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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: DAZ1 (NCBI Gene ID:1617)


Gene Summary

check button Gene Summary
Gene InformationGene Name: DAZ1
Gene ID: 1617
Gene Symbol

DAZ1

Gene ID

1617

Gene Namedeleted in azoospermia 1
SynonymsDAZ|SPGY
Cytomap

Yq11.223

Type of Geneprotein-coding
Descriptiondeleted in azoospermia protein 1testicular tissue protein Li 49
Modification date20200313
UniProtAcc

Q9NQZ3


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0045727Positive regulation of translation
GO:0006413Translational initiation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAZ1

GO:0045948

positive regulation of translational initiation

16001084



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'DAZ1[title] AND translation [title] AND human.'
GeneTitlePMID
DAZ1..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST0000040523925281321252814205CDS-5UTR
ENST000004052392528915725289229In-frame
ENST000004052392530849525308567In-frame

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST000004052392528915725289229443822872358744762786
ENST000004052392528915725289229443822872358744762786
ENST000004052392528915725289229443822872358744762786
ENST000004052392528915725289229443822872358744762786
ENST000004052392528915725289229443822872358744762786
ENST000004052392530849525308567443819271998744642666
ENST000004052392530849525308567443819271998744642666
ENST000004052392530849525308567443819271998744642666
ENST000004052392530849525308567443819271998744642666

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
Q9NQZ36426661744ChainID=PRO_0000081554;Note=Deleted in azoospermia protein 1
Q9NQZ36426661744ChainID=PRO_0000081554;Note=Deleted in azoospermia protein 1
Q9NQZ36426661744ChainID=PRO_0000081554;Note=Deleted in azoospermia protein 1
Q9NQZ36426661744ChainID=PRO_0000081554;Note=Deleted in azoospermia protein 1
Q9NQZ3642666644664DomainNote=DAZ-like 7
Q9NQZ3642666644664DomainNote=DAZ-like 7
Q9NQZ3642666644664DomainNote=DAZ-like 7
Q9NQZ3642666644664DomainNote=DAZ-like 7
Q9NQZ3642666614744Alternative sequenceID=VSP_056240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9NQZ3642666614744Alternative sequenceID=VSP_056240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9NQZ3642666614744Alternative sequenceID=VSP_056240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9NQZ3642666614744Alternative sequenceID=VSP_056240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
LUADDAZ1-1.777998569285290.00166169445798351


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue
CHOLDAZ1hsa-miR-340-5p51-0.3180939079218840.0332172889089468


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
Cancer typeGeneCoefficientPvalue

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with DAZ1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
DLBCCell metabolism geneDAZ1GSTA30.821738178.22E-13
DLBCCell metabolism geneDAZ1GPX20.840359298.04E-14
DLBCCell metabolism geneDAZ1LIPF0.8571494547.55E-15
DLBCCell metabolism geneDAZ1MUC60.8733634615.67E-16
DLBCCell metabolism geneDAZ1AKR1B100.909945263.35E-19
DLBCCGCDAZ1SOX210.8533911141.31E-14
DLBCIUPHARDAZ1CCKAR0.8247358055.76E-13
DLBCIUPHARDAZ1SLC28A20.827297144.23E-13
DLBCIUPHARDAZ1LIPF0.8571494547.55E-15
DLBCIUPHARDAZ1CPA20.8743661484.77E-16
DLBCIUPHARDAZ1CLDN180.8813243771.39E-16
DLBCIUPHARDAZ1PGC0.9301681581.20E-21
DLBCTFDAZ1FOXA20.8004506298.61E-12
DLBCTFDAZ1SOX210.8533911141.31E-14
DLBCTSGDAZ1FOXA20.8004506298.61E-12
DLBCTSGDAZ1SPINK70.821738178.22E-13
DLBCTSGDAZ1GKN20.8830933161.00E-16
DLBCTSGDAZ1GKN10.921513471.61E-20


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with DAZ1
DAZL, DAZAP1, DAZAP2, DAZ1, PUM2, QKI, BOLL, DZIP1, DZIP1L, DZIP3,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples

check buttonCopy number variation (CNV) of DAZ1
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across DAZ1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
N/ADL059445DAZ1chrY25309848-ATP8B5Pchr935415374-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
MESODAZ10.01774846184631510.071
CHOLDAZ11.19175586026943e-071.3e-06
KIRPDAZ11.21914653038308e-081.5e-07
LUSCDAZ11.3299985475017e-152.4e-14
STADDAZ11.43062024992895e-443.7e-43
SKCMDAZ11.46129402525315e-393.5e-38
UVMDAZ11.59289225010666e-058e-05
HNSCDAZ11.59567054715989e-112.2e-10
SARCDAZ11.72092809077965e-122.8e-11
PAADDAZ11.83524960814611e-153.1e-14
KIRCDAZ11.89106423731516e-705.3e-69
READDAZ11.94329240081062e-071.9e-06
COADDAZ12.5747645280155e-123.9e-11
PCPGDAZ12.80921578918736e-185.3e-17
KICHDAZ13.08625753627346e-062.2e-05
GBMDAZ13.1829303862754e-094.1e-08
ESCADAZ13.66441250196871e-073.3e-06
ACCDAZ13.79883978056518e-062.3e-05
THCADAZ14.2344091133948e-329.3e-31
BRCADAZ14.79353138923888e-531.3e-51
LUADDAZ15.67354751981317e-311.2e-29
LIHCDAZ15.80166717602461e-331.3e-31
LGGDAZ17.71137416782363e-411.9e-39
THYMDAZ18.56794411550787e-076.9e-06
BLCADAZ19.55425525544411e-241.9e-22

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
THCADAZ10.01527042059719520.46
KIRCDAZ10.008118737083152410.26
GBMDAZ10.01538778749059090.46
BLCADAZ10.02736789985342720.77
HNSCDAZ10.01361200108433160.42
READDAZ10.03660257432326020.99

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source