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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF4A1 (NCBI Gene ID:1973)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF4A1
	Gene ID: 1973
	Gene Symbol	EIF4A1
	Gene ID	1973
	Gene Name	eukaryotic translation initiation factor 4A1
	Synonyms	DDX2A\|EIF-4A\|EIF4A\|eIF-4A-I\|eIF4A-I
	Cytomap	17p13.1
	Type of Gene	protein-coding
	Description	eukaryotic initiation factor 4A-IATP-dependent RNA helicase eIF4A-1eukaryotic initiation factor 4AIeukaryotic translation initiation factor 4A
	Modification date	20200322
	UniProtAcc	P60842

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF4A1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF4A1[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF4A1	Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity	29844128

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000293831	7477577	7477626	Frame-shift
ENST00000293831	7477863	7477996	Frame-shift
ENST00000293831	7478436	7478576	Frame-shift
ENST00000293831	7479841	7480010	Frame-shift
ENST00000293831	7480661	7480805	In-frame
ENST00000293831	7480886	7481024	In-frame
ENST00000293831	7481482	7481562	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000293831	7480661	7480805	1773	641	784	406	208	256
ENST00000293831	7480886	7481024	1773	785	922	406	256	302

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P60842	208	256	2	406	Chain	ID=PRO_0000054933;Note=Eukaryotic initiation factor 4A-I
P60842	256	302	2	406	Chain	ID=PRO_0000054933;Note=Eukaryotic initiation factor 4A-I
P60842	208	256	63	234	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
P60842	208	256	245	406	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00542
P60842	256	302	245	406	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00542
P60842	208	256	238	238	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P60843
P60842	208	256	225	225	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P60842	208	256	238	238	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P60842	208	256	208	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2G9N
P60842	208	256	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2G9N
P60842	208	256	225	227	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EIQ
P60842	208	256	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2G9N
P60842	208	256	241	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
P60842	208	256	246	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
P60842	208	256	256	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
P60842	256	302	256	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
P60842	256	302	273	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
P60842	256	302	282	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
P60842	256	302	291	296	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
P60842	256	302	300	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EIQ

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	EIF4A1	-1.24538073199285	0.0419921875
KICH	EIF4A1	1.14485583309571	8.16583633422851e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
COAD	EIF4A1	0.031247286	0.025827107
STAD	EIF4A1	-0.085886935	0.031993062
