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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DRG2 (NCBI Gene ID:1819)

Gene Summary

Gene Summary

Gene Information	Gene Name: DRG2
	Gene ID: 1819
	Gene Symbol	DRG2
	Gene ID	1819
	Gene Name	developmentally regulated GTP binding protein 2
	Synonyms	-
	Cytomap	17p11.2
	Type of Gene	protein-coding
	Description	developmentally-regulated GTP-binding protein 2TRAFAC GTPase DRG2translation factor GTPase DRG2
	Modification date	20200313
	UniProtAcc	P55039

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DRG2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'DRG2[title] AND translation [title] AND human.'

Gene	Title	PMID
DRG2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000225729	18001583	18001673	In-frame
ENST00000225729	18002330	18002391	Frame-shift
ENST00000225729	18002946	18003037	Frame-shift
ENST00000225729	18005234	18005311	Frame-shift
ENST00000225729	18009746	18009800	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000225729	18001583	18001673	1981	364	453	364	75	105
ENST00000225729	18009746	18009800	1981	1093	1146	364	318	336

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P55039	318	336	1	364	Chain	ID=PRO_0000205427;Note=Developmentally-regulated GTP-binding protein 2
P55039	75	105	1	364	Chain	ID=PRO_0000205427;Note=Developmentally-regulated GTP-binding protein 2
P55039	75	105	63	288	Domain	Note=OBG-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01047
P55039	75	105	69	76	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01047

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	DRG2	1.55172876221269	5.83844264602967e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
DLBC	DRG2	0.043335894	0.021309106
STAD	DRG2	-0.103741231	0.046055582

