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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DRD3 (NCBI Gene ID:1814)

Gene Summary

Gene Summary

Gene Information	Gene Name: DRD3
	Gene ID: 1814
	Gene Symbol	DRD3
	Gene ID	1814
	Gene Name	dopamine receptor D3
	Synonyms	D3DR\|ETM1\|FET1
	Cytomap	3q13.31
	Type of Gene	protein-coding
	Description	D(3) dopamine receptoressential tremor 1
	Modification date	20200315
	UniProtAcc	P35462

Child GO biological process term(s) under GO:0006412

GO ID

GO term

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DRD3	GO:0002031	G protein-coupled receptor internalization	18424554
Hgene	DRD3	GO:0006874	cellular calcium ion homeostasis	7911712
Hgene	DRD3	GO:0007186	G protein-coupled receptor signaling pathway	7911712
Hgene	DRD3	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	18424554
Hgene	DRD3	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	7907363\|8666994\|18424554
Hgene	DRD3	GO:0034776	response to histamine	16839358
Hgene	DRD3	GO:0050482	arachidonic acid secretion	8301582
Hgene	DRD3	GO:0050709	negative regulation of protein secretion	16839358

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'DRD3[title] AND translation [title] AND human.'

Gene	Title	PMID
DRD3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DRD3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
HNSC	DRD3	DRD4	-4.21480834070718	0.000102781329587742
HNSC	DRD3	GNAI2	-1.63788962305884	0.000412285219226761
KIRC	DRD3	COMT	1.47836258495866	0.000487253612480757
BLCA	DRD3	GNAI1	-2.93520499171855	0.000644683837890625
COAD	DRD3	BDNF	-1.55628441861795	0.000934779644012452
PRAD	DRD3	SLC6A4	1.16206063465462	0.00109529931302818
PRAD	DRD3	GNAI1	1.58271996200084	0.00116785923777763
LUSC	DRD3	ANKK1	1.86618585979595	0.00339826502432084
KIRP	DRD3	GNB2	-3.92698486191909	0.00434928730814166
LUSC	DRD3	GNAI1	1.19035009670475	0.00499504210390278
LUSC	DRD3	SLC6A3	-3.12170449437341	0.0059393237503163
CHOL	DRD3	GNB3	-2.28465398261697	0.0078125
LUAD	DRD3	GNAI1	-2.83612098688685	0.00887287917335037
CHOL	DRD3	BDNF	-2.56741936038475	0.01171875
CHOL	DRD3	COMT	-1.07372064465474	0.01171875
CHOL	DRD3	SLC6A4	-1.22279970172259	0.0142661867014469
KIRP	DRD3	GNAI2	-1.76317885674256	0.0148032568395138
LUAD	DRD3	SLC6A3	1.35821040201445	0.0182052890234661
CHOL	DRD3	SLC6A3	-3.71301830948578	0.02734375
KICH	DRD3	BDNF	1.89726744357368	0.0274794101715088
READ	DRD3	COMT	-4.28506130394875	0.03125
BRCA	DRD3	SLC6A4	1.91263158501749	0.036144165937263
KIRP	DRD3	ANKK1	-9.01110053426812	0.0413399673998356
LIHC	DRD3	COMT	-2.73019242658692	1.10045092764477e-07
KIRC	DRD3	GNAI1	-1.31329528573479	1.28330819964462e-11
LUSC	DRD3	BDNF	-1.68272429718227	1.28930383462867e-06
PRAD	DRD3	BDNF	-2.83810529416596	1.37654470439417e-07
THCA	DRD3	SLC6A3	-4.06801636862211	1.52069486270417e-09
LUSC	DRD3	DRD4	-2.41872030088879	1.55603189752189e-06
KICH	DRD3	GNAI2	1.5581282885874	1.78813934326172e-07