DLBC	EIF4A1	0.030716818	0.046492682

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF4A1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	Cell metabolism gene	EIF4A1	UCK2	0.801592184	1.37E-21
KICH	Cell metabolism gene	EIF4A1	HAS2	0.828271532	4.14E-24
KICH	CGC	EIF4A1	LMNA	0.801215174	1.48E-21
KICH	CGC	EIF4A1	TPM4	0.802310901	1.19E-21
KICH	IUPHAR	EIF4A1	STK17B	0.813291775	1.21E-22
KICH	IUPHAR	EIF4A1	IL4R	0.817788548	4.53E-23
KICH	IUPHAR	EIF4A1	HRH1	0.818514895	3.86E-23
KICH	IUPHAR	EIF4A1	GPR153	0.818877475	3.56E-23
KICH	Kinase	EIF4A1	STK17B	0.813291775	1.21E-22
KICH	TSG	EIF4A1	PFN1	0.81295582	1.30E-22
TGCT	Cell metabolism gene	EIF4A1	PSMB6	0.804222718	1.26E-36
TGCT	Cell metabolism gene	EIF4A1	TEAD4	0.811598975	8.89E-38
TGCT	Cell metabolism gene	EIF4A1	NUP88	0.82744013	1.97E-40
TGCT	CGC	EIF4A1	HMGA1	0.81060389	1.28E-37
TGCT	IUPHAR	EIF4A1	PSMB6	0.804222718	1.26E-36
TGCT	TF	EIF4A1	HMGA1	0.81060389	1.28E-37
TGCT	TF	EIF4A1	TEAD4	0.811598975	8.89E-38
THYM	Cell metabolism gene	EIF4A1	PHKG2	0.800087333	2.11E-28
THYM	Cell metabolism gene	EIF4A1	PGP	0.801524339	1.43E-28
THYM	Cell metabolism gene	EIF4A1	ACOT8	0.802929587	9.79E-29
THYM	Cell metabolism gene	EIF4A1	TSTA3	0.803020064	9.55E-29
THYM	Cell metabolism gene	EIF4A1	SEC61G	0.805111237	5.38E-29
THYM	Cell metabolism gene	EIF4A1	TOMM22	0.806030857	4.18E-29
THYM	Cell metabolism gene	EIF4A1	TUBA1C	0.806254749	3.92E-29
THYM	Cell metabolism gene	EIF4A1	NME1	0.806563127	3.60E-29
THYM	Cell metabolism gene	EIF4A1	NANS	0.807694744	2.63E-29
THYM	Cell metabolism gene	EIF4A1	EBP	0.807948173	2.45E-29
THYM	Cell metabolism gene	EIF4A1	TOMM40	0.809547615	1.56E-29
THYM	Cell metabolism gene	EIF4A1	TBCB	0.810882367	1.07E-29
THYM	Cell metabolism gene	EIF4A1	DGUOK	0.812610514	6.50E-30
THYM	Cell metabolism gene	EIF4A1	SLC27A5	0.812672009	6.38E-30
THYM	Cell metabolism gene	EIF4A1	GEMIN7	0.812734139	6.27E-30
THYM	Cell metabolism gene	EIF4A1	EXOSC4	0.813827549	4.57E-30
THYM	Cell metabolism gene	EIF4A1	GALK1	0.814915531	3.33E-30
THYM	Cell metabolism gene	EIF4A1	SRM	0.815527161	2.78E-30
THYM	Cell metabolism gene	EIF4A1	POLA2	0.817333122	1.63E-30
THYM	Cell metabolism gene	EIF4A1	LSM3	0.819268951	9.16E-31
THYM	Cell metabolism gene	EIF4A1	AAAS	0.819633386	8.21E-31
THYM	Cell metabolism gene	EIF4A1	PMPCA	0.820486479	6.35E-31
THYM	Cell metabolism gene	EIF4A1	PSMB6	0.821409382	4.80E-31
THYM	Cell metabolism gene	EIF4A1	POLD2	0.822029917	3.97E-31
THYM	Cell metabolism gene	EIF4A1	CCT7	0.822593	3.34E-31
THYM	Cell metabolism gene	EIF4A1	PSMA6	0.823188374	2.78E-31
THYM	Cell metabolism gene	EIF4A1	EXOSC5	0.823378251	2.63E-31
THYM	Cell metabolism gene	EIF4A1	PSME1	0.823984674	2.18E-31
THYM	Cell metabolism gene	EIF4A1	PSMB2	0.825380255	1.41E-31
THYM	Cell metabolism gene	EIF4A1	POLR2H	0.829319	4.07E-32
THYM	Cell metabolism gene	EIF4A1	POLD1	0.831542086	1.99E-32
THYM	Cell metabolism gene	EIF4A1	PSMB7	0.832374894	1.52E-32
THYM	Cell metabolism gene	EIF4A1	FPGS	0.83284998	1.30E-32
THYM	Cell metabolism gene	EIF4A1	PSMB3	0.833940125	9.07E-33
THYM	Cell metabolism gene	EIF4A1	TIMM13	0.8371049	3.16E-33
THYM	Cell metabolism gene	EIF4A1	SNRPB	0.837255011	3.00E-33
THYM	Cell metabolism gene	EIF4A1	HMBS	0.837613106	2.66E-33