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DRG2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Epifactor	DRG2	SIRT6	0.815085204	1.77E-12
DLBC	IUPHAR	DRG2	SIRT6	0.815085204	1.77E-12
DLBC	TSG	DRG2	SIRT6	0.815085204	1.77E-12
KICH	IUPHAR	DRG2	CSNK2B	0.80340353	9.52E-22
THCA	Epifactor	DRG2	CCDC101	0.808551943	2.19E-133
THCA	Epifactor	DRG2	PRPF31	0.814171159	1.08E-136
THCA	Epifactor	DRG2	RUVBL2	0.82230492	1.10E-141
THCA	Epifactor	DRG2	DMAP1	0.830283413	7.82E-147
THYM	Cell metabolism gene	DRG2	PSMD9	0.810733093	1.11E-29
THYM	Cell metabolism gene	DRG2	PSMB6	0.842310029	5.30E-34
THYM	Cell metabolism gene	DRG2	SLC25A11	0.859453946	9.08E-37
THYM	Cell metabolism gene	DRG2	TIMM22	0.876194263	7.57E-40
THYM	Epifactor	DRG2	MCRS1	0.806251474	3.93E-29
THYM	Epifactor	DRG2	PELP1	0.833211671	1.15E-32
THYM	Epifactor	DRG2	C17orf49	0.845224326	1.90E-34
THYM	IUPHAR	DRG2	PSMB6	0.842310029	5.30E-34
THYM	IUPHAR	DRG2	SLC25A11	0.859453946	9.08E-37
THYM	TSG	DRG2	PFN1	0.823751809	2.34E-31
UCS	Cell metabolism gene	DRG2	PSMD9	0.810733093	1.11E-29
UCS	Cell metabolism gene	DRG2	PSMB6	0.842310029	5.30E-34
UCS	Cell metabolism gene	DRG2	SLC25A11	0.859453946	9.08E-37
UCS	Cell metabolism gene	DRG2	TIMM22	0.876194263	7.57E-40
UCS	Epifactor	DRG2	MCRS1	0.806251474	3.93E-29
UCS	Epifactor	DRG2	PELP1	0.833211671	1.15E-32
UCS	Epifactor	DRG2	C17orf49	0.845224326	1.90E-34
UCS	IUPHAR	DRG2	PSMB6	0.842310029	5.30E-34
UCS	IUPHAR	DRG2	SLC25A11	0.859453946	9.08E-37
UCS	TSG	DRG2	PFN1	0.823751809	2.34E-31
UVM	Cell metabolism gene	DRG2	PIGT	0.803742671	2.87E-19
UVM	Cell metabolism gene	DRG2	SLC25A11	0.814663197	3.84E-20
UVM	IUPHAR	DRG2	SLC25A11	0.814663197	3.84E-20
UVM	IUPHAR	DRG2	RNPEPL1	0.843772266	8.82E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	DRG2	RPL3	2.43523389101044	0.00016188295558095
PRAD	DRG2	GCN1L1	-7.54173196078564	0.000376184722398862
THCA	DRG2	ZCCHC4	-2.660987769927	0.000454814345944463
LIHC	DRG2	RPL8	-4.84588284974558	0.00110314154326131
KIRC	DRG2	GCN1L1	1.52944128066025	0.00150654978717842
PRAD	DRG2	ZCCHC4	-2.08636372976673	0.00214742919200666
KICH	DRG2	EAPP	-1.95104920096508	0.0027848482131958
KICH	DRG2	ZCCHC4	1.88632117214692	0.00507164001464844
HNSC	DRG2	RQCD1	1.97297540658491	0.00585215220849023
STAD	DRG2	ZC3H15	-1.04968618173197	0.00733334058895707
ESCA	DRG2	RWDD1	1.43074573953025	0.009765625
LUAD	DRG2	RPS4X	-2.43594282676366	0.0163893452361939
BLCA	DRG2	ZC3H15	1.07480871713981	0.0258216857910156
PRAD	DRG2	RWDD1	-1.37015889011473	0.0291755363147523
ESCA	DRG2	RPL3	1.12882976357497	0.0322265625
HNSC	DRG2	ZCCHC4	1.3543554542248	0.0398225729220485
KIRC	DRG2	RPS4X	-1.64140073680063	1.72010286166321e-07
LIHC	DRG2	GCN1L1	-1.50546993282376	2.24402029682138e-06
BRCA	DRG2	ZCCHC4	-3.0235646950969	2.91508621588365e-09
BRCA	DRG2	RWDD1	-1.13785288766259	3.18183978181012e-05
BRCA	DRG2	RPS4X	-1.55343710903986	3.36588066248297e-09
KIRC	DRG2	RPL8	-1.18252459971773	5.64962994208288e-07
LUAD	DRG2	GCN1L1	-3.11494072871482	5.86248556550202e-05
KIRP	DRG2	RPL8	-1.53003692350119	6.0301274061203e-05
COAD	DRG2	EAPP	-2.73707864334655	6.03199005126954e-05
THCA	DRG2	RPS4X	1.49777877118816	6.68348444344278e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DRG2

