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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DAPK3 (NCBI Gene ID:1613)

Gene Summary

Gene Summary

Gene Information	Gene Name: DAPK3
	Gene ID: 1613
	Gene Symbol	DAPK3
	Gene ID	1613
	Gene Name	death associated protein kinase 3
	Synonyms	DLK\|ZIP\|ZIPK
	Cytomap	19p13.3
	Type of Gene	protein-coding
	Description	death-associated protein kinase 3DAP kinase 3DAP-like kinaseMYPT1 kinaseZIP-kinasezipper-interacting protein kinase
	Modification date	20200329
	UniProtAcc	O43293

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DAPK3	GO:0006468	protein phosphorylation	10356987
Hgene	DAPK3	GO:0006915	apoptotic process	10580117
Hgene	DAPK3	GO:0017148	negative regulation of translation	18995835
Hgene	DAPK3	GO:0035556	intracellular signal transduction	10356987
Hgene	DAPK3	GO:0043065	positive regulation of apoptotic process	21487036
Hgene	DAPK3	GO:0046777	protein autophosphorylation	18239682
Hgene	DAPK3	GO:0051893	regulation of focal adhesion assembly	23454120
Hgene	DAPK3	GO:0071346	cellular response to interferon-gamma	18995835
Hgene	DAPK3	GO:2000249	regulation of actin cytoskeleton reorganization	23454120

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DAPK3	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'DAPK3[title] AND translation [title] AND human.'

Gene	Title	PMID
DAPK3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000301264	3960056	3960102	Frame-shift
ENST00000545797	3960056	3960102	Frame-shift
ENST00000301264	3963640	3963667	In-frame
ENST00000545797	3963640	3963667	In-frame

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	DAPK3	-2.45923064978283	0.000429689884185791
BLCA	DAPK3	-4.45304308049294	0.000965118408203125
LIHC	DAPK3	-2.50328895901681	0.0021424331410393
KIRP	DAPK3	-1.12189290917215	0.00879816571250558
BRCA	DAPK3	-1.06864719608467	3.44197818935778e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
PRAD	DAPK3	3	2	0.000304172938416755	0.63997197080292	0.478905804878049	0.0129014736384431	0.149487409191295

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	DAPK3	0.034980347	0.028155853
LUSC	DAPK3	-0.077810267	0.049672185

