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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: LSM14B (NCBI Gene ID:149986)

Gene Summary

Gene Summary

Gene Information	Gene Name: LSM14B
	Gene ID: 149986
	Gene Symbol	LSM14B
	Gene ID	149986
	Gene Name	LSM family member 14B
	Synonyms	C20orf40\|FAM61B\|FT005\|LSM13\|RAP55B\|bA11M20.3
	Cytomap	20q13.33
	Type of Gene	protein-coding
	Description	protein LSM14 homolog BLSM14 homolog BLSM14B, SCD6 homolog BRNA-associated protein 55Bfamily with sequence similarity 61, member BhRAP55B
	Modification date	20200327
	UniProtAcc	Q9BX40

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
LSM14B	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'LSM14B[title] AND translation [title] AND human.'

Gene	Title	PMID
LSM14B	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000279068	60701359	60701495	Frame-shift
ENST00000279068	60704840	60705008	In-frame
ENST00000279068	60705274	60705352	In-frame
ENST00000279068	60708345	60708531	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000279068	60704840	60705008	2565	588	755	385	142	198
ENST00000279068	60705274	60705352	2565	756	833	385	198	224

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9BX40	142	198	2	385	Chain	ID=PRO_0000187093;Note=Protein LSM14 homolog B
Q9BX40	198	224	2	385	Chain	ID=PRO_0000187093;Note=Protein LSM14 homolog B
Q9BX40	142	198	154	154	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
Q9BX40	142	198	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9BX40	142	198	45	142	Alternative sequence	ID=VSP_014659;Note=In isoform 3. SFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAASSLLSQQYAASLGL->MAPYGPLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGCLFCFRSLFTYTQSHIVLFRVPTGPGTLEREEMER;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9BX40	142	198	143	220	Alternative sequence	ID=VSP_014660;Note=In isoform 2. GAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQ->EKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSPCS;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9BX40	198	224	143	220	Alternative sequence	ID=VSP_014660;Note=In isoform 2. GAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQ->EKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSPCS;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	LSM14B	-2.25703219479764	0.00390625
STAD	LSM14B	-1.04497961394163	0.0139979305677116
KICH	LSM14B	-1.99774835906046	1.50799751281738e-05
PRAD	LSM14B	-3.81113021286116	1.68487044723013e-05
LUAD	LSM14B	-1.99667623004912	1.92117385607053e-06
KIRP	LSM14B	-1.03944906543717	8.74791294336319e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
READ	LSM14B	-0.089335527	0.004724402
LGG	LSM14B	0.136648511	0.019291856

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with LSM14B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Epifactor	LSM14B	TAF4	0.889706914	2.20E-113
DLBC	Epifactor	LSM14B	TAF4	0.873835035	5.23E-16
GBM	TF	LSM14B	ZNF512B	0.844072222	7.05E-48
LUAD	Epifactor	LSM14B	TAF4	0.802478469	7.83E-131
LUSC	Epifactor	LSM14B	TAF4	0.800934255	7.77E-125
READ	CGC	LSM14B	SS18L1	0.810810891	1.06E-25
READ	Epifactor	LSM14B	SS18L1	0.810810891	1.06E-25
READ	Epifactor	LSM14B	TAF4	0.911290078	1.75E-41
READ	TSG	LSM14B	DIDO1	0.806928811	2.71E-25
THYM	CGC	LSM14B	TOP1	0.812100638	7.52E-30
THYM	Epifactor	LSM14B	YY1	0.813751268	4.67E-30
THYM	Epifactor	LSM14B	TADA1	0.815147731	3.11E-30
THYM	IUPHAR	LSM14B	TOP1	0.812100638	7.52E-30
THYM	TF	LSM14B	TOPORS	0.803931598	7.45E-29
THYM	TF	LSM14B	ZNF567	0.807637013	2.67E-29
THYM	TF	LSM14B	YY1	0.813751268	4.67E-30
THYM	TSG	LSM14B	TOPORS	0.803931598	7.45E-29
UCS	CGC	LSM14B	TOP1	0.812100638	7.52E-30
UCS	Epifactor	LSM14B	YY1	0.813751268	4.67E-30
UCS	Epifactor	LSM14B	TADA1	0.815147731	3.11E-30
UCS	IUPHAR	LSM14B	TOP1	0.812100638	7.52E-30
UCS	TF	LSM14B	TOPORS	0.803931598	7.45E-29
UCS	TF	LSM14B	ZNF567	0.807637013	2.67E-29
UCS	TF	LSM14B	YY1	0.813751268	4.67E-30
UCS	TSG	LSM14B	TOPORS	0.803931598	7.45E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
HNSC	LSM14B	DCP1B	1.14521055486121	0.000653586169164556
COAD	LSM14B	DCP1A	1.37134624374913	0.00241076946258545
BLCA	LSM14B	DCP1A	-4.97262066067438	0.0033416748046875
THCA	LSM14B	EDC3	-1.60072094283068	0.00403018908583426
STAD	LSM14B	DCP1B	-1.13498768546097	0.00828406633809209
KIRC	LSM14B	DCP2	1.26475649682567	0.0124189994647713
CHOL	LSM14B	PABPC1L	2.78331172494241	0.01953125
CHOL	LSM14B	BICC1	2.98219972165231	0.02734375
PRAD	LSM14B	BICC1	1.12504584917467	0.0350092650357157
STAD	LSM14B	PATL1	1.64176209311139	1.11940316855908e-05
LUAD	LSM14B	PABPC1L	-2.51583026501524	1.30692790027182e-05
PRAD	LSM14B	EDC3	1.41585676363778	1.51985731338595e-07
LUAD	LSM14B	DCP1A	-1.72675426206094	1.6717782354243e-05
BRCA	LSM14B	DCP1A	-1.83830661187261	1.93681541154994e-23
LUSC	LSM14B	PABPC1L	-2.50538171229714	3.79466966402315e-05
STAD	LSM14B	PABPC1L	-2.43245436541992	4.02145087718964e-06
LIHC	LSM14B	PABPC1L	-2.77562492714404	6.17267413816717e-05
LUAD	LSM14B	EDC3	-1.96767005947362	6.36796101058976e-06
BRCA	LSM14B	EIF4ENIF1	-1.8000022968001	7.32601452453987e-06
KICH	LSM14B	PABPC1L	2.22531868187715	7.49826431274414e-05
THCA	LSM14B	DDX6	-4.18593714762416	8.3083675979354e-06
LIHC	LSM14B	EDC3	-1.35008737111713	9.26293949573469e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with LSM14B

