|
Translation Factor: EIF4B (NCBI Gene ID:1975) |
|
Gene Summary |
Gene Information | Gene Name: EIF4B | Gene ID: 1975 | Gene Symbol | EIF4B | Gene ID | 1975 |
Gene Name | eukaryotic translation initiation factor 4B | |
Synonyms | EIF-4B|PRO1843 | |
Cytomap | 12q13.13 | |
Type of Gene | protein-coding | |
Description | eukaryotic translation initiation factor 4B | |
Modification date | 20200313 | |
UniProtAcc | P23588 |
Child GO biological process term(s) under GO:0006412 |
GO ID | GO term |
GO:0006417 | Regulation of translation |
GO:0008135 | Translation factor activity, RNA binding |
GO:0002181 | Cytoplasmic translation |
GO:0006413 | Translational initiation |
GO:0006412 | Translation |
Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Inferred gene age of translation factor. |
Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
EIF4B | (733 - 1119.25] |
Top |
|
We searched PubMed using 'EIF4B[title] AND translation [title] AND human.' |
Gene | Title | PMID |
EIF4B | eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology | 28874824 |
Top |
|
Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
ENST00000262056 | 53413693 | 53413810 | In-frame |
ENST00000262056 | 53416276 | 53416411 | In-frame |
ENST00000262056 | 53421565 | 53421703 | In-frame |
ENST00000262056 | 53431192 | 53431406 | Frame-shift |
ENST00000262056 | 53433021 | 53433127 | Frame-shift |
ENST00000262056 | 53433413 | 53433486 | Frame-shift |
Exon skipping position in the amino acid sequence. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
ENST00000262056 | 53413693 | 53413810 | 4165 | 687 | 803 | 611 | 120 | 159 |
ENST00000262056 | 53416276 | 53416411 | 4165 | 859 | 993 | 611 | 177 | 222 |
ENST00000262056 | 53421565 | 53421703 | 4165 | 994 | 1131 | 611 | 222 | 268 |
Potentially (partially) lost protein functional features of UniProt. |
UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
P23588 | 177 | 222 | 1 | 611 | Chain | ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B |
P23588 | 120 | 159 | 1 | 611 | Chain | ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B |
P23588 | 222 | 268 | 1 | 611 | Chain | ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B |
P23588 | 120 | 159 | 96 | 173 | Domain | Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 |
P23588 | 177 | 222 | 164 | 331 | Compositional bias | Note=Arg-rich |
P23588 | 222 | 268 | 164 | 331 | Compositional bias | Note=Arg-rich |
P23588 | 177 | 222 | 169 | 325 | Compositional bias | Note=Asp-rich |
P23588 | 222 | 268 | 169 | 325 | Compositional bias | Note=Asp-rich |
P23588 | 177 | 222 | 192 | 192 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 |
P23588 | 177 | 222 | 207 | 207 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
P23588 | 177 | 222 | 219 | 219 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
P23588 | 120 | 159 | 121 | 159 | Alternative sequence | ID=VSP_057351;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