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DAPK3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	Cell metabolism gene	DAPK3	DOHH	0.825691612	1.29E-304
CHOL	Epifactor	DAPK3	SIRT6	0.864061417	2.11E-14
CHOL	IUPHAR	DAPK3	SIRT6	0.864061417	2.11E-14
CHOL	TSG	DAPK3	SIRT6	0.864061417	2.11E-14
DLBC	Cell metabolism gene	DAPK3	PSMD4	0.837679977	1.14E-13
DLBC	Cell metabolism gene	DAPK3	MED16	0.849918511	2.16E-14
DLBC	CGC	DAPK3	TFPT	0.841372674	7.02E-14
DLBC	Epifactor	DAPK3	MBD3	0.82260758	7.42E-13
DLBC	Epifactor	DAPK3	ZGPAT	0.83646818	1.34E-13
DLBC	Epifactor	DAPK3	TFPT	0.841372674	7.02E-14
DLBC	IUPHAR	DAPK3	SLC39A3	0.817132311	1.40E-12
DLBC	TF	DAPK3	PIN1	0.809707884	3.21E-12
DLBC	TF	DAPK3	MBD3	0.82260758	7.42E-13
DLBC	TF	DAPK3	ZGPAT	0.83646818	1.34E-13
DLBC	TSG	DAPK3	MAD1L1	0.802596483	6.88E-12
DLBC	TSG	DAPK3	PIN1	0.809707884	3.21E-12
DLBC	TSG	DAPK3	TSSC4	0.836700575	1.30E-13
THCA	Cell metabolism gene	DAPK3	DOHH	0.806452442	3.52E-132
THYM	Cell metabolism gene	DAPK3	MTX1	0.802207607	1.19E-28
THYM	Cell metabolism gene	DAPK3	TXNRD2	0.803399122	8.61E-29
THYM	Cell metabolism gene	DAPK3	PGLS	0.80398954	7.33E-29
THYM	Cell metabolism gene	DAPK3	NME2	0.806030477	4.18E-29
THYM	Cell metabolism gene	DAPK3	PYCRL	0.806896566	3.28E-29
THYM	Cell metabolism gene	DAPK3	MED16	0.809489243	1.58E-29
THYM	Cell metabolism gene	DAPK3	TIMM50	0.813781116	4.63E-30
THYM	Cell metabolism gene	DAPK3	TIMM13	0.815221131	3.04E-30
THYM	Cell metabolism gene	DAPK3	GEMIN7	0.816551741	2.06E-30
THYM	Cell metabolism gene	DAPK3	NANS	0.817843002	1.40E-30
THYM	Cell metabolism gene	DAPK3	ALG3	0.830467196	2.81E-32
THYM	Cell metabolism gene	DAPK3	PTGES2	0.842310639	5.30E-34
THYM	Cell metabolism gene	DAPK3	HMOX2	0.844592318	2.38E-34
THYM	Cell metabolism gene	DAPK3	PMPCA	0.858467718	1.34E-36
THYM	Cell metabolism gene	DAPK3	EXOSC4	0.871100544	7.26E-39
THYM	Cell metabolism gene	DAPK3	DOHH	0.873507978	2.52E-39
THYM	Cell metabolism gene	DAPK3	GMPPA	0.875275774	1.15E-39
THYM	CGC	DAPK3	ASPSCR1	0.83460488	7.28E-33
THYM	Epifactor	DAPK3	PRMT1	0.800929569	1.68E-28
THYM	Epifactor	DAPK3	BRMS1	0.805341336	5.05E-29
THYM	Epifactor	DAPK3	SIRT6	0.813239265	5.42E-30
THYM	Epifactor	DAPK3	EXOSC4	0.871100544	7.26E-39
THYM	IUPHAR	DAPK3	PRMT1	0.800929569	1.68E-28
THYM	IUPHAR	DAPK3	SLC39A3	0.801462248	1.46E-28
THYM	IUPHAR	DAPK3	EGLN2	0.809657259	1.51E-29
THYM	IUPHAR	DAPK3	SIRT6	0.813239265	5.42E-30
THYM	IUPHAR	DAPK3	ATP6V0B	0.819866427	7.66E-31
THYM	IUPHAR	DAPK3	PTGES2	0.842310639	5.30E-34
THYM	IUPHAR	DAPK3	HMOX2	0.844592318	2.38E-34
THYM	TF	DAPK3	ZNF688	0.803929337	7.45E-29
THYM	TF	DAPK3	NME2	0.806030477	4.18E-29
THYM	TF	DAPK3	KLF16	0.812117162	7.49E-30
THYM	TF	DAPK3	ZNF787	0.816627611	2.01E-30
THYM	TF	DAPK3	ZNF581	0.834110762	8.58E-33
THYM	TSG	DAPK3	GADD45GIP1	0.802394304	1.13E-28
THYM	TSG	DAPK3	BRMS1	0.805341336	5.05E-29
THYM	TSG	DAPK3	PYCARD	0.807694492	2.63E-29
THYM	TSG	DAPK3	SIRT6	0.813239265	5.42E-30
THYM	TSG	DAPK3	TSSC4	0.835935717	4.68E-33
THYM	TSG	DAPK3	STUB1	0.879793675	1.44E-40
UCS	Cell metabolism gene	DAPK3	MTX1	0.802207607	1.19E-28
UCS	Cell metabolism gene	DAPK3	TXNRD2	0.803399122	8.61E-29
UCS	Cell metabolism gene	DAPK3	PGLS	0.80398954	7.33E-29
UCS	Cell metabolism gene	DAPK3	NME2	0.806030477	4.18E-29
UCS	Cell metabolism gene	DAPK3	PYCRL	0.806896566	3.28E-29
UCS	Cell metabolism gene	DAPK3	MED16	0.809489243	1.58E-29
