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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DDX1 (NCBI Gene ID:1653)

Gene Summary

Gene Summary

Gene Information	Gene Name: DDX1
	Gene ID: 1653
	Gene Symbol	DDX1
	Gene ID	1653
	Gene Name	DEAD-box helicase 1
	Synonyms	DBP-RB\|UKVH5d
	Cytomap	2p24.3
	Type of Gene	protein-coding
	Description	ATP-dependent RNA helicase DDX1DEAD (Asp-Glu-Ala-Asp) box helicase 1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1DEAD box polypeptide 1DEAD box protein 1DEAD box protein retinoblastomaDEAD box-1DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1DEAD/H-box h
	Modification date	20200313
	UniProtAcc	Q92499

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DDX1	GO:0006302	double-strand break repair	18710941
Hgene	DDX1	GO:0032508	DNA duplex unwinding	18710941
Hgene	DDX1	GO:0090305	nucleic acid phosphodiester bond hydrolysis	18710941

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DDX1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'DDX1[title] AND translation [title] AND human.'

Gene	Title	PMID
DDX1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000233084	15735268	15735320	Frame-shift
ENST00000381341	15735268	15735320	Frame-shift
ENST00000233084	15736857	15736887	In-frame
ENST00000381341	15736857	15736887	In-frame
ENST00000233084	15742671	15742755	In-frame
ENST00000381341	15742671	15742755	In-frame
ENST00000233084	15747298	15747437	Frame-shift
ENST00000381341	15747298	15747437	Frame-shift
ENST00000233084	15753347	15753408	Frame-shift
ENST00000381341	15753347	15753408	Frame-shift
ENST00000233084	15757367	15757466	In-frame
ENST00000381341	15757367	15757466	In-frame
ENST00000233084	15760331	15760520	In-frame
ENST00000381341	15760331	15760520	In-frame
ENST00000233084	15761188	15761240	Frame-shift
ENST00000381341	15761188	15761240	Frame-shift
ENST00000233084	15768568	15768641	Frame-shift
ENST00000381341	15768568	15768641	Frame-shift
ENST00000233084	15768920	15768963	Frame-shift
ENST00000381341	15768920	15768963	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000233084	15736857	15736887	2723	421	450	740	44	54
ENST00000381341	15736857	15736887	2834	522	551	740	44	54
ENST00000233084	15742671	15742755	2723	596	679	740	102	130
ENST00000381341	15742671	15742755	2834	697	780	740	102	130
ENST00000233084	15757367	15757466	2723	1306	1404	740	339	372
ENST00000381341	15757367	15757466	2834	1407	1505	740	339	372
ENST00000233084	15760331	15760520	2723	1495	1683	740	402	465
ENST00000381341	15760331	15760520	2834	1596	1784	740	402	465

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q92499	339	372	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
Q92499	102	130	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
Q92499	44	54	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
Q92499	402	465	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
Q92499	339	372	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
Q92499	102	130	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
Q92499	44	54	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
Q92499	402	465	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
Q92499	339	372	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q92499	102	130	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q92499	44	54	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q92499	402	465	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q92499	339	372	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q92499	102	130	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q92499	44	54	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q92499	402	465	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q92499	102	130	70	247	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00548
Q92499	102	130	70	247	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00548
Q92499	44	54	46	53	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92499	44	54	46	53	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q92499	339	372	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19058135;Dbxref=PMID:19058135
Q92499	102	130	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19058135;Dbxref=PMID:19058135
Q92499	44	54	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19058135;Dbxref=PMID:19058135
Q92499	402	465	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19058135;Dbxref=PMID:19058135
Q92499	339	372	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19058135;Dbxref=PMID:19058135
Q92499	102	130	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19058135;Dbxref=PMID:19058135
Q92499	44	54	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19058135;Dbxref=PMID:19058135
Q92499	402	465	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19058135;Dbxref=PMID:19058135
Q92499	339	372	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q91VR5
Q92499	102	130	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q91VR5
