLK4	0.857913585	2.89E-24
UVM	Kinase	RC3H1	BAZ1A	0.860335887	1.55E-24
UVM	Kinase	RC3H1	TBK1	0.861670926	1.09E-24
UVM	Kinase	RC3H1	JAK2	0.862902009	7.91E-25
UVM	Kinase	RC3H1	BMPR1A	0.86511974	4.38E-25
UVM	Kinase	RC3H1	MAP4K3	0.865402286	4.06E-25
UVM	Kinase	RC3H1	ATM	0.865508658	3.94E-25
UVM	Kinase	RC3H1	PAN3	0.866045743	3.41E-25
UVM	Kinase	RC3H1	RIOK3	0.867019077	2.61E-25
UVM	Kinase	RC3H1	PRKAA1	0.872425473	5.76E-26
UVM	Kinase	RC3H1	TRPM7	0.87526757	2.53E-26
UVM	Kinase	RC3H1	MARK3	0.876545133	1.74E-26
UVM	Kinase	RC3H1	MASTL	0.888936115	3.58E-28
UVM	TF	RC3H1	RFX7	0.800290164	5.27E-19
UVM	TF	RC3H1	ZFX	0.800604803	4.99E-19
UVM	TF	RC3H1	ZNF286A	0.802817896	3.38E-19
UVM	TF	RC3H1	ZNF225	0.804076	2.70E-19
UVM	TF	RC3H1	ZNF443	0.804725465	2.41E-19
UVM	TF	RC3H1	NR3C1	0.804730374	2.40E-19
UVM	TF	RC3H1	ZNF223	0.804860857	2.35E-19
UVM	TF	RC3H1	HDX	0.805829943	1.97E-19
UVM	TF	RC3H1	ZNF440	0.806708594	1.68E-19
UVM	TF	RC3H1	MGA	0.806816382	1.65E-19
UVM	TF	RC3H1	ZNF148	0.808194614	1.28E-19
UVM	TF	RC3H1	ZNF674	0.808501243	1.21E-19
UVM	TF	RC3H1	ZNF189	0.808990756	1.11E-19
UVM	TF	RC3H1	ZNF529	0.809187978	1.07E-19
UVM	TF	RC3H1	ZSCAN29	0.809233239	1.06E-19
UVM	TF	RC3H1	BACH1	0.810041592	9.14E-20
UVM	TF	RC3H1	ZNF280C	0.810561948	8.30E-20
UVM	TF	RC3H1	SP4	0.810668662	8.13E-20
UVM	TF	RC3H1	TERF1	0.810751886	8.01E-20
UVM	TF	RC3H1	ZNF420	0.810812176	7.92E-20
UVM	TF	RC3H1	MYBL1	0.811533218	6.92E-20
UVM	TF	RC3H1	ELF1	0.811749962	6.65E-20
UVM	TF	RC3H1	ZNF461	0.812134613	6.19E-20
UVM	TF	RC3H1	MYNN	0.812590924	5.68E-20
UVM	TF	RC3H1	ZNF230	0.812735188	5.53E-20
UVM	TF	RC3H1	RLF	0.81295445	5.31E-20
UVM	TF	RC3H1	VEZF1	0.813568541	4.73E-20
UVM	TF	RC3H1	ZNF146	0.815003017	3.60E-20
UVM	TF	RC3H1	ZNF200	0.815280144	3.41E-20
UVM	TF	RC3H1	ZNF235	0.815560075	3.24E-20
UVM	TF	RC3H1	ZNF337	0.816030977	2.96E-20
UVM	TF	RC3H1	ZNF236	0.816461661	2.72E-20
UVM	TF	RC3H1	ZNF326	0.816515608	2.69E-20
UVM	TF	RC3H1	ZNF320	0.816632499	2.64E-20
UVM	TF	RC3H1	ZNF347	0.817537833	2.21E-20
UVM	TF	RC3H1	ZNF493	0.81803556	2.01E-20
UVM	TF	RC3H1	ZNF507	0.818087949	1.99E-20
UVM	TF	RC3H1	ZNF41	0.819214792	1.60E-20
UVM	TF	RC3H1	ZNF138	0.819336291	1.56E-20
UVM	TF	RC3H1	TMF1	0.819409168	1.54E-20
UVM	TF	RC3H1	ZNF564	0.819587277	1.48E-20
UVM	TF	RC3H1	NFYB	0.821027693	1.12E-20
UVM	TF	RC3H1	EEA1	0.821180585	1.08E-20
UVM	TF	RC3H1	ZNF131	0.821515824	1.02E-20
UVM	TF	RC3H1	ZFP14	0.821776691	9.64E-21
UVM	TF	RC3H1	NFAT5	0.82252603	8.30E-21
UVM	TF	RC3H1	ZNF611	0.823112786	7.39E-21
UVM	TF	RC3H1	SP3	0.824012497	6.16E-21
UVM	TF	RC3H1	NFXL1	0.824327902	5.78E-21
UVM	TF	RC3H1	ZNF799	0.82437836	5.73E-21
UVM	TF	RC3H1	JRKL	0.824510741	5.58E-21
UVM	TF	RC3H1	ZNF250	0.824820158	5.24E-21
UVM	TF	RC3H1	ZNF107	0.82547094	4.59E-21
UVM	TF	RC3H1	GABPA	0.826405165	3.79E-21
UVM	TF	RC3H1	ZNF557	0.82648683	3.73E-21
UVM	TF	RC3H1	PCGF6	0.828057224	2.70E-21
UVM	TF	RC3H1	ZNF254	0.829533835	1.99E-21
UVM	TF	RC3H1	ZNF845	0.83091998	1.49E-21
UVM	TF	RC3H1	ZNF585B	0.832880173	9.81E-22
UVM	TF	RC3H1	ZNF484	0.836231016	4.77E-22
UVM	TF	RC3H1	ZNF141	0.836611074	4.39E-22
UVM	TF	RC3H1	ZNF808	0.837457347	3.64E-22
UVM	TF	RC3H1	ZNF791	0.838106433	3.16E-22
UVM	TF	RC3H1	FOXN2	0.838653776	2.80E-22
UVM	TF	RC3H1	ZNF266	0.838679593	2.78E-22
UVM	TF	RC3H1	ZNF721	0.838760761	2.73E-22
UVM	TF	RC3H1	ZNF222	0.838928402	2.63E-22
UVM	TF	RC3H1	ZNF680	0.840718181	1.76E-22
UVM	TF	RC3H1	TTF1	0.841390766	1.52E-22
UVM	TF	RC3H1	ZNF354B	0.842597623	1.15E-22
UVM	TF	RC3H1	ZNF397	0.843150732	1.02E-22
UVM	TF	RC3H1	ZNF292	0.843645261	9.08E-23
UVM	TF	RC3H1	ZNF572	0.844113524	8.15E-23
UVM	TF	RC3H1	ZNF160	0.844508523	7.44E-23
UVM	TF	RC3H1	ZBED5	0.84470002	7.12E-23
UVM	TF	RC3H1	ZNF267	0.846062789	5.19E-23
UVM	TF	RC3H1	ZNF567	0.84674919	4.42E-23
UVM	TF	RC3H1	ZNF624	0.846837329	4.33E-23
UVM	TF	RC3H1	TOPORS	0.846876703	4.29E-23
UVM	TF	RC3H1	ZNF761	0.847222857	3.95E-23
UVM	TF	RC3H1	ZNF24	0.849134017	2.51E-23
UVM	TF	RC3H1	ZNF383	0.851084514	1.57E-23
UVM	TF	RC3H1	PRDM10	0.851671914	1.36E-23
UVM	TF	RC3H1	ZMAT1	0.851805257	1.32E-23
UVM	TF	RC3H1	THAP6	0.852623058	1.08E-23
UVM	TF	RC3H1	ZNF701	0.852933453	1.00E-23
UVM	TF	RC3H1	SMAD5	0.854156189	7.42E-24