UCS	Cell metabolism gene	DAPK3	TIMM50	0.813781116	4.63E-30
UCS	Cell metabolism gene	DAPK3	TIMM13	0.815221131	3.04E-30
UCS	Cell metabolism gene	DAPK3	GEMIN7	0.816551741	2.06E-30
UCS	Cell metabolism gene	DAPK3	NANS	0.817843002	1.40E-30
UCS	Cell metabolism gene	DAPK3	ALG3	0.830467196	2.81E-32
UCS	Cell metabolism gene	DAPK3	PTGES2	0.842310639	5.30E-34
UCS	Cell metabolism gene	DAPK3	HMOX2	0.844592318	2.38E-34
UCS	Cell metabolism gene	DAPK3	PMPCA	0.858467718	1.34E-36
UCS	Cell metabolism gene	DAPK3	EXOSC4	0.871100544	7.26E-39
UCS	Cell metabolism gene	DAPK3	DOHH	0.873507978	2.52E-39
UCS	Cell metabolism gene	DAPK3	GMPPA	0.875275774	1.15E-39
UCS	CGC	DAPK3	ASPSCR1	0.83460488	7.28E-33
UCS	Epifactor	DAPK3	PRMT1	0.800929569	1.68E-28
UCS	Epifactor	DAPK3	BRMS1	0.805341336	5.05E-29
UCS	Epifactor	DAPK3	SIRT6	0.813239265	5.42E-30
UCS	Epifactor	DAPK3	EXOSC4	0.871100544	7.26E-39
UCS	IUPHAR	DAPK3	PRMT1	0.800929569	1.68E-28
UCS	IUPHAR	DAPK3	SLC39A3	0.801462248	1.46E-28
UCS	IUPHAR	DAPK3	EGLN2	0.809657259	1.51E-29
UCS	IUPHAR	DAPK3	SIRT6	0.813239265	5.42E-30
UCS	IUPHAR	DAPK3	ATP6V0B	0.819866427	7.66E-31
UCS	IUPHAR	DAPK3	PTGES2	0.842310639	5.30E-34
UCS	IUPHAR	DAPK3	HMOX2	0.844592318	2.38E-34
UCS	TF	DAPK3	ZNF688	0.803929337	7.45E-29
UCS	TF	DAPK3	NME2	0.806030477	4.18E-29
UCS	TF	DAPK3	KLF16	0.812117162	7.49E-30
UCS	TF	DAPK3	ZNF787	0.816627611	2.01E-30
UCS	TF	DAPK3	ZNF581	0.834110762	8.58E-33
UCS	TSG	DAPK3	GADD45GIP1	0.802394304	1.13E-28
UCS	TSG	DAPK3	BRMS1	0.805341336	5.05E-29
UCS	TSG	DAPK3	PYCARD	0.807694492	2.63E-29
UCS	TSG	DAPK3	SIRT6	0.813239265	5.42E-30
UCS	TSG	DAPK3	TSSC4	0.835935717	4.68E-33
UCS	TSG	DAPK3	STUB1	0.879793675	1.44E-40
UVM	IUPHAR	DAPK3	GSK3A	0.82048413	1.24E-20
UVM	IUPHAR	DAPK3	PRKD2	0.822153636	8.94E-21
UVM	Kinase	DAPK3	GSK3A	0.82048413	1.24E-20
UVM	Kinase	DAPK3	PRKD2	0.822153636	8.94E-21
UVM	TF	DAPK3	ZBTB45	0.813951727	4.40E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	DAPK3	MAPK1	1.27319002595358	0.000911891460418701
LUAD	DAPK3	PAWR	2.12177813415454	0.00100010249745768
BRCA	DAPK3	MAPK3	-1.61909976139263	0.00193136402459222
CHOL	DAPK3	MAPK3	-1.54068193424676	0.00390625
CHOL	DAPK3	PPP1R12A	-3.96213486529692	0.00390625
STAD	DAPK3	PPP1R12A	-1.97938788154196	0.0044123362749815
COAD	DAPK3	DAPK1	2.68646464485495	0.00613072514533998
CHOL	DAPK3	RAB28	-1.99010241537231	0.0078125
BLCA	DAPK3	PPP1R12A	-2.78876802599308	0.0108261108398438
ESCA	DAPK3	MAPK1	-1.17755474324053	0.0185546875
HNSC	DAPK3	BECN1	-2.30930109461252	0.0224968952327345
UCEC	DAPK3	RAB28	-3.84992231507818	0.03125
CHOL	DAPK3	DAPK2	-1.74955728080755	0.0390625
BRCA	DAPK3	MAPK1	-1.67954875219151	0.0427276834041307
LUSC	DAPK3	PAWR	3.19248868526954	1.36166975509391e-09
BRCA	DAPK3	DAPK2	-2.50345596778055	1.77848292217128e-22
BRCA	DAPK3	PPP1R12A	-1.60156833405818	1.79190012161022e-11
LIHC	DAPK3	DAPK1	-1.54053752323258	1.9834194260622e-05
LUAD	DAPK3	DAPK1	-1.41443013929251	2.06541148982154e-09
PRAD	DAPK3	PPP1R12A	-1.3153988861503	2.48181746506057e-07
THCA	DAPK3	DAPK1	2.39123267848336	3.38795198769543e-06
LUAD	DAPK3	DAPK2	-2.91995076881182	3.79251210274868e-11
COAD	DAPK3	MAPK3	-1.17173283146352	5.66244125366212e-07
HNSC	DAPK3	PAWR	1.09718825091027	6.99092674949499e-06
PRAD	DAPK3	RAB28	1.21544661412272	7.43626332249267e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DAPK3