THYM	Cell metabolism gene	EIF4A1	DGKZ	0.840370182	1.04E-33
THYM	Cell metabolism gene	EIF4A1	PAFAH1B3	0.840905807	8.64E-34
THYM	Cell metabolism gene	EIF4A1	TIMM8B	0.842290486	5.34E-34
THYM	Cell metabolism gene	EIF4A1	PSMA5	0.844852304	2.17E-34
THYM	Cell metabolism gene	EIF4A1	PSMA4	0.845847597	1.52E-34
THYM	Cell metabolism gene	EIF4A1	LSM2	0.848663465	5.49E-35
THYM	Cell metabolism gene	EIF4A1	SNRPD2	0.853394493	9.46E-36
THYM	Cell metabolism gene	EIF4A1	PSMC3	0.85347557	9.18E-36
THYM	Cell metabolism gene	EIF4A1	PSMD13	0.858916312	1.12E-36
THYM	Cell metabolism gene	EIF4A1	SNRPE	0.861209652	4.51E-37
THYM	Cell metabolism gene	EIF4A1	LSM4	0.864501342	1.18E-37
THYM	Cell metabolism gene	EIF4A1	SNRPD1	0.866049796	6.23E-38
THYM	Cell metabolism gene	EIF4A1	POLR3K	0.872301021	4.30E-39
THYM	Cell metabolism gene	EIF4A1	NOP56	0.889117488	1.51E-42
THYM	Cell metabolism gene	EIF4A1	DTYMK	0.911004072	5.48E-48
THYM	CGC	EIF4A1	CDK4	0.806970416	3.22E-29
THYM	CGC	EIF4A1	TFPT	0.81501025	3.24E-30
THYM	CGC	EIF4A1	POLD1	0.831542086	1.99E-32
THYM	CGC	EIF4A1	SDHAF2	0.872296011	4.31E-39
THYM	Epifactor	EIF4A1	HDGF	0.804592281	6.21E-29
THYM	Epifactor	EIF4A1	SIRT7	0.811076653	1.01E-29
THYM	Epifactor	EIF4A1	PRMT1	0.812919682	5.94E-30
THYM	Epifactor	EIF4A1	EXOSC4	0.813827549	4.57E-30
THYM	Epifactor	EIF4A1	TFPT	0.81501025	3.24E-30
THYM	Epifactor	EIF4A1	TAF10	0.815429868	2.86E-30
THYM	Epifactor	EIF4A1	RRP8	0.816131037	2.33E-30
THYM	Epifactor	EIF4A1	MAZ	0.818614434	1.11E-30
THYM	Epifactor	EIF4A1	CXXC1	0.823287036	2.70E-31
THYM	Epifactor	EIF4A1	EXOSC5	0.823378251	2.63E-31
THYM	Epifactor	EIF4A1	TRIM28	0.827540333	7.17E-32
THYM	Epifactor	EIF4A1	FBL	0.828881313	4.68E-32
THYM	Epifactor	EIF4A1	MCRS1	0.828986624	4.53E-32
THYM	Epifactor	EIF4A1	BRMS1	0.834409491	7.77E-33
THYM	Epifactor	EIF4A1	RUVBL2	0.836860305	3.43E-33
THYM	Epifactor	EIF4A1	C17orf49	0.845462405	1.74E-34
THYM	Epifactor	EIF4A1	NAP1L4	0.859548634	8.75E-37
THYM	Epifactor	EIF4A1	PPP4C	0.867080946	4.05E-38
THYM	Epifactor	EIF4A1	PPM1G	0.879627134	1.56E-40
THYM	IUPHAR	EIF4A1	PHKG2	0.800087333	2.11E-28
THYM	IUPHAR	EIF4A1	CDK4	0.806970416	3.22E-29
THYM	IUPHAR	EIF4A1	SIRT7	0.811076653	1.01E-29
THYM	IUPHAR	EIF4A1	TOP1MT	0.812414751	6.87E-30
THYM	IUPHAR	EIF4A1	SLC27A5	0.812672009	6.38E-30
THYM	IUPHAR	EIF4A1	PRMT1	0.812919682	5.94E-30
THYM	IUPHAR	EIF4A1	PSMB6	0.821409382	4.80E-31
THYM	IUPHAR	EIF4A1	PSMB2	0.825380255	1.41E-31
THYM	IUPHAR	EIF4A1	TRIM28	0.827540333	7.17E-32
THYM	IUPHAR	EIF4A1	MPDU1	0.84084015	8.84E-34
THYM	IUPHAR	EIF4A1	ECE2	0.84596012	1.46E-34
THYM	IUPHAR	EIF4A1	MFSD2B	0.852551133	1.30E-35
THYM	Kinase	EIF4A1	PHKG2	0.800087333	2.11E-28
THYM	Kinase	EIF4A1	CDK4	0.806970416	3.22E-29
THYM	Kinase	EIF4A1	TRIM28	0.827540333	7.17E-32
THYM	TF	EIF4A1	USF1	0.814921023	3.32E-30
THYM	TF	EIF4A1	MAZ	0.818614434	1.11E-30
THYM	TF	EIF4A1	GTF3A	0.818644569	1.10E-30
THYM	TF	EIF4A1	CXXC1	0.823287036	2.70E-31
THYM	TF	EIF4A1	PIN1	0.834814129	6.80E-33
THYM	TF	EIF4A1	NAIF1	0.840137841	1.13E-33
THYM	TF	EIF4A1	ZNF668	0.859497096	8.93E-37
THYM	TSG	EIF4A1	TSSC4	0.800406549	1.94E-28
THYM	TSG	EIF4A1	NME1	0.806563127	3.60E-29
THYM	TSG	EIF4A1	BRMS1	0.834409491	7.77E-33
THYM	TSG	EIF4A1	PIN1	0.834814129	6.80E-33