Q92499	44	54	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q91VR5
Q92499	402	465	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q91VR5
Q92499	339	372	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q91VR5
Q92499	102	130	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q91VR5
Q92499	44	54	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q91VR5
Q92499	402	465	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q91VR5
Q92499	102	130	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12183465;Dbxref=PMID:12183465
Q92499	44	54	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12183465;Dbxref=PMID:12183465
Q92499	102	130	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12183465;Dbxref=PMID:12183465
Q92499	44	54	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12183465;Dbxref=PMID:12183465
Q92499	339	372	370	373	Motif	Note=DEAD box
Q92499	339	372	370	373	Motif	Note=DEAD box
Q92499	102	130	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q92499	44	54	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q92499	102	130	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q92499	44	54	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q92499	102	130	98	113	Alternative sequence	ID=VSP_055454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q92499	102	130	98	113	Alternative sequence	ID=VSP_055454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q92499	44	54	52	52	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24870230;Dbxref=PMID:24870230
Q92499	44	54	52	52	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:24870230;Dbxref=PMID:24870230
Q92499	339	372	371	371	Mutagenesis	Note=Inhibits the transcriptional activity of RELA and attenuates NF-kappa-B-mediated gene expression. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:19058135,ECO:0000269\|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
Q92499	339	372	371	371	Mutagenesis	Note=Inhibits the transcriptional activity of RELA and attenuates NF-kappa-B-mediated gene expression. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:19058135,ECO:0000269\|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
Q92499	339	372	371	371	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:19058135,ECO:0000269\|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
Q92499	339	372	371	371	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:19058135,ECO:0000269\|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
Q92499	102	130	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XW3
Q92499	102	130	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XW3
Q92499	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XW3
Q92499	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XW3
Q92499	102	130	120	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XW3
Q92499	102	130	120	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XW3

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
HNSC	DDX1	-1.93264777047709	0.00148187079003037
LUAD	DDX1	-1.61550836542382	1.45287170087739e-05
KIRC	DDX1	-4.01417090847751	2.90348670181982e-08
THCA	DDX1	-2.14439797401062	9.38064110141239e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUSC	DDX1	-0.162583995	0.001947307
LIHC	DDX1	0.063909696	0.00877608
SARC	DDX1	-0.270265708	0.020600634

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DDX1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	Epifactor	DDX1	HAT1	0.819840813	2.87E-23
KICH	IUPHAR	DDX1	HAT1	0.819840813	2.87E-23
KICH	TSG	DDX1	XRCC5	0.822415528	1.61E-23
LAML	Cell metabolism gene	DDX1	NUP133	0.810553012	1.39E-41
LAML	Cell metabolism gene	DDX1	HSPD1	0.815400464	1.89E-42
LAML	Cell metabolism gene	DDX1	EPRS	0.852445235	4.91E-50
LAML	TF	DDX1	CEBPZ	0.847290706	7.33E-49
LAML	TSG	DDX1	HSPD1	0.815400464	1.89E-42
UVM	Cell metabolism gene	DDX1	MANEA	0.800282174	5.28E-19
UVM	Cell metabolism gene	DDX1	CALM2	0.801021202	4.64E-19
UVM	Cell metabolism gene	DDX1	ACSL3	0.803603229	2.94E-19
UVM	Cell metabolism gene	DDX1	MGAT2	0.804104829	2.69E-19
UVM	Cell metabolism gene	DDX1	PITPNB	0.805094237	2.25E-19
UVM	Cell metabolism gene	DDX1	ALG13	0.805311418	2.16E-19
UVM	Cell metabolism gene	DDX1	RAP1B	0.806565428	1.73E-19
UVM	Cell metabolism gene	DDX1	PNPLA8	0.807204132	1.54E-19
UVM	Cell metabolism gene	DDX1	NAMPT	0.807577225	1.44E-19
UVM	Cell metabolism gene	DDX1	CNOT2	0.807982427	1.33E-19
UVM	Cell metabolism gene	DDX1	PSMD12	0.808546	1.20E-19
UVM	Cell metabolism gene	DDX1	FAR1	0.808647762	1.18E-19
UVM	Cell metabolism gene	DDX1	HIF1A	0.808699982	1.17E-19
UVM	Cell metabolism gene	DDX1	SRP54	0.809618288	9.88E-20
UVM	Cell metabolism gene	DDX1	DLD	0.809801474	9.55E-20
UVM	Cell metabolism gene	DDX1	PLA2G12A	0.809924643	9.34E-20
UVM	Cell metabolism gene	DDX1	GRPEL2	0.810946143	7.72E-20
UVM	Cell metabolism gene	DDX1	AZIN1	0.813123014	5.14E-20
UVM	Cell metabolism gene	DDX1	ARFGEF2	0.813342308	4.93E-20
UVM	Cell metabolism gene	DDX1	GLUD1	0.813700307	4.61E-20
