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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF4A2 (NCBI Gene ID:1974)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF4A2
	Gene ID: 1974
	Gene Symbol	EIF4A2
	Gene ID	1974
	Gene Name	eukaryotic translation initiation factor 4A2
	Synonyms	BM-010\|DDX2B\|EIF4A\|EIF4F\|eIF-4A-II\|eIF4A-II
	Cytomap	3q27.3
	Type of Gene	protein-coding
	Description	eukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2
	Modification date	20200322
	UniProtAcc	Q14240

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF4A2	GO:1900260	negative regulation of RNA-directed 5'-3' RNA polymerase activity	11922617

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF4A2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF4A2[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF4A2	eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR	31791371

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000323963	186502220	186502266	Frame-shift
ENST00000323963	186502750	186502890	Frame-shift
ENST00000323963	186504290	186504434	In-frame
ENST00000323963	186505283	186505373	In-frame
ENST00000323963	186505591	186505671	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000323963	186504290	186504434	1936	692	835	407	209	257
ENST00000323963	186505283	186505373	1936	974	1063	407	303	333

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q14240	303	333	1	407	Chain	ID=PRO_0000054938;Note=Eukaryotic initiation factor 4A-II
Q14240	209	257	1	407	Chain	ID=PRO_0000054938;Note=Eukaryotic initiation factor 4A-II
Q14240	209	257	64	235	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00541
Q14240	303	333	246	407	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00542
Q14240	209	257	246	407	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00542
Q14240	209	257	212	213	Sequence conflict	Note=LL->FA;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q14240	209	257	209	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BOR
Q14240	209	257	219	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BOR
Q14240	209	257	233	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3BOR

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	EIF4A2	1.8359785836448	0.000162905479402723

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	EIF4A2	2	1	0.00368741606299217	0.218301666666667	0.100617163882259	0.465257071140773	0.0814221626282553
ESCA	EIF4A2	2	1	0.0249526733640416	0.265996052631579	0.112888109756098	0.34533373780709	0.518620323173271

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BLCA	EIF4A2	0.061804876	0.023127758
PCPG	EIF4A2	0.188987768	0.031662627

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF4A2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	EIF4A2	PNPLA8	0.80946228	1.60E-29
THYM	Cell metabolism gene	EIF4A2	MCFD2	0.809753934	1.47E-29
THYM	Cell metabolism gene	EIF4A2	RAPGEF4	0.810674581	1.13E-29
THYM	Cell metabolism gene	EIF4A2	MUT	0.813323673	5.29E-30
THYM	Cell metabolism gene	EIF4A2	GBE1	0.816126669	2.33E-30
THYM	Cell metabolism gene	EIF4A2	AUH	0.816283426	2.23E-30
THYM	Cell metabolism gene	EIF4A2	PPP2CB	0.816531185	2.07E-30
THYM	Cell metabolism gene	EIF4A2	TNPO1	0.819988164	7.38E-31
THYM	Cell metabolism gene	EIF4A2	PIP5K1A	0.824141207	2.08E-31
THYM	Cell metabolism gene	EIF4A2	GALNT3	0.825333864	1.43E-31
THYM	Cell metabolism gene	EIF4A2	PIGK	0.829162395	4.28E-32
THYM	Cell metabolism gene	EIF4A2	COL4A3BP	0.830188618	3.08E-32
THYM	Cell metabolism gene	EIF4A2	SEC31A	0.832896654	1.28E-32