THYM	TSG	EIF4A1	ZNF668	0.859497096	8.93E-37
THYM	TSG	EIF4A1	PFN1	0.870169919	1.09E-38
UCS	Cell metabolism gene	EIF4A1	PHKG2	0.800087333	2.11E-28
UCS	Cell metabolism gene	EIF4A1	PGP	0.801524339	1.43E-28
UCS	Cell metabolism gene	EIF4A1	ACOT8	0.802929587	9.79E-29
UCS	Cell metabolism gene	EIF4A1	TSTA3	0.803020064	9.55E-29
UCS	Cell metabolism gene	EIF4A1	SEC61G	0.805111237	5.38E-29
UCS	Cell metabolism gene	EIF4A1	TOMM22	0.806030857	4.18E-29
UCS	Cell metabolism gene	EIF4A1	TUBA1C	0.806254749	3.92E-29
UCS	Cell metabolism gene	EIF4A1	NME1	0.806563127	3.60E-29
UCS	Cell metabolism gene	EIF4A1	NANS	0.807694744	2.63E-29
UCS	Cell metabolism gene	EIF4A1	EBP	0.807948173	2.45E-29
UCS	Cell metabolism gene	EIF4A1	TOMM40	0.809547615	1.56E-29
UCS	Cell metabolism gene	EIF4A1	TBCB	0.810882367	1.07E-29
UCS	Cell metabolism gene	EIF4A1	DGUOK	0.812610514	6.50E-30
UCS	Cell metabolism gene	EIF4A1	SLC27A5	0.812672009	6.38E-30
UCS	Cell metabolism gene	EIF4A1	GEMIN7	0.812734139	6.27E-30
UCS	Cell metabolism gene	EIF4A1	EXOSC4	0.813827549	4.57E-30
UCS	Cell metabolism gene	EIF4A1	GALK1	0.814915531	3.33E-30
UCS	Cell metabolism gene	EIF4A1	SRM	0.815527161	2.78E-30
UCS	Cell metabolism gene	EIF4A1	POLA2	0.817333122	1.63E-30
UCS	Cell metabolism gene	EIF4A1	LSM3	0.819268951	9.16E-31
UCS	Cell metabolism gene	EIF4A1	AAAS	0.819633386	8.21E-31
UCS	Cell metabolism gene	EIF4A1	PMPCA	0.820486479	6.35E-31
UCS	Cell metabolism gene	EIF4A1	PSMB6	0.821409382	4.80E-31
UCS	Cell metabolism gene	EIF4A1	POLD2	0.822029917	3.97E-31
UCS	Cell metabolism gene	EIF4A1	CCT7	0.822593	3.34E-31
UCS	Cell metabolism gene	EIF4A1	PSMA6	0.823188374	2.78E-31
UCS	Cell metabolism gene	EIF4A1	EXOSC5	0.823378251	2.63E-31
UCS	Cell metabolism gene	EIF4A1	PSME1	0.823984674	2.18E-31
UCS	Cell metabolism gene	EIF4A1	PSMB2	0.825380255	1.41E-31
UCS	Cell metabolism gene	EIF4A1	POLR2H	0.829319	4.07E-32
UCS	Cell metabolism gene	EIF4A1	POLD1	0.831542086	1.99E-32
UCS	Cell metabolism gene	EIF4A1	PSMB7	0.832374894	1.52E-32
UCS	Cell metabolism gene	EIF4A1	FPGS	0.83284998	1.30E-32
UCS	Cell metabolism gene	EIF4A1	PSMB3	0.833940125	9.07E-33
UCS	Cell metabolism gene	EIF4A1	TIMM13	0.8371049	3.16E-33
UCS	Cell metabolism gene	EIF4A1	SNRPB	0.837255011	3.00E-33
UCS	Cell metabolism gene	EIF4A1	HMBS	0.837613106	2.66E-33
UCS	Cell metabolism gene	EIF4A1	DGKZ	0.840370182	1.04E-33
UCS	Cell metabolism gene	EIF4A1	PAFAH1B3	0.840905807	8.64E-34
UCS	Cell metabolism gene	EIF4A1	TIMM8B	0.842290486	5.34E-34
UCS	Cell metabolism gene	EIF4A1	PSMA5	0.844852304	2.17E-34
UCS	Cell metabolism gene	EIF4A1	PSMA4	0.845847597	1.52E-34
UCS	Cell metabolism gene	EIF4A1	LSM2	0.848663465	5.49E-35
UCS	Cell metabolism gene	EIF4A1	SNRPD2	0.853394493	9.46E-36
UCS	Cell metabolism gene	EIF4A1	PSMC3	0.85347557	9.18E-36
UCS	Cell metabolism gene	EIF4A1	PSMD13	0.858916312	1.12E-36
UCS	Cell metabolism gene	EIF4A1	SNRPE	0.861209652	4.51E-37
UCS	Cell metabolism gene	EIF4A1	LSM4	0.864501342	1.18E-37
UCS	Cell metabolism gene	EIF4A1	SNRPD1	0.866049796	6.23E-38
UCS	Cell metabolism gene	EIF4A1	POLR3K	0.872301021	4.30E-39
UCS	Cell metabolism gene	EIF4A1	NOP56	0.889117488	1.51E-42
UCS	Cell metabolism gene	EIF4A1	DTYMK	0.911004072	5.48E-48
UCS	CGC	EIF4A1	CDK4	0.806970416	3.22E-29