DAXX, PAWR, Atf4, GRB14, PRKCZ, UBE2D3, NEDD4L, RAD21, CDKN1A, MDM2, DAPK3, TP53, CHEK2, HSP90AA1, AK3, TCP10L, RPL34, AR, AATF, TSG101, ULK1, CEP170, GPS2, PCM1, CEP104, CEP128, CNTRL, NINL, CAPZA2, CDK2, FLNA, MYH9, PPP1CB, IQGAP1, SYNPO, LIMA1, MYO5C, MYO19, MYO18A, Actb, Cd2ap, Flot2, Itga5, Myh9, Myo1c, Tpm1, Coro1c, Dctn3, Mad2l1, Myh10, Flnb, CDC14A, KIF2B, MEAF6, TNFRSF8, KLHDC3, ESR2, NT5M, ACTC1, APEX1, PLEKHA4, CSTF3, ENPP3, nsp16, CIT, KIF14, RMDN3, NUPR1, PTP4A3, OGT, FILIP1, GRIN3B, LUZP1, WHAMMP3, C15orf59, CEP170P1, TMEM173, TBK1, LMO7,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DAPK3	chr19	3963877	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DAPK3	BRCA	chr19	3964285	3964285	C	T	Silent	p.A170	4
DAPK3	CESC	chr19	3964692	3964692	G	C	Silent		4
DAPK3	BLCA	chr19	3964647	3964647	G	A	Silent	p.I135I	4
DAPK3	LUAD	chr19	3964802	3964802	C	T	Missense_Mutation	p.E84K	3
DAPK3	LGG	chr19	3959164	3959164	C	T	Missense_Mutation	p.V434M	3
DAPK3	UCEC	chr19	3964960	3964960	C	T	Missense_Mutation	p.R31Q	3
DAPK3	LUAD	chr19	3964952	3964952	C	A	Missense_Mutation	p.G34C	3
DAPK3	COAD	chr19	3964300	3964300	C	T	Silent	p.A165A	2
DAPK3	BLCA	chr19	3959237	3959237	G	A	Silent	p.L409L	2
DAPK3	SKCM	chr19	3961032	3961032	G	A	Missense_Mutation	p.R253C	2
DAPK3	STAD	chr19	3961031	3961031	C	T	Missense_Mutation		2
DAPK3	SKCM	chr19	3964704	3964704	G	A	Silent	p.A116A	2
DAPK3	STAD	chr19	3964935	3964935	G	A	Silent		2
DAPK3	HNSC	chr19	3964913	3964913	G	A	Missense_Mutation	p.R47C	2
DAPK3	SKCM	chr19	3964923	3964923	G	A	Silent	p.F43F	2
DAPK3	STAD	chr19	3964978	3964978	G	A	Missense_Mutation	p.A25V	2
DAPK3	LUAD	chr19	3959300	3959300	G	A	Silent	p.T388T	2
DAPK3	HNSC	chr19	3964694	3964694	G	A	Missense_Mutation	p.L120F	2
DAPK3	LGG	chr19	3964267	3964267	G	C	Missense_Mutation		2
DAPK3	SKCM	chr19	3964251	3964251	C	T	Missense_Mutation	p.E182K	2
DAPK3	STAD	chr19	3964935	3964935	G	A	Silent	p.Y39Y	2
DAPK3	LGG	chr19	3964722	3964722	C	T	Silent		2
DAPK3	STAD	chr19	3961031	3961031	C	T	Missense_Mutation	p.R253H	2
DAPK3	UCEC	chr19	3964286	3964286	G	A	Missense_Mutation	p.A170V	2
DAPK3	CESC	chr19	3964677	3964677	G	A	Silent		2
DAPK3	HNSC	chr19	3964890	3964890	A	-	Frame_Shift_Del	p.R54fs	2
DAPK3	UCEC	chr19	3964297	3964297	G	A	Silent	p.H166	2
DAPK3	CESC	chr19	3964273	3964273	G	C	Missense_Mutation		2
DAPK3	STAD	chr19	3959148	3959148	C	T	Missense_Mutation	p.R439H	2
DAPK3	KIRP	chr19	3959444	3959444	G	A	Silent	p.R340R	2
DAPK3	UCEC	chr19	3964315	3964315	G	A	Silent	p.I160	2
DAPK3	STAD	chr19	3964830	3964830	G	-	Frame_Shift_Del	p.N75fs	2
DAPK3	CESC	chr19	3964264	3964264	G	C	Missense_Mutation		2
DAPK3	UCEC	chr19	3964675	3964675	C	T	Missense_Mutation	p.G126D	2
DAPK3	STAD	chr19	3964788	3964788	G	A	Silent	p.D88D	2
DAPK3	CESC	chr19	3964695	3964695	G	A	Silent		2
DAPK3	LGG	chr19	3964267	3964267	G	C	Missense_Mutation	p.N176K	2
DAPK3	UCEC	chr19	3964803	3964803	G	A	Silent	p.F83	2
DAPK3	STAD	chr19	3969677	3969677	C	T	Silent	p.L19L	2
DAPK3	HNSC	chr19	3964692	3964692	G	C	Silent	p.L120L	2
DAPK3	CESC	chr19	3964824	3964824	G	A	Silent		2
DAPK3	LGG	chr19	3964722	3964722	C	T	Silent	p.S110S	2
DAPK3	SKCM	chr19	3964974	3964974	G	A	Silent	p.I26I	2
DAPK3	STAD	chr19	3959300	3959300	G	A	Silent		1
DAPK3	STAD	chr19	3969700	3969700	G	A	Missense_Mutation	p.H12Y	1