THYM	Cell metabolism gene	EIF4A2	LMAN1	0.837879202	2.43E-33
THYM	Cell metabolism gene	EIF4A2	TRMT11	0.841161738	7.91E-34
THYM	Cell metabolism gene	EIF4A2	AASDHPPT	0.84235972	5.21E-34
THYM	Cell metabolism gene	EIF4A2	SEC24D	0.845716245	1.59E-34
THYM	Cell metabolism gene	EIF4A2	PAPSS1	0.859372027	9.38E-37
THYM	Cell metabolism gene	EIF4A2	PIK3R4	0.867151236	3.93E-38
THYM	Cell metabolism gene	EIF4A2	PIK3C2A	0.872857446	3.37E-39
THYM	CGC	EIF4A2	TET2	0.80648273	3.68E-29
THYM	CGC	EIF4A2	BMPR1A	0.816220199	2.27E-30
THYM	CGC	EIF4A2	LRIG3	0.816358698	2.18E-30
THYM	CGC	EIF4A2	GOLGA5	0.818876806	1.03E-30
THYM	CGC	EIF4A2	AFF4	0.824561844	1.82E-31
THYM	CGC	EIF4A2	MAPK1	0.825183779	1.50E-31
THYM	CGC	EIF4A2	KTN1	0.826919226	8.72E-32
THYM	CGC	EIF4A2	FBXO11	0.832535165	1.44E-32
THYM	CGC	EIF4A2	SBDS	0.838249655	2.15E-33
THYM	CGC	EIF4A2	ARHGAP5	0.838805997	1.78E-33
THYM	CGC	EIF4A2	NFE2L2	0.871482285	6.15E-39
THYM	Epifactor	EIF4A2	ADNP	0.804778443	5.90E-29
THYM	Epifactor	EIF4A2	DZIP3	0.806351066	3.82E-29
THYM	Epifactor	EIF4A2	TET2	0.80648273	3.68E-29
THYM	Epifactor	EIF4A2	INO80D	0.814224188	4.07E-30
THYM	Epifactor	EIF4A2	JMJD1C	0.818358176	1.20E-30
THYM	Epifactor	EIF4A2	KDM3B	0.821761817	4.31E-31
THYM	Epifactor	EIF4A2	ZMYND11	0.843065832	4.07E-34
THYM	IUPHAR	EIF4A2	PTPRE	0.800949413	1.67E-28
THYM	IUPHAR	EIF4A2	SLC35A5	0.804768635	5.92E-29
THYM	IUPHAR	EIF4A2	SLC30A5	0.805286888	5.13E-29
THYM	IUPHAR	EIF4A2	SENP6	0.805725194	4.54E-29
THYM	IUPHAR	EIF4A2	CSNK1G3	0.806628213	3.54E-29
THYM	IUPHAR	EIF4A2	RAPGEF4	0.810674581	1.13E-29
THYM	IUPHAR	EIF4A2	ATP6V1A	0.811851591	8.08E-30
THYM	IUPHAR	EIF4A2	BMPR1A	0.816220199	2.27E-30
THYM	IUPHAR	EIF4A2	NEK4	0.817871106	1.39E-30
THYM	IUPHAR	EIF4A2	JMJD1C	0.818358176	1.20E-30
THYM	IUPHAR	EIF4A2	KDM3B	0.821761817	4.31E-31
THYM	IUPHAR	EIF4A2	PIP5K1A	0.824141207	2.08E-31
THYM	IUPHAR	EIF4A2	MAPK1	0.825183779	1.50E-31
THYM	IUPHAR	EIF4A2	PREPL	0.826916924	8.72E-32
THYM	IUPHAR	EIF4A2	SLC25A36	0.827651877	6.92E-32
THYM	IUPHAR	EIF4A2	SLC25A43	0.830099678	3.17E-32
THYM	IUPHAR	EIF4A2	AHR	0.830818101	2.51E-32
THYM	IUPHAR	EIF4A2	FBXO11	0.832535165	1.44E-32
THYM	IUPHAR	EIF4A2	ZMYND11	0.843065832	4.07E-34
THYM	IUPHAR	EIF4A2	PKN2	0.847104341	9.67E-35
THYM	IUPHAR	EIF4A2	SLC35F5	0.849270063	4.40E-35
THYM	IUPHAR	EIF4A2	PDPK1	0.853715733	8.38E-36
THYM	IUPHAR	EIF4A2	PIK3R4	0.867151236	3.93E-38
THYM	IUPHAR	EIF4A2	NFE2L2	0.871482285	6.15E-39
THYM	IUPHAR	EIF4A2	PIK3C2A	0.872857446	3.37E-39
THYM	IUPHAR	EIF4A2	MAP4K3	0.893855125	1.27E-43
THYM	Kinase	EIF4A2	CSNK1G3	0.806628213	3.54E-29
THYM	Kinase	EIF4A2	BMPR1A	0.816220199	2.27E-30
THYM	Kinase	EIF4A2	NEK4	0.817871106	1.39E-30
THYM	Kinase	EIF4A2	MAPK1	0.825183779	1.50E-31
THYM	Kinase	EIF4A2	COL4A3BP	0.830188618	3.08E-32
THYM	Kinase	EIF4A2	PKN2	0.847104341	9.67E-35
THYM	Kinase	EIF4A2	PDPK1	0.853715733	8.38E-36
THYM	Kinase	EIF4A2	PIK3R4	0.867151236	3.93E-38
THYM	Kinase	EIF4A2	MAP4K3	0.893855125	1.27E-43
THYM	TF	EIF4A2	ZBTB38	0.802737273	1.03E-28
THYM	TF	EIF4A2	NFXL1	0.80306	9.45E-29
THYM	TF	EIF4A2	ZNF304	0.803253391	8.96E-29
THYM	TF	EIF4A2	ZXDC	0.804049712	7.21E-29
THYM	TF	EIF4A2	ADNP	0.804778443	5.90E-29
THYM	TF	EIF4A2	ZNF621	0.80646734	3.70E-29
THYM	TF	EIF4A2	TET2	0.80648273	3.68E-29
THYM	TF	EIF4A2	ZNF664	0.806641092	3.52E-29
THYM	TF	EIF4A2	RREB1	0.809784992	1.46E-29
THYM	TF	EIF4A2	ZNF432	0.817093196	1.75E-30
THYM	TF	EIF4A2	ZNF440	0.818090129	1.30E-30
THYM	TF	EIF4A2	ZNF441	0.827303099	7.72E-32
THYM	TF	EIF4A2	AHR	0.830818101	2.51E-32
THYM	TF	EIF4A2	ZXDB	0.830951967	2.41E-32
THYM	TF	EIF4A2	ZBTB43	0.833638369	1.00E-32