UVM	Cell metabolism gene	DDX1	NUPL1	0.81380585	4.52E-20
UVM	Cell metabolism gene	DDX1	PIKFYVE	0.814613257	3.88E-20
UVM	Cell metabolism gene	DDX1	GNPDA2	0.815257291	3.43E-20
UVM	Cell metabolism gene	DDX1	IDI1	0.819553818	1.49E-20
UVM	Cell metabolism gene	DDX1	DLAT	0.821508123	1.02E-20
UVM	Cell metabolism gene	DDX1	PAFAH1B1	0.821821101	9.56E-21
UVM	Cell metabolism gene	DDX1	NUDT12	0.82297066	7.60E-21
UVM	Cell metabolism gene	DDX1	UGGT2	0.823818159	6.41E-21
UVM	Cell metabolism gene	DDX1	UPRT	0.825005173	5.04E-21
UVM	Cell metabolism gene	DDX1	MDH1	0.825087621	4.96E-21
UVM	Cell metabolism gene	DDX1	HMGCS1	0.825538471	4.53E-21
UVM	Cell metabolism gene	DDX1	SACM1L	0.825675044	4.40E-21
UVM	Cell metabolism gene	DDX1	SGPP1	0.8270318	3.34E-21
UVM	Cell metabolism gene	DDX1	UGP2	0.827515241	3.02E-21
UVM	Cell metabolism gene	DDX1	PIK3C2A	0.827993304	2.74E-21
UVM	Cell metabolism gene	DDX1	ALG10B	0.829507528	2.00E-21
UVM	Cell metabolism gene	DDX1	CLOCK	0.830020519	1.80E-21
UVM	Cell metabolism gene	DDX1	PGM2	0.832702763	1.02E-21
UVM	Cell metabolism gene	DDX1	PRKAA1	0.833513473	8.57E-22
UVM	Cell metabolism gene	DDX1	PANK3	0.834554037	6.85E-22
UVM	Cell metabolism gene	DDX1	PSMA4	0.836764966	4.24E-22
UVM	Cell metabolism gene	DDX1	TGS1	0.836766604	4.24E-22
UVM	Cell metabolism gene	DDX1	PHAX	0.836895555	4.12E-22
UVM	Cell metabolism gene	DDX1	RANBP2	0.837924315	3.29E-22
UVM	Cell metabolism gene	DDX1	POLR2B	0.838249803	3.06E-22
UVM	Cell metabolism gene	DDX1	VAPA	0.838387147	2.97E-22
UVM	Cell metabolism gene	DDX1	EPT1	0.843323728	9.77E-23
UVM	Cell metabolism gene	DDX1	AGPS	0.843602489	9.17E-23
UVM	Cell metabolism gene	DDX1	VBP1	0.843808019	8.74E-23
UVM	Cell metabolism gene	DDX1	NUPL2	0.843896729	8.57E-23
UVM	Cell metabolism gene	DDX1	PPAT	0.844321816	7.77E-23
UVM	Cell metabolism gene	DDX1	LYPLA1	0.845644914	5.72E-23
UVM	Cell metabolism gene	DDX1	PPP1CB	0.846890315	4.27E-23
UVM	Cell metabolism gene	DDX1	DIS3	0.84808861	3.22E-23
UVM	Cell metabolism gene	DDX1	EDEM3	0.848841716	2.69E-23
UVM	Cell metabolism gene	DDX1	MCEE	0.849506951	2.30E-23
UVM	Cell metabolism gene	DDX1	SRP72	0.849633029	2.23E-23
UVM	Cell metabolism gene	DDX1	PIK3C3	0.852925133	1.00E-23
UVM	Cell metabolism gene	DDX1	HMGCR	0.855278336	5.61E-24
UVM	Cell metabolism gene	DDX1	NUP107	0.855667572	5.09E-24
UVM	Cell metabolism gene	DDX1	MED17	0.856311305	4.33E-24
UVM	Cell metabolism gene	DDX1	TNPO1	0.856441333	4.19E-24
UVM	Cell metabolism gene	DDX1	GPD2	0.857617992	3.11E-24
UVM	Cell metabolism gene	DDX1	SPTLC1	0.858700676	2.36E-24
UVM	Cell metabolism gene	DDX1	NUP50	0.859019298	2.18E-24
UVM	Cell metabolism gene	DDX1	CNOT8	0.861074989	1.28E-24
UVM	Cell metabolism gene	DDX1	MTMR6	0.861547295	1.13E-24
UVM	Cell metabolism gene	DDX1	BPNT1	0.863009301	7.69E-25
UVM	Cell metabolism gene	DDX1	PSME4	0.86323551	7.24E-25
UVM	Cell metabolism gene	DDX1	SEH1L	0.868956366	1.53E-25
UVM	Cell metabolism gene	DDX1	CCT2	0.886417267	8.17E-28
UVM	Cell metabolism gene	DDX1	LCLAT1	0.895658925	3.58E-29
UVM	Cell metabolism gene	DDX1	PSMC6	0.897376248	1.94E-29
UVM	Cell metabolism gene	DDX1	PSMD14	0.898523106	1.28E-29
UVM	Cell metabolism gene	DDX1	XPO1	0.919839519	1.96E-33
UVM	CGC	DDX1	PWWP2A	0.800893503	4.75E-19
UVM	CGC	DDX1	EML4	0.801709421	4.11E-19
UVM	CGC	DDX1	BIRC6	0.802246027	3.74E-19
UVM	CGC	DDX1	ACSL3	0.803603229	2.94E-19
UVM	CGC	DDX1	HIF1A	0.808699982	1.17E-19
UVM	CGC	DDX1	EZH2	0.814114006	4.26E-20
UVM	CGC	DDX1	BCLAF1	0.815882655	3.04E-20
UVM	CGC	DDX1	SMARCE1	0.817997349	2.02E-20
UVM	CGC	DDX1	ABI1	0.81993563	1.39E-20
UVM	CGC	DDX1	USP8	0.823082906	7.43E-21
UVM	CGC	DDX1	NFE2L2	0.82448176	5.61E-21
UVM	CGC	DDX1	ARID2	0.82476292	5.30E-21
UVM	CGC	DDX1	SMAD4	0.825816936	4.28E-21
UVM	CGC	DDX1	HNRNPA2B1	0.825912806	4.19E-21
UVM	CGC	DDX1	DDX5	0.827738971	2.88E-21
UVM	CGC	DDX1	ZMYM2	0.831003418	1.46E-21
UVM	CGC	DDX1	KIF5B	0.831463444	1.33E-21
UVM	CGC	DDX1	MAP2K4	0.83533036	5.80E-22
UVM	CGC	DDX1	RANBP2	0.837924315	3.29E-22
UVM	CGC	DDX1	FIP1L1	0.839941492	2.10E-22
UVM	CGC	DDX1	STAG2	0.841626821	1.44E-22
UVM	CGC	DDX1	GOLGA5	0.841673482	1.42E-22
UVM	CGC	DDX1	TCF12	0.847090495	4.08E-23
UVM	CGC	DDX1	HSP90AA1	0.847431058	3.76E-23
UVM	CGC	DDX1	BAZ1A	0.849940971	2.07E-23
UVM	CGC	DDX1	CREB1	0.851065312	1.58E-23
UVM	CGC	DDX1	CDC73	0.851548771	1.41E-23
UVM	CGC	DDX1	RAD21	0.855402273	5.44E-24
UVM	CGC	DDX1	POT1	0.858496908	2.49E-24
UVM	CGC	DDX1	RABEP1	0.860673231	1.42E-24
UVM	CGC	DDX1	BMPR1A	0.860740142	1.40E-24
UVM	CGC	DDX1	SUZ12	0.862266695	9.36E-25
UVM	CGC	DDX1	SF3B1	0.868088824	1.95E-25
UVM	CGC	DDX1	PMS1	0.877284399	1.39E-26
UVM	CGC	DDX1	MSH2	0.879446913	7.28E-27
UVM	CGC	DDX1	CUL3	0.879810828	6.51E-27
UVM	CGC	DDX1	ATM	0.886430458	8.14E-28
UVM	CGC	DDX1	FBXO11	0.914051194	2.65E-32
UVM	CGC	DDX1	XPO1	0.919839519	1.96E-33
UVM	Epifactor	DDX1	ANP32E	0.804145595	2.67E-19
UVM	Epifactor	DDX1	RCOR3	0.806730682	1.68E-19
UVM	Epifactor	DDX1	NIPBL	0.807525122	1.45E-19
UVM	Epifactor	DDX1	H2AFV	0.808954789	1.12E-19