THCA	DRD3	GNB2	-3.16043246794419	2.00093786358815e-08
KIRC	DRD3	DRD4	-1.07844174851302	2.18353613355818e-05
BRCA	DRD3	BDNF	3.24591816106231	2.9402332585108e-19
KIRC	DRD3	ANKK1	-1.27807099205207	2.98666385548396e-06
BRCA	DRD3	GNB2	-1.32338673482875	3.2327270843168e-12
PRAD	DRD3	GNB2	1.62834239040446	3.31798643818129e-07
LUAD	DRD3	SLC6A4	-5.00880087910183	3.59910232594763e-11
KIRC	DRD3	SLC6A3	3.07827681348267	5.00897740892013e-13
LUSC	DRD3	SLC6A4	-2.87713272681495	5.97174133915752e-10
HNSC	DRD3	GNAI1	1.4612266170729	6.04393335379428e-08
LUAD	DRD3	GNAI2	-2.88441995649892	6.38046146019279e-11
THCA	DRD3	COMT	-1.00078453085988	6.42442896273628e-05
LUAD	DRD3	GNB3	-2.57353461384531	6.67503596157052e-07
BRCA	DRD3	DRD4	-1.95106829703492	6.71547051892467e-10
KICH	DRD3	ANKK1	1.41252754516219	8.80360603332519e-05
KICH	DRD3	GNB3	1.47109026605172	8.80360603332519e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DRD3

FLNA, CLIC6, MPDZ, GIPC1, RDX, NCS1, EPB41L1, GRB2, SLC9A3, USP48, PRKCB, DRD1, PDCD6IP, GNAO1, MDM2, RGS9, HIST1H1B, DUSP14, PTDSS2, MRS2, LRRC15, DSG4, SELENBP1, HIST2H3PS2, BRI3BP, TM9SF4, VSIG8, CSNK1D,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DRD3	chr3	113847615	G	T	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD3	chr3	113847689	G	A	single_nucleotide_variant	Benign/Likely_benign	Hereditary_essential_tremor_1\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD3	chr3	113847719	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD3	chr3	113849984	T	C	single_nucleotide_variant	Benign	Hereditary_essential_tremor_1\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD3	chr3	113850017	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
DRD3	chr3	113850050	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
DRD3	chr3	113850150	C	T	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD3	chr3	113858350	C	.	Variation	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0002073\|no_sequence_alteration	SO:0001819\|synonymous_variant,SO:0002073\|no_sequence_alteration
DRD3	chr3	113858350	C	T	single_nucleotide_variant	Benign	Hereditary_essential_tremor_1	SO:0001819\|synonymous_variant,SO:0002073\|no_sequence_alteration	SO:0001819\|synonymous_variant,SO:0002073\|no_sequence_alteration
DRD3	chr3	113858379	A	T	single_nucleotide_variant	Likely_benign	Hereditary_essential_tremor_1	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD3	chr3	113866382	C	T	single_nucleotide_variant	Likely_benign	Hereditary_essential_tremor_1	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD3	chr3	113866383	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD3	chr3	113876275	G	A	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD3	chr3	113878595	G	A	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD3	chr3	113878661	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD3	chr3	113878683	A	C	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD3	