RWDD1, RSBN1L, ADSL, API5, EHD1, NT5C2, UBE2R2, HSPA8, DDX55, CEP170, SCLT1, XPO1, CUL1, SKP1, NR2C2, DYNLRB1, TRIM28, EIF4A3, TSSK3, NAB2, JMJD7, HSCB, TRIM54, MKI67, DNAJC2, DNAJC1, FKBP5, HSPA14, TMX3, IARS2, RCN2, DHPS, ACADSB, DDR1, TNFRSF1B, KCNE3, MAPK13, EP300, TOLLIP,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DRG2	chr17	18001679	TG	T	Deletion	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRG2	chr17	18003919	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRG2	chr17	18004862	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRG2	chr17	18010536	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DRG2	STAD	chr17	17997175	17997175	G	T	Missense_Mutation	p.R38L	4
DRG2	PAAD	chr17	18007126	18007126	A	C	Missense_Mutation	p.K273T	3
DRG2	UCEC	chr17	18003953	18003953	A	G	Missense_Mutation	p.Q204R	3
DRG2	STAD	chr17	17997175	17997175	G	T	Missense_Mutation		3
DRG2	PAAD	chr17	18002358	18002358	G	A	Missense_Mutation	p.D115N	3
DRG2	PAAD	chr17	18003681	18003681	C	T	Silent	p.L158L	3
DRG2	LUAD	chr17	18002385	18002385	G	A	Missense_Mutation	p.A124T	2
DRG2	CHOL	chr17	18009784	18009784	A	C	Missense_Mutation	p.K331T	2
DRG2	UCEC	chr17	18010542	18010542	C	T	Silent	p.I361	2
DRG2	STAD	chr17	17997252	17997252	C	T	Missense_Mutation	p.R64C	2
DRG2	BLCA	chr17	17997132	17997132	G	A	Missense_Mutation	p.E24K	2
DRG2	STAD	chr17	18004893	18004893	C	T	Missense_Mutation	p.P240S	2
DRG2	BLCA	chr17	18005268	18005268	G	A	Missense_Mutation	p.E255K	2
DRG2	SKCM	chr17	18004859	18004859	C	T	Silent	p.F228F	2
DRG2	BLCA	chr17	18004839	18004839	G	C	Missense_Mutation	p.D222H	2
DRG2	PAAD	chr17	18002358	18002358	G	A	Missense_Mutation		2
DRG2	BRCA	chr17	17997277	17997277	C	G	Missense_Mutation	p.S72C	2
DRG2	PAAD	chr17	18007126	18007126	A	C	Missense_Mutation		2
DRG2	STAD	chr17	18009790	18009790	C	T	Missense_Mutation	p.A333V	2
DRG2	LIHC	chr17	18003031	18003031	T	C	Splice_Site		2
DRG2	STAD	chr17	18003967	18003967	G	A	Missense_Mutation	p.E209K	2
DRG2	LIHC	chr17	18003031	18003031	T	C	Missense_Mutation	p.V154A	2
DRG2	UCEC	chr17	18001619	18001619	C	T	Silent	p.S87	2
DRG2	LIHC	chr17	18001657	18001657	T	-	Frame_Shift_Del	p.I100fs	2
DRG2	CHOL	chr17	18009784	18009784	A	C	Missense_Mutation		2
DRG2	UCEC	chr17	18005252	18005252	C	A	Missense_Mutation	p.D249E	2
DRG2	GBM	chr17	18007951	18007951	A	T	Missense_Mutation		1
DRG2	STAD	chr17	18010524	18010524	T	C	Silent	p.H355H	1
DRG2	STAD	chr17	18005286	18005286	C	T	Nonsense_Mutation	p.R261*	1
DRG2	BLCA	chr17	18003719	18003719	C	T	Silent		1
DRG2	PRAD	chr17	18001642	18001642	C	T	Missense_Mutation	p.T95I	1
DRG2	GBM	chr17	18004863	18004863	G	A	Missense_Mutation		1
DRG2	STAD	chr17	18002386	18002386	C	T	Missense_Mutation	p.A124V	1
DRG2	LUAD	chr17	17997126	17997126	G	A	Splice_Site		1
DRG2	COAD	chr17	18003703	18003703	C	T	Missense_Mutation	p.S165F	1
DRG2	SKCM	chr17	18007134	18007134	C	T	Silent	p.L276L	1
DRG2	KIRC	chr17	17997213	17997213	A	-	Frame_Shift_Del	p.S50fs	1
DRG2	STAD	chr17	17997255	17997255	G	A	Missense_Mutation	p.V65M	1