UVM	Epifactor	DDX1	USP15	0.810078146	9.07E-20
UVM	Epifactor	DDX1	CDK17	0.812474308	5.81E-20
UVM	Epifactor	DDX1	INO80D	0.812480211	5.80E-20
UVM	Epifactor	DDX1	PCGF6	0.813927322	4.42E-20
UVM	Epifactor	DDX1	CTBP2	0.813936344	4.41E-20
UVM	Epifactor	DDX1	EZH2	0.814114006	4.26E-20
UVM	Epifactor	DDX1	BAZ2B	0.814702728	3.81E-20
UVM	Epifactor	DDX1	SMARCE1	0.817997349	2.02E-20
UVM	Epifactor	DDX1	TAF5	0.81832333	1.90E-20
UVM	Epifactor	DDX1	ZBTB33	0.819057652	1.65E-20
UVM	Epifactor	DDX1	SUPT7L	0.821039816	1.12E-20
UVM	Epifactor	DDX1	ARID2	0.82476292	5.30E-21
UVM	Epifactor	DDX1	TAF2	0.825920969	4.19E-21
UVM	Epifactor	DDX1	ARID4A	0.826818338	3.49E-21
UVM	Epifactor	DDX1	BRMS1L	0.827525928	3.01E-21
UVM	Epifactor	DDX1	CHD9	0.828232964	2.60E-21
UVM	Epifactor	DDX1	CLOCK	0.830020519	1.80E-21
UVM	Epifactor	DDX1	TADA1	0.830901148	1.49E-21
UVM	Epifactor	DDX1	ZMYM2	0.831003418	1.46E-21
UVM	Epifactor	DDX1	CUL5	0.832205986	1.13E-21
UVM	Epifactor	DDX1	PRKAA1	0.833513473	8.57E-22
UVM	Epifactor	DDX1	RLIM	0.834275251	7.28E-22
UVM	Epifactor	DDX1	EPC1	0.835563343	5.51E-22
UVM	Epifactor	DDX1	TDG	0.837610692	3.52E-22
UVM	Epifactor	DDX1	JMJD1C	0.838015265	3.22E-22
UVM	Epifactor	DDX1	EPC2	0.838239418	3.07E-22
UVM	Epifactor	DDX1	YEATS4	0.842824437	1.10E-22
UVM	Epifactor	DDX1	ATAD2B	0.842889027	1.08E-22
UVM	Epifactor	DDX1	HMGB1	0.846777407	4.39E-23
UVM	Epifactor	DDX1	SMARCA5	0.847311409	3.87E-23
UVM	Epifactor	DDX1	BAZ1A	0.849940971	2.07E-23
UVM	Epifactor	DDX1	CBX3	0.850182172	1.96E-23
UVM	Epifactor	DDX1	SIRT1	0.851361583	1.47E-23
UVM	Epifactor	DDX1	CDC73	0.851548771	1.41E-23
UVM	Epifactor	DDX1	BRCC3	0.855718471	5.03E-24
UVM	Epifactor	DDX1	UCHL5	0.856326221	4.32E-24
UVM	Epifactor	DDX1	NSL1	0.857091187	3.56E-24
UVM	Epifactor	DDX1	YY1	0.857462679	3.24E-24
UVM	Epifactor	DDX1	SMEK1	0.857567679	3.15E-24
UVM	Epifactor	DDX1	ATF2	0.858535474	2.46E-24
UVM	Epifactor	DDX1	ZRANB3	0.858573972	2.44E-24
UVM	Epifactor	DDX1	PARG	0.861217614	1.23E-24
UVM	Epifactor	DDX1	SUZ12	0.862266695	9.36E-25
UVM	Epifactor	DDX1	PHF20L1	0.862617658	8.53E-25
UVM	Epifactor	DDX1	VRK1	0.866172484	3.29E-25
UVM	Epifactor	DDX1	FAM175B	0.866839688	2.75E-25
UVM	Epifactor	DDX1	SF3B1	0.868088824	1.95E-25
UVM	Epifactor	DDX1	RAD54B	0.86853205	1.72E-25
UVM	Epifactor	DDX1	AEBP2	0.874346745	3.31E-26
UVM	Epifactor	DDX1	MASTL	0.878423034	9.92E-27
UVM	Epifactor	DDX1	TAF7	0.878799912	8.85E-27
UVM	Epifactor	DDX1	CUL3	0.879810828	6.51E-27
UVM	Epifactor	DDX1	HAT1	0.880822897	4.78E-27
UVM	Epifactor	DDX1	CUL2	0.883285357	2.22E-27
UVM	Epifactor	DDX1	TLK1	0.886050296	9.20E-28
UVM	Epifactor	DDX1	ATM	0.886430458	8.14E-28
UVM	Epifactor	DDX1	ACTR6	0.901052354	5.01E-30
UVM	Epifactor	DDX1	SMEK2	0.914262476	2.42E-32
UVM	IUPHAR	DDX1	PRPF4B	0.80059718	5.00E-19
UVM	IUPHAR	DDX1	IRAK4	0.801016265	4.64E-19
UVM	IUPHAR	DDX1	BIRC6	0.802246027	3.74E-19
UVM	IUPHAR	DDX1	KIF11	0.803043137	3.25E-19
UVM	IUPHAR	DDX1	TMEM165	0.803990439	2.74E-19
UVM	IUPHAR	DDX1	ULK2	0.804888836	2.34E-19
UVM	IUPHAR	DDX1	ATP6V1C1	0.806898463	1.63E-19
UVM	IUPHAR	DDX1	ATP6V0A2	0.808710328	1.17E-19
UVM	IUPHAR	DDX1	SLC25A46	0.808878712	1.13E-19
UVM	IUPHAR	DDX1	RIOK3	0.80927103	1.05E-19
UVM	IUPHAR	DDX1	STK3	0.809830296	9.50E-20
UVM	IUPHAR	DDX1	PLA2G12A	0.809924643	9.34E-20
UVM	IUPHAR	DDX1	STK17A	0.810487774	8.41E-20
UVM	IUPHAR	DDX1	CDK17	0.812474308	5.81E-20
UVM	IUPHAR	DDX1	TRPM7	0.813460367	4.82E-20
UVM	IUPHAR	DDX1	EZH2	0.814114006	4.26E-20
UVM	IUPHAR	DDX1	PIKFYVE	0.814613257	3.88E-20
UVM	IUPHAR	DDX1	BAZ2B	0.814702728	3.81E-20
UVM	IUPHAR	DDX1	SRPK2	0.81507098	3.55E-20
UVM	IUPHAR	DDX1	EGLN1	0.81763925	2.17E-20
UVM	IUPHAR	DDX1	IDI1	0.819553818	1.49E-20
UVM	IUPHAR	DDX1	ADAM10	0.822612678	8.16E-21
UVM	IUPHAR	DDX1	NR2C1	0.822613333	8.16E-21
UVM	IUPHAR	DDX1	MARK3	0.822677147	8.06E-21
UVM	IUPHAR	DDX1	NFE2L2	0.82448176	5.61E-21
UVM	IUPHAR	DDX1	HMGCS1	0.825538471	4.53E-21
UVM	IUPHAR	DDX1	TNKS2	0.825906266	4.20E-21
UVM	IUPHAR	DDX1	SGPP1	0.8270318	3.34E-21
UVM	IUPHAR	DDX1	PIK3C2A	0.827993304	2.74E-21
UVM	IUPHAR	DDX1	BMPR2	0.828266605	2.59E-21
UVM	IUPHAR	DDX1	TAOK3	0.828437004	2.50E-21
UVM	IUPHAR	DDX1	ATP2B1	0.828854931	2.29E-21
UVM	IUPHAR	DDX1	CLOCK	0.830020519	1.80E-21
UVM	IUPHAR	DDX1	PRKAA1	0.833513473	8.57E-22
UVM	IUPHAR	DDX1	MAP2K4	0.83533036	5.80E-22
UVM	IUPHAR	DDX1	SLC30A5	0.836996228	4.03E-22
UVM	IUPHAR	DDX1	NAPEPLD	0.837094726	3.94E-22
UVM	IUPHAR	DDX1	JMJD1C	0.838015265	3.22E-22
UVM	IUPHAR	DDX1	MAPK6	0.838218893	3.08E-22
UVM	IUPHAR	DDX1	RIOK2	0.840429297	1.88E-22
UVM	IUPHAR	DDX1	SLC30A6	0.841565416	1.46E-22
UVM	IUPHAR	DDX1	ATAD2B	0.842889027	1.08E-22
UVM	IUPHAR	DDX1	XIAP	0.843503432	9.38E-23
UVM	IUPHAR	DDX1	PPAT	0.844321816	7.77E-23
UVM	IUPHAR	DDX1	TBK1	0.844371401	7.68E-23
UVM	IUPHAR	DDX1	HSP90AA1	0.847431058	3.76E-23
UVM	IUPHAR	DDX1	IDE	0.848656578	2.82E-23
UVM	IUPHAR	DDX1	BAZ1A	0.849940971	2.07E-23
UVM	IUPHAR	DDX1	SIRT1	0.851361583	1.47E-23
UVM	IUPHAR	DDX1	PIK3C3	0.852925133	1.00E-23
UVM	IUPHAR	DDX1	HMGCR	0.855278336	5.61E-24
UVM	IUPHAR	DDX1	SPTLC1	0.858700676	2.36E-24