HECW2, LGR4, DDX6, SEMG2, SEMG1, SIRT3, ICK, LUC7L, NTRK1, DCTN1, XPO1, SMC1A, HUWE1, PHF8, C1qbp, Iffo1, POU5F1, CLEC3A, BHLHA15, GTF3C2, CHCHD10, CASP3, G3BP1, PTCH1, ESR2, HEXIM1, MEPCE, EZH2, RECQL4, SNRNP70, ITFG1, WWP2, HOMER3, WDYHV1, TCEANC, ZC3H18, N, nsp9, ESR1, DAZL, DCP1A, EIF4ENIF1, LSM14A, MEX3B, MOV10, UBAP2L, YTHDF2, YTHDF3, ZC3HAV1, AGO2, CAPRIN1, DDX3X, FAM120C, FXR2, TDRD3, ZFP36, FUBP3, IGF2BP1, IGF2BP2, KIAA0430, HNRNPH1, ZMYND11, OGT, FBL, RPS20, FZR1, PRM2, CHCHD2, PSMD9, RPL37, DDX54, C17orf85, SEPT9, FBXW7, TOP3B, CPEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
LSM14B	KIRP	chr20	60705292	60705292	G	A	Missense_Mutation	p.A205T	5
LSM14B	BLCA	chr20	60697842	60697842	C	A	Silent		5
LSM14B	UCEC	chr20	60705677	60705677	C	T	Silent	p.F255	4
LSM14B	ESCA	chr20	60701373	60701373	C	T	Missense_Mutation		4
LSM14B	ESCA	chr20	60701373	60701373	C	T	Missense_Mutation	p.S102F	3
LSM14B	BRCA	chr20	60705737	60705737	G	T	Silent	p.L275	3
LSM14B	ESCA	chr20	60708434	60708434	C	T	Missense_Mutation	p.R359W	3
LSM14B	BRCA	chr20	60708435	60708435	G	C	Missense_Mutation	p.R359P	3
LSM14B	UCEC	chr20	60705594	60705594	C	T	Nonsense_Mutation	p.R228*	3
LSM14B	HNSC	chr20	60706468	60706468	G	A	Missense_Mutation	p.E298K	3
LSM14B	UCEC	chr20	60705329	60705329	G	A	Missense_Mutation	p.R217K	3
LSM14B	ESCA	chr20	60705584	60705584	A	G	Splice_Site		3
LSM14B	PAAD	chr20	60701454	60701454	G	A	Missense_Mutation	p.S129N	3
LSM14B	SKCM	chr20	60701385	60701385	C	T	Missense_Mutation	p.S106L	3
LSM14B	UCEC	chr20	60701479	60701479	C	T	Silent	p.A137	2
LSM14B	BRCA	chr20	60701300	60701300	G	A	Missense_Mutation	p.E104K	2
LSM14B	KIRC	chr20	60701436	60701436	A	G	Missense_Mutation	p.Y123C	2
LSM14B	PRAD	chr20	60708507	60708507	G	T	Missense_Mutation	p.G383V	2
LSM14B	STAD	chr20	60704997	60704997	A	G	Missense_Mutation	p.K195R	2
LSM14B	UCEC	chr20	60704910	60704910	C	A	Missense_Mutation	p.A166D	2
LSM14B	BRCA	chr20	60706418	60706418	A	T	Missense_Mutation	p.K281M	2
LSM14B	STAD	chr20	60706523	60706523	A	C	Missense_Mutation	p.K316T	2
LSM14B	UCEC	chr20	60705000	60705000	C	T	Missense_Mutation	p.T196M	2
LSM14B	BLCA	chr20	60704841	60704841	G	A	Splice_Site	p.G143E	2
LSM14B	STAD	chr20	60704949	60704949	G	A	Missense_Mutation	p.G179D	2
LSM14B	UCEC	chr20	60705625	60705625	G	A	Missense_Mutation	p.R238H	2
LSM14B	BLCA	chr20	60697745	60697745	C	T	Missense_Mutation	p.P8L	2
LSM14B	STAD	chr20	60704864	60704864	G	A	Missense_Mutation	p.V151I	2
LSM14B	BLCA	chr20	60708371	60708371	G	C	Missense_Mutation	p.E338Q	2
LSM14B	CESC	chr20	60708354	60708354	G	A	Missense_Mutation		2
LSM14B	SKCM	chr20	60701392	60701392	C	T	Silent	p.F108F	2
LSM14B	UCEC	chr20	60706415	60706415	A	G	Missense_Mutation	p.D280G	2
LSM14B	BLCA	chr20	60706476	60706476	C	T	Silent	p.P300P	2
LSM14B	CESC	chr20	60702804	60702804	G	C	Silent		2
LSM14B	LGG	chr20	60701373	60701373	C	G	Missense_Mutation	p.S102C	2
LSM14B	SKCM	chr20	60705335	60705335	C	T	Missense_Mutation	p.P219L	2
LSM14B	PAAD	chr20	60701454	60701454	G	A	Missense_Mutation		2
LSM14B	PAAD	chr20	60701305	60701305	C	T	Silent		2
LSM14B	UCEC	chr20	60706442	60706442	A	G	Missense_Mutation	p.D289G	2
LSM14B	ESCA	chr20	60708434	60708434	C	T	Missense_Mutation		2
LSM14B	BLCA	chr20	60706547	60706547	C	T	Missense_Mutation	p.S324F	2
LSM14B	UCEC	chr20	60708446	60708446	C	T	Nonsense_Mutation	p.R363*	2
LSM14B	SKCM	chr20	60701364	60701364	C	T	Missense_Mutation	p.S99F	2