P23588 | 177 | 222 | 203 | 203 | Natural variant | ID=VAR_064710;Note=Found in a renal cell carcinoma case%3B somatic mutation. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=PMID:21248752 |
P23588 | 222 | 268 | 246 | 246 | Sequence conflict | Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P23588 | 120 | 159 | 121 | 125 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8 |
P23588 | 120 | 159 | 130 | 133 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J76 |
P23588 | 120 | 159 | 140 | 146 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8 |
P23588 | 120 | 159 | 147 | 154 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8 |
P23588 | 120 | 159 | 155 | 157 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8 |
Top |
|
Gene expression level across TCGA pancancer |
Gene expression level across GTEx pantissue |
Expression level of gene isoforms across TCGA pancancer |
Expression level of gene isoforms across GTEx pantissue |
Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
Cancer type | Translation factor | FC | adj.pval |
BRCA | EIF4B | -2.16032742029696 | 2.35556737304054e-22 |
KIRC | EIF4B | 1.14997140510474 | 7.59366366705366e-09 |
Top |
|
Translation factor expression regulation through miRNA binding |
Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
GBM | EIF4B | hsa-miR-185-5p | 94 | 1 | 0.0166666666666667 |
UCEC | EIF4B | hsa-miR-185-5p | 94 | -0.344843391902215 | 0.0464108520833579 |
Translation factor expression regulation through methylation in the promoter of Translation factor |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
LUSC | EIF4B | 2 | 1 | 0.0488464358388931 | 0.213660170212766 | 0.167375911949686 | 0.100389310731222 | 0.043691412296842 |
SARC | EIF4B | 2 | 1 | 0.0392624624230068 | 0.224499581151832 | 0.166057435897436 | 0.00809409183848272 | 0.097534989945601 |
Translation factor expression regulation through copy number variation of Translation factor |
Cancer type | Gene | Coefficient | Pvalue |
LIHC | EIF4B | 0.046786327 | 0.018955082 |
CHOL | EIF4B | 0.044699099 | 0.048740155 |
Top |
|
Strongly correlated genes belong to cellular important gene groups with EIF4B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
Top |
|
Protein 3D structure Visit iCn3D. |
Top |
|
Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
* Edge colors based on TCGA cancer types. |
* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
KIRC | EIF4B | RPS6 | -3.4556058277803 | 0.0001224322154943 |
LUAD | EIF4B | EIF4A2 | 1.8359785836448 | 0.000162905479402723 |
PRAD | EIF4B | RPS6KB1 | 1.25047501981198 | 0.000199084406212897 |
PRAD | EIF4B | EIF3A | 1.13680328391952 | 0.000363360004697762 |
BRCA | EIF4B | EIF5 | -1.16704316213885 | 0.00107943958337404 |
COAD | EIF4B | RPS6KB1 | -1.1133069567678 | 0.00144392251968384 |
THCA | EIF4B | RPS6 | 1.46346143665389 | 0.00305071956645465 |
CHOL | EIF4B | PABPC1 | -4.56272528815353 | 0.00390625 |