UVM	TF	RC3H1	ZNF100	0.854213541	7.31E-24
UVM	TF	RC3H1	ZNF92	0.854522892	6.77E-24
UVM	TF	RC3H1	ZNF566	0.854982817	6.04E-24
UVM	TF	RC3H1	CEBPZ	0.854993879	6.03E-24
UVM	TF	RC3H1	TET2	0.855257058	5.64E-24
UVM	TF	RC3H1	ZNF12	0.855950184	4.74E-24
UVM	TF	RC3H1	ZNF268	0.856127507	4.54E-24
UVM	TF	RC3H1	ZNF430	0.856456976	4.18E-24
UVM	TF	RC3H1	ZNF23	0.856874524	3.76E-24
UVM	TF	RC3H1	ZNF83	0.857541307	3.18E-24
UVM	TF	RC3H1	ZBTB41	0.858100624	2.75E-24
UVM	TF	RC3H1	LIN54	0.858138559	2.73E-24
UVM	TF	RC3H1	MEF2A	0.858140095	2.73E-24
UVM	TF	RC3H1	ZNF37A	0.858777735	2.32E-24
UVM	TF	RC3H1	ZNF451	0.859188933	2.08E-24
UVM	TF	RC3H1	ZNF10	0.859919527	1.73E-24
UVM	TF	RC3H1	ZNF14	0.860465383	1.50E-24
UVM	TF	RC3H1	SMAD4	0.860706236	1.41E-24
UVM	TF	RC3H1	ZNF253	0.860896478	1.34E-24
UVM	TF	RC3H1	ZNF606	0.862387324	9.06E-25
UVM	TF	RC3H1	ZNF480	0.863605497	6.57E-25
UVM	TF	RC3H1	ZNF432	0.864655948	4.96E-25
UVM	TF	RC3H1	ZNF143	0.870231793	1.07E-25
UVM	TF	RC3H1	ZNF470	0.87057748	9.74E-26
UVM	TF	RC3H1	ZNF800	0.871129628	8.33E-26
UVM	TF	RC3H1	NR2C1	0.871354919	7.82E-26
UVM	TF	RC3H1	ZNF546	0.871914848	6.67E-26
UVM	TF	RC3H1	ZNF280D	0.872501793	5.64E-26
UVM	TF	RC3H1	ZNF780B	0.874478185	3.19E-26
UVM	TF	RC3H1	ELF2	0.875417855	2.42E-26
UVM	TF	RC3H1	THAP5	0.87659736	1.71E-26
UVM	TF	RC3H1	ARID2	0.877073241	1.49E-26
UVM	TF	RC3H1	ZNF44	0.877101775	1.47E-26
UVM	TF	RC3H1	ZNF28	0.877782575	1.20E-26
UVM	TF	RC3H1	ZNF449	0.878303662	1.03E-26
UVM	TF	RC3H1	ZNF260	0.878912631	8.55E-27
UVM	TF	RC3H1	ZNF527	0.88063772	5.06E-27
UVM	TF	RC3H1	ZNF708	0.882125817	3.19E-27
UVM	TF	RC3H1	AEBP2	0.882902342	2.50E-27
UVM	TF	RC3H1	ZNF780A	0.883088807	2.36E-27
UVM	TF	RC3H1	ZNF658	0.883862127	1.85E-27
UVM	TF	RC3H1	ZNF675	0.884606319	1.46E-27
UVM	TF	RC3H1	ZNF302	0.884854526	1.35E-27
UVM	TF	RC3H1	GPBP1	0.885712291	1.03E-27
UVM	TF	RC3H1	CREB1	0.88596479	9.46E-28
UVM	TF	RC3H1	RBAK	0.887182705	6.37E-28
UVM	TF	RC3H1	IKZF5	0.887336071	6.06E-28
UVM	TF	RC3H1	ZBTB6	0.887967435	4.93E-28
UVM	TF	RC3H1	BAZ2B	0.888203002	4.56E-28
UVM	TF	RC3H1	ZNF195	0.888243165	4.50E-28
UVM	TF	RC3H1	ZNF248	0.888318749	4.39E-28
UVM	TF	RC3H1	ZNF700	0.889007199	3.50E-28
UVM	TF	RC3H1	ZNF180	0.889592749	2.88E-28
UVM	TF	RC3H1	ZNF224	0.889638565	2.83E-28
UVM	TF	RC3H1	ZNF431	0.890774859	1.94E-28
UVM	TF	RC3H1	ZNF226	0.891125056	1.72E-28
UVM	TF	RC3H1	ZNF25	0.891539072	1.49E-28
UVM	TF	RC3H1	ZNF441	0.892055131	1.25E-28
UVM	TF	RC3H1	THAP9	0.89255177	1.06E-28
UVM	TF	RC3H1	ZNF234	0.899434063	9.15E-30
UVM	TF	RC3H1	ZNF75D	0.900174468	6.95E-30
UVM	TF	RC3H1	AHCTF1	0.901927004	3.61E-30
UVM	TF	RC3H1	ZNF182	0.902115543	3.36E-30
UVM	TF	RC3H1	ZNF136	0.903412649	2.05E-30
UVM	TF	RC3H1	ZNF181	0.904699054	1.24E-30
UVM	TF	RC3H1	ZNF510	0.905031696	1.09E-30
UVM	TF	RC3H1	ZNF43	0.906128809	7.09E-31
UVM	TF	RC3H1	ZNF518A	0.906315476	6.59E-31
UVM	TF	RC3H1	ZNF26	0.909575685	1.76E-31
UVM	TF	RC3H1	ZBTB1	0.913020726	4.14E-32
UVM	TF	RC3H1	ZNF84	0.91452787	2.16E-32
UVM	TF	RC3H1	CREBZF	0.91479509	1.92E-32
UVM	TF	RC3H1	ZNF33A	0.91659271	8.65E-33
UVM	TF	RC3H1	ZNF140	0.917277378	6.35E-33
UVM	TF	RC3H1	PURB	0.920695479	1.31E-33
UVM	TF	RC3H1	DMTF1	0.923881094	2.81E-34
UVM	TSG	RC3H1	PHF6	0.800540216	5.05E-19
UVM	TSG	RC3H1	PTPN2	0.804129356	2.68E-19
UVM	TSG	RC3H1	PNN	0.805429815	2.12E-19
UVM	TSG	RC3H1	PPP2R5C	0.808017747	1.33E-19
UVM	TSG	RC3H1	TRIM24	0.815359587	3.36E-20
UVM	TSG	RC3H1	CDKN1B	0.816334809	2.79E-20
UVM	TSG	RC3H1	PTPN12	0.817061276	2.43E-20
UVM	TSG	RC3H1	RBBP8	0.819137016	1.62E-20
UVM	TSG	RC3H1	APC	0.819779703	1.43E-20
UVM	TSG	RC3H1	NEDD4	0.823155628	7.32E-21
UVM	TSG	RC3H1	FAM188A	0.824185503	5.95E-21
UVM	TSG	RC3H1	BMPR2	0.825974167	4.14E-21
UVM	TSG	RC3H1	RB1CC1	0.833296763	8.98E-22
UVM	TSG	RC3H1	CDC73	0.83490203	6.36E-22
UVM	TSG	RC3H1	ZMYND11	0.840007002	2.07E-22
UVM	TSG	RC3H1	SIRT1	0.840654569	1.79E-22
UVM	TSG	RC3H1	TTF1	0.841390766	1.52E-22
UVM	TSG	RC3H1	FBXW7	0.842525724	1.17E-22
UVM	TSG	RC3H1	ZNF292	0.843645261	9.08E-23
UVM	TSG	RC3H1	CUL5	0.846829769	4.34E-23
UVM	TSG	RC3H1	TOPORS	0.846876703	4.29E-23
UVM	TSG	RC3H1	TANK	0.848215737	3.13E-23
UVM	TSG	RC3H1	PPM1A	0.849165312	2.49E-23