THYM	TF	EIF4A2	MEF2A	0.836333074	4.10E-33
THYM	TF	EIF4A2	ZNF274	0.837116269	3.15E-33
THYM	TF	EIF4A2	ZNF136	0.841374773	7.34E-34
THYM	TF	EIF4A2	ZNF420	0.844850899	2.17E-34
THYM	TF	EIF4A2	ZNF354B	0.845672117	1.62E-34
THYM	TF	EIF4A2	ZNF180	0.861903857	3.41E-37
THYM	TF	EIF4A2	NFE2L2	0.871482285	6.15E-39
THYM	TF	EIF4A2	BBX	0.872221905	4.45E-39
THYM	TSG	EIF4A2	GORAB	0.802375464	1.14E-28
THYM	TSG	EIF4A2	TET2	0.80648273	3.68E-29
THYM	TSG	EIF4A2	BMPR1A	0.816220199	2.27E-30
THYM	TSG	EIF4A2	LRIG3	0.816358698	2.18E-30
THYM	TSG	EIF4A2	PPP2CB	0.816531185	2.07E-30
THYM	TSG	EIF4A2	KRIT1	0.817619053	1.50E-30
THYM	TSG	EIF4A2	KDM3B	0.821761817	4.31E-31
THYM	TSG	EIF4A2	RCHY1	0.825700172	1.28E-31
THYM	TSG	EIF4A2	AHR	0.830818101	2.51E-32
THYM	TSG	EIF4A2	DNAJB4	0.841819603	6.29E-34
THYM	TSG	EIF4A2	ZMYND11	0.843065832	4.07E-34
UCS	Cell metabolism gene	EIF4A2	PNPLA8	0.80946228	1.60E-29
UCS	Cell metabolism gene	EIF4A2	MCFD2	0.809753934	1.47E-29
UCS	Cell metabolism gene	EIF4A2	RAPGEF4	0.810674581	1.13E-29
UCS	Cell metabolism gene	EIF4A2	MUT	0.813323673	5.29E-30
UCS	Cell metabolism gene	EIF4A2	GBE1	0.816126669	2.33E-30
UCS	Cell metabolism gene	EIF4A2	AUH	0.816283426	2.23E-30
UCS	Cell metabolism gene	EIF4A2	PPP2CB	0.816531185	2.07E-30
UCS	Cell metabolism gene	EIF4A2	TNPO1	0.819988164	7.38E-31
UCS	Cell metabolism gene	EIF4A2	PIP5K1A	0.824141207	2.08E-31
UCS	Cell metabolism gene	EIF4A2	GALNT3	0.825333864	1.43E-31
UCS	Cell metabolism gene	EIF4A2	PIGK	0.829162395	4.28E-32
UCS	Cell metabolism gene	EIF4A2	COL4A3BP	0.830188618	3.08E-32
UCS	Cell metabolism gene	EIF4A2	SEC31A	0.832896654	1.28E-32
UCS	Cell metabolism gene	EIF4A2	LMAN1	0.837879202	2.43E-33
UCS	Cell metabolism gene	EIF4A2	TRMT11	0.841161738	7.91E-34
UCS	Cell metabolism gene	EIF4A2	AASDHPPT	0.84235972	5.21E-34
UCS	Cell metabolism gene	EIF4A2	SEC24D	0.845716245	1.59E-34
UCS	Cell metabolism gene	EIF4A2	PAPSS1	0.859372027	9.38E-37
UCS	Cell metabolism gene	EIF4A2	PIK3R4	0.867151236	3.93E-38
UCS	Cell metabolism gene	EIF4A2	PIK3C2A	0.872857446	3.37E-39
UCS	CGC	EIF4A2	TET2	0.80648273	3.68E-29
UCS	CGC	EIF4A2	BMPR1A	0.816220199	2.27E-30
UCS	CGC	EIF4A2	LRIG3	0.816358698	2.18E-30
UCS	CGC	EIF4A2	GOLGA5	0.818876806	1.03E-30
UCS	CGC	EIF4A2	AFF4	0.824561844	1.82E-31
UCS	CGC	EIF4A2	MAPK1	0.825183779	1.50E-31
UCS	CGC	EIF4A2	KTN1	0.826919226	8.72E-32
UCS	CGC	EIF4A2	FBXO11	0.832535165	1.44E-32
UCS	CGC	EIF4A2	SBDS	0.838249655	2.15E-33
UCS	CGC	EIF4A2	ARHGAP5	0.838805997	1.78E-33
UCS	CGC	EIF4A2	NFE2L2	0.871482285	6.15E-39
UCS	Epifactor	EIF4A2	ADNP	0.804778443	5.90E-29
UCS	Epifactor	EIF4A2	DZIP3	0.806351066	3.82E-29
UCS	Epifactor	EIF4A2	TET2	0.80648273	3.68E-29
UCS	Epifactor	EIF4A2	INO80D	0.814224188	4.07E-30
UCS	Epifactor	EIF4A2	JMJD1C	0.818358176	1.20E-30
UCS	Epifactor	EIF4A2	KDM3B	0.821761817	4.31E-31
UCS	Epifactor	EIF4A2	ZMYND11	0.843065832	4.07E-34
UCS	IUPHAR	EIF4A2	PTPRE	0.800949413	1.67E-28
UCS	IUPHAR	EIF4A2	SLC35A5	0.804768635	5.92E-29
UCS	IUPHAR	EIF4A2	SLC30A5	0.805286888	5.13E-29
UCS	IUPHAR	EIF4A2	SENP6	0.805725194	4.54E-29
UCS	IUPHAR	EIF4A2	CSNK1G3	0.806628213	3.54E-29
UCS	IUPHAR	EIF4A2	RAPGEF4	0.810674581	1.13E-29
UCS	IUPHAR	EIF4A2	ATP6V1A	0.811851591	8.08E-30
UCS	IUPHAR	EIF4A2	BMPR1A	0.816220199	2.27E-30
UCS	IUPHAR	EIF4A2	NEK4	0.817871106	1.39E-30
UCS	IUPHAR	EIF4A2	JMJD1C	0.818358176	1.20E-30
UCS	IUPHAR	EIF4A2	KDM3B	0.821761817	4.31E-31
UCS	IUPHAR	EIF4A2	PIP5K1A	0.824141207	2.08E-31
UCS	IUPHAR	EIF4A2	MAPK1	0.825183779	1.50E-31
UCS	IUPHAR	EIF4A2	PREPL	0.826916924	8.72E-32
UCS	IUPHAR	EIF4A2	SLC25A36	0.827651877	6.92E-32
UCS	IUPHAR	EIF4A2	SLC25A43	0.830099678	3.17E-32