UVM	IUPHAR	DDX1	BMPR1A	0.860740142	1.40E-24
UVM	IUPHAR	DDX1	USP14	0.861170688	1.25E-24
UVM	IUPHAR	DDX1	SLC30A9	0.864863292	4.69E-25
UVM	IUPHAR	DDX1	VRK1	0.866172484	3.29E-25
UVM	IUPHAR	DDX1	PLK4	0.867888249	2.06E-25
UVM	IUPHAR	DDX1	MAGT1	0.87669304	1.66E-26
UVM	IUPHAR	DDX1	MASTL	0.878423034	9.92E-27
UVM	IUPHAR	DDX1	VRK2	0.880198179	5.79E-27
UVM	IUPHAR	DDX1	HAT1	0.880822897	4.78E-27
UVM	IUPHAR	DDX1	PRMT3	0.88391236	1.82E-27
UVM	IUPHAR	DDX1	ABCB10	0.884826659	1.36E-27
UVM	IUPHAR	DDX1	TLK1	0.886050296	9.20E-28
UVM	IUPHAR	DDX1	ATM	0.886430458	8.14E-28
UVM	IUPHAR	DDX1	ADAM17	0.890207811	2.34E-28
UVM	IUPHAR	DDX1	MAP4K3	0.89346188	7.72E-29
UVM	IUPHAR	DDX1	PSMD14	0.898523106	1.28E-29
UVM	IUPHAR	DDX1	FBXO11	0.914051194	2.65E-32
UVM	IUPHAR	DDX1	XPO1	0.919839519	1.96E-33
UVM	Kinase	DDX1	PRPF4B	0.80059718	5.00E-19
UVM	Kinase	DDX1	IRAK4	0.801016265	4.64E-19
UVM	Kinase	DDX1	ULK2	0.804888836	2.34E-19
UVM	Kinase	DDX1	RIOK3	0.80927103	1.05E-19
UVM	Kinase	DDX1	STK3	0.809830296	9.50E-20
UVM	Kinase	DDX1	STK17A	0.810487774	8.41E-20
UVM	Kinase	DDX1	CDK17	0.812474308	5.81E-20
UVM	Kinase	DDX1	TRPM7	0.813460367	4.82E-20
UVM	Kinase	DDX1	SRPK2	0.81507098	3.55E-20
UVM	Kinase	DDX1	MARK3	0.822677147	8.06E-21
UVM	Kinase	DDX1	BMPR2	0.828266605	2.59E-21
UVM	Kinase	DDX1	TAOK3	0.828437004	2.50E-21
UVM	Kinase	DDX1	PRKAA1	0.833513473	8.57E-22
UVM	Kinase	DDX1	MAP2K4	0.83533036	5.80E-22
UVM	Kinase	DDX1	MAPK6	0.838218893	3.08E-22
UVM	Kinase	DDX1	RIOK2	0.840429297	1.88E-22
UVM	Kinase	DDX1	TBK1	0.844371401	7.68E-23
UVM	Kinase	DDX1	BAZ1A	0.849940971	2.07E-23
UVM	Kinase	DDX1	BMPR1A	0.860740142	1.40E-24
UVM	Kinase	DDX1	VRK1	0.866172484	3.29E-25
UVM	Kinase	DDX1	PLK4	0.867888249	2.06E-25
UVM	Kinase	DDX1	MASTL	0.878423034	9.92E-27
UVM	Kinase	DDX1	VRK2	0.880198179	5.79E-27
UVM	Kinase	DDX1	TLK1	0.886050296	9.20E-28
UVM	Kinase	DDX1	ATM	0.886430458	8.14E-28
UVM	Kinase	DDX1	MAP4K3	0.89346188	7.72E-29
UVM	TF	DDX1	THAP9	0.800049738	5.50E-19
UVM	TF	DDX1	MYBL1	0.800276362	5.29E-19
UVM	TF	DDX1	ZNF41	0.803089855	3.22E-19
UVM	TF	DDX1	ZC3H8	0.803800112	2.84E-19
UVM	TF	DDX1	DMTF1	0.804665989	2.43E-19
UVM	TF	DDX1	ZNF410	0.805045635	2.27E-19
UVM	TF	DDX1	ZNF14	0.807307888	1.51E-19
UVM	TF	DDX1	BACH1	0.80733592	1.50E-19
UVM	TF	DDX1	ZNF200	0.807708507	1.40E-19
UVM	TF	DDX1	VEZF1	0.808213278	1.28E-19
UVM	TF	DDX1	LIN54	0.808334824	1.25E-19
UVM	TF	DDX1	HIF1A	0.808699982	1.17E-19
UVM	TF	DDX1	ZNF280D	0.808909334	1.13E-19
UVM	TF	DDX1	THAP6	0.809734232	9.67E-20
UVM	TF	DDX1	ZNF585B	0.810404878	8.54E-20
UVM	TF	DDX1	ZNF268	0.81049638	8.40E-20
UVM	TF	DDX1	ZNF468	0.810713933	8.07E-20
UVM	TF	DDX1	CREBZF	0.811086542	7.53E-20
UVM	TF	DDX1	ZNF195	0.811197999	7.37E-20
UVM	TF	DDX1	ZNF449	0.811475774	7.00E-20
UVM	TF	DDX1	ZNF267	0.812355197	5.94E-20
UVM	TF	DDX1	ZNF182	0.812836904	5.42E-20
UVM	TF	DDX1	ZNF26	0.812937451	5.32E-20
UVM	TF	DDX1	ZNF555	0.813372506	4.90E-20
UVM	TF	DDX1	PCGF6	0.813927322	4.42E-20
UVM	TF	DDX1	BAZ2B	0.814702728	3.81E-20
UVM	TF	DDX1	ZNF432	0.814800728	3.74E-20
UVM	TF	DDX1	ZNF484	0.81481721	3.73E-20
UVM	TF	DDX1	ZNF45	0.815284081	3.41E-20
UVM	TF	DDX1	ZNF800	0.815974254	2.99E-20
UVM	TF	DDX1	MEF2A	0.816848918	2.53E-20
UVM	TF	DDX1	ZNF207	0.817734716	2.13E-20
UVM	TF	DDX1	ZNF701	0.818933799	1.69E-20
UVM	TF	DDX1	ZBTB33	0.819057652	1.65E-20
UVM	TF	DDX1	ZNF430	0.821839284	9.52E-21
UVM	TF	DDX1	ZNF143	0.822054226	9.12E-21
UVM	TF	DDX1	NR2C1	0.822613333	8.16E-21
UVM	TF	DDX1	ZNF780A	0.822658073	8.09E-21
UVM	TF	DDX1	ADNP2	0.822842049	7.80E-21
UVM	TF	DDX1	SMAD5	0.82296312	7.61E-21
UVM	TF	DDX1	NFE2L2	0.82448176	5.61E-21
UVM	TF	DDX1	ZNF675	0.82461641	5.46E-21
UVM	TF	DDX1	ARID2	0.82476292	5.30E-21
UVM	TF	DDX1	ZNF397	0.825333843	4.72E-21
UVM	TF	DDX1	ZNF572	0.825435623	4.62E-21
UVM	TF	DDX1	TOPORS	0.825680908	4.40E-21
UVM	TF	DDX1	ELF1	0.825756168	4.33E-21
UVM	TF	DDX1	SMAD4	0.825816936	4.28E-21
UVM	TF	DDX1	ZNF146	0.826145159	4.00E-21
UVM	TF	DDX1	FOXN2	0.827154044	3.25E-21
UVM	TF	DDX1	ZNF383	0.827427774	3.08E-21
UVM	TF	DDX1	ZNF180	0.828330657	2.55E-21
UVM	TF	DDX1	AHCTF1	0.829382421	2.05E-21
UVM	TF	DDX1	CLOCK	0.830020519	1.80E-21
UVM	TF	DDX1	ZNF791	0.831260189	1.38E-21
UVM	TF	DDX1	RBAK	0.831396458	1.34E-21
UVM	TF	DDX1	ZNF546	0.832336477	1.10E-21
UVM	TF	DDX1	ZNF33A	0.834582787	6.81E-22
UVM	TF	DDX1	ZNF75D	0.835564372	5.51E-22
UVM	TF	DDX1	ZNF510	0.835974548	5.04E-22
UVM	TF	DDX1	GPBP1	0.836114565	4.89E-22
UVM	TF	DDX1	ZNF527	0.837028799	4.00E-22
UVM	TF	DDX1	ZNF181	0.838830617	2.69E-22
UVM	TF	DDX1	ZNF658	0.839133308	2.51E-22
UVM	TF	DDX1	ZNF420	0.840646808	1.79E-22
UVM	TF	DDX1	ZNF451	0.841134888	1.61E-22
UVM	TF	DDX1	ELF2	0.841405246	1.51E-22
UVM	TF	DDX1	ZNF28	0.84186671	1.36E-22
UVM	TF	DDX1	THAP5	0.842268325	1.24E-22
UVM	TF	DDX1	ZNF131	0.844296706	7.81E-23
UVM	TF	DDX1	ZNF140	0.845403929	6.05E-23
UVM	TF	DDX1	TCF12	0.847090495	4.08E-23
UVM	TF	DDX1	ZNF43	0.849396777	2.36E-23
UVM	TF	DDX1	CREB1	0.851065312	1.58E-23
UVM	TF	DDX1	TERF1	0.851750279	1.34E-23
UVM	TF	DDX1	SP3	0.857382343	3.31E-24
UVM	TF	DDX1	YY1	0.857462679	3.24E-24