DAPK3	HNSC	chr19	3964800	3964800	C	T	Silent	p.E84E	1
DAPK3	CESC	chr19	3964677	3964677	G	A	Silent	p.D125D	1
DAPK3	LGG	chr19	3964909	3964909	C	T	Missense_Mutation	p.R48H	1
DAPK3	COAD	chr19	3964906	3964906	A	G	Missense_Mutation	p.L49P	1
DAPK3	LUAD	chr19	3959178	3959178	G	A	Missense_Mutation	p.S429F	1
DAPK3	STAD	chr19	3959614	3959614	G	A	Missense_Mutation	p.R284C	1
DAPK3	BLCA	chr19	3969722	3969722	G	C	Missense_Mutation	p.F4L	1
DAPK3	HNSC	chr19	3964910	3964910	G	A	Missense_Mutation	p.R48C	1
DAPK3	CESC	chr19	3961074	3961074	C	C	Missense_Mutation		1
DAPK3	LGG	chr19	3964928	3964928	T	C	Missense_Mutation	p.K42E	1
DAPK3	GBM	chr19	3961153	3961153	G	A	Silent	p.S212S	1
DAPK3	LUAD	chr19	3960103	3960103	C	G	Splice_Site		1
DAPK3	STAD	chr19	3959269	3959271	CCT	-	In_Frame_Del	p.E398del	1
DAPK3	BLCA	chr19	3964871	3964871	T	C	Missense_Mutation	p.I61V	1
DAPK3	CESC	chr19	3964692	3964692	G	C	Silent	p.L120	1
DAPK3	GBM	chr19	3959627	3959627	C	T	Silent	p.R279R	1
DAPK3	LUSC	chr19	3959564	3959564	C	T	Silent	p.T300T	1
DAPK3	THCA	chr19	3964989	3964989	G	A	Silent		1
DAPK3	CESC	chr19	3964824	3964824	G	A	Silent	p.I76	1
DAPK3	HNSC	chr19	3964800	3964800	C	T	Silent		1
DAPK3	LUSC	chr19	3964897	3964897	C	A	Missense_Mutation	p.S52I	1
DAPK3	HNSC	chr19	3964740	3964740	G	A	Silent	p.F104F	1
DAPK3	CESC	chr19	3964677	3964677	G	A	Silent	p.D125	1
DAPK3	SKCM	chr19	3959143	3959143	G	A	Silent	p.L441L	1
DAPK3	HNSC	chr19	3964913	3964913	G	A	Missense_Mutation		1
DAPK3	LUSC	chr19	3959147	3959147	G	A	Silent	p.R439R	1
DAPK3	CESC	chr19	3959476	3959476	C	G	Missense_Mutation	p.E330Q	1
DAPK3	LGG	chr19	3959164	3959164	C	T	Missense_Mutation		1
DAPK3	SKCM	chr19	3961144	3961144	G	A	Silent	p.S215S	1
DAPK3	STAD	chr19	3959428	3959428	G	A	Missense_Mutation	p.R346W	1
DAPK3	BLCA	chr19	3964261	3964261	G	A	Silent		1
DAPK3	HNSC	chr19	3964890	3964890	A	-	Frame_Shift_Del		1
DAPK3	PRAD	chr19	3964791	3964791	C	T	Silent	p.T87T	1
DAPK3	KIRC	chr19	3964350	3964350	C	T	Missense_Mutation	p.D149N	1
DAPK3	CESC	chr19	3959554	3959554	C	T	Missense_Mutation	p.E304K	1
DAPK3	LGG	chr19	3964909	3964909	C	T	Missense_Mutation		1
DAPK3	SKCM	chr19	3959320	3959320	G	A	Missense_Mutation	p.R382W	1
DAPK3	BLCA	chr19	3964647	3964647	G	A	Silent		1
DAPK3	HNSC	chr19	3964740	3964740	G	A	Silent		1
DAPK3	CESC	chr19	3959554	3959554	C	T	Missense_Mutation		1
DAPK3	READ	chr19	3959259	3959259	G	A	Missense_Mutation	p.A402V	1
DAPK3	CESC	chr19	3964264	3964264	G	C	Missense_Mutation	p.I177M	1
DAPK3	LGG	chr19	3964928	3964928	T	C	Missense_Mutation		1
DAPK3	SKCM	chr19	3964360	3964360	G	A	Silent	p.I145I	1
DAPK3	BLCA	chr19	3959237	3959237	G	A	Silent		1
DAPK3	HNSC	chr19	3964694	3964694	G	A	Missense_Mutation		1
DAPK3	KIRP	chr19	3964284	3964284	C	A	Missense_Mutation		1
DAPK3	READ	chr19	3961014	3961014	C	A	Missense_Mutation	p.D259Y	1
DAPK3	CESC	chr19	3964273	3964273	G	C	Missense_Mutation	p.F174L	1
DAPK3	LIHC	chr19	3959236	3959236	T	C	Missense_Mutation	p.K410E	1
DAPK3	SKCM	chr19	3964824	3964824	G	A	Silent	p.I76I	1
DAPK3	BLCA	chr19	3964261	3964261	G	A	Silent	p.F178F	1
DAPK3	HNSC	chr19	3964910	3964910	G	A	Missense_Mutation		1
DAPK3	READ	chr19	3964332	3964332	G	T	Missense_Mutation	p.P155T	1
DAPK3	COAD	chr19	3959578	3959578	G	A	Missense_Mutation	p.R296C	1
DAPK3	STAD	chr19	3964978	3964978	G	A	Missense_Mutation		1