DRG2	LUAD	chr17	17997259	17997259	C	T	Missense_Mutation	p.A66V	1
DRG2	COAD	chr17	18003749	18003749	G	A	Silent	p.K180K	1
DRG2	KIRP	chr17	18003957	18003957	C	A	Silent		1
DRG2	STAD	chr17	18010553	18010553	A	G	Silent	p.X365X	1
DRG2	STAD	chr17	18005257	18005257	T	C	Missense_Mutation	p.I251T	1
DRG2	OV	chr17	17944642	17944645	CAGT	-	Frame_Shift_Del		1
DRG2	COAD	chr17	18003881	18003881	A	G	Splice_Site	.	1
DRG2	SKCM	chr17	18004832	18004832	C	T	Silent	p.F219F	1
DRG2	LGG	chr17	18004806	18004806	G	T	Splice_Site		1
DRG2	STAD	chr17	18010553	18010553	A	G	Silent	p.365	1
DRG2	BLCA	chr17	18005255	18005255	G	A	Silent	p.Q250Q	1
DRG2	OV	chr17	17944625	17944625	C	A	Silent	p.G186	1
DRG2	COAD	chr17	18005258	18005258	C	T	Silent	p.I251I	1
DRG2	SKCM	chr17	18002954	18002954	C	T	Silent	p.G128G	1
DRG2	LIHC	chr17	18003902	18003902	T	C	Missense_Mutation		1
DRG2	STAD	chr17	18010524	18010524	T	C	Nonstop_Mutation		1
DRG2	BLCA	chr17	18003719	18003719	C	T	Silent	p.L170L	1
DRG2	COAD	chr17	18009754	18009754	G	A	Missense_Mutation	p.R321H	1
DRG2	SKCM	chr17	18010530	18010530	C	T	Silent	p.D357D	1
DRG2	BLCA	chr17	17997132	17997132	G	A	Missense_Mutation		1
DRG2	LIHC	chr17	18003724	18003724	A	T	Missense_Mutation		1
DRG2	THCA	chr17	18003714	18003714	C	A	Missense_Mutation		1
DRG2	COAD	chr17	17991394	17991395	-	AA	Frame_Shift_Ins	p.K19fs	1
DRG2	SKCM	chr17	18007134	18007134	C	T	Missense_Mutation	p.P82L	1
DRG2	BLCA	chr17	18004839	18004839	G	C	Missense_Mutation		1
DRG2	LIHC	chr17	18003675	18003675	A	G	Splice_Site		1
DRG2	CESC	chr17	17997209	17997209	G	A	Silent		1
DRG2	PAAD	chr17	18003681	18003681	C	T	Silent		1
DRG2	UCEC	chr17	18003892	18003892	G	T	Missense_Mutation	p.G184C	1
DRG2	DLBC	chr17	18003919	18003919	G	A	Missense_Mutation	p.V193I	1
DRG2	SKCM	chr17	18010489	18010489	C	T	Missense_Mutation	p.P344S	1
DRG2	BLCA	chr17	18005268	18005268	G	A	Missense_Mutation		1
DRG2	CESC	chr17	18010473	18010473	C	A	Missense_Mutation		1
DRG2	DLBC	chr17	18003008	18003008	G	A	Missense_Mutation	p.M146I	1
DRG2	BLCA	chr17	18005255	18005255	G	A	Silent		1
DRG2	CESC	chr17	18002969	18002969	G	T	Silent		1
DRG2	GBM	chr17	18007951	18007951	A	T	Missense_Mutation	p.T304S	1
DRG2	STAD	chr17	18010524	18010524	T	C	Nonstop_Mutation	p.*162R	1
DRG2	BLCA	chr17	18010519	18010519	G	A	Missense_Mutation		1

Copy number variation (CNV) of DRG2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DRG2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
47287	STAD	TCGA-BR-A4QI-01A	ALKBH5	chr17	18098349	+	DRG2	chr17	18009747	+
24167	BRCA	TCGA-EW-A1OZ-01A	DRG2	chr17	17997287	+	ZNF624	chr17	16527823	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	DRG2	0.000357100795738186	0.01
SKCM	DRG2	0.00252248193914247	0.068
LIHC	DRG2	0.00595089677171073	0.15

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	DRG2	0.0269284781703598	0.83
LGG	DRG2	1.22502539955296e-10	4e-09
ESCA	DRG2	0.0108754903878405	0.35

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source