UCS	IUPHAR	EIF4A2	AHR	0.830818101	2.51E-32
UCS	IUPHAR	EIF4A2	FBXO11	0.832535165	1.44E-32
UCS	IUPHAR	EIF4A2	ZMYND11	0.843065832	4.07E-34
UCS	IUPHAR	EIF4A2	PKN2	0.847104341	9.67E-35
UCS	IUPHAR	EIF4A2	SLC35F5	0.849270063	4.40E-35
UCS	IUPHAR	EIF4A2	PDPK1	0.853715733	8.38E-36
UCS	IUPHAR	EIF4A2	PIK3R4	0.867151236	3.93E-38
UCS	IUPHAR	EIF4A2	NFE2L2	0.871482285	6.15E-39
UCS	IUPHAR	EIF4A2	PIK3C2A	0.872857446	3.37E-39
UCS	IUPHAR	EIF4A2	MAP4K3	0.893855125	1.27E-43
UCS	Kinase	EIF4A2	CSNK1G3	0.806628213	3.54E-29
UCS	Kinase	EIF4A2	BMPR1A	0.816220199	2.27E-30
UCS	Kinase	EIF4A2	NEK4	0.817871106	1.39E-30
UCS	Kinase	EIF4A2	MAPK1	0.825183779	1.50E-31
UCS	Kinase	EIF4A2	COL4A3BP	0.830188618	3.08E-32
UCS	Kinase	EIF4A2	PKN2	0.847104341	9.67E-35
UCS	Kinase	EIF4A2	PDPK1	0.853715733	8.38E-36
UCS	Kinase	EIF4A2	PIK3R4	0.867151236	3.93E-38
UCS	Kinase	EIF4A2	MAP4K3	0.893855125	1.27E-43
UCS	TF	EIF4A2	ZBTB38	0.802737273	1.03E-28
UCS	TF	EIF4A2	NFXL1	0.80306	9.45E-29
UCS	TF	EIF4A2	ZNF304	0.803253391	8.96E-29
UCS	TF	EIF4A2	ZXDC	0.804049712	7.21E-29
UCS	TF	EIF4A2	ADNP	0.804778443	5.90E-29
UCS	TF	EIF4A2	ZNF621	0.80646734	3.70E-29
UCS	TF	EIF4A2	TET2	0.80648273	3.68E-29
UCS	TF	EIF4A2	ZNF664	0.806641092	3.52E-29
UCS	TF	EIF4A2	RREB1	0.809784992	1.46E-29
UCS	TF	EIF4A2	ZNF432	0.817093196	1.75E-30
UCS	TF	EIF4A2	ZNF440	0.818090129	1.30E-30
UCS	TF	EIF4A2	ZNF441	0.827303099	7.72E-32
UCS	TF	EIF4A2	AHR	0.830818101	2.51E-32
UCS	TF	EIF4A2	ZXDB	0.830951967	2.41E-32
UCS	TF	EIF4A2	ZBTB43	0.833638369	1.00E-32
UCS	TF	EIF4A2	MEF2A	0.836333074	4.10E-33
UCS	TF	EIF4A2	ZNF274	0.837116269	3.15E-33
UCS	TF	EIF4A2	ZNF136	0.841374773	7.34E-34
UCS	TF	EIF4A2	ZNF420	0.844850899	2.17E-34
UCS	TF	EIF4A2	ZNF354B	0.845672117	1.62E-34
UCS	TF	EIF4A2	ZNF180	0.861903857	3.41E-37
UCS	TF	EIF4A2	NFE2L2	0.871482285	6.15E-39
UCS	TF	EIF4A2	BBX	0.872221905	4.45E-39
UCS	TSG	EIF4A2	GORAB	0.802375464	1.14E-28
UCS	TSG	EIF4A2	TET2	0.80648273	3.68E-29
UCS	TSG	EIF4A2	BMPR1A	0.816220199	2.27E-30
UCS	TSG	EIF4A2	LRIG3	0.816358698	2.18E-30
UCS	TSG	EIF4A2	PPP2CB	0.816531185	2.07E-30
UCS	TSG	EIF4A2	KRIT1	0.817619053	1.50E-30
UCS	TSG	EIF4A2	KDM3B	0.821761817	4.31E-31
UCS	TSG	EIF4A2	RCHY1	0.825700172	1.28E-31
UCS	TSG	EIF4A2	AHR	0.830818101	2.51E-32
UCS	TSG	EIF4A2	DNAJB4	0.841819603	6.29E-34
UCS	TSG	EIF4A2	ZMYND11	0.843065832	4.07E-34
UVM	Cell metabolism gene	EIF4A2	TOMM70A	0.834731324	6.60E-22
UVM	Cell metabolism gene	EIF4A2	PIK3R4	0.839312923	2.42E-22
UVM	CGC	EIF4A2	MLF1	0.80056581	5.03E-19
UVM	CGC	EIF4A2	RAF1	0.853566058	8.58E-24
UVM	Epifactor	EIF4A2	SATB1	0.802201233	3.77E-19
UVM	Epifactor	EIF4A2	RYBP	0.804155587	2.66E-19
UVM	Epifactor	EIF4A2	MSL2	0.808143161	1.30E-19
UVM	Epifactor	EIF4A2	UBE2E1	0.808602382	1.19E-19
UVM	Epifactor	EIF4A2	SETMAR	0.825122478	4.93E-21
UVM	Epifactor	EIF4A2	SETD5	0.835890194	5.13E-22
UVM	IUPHAR	EIF4A2	NEK11	0.815251495	3.43E-20
UVM	IUPHAR	EIF4A2	ATP2C1	0.822037351	9.15E-21
UVM	IUPHAR	EIF4A2	PIK3R4	0.839312923	2.42E-22
UVM	IUPHAR	EIF4A2	RAF1	0.853566058	8.58E-24
UVM	Kinase	EIF4A2	NEK11	0.815251495	3.43E-20
UVM	Kinase	EIF4A2	PIK3R4	0.839312923	2.42E-22
UVM	Kinase	EIF4A2	RAF1	0.853566058	8.58E-24
UVM	TF	EIF4A2	SATB1	0.802201233	3.77E-19
UVM	TF	EIF4A2	ZNF667	0.811488179	6.98E-20
UVM	TF	EIF4A2	ZNF391	0.816181771	2.87E-20
UVM	TF	EIF4A2	ZNF415	0.82084525	1.16E-20
UVM	TF	EIF4A2	ZNF197	0.838620252	2.82E-22
UVM	TSG	EIF4A2	WDR48	0.814280681	4.13E-20
UVM	TSG	EIF4A2	MTUS1	0.859146237	2.11E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
HNSC	EIF4A2	EIF1	-4.13399438210909	0.000228392819053625