LSM14B	UCEC	chr20	60701310	60701310	G	A	Missense_Mutation	p.R107Q	2
LSM14B	PCPG	chr20	60701439	60701439	G	T	Missense_Mutation		2
LSM14B	UCEC	chr20	60701386	60701386	G	A	Silent	p.S106	2
LSM14B	BRCA	chr20	60699699	60699699	C	T	Missense_Mutation	p.P52S	2
LSM14B	PCPG	chr20	60701439	60701439	G	T	Missense_Mutation	p.G124V	2
LSM14B	STAD	chr20	60699742	60699742	A	G	Missense_Mutation	p.Y66C	2
LSM14B	LIHC	chr20	60699717	60699717	C	-	Frame_Shift_Del	p.P59fs	2
LSM14B	BLCA	chr20	60706476	60706476	C	T	Silent		1
LSM14B	GBM	chr20	60697790	60697790	G	A	Missense_Mutation	p.R23H	1
LSM14B	COAD	chr20	60701443	60701443	G	A	Silent	p.P125P	1
LSM14B	LIHC	chr20	60706428	60706428	G	-	Frame_Shift_Del	p.K284fs	1
LSM14B	BLCA	chr20	60704907	60704907	C	T	Missense_Mutation		1
LSM14B	GBM	chr20	60701495	60701495	G	T	Nonsense_Mutation		1
LSM14B	KIRP	chr20	60705652	60705652	T	C	Missense_Mutation	p.I247T	1
LSM14B	PRAD	chr20	60701437	60701437	C	T	Silent	p.Y123Y	1
LSM14B	LIHC	chr20	60708481	60708481	C	-	Frame_Shift_Del	p.N374fs	1
LSM14B	GBM	chr20	60704961	60704961	C	T	Missense_Mutation		1
LSM14B	KIRP	chr20	60704972	60704972	G	C	Missense_Mutation	p.G187R	1
LSM14B	SARC	chr20	60701309	60701309	C	T	Missense_Mutation		1
LSM14B	LUAD	chr20	60706504	60706504	T	A	Missense_Mutation	p.C310S	1
LSM14B	HNSC	chr20	60706468	60706468	G	A	Missense_Mutation		1
LSM14B	SARC	chr20	60704083	60704083	A	G	Missense_Mutation		1
LSM14B	ESCA	chr20	60704986	60704986	G	A	Silent	p.Q191	1
LSM14B	LUSC	chr20	60701381	60701381	G	T	Missense_Mutation	p.A105S	1
LSM14B	HNSC	chr20	60705703	60705703	G	A	Missense_Mutation		1
LSM14B	KIRP	chr20	60697753	60697753	G	C	Missense_Mutation	p.G11R	1
LSM14B	THYM	chr20	60708385	60708385	C	A	Missense_Mutation	p.N342K	1
LSM14B	ESCA	chr20	60705584	60705584	A	G	Splice_Site	e6-2	1
LSM14B	LUSC	chr20	60699680	60699680	C	T	Silent	p.S45S	1
LSM14B	HNSC	chr20	60705703	60705703	G	A	Missense_Mutation	p.R264Q	1
LSM14B	BLCA	chr20	60704907	60704907	C	T	Missense_Mutation	p.S165F	1
LSM14B	CESC	chr20	60704872	60704872	G	A	Silent	p.K153K	1
LSM14B	LGG	chr20	60701380	60701380	C	A	Silent		1
LSM14B	SKCM	chr20	60705702	60705702	C	T	Nonsense_Mutation	p.R264X	1
LSM14B	UCEC	chr20	60701479	60701479	C	T	Silent	p.A137A	1
LSM14B	HNSC	chr20	60697741	60697742	-	C	Frame_Shift_Ins	p.P7fs	1
LSM14B	PAAD	chr20	60705702	60705702	C	A	Silent		1
LSM14B	CESC	chr20	60697842	60697842	C	T	Silent	p.L40	1
LSM14B	LIHC	chr20	60705603	60705603	A	G	Missense_Mutation		1
LSM14B	BLCA	chr20	60705660	60705660	G	C	Missense_Mutation	p.E250Q	1
LSM14B	KIRC	chr20	60708449	60708449	G	A	Missense_Mutation	p.G364R	1
LSM14B	UCS	chr20	60701448	60701448	C	T	Missense_Mutation	p.A127V	1
LSM14B	CESC	chr20	60702804	60702804	G	C	Silent	p.L197	1
LSM14B	LIHC	chr20	60706512	60706512	T	C	Silent		1
LSM14B	SKCM	chr20	60705702	60705702	C	T	Nonsense_Mutation	p.R264*	1
LSM14B	ESCA	chr20	60705584	60705584	A	G	Splice_Site	.	1
LSM14B	BLCA	chr20	60697761	60697761	G	C	Missense_Mutation	p.K13N	1
LSM14B	KIRC	chr20	60708460	60708460	C	A	Silent	p.G367G	1
LSM14B	COAD	chr20	60699716	60699716	G	A	Silent	p.A57A	1
LSM14B	LIHC	chr20	60706422	60706422	T	C	Silent	p.A282A	1
LSM14B	BLCA	chr20	60708371	60708371	G	C	Missense_Mutation		1
LSM14B	ESCA	chr20	60704986	60704986	G	A	Silent	p.Q191Q	1
LSM14B	KIRC	chr20	60705692	60705692	C	G	Silent	p.A260A	1
LSM14B	COAD	chr20	60701401	60701401	C	T	Silent	p.H111H	1

Copy number variation (CNV) of LSM14B
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Fusion gene breakpoints (product of the structural variants (SVs)) across LSM14B
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
26954	N/A	BF919146	BTNL9	chr5	180469231	+	LSM14B	chr20	60709217	+
26954	N/A	AW847911	CKB	chr14	103988480	+	LSM14B	chr20	60701377	+
26956	UCS	TCGA-N9-A4PZ	EPHA2	chr1	16474872	-	LSM14B	chr20	60699672	+
26956	UCS	TCGA-N9-A4PZ-01A	EPHA2	chr1	16474873	-	LSM14B	chr20	60699673	+
96696	N/A	AA886089	LSM14B	chr20	60710430	+	AGAP1	chr2	236782167	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	LSM14B	0.000562077820168222	0.016
ESCA	LSM14B	0.0160076093696215	0.43
ACC	LSM14B	0.0229504681554702	0.6

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	LSM14B	0.0134210180939307	0.38
THCA	LSM14B	0.0273328418956131	0.74
SKCM	LSM14B	0.000893200069847471	0.029
OV	LSM14B	0.000774046610665992	0.026
CESC	LSM14B	0.00100809679206964	0.031
ESCA	LSM14B	0.0127292364945664	0.37
MESO	LSM14B	0.035899251564287	0.93
HNSC	LSM14B	0.00309992528351534	0.093

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source