UVM	TSG	RC3H1	LIN9	0.853304038	9.15E-24
UVM	TSG	RC3H1	DCLRE1A	0.854303584	7.15E-24
UVM	TSG	RC3H1	INTS6	0.854776277	6.36E-24
UVM	TSG	RC3H1	TET2	0.855257058	5.64E-24
UVM	TSG	RC3H1	CCAR1	0.855480962	5.34E-24
UVM	TSG	RC3H1	UHRF2	0.859338012	2.01E-24
UVM	TSG	RC3H1	SMAD4	0.860706236	1.41E-24
UVM	TSG	RC3H1	CHD1	0.862159136	9.63E-25
UVM	TSG	RC3H1	DICER1	0.863473855	6.80E-25
UVM	TSG	RC3H1	IFT88	0.864652633	4.96E-25
UVM	TSG	RC3H1	BMPR1A	0.86511974	4.38E-25
UVM	TSG	RC3H1	ATM	0.865508658	3.94E-25
UVM	TSG	RC3H1	VEZT	0.871107493	8.38E-26
UVM	TSG	RC3H1	RINT1	0.871445711	7.62E-26
UVM	TSG	RC3H1	PRKAA1	0.872425473	5.76E-26
UVM	TSG	RC3H1	SMCHD1	0.872638926	5.42E-26
UVM	TSG	RC3H1	GGNBP2	0.873285506	4.50E-26
UVM	TSG	RC3H1	SUZ12	0.875412887	2.43E-26
UVM	TSG	RC3H1	PDS5B	0.876883453	1.57E-26
UVM	TSG	RC3H1	ARID2	0.877073241	1.49E-26
UVM	TSG	RC3H1	KRIT1	0.886215296	8.73E-28
UVM	TSG	RC3H1	CUL2	0.890379841	2.21E-28
UVM	TSG	RC3H1	GORAB	0.891968698	1.29E-28
UVM	TSG	RC3H1	APAF1	0.894315161	5.74E-29
UVM	TSG	RC3H1	NAPEPLD	0.902262869	3.18E-30
UVM	TSG	RC3H1	MLH3	0.902849626	2.54E-30
UVM	TSG	RC3H1	DMTF1	0.923881094	2.81E-34

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	RC3H1	UPF1	-1.33899089151335	0.000117696606626909
KIRC	RC3H1	RC3H2	-1.19348204164664	0.0001224322154943
COAD	RC3H1	NUFIP2	-2.74904714095693	0.0012979805469513
KIRP	RC3H1	CNOT2	-1.10448855710506	0.00222697434946895
LIHC	RC3H1	UPF1	-1.92491321082533	0.00427166918402987
HNSC	RC3H1	RQCD1	1.97297540658491	0.00585215220849023
THCA	RC3H1	NUFIP2	1.21346414930112	0.00745605759178186
KICH	RC3H1	CNOT3	-1.1461250404339	0.00882232189178467
BLCA	RC3H1	NUFIP2	-2.33563530587936	0.0108261108398438
LIHC	RC3H1	CNOT3	-1.23300348731276	3.17814170396599e-08
PRAD	RC3H1	UPF1	1.18312136515194	3.77428293642232e-05
BRCA	RC3H1	NUFIP2	1.59677387818332	4.86249064999326e-06
THCA	RC3H1	DDX6	-4.18593714762416	8.3083675979354e-06
BRCA	RC3H1	CNOT3	-2.12666858749727	9.14937084127887e-14

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RC3H1

CDA, DDX6, DDX1, ZC3H7B, WWOX, TNF, Hmgxb3, UBE2B, UBE2D2, UBE2G2, UBE2A, UBE2L3, UBE2F, UBE2G1, UBE2N, UBE2V1, UBE2V2, ACTG1, AKAP8L, ALB, ATP5A1, ATP5C1, C11orf84, CNOT11, CAD, CCDC124, CCT6A, CD2BP2, CIRBP, CKM, CLASP2, CMAS, CNOT1, CNOT10, CNOT2, CNOT3, CNOT6L, CNOT7, CNOT8, YBX3, DCD, DDX17, DDX46, E2F7, EDF1, EEF1D, EIF3I, EIF4B, EIF4G1, ERH, FARSA, FAU, FBL, FUS, GCN1L1, HIST1H1C, HNRNPA2B1, HNRNPK, HNRNPR, HNRNPU, HSPA5, HSPA6, HSPD1, IRS4, CAMSAP3, CCAR2, KIF11, KRT2, KRT5, KRT9, LARP1, LUC7L, LUC7L2, MAP7, MATR3, MCM7, MGA, MRPL14, MRPL24, NCAPH, NCL, NONO, NPM1, NUFIP2, OGT, OTUD4, PABPN1, PARP1, PEG10, PHGDH, PPIA, PPIB, PRDX4, PRPF31, PRPF6, PRSS3, PSMC3, PSMD11, PUM1, RAN, RAVER1, RBM3, RC3H2, RCC2, RIOK1, RNF219, RPL11, RPL12, RPL13, RPL18, RPL22, RPL23, RPL23A, RPL24, RPL27A, RPL28, RPL29, RPL30, RPL38, RPL4, RPL7, RPL8, RPL9, RPN1, RPS10, RPS11, RPS13, RPS14, RPS15A, RPS16, RPS17, RPS19, RPS2, RPS20, RPS24, RPS25, RPS3, RPS3A, RPS5, RPS6, RPS7, RPS8, RQCD1, SEC16A, SERBP1, SF3B2, SFPQ, SLC25A11, SLC25A3, SLC25A5, SMC2, SNRNP200, SNRPD2, SNRPD3, SRRM2, STAU1, STK38, STK38L, TNKS1BP1, TPM2, TRIM21, TRIM28, TYRP1, UBAP2L, VARS, VIM, WIZ, XRCC6, ZC3H4, ZBTB14, ZNF326, ZRANB2, TRIM25, ICOS, TNFRSF4, SRSF4, RCL1, CAPZB, PRKRA, EXOSC2, MRPL43, WDR36, YTHDC1, FXR2, RBM15, NCBP2, PDCD11, SRP72, NOC3L, PRPF4B, MARK2, U2SURP, DNAJC9, ATP5B, BAG4, EIF4A1, RPL13A, HNRNPD, SRSF7, ACTBL2, IGF2BP2, SF3B1, CORO1C, SF1, G3BP2, SPIN1, ZC3HAV1, PTBP1, DKC1, SRSF3, SRRM1, FAM120A, PWP1, RRP1B, EXOSC10, EIF6, PUF60, EWSR1, SLIRP, EFTUD2, TAB1, VCP, DHX15, MYCBP, BCLAF1, PLRG1, YBX1, ACTA1, CLNS1A, PRPF8, DDX3X, SART3, SNRPN, HNRNPAB, DHX30, LRPPRC, PCMT1, PRMT5, RPL17, HIST1H1E, PRPF19, RBM10, PABPC4, XRCC5, HIGD1A, DHX9, PABPC3, PRRC2A, USP9X, WDR77, SF3B3, IRAK1, PRDX1, HIST2H2AA4, SUN2, LYAR, SNRNP40, HIST1H2BB, HIST1H2BK, NAP1L1, C1QBP, KCTD5, SSBP1, HSPA9, HNRNPM, IGF2BP1, EEF1A1, TUBA1A, RPS27A, YWHAE, DNAJA3, HSPH1, DNAJA2, H1FX, MSI1, DNAJB6, ILF2, HAX1, EIF5B, DNAJA1, RBM39, YTHDF2, AIFM1, SRSF1, DDX52, DDX55, NUDT21, PES1, TRMT1L, PHF6, C1orf35, EIF3F, PAIP2, QPCTL, SRFBP1, TRA2B, LARP4B, FAM98A, PURA, SRSF9, NOP16, PABPC5, MRTO4, H2AFZ, SKIV2L2, THRAP3, SMARCC1, ZFR, GLYR1, KRI1, DDX50, MAZ, MRPL4, H1F0, LARP4, NOP2, MSI2, RBM28, BRIX1, CD3EAP, RRP12, BYSL, GNL3, LTV1, NOC4L, SPATA5L1, SLBP, ATXN2, RRP9, GPATCH4, AP2A2, POP1, MOV10, DHX57, ZCCHC3, AP2A1, ELAVL1, RSL1D1, CDK12, DDX21, SREK1, RBMS1, DHX37, RRS1, PLOD1, DDX56, POLRMT, RBM19, RFC5, MRPL52, PCBP1, U2AF2, NOP10, FUBP3, SRSF6, WIBG, SNRPA, PPAN-P2RY11, HNRNPDL, ASPH, BOP1, EPB41L5, NKRF, ANKHD1-EIF4EBP3, CCDC86, RBM14, FAM193A, RTCB, GRWD1, RBMX, YTHDC2, DDX28, NOP56, CAPRIN1, NOP58, RPL36A, POLR1B, HELZ, YWHAG, NKAP, REXO4, SNRNP70, SUGP2, C11orf98, PAN3, MTDH, RPF2, RBM34, SRSF2, LIN28B, ATXN2L, AP2B1, HADHA, RBBP7, ILF3, PRRC2C, EIF4ENIF1, MRPS27, HIST2H4B, HERC5, CPSF6, SRSF10, PATL1, NAF1, HIST2H2AB, UPF1, PCBP2, MYBBP1A, NIFK, DDX18, GNL2, RBM27, KPNA2, GNB2L1, IGF2BP3, ZCCHC9, C19orf53, C8orf33, NCBP1, NOP9, DHX36, SNRPA1, DDX54, UPF3B, GTPBP4, DDX24, GRSF1, USP10, TSR1, TBL3, ALYREF, YWHAB, FXR1, NHP2L1, SRBD1, PURB, RBM25, SRPK1, RNMTL1, YWHAQ, CHERP, CNP, SPNS1, RPS29, DIMT1, SNRPB2, HIST2H3D, HIST1H3D, KRR1, SKP1, ZCCHC24, H3F3B, CMSS1, ZNF512, LUC7L3, NAT10, TOP1, DDX41, RPF1, RBM42, PNO1, CELF1, DTWD2, FIP1L1, LARP1B, MELK, RFC1, SLC30A3, USP15, PIP5K1A, ZCCHC4, UTP18, EIF2A, ZNF668, SART1, GEMIN5, CKMT1A, TROVE2, CKAP2, MOGS, SDAD1, NOL6, MARK3, DDX47, SLC25A1, SRP68, MRPL39, ATP5J2-PTCD1, SRPK2, HSD17B10, SPATS2L, MORF4L2, NOA1, PTCD3, PHAX, XAB2, SPTY2D1, RFC3, RNF10, EIF2B2, TMA16, TDRD3, IMP4, MPHOSPH10, WDR55, MRPS10, MRPS16, MRPS17, MRPS18B, MRPS2, MRPS22, MRPS24, MRPS25, MRPS26, DAP3, MRPS31, MRPS34, MRPS35, MRPS5, MRPS6, MRPS9, MRPL1, MRPL11, MRPL12, MRPL15, MRPL20, MRPL22, MRPL23, MRPL27, MRPL3, MRPL41, MRPL46, MRPL50, MRPL53, MRPL54, RPS12, RPS15, RPS18, RPS21, RPS23, RPS27, RPS28, RPS4X, RPSA, RPLP0, RPLP1, RPLP2, RPL10, RPL10A, RPL14, RPL15, RPL18A, RPL19, RPL21, RPL22L1, RPL27, RPL3, RPL31, RPL32, RPL35, RPL36, RPL36AL, RPL37A, RPL5, RPL7A, NIP7, HSPA1A, HSPA4, HSPA4L, HSPA8, HSPB1, HSPA2, HNRNPA0, HNRNPA1, HNRNPF, HNRNPH1, HNRNPH2, HNRNPL, SYNCRIP, HNRNPUL1, HNRNPUL2, HNRNPC, TUBA1B, TUBA1C, TUBA4A, TUBA8, TUBB, SNRPE, SNRPG, SNRPD1, SPTBN1, KRT31, KRT10, KRT16, KRT85, KRT1, CDKN2A, ZC3H7A, WWP2, UCP3, N, AGO2, ALG13, ANKRD17, CEP85, CPEB4, DAZL, FAM120C, FMR1, G3BP1, LSM14A, MEX3B, MKRN2, PABPC1, PRRC2B, R3HDM2, RBM47, AGO1, AGO3, ARHGAP32, R3HDM1, RALY, SMG7, TNRC6B, TNRC6C, USP54, RNF214, SMAP2, TNRC6A, UNK, XRN1, YTHDF1, YTHDF3, ZFP36, CSDE1, ATAD3B, KIAA0355, HNRNPA3, IL6, CXCL2, DKK1, IRF2BPL, MMP2, RC3H1, IRF1, MEX3A, BAG2, PDCD6, DDX58, SQSTM1, SYNE3, EDC4, FAM168A, PHB2, STOML2, P4HB, PYCR2, GLA, CKB, PKM, AFG3L2, ALDH7A1, PDIA6, HSD17B4, SLC1A5, CPEB1,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RC3H1	chr1	173930919	C	T	single_nucleotide_variant	Uncertain_significance	See_cases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RC3H1	chr1	173930928	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RC3H1	chr1	173930949	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RC3H1	chr1	173931003	G	A	single_nucleotide_variant	Pathogenic	Hemophagocytic_lymphohistiocytosis,_familial,_6	SO:0001587\|nonsense	SO:0001587\|nonsense

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RC3H1	BLCA	chr1	173934254	173934254	G	A	Missense_Mutation	p.R447C	7
RC3H1	BRCA	chr1	173930909	173930909	T	C	Missense_Mutation	p.Y719C	4
RC3H1	UCS	chr1	173910505	173910505	G	T	Missense_Mutation	p.S1050Y	3
RC3H1	BRCA	chr1	173939653	173939653	C	T	Missense_Mutation	p.E442K	3
RC3H1	ESCA	chr1	173933252	173933252	C	G	Missense_Mutation	p.D564H	3
RC3H1	PRAD	chr1	173941766	173941767	-	TA	Splice_Site		3
RC3H1	SKCM	chr1	173915704	173915704	G	A	Silent	p.P957P	3
RC3H1	LIHC	chr1	173921238	173921238	T	-	Frame_Shift_Del	p.K803fs	3
RC3H1	HNSC	chr1	173952657	173952657	C	T	Missense_Mutation	p.R164Q	3
RC3H1	ACC	chr1	173947732	173947732	C	T	Silent	p.Q332Q	3
RC3H1	PAAD	chr1	173931058	173931058	G	A	Silent	p.H669H	3