UCS	CGC	EIF4A1	TFPT	0.81501025	3.24E-30
UCS	CGC	EIF4A1	POLD1	0.831542086	1.99E-32
UCS	CGC	EIF4A1	SDHAF2	0.872296011	4.31E-39
UCS	Epifactor	EIF4A1	HDGF	0.804592281	6.21E-29
UCS	Epifactor	EIF4A1	SIRT7	0.811076653	1.01E-29
UCS	Epifactor	EIF4A1	PRMT1	0.812919682	5.94E-30
UCS	Epifactor	EIF4A1	EXOSC4	0.813827549	4.57E-30
UCS	Epifactor	EIF4A1	TFPT	0.81501025	3.24E-30
UCS	Epifactor	EIF4A1	TAF10	0.815429868	2.86E-30
UCS	Epifactor	EIF4A1	RRP8	0.816131037	2.33E-30
UCS	Epifactor	EIF4A1	MAZ	0.818614434	1.11E-30
UCS	Epifactor	EIF4A1	CXXC1	0.823287036	2.70E-31
UCS	Epifactor	EIF4A1	EXOSC5	0.823378251	2.63E-31
UCS	Epifactor	EIF4A1	TRIM28	0.827540333	7.17E-32
UCS	Epifactor	EIF4A1	FBL	0.828881313	4.68E-32
UCS	Epifactor	EIF4A1	MCRS1	0.828986624	4.53E-32
UCS	Epifactor	EIF4A1	BRMS1	0.834409491	7.77E-33
UCS	Epifactor	EIF4A1	RUVBL2	0.836860305	3.43E-33
UCS	Epifactor	EIF4A1	C17orf49	0.845462405	1.74E-34
UCS	Epifactor	EIF4A1	NAP1L4	0.859548634	8.75E-37
UCS	Epifactor	EIF4A1	PPP4C	0.867080946	4.05E-38
UCS	Epifactor	EIF4A1	PPM1G	0.879627134	1.56E-40
UCS	IUPHAR	EIF4A1	PHKG2	0.800087333	2.11E-28
UCS	IUPHAR	EIF4A1	CDK4	0.806970416	3.22E-29
UCS	IUPHAR	EIF4A1	SIRT7	0.811076653	1.01E-29
UCS	IUPHAR	EIF4A1	TOP1MT	0.812414751	6.87E-30
UCS	IUPHAR	EIF4A1	SLC27A5	0.812672009	6.38E-30
UCS	IUPHAR	EIF4A1	PRMT1	0.812919682	5.94E-30
UCS	IUPHAR	EIF4A1	PSMB6	0.821409382	4.80E-31
UCS	IUPHAR	EIF4A1	PSMB2	0.825380255	1.41E-31
UCS	IUPHAR	EIF4A1	TRIM28	0.827540333	7.17E-32
UCS	IUPHAR	EIF4A1	MPDU1	0.84084015	8.84E-34
UCS	IUPHAR	EIF4A1	ECE2	0.84596012	1.46E-34
UCS	IUPHAR	EIF4A1	MFSD2B	0.852551133	1.30E-35
UCS	Kinase	EIF4A1	PHKG2	0.800087333	2.11E-28
UCS	Kinase	EIF4A1	CDK4	0.806970416	3.22E-29
UCS	Kinase	EIF4A1	TRIM28	0.827540333	7.17E-32
UCS	TF	EIF4A1	USF1	0.814921023	3.32E-30
UCS	TF	EIF4A1	MAZ	0.818614434	1.11E-30
UCS	TF	EIF4A1	GTF3A	0.818644569	1.10E-30
UCS	TF	EIF4A1	CXXC1	0.823287036	2.70E-31
UCS	TF	EIF4A1	PIN1	0.834814129	6.80E-33
UCS	TF	EIF4A1	NAIF1	0.840137841	1.13E-33
UCS	TF	EIF4A1	ZNF668	0.859497096	8.93E-37
UCS	TSG	EIF4A1	TSSC4	0.800406549	1.94E-28
UCS	TSG	EIF4A1	NME1	0.806563127	3.60E-29
UCS	TSG	EIF4A1	BRMS1	0.834409491	7.77E-33
UCS	TSG	EIF4A1	PIN1	0.834814129	6.80E-33
UCS	TSG	EIF4A1	ZNF668	0.859497096	8.93E-37
UCS	TSG	EIF4A1	PFN1	0.870169919	1.09E-38

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
HNSC	EIF4A1	EIF1	-4.13399438210909	0.000228392819053625
LUAD	EIF4A1	PDCD4	1.15931823826993	0.00162636946590219
BRCA	EIF4A1	EIF4G2	1.33801911881742	0.0018433651637361
BRCA	EIF4A1	EIF4G3	1.34206807761848	0.00309822300858815
CHOL	EIF4A1	PABPC1	-4.56272528815353	0.00390625
STAD	EIF4A1	EIF4G2	-4.30902559301167	0.0050255935639143
KICH	EIF4A1	EIF4G1	-1.46656081150743	0.00612920522689819
PRAD	EIF4A1	EIF1	1.32822648991353	0.00674237731133815
BLCA	EIF4A1	PABPC1	1.31485302792746	0.0180816650390625
READ	EIF4A1	PDCD4	-3.13328676129312	0.03125
LUAD	EIF4A1	EIF3B	-5.80435587546762	1.0542655358657e-09
HNSC	EIF4A1	PDCD4	-6.91824922290957	1.13186615635641e-09
THCA	EIF4A1	EIF4G3	-1.00361616225016	1.40000643717562e-05
LUAD	EIF4A1	EIF4G3	-4.21879885884405	2.22325471114907e-07
KIRC	EIF4A1	EIF3B	-1.56313263784517	2.35252849767166e-12
BRCA	EIF4A1	EIF4B	-2.16032742029696	2.35556737304054e-22