KIRP | EIF4B | EIF3G | -2.4178322962129 | 0.00471024587750435 |
BLCA | EIF4B | EIF3A | -4.45104058307747 | 0.00532913208007812 |
KICH | EIF4B | EIF4G1 | -1.46656081150743 | 0.00612920522689819 |
KIRP | EIF4B | RPS6 | -1.15360907834159 | 0.0111397774890065 |
COAD | EIF4B | RPS6 | 1.03379589520851 | 0.011966735124588 |
BLCA | EIF4B | RPS6 | -1.76940777579938 | 0.012359619140625 |
BLCA | EIF4B | PABPC1 | 1.31485302792746 | 0.0180816650390625 |
HNSC | EIF4B | RPS6KB1 | -1.27996809705029 | 0.0301271170746986 |
UCEC | EIF4B | EIF3G | -3.35078334696571 | 0.03125 |
BLCA | EIF4B | EIF3G | -3.07707559649091 | 0.0323410034179688 |
ESCA | EIF4B | EIF4A1 | -1.24538073199285 | 0.0419921875 |
BRCA | EIF4B | EIF3G | 1.87948385011271 | 1.9107949115022e-06 |
KIRP | EIF4B | RPS6KB1 | -1.46465474284348 | 2.00420618057251e-06 |
LIHC | EIF4B | PABPC1 | -1.72076961362188 | 2.98009622125841e-06 |
LIHC | EIF4B | EIF5 | -2.12060405382854 | 4.66164898670786e-08 |
KICH | EIF4B | EIF4E | 1.61675210562671 | 6.55651092529297e-06 |
BRCA | EIF4B | EIF3A | -1.218215573148 | 7.39403582934137e-06 |
KICH | EIF4B | EIF4A1 | 1.14485583309571 | 8.16583633422851e-06 |
PRAD | EIF4B | PABPC1 | -2.10200318363476 | 8.55379952759014e-07 |
Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
PPI interactors with EIF4B |
PABPC1, EIF3B, EIF4B, EIF3A, EIF3F, USP11, USP7, ALK, KBTBD7, AGO3, AGO4, Ccdc15, ELAVL1, ARRB1, ARRB2, TSG101, TERF1, TINF2, ACD, POT1, CUL3, EIF4A1, EIF4G1, RPL29, PHAX, EIF4G2, MYH9, CSTF2, NUP107, NUP153, SLC4A1AP, CCT6B, POLR1C, MAGOH, EIF4A3, SMURF1, YWHAE, CSNK2A1, PAN2, FBXO6, PARK2, Stk11, CTNNA1, CUL4B, NARS, OSBP, SAMHD1, SEC23A, XRCC5, PRMT3, SF1, XPO7, ASB2, ZBTB1, SMAD3, FBXW11, MAEL, CCT6A, CFL1, CTPS1, DDX39A, DOHH, LASP1, GSPT1, HSPB1, IMPDH2, KHSRP, SFN, YWHAQ, YWHAZ, NTRK1, gag, SRPK2, XPO1, HIST1H3E, AHSA1, CDC25B, ERCC6L, Crebbp, Smad3, Pten, Wiz, Naa10, Tmed10, Ttll12, GAN, RHOU, RC3H1, CDH1, EGFR, CYLD, TRIM25, G3BP1, YAP1, OTUD6B, GRHPR, UBE2M, EFTUD2, TNIP2, RNF31, SNAI1, RECQL4, GPC1, KCNJ2, ZFP36L2, METTL3, METTL14, KIAA1429, ALB, ANKRD53, ARPC5, BAZ2A, C14orf166, RTCB, CDON, DDX1, DDX3X, DDX3Y, DENND1C, DLEC1, DSG4, EIF3D, EIF3E, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, FAM98A, FEZF2, FGF11, HIST1H4A, HNRNPA1, HNRNPD, HNRNPU, HSPA1A, HSPA6, HSPA8, MRPS23, PRMT1, RBM12B, RBMX, RPL14, RPL18, RPL22, RPL23A, RPL24, RPL31, RPL9, RPS10, RPS11, RPS12, RPS13, RPS14, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS20, RPS23, RPS24, RPS25, RPS26, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS7, RPS8, RPS9, RPSAP58, SRSF3, SLC45A3, SNRPD1, SNRPD3, SNRPN, SRSF9, TMEM232, TNFAIP1, TRAPPC8, USP9Y, USP9X, EIF3C, EIF3M, RC3H2, ATG16L1, GBF1, DCAF15, BICD2, PSMD14, DYRK1A, nsp8ab, SQSTM1, PLEKHA4, PINK1, LINC01554, TRIM6, DOK2, RAB5A, KIAA1211L, GATAD2A, PHACTR1, nsp1, ESR1, LAMTOR5, EIF4A2, CHMP4C, PRNP, FASN, HNRNPH1, INS, Rnf183, BRD4, CIC, Apc2, RBM39, FBP1, CSPG4, IFI16, GRB7, TXNIP, TBK1, IKBKE, PRDM13, TDRD5, PLK4, UFL1, TP53, SERBP1, FZR1, PAGE4, NUDCD2, NAA40, NIF3L1, RANBP10, NCOA5, NLRP7, AGO2, TOLLIP, SLFN11, MAGEL2, |