chr3	113890556	T	C	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD3	chr3	113890711	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD3	chr3	113890728	C	T	single_nucleotide_variant	Likely_benign	Hereditary_essential_tremor_1	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD3	chr3	113890789	T	C	single_nucleotide_variant	Benign	Hereditary_essential_tremor_1	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD3	chr3	113890815	C	.	single_nucleotide_variant	Benign	not_specified	SO:0002073\|no_sequence_alteration	SO:0002073\|no_sequence_alteration
DRD3	chr3	113890815	C	T	single_nucleotide_variant	Benign/Likely_benign	Essential_tremor,_susceptibility_to\|Schizophrenia,_susceptibility_to\|Hereditary_essential_tremor_1\|not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD3	chr3	113897506	T	G	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
DRD3	chr3	113897573	C	T	single_nucleotide_variant	Likely_benign	Hereditary_essential_tremor_1	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
DRD3	chr3	113897582	T	C	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
DRD3	chr3	113897621	A	C	single_nucleotide_variant	Likely_benign	Hereditary_essential_tremor_1	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
DRD3	chr3	113897720	G	A	single_nucleotide_variant	Likely_benign	Hereditary_essential_tremor_1	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
DRD3	chr3	113897749	T	C	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
DRD3	chr3	113897754	T	G	single_nucleotide_variant	Likely_benign	Hereditary_essential_tremor_1	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
DRD3	chr3	113897786	G	A	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
DRD3	chr3	113897801	C	T	single_nucleotide_variant	Benign	Hereditary_essential_tremor_1	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
DRD3	chr3	113897856	A	T	single_nucleotide_variant	Uncertain_significance	Hereditary_essential_tremor	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DRD3	LUAD	chr3	113890711	113890711	G	A	Silent	p.I43I	5
DRD3	LIHC	chr3	113850028	113850028	G	-	Frame_Shift_Del	p.L315fs	5
DRD3	LUAD	chr3	113890706	113890706	A	T	Missense_Mutation	p.F45Y	5
DRD3	LUAD	chr3	113866313	113866313	C	A	Missense_Mutation	p.V159L	5
DRD3	BLCA	chr3	113850098	113850098	C	T	Silent	p.A291A	5
DRD3	HNSC	chr3	113858410	113858410	C	T	Silent	p.R220R	5
DRD3	CESC	chr3	113850099	113850099	G	A	Missense_Mutation	p.A291V	4
DRD3	HNSC	chr3	113858352	113858352	G	T	Missense_Mutation		4
DRD3	BRCA	chr3	113890710	113890710	C	T	Missense_Mutation	p.V44I	3
DRD3	ESCA	chr3	113850244	113850244	G	A	Missense_Mutation	p.L243F	3
DRD3	ESCA	chr3	113878649	113878649	C	T	Missense_Mutation	p.M112I	3
DRD3	LUAD	chr3	113858370	113858370	C	A	Missense_Mutation	p.V234F	3
DRD3	LIHC	chr3	113858350	113858350	C	-	Frame_Shift_Del	p.Q241fs	3
DRD3	HNSC	chr3	113866346	113866346	G	A	Missense_Mutation	p.R148W	3