LIHC	EIF4A1	PABPC1	-1.72076961362188	2.98009622125841e-06
STAD	EIF4A1	EIF3B	-4.7724660972007	3.25962901115418e-08
LUSC	EIF4A1	EIF4G3	-4.43634473815109	3.64325144746635e-05
HNSC	EIF4A1	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	EIF4A1	EIF3B	-2.7592297042974	4.6566128730774e-09
KICH	EIF4A1	EIF4E	1.61675210562671	6.55651092529297e-06
KIRC	EIF4A1	EIF4B	1.14997140510474	7.59366366705366e-09
PRAD	EIF4A1	PABPC1	-2.10200318363476	8.55379952759014e-07
COAD	EIF4A1	PDCD4	-5.14091568352005	8.94069671630861e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF4A1

UPF2, EIF4G1, PDCD4, EIF3A, EIF4G3, EIF4E, EIF3B, EIF4G2, PAIP1, PABPC1, MEPCE, RPAP3, CHD1L, PRMT1, SRRM2, H2AFX, MYC, UCHL5, Mapk13, HDAC5, AI837181, Eif3a, Poc1b, Csnk1e, Cdk1, MAPK6, RAD21, CENPA, SIRT7, CUL3, CDK2, CUL1, COPS5, CAND1, AKT1, EIF4H, EIF4B, EIF4A2, RPSA, RPL8, RPL19, RPS26, EEF2, HSP90AB1, RPLP0P6, TMEM43, ABCC2, VDAC3, ZBTB43, ILF2, SDHA, ATP6V1A, HSPA5, EEF1A1, UQCRFS1, GPRC5A, NDUFB11, ATP5A1, ESR1, LIG4, FN1, VCAM1, ITGA4, CD81, NPM1, ADRB2, FBXO6, SH3RF2, TRAP1, STAU1, HUWE1, FUS, CUL7, OBSL1, CCDC8, UNK, MAEL, PNPT1, LAGE3, NFYB, NTRK1, IBTK, Eif3e, GAN, CRY1, CRY2, MCM2, Ksr1, CDC5L, U2AF2, WWP2, IBA57, EIF3H, EIF4A3, EIF3E, EIF3M, RPP25L, EIF3C, EIF4E3, EIF3D, KIF1B, EIF3I, TRIM25, G3BP1, FAM107A, HDAC6, EIF4A1, PDSS2, SNAPC1, TAF2, UBA3, ACLY, EGLN3, TMPO, OTUD6B, HSPA8, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, RPTOR, CHD3, CHD4, SPDL1, RIOK1, TNKS, PRKCZ, UBE3A, ZUFSP, ESR2, HEXIM1, SNAI1, AGR2, RECQL4, NEK2, METTL14, KIAA1429, RC3H1, RC3H2, ACTC1, ZBTB7A, PHB, FAF1, RBX1, ZC3H7A, NR2C2, UCHL3, XRCC6, CTCF, CD74, ANO7, BIRC3, LMBR1L, TRIM28, PPIA, SOX2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, NGB, HELLS, CASP9, LCK, MAP4K1, SH3GL3, ANKRD55, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF7b, ATXN2, DDX3X, EIF3G, IPO11, PABPC4, PRRC2A, PRRC2B, PRRC2C, TDRD3, TOP3B, UPF1, USP10, G3BP2, KIF1C, LSM12, CNOT3, EIF4ENIF1, YTHDF3, DUX4, DUX4L9, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, MAD2L2, KIF20A, KIF23, PRC1, FASN, HNRNPH1, SUMO2, NDN, Rnf183, BRD4, NINL, NUPR1, RBM45, CIC, UBR5, RBM39, LGALS9, USP15, OGT, AR, PARK2, UFL1, WDR77, PRMT5, FZR1, SPRTN, BTF3, FBXW7, NLRP7, LHPP, BSG, E, ORF10, ORF8, S, NBR1, CALCOCO2, SQSTM1, MAGEL2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF4A1	chr17	7478498	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
EIF4A1	chr17	7480879	A	G	single_nucleotide_variant	Uncertain_significance	See_cases	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF4A1	LIHC	chr17	7479969	7479969	C	-	Frame_Shift_Del	p.T158fs	3
EIF4A1	SKCM	chr17	7478546	7478546	C	T	Silent	p.V105V	2
EIF4A1	BLCA	chr17	7480991	7480991	G	T	Missense_Mutation	p.K291N	2
EIF4A1	SKCM	chr17	7479909	7479909	C	T	Missense_Mutation	p.T138I	2
EIF4A1	BLCA	chr17	7478464	7478464	C	G	Missense_Mutation	p.S78C	2
EIF4A1	SKCM	chr17	7479910	7479910	C	T	Silent	p.T138T	2
EIF4A1	KIRP	chr17	7478578	7478578	T	G	Splice_Site	.	2
EIF4A1	SKCM	chr17	7476169	7476169	A	T	Missense_Mutation	p.S4C	2
EIF4A1	LUAD	chr17	7480995	7480995	C	G	Missense_Mutation	p.H293D	2
EIF4A1	UCEC	chr17	7476181	7476181	C	T	Nonsense_Mutation	p.R8*	2