Top |
|
Clinically associated variants from ClinVar. |
Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
SNVs and Indels |
Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
EIF4B | PAAD | chr12 | 53421850 | 53421850 | G | A | Missense_Mutation | p.R286H | 5 |
EIF4B | KIRP | chr12 | 53416313 | 53416313 | G | C | Missense_Mutation | p.R190P | 4 |
EIF4B | BRCA | chr12 | 53413733 | 53413733 | G | C | Missense_Mutation | p.E134Q | 4 |
EIF4B | SKCM | chr12 | 53421577 | 53421577 | C | T | Missense_Mutation | p.R227C | 4 |
EIF4B | UCEC | chr12 | 53421677 | 53421677 | A | G | Missense_Mutation | p.D260G | 3 |
EIF4B | UCEC | chr12 | 53412783 | 53412783 | G | T | Missense_Mutation | p.G118V | 3 |
EIF4B | KIRC | chr12 | 53427591 | 53427592 | - | C | Splice_Site | p.GP327_splice | 3 |
EIF4B | PAAD | chr12 | 53427635 | 53427635 | C | A | Missense_Mutation | p.P342H | 3 |
EIF4B | LUAD | chr12 | 53427616 | 53427616 | C | G | Missense_Mutation | p.L336V | 3 |
EIF4B | PAAD | chr12 | 53421816 | 53421816 | G | T | Missense_Mutation | p.G275C | 3 |
EIF4B | KIRP | chr12 | 53431279 | 53431279 | C | T | Missense_Mutation | p.P465S | 3 |
EIF4B | HNSC | chr12 | 53410391 | 53410391 | G | C | Missense_Mutation | p.D50H | 3 |
EIF4B | UCS | chr12 | 53433961 | 53433961 | C | G | Missense_Mutation | p.S597C | 3 |
EIF4B | SKCM | chr12 | 53421881 | 53421881 | C | T | Silent | p.D296D | 2 |
EIF4B | LGG | chr12 | 53431273 | 53431273 | A | G | Missense_Mutation | 2 | |
EIF4B | STAD | chr12 | 53433975 | 53433975 | G | C | Missense_Mutation | p.D602H | 2 |
EIF4B | LUAD | chr12 | 53412608 | 53412608 | G | A | Missense_Mutation | p.D60N | 2 |
EIF4B | SKCM | chr12 | 53421854 | 53421854 | G | A | Silent | p.R287R | 2 |
EIF4B | PAAD | chr12 | 53427635 | 53427635 | C | A | Missense_Mutation | 2 | |
EIF4B | STAD | chr12 | 53412624 | 53412624 | C | T | Missense_Mutation | p.A65V | 2 |
EIF4B | LUAD | chr12 | 53427638 | 53427638 | A | G | Missense_Mutation | p.K343R | 2 |
EIF4B | SKCM | chr12 | 53431199 | 53431199 | G | A | Missense_Mutation | p.R438Q | 2 |
EIF4B | STAD | chr12 | 53413753 | 53413753 | T | C | Silent | p.G140G | 2 |
EIF4B | LUAD | chr12 | 53421875 | 53421875 | C | T | Silent | p.G294G | 2 |
EIF4B | BLCA | chr12 | 53412671 | 53412671 | C | A | Silent | p.R81R | 2 |
EIF4B | UCEC | chr12 | 53427591 | 53427592 | - | C | Frame_Shift_Ins | p.G327fs | 2 |
EIF4B | UCEC | chr12 | 53410335 | 53410335 | G | T | Missense_Mutation | p.S31I | 2 |
EIF4B | ESCA | chr12 | 53400186 | 53400186 | C | T | Missense_Mutation | 2 | |
EIF4B | LIHC | chr12 | 53431226 | 53431226 | A | - | Frame_Shift_Del | p.E447fs | 2 |
EIF4B | UCEC | chr12 | 53412757 | 53412757 | A | C | Missense_Mutation | p.E109D | 2 |
EIF4B | LIHC | chr12 | 53432144 | 53432144 | G | - | Frame_Shift_Del | p.G510fs | 2 |
EIF4B | TGCT | chr12 | 53410339 | 53410339 | C | G | Silent | 2 | |