DRD3	UCS	chr3	113850128	113850128	C	G	Missense_Mutation	p.K281N	3
DRD3	LUAD	chr3	113849986	113849986	G	-	Frame_Shift_Del	p.Q329fs	3
DRD3	PRAD	chr3	113850057	113850057	C	G	Missense_Mutation	p.R305T	3
DRD3	BLCA	chr3	113847578	113847578	C	G	Missense_Mutation	p.K396N	3
DRD3	HNSC	chr3	113858410	113858410	C	T	Silent		3
DRD3	SARC	chr3	113866275	113866275	G	T	Silent		2
DRD3	UCEC	chr3	113850240	113850240	G	T	Missense_Mutation	p.S244Y	2
DRD3	LUAD	chr3	113890705	113890705	G	A	Silent	p.F45F	2
DRD3	SKCM	chr3	113890585	113890585	C	G	Missense_Mutation	p.W85C	2
DRD3	CESC	chr3	113850099	113850099	G	A	Missense_Mutation		2
DRD3	KIRC	chr3	113858392	113858392	T	A	Silent	p.R226R	2
DRD3	SARC	chr3	113850079	113850079	C	A	Missense_Mutation		2
DRD3	UCEC	chr3	113858394	113858394	G	A	Nonsense_Mutation	p.R226*	2
DRD3	HNSC	chr3	113858352	113858352	G	T	Missense_Mutation	p.Q240K	2
DRD3	SKCM	chr3	113890723	113890723	G	A	Silent	p.L39L	2
DRD3	CESC	chr3	113850143	113850143	C	G	Missense_Mutation		2
DRD3	SARC	chr3	113850156	113850156	C	A	Missense_Mutation		2
DRD3	UCEC	chr3	113858457	113858457	C	-	Frame_Shift_Del	p.V205fs	2
DRD3	CESC	chr3	113866346	113866346	G	T	Silent		2
DRD3	ESCA	chr3	113878649	113878649	C	T	Missense_Mutation		2
DRD3	LUAD	chr3	113866281	113866281	C	G	Silent	p.L169L	2
DRD3	SARC	chr3	113850156	113850156	C	A	Missense_Mutation	p.R272I	2
DRD3	UCEC	chr3	113858530	113858530	G	T	Silent	p.V180	2
DRD3	BLCA	chr3	113850098	113850098	C	T	Silent		2
DRD3	STAD	chr3	113850002	113850002	C	T	Silent	p.R323R	2
DRD3	LIHC	chr3	113890588	113890588	G	-	Frame_Shift_Del	p.P84fs	2
DRD3	SARC	chr3	113850079	113850079	C	A	Missense_Mutation	p.V298F	2
DRD3	UCEC	chr3	113878617	113878617	G	A	Missense_Mutation	p.A123V	2
DRD3	HNSC	chr3	113850024	113850024	T	G	Missense_Mutation	p.Q316P	2
DRD3	STAD	chr3	113878640	113878640	T	C	Silent	p.T115T	2
DRD3	SKCM	chr3	113878668	113878668	A	C	Missense_Mutation	p.F106C	2
DRD3	STAD	chr3	113890743	113890743	C	T	Missense_Mutation	p.A33T	2
DRD3	LUAD	chr3	113890579	113890579	T	A	Silent	p.V87V	2
DRD3	SKCM	chr3	113890624	113890624	A	G	Silent	p.A72A	2
DRD3	HNSC	chr3	113850003	113850003	C	A	Missense_Mutation	p.R323L	2
DRD3	STAD	chr3	113850211	113850211	G	A	Missense_Mutation	p.R254C	2
DRD3	SKCM	chr3	113850136	113850136	C	T	Missense_Mutation	p.E279K	2
DRD3	UCEC	chr3	113847724	113847724	T	C	Missense_Mutation	p.T348A	2
DRD3	COAD	chr3	113850076	113850076	G	A	Nonsense_Mutation	p.R299X	2
DRD3	LIHC	chr3	113850192	113850192	T	G	Missense_Mutation		2
DRD3	LUAD	chr3	113890615	113890615	G	T	Missense_Mutation	p.D75E	2
DRD3	LUAD	chr3	113850108	113850108	G	T	Missense_Mutation	p.P288H	2
DRD3	SKCM	chr3	113858383	113858383	A	C	Missense_Mutation	p.S229R	2
DRD3	BLCA	chr3	113847752	113847752	G	A	Silent	p.F338F	2
DRD3	UCEC	chr3	113847743	113847743	G	A	Silent	p.C341	2
DRD3	COAD	chr3	113858437	113858437	G	T	Silent	p.I211I	2
DRD3	LUAD	chr3	113850152	113850152	T	A	Silent	p.G273G	2
DRD3	SKCM	chr3	113850117	113850117	G	A	Missense_Mutation	p.S285F	2