UVM	TF	DDX1	PURB	0.857803327	2.97E-24
UVM	TF	DDX1	ATF2	0.858535474	2.46E-24
UVM	TF	DDX1	PRDM10	0.862499292	8.80E-25
UVM	TF	DDX1	ZNF136	0.864224771	5.57E-25
UVM	TF	DDX1	IKZF5	0.868571867	1.70E-25
UVM	TF	DDX1	AEBP2	0.874346745	3.31E-26
UVM	TF	DDX1	ZBTB6	0.876386449	1.82E-26
UVM	TF	DDX1	ZBTB1	0.876646879	1.69E-26
UVM	TF	DDX1	PRMT3	0.88391236	1.82E-27
UVM	TF	DDX1	CEBPZ	0.899843704	7.86E-30
UVM	TSG	DDX1	RBBP8	0.801700895	4.12E-19
UVM	TSG	DDX1	DMTF1	0.804665989	2.43E-19
UVM	TSG	DDX1	CCAR1	0.80653619	1.74E-19
UVM	TSG	DDX1	NEDD4	0.808553529	1.20E-19
UVM	TSG	DDX1	HIF1A	0.808699982	1.17E-19
UVM	TSG	DDX1	PTPN12	0.812437561	5.85E-20
UVM	TSG	DDX1	APAF1	0.812932821	5.33E-20
UVM	TSG	DDX1	VEZT	0.812954737	5.31E-20
UVM	TSG	DDX1	PPP2R5C	0.813518451	4.77E-20
UVM	TSG	DDX1	EZH2	0.814114006	4.26E-20
UVM	TSG	DDX1	EGLN1	0.81763925	2.17E-20
UVM	TSG	DDX1	PTPN2	0.818566981	1.81E-20
UVM	TSG	DDX1	ANXA7	0.818732391	1.75E-20
UVM	TSG	DDX1	PAFAH1B1	0.821821101	9.56E-21
UVM	TSG	DDX1	WDR11	0.822570149	8.23E-21
UVM	TSG	DDX1	ARID2	0.82476292	5.30E-21
UVM	TSG	DDX1	TOPORS	0.825680908	4.40E-21
UVM	TSG	DDX1	SMAD4	0.825816936	4.28E-21
UVM	TSG	DDX1	FAM188A	0.826418284	3.78E-21
UVM	TSG	DDX1	GORAB	0.826480167	3.74E-21
UVM	TSG	DDX1	IFT88	0.827387593	3.10E-21
UVM	TSG	DDX1	BMPR2	0.828266605	2.59E-21
UVM	TSG	DDX1	PPM1A	0.830791773	1.53E-21
UVM	TSG	DDX1	CUL5	0.832205986	1.13E-21
UVM	TSG	DDX1	PRKAA1	0.833513473	8.57E-22
UVM	TSG	DDX1	MAP2K4	0.83533036	5.80E-22
UVM	TSG	DDX1	PDS5B	0.836051363	4.96E-22
UVM	TSG	DDX1	NAPEPLD	0.837094726	3.94E-22
UVM	TSG	DDX1	GTPBP4	0.843373496	9.66E-23
UVM	TSG	DDX1	KRIT1	0.843699027	8.97E-23
UVM	TSG	DDX1	DCLRE1A	0.847220916	3.95E-23
UVM	TSG	DDX1	SIRT1	0.851361583	1.47E-23
UVM	TSG	DDX1	CDC73	0.851548771	1.41E-23
UVM	TSG	DDX1	LIN9	0.853691617	8.32E-24
UVM	TSG	DDX1	BMPR1A	0.860740142	1.40E-24
UVM	TSG	DDX1	SUZ12	0.862266695	9.36E-25
UVM	TSG	DDX1	MLH3	0.868847843	1.58E-25
UVM	TSG	DDX1	INTS6	0.872090848	6.34E-26
UVM	TSG	DDX1	MSH2	0.879446913	7.28E-27
UVM	TSG	DDX1	CUL2	0.883285357	2.22E-27
UVM	TSG	DDX1	ATM	0.886430458	8.14E-28
UVM	TSG	DDX1	GGNBP2	0.889204982	3.28E-28
UVM	TSG	DDX1	SMCHD1	0.890509454	2.12E-28
UVM	TSG	DDX1	RINT1	0.895868953	3.32E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	DDX1	ZBTB8OS	1.09500645991288	0.000376403331756592
KICH	DDX1	TSEN2	2.28704821523232	0.000808119773864746
PRAD	DDX1	FAM98B	1.51991752527333	0.00155267706387314
KICH	DDX1	C2orf49	1.5633135532372	0.0027848482131958
CHOL	DDX1	C2orf49	-2.23908249418796	0.00390625
THCA	DDX1	HNRNPK	-8.73422542563389	0.00797530353045887
ESCA	DDX1	TSEN54	-1.71685253185035	0.013671875
CHOL	DDX1	TSEN2	-1.92897134305016	0.02734375
UCEC	DDX1	HNRNPK	1.64532744504864	0.03125
KIRP	DDX1	TSEN2	-3.07535884278372	0.0341199110262096
BRCA	DDX1	C2orf49	-1.15540611132205	0.0413357896985729
BLCA	DDX1	TSEN2	1.87956186868033	0.0445594787597656
KIRC	DDX1	FAM98B	-1.94784840482909	1.05445960630784e-07
BRCA	DDX1	ZBTB8OS	-2.38558199095104	1.5232755696552e-10
LIHC	DDX1	TSEN2	-1.05080312531688	2.16224521636684e-05
KIRC	DDX1	TSEN2	1.363854974391	2.47047805243583e-11
BRCA	DDX1	TSEN54	-2.41918898038537	2.62119186103299e-18
COAD	DDX1	TSEN54	2.44695448702288	3.27825546264649e-06
THCA	DDX1	TSEN54	-1.46188531789414	3.51403508280065e-06
LUAD	DDX1	C14orf166	-3.96429964299322	3.8171822568541e-09
LUSC	DDX1	FAM98A	-8.42067962479954	8.03131069907519e-10
HNSC	DDX1	TSEN2	1.11768597030137	8.08119216344495e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DDX1

CSTF2, HNRNPK, ATM, MRE11A, RAD50, NBN, SRRM2, MYC, Mapk13, HDAC5, PSMA3, NDRG1, HDGF, ARRB2, HNRNPA1, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, APP, RTCB, HNRNPM, PPP1CA, EEF1A1, C14orf166, FAM98B, RNF168, RANBP9, GEMIN5, STRN, TMED9, HMCN1, PLOD3, C2orf49, SCARB2, XPO1, FGFR1OP2, SAP30BP, EIF2S1, MCCC1, RPA2, UBE2I, ALDH18A1, TPR, VASP, HEXIM1, KATNAL2, STRIP1, POP1, HAS1, HNRNPD, PLOD1, LSM14A, RBM4, RC3H1, RHOA, NUP133, HSPA1A, FN1, VCAM1, ITGA4, CTNNB1, HDAC6, NME7, YWHAQ, SH3RF2, ABCF1, NELFB, YBX3, DHX9, DYNC1H1, DYNC1I2, EDC4, EIF2B2, EIF2B3, FKBP3, FLII, LRRFIP1, EIF3K, HNRNPA2B1, HNRNPU, IGF2BP3, ILF2, KRT18, NMT1, PDCD6, POLR1C, QARS, RFC2, RFC4, RPL26L1, RPL27, YBX1, rev, RPA3, RPA1, WWOX, ZBTB1, Fbxl16, STAU1, HUWE1, FUS, CUL7, OBSL1, LUZP4, ESR1, RPS6KB2, MAEL, KIAA0368, PPP1R8, SHMT2, EIF4EBP1, FAM98A, PICALM, RAVER1, THUMPD1, TSTA3, NTRK1, SCARNA22, HNRNPH2, NPM1, RPL10, Eif3a, Rpl35, Myh10, Rrbp1, Fus, MCM2, SNW1, UXS1, ANKS6, RFX3, HDAC1, XYLT2, DLD, SDHA, TRIM25, G3BP1, BRCA1, CLEC14A, PCBP1, PPP6C, TMPO, HSPA8, DIMT1, TGFB1, TRIP4, YAF2, YAP1, EFTUD2, PIH1D1, TNIP2, CHD3, CHD4, ARIH1, RIOK1, RUNX1, DPF2, PPT1, HERC2, AGR2, RECQL4, CSNK1A1, WDR76, HIST1H4A, HIST1H2BB, HIST1H2AB, GRWD1, METTL14, KIAA1429, EIF4B, RC3H2, ATG16L1, ACTC1, PHB, RIF1, DISC1, NR2C2, UBQLN2, ZBTB10, HDAC2, ZFYVE21, KRAS, BMH2, BMH1, COMMD3, SNRNP70, Dppa3, ITFG1, BIRC3, LMBR1L, NFX1, WWP2, BRD7, TP53, MATR3, ERCC6, SOX2, UCP3, nsp14ab, PLEKHA4, RAD18, PRMT8, PTEN, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ZFP64, DBT, PLA2G4A, ATXN2, CPEB4, DAZL, FAM98C, FBXO42, LMAN1, C2orf44, DDX3X, FUBP3, FXR2, IGF2BP1, IGF2BP2, LARP4B, LSM12, MEX3B, NUFIP2, PUM1, R3HDM2, RBMS1, TDRD3, UBAP2L, USP10, YTHDF3, FXR1, CIT, AURKB, KIF14, KIF20A, KIF23, PRC1, SUMO2, NDN, NUPR1, CIC, BRD4, Apc2, GLI1, RBM39, FBP1, LGALS9, IFI16, EIF3F, CUL4A, RNF4, RIN3, KDF1, SPOP, ISG15, UFL1, DDRGK1, FGA, FGG, FGB, USP11, BTF3, EP300, FBXW7, EIF4ENIF1, Rbm14, E, M, ORF10, RCHY1, KLF4, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DDX1	