EIF4B | SKCM | chr12 | 53427596 | 53427596 | C | T | Missense_Mutation | p.P329L | 2 |
EIF4B | UCEC | chr12 | 53416289 | 53416289 | G | A | Missense_Mutation | p.R182H | 2 |
EIF4B | HNSC | chr12 | 53410267 | 53410267 | G | C | Missense_Mutation | p.K8N | 2 |
EIF4B | TGCT | chr12 | 53410339 | 53410339 | C | G | Silent | p.T32T | 2 |
EIF4B | SKCM | chr12 | 53421572 | 53421572 | G | A | Missense_Mutation | p.R225Q | 2 |
EIF4B | UCEC | chr12 | 53421946 | 53421946 | G | A | Missense_Mutation | p.R318Q | 2 |
EIF4B | CESC | chr12 | 53421858 | 53421858 | G | A | Missense_Mutation | 2 | |
EIF4B | LAML | chr12 | 51699990 | 51699990 | C | G | Silent | p.P130 | 2 |
EIF4B | STAD | chr12 | 53412625 | 53412625 | G | A | Silent | p.A65A | 2 |
EIF4B | LUAD | chr12 | 53431372 | 53431372 | C | G | Missense_Mutation | p.Q496E | 2 |
EIF4B | SKCM | chr12 | 53427604 | 53427604 | C | T | Missense_Mutation | p.P332S | 2 |
EIF4B | BLCA | chr12 | 53433926 | 53433926 | G | C | Splice_Site | 2 | |
EIF4B | STAD | chr12 | 53428436 | 53428436 | C | T | Missense_Mutation | p.R417W | 2 |
EIF4B | STAD | chr12 | 53421886 | 53421886 | A | G | Missense_Mutation | p.Y298C | 2 |
EIF4B | BLCA | chr12 | 53410385 | 53410385 | G | A | Missense_Mutation | 1 | |
EIF4B | KICH | chr12 | 53416356 | 53416356 | T | C | Silent | p.A204A | 1 |
EIF4B | CESC | chr12 | 53421858 | 53421858 | G | A | Missense_Mutation | p.D289N | 1 |
EIF4B | PAAD | chr12 | 53421850 | 53421850 | G | A | Missense_Mutation | 1 | |
EIF4B | SARC | chr12 | 53427672 | 53427672 | C | T | Silent | 1 | |
EIF4B | THYM | chr12 | 53400247 | 53400247 | G | A | RNA | NULL | 1 |
EIF4B | HNSC | chr12 | 53400274 | 53400275 | - | - | Frame_Shift_Ins | 1 | |
EIF4B | BLCA | chr12 | 53413805 | 53413805 | G | A | Missense_Mutation | 1 | |
EIF4B | KIRC | chr12 | 53416324 | 53416324 | A | - | Frame_Shift_Del | p.D193fs | 1 |
EIF4B | CESC | chr12 | 53410310 | 53410310 | G | T | Nonsense_Mutation | p.E23* | 1 |
EIF4B | LGG | chr12 | 53412780 | 53412780 | G | T | Missense_Mutation | 1 | |
EIF4B | SARC | chr12 | 53427627 | 53427627 | G | A | Silent | 1 | |
EIF4B | HNSC | chr12 | 53400278 | 53400278 | C | T | Missense_Mutation | 1 | |
EIF4B | BLCA | chr12 | 53421930 | 53421930 | A | C | Silent | p.R313R | 1 |
EIF4B | KIRC | chr12 | 53412776 | 53412776 | T | C | Missense_Mutation | p.F116L | 1 |
EIF4B | COAD | chr12 | 53428410 | 53428410 | G | A | Missense_Mutation | p.R408Q | 1 |
EIF4B | LIHC | chr12 | 53412615 | 53412615 | T | C | Missense_Mutation | 1 | |
EIF4B | SARC | chr12 | 53427627 | 53427627 | G | A | Silent | p.R339R | 1 |
EIF4B | HNSC | chr12 | 53433969 | 53433969 | G | A | Missense_Mutation | 1 | |
EIF4B | SKCM | chr12 | 53413733 | 53413733 | G | A | Missense_Mutation | p.E134K | 1 |
EIF4B | ESCA | chr12 | 53400172 | 53400172 | C | - | RNA | NULL | 1 |
EIF4B | LIHC | chr12 | 53413702 | 53413702 | A | G | Silent | p.A123A | 1 |