RC3H1	UCEC	chr1	173916554	173916554	T	C	Missense_Mutation	p.Q897R	3
RC3H1	BRCA	chr1	173916616	173916616	C	G	Silent	p.V876	3
RC3H1	LIHC	chr1	173912722	173912722	T	C	Missense_Mutation		2
RC3H1	STAD	chr1	173953746	173953746	C	T	Silent	p.Q81Q	2
RC3H1	UCEC	chr1	173934205	173934205	A	C	Missense_Mutation	p.L463W	2
RC3H1	HNSC	chr1	173961928	173961928	C	A	Missense_Mutation	p.V66L	2
RC3H1	LUAD	chr1	173931109	173931109	G	A	Silent	p.N652N	2
RC3H1	PCPG	chr1	173950089	173950089	T	C	Missense_Mutation	p.Y276C	2
RC3H1	SKCM	chr1	173939703	173939703	C	T	Missense_Mutation	p.R425K	2
RC3H1	UCEC	chr1	173921239	173921239	T	C	Missense_Mutation	p.K803R	2
RC3H1	LIHC	chr1	173921269	173921269	T	A	Missense_Mutation		2
RC3H1	STAD	chr1	173912741	173912741	T	G	Silent	p.R992R	2
RC3H1	UCEC	chr1	173939754	173939754	G	T	Missense_Mutation	p.P408H	2
RC3H1	SKCM	chr1	173953695	173953695	T	G	Missense_Mutation	p.E98D	2
RC3H1	UCEC	chr1	173930222	173930222	G	A	Missense_Mutation	p.P788L	2
RC3H1	KIRC	chr1	173934019	173934019	A	G	Missense_Mutation	p.I525T	2
RC3H1	STAD	chr1	173915728	173915728	T	C	Silent	p.S949S	2
RC3H1	UCEC	chr1	173950064	173950064	G	A	Silent	p.D284	2
RC3H1	UCS	chr1	173907982	173907982	T	C	Silent	p.T1093T	2
RC3H1	CESC	chr1	173915654	173915654	T	A	Missense_Mutation		2
RC3H1	HNSC	chr1	173907909	173907909	C	A	Missense_Mutation	p.D1118Y	2
RC3H1	LUAD	chr1	173930982	173930982	C	T	Missense_Mutation	p.E695K	2
RC3H1	SKCM	chr1	173933267	173933267	G	A	Missense_Mutation	p.P559S	2
RC3H1	UCEC	chr1	173930270	173930270	G	A	Missense_Mutation	p.S772F	2
RC3H1	PAAD	chr1	173931058	173931058	G	A	Silent		2
RC3H1	UCEC	chr1	173951907	173951907	A	G	Silent	p.I242	2
RC3H1	UCS	chr1	173962048	173962048	G	A	Nonsense_Mutation	p.R26*	2
RC3H1	CESC	chr1	173933132	173933132	C	G	Missense_Mutation		2
RC3H1	ESCA	chr1	173931047	173931047	C	T	Missense_Mutation	p.R673H	2
RC3H1	HNSC	chr1	173951999	173951999	C	G	Missense_Mutation	p.E212Q	2
RC3H1	UCEC	chr1	173930297	173930297	G	A	Missense_Mutation	p.A763V	2
RC3H1	UCEC	chr1	173952678	173952678	G	A	Missense_Mutation	p.A157V	2
RC3H1	CESC	chr1	173961967	173961967	C	G	Missense_Mutation		2
RC3H1	SKCM	chr1	173949997	173949997	G	A	Missense_Mutation	p.L307F	2
RC3H1	UCEC	chr1	173930301	173930301	T	G	Missense_Mutation	p.M762L	2
RC3H1	BLCA	chr1	173916585	173916585	T	A	Nonsense_Mutation	p.K887*	2
RC3H1	LIHC	chr1	173947704	173947704	G	-	Frame_Shift_Del	p.Q342fs	2
RC3H1	UCEC	chr1	173952691	173952691	G	A	Missense_Mutation	p.R153C	2
RC3H1	SKCM	chr1	173962102	173962102	A	G	Missense_Mutation	p.W8R	2
RC3H1	STAD	chr1	173934070	173934070	A	G	Missense_Mutation	p.I508T	2
RC3H1	UCEC	chr1	173930366	173930366	C	T	Missense_Mutation	p.R740Q	2
RC3H1	BLCA	chr1	173930937	173930937	C	G	Missense_Mutation	p.E710Q	2
RC3H1	UCEC	chr1	173952773	173952773	A	T	Silent	p.T125	2
RC3H1	HNSC	chr1	173915954	173915954	G	A	Missense_Mutation	p.H920Y	2
RC3H1	SKCM	chr1	173952757	173952757	G	C	Missense_Mutation	p.R131G	2
RC3H1	STAD	chr1	173950010	173950010	C	T	Silent	p.Q302Q	2
RC3H1	UCEC	chr1	173930905	173930905	T	C	Silent	p.P720	2
RC3H1	BLCA	chr1	173953689	173953689	C	T	Silent	p.K100K	2
RC3H1	KIRP	chr1	173916659	173916660	GT	-	Frame_Shift_Del	p.862_862del	2
RC3H1	UCEC	chr1	173953661	173953661	A	C	Missense_Mutation	p.L110V	2
RC3H1	ESCA	chr1	173933252	173933252	C	G	Missense_Mutation		2
RC3H1	LUAD	chr1	173949963	173949963	T	A	Missense_Mutation	p.Q318L	2
RC3H1	KIRP	chr1	173916659	173916660	GT	-	Frame_Shift_Del	p.T862fs	2
RC3H1	SKCM	chr1	173930261	173930261	G	A	Missense_Mutation	p.P775L	2
RC3H1	STAD	chr1	173931083	173931083	T	C	Missense_Mutation	p.Q661R	2
RC3H1	UCEC	chr1	173931091	173931091	C	A	Missense_Mutation	p.Q658H	2
RC3H1	BLCA	chr1	173952637	173952637	G	C	Missense_Mutation	p.L171V	2
RC3H1	COAD	chr1	173962058	173962058	G	A	Silent	p.D22D	2
RC3H1	HNSC	chr1	173952661	173952661	C	A	Nonsense_Mutation	p.E163*	2
RC3H1	UCEC	chr1	173961984	173961984	C	T	Missense_Mutation	p.R47H	2
RC3H1	SKCM	chr1	173933295	173933295	G	C	Silent	p.A549A	2
RC3H1	STAD	chr1	173951935	173951935	C	T	Missense_Mutation	p.R233Q	2
RC3H1	UCEC	chr1	173933139	173933139	C	T	Silent	p.P601	2