DRD3	KICH	chr3	113890761	113890761	G	A	Missense_Mutation	p.R27C	2
DRD3	UCEC	chr3	113850124	113850124	G	A	Missense_Mutation	p.R283W	2
DRD3	LIHC	chr3	113850192	113850192	T	G	Missense_Mutation	p.Q260P	2
DRD3	LUAD	chr3	113850231	113850231	G	A	Missense_Mutation	p.P247L	2
DRD3	SKCM	chr3	113878691	113878691	G	A	Silent	p.F98F	2
DRD3	STAD	chr3	113849976	113849976	G	A	Missense_Mutation	p.A332V	1
DRD3	KIRC	chr3	113858457	113858457	C	G	Missense_Mutation	p.V205L	1
DRD3	LUSC	chr3	113847632	113847632	G	A	Silent	p.L378L	1
DRD3	SKCM	chr3	113878698	113878698	C	T	Nonsense_Mutation	p.W96*	1
DRD3	COAD	chr3	113878641	113878641	G	A	Missense_Mutation	p.T115I	1
DRD3	LIHC	chr3	113890665	113890665	C	A	Missense_Mutation	p.A59S	1
DRD3	HNSC	chr3	113850160	113850160	C	T	Missense_Mutation		1
DRD3	STAD	chr3	113847734	113847734	G	A	Silent	p.P344P	1
DRD3	LUSC	chr3	113878657	113878657	C	T	Missense_Mutation	p.D110N	1
DRD3	SKCM	chr3	113850029	113850029	G	A	Silent	p.P314P	1
DRD3	LIHC	chr3	113858512	113858513	-	G	Frame_Shift_Ins	p.R186fs	1
DRD3	LUAD	chr3	113850168	113850168	C	A	Missense_Mutation	p.G268V	1
DRD3	STAD	chr3	113866314	113866314	C	T	Nonsense_Mutation	p.W158*	1
DRD3	LGG	chr3	113878660	113878660	G	A	Silent	p.L109L	1
DRD3	LUSC	chr3	113858465	113858465	C	A	Missense_Mutation	p.G202V	1
DRD3	SKCM	chr3	113847728	113847728	G	A	Silent	p.F346F	1
DRD3	ACC	chr3	113890760	113890760	C	A	Missense_Mutation	p.R27L	1
DRD3	HNSC	chr3	113878602	113878602	C	T	Splice_Site	p.R128_splice	1
DRD3	LUAD	chr3	113850171	113850171	G	T	Missense_Mutation	p.P267Q	1
DRD3	SKCM	chr3	113858352	113858352	G	A	Nonsense_Mutation	p.Q240*	1
DRD3	STAD	chr3	113847607	113847607	T	C	Missense_Mutation	p.N387D	1
DRD3	LGG	chr3	113847660	113847660	G	A	Missense_Mutation	p.T369I	1
DRD3	LUSC	chr3	113849981	113849981	C	T	Missense_Mutation	p.M330I	1
DRD3	STAD	chr3	113850002	113850002	C	T	Silent		1
DRD3	HNSC	chr3	113850160	113850160	C	T	Missense_Mutation	p.E271K	1
DRD3	LUAD	chr3	113866357	113866357	T	A	Missense_Mutation	p.Q144L	1
DRD3	SKCM	chr3	113890786	113890786	C	T	Silent	p.E18E	1
DRD3	STAD	chr3	113890604	113890604	G	A	Missense_Mutation	p.A79V	1
DRD3	LGG	chr3	113890729	113890729	G	A	Silent	p.C37C	1
DRD3	LUSC	chr3	113850162	113850162	T	C	Missense_Mutation	p.Q270R	1
DRD3	ESCA	chr3	113850244	113850244	G	A	Missense_Mutation		1
DRD3	LUAD	chr3	113858349	113858349	G	T	Missense_Mutation	p.Q241K	1
DRD3	BLCA	chr3	113847752	113847752	G	A	Silent		1
DRD3	LUAD	chr3	113866356	113866356	C	A	Missense_Mutation	p.Q144H	1
DRD3	SKCM	chr3	113847575	113847575	G	A	Silent	p.I397I	1
DRD3	STAD	chr3	113890790	113890790	G	A	Missense_Mutation	p.A17V	1
DRD3	CESC	chr3	113850143	113850143	C	G	Missense_Mutation	p.L276F	1
DRD3	LGG	chr3	113866319	113866319	C	T	Missense_Mutation	p.V157I	1
DRD3	OV	chr3	113890742	113890742	G	T	Missense_Mutation	p.A33D	1
DRD3	GBM	chr3	113847759	113847759	C	T	Missense_Mutation	p.G336_splice	1
DRD3	LIHC	chr3	113890673	113890673	T	-	Frame_Shift_Del	p.K56fs	1