chr2	15760466	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DDX1	chr2	15769797	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DDX1	UCEC	chr2	15760365	15760365	G	A	Missense_Mutation	p.D414N	4
DDX1	BLCA	chr2	15758387	15758387	G	C	Missense_Mutation	p.R400T	4
DDX1	COAD	chr2	15768947	15768947	C	T	Missense_Mutation	p.A620V	3
DDX1	COAD	chr2	15747341	15747341	C	T	Missense_Mutation	p.P287L	3
DDX1	LIHC	chr2	15768807	15768807	G	A	Missense_Mutation	p.R602Q	3
DDX1	UCEC	chr2	15744594	15744594	C	T	Silent	p.L196	2
DDX1	SKCM	chr2	15769734	15769734	C	T	Silent	p.Y628Y	2
DDX1	STAD	chr2	15760382	15760382	C	T	Silent	p.S419S	2
DDX1	CESC	chr2	15732065	15732065	C	T	Missense_Mutation		2
DDX1	UCEC	chr2	15746297	15746297	C	T	Silent	p.F242	2
DDX1	LIHC	chr2	15736869	15736869	A	T	Silent	p.T48T	2
DDX1	SKCM	chr2	15735288	15735288	G	A	Silent	p.E12E	2
DDX1	STAD	chr2	15769774	15769774	A	G	Missense_Mutation	p.R642G	2
DDX1	UCEC	chr2	15736871	15736871	G	A	Missense_Mutation	p.G49E	2
DDX1	SKCM	chr2	15768938	15768938	C	T	Missense_Mutation	p.S617F	2
DDX1	STAD	chr2	15760451	15760451	C	A	Missense_Mutation	p.H442Q	2
DDX1	UCEC	chr2	15743376	15743376	C	T	Missense_Mutation	p.T151I	2
DDX1	UCEC	chr2	15760382	15760382	C	T	Silent	p.S419	2
DDX1	LUAD	chr2	15747309	15747309	G	C	Missense_Mutation	p.Q276H	2
DDX1	CESC	chr2	15769775	15769775	G	A	Missense_Mutation		2
DDX1	KIRP	chr2	15735617	15735617	C	T	Silent	p.L24L	2
DDX1	STAD	chr2	15746096	15746096	T	C	Silent	p.F216F	2
DDX1	SARC	chr2	15769733	15769733	A	C	Missense_Mutation		2
DDX1	UCEC	chr2	15769729	15769729	T	C	Missense_Mutation	p.W627R	2
DDX1	LUAD	chr2	15760365	15760365	G	T	Missense_Mutation	p.D414Y	2
DDX1	LAML	chr2	15674817	15674817	A	G	Splice_Site	e15-2	2
DDX1	STAD	chr2	15742747	15742747	T	C	Missense_Mutation	p.L128S	2
DDX1	LUAD	chr2	15760486	15760486	G	T	Missense_Mutation	p.R454I	2
DDX1	STAD	chr2	15769793	15769793	G	T	Missense_Mutation	p.G648V	2
DDX1	LIHC	chr2	15763608	15763608	G	-	Frame_Shift_Del	p.R499fs	2
DDX1	ESCA	chr2	15746352	15746352	G	A	Missense_Mutation	p.A261T	2
DDX1	STAD	chr2	15747341	15747341	C	T	Missense_Mutation		2
DDX1	LIHC	chr2	15736869	15736869	A	T	Silent		2
DDX1	STAD	chr2	15771006	15771006	T	C	Silent	p.P733P	2
DDX1	SARC	chr2	15769733	15769733	A	C	Missense_Mutation	p.Y628S	2
DDX1	BLCA	chr2	15758387	15758387	G	C	Missense_Mutation		2
DDX1	ESCA	chr2	15735282	15735282	G	T	Missense_Mutation	p.M10I	2
DDX1	LUAD	chr2	15742716	15742716	G	T	Nonsense_Mutation	p.E118*	2
DDX1	STAD	chr2	15763564	15763564	G	A	Missense_Mutation		2
DDX1	BLCA	chr2	15753407	15753407	G	C	Splice_Site	p.G339A	2
DDX1	STAD	chr2	15743351	15743351	G	A	Missense_Mutation	p.G143R	2
DDX1	SKCM	chr2	15763627	15763627	G	A	Silent	p.K505K	2
DDX1	BLCA	chr2	15768964	15768964	G	A	Splice_Site		2
DDX1	STAD	chr2	15770213	15770213	G	A	Missense_Mutation		2
DDX1	HNSC	chr2	15768620	15768620	G	T	Missense_Mutation	p.D580Y	2
DDX1	STAD	chr2	15742674	15742674	A	G	Missense_Mutation	p.I104V	2
DDX1	LIHC	chr2	15743979	15743979	A	-	Frame_Shift_Del	p.K173fs	2
DDX1	SKCM	chr2	15770985	15770985	C	T	Silent	p.F726F	2
DDX1	STAD	chr2	15763564	15763564	G	A	Missense_Mutation	p.M484I	2
DDX1	HNSC	chr2	15758345	15758345	G	A	Missense_Mutation	p.R386K	2
DDX1	SKCM	chr2	15763586	15763586	C	T	Silent	p.L492L	2
DDX1	LUSC	chr2	15770167	15770167	G	T	Silent	p.P675P	2
DDX1	STAD	chr2	15770213	15770213	G	A	Missense_Mutation	p.G691S	2
DDX1	COAD	chr2	15760399	15760399	T	C	Missense_Mutation	p.F425S	1
DDX1	LIHC	chr2	15746378	15746378	A	G	Silent	p.S269S	1
DDX1	PRAD	chr2	15747405	15747405	G	A	Silent	p.Q308Q	1
DDX1	UCEC	chr2	15743391	15743391	T	C	Missense_Mutation	p.L156S	1
DDX1	LIHC	chr2	15763658	15763658	A	-	Frame_Shift_Del	p.K516fs	1
DDX1	BLCA	chr2	15742725	15742725	G	T	Missense_Mutation		1
DDX1	ESCA	chr2	15742751	15742751	G	T	Missense_Mutation	p.M129I	1
DDX1	LUSC	chr2	15746377	15746377	C	T	Missense_Mutation	p.S269L	1
DDX1	HNSC	chr2	15760415	15760416	-	T	Frame_Shift_Ins	p.K431fs	1
DDX1	COAD	chr2	15768639	15768639	A	G	Missense_Mutation	p.Y586C	1
DDX1	PRAD	chr2	15770187	15770187	A	G	Missense_Mutation	p.D682G	1
DDX1	UCEC	chr2	15743363	15743363	G	T	Missense_Mutation	p.V147F	1
DDX1	LUAD	chr2	15770224	15770224	G	T	Missense_Mutation	p.R694S	1
DDX1	BLCA	chr2	15761231	15761231	A	G	Missense_Mutation		1
DDX1	ESCA	chr2	15757366	15757366	A	G	Splice_Site	.	1
DDX1	LUSC	chr2	15757435	15757435	C	G	Missense_Mutation	p.S362C	1