Copy number variation (CNV) of DAPK3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DAPK3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
51186	Non-Cancer	SPNT_312	ANKRD24	chr19	4210369	+	DAPK3	chr19	3964989	-
58786	N/A	BI045301	DAPK3	chr19	3964370	+	NFATC1	chr18	77272307	-
51186	Non-Cancer	TCGA-HU-A4GC-11A	FLNA	chrX	153581710	-	DAPK3	chr19	3958968	-
51186	N/A	BF526358	HNRNPA3	chr2	178084506	+	DAPK3	chr19	3965682	-
51194	STAD	TCGA-BR-4187-01A	MAP2K2	chr19	4123781	-	DAPK3	chr19	3969827	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	DAPK3	0.00513931142256868	0.14
LUAD	DAPK3	0.0063919918753831	0.17
THCA	DAPK3	0.036538271448227	0.95

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	DAPK3	0.035352071844917	1
LUSC	DAPK3	0.0246408519738189	0.79
LGG	DAPK3	0.0464118691747508	1
SKCM	DAPK3	0.000229038039499695	0.0076
THYM	DAPK3	0.0491427097298416	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
O43293	DB04716	2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one		Small molecule	Experimental
O43293	DB07125	4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid		Small molecule	Experimental
O43293	DB07242	(4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile		Small molecule	Experimental
O43293	DB04716	2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
O43293	DB07125	4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid
O43293	DB07242	(4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source