EIF4B | STAD | chr12 | 53412753 | 53412753 | C | T | Missense_Mutation | p.T108I | 1 |
EIF4B | SARC | chr12 | 53427672 | 53427672 | C | T | Silent | p.S354S | 1 |
EIF4B | HNSC | chr12 | 53421933 | 53421933 | G | C | Missense_Mutation | p.D314H | 1 |
EIF4B | SKCM | chr12 | 53421634 | 53421634 | C | T | Missense_Mutation | p.R246C | 1 |
EIF4B | BLCA | chr12 | 53410385 | 53410385 | G | A | Missense_Mutation | p.E48K | 1 |
EIF4B | ESCA | chr12 | 53400186 | 53400186 | C | T | RNA | NULL | 1 |
EIF4B | LIHC | chr12 | 53427592 | 53427592 | C | - | Frame_Shift_Del | p.G327fs | 1 |
EIF4B | STAD | chr12 | 53428437 | 53428437 | G | A | Missense_Mutation | p.R417Q | 1 |
EIF4B | SARC | chr12 | 53427672 | 53427672 | C | T | Silent | p.S354 | 1 |
EIF4B | HNSC | chr12 | 53433969 | 53433969 | G | A | Missense_Mutation | p.G600S | 1 |
EIF4B | LUAD | chr12 | 53427591 | 53427591 | T | C | Splice_Site | p.G327_splice | 1 |
EIF4B | SKCM | chr12 | 53413721 | 53413721 | C | T | Missense_Mutation | p.P130S | 1 |
EIF4B | BLCA | chr12 | 53413718 | 53413718 | G | A | Missense_Mutation | p.E129K | 1 |
EIF4B | KIRP | chr12 | 53432173 | 53432173 | T | C | Silent | p.S518S | 1 |
EIF4B | PRAD | chr12 | 53412636 | 53412636 | A | G | Missense_Mutation | p.D69G | 1 |
EIF4B | STAD | chr12 | 53412753 | 53412753 | C | T | Missense_Mutation | 1 | |
EIF4B | SARC | chr12 | 53427627 | 53427627 | G | A | Silent | p.R339 | 1 |
EIF4B | HNSC | chr12 | 53400278 | 53400278 | C | T | Missense_Mutation | p.S4L | 1 |
EIF4B | LUSC | chr12 | 53428431 | 53428431 | G | T | Missense_Mutation | p.R415L | 1 |
EIF4B | LUSC | chr12 | 53427811 | 53427811 | C | T | Missense_Mutation | p.R401W | 1 |
EIF4B | SKCM | chr12 | 53412708 | 53412708 | C | G | Missense_Mutation | p.S93W | 1 |
EIF4B | BLCA | chr12 | 53413805 | 53413805 | G | A | Missense_Mutation | p.E158K | 1 |
EIF4B | GBM | chr12 | 53421578 | 53421578 | G | A | Missense_Mutation | p.R227H | 1 |
EIF4B | PRAD | chr12 | 53421650 | 53421650 | G | A | Missense_Mutation | p.R251Q | 1 |
EIF4B | KIRP | chr12 | 53416313 | 53416313 | G | C | Missense_Mutation | 1 | |
EIF4B | LUSC | chr12 | 53421697 | 53421697 | G | C | Missense_Mutation | p.D267H | 1 |
EIF4B | STAD | chr12 | 53412625 | 53412625 | G | A | Silent | 1 | |
EIF4B | HNSC | chr12 | 53421933 | 53421933 | G | C | Missense_Mutation | 1 | |
EIF4B | LIHC | chr12 | 53427592 | 53427592 | C | - | Frame_Shift_Del | p.P329fs | 1 |
EIF4B | SARC | chr12 | 53413725 | 53413725 | G | C | Missense_Mutation | 1 | |
EIF4B | HNSC | chr12 | 53421849 | 53421849 | C | T | Missense_Mutation | p.R286C | 1 |
EIF4B | LUSC | chr12 | 53431196 | 53431196 | C | T | Missense_Mutation | p.A437V | 1 |
EIF4B | HNSC | chr12 | 53421849 | 53421849 | C | T | Missense_Mutation | 1 | |
EIF4B | SARC | chr12 | 53416400 | 53416400 | G | T | Missense_Mutation | 1 | |
EIF4B | THYM | chr12 | 53433087 | 53433087 | G | T | Missense_Mutation | 1 | |
EIF4B | UCS | chr12 | 53433961 | 53433961 | C | G | Missense_Mutation | 1 | |