RC3H1	HNSC	chr1	173934113	173934113	G	C	Missense_Mutation	p.P494A	2
RC3H1	UCEC	chr1	173907927	173907927	C	T	Missense_Mutation	p.D1112N	2
RC3H1	STAD	chr1	173952672	173952672	C	T	Missense_Mutation	p.R159Q	2
RC3H1	UCEC	chr1	173934064	173934064	C	T	Missense_Mutation	p.R510Q	2
RC3H1	BLCA	chr1	173907942	173907942	G	C	Missense_Mutation	p.L1107V	2
RC3H1	HNSC	chr1	173934116	173934116	G	T	Missense_Mutation	p.L493M	2
RC3H1	LUAD	chr1	173947753	173947753	C	A	Missense_Mutation	p.Q325H	2
RC3H1	UCEC	chr1	173907947	173907947	C	A	Missense_Mutation	p.S1105I	2
RC3H1	BLCA	chr1	173916678	173916678	G	A	Nonsense_Mutation	p.Q856*	2
RC3H1	HNSC	chr1	173961928	173961928	C	A	Missense_Mutation		1
RC3H1	OV	chr1	172208270	172208270	C	T	Silent	p.Q407	1
RC3H1	BLCA	chr1	173951947	173951947	C	A	Missense_Mutation		1
RC3H1	BLCA	chr1	173921267	173921267	C	T	Missense_Mutation	p.E794K	1
RC3H1	THYM	chr1	173962060	173962060	C	T	Missense_Mutation	p.D22N	1
RC3H1	UCS	chr1	173962048	173962048	G	A	Nonsense_Mutation	p.R26X	1
RC3H1	BLCA	chr1	173939705	173939705	C	G	Missense_Mutation		1
RC3H1	DLBC	chr1	173916598	173916598	G	A	Silent	p.I882I	1
RC3H1	LUAD	chr1	173941763	173941763	C	A	Missense_Mutation	p.A369S	1
RC3H1	SKCM	chr1	173951933	173951933	A	G	Missense_Mutation	p.F234L	1
RC3H1	BLCA	chr1	173951947	173951947	C	A	Missense_Mutation	p.R229I	1
RC3H1	COAD	chr1	173950102	173950102	C	A	Nonsense_Mutation	p.E272X	1
RC3H1	ESCA	chr1	173933139	173933139	C	T	Silent	p.P601P	1
RC3H1	KIRC	chr1	173921186	173921186	A	G	Missense_Mutation	p.Y821H	1
RC3H1	HNSC	chr1	173934113	173934113	G	C	Missense_Mutation		1
RC3H1	OV	chr1	172228624	172228624	G	C	Missense_Mutation	p.C41W	1
RC3H1	BLCA	chr1	173953648	173953648	C	T	Missense_Mutation		1
RC3H1	BLCA	chr1	173930270	173930270	G	C	Missense_Mutation	p.S772C	1
RC3H1	THYM	chr1	173947725	173947725	G	T	Missense_Mutation	p.Q335K	1
RC3H1	BLCA	chr1	173915656	173915656	C	T	Silent		1
RC3H1	HNSC	chr1	173952772	173952772	G	C	Missense_Mutation	p.Q126E	1
RC3H1	LUAD	chr1	173915621	173915621	C	T	Missense_Mutation	p.G985E	1
RC3H1	PRAD	chr1	173910517	173910517	T	C	Splice_Site	p.E1046_splice	1
RC3H1	LUAD	chr1	173952657	173952657	C	A	Missense_Mutation	p.R164L	1
RC3H1	SKCM	chr1	173921254	173921254	A	G	Missense_Mutation	p.V798A	1
RC3H1	BLCA	chr1	173934023	173934023	T	G	Missense_Mutation	p.K524Q	1
RC3H1	COAD	chr1	173952711	173952711	A	G	Missense_Mutation	p.V146A	1
RC3H1	ESCA	chr1	173933996	173933996	G	A	Missense_Mutation	p.P533S	1
RC3H1	HNSC	chr1	173912683	173912683	G	T	Missense_Mutation		1
RC3H1	LIHC	chr1	173934198	173934198	T	A	Missense_Mutation	p.Q465H	1
RC3H1	LIHC	chr1	173916638	173916638	G	-	Frame_Shift_Del	p.P869fs	1
RC3H1	OV	chr1	173953671	173953671	T	C	Silent	p.L106	1
RC3H1	BLCA	chr1	173934216	173934216	C	G	Missense_Mutation		1
RC3H1	BLCA	chr1	173939705	173939705	C	G	Missense_Mutation	p.Q424H	1
RC3H1	THYM	chr1	173947636	173947636	G	T	Missense_Mutation	p.D364E	1
RC3H1	BLCA	chr1	173921231	173921231	C	T	Missense_Mutation		1
RC3H1	ESCA	chr1	173933253	173933253	T	A	Silent	p.A563	1
RC3H1	LUSC	chr1	173930262	173930262	G	A	Missense_Mutation	p.P775S	1
RC3H1	SKCM	chr1	173952775	173952775	T	G	Missense_Mutation	p.T125P	1
RC3H1	BLCA	chr1	173934216	173934216	C	G	Missense_Mutation	p.L459F	1
RC3H1	ESCA	chr1	173933996	173933996	G	A	Missense_Mutation		1
RC3H1	KIRC	chr1	173950062	173950074	GAGTCATGTTCTC	-	Frame_Shift_Del	p.281_285del	1
RC3H1	HNSC	chr1	173912614	173912614	C	A	Missense_Mutation		1
RC3H1	LIHC	chr1	173912722	173912722	T	C	Missense_Mutation	p.E998G	1
RC3H1	LIHC	chr1	173934020	173934020	T	-	Frame_Shift_Del	p.I525fs	1
RC3H1	STAD	chr1	173930312	173930312	C	T	Missense_Mutation	p.R758Q	1
RC3H1	BLCA	chr1	173931017	173931017	C	T	Missense_Mutation		1
RC3H1	BLCA	chr1	173910450	173910450	T	C	Silent	p.P1068P	1
RC3H1	UCEC	chr1	173907927	173907927	C	T	Missense_Mutation	p.D1113N	1
RC3H1	BLCA	chr1	173947732	173947732	C	G	Missense_Mutation		1
RC3H1	LUAD	chr1	173912666	173912666	G	A	Missense_Mutation	p.P1017S	1
RC3H1	READ	chr1	173947709	173947709	G	A	Missense_Mutation	p.A340V	1
RC3H1	LUSC	chr1	173907969	173907969	T	A	Missense_Mutation	p.S1099C	1