LUAD	EIF4A2	PDCD4	1.15931823826993	0.00162636946590219
BRCA	EIF4A2	EIF4G2	1.33801911881742	0.0018433651637361
BRCA	EIF4A2	EIF4G3	1.34206807761848	0.00309822300858815
CHOL	EIF4A2	PABPC1	-4.56272528815353	0.00390625
STAD	EIF4A2	EIF4G2	-4.30902559301167	0.0050255935639143
KICH	EIF4A2	EIF4G1	-1.46656081150743	0.00612920522689819
PRAD	EIF4A2	EIF1	1.32822648991353	0.00674237731133815
BLCA	EIF4A2	PABPC1	1.31485302792746	0.0180816650390625
READ	EIF4A2	PDCD4	-3.13328676129312	0.03125
ESCA	EIF4A2	EIF4A1	-1.24538073199285	0.0419921875
HNSC	EIF4A2	PDCD4	-6.91824922290957	1.13186615635641e-09
THCA	EIF4A2	EIF4G3	-1.00361616225016	1.40000643717562e-05
LUAD	EIF4A2	EIF4G3	-4.21879885884405	2.22325471114907e-07
BRCA	EIF4A2	EIF4B	-2.16032742029696	2.35556737304054e-22
LIHC	EIF4A2	PABPC1	-1.72076961362188	2.98009622125841e-06
LUSC	EIF4A2	EIF4G3	-4.43634473815109	3.64325144746635e-05
KICH	EIF4A2	EIF4E	1.61675210562671	6.55651092529297e-06
KIRC	EIF4A2	EIF4B	1.14997140510474	7.59366366705366e-09
KICH	EIF4A2	EIF4A1	1.14485583309571	8.16583633422851e-06
PRAD	EIF4A2	PABPC1	-2.10200318363476	8.55379952759014e-07
COAD	EIF4A2	PDCD4	-5.14091568352005	8.94069671630861e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF4A2

EIF4G1, EIF3A, PDCD4, P4HB, EIF3L, EIF3D, EIF3H, MYO1B, EIF3M, PABPC1, EIF3K, EIF4G3, DDX3X, EIF4G2, EIF4E, CD2BP2, SPAG9, AKAP17A, ATRX, VAC14, ALPI, PTPRS, RPS29, TPM3, CMBL, EIF3F, RPAP2, CD4, Eif3a, NEK2, TK1, PFDN1, EIF4A1, DDX39B, BRCA1, ECT2, VCP, CD81, BAG3, EIF4A2, MDFI, IPO11, DPPA4, TRIM36, TRIM39, SSX2IP, PIH1D2, SLC16A9, HNRNPA1, HSPB1, UNK, AIMP1, CETN2, RPSA, EIF4A3, LAGE3, HSPB2, GOLGA2, CRY1, CRY2, MCM2, CDC5L, DUSP28, CYLD, TRIM25, MCPH1, FBXO7, TMPO, HEXIM1, RUNX1, SUZ12, NR2C2, AGRN, APEX1, ITFG1, TRIM28, PPIA, TEX101, ZNF620, LINC01554, SH3GL3, MN1, CDCA5, ATXN2, EIF3B, EIF3C, EIF3E, EIF3G, EIF3I, EIF4B, PABPC4, PRRC2A, PRRC2B, PRRC2C, TDRD3, TOP3B, UPF1, USP10, IBTK, YTHDF2, SMG1, CIT, ANLN, CHMP4C, KIF14, KIF20A, KIF23, PRC1, PRNP, SUMO2, NUPR1, EIF4EBP2, EIF4ENIF1, EIF4EBP1, ANGEL1, SPOP, DDRGK1, TUBB, TRIM37, SPRTN, CCNF, HECTD1, OPTN,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF4A2	LUAD	chr3	186505350	186505350	G	T	Missense_Mutation	p.V326F	7
EIF4A2	BRCA	chr3	186502374	186502374	G	A	Missense_Mutation	p.D33N	4
EIF4A2	BRCA	chr3	186505647	186505647	C	G	Missense_Mutation	p.T352S	3
EIF4A2	LIHC	chr3	186504304	186504304	C	T	Missense_Mutation	p.S214F	3
EIF4A2	UCEC	chr3	186505598	186505598	G	T	Missense_Mutation	p.G336W	3
EIF4A2	KIRP	chr3	186503770	186503770	G	T	Missense_Mutation	p.Q149H	3
EIF4A2	PAAD	chr3	186505616	186505616	G	A	Missense_Mutation	p.V342M	3
EIF4A2	BRCA	chr3	186503952	186503952	G	A	Splice_Site	e6-1	3
EIF4A2	ESCA	chr3	186504993	186504993	G	T	Missense_Mutation	p.R283S	3
EIF4A2	BRCA	chr3	186504030	186504030	G	C	Missense_Mutation	p.E199Q	3
EIF4A2	BRCA	chr3	186504350	186504351	GA	-	Frame_Shift_Del	p.D231fs	3
EIF4A2	LUAD	chr3	186502264	186502264	G	C	Missense_Mutation	p.E25Q	2
EIF4A2	SARC	chr3	186506919	186506919	G	A	Missense_Mutation		2
EIF4A2	SKCM	chr3	186505599	186505599	G	A	Missense_Mutation	p.G336E	2
EIF4A2	CESC	chr3	186503991	186503991	G	T	Missense_Mutation		2
EIF4A2	KIRC	chr3	186504360	186504360	A	C	Missense_Mutation	p.I233L	2
EIF4A2	BLCA	chr3	186504931	186504932	AC	-	Frame_Shift_Del	p.T263fs	2
EIF4A2	KIRC	chr3	186505363	186505363	C	T	Missense_Mutation	p.T330I	2
EIF4A2	LIHC	chr3	186503676	186503676	A	-	Frame_Shift_Del	p.Q118fs	2
EIF4A2	CESC	chr3	186504951	186504951	G	A	Silent		2
EIF4A2	UCEC	chr3	186503752	186503752	T	C	Nonstop_Mutation	p.*98R	2