DRD3	LUAD	chr3	113890669	113890669	C	A	Missense_Mutation	p.E57D	1
DRD3	UCS	chr3	113850128	113850128	C	G	Missense_Mutation		1
DRD3	BLCA	chr3	113847578	113847578	C	G	Missense_Mutation		1
DRD3	LUAD	chr3	113850215	113850215	C	A	Silent	p.L252L	1
DRD3	SKCM	chr3	113850015	113850015	C	T	Missense_Mutation	p.G319E	1
DRD3	PRAD	chr3	113890728	113890728	C	T	Missense_Mutation	p.A38T	1
DRD3	THYM	chr3	113858364	113858364	G	T	Missense_Mutation		1
DRD3	CESC	chr3	113866346	113866346	G	T	Silent	p.R148	1
DRD3	LGG	chr3	113847660	113847660	G	A	Missense_Mutation		1
DRD3	BLCA	chr3	113847575	113847575	G	A	Silent		1
DRD3	SKCM	chr3	113850238	113850238	G	A	Missense_Mutation	p.P245S	1
DRD3	UCEC	chr3	113866323	113866323	C	G	Silent	p.T155T	1
DRD3	COAD	chr3	113847662	113847662	C	T	Silent	p.T335T	1
DRD3	LIHC	chr3	113847668	113847668	A	G	Silent		1
DRD3	HNSC	chr3	113850003	113850003	C	A	Missense_Mutation		1
DRD3	LUAD	chr3	113850212	113850212	C	G	Missense_Mutation	p.K253N	1
DRD3	LUAD	chr3	113847755	113847755	G	-	Frame_Shift_Del	p.A337fs	1
DRD3	SKCM	chr3	113890765	113890765	C	T	Silent	p.Q25Q	1
DRD3	PRAD	chr3	113866343	113866344	-	C	Frame_Shift_Ins	p.R149fs	1
DRD3	STAD	chr3	113858530	113858530	G	T	Silent	p.V180V	1
DRD3	HNSC	chr3	113850024	113850024	T	G	Missense_Mutation		1
DRD3	KICH	chr3	113890761	113890761	G	A	Missense_Mutation		1
DRD3	LUSC	chr3	113890720	113890720	G	A	Silent	p.I40I	1
DRD3	SKCM	chr3	113850050	113850050	C	T	Silent	p.S307S	1
DRD3	READ	chr3	113858507	113858507	A	C	Missense_Mutation	p.F188C	1
DRD3	STAD	chr3	113866314	113866314	C	T	Nonsense_Mutation	p.W158X	1
DRD3	LIHC	chr3	113847610	113847610	A	G	Missense_Mutation		1
DRD3	HNSC	chr3	113878602	113878602	C	T	Missense_Mutation		1
DRD3	LUAD	chr3	113850048	113850048	G	A	Missense_Mutation	p.T308I	1
DRD3	LUSC	chr3	113890804	113890804	G	A	Silent	p.N12N	1
DRD3	SKCM	chr3	113858523	113858523	T	G	Missense_Mutation	p.I183L	1
DRD3	READ	chr3	113878601	113878601	C	T	Splice_Site	.	1
DRD3	COAD	chr3	113866363	113866363	G	A	Missense_Mutation	p.T142M	1
DRD3	LUAD	chr3	113849973	113849973	A	G	Missense_Mutation	p.I333T	1

Copy number variation (CNV) of DRD3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DRD3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
57029	LUAD	TCGA-35-5375-01A	LRBA	chr4	151749332	-	DRD3	chr3	113847759	-
57051	HNSC	TCGA-BB-4223-01A	NAALADL2	chr3	175455187	-	DRD3	chr3	113858543	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P35462	DB00391	Sulpiride	Antagonist	Small molecule	Approved\|Investigational
P35462	DB00409	Remoxipride	Antagonist	Small molecule	Approved\|Withdrawn
P35462	DB00502	Haloperidol	Inverse agonist	Small molecule	Approved
P35462	DB00714	Apomorphine	Agonist	Small molecule	Approved\|Investigational
P35462	DB01100	Pimozide	Antagonist	Small molecule	Approved
P35462	DB01184	Domperidone	Antagonist	Small molecule	Approved\|Investigational\|Vet_approved