RC3H1	SKCM	chr1	173952619	173952619	G	C	Missense_Mutation	p.Q177E	1
RC3H1	BLCA	chr1	173931017	173931017	C	T	Missense_Mutation	p.R683K	1
RC3H1	HNSC	chr1	173934116	173934116	G	T	Missense_Mutation		1
RC3H1	KIRC	chr1	173930378	173930378	G	A	Missense_Mutation	p.P736L	1
RC3H1	HNSC	chr1	173931010	173931010	C	G	Missense_Mutation		1
RC3H1	LIHC	chr1	173952029	173952029	C	-	Frame_Shift_Del	p.E202fs	1
RC3H1	PAAD	chr1	173947683	173947683	T	G	Missense_Mutation		1
RC3H1	STAD	chr1	173962014	173962014	A	G	Missense_Mutation	p.V37A	1
RC3H1	BLCA	chr1	173930937	173930937	C	G	Missense_Mutation		1
RC3H1	BLCA	chr1	173921231	173921231	C	T	Missense_Mutation	p.D806N	1
RC3H1	UCEC	chr1	173933237	173933237	G	T	Missense_Mutation	p.P569T	1
RC3H1	BLCA	chr1	173915918	173915918	G	C	Missense_Mutation		1
RC3H1	ESCA	chr1	173934234	173934234	C	A	Silent	p.L453	1
RC3H1	LUAD	chr1	173931080	173931080	T	A	Missense_Mutation	p.Y662F	1
RC3H1	SARC	chr1	173950028	173950028	T	A	Missense_Mutation		1
RC3H1	LUSC	chr1	173916691	173916691	C	A	Missense_Mutation	p.Q851H	1
RC3H1	SKCM	chr1	173907985	173907985	C	G	Missense_Mutation	p.L1092F	1
RC3H1	HNSC	chr1	173931002	173931002	C	A	Missense_Mutation		1
RC3H1	KIRC	chr1	173950062	173950074	GAGTCATGTTCTC	-	Frame_Shift_Del	p.REHDS281fs	1
RC3H1	BLCA	chr1	173953689	173953689	C	T	Silent		1
RC3H1	BLCA	chr1	173947732	173947732	C	G	Missense_Mutation	p.Q332H	1
RC3H1	HNSC	chr1	173961953	173961953	G	T	Silent		1
RC3H1	LIHC	chr1	173951968	173951968	A	-	Frame_Shift_Del	p.L222fs	1
RC3H1	PAAD	chr1	173939719	173939719	G	T	Silent		1
RC3H1	STAD	chr1	173934066	173934066	C	T	Silent	p.P509P	1
RC3H1	UCEC	chr1	173952773	173952773	A	T	Silent	p.T125T	1
RC3H1	BLCA	chr1	173939703	173939703	C	G	Missense_Mutation		1
RC3H1	CESC	chr1	173915654	173915654	T	A	Missense_Mutation	p.N974I	1
RC3H1	ESCA	chr1	173933253	173933253	T	A	Silent		1
RC3H1	HNSC	chr1	173931010	173931010	C	G	Missense_Mutation	p.E685D	1
RC3H1	LUAD	chr1	173930920	173930920	G	A	Silent	p.I715I	1
RC3H1	SARC	chr1	173934179	173934179	G	T	Missense_Mutation		1
RC3H1	LUSC	chr1	173931198	173931198	G	A	Missense_Mutation	p.R623C	1
RC3H1	ACC	chr1	173912683	173912683	G	A	Missense_Mutation	p.P1011L	1
RC3H1	HNSC	chr1	173907909	173907909	C	A	Missense_Mutation		1
RC3H1	KIRP	chr1	173921219	173921219	A	G	Missense_Mutation	p.Y810H	1
RC3H1	BLCA	chr1	173952637	173952637	G	C	Missense_Mutation		1
RC3H1	BLCA	chr1	173915918	173915918	G	C	Missense_Mutation	p.Q932E	1
RC3H1	HNSC	chr1	173952700	173952702	CTT	-	In_Frame_Del		1
RC3H1	LIHC	chr1	173921233	173921233	T	-	Frame_Shift_Del	p.N805fs	1
RC3H1	STAD	chr1	173939714	173939714	A	G	Silent	p.D421D	1
RC3H1	BLCA	chr1	173934024	173934024	T	C	Silent		1
RC3H1	CESC	chr1	173961967	173961967	C	G	Missense_Mutation	p.D53H	1
RC3H1	ESCA	chr1	173934234	173934234	C	A	Silent		1
RC3H1	LUAD	chr1	173907935	173907935	A	G	Missense_Mutation	p.L1109P	1
RC3H1	SARC	chr1	173962042	173962042	G	T	Missense_Mutation		1
RC3H1	LUSC	chr1	173931144	173931144	G	A	Missense_Mutation	p.H641Y	1
RC3H1	BLCA	chr1	173947722	173947722	C	T	Missense_Mutation		1
RC3H1	HNSC	chr1	173952657	173952657	C	T	Missense_Mutation		1
RC3H1	BLCA	chr1	173916674	173916674	C	G	Missense_Mutation		1
RC3H1	BLCA	chr1	173952641	173952641	G	A	Silent	p.L169L	1
RC3H1	HNSC	chr1	173951938	173951938	G	A	Missense_Mutation		1
RC3H1	LUAD	chr1	173939679	173939679	C	T	Missense_Mutation	p.S433N	1
RC3H1	PAAD	chr1	173951980	173951980	G	T	Nonsense_Mutation	p.S218X	1
RC3H1	THCA	chr1	173916627	173916627	G	T	Silent		1
RC3H1	UCEC	chr1	173962024	173962024	C	A	Missense_Mutation	p.G34C	1
RC3H1	BLCA	chr1	173947722	173947722	C	T	Missense_Mutation	p.E336K	1
RC3H1	COAD	chr1	173915731	173915731	C	T	Missense_Mutation	p.M948I	1
RC3H1	HNSC	chr1	173951938	173951938	G	A	Missense_Mutation	p.P232L	1
RC3H1	SARC	chr1	173915679	173915679	G	T	Missense_Mutation		1
RC3H1	LUSC	chr1	173933297	173933297	C	A	Missense_Mutation	p.A549S	1
RC3H1	BLCA	chr1	173934254	173934254	G	A	Missense_Mutation		1
RC3H1	HNSC	chr1	173915954	173915954	G	A	Missense_Mutation		1
RC3H1	BLCA	chr1	173907942	173907942	G	C	Missense_Mutation		1