EIF4A2	CESC	chr3	186505011	186505011	G	C	Silent		2
EIF4A2	UCEC	chr3	186503753	186503753	G	T	Nonsense_Mutation	p.E144*	2
EIF4A2	STAD	chr3	186502807	186502807	A	G	Missense_Mutation	p.I89V	2
EIF4A2	CESC	chr3	186502437	186502437	G	C	Missense_Mutation		2
EIF4A2	UCEC	chr3	186504412	186504412	T	G	Missense_Mutation	p.F250C	2
EIF4A2	BRCA	chr3	186507018	186507018	C	T	Missense_Mutation	p.T395I	2
EIF4A2	STAD	chr3	186504931	186504931	A	G	Missense_Mutation	p.T263A	2
EIF4A2	CESC	chr3	186503748	186503748	G	C	Missense_Mutation		2
EIF4A2	BLCA	chr3	186501413	186501413	C	T	Missense_Mutation	p.S5F	2
EIF4A2	PAAD	chr3	186505616	186505616	G	A	Missense_Mutation		2
EIF4A2	UCEC	chr3	186502819	186502819	C	T	Nonsense_Mutation	p.Q93*	2
EIF4A2	UCEC	chr3	186504995	186504995	G	A	Missense_Mutation	p.R284H	2
EIF4A2	SKCM	chr3	186502263	186502263	C	T	Silent	p.I24I	2
EIF4A2	STAD	chr3	186505288	186505288	G	A	Missense_Mutation	p.G305D	2
EIF4A2	ESCA	chr3	186507053	186507053	A	G	Missense_Mutation		2
EIF4A2	UCEC	chr3	186505341	186505341	T	C	Missense_Mutation	p.S323P	2
EIF4A2	LGG	chr3	186501406	186501406	G	T	Missense_Mutation	p.G3C	2
EIF4A2	STAD	chr3	186504980	186504980	T	C	Missense_Mutation	p.F279S	2
EIF4A2	PAAD	chr3	186503747	186503747	C	A	Silent	p.R142R	2
EIF4A2	UCEC	chr3	186505363	186505368	CTGACT	-	In_Frame_Del	p.TDL330in_frame_delM	2
EIF4A2	SKCM	chr3	186504350	186504350	G	A	Missense_Mutation	p.M229I	2
EIF4A2	LUAD	chr3	186503788	186503788	T	C	Silent	p.I155I	2
EIF4A2	STAD	chr3	186504345	186504345	T	A	Missense_Mutation	p.F228I	2
EIF4A2	BLCA	chr3	186503747	186503747	C	A	Silent		2
EIF4A2	BLCA	chr3	186505329	186505329	T	G	Missense_Mutation	p.F319V	2
EIF4A2	SARC	chr3	186504939	186504939	T	G	Missense_Mutation		2
EIF4A2	UCEC	chr3	186506991	186506991	G	A	Missense_Mutation	p.R386H	2
EIF4A2	LIHC	chr3	186504304	186504304	C	T	Missense_Mutation		2
EIF4A2	SKCM	chr3	186502861	186502861	T	C	Silent	p.L107L	2
EIF4A2	STAD	chr3	186503790	186503790	T	A	Missense_Mutation	p.V156D	2
EIF4A2	ESCA	chr3	186507053	186507053	A	G	Missense_Mutation	p.I407V	2
EIF4A2	HNSC	chr3	186504984	186504984	C	G	Silent	p.L280L	2
EIF4A2	SARC	chr3	186502839	186502839	C	T	Silent		2
EIF4A2	LIHC	chr3	186502251	186502271	CGATGGTGTCATCGAGGTAAG	-	Splice_Site		1
EIF4A2	SKCM	chr3	186501362	186501362	C	T	Splice_Site	.	1
EIF4A2	BLCA	chr3	186507037	186507037	G	A	Missense_Mutation		1
EIF4A2	BLCA	chr3	186502252	186502252	G	A	Missense_Mutation		1
EIF4A2	CHOL	chr3	186504030	186504030	G	T	Nonsense_Mutation	p.E199X	1
EIF4A2	THYM	chr3	186501279	186501279	C	T	Missense_Mutation		1
EIF4A2	BLCA	chr3	186502252	186502252	G	A	Missense_Mutation	p.D21N	1
EIF4A2	ESCA	chr3	186503674	186503674	C	T	Silent	p.I117I	1
EIF4A2	KIRC	chr3	186505633	186505633	T	G	Missense_Mutation	p.N347K	1
EIF4A2	LIHC	chr3	186502787	186502787	G	C	Missense_Mutation	p.G82A	1
EIF4A2	BLCA	chr3	186501413	186501413	C	T	Missense_Mutation		1
EIF4A2	BLCA	chr3	186502264	186502264	G	A	Missense_Mutation		1
EIF4A2	COAD	chr3	186502466	186502468	TAT	-	In_Frame_Del	p.63_64del	1
EIF4A2	LUAD	chr3	186504304	186504304	C	G	Missense_Mutation	p.S214C	1
EIF4A2	THYM	chr3	186504396	186504396	G	T	Nonsense_Mutation	p.E245X	1
EIF4A2	BLCA	chr3	186505012	186505012	A	G	Missense_Mutation	p.T290A	1
EIF4A2	HNSC	chr3	186501414	186501414	C	A	Silent		1
EIF4A2	SARC	chr3	186504939	186504939	T	G	Missense_Mutation	p.C265W	1
EIF4A2	SKCM	chr3	186504002	186504002	G	A	Silent	p.L189L	1
EIF4A2	BLCA	chr3	186504931	186504932	AC	-	Frame_Shift_Del		1
EIF4A2	CESC	chr3	186502788	186502798	CAAGACAGCCA	-	Frame_Shift_Del		1