DDX1	CESC	chr2	15743351	15743351	G	T	Missense_Mutation		1
DDX1	HNSC	chr2	15770222	15770222	A	G	Missense_Mutation	p.R694G	1
DDX1	PRAD	chr2	15753347	15753347	G	T	Splice_Site		1
DDX1	LUAD	chr2	15735280	15735280	A	T	Missense_Mutation	p.M10L	1
DDX1	BLCA	chr2	15763704	15763704	G	T	Missense_Mutation		1
DDX1	ESCA	chr2	15768942	15768942	G	T	Silent		1
DDX1	CESC	chr2	15769813	15769813	G	A	Missense_Mutation		1
DDX1	KIRC	chr2	15758358	15758358	G	C	Missense_Mutation	p.Q390H	1
DDX1	LUSC	chr2	15760450	15760450	A	T	Missense_Mutation	p.H442L	1
DDX1	READ	chr2	15742743	15742743	G	T	Nonsense_Mutation	p.G127X	1
DDX1	COAD	chr2	15769812	15769812	C	T	Silent	p.N654N	1
DDX1	SKCM	chr2	15769735	15769735	C	G	Missense_Mutation	p.H629D	1
DDX1	BLCA	chr2	15744000	15744000	G	C	Missense_Mutation	p.D180H	1
DDX1	GBM	chr2	15770154	15770154	C	T	Missense_Mutation		1
DDX1	LUSC	chr2	15760423	15760423	G	T	Missense_Mutation	p.G433V	1
DDX1	BLCA	chr2	15744000	15744000	G	C	Missense_Mutation		1
DDX1	SKCM	chr2	15739817	15739817	C	T	Missense_Mutation	p.P95L	1
DDX1	BLCA	chr2	15746099	15746099	A	C	Missense_Mutation	p.E217D	1
DDX1	HNSC	chr2	15768620	15768620	G	T	Missense_Mutation		1
DDX1	CESC	chr2	15743960	15743960	C	C	Silent		1
DDX1	LUSC	chr2	15770902	15770902	G	T	Nonsense_Mutation	p.G699*	1
DDX1	SARC	chr2	15753387	15753387	G	T	Missense_Mutation		1
DDX1	BLCA	chr2	15746099	15746099	A	C	Missense_Mutation		1
DDX1	COAD	chr2	15763662	15763662	T	A	Missense_Mutation	p.I517N	1
DDX1	SKCM	chr2	15761225	15761225	G	A	Missense_Mutation	p.G478S	1
DDX1	BLCA	chr2	15746297	15746297	C	T	Silent	p.F242F	1
DDX1	HNSC	chr2	15758345	15758345	G	A	Missense_Mutation		1
DDX1	CESC	chr2	15743960	15743960	C	T	Silent	p.G166	1
DDX1	LIHC	chr2	15739830	15739830	A	G	Silent		1
DDX1	LUSC	chr2	15767206	15767206	A	T	Silent	p.S541S	1
DDX1	SARC	chr2	15743959	15743959	G	T	Missense_Mutation		1
DDX1	BLCA	chr2	15746297	15746297	C	T	Silent		1
DDX1	LUAD	chr2	15768800	15768800	G	A	Missense_Mutation	p.V600I	1
DDX1	HNSC	chr2	15737538	15737538	C	T	Silent		1
DDX1	CESC	chr2	15769775	15769775	G	A	Missense_Mutation	p.R642K	1
DDX1	MESO	chr2	15770926	15770926	A	G	Missense_Mutation		1
DDX1	LIHC	chr2	15746115	15746115	A	-	Frame_Shift_Del	p.K223fs	1
DDX1	HNSC	chr2	15760415	15760416	-	-	Frame_Shift_Ins		1
DDX1	COAD	chr2	15735648	15735648	T	C	Silent	p.L35L	1
DDX1	MESO	chr2	15770926	15770926	A	G	Missense_Mutation	p.I707V	1
DDX1	LIHC	chr2	15758382	15758382	A	-	Frame_Shift_Del	p.G398fs	1
DDX1	ESCA	chr2	15757366	15757366	A	G	Splice_Site	e15-2	1
DDX1	LUAD	chr2	15767219	15767219	C	G	Missense_Mutation	p.H546D	1
DDX1	BLCA	chr2	15742725	15742725	G	T	Missense_Mutation	p.G121W	1
DDX1	COAD	chr2	15753352	15753352	C	A	Missense_Mutation	p.L321I	1
DDX1	LIHC	chr2	15758310	15758310	G	T	Silent	p.G374G	1
DDX1	OV	chr2	15760383	15760383	G	A	Missense_Mutation	p.E420K	1
DDX1	BLCA	chr2	15753407	15753407	G	C	Missense_Mutation		1
DDX1	ESCA	chr2	15768942	15768942	G	T	Silent	p.L618	1
DDX1	LUSC	chr2	15770898	15770898	A	T	Splice_Site	p.G698_splice	1
DDX1	BLCA	chr2	15761231	15761231	A	G	Missense_Mutation	p.N480D	1
DDX1	COAD	chr2	15753362	15753362	T	C	Missense_Mutation	p.I324T	1
DDX1	LIHC	chr2	15737583	15737583	A	C	Missense_Mutation	p.T83P	1
DDX1	OV	chr2	15670831	15670831	G	A	Missense_Mutation	p.R330Q	1
DDX1	THYM	chr2	15757383	15757383	G	T	Missense_Mutation	p.G345C	1
DDX1	LIHC	chr2	15743991	15743991	A	-	Frame_Shift_Del	p.K177fs	1
DDX1	BLCA	chr2	15747367	15747367	C	A	Silent		1
DDX1	ESCA	chr2	15746352	15746352	G	A	Missense_Mutation		1
DDX1	BLCA	chr2	15763704	15763704	G	T	Missense_Mutation	p.G531V	1
DDX1	HNSC	chr2	15737538	15737538	C	T	Silent	p.L68L	1

Copy number variation (CNV) of DDX1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DDX1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97715	N/A	FN071721	DDX1	chr2	15746139	-	ANKS1B	chr12	99975349	+
95130	HNSC	TCGA-CV-5441-01A	DDX1	chr2	15736887	+	C3orf67	chr3	58792182	-
103062	N/A	BG473709	DDX1	chr2	15760492	-	RPL28	chr19	55897300	+
75239	N/A	BG329765	GABRB3	chr15	26790498	-	DDX1	chr2	15768763	+
75239	BLCA	TCGA-G2-A2EF	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+
75239	BLCA	TCGA-G2-A2EF-01A	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+
75239	LUSC	TCGA-85-6561	NBAS	chr2	15467874	-	DDX1	chr2	15735269	+
75240	N/A	DA765942	RNU6ATAC	chr9	137029560	-	DDX1	chr2	15731992	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	DDX1	0.000106128967515574	0.003
LUAD	DDX1	0.0154122065654287	0.42
LIHC	DDX1	0.0307187525091819	0.8
HNSC	DDX1	0.046479469039311	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KICH	DDX1	0.00910393224322005	0.3

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0014173	Endometrial Hyperplasia	1	CTD_human
C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
C0038580	Substance Dependence	1	CTD_human
C0349578	Complex Endometrial Hyperplasia	1	CTD_human
C0349579	Atypical Endometrial Hyperplasia	1	CTD_human
C0456483	Simple Endometrial Hyperplasia	1	CTD_human
C0740858	Substance abuse problem	1	CTD_human