EIF4A1	UCEC	chr17	7478520	7478520	G	A	Missense_Mutation	p.D97N	2
EIF4A1	UCEC	chr17	7478537	7478537	G	A	Silent	p.Q102	2
EIF4A1	STAD	chr17	7476162	7476162	G	A	Missense_Mutation	p.M1I	2
EIF4A1	UCEC	chr17	7480414	7480414	C	T	Silent	p.D185	2
EIF4A1	PRAD	chr17	7480916	7480916	G	C	Missense_Mutation	p.L266F	2
EIF4A1	LGG	chr17	7481686	7481686	G	A	Missense_Mutation	p.R368H	2
EIF4A1	STAD	chr17	7481767	7481767	T	C	Missense_Mutation	p.I395T	2
EIF4A1	UCEC	chr17	7480777	7480777	G	A	Missense_Mutation	p.R247H	2
EIF4A1	BLCA	chr17	7478464	7478464	C	G	Missense_Mutation		2
EIF4A1	LGG	chr17	7477923	7477923	C	-	Frame_Shift_Del	p.L44fs	2
EIF4A1	UCEC	chr17	7481145	7481145	C	T	Missense_Mutation	p.H303Y	2
EIF4A1	LIHC	chr17	7480374	7480374	C	-	Splice_Site	p.S172_splice	2
EIF4A1	UCEC	chr17	7481736	7481736	C	T	Nonsense_Mutation	p.R385*	2
EIF4A1	SKCM	chr17	7476160	7476160	A	G	Missense_Mutation	p.M1V	2
EIF4A1	HNSC	chr17	7480724	7480724	G	T	Missense_Mutation	p.R229S	1
EIF4A1	MESO	chr17	7481207	7481207	C	G	Missense_Mutation	p.S323R	1
EIF4A1	LGG	chr17	7480734	7480734	C	T	Missense_Mutation	p.R233W	1
EIF4A1	STAD	chr17	7480012	7480012	T	C	Splice_Site	p.S172_splice	1
EIF4A1	CESC	chr17	7479841	7479841	G	T	Splice_Site	e5-1	1
EIF4A1	LIHC	chr17	7480708	7480708	C	-	Frame_Shift_Del	p.T224fs	1
EIF4A1	HNSC	chr17	7479955	7479955	C	T	Silent	p.H153H	1
EIF4A1	OV	chr17	7480957	7480957	A	G	Missense_Mutation	p.N280S	1
EIF4A1	LGG	chr17	7481533	7481533	T	C	Silent	p.L349L	1
EIF4A1	UCEC	chr17	7480414	7480414	C	T	Silent	p.D185D	1
EIF4A1	CESC	chr17	7480675	7480675	C	T	Missense_Mutation	p.S213L	1
EIF4A1	LUAD	chr17	7480984	7480984	C	T	Missense_Mutation	p.T289I	1
EIF4A1	HNSC	chr17	7481674	7481674	G	C	Missense_Mutation	p.G364A	1
EIF4A1	BLCA	chr17	7481193	7481193	C	A	Missense_Mutation	p.R319S	1
EIF4A1	LGG	chr17	7480800	7480800	C	T	Nonsense_Mutation	p.R255*	1
EIF4A1	COAD	chr17	7480925	7480925	C	A	Silent	p.T269T	1
EIF4A1	LUAD	chr17	7479967	7479967	T	C	Silent	p.G157G	1
EIF4A1	UCEC	chr17	7479876	7479876	T	C	Missense_Mutation	p.M127T	1
EIF4A1	CESC	chr17	7481234	7481234	G	A	Silent		1
EIF4A1	LGG	chr17	7481686	7481686	G	A	Missense_Mutation		1
EIF4A1	ESCA	chr17	7479902	7479902	G	-	Frame_Shift_Del	p.G137fs	1
EIF4A1	BLCA	chr17	7481193	7481193	C	T	Missense_Mutation		1
EIF4A1	KIRP	chr17	7478578	7478578	T	G	Missense_Mutation	p.V100G	1
EIF4A1	SKCM	chr17	7476166	7476166	G	A	Missense_Mutation	p.A3T	1
EIF4A1	CESC	chr17	7480895	7480895	G	T	Missense_Mutation		1
EIF4A1	LGG	chr17	7477923	7477923	C	-	Frame_Shift_Del		1
EIF4A1	ESCA	chr17	7477537	7477537	T	G	Missense_Mutation		1
EIF4A1	LUSC	chr17	7476179	7476179	C	T	Missense_Mutation	p.S7F	1
EIF4A1	BLCA	chr17	7480706	7480706	G	A	Silent		1
EIF4A1	KIRP	chr17	7478578	7478578	T	G	Splice_Site	p.Q115_splice	1
EIF4A1	SKCM	chr17	7480012	7480012	T	A	Splice_Site		1
EIF4A1	CESC	chr17	7477965	7477965	C	A	Silent		1
EIF4A1	LIHC	chr17	7477855	7477855	A	G	Missense_Mutation		1
EIF4A1	GBM	chr17	7480924	7480924	C	A	Missense_Mutation	p.T269N	1
EIF4A1	LUSC	chr17	7481668	7481668	G	T	Missense_Mutation	p.R362L	1
EIF4A1	OV	chr17	7422468	7422468	T	C	Silent	p.I387	1
EIF4A1	BLCA	chr17	7480991	7480991	G	T	Missense_Mutation		1
EIF4A1	KIRP	chr17	7478578	7478578	T	G	Missense_Mutation		1