EIF4A2	BLCA	chr3	186502365	186502365	G	A	Missense_Mutation		1
EIF4A2	DLBC	chr3	186502355	186502355	C	G	Missense_Mutation	p.S26R	1
EIF4A2	LUSC	chr3	186503789	186503789	G	A	Missense_Mutation	p.V156I	1
EIF4A2	HNSC	chr3	186502849	186502849	C	A	Missense_Mutation		1
EIF4A2	SARC	chr3	186502839	186502839	C	T	Silent	p.F99F	1
EIF4A2	SKCM	chr3	186504015	186504015	A	-	Frame_Shift_Del	p.K194fs	1
EIF4A2	BLCA	chr3	186502795	186502795	G	T	Missense_Mutation		1
EIF4A2	BLCA	chr3	186505012	186505012	A	G	Missense_Mutation		1
EIF4A2	DLBC	chr3	186502430	186502430	C	T	Silent	p.Y51Y	1
EIF4A2	LUSC	chr3	186504960	186504960	C	A	Silent	p.T272T	1
EIF4A2	UCEC	chr3	186503752	186503752	T	C	Silent	p.N143N	1
EIF4A2	BLCA	chr3	186503971	186503974	TGTT	-	Frame_Shift_Del	p.MF179fs	1
EIF4A2	HNSC	chr3	186504984	186504984	C	G	Silent		1
EIF4A2	KIRP	chr3	186505347	186505348	-	A	Frame_Shift_Ins	p.R325fs	1
EIF4A2	SARC	chr3	186502839	186502839	C	T	Silent	p.F100	1
EIF4A2	LIHC	chr3	186504339	186504339	A	-	Frame_Shift_Del	p.K227fs	1
EIF4A2	SKCM	chr3	186507006	186507007	TC	-	Frame_Shift_Del	p.F391fs	1
EIF4A2	BLCA	chr3	186503736	186503736	G	A	Missense_Mutation		1
EIF4A2	BLCA	chr3	186506969	186506969	G	T	Nonsense_Mutation	p.E379*	1
EIF4A2	ESCA	chr3	186507053	186507053	A	G	Missense_Mutation	p.I408V	1
EIF4A2	OV	chr3	187984101	187984101	G	T	Missense_Mutation		1
EIF4A2	UCEC	chr3	186504998	186504998	A	G	Missense_Mutation	p.K285R	1
EIF4A2	BLCA	chr3	186503971	186503974	TGTT	-	Frame_Shift_Del	p.M179fs	1
EIF4A2	HNSC	chr3	186501400	186501421	ATGTCTGGTGGCTCCGCGGATT	-	Frame_Shift_Del		1
EIF4A2	KIRP	chr3	186504962	186504962	T	C	Missense_Mutation	p.I273T	1
EIF4A2	SARC	chr3	186504939	186504939	T	G	Missense_Mutation	p.C266W	1
EIF4A2	LUAD	chr3	186505046	186505046	C	T	Missense_Mutation	p.S301F	1
EIF4A2	BLCA	chr3	186502228	186502228	G	C	Missense_Mutation		1
EIF4A2	BLCA	chr3	186507037	186507037	G	A	Missense_Mutation	p.M401I	1
EIF4A2	ESCA	chr3	186503674	186503674	C	T	Missense_Mutation	p.P72S	1
EIF4A2	OV	chr3	187988016	187988016	G	C	Missense_Mutation		1
EIF4A2	UCEC	chr3	186505363	186505368	CTGACT	-	In_Frame_Del	p.330_332TDL>M	1
EIF4A2	HNSC	chr3	186504028	186504028	A	T	Missense_Mutation		1
EIF4A2	SARC	chr3	186506919	186506919	G	A	Missense_Mutation	p.G363D	1
EIF4A2	BLCA	chr3	186501375	186501375	C	T	Missense_Mutation		1
EIF4A2	ESCA	chr3	186504993	186504993	G	T	Missense_Mutation	p.R284S	1
EIF4A2	HNSC	chr3	186505353	186505353	C	G	Missense_Mutation		1
EIF4A2	KIRP	chr3	186503770	186503770	G	T	Missense_Mutation		1
EIF4A2	LUAD	chr3	186506920	186506920	C	T	Silent	p.G362G	1
EIF4A2	BLCA	chr3	186503971	186503974	TGTT	-	Frame_Shift_Del		1
EIF4A2	CESC	chr3	186502834	186502834	G	T	Nonsense_Mutation		1
EIF4A2	BLCA	chr3	186502795	186502795	G	T	Missense_Mutation	p.A85S	1
EIF4A2	HNSC	chr3	186505353	186505353	C	G	Missense_Mutation	p.L327V	1
EIF4A2	SKCM	chr3	186504015	186504015	A	-	Frame_Shift_Del	p.F193fs	1
EIF4A2	LUAD	chr3	186502391	186502391	G	T	Missense_Mutation	p.M38I	1
EIF4A2	BLCA	chr3	186505329	186505329	T	G	Missense_Mutation		1
EIF4A2	CESC	chr3	186502834	186502834	G	T	Nonsense_Mutation	p.E99*	1
EIF4A2	BLCA	chr3	186503736	186503736	G	A	Missense_Mutation	p.G138E	1
EIF4A2	LGG	chr3	186501406	186501406	G	T	Missense_Mutation		1
EIF4A2	CESC	chr3	186502437	186502437	G	C	Missense_Mutation	p.E55Q	1
EIF4A2	ESCA	chr3	186506930	186506930	C	A	Silent	p.R366R	1
EIF4A2	HNSC	chr3	186504028	186504028	A	T	Missense_Mutation	p.Y198F	1
EIF4A2	BLCA	chr3	186503753	186503753	G	A	Missense_Mutation		1
EIF4A2	CESC	chr3	186505011	186505011	G	C	Silent	p.L290	1