RC3H1	BLCA	chr1	173939703	173939703	C	G	Missense_Mutation	p.R425T	1
RC3H1	LUAD	chr1	173933262	173933262	C	A	Missense_Mutation	p.R560S	1
RC3H1	PAAD	chr1	173910415	173910415	G	A	Missense_Mutation	p.T1080I	1
RC3H1	THCA	chr1	173934007	173934007	C	T	Missense_Mutation	p.S529N	1
RC3H1	UCEC	chr1	173947627	173947628	-	G	Frame_Shift_Ins	p.D368_splice	1
RC3H1	COAD	chr1	173916541	173916541	A	G	Silent	p.P901P	1
RC3H1	ESCA	chr1	173934234	173934234	C	A	Silent	p.L453L	1
RC3H1	HNSC	chr1	173952700	173952702	CTT	-	In_Frame_Del	p.EG149del	1
RC3H1	LUAD	chr1	173953758	173953758	C	A	Splice_Site		1
RC3H1	SARC	chr1	173939678	173939678	G	T	Missense_Mutation		1
RC3H1	HNSC	chr1	173952772	173952772	G	C	Missense_Mutation		1
RC3H1	KIRP	chr1	173933112	173933112	C	A	Missense_Mutation		1
RC3H1	LUSC	chr1	173930278	173930278	C	A	Missense_Mutation	p.K769N	1
RC3H1	BLCA	chr1	173941653	173941653	C	A	Missense_Mutation		1
RC3H1	BLCA	chr1	173916674	173916674	C	G	Missense_Mutation	p.R857T	1
RC3H1	BLCA	chr1	173921267	173921267	C	T	Missense_Mutation		1
RC3H1	BLCA	chr1	173934024	173934024	T	C	Silent	p.G523G	1
RC3H1	COAD	chr1	173941727	173941727	G	T	Missense_Mutation	p.L381M	1
RC3H1	LUAD	chr1	173930234	173930234	G	A	Missense_Mutation	p.P784L	1
RC3H1	PAAD	chr1	173947683	173947683	T	G	Missense_Mutation	p.N349H	1
RC3H1	THYM	chr1	173953655	173953655	G	T	Missense_Mutation		1
RC3H1	UCS	chr1	173907982	173907982	T	C	Silent		1
RC3H1	BLCA	chr1	173941653	173941653	C	A	Missense_Mutation	p.Q405H	1
RC3H1	COAD	chr1	173930350	173930350	G	A	Silent	p.P745P	1
RC3H1	ESCA	chr1	173933253	173933253	T	A	Silent	p.A563A	1
RC3H1	KICH	chr1	173921192	173921192	C	A	Missense_Mutation		1
RC3H1	LUAD	chr1	173951987	173951987	C	T	Missense_Mutation	p.A216T	1
RC3H1	SARC	chr1	173950028	173950028	T	A	Missense_Mutation	p.L296F	1
RC3H1	HNSC	chr1	173951999	173951999	C	G	Missense_Mutation		1
RC3H1	LGG	chr1	173930321	173930321	T	A	Missense_Mutation	p.H755L	1
RC3H1	OV	chr1	173962095	173962095	T	A	Missense_Mutation	p.D10V	1
RC3H1	SKCM	chr1	173912702	173912702	G	A	Nonsense_Mutation	p.Q1005*	1
RC3H1	BLCA	chr1	173934023	173934023	T	G	Missense_Mutation		1
RC3H1	BLCA	chr1	173930270	173930270	G	C	Missense_Mutation		1
RC3H1	DLBC	chr1	173951933	173951933	A	T	Missense_Mutation	p.F234I	1
RC3H1	PCPG	chr1	173950089	173950089	T	C	Missense_Mutation		1
RC3H1	THYM	chr1	173950044	173950044	G	A	Missense_Mutation	p.A291V	1
RC3H1	UCS	chr1	173910505	173910505	G	T	Missense_Mutation		1
RC3H1	COAD	chr1	173950025	173950025	T	G	Silent	p.R297R	1
RC3H1	ESCA	chr1	173941652	173941652	G	A	Nonsense_Mutation	p.Q406X	1
RC3H1	KICH	chr1	173912597	173912597	T	C	Missense_Mutation	p.T1040A	1
RC3H1	LUAD	chr1	173910431	173910431	G	A	Missense_Mutation	p.P1075S	1
RC3H1	SARC	chr1	173910489	173910489	G	T	Missense_Mutation	p.S1055R	1

Copy number variation (CNV) of RC3H1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RC3H1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
80778	SARC	TCGA-DX-AB2S-01A	ASH1L	chr1	155531944	-	RC3H1	chr1	173962273	-
73113	STAD	TCGA-RD-A8MV-01A	RC3H1	chr1	173941647	-	CENPL	chr1	173780444	-
73113	STAD	TCGA-RD-A8MV-01A	RC3H1	chr1	173941647	-	CENPL	chr1	173793157	-
101214	N/A	BI493738	RC3H1	chr1	173921278	-	HSP90AA1	chr14	102547387	+
101348	N/A	BE147849	RC3H1	chr1	173914078	+	MTMR6	chr13	25852367	+
80778	N/A	DW438066	RC3H1	chr1	173907485	-	RC3H1	chr1	173907775	-
101541	N/A	AI991787	RC3H1	chr1	173962233	+	SATB1	chr3	18390226	+
98605	COAD	TCGA-A6-2676-01A	RC3H1	chr1	173991234	-	SERPINC1	chr1	173876652	-
80780	LIHC	TCGA-ZS-A9CF-02A	SERPINC1	chr1	173878525	-	RC3H1	chr1	173900621	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RC3H1	0.00047936896016492	0.013
ACC	RC3H1	0.0291376395291083	0.79
THYM	RC3H1	0.0322337425344377	0.84
SARC	RC3H1	0.0433860185342496	1
LIHC	RC3H1	0.0444095009272052	1

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	RC3H1	0.0187542958588505	0.6
LGG	RC3H1	0.0389137953004408	1
BRCA	RC3H1	0.0400834814352765	1
SARC	RC3H1	0.000340489738646451	0.011

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0024291	Lymphohistiocytosis, Hemophagocytic	1	GENOMICS_ENGLAND