P35462	DB01239	Chlorprothixene	Antagonist	Small molecule	Approved\|Experimental\|Investigational\|Withdrawn
P35462	DB01267	Paliperidone	Antagonist	Small molecule	Approved
P35462	DB01392	Yohimbine	Antagonist	Small molecule	Approved\|Investigational\|Vet_approved
P35462	DB05766	ACP-104		Small molecule	Investigational
P35462	DB06288	Amisulpride	Antagonist	Small molecule	Approved\|Investigational
P35462	DB06454	Sarizotan	Ligand	Small molecule	Investigational
P35462	DB09014	Captodiame	Agonist	Small molecule	Experimental
P35462	DB09207	AS-8112	Antagonist	Small molecule	Experimental
P35462	DB09223	Blonanserin	Antagonist	Small molecule	Investigational
P35462	DB09286	Pipamperone		Small molecule	Investigational
P35462	DB09289	Tianeptine	Agonist	Small molecule	Investigational
P35462	DB11274	Dihydro-alpha-ergocryptine	Partial agonist	Small molecule	Approved
P35462	DB12478	Piribedil		Small molecule	Investigational
P35462	DB13025	Tiapride	Blocker	Small molecule	Investigational
P35462	DB00391	Sulpiride	Antagonist
P35462	DB00409	Remoxipride	Antagonist
P35462	DB00502	Haloperidol	Inverse agonist
P35462	DB00714	Apomorphine	Agonist
P35462	DB01100	Pimozide	Antagonist
P35462	DB01184	Domperidone	Antagonist
P35462	DB01239	Chlorprothixene	Antagonist
P35462	DB01267	Paliperidone	Antagonist
P35462	DB01392	Yohimbine	Antagonist
P35462	DB05766	ACP-104
P35462	DB06288	Amisulpride	Antagonist
P35462	DB06454	Sarizotan	Ligand
P35462	DB09014	Captodiame	Agonist
P35462	DB09207	AS-8112	Antagonist
P35462	DB09223	Blonanserin	Antagonist
P35462	DB09286	Pipamperone
P35462	DB09289	Tianeptine	Agonist
P35462	DB11274	Dihydro-alpha-ergocryptine	Partial agonist
P35462	DB12478	Piribedil
P35462	DB13025	Tiapride	Blocker

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0600427	Cocaine Dependence	7	CTD_human;PSYGENET
C0009171	Cocaine Abuse	6	CTD_human;PSYGENET
C0001973	Alcoholic Intoxication, Chronic	5	PSYGENET
C0005586	Bipolar Disorder	5	PSYGENET
C0011570	Mental Depression	5	PSYGENET
C0011581	Depressive disorder	5	PSYGENET
C0041696	Unipolar Depression	5	PSYGENET
C1269683	Major Depressive Disorder	5	PSYGENET
C0021776	Intermittent Explosive Disorder	3	CTD_human
C0011206	Delirium	2	PSYGENET
C0004352	Autistic Disorder	1	CTD_human
C0013386	Dyskinesia, Drug-Induced	1	CTD_human
C0022333	Jacksonian Seizure	1	CTD_human
C0030662	Gambling, Pathological	1	CTD_human
C0036341	Schizophrenia	1	CTD_human
C0040517	Gilles de la Tourette syndrome	1	CTD_human
C0085762	Alcohol abuse	1	PSYGENET
C0149958	Complex partial seizures	1	CTD_human
C0221480	Recurrent depression	1	PSYGENET
C0234533	Generalized seizures	1	CTD_human
C0234535	Clonic Seizures	1	CTD_human
C0236804	Amphetamine Addiction	1	CTD_human
C0236807	Amphetamine Abuse	1	CTD_human
C0266487	Etat Marbre	1	CTD_human
C0270824	Visual seizure	1	CTD_human
C0270846	Epileptic drop attack	1	CTD_human
C0494475	Tonic - clonic seizures	1	CTD_human
C0750951	Lenticulostriate Disorders	1	CTD_human
C0751110	Single Seizure	1	CTD_human