EIF4A2	LUAD	chr3	186501404	186501404	C	T	Missense_Mutation	p.S2F	1
EIF4A2	BLCA	chr3	186503753	186503753	G	A	Missense_Mutation	p.E144K	1

Copy number variation (CNV) of EIF4A2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF4A2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99660	N/A	BF840289	ACTR2	chr2	65497286	-	EIF4A2	chr3	186506064	+
99660	N/A	AI810008	ATP6V1C2	chr2	10923658	+	EIF4A2	chr3	186506831	-
99660	N/A	FN161688	C12orf42	chr12	103745137	-	EIF4A2	chr3	186507301	-
99660	THCA	TCGA-DJ-A3V6-01A	CTSB	chr8	11701564	-	EIF4A2	chr3	186501336	+
99660	N/A	BF987336	DLG5	chr10	79584177	+	EIF4A2	chr3	186502299	-
87203	STAD	TCGA-BR-8284-01A	EIF4A2	chr3	186501428	+	AARS	chr16	70316687	-
103286	GBM	TCGA-06-0238-01A	EIF4A2	chr3	186502266	+	ACTR3	chr2	114691856	+
87811	N/A	EY123259	EIF4A2	chr3	186507553	+	ATG13	chr11	46650505	-
89533	OV	TCGA-13-A5FT-01A	EIF4A2	chr3	186502266	+	DNAJB11	chr3	186314843	+
89533	OV	TCGA-13-A5FT-01A	EIF4A2	chr3	186502302	+	DNAJB11	chr3	186314843	+
99660	N/A	AA523672	EIF4A2	chr3	186507529	-	EIF4A2	chr3	186507500	+
99660	N/A	AA730953	EIF4A2	chr3	186507443	+	EIF4A2	chr3	186507476	-
99660	N/A	AW840050	EIF4A2	chr3	186505963	+	EIF4A2	chr3	186505704	-
99660	N/A	BG979271	EIF4A2	chr3	186506486	-	EIF4A2	chr3	186506836	+
95355	BRCA	TCGA-AC-A2BK-01A	EIF4A2	chr3	186502414	+	FAM149B1	chr10	74959593	+
86127	N/A	BM773122	EIF4A2	chr3	186506183	+	FUS	chr16	31202784	+
89879	STAD	TCGA-HU-A4GT-01A	EIF4A2	chr3	186505373	+	HIF1A	chr14	62213652	+
25949	LUSC	TCGA-34-5232	EIF4A2	chr3	186502017	+	IGKC	chr2	89161431	-
98603	LIHC	TCGA-BC-A10Y-01A	EIF4A2	chr3	186504062	+	KNG1	chr3	186461494	+
103085	N/A	DA558800	EIF4A2	chr3	186505539	+	LMNA	chr1	156084526	+
94565	STAD	TCGA-BR-8284-01A	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+
93298	N/A	BM834299	EIF4A2	chr3	186501436	+	PPDPF	chr20	62153365	+
88868	STAD	TCGA-CD-A4MH-01A	EIF4A2	chr3	186505671	+	RBMX2	chrX	129545322	+
97411	N/A	BF338517	EIF4A2	chr3	186507655	+	RFC4	chr3	186507813	+
25949	N/A	BF526915	EIF4A2	chr3	186507686	+	RP11-114G22.1	chr12	23061142	+
101048	STAD	TCGA-CD-8530-01A	EIF4A2	chr3	186505053	+	SMAD6	chr15	67004006	+
84147	STAD	TCGA-CD-A486-01A	EIF4A2	chr3	186504062	+	SMG8	chr17	57292166	+
25949	N/A	AW022230	EIF4A2	chr3	186507686	+	SPANXA2-OT1	chrX	140593415	-
92840	N/A	DA027118	EIF4A2	chr3	186503752	+	TGFBI	chr5	135364680	+
98632	STAD	TCGA-EQ-8122-01A	EIF4A2	chr3	186505373	+	VIM	chr10	17278293	+
99660	LUSC	TCGA-21-1075-01A	FGFR2	chr10	123243212	-	EIF4A2	chr3	186504916	+
99660	OV	TCGA-61-1900	HSP90AA1	chr14	102549370	-	EIF4A2	chr3	186504915	+
99660	N/A	BQ355782	KIAA1217	chr10	24833139	-	EIF4A2	chr3	186507348	+
99660	N/A	CB048230	PTEN	chr10	89726688	+	EIF4A2	chr3	186507686	-
99660	Non-Cancer	TCGA-A7-A0D9-11A	SORT1	chr1	109859471	-	EIF4A2	chr3	186504915	+
99660	OV	TCGA-25-1312-01A	ST6GAL1	chr3	186769134	+	EIF4A2	chr3	186505284	+
99669	STAD	TCGA-HU-A4GN-01A	XPO1	chr2	61722590	-	EIF4A2	chr3	186504916	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	EIF4A2	0.00156907357154133	0.042
SARC	EIF4A2	0.00451761087740595	0.12
PCPG	EIF4A2	0.0354082367840579	0.89
HNSC	EIF4A2	1.30974888314952e-08	3.7e-07

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	EIF4A2	0.00223077027635097	0.069
LGG	EIF4A2	0.0366293784677008	1
BRCA	EIF4A2	0.0131647528269764	0.38
ESCA	EIF4A2	0.00735827091231367	0.22
THYM	EIF4A2	0.000697952640371028	0.023
SARC	EIF4A2	0.00113644982641427	0.036

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0001969	Alcoholic Intoxication	1	PSYGENET
C0394996	Acute alcoholic intoxication	1	PSYGENET