EIF4A1	CESC	chr17	7480946	7480946	C	G	Silent		1
EIF4A1	LIHC	chr17	7477944	7477944	T	-	Frame_Shift_Del		1
EIF4A1	HNSC	chr17	7480724	7480724	G	T	Missense_Mutation		1
EIF4A1	LUSC	chr17	7480801	7480801	G	T	Missense_Mutation	p.R255L	1
EIF4A1	BLCA	chr17	7481736	7481736	C	G	Missense_Mutation		1
EIF4A1	CESC	chr17	7480675	7480675	C	T	Missense_Mutation		1
EIF4A1	LIHC	chr17	7477593	7477593	C	G	Silent	p.G13G	1
EIF4A1	HNSC	chr17	7480740	7480740	C	T	Missense_Mutation		1
EIF4A1	LUSC	chr17	7481183	7481183	G	C	Missense_Mutation	p.M315I	1
EIF4A1	PRAD	chr17	7481551	7481551	C	T	Silent	p.N355N	1
EIF4A1	STAD	chr17	7480012	7480012	T	C	Splice_Site	.	1
EIF4A1	CESC	chr17	7479974	7479974	G	A	Missense_Mutation		1
EIF4A1	HNSC	chr17	7479955	7479955	C	T	Silent		1
EIF4A1	LUSC	chr17	7481745	7481745	G	C	Missense_Mutation	p.E388Q	1
EIF4A1	SARC	chr17	7480414	7480414	C	T	Silent		1
EIF4A1	BLCA	chr17	7481193	7481193	C	T	Missense_Mutation	p.R319C	1
EIF4A1	LGG	chr17	7481180	7481180	T	G	Missense_Mutation	p.I314M	1
EIF4A1	STAD	chr17	7480480	7480480	C	A	Silent	p.T207T	1
EIF4A1	CESC	chr17	7481234	7481234	G	A	Splice_Site	p.L332_splice	1
EIF4A1	HNSC	chr17	7480740	7480740	C	T	Missense_Mutation	p.L235F	1
EIF4A1	MESO	chr17	7481207	7481207	C	G	Missense_Mutation		1
EIF4A1	BLCA	chr17	7480706	7480706	G	A	Silent	p.V223V	1
EIF4A1	LGG	chr17	7476160	7476160	A	C	Translation_Start_Site	p.M1L	1
EIF4A1	STAD	chr17	7468286	7468286	C	T	Translation_Start_Site		1
EIF4A1	CESC	chr17	7477965	7477965	C	A	Silent	p.I58I	1
EIF4A1	LIHC	chr17	7480379	7480379	A	-	Frame_Shift_Del	p.K174fs	1

Copy number variation (CNV) of EIF4A1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF4A1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100194	LAML	TCGA-AB-2812	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-
93408	LAML	TCGA-AB-2810	EIF4A1	chr17	7476182	+	KLF2	chr19	16437666	+
93408	LAML	TCGA-AB-2810_700GEAAXX_7	EIF4A1	chr17	7476182	+	KLF2	chr19	16437667	+
52667	GBM	TCGA-14-1034	EIF4A1	chr17	7478576	+	PHOSPHO1	chr17	47302493	-
52667	GBM	TCGA-14-1034-01A	EIF4A1	chr17	7478576	+	PHOSPHO1	chr17	47302366	-
102979	Non-Cancer	13N	FKBP14	chr7	30062280	-	EIF4A1	chr17	7478436	+
102979	LUSC	TCGA-85-A4CN-01A	RBX1	chr22	41363888	+	EIF4A1	chr17	7481545	+
102979	STAD	TCGA-BR-4253	RCC1	chr1	28832596	+	EIF4A1	chr17	7478436	+
102979	OV	TCGA-61-1736	SNHG1	chr11	62622895	-	EIF4A1	chr17	7481144	+
102979	BRCA	TCGA-E2-A14Z-01A	SULF1	chr8	70488444	+	EIF4A1	chr17	7478437	+
102979	LUSC	TCGA-85-A4CN	XPNPEP3	chr22	41363888	+	EIF4A1	chr17	7481545	+
102979	OV	TCGA-29-1766	ZNF586	chr19	58288037	+	EIF4A1	chr17	7478436	+
102982	STAD	TCGA-HU-A4HD	ZNF7	chr8	146062892	+	EIF4A1	chr17	7480373	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	EIF4A1	0.000226742528057508	0.0063
SARC	EIF4A1	0.00052526339731056	0.014
STAD	EIF4A1	0.00626129885440021	0.16
SKCM	EIF4A1	0.0294130790989434	0.74
TGCT	EIF4A1	0.0353510168360475	0.85
GBM	EIF4A1	0.0382951039242703	0.88

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THYM	EIF4A1	0.0350894467481426	1
SARC	EIF4A1	0.0105926044202986	0.35
HNSC	EIF4A1	0.0205786738201249	0.66
READ	EIF4A1	0.0386626232720135	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C4505456	HIV Coinfection	1	CTD_human