EIF4B | CESC | chr12 | 53410310 | 53410310 | G | T | Nonsense_Mutation | 1 | |
EIF4B | LGG | chr12 | 53431273 | 53431273 | A | G | Missense_Mutation | p.K463E | 1 |
EIF4B | LUSC | chr12 | 53410353 | 53410353 | C | A | Missense_Mutation | p.P37Q | 1 |
EIF4B | THYM | chr12 | 53413766 | 53413766 | G | T | Nonsense_Mutation | p.E145X | 1 |
EIF4B | HNSC | chr12 | 53410267 | 53410267 | G | C | Missense_Mutation | 1 | |
EIF4B | LUAD | chr12 | 53431327 | 53431327 | G | C | Missense_Mutation | p.E481Q | 1 |
EIF4B | SARC | chr12 | 53433048 | 53433048 | G | T | Missense_Mutation | 1 | |
EIF4B | BLCA | chr12 | 53412671 | 53412671 | C | A | Silent | 1 | |
EIF4B | HNSC | chr12 | 53400274 | 53400275 | - | C | Frame_Shift_Ins | p.L3fs | 1 |
EIF4B | CESC | chr12 | 53431271 | 53431271 | C | G | Missense_Mutation | 1 | |
EIF4B | LGG | chr12 | 53412741 | 53412741 | C | T | Missense_Mutation | p.P104L | 1 |
EIF4B | PAAD | chr12 | 53421816 | 53421816 | G | T | Missense_Mutation | 1 | |
EIF4B | SARC | chr12 | 53433481 | 53433481 | G | T | Missense_Mutation | 1 | |
EIF4B | THYM | chr12 | 53433087 | 53433087 | G | T | Missense_Mutation | p.G548C | 1 |
EIF4B | HNSC | chr12 | 53410391 | 53410391 | G | C | Missense_Mutation | 1 | |
EIF4B | LUAD | chr12 | 53413716 | 53413716 | G | T | Missense_Mutation | p.R128L | 1 |
Copy number variation (CNV) of EIF4B * Click on the image to open the original image in a new window. |
Fusion gene breakpoints (product of the structural variants (SVs)) across EIF4B * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion genes with this translation factor from FusionGDB2.0. |
FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
101952 | STAD | TCGA-D7-A4YT | ADAP1 | chr7 | 994031 | - | EIF4B | chr12 | 53427589 | + |
101952 | STAD | TCGA-D7-A4YT-01A | ADAP1 | chr7 | 985398 | - | EIF4B | chr12 | 53427590 | + |
101952 | STAD | TCGA-D7-A4YT-01A | ADAP1 | chr7 | 994032 | - | EIF4B | chr12 | 53427590 | + |
92821 | STAD | TCGA-D7-A4YT | EIF4B | chr12 | 53421972 | + | ADAP1 | chr7 | 975141 | - |
25966 | HNSC | TCGA-BA-5152 | EIF4B | chr12 | 53400280 | + | C19orf71 | chr19 | 3543232 | + |
82974 | STAD | TCGA-D7-A4YT-01A | EIF4B | chr12 | 53421972 | + | COX19 | chr7 | 975141 | - |
85888 | N/A | BF340503 | EIF4B | chr12 | 53435988 | + | FAM53C | chr5 | 137678717 | + |
95270 | N/A | BF829819 | EIF4B | chr12 | 53435656 | + | KMT2D | chr12 | 49431501 | - |
80172 | N/A | AA736805 | EIF4B | chr12 | 53435937 | + | LHFPL3 | chr7 | 104311984 | - |
103326 | ESCA | TCGA-R6-A6L6 | EIF4B | chr12 | 53416411 | + | RNPC3 | chr1 | 104097655 | + |
103283 | UCEC | TCGA-EO-A3AY | EIF4B | chr12 | 53431406 | + | RPLP0 | chr12 | 120635265 | - |
85320 | N/A | BG213873 | EIF4B | chr12 | 53408728 | + | TNNC1 | chr3 | 52486122 | + |
101952 | N/A | BF882453 | FYTTD1 | chr3 | 197481885 | + | EIF4B | chr12 | 53435318 | + |
101952 | N/A | BI491355 | MYL1 | chr2 | 211171731 | + | EIF4B | chr12 | 53435993 | - |
101952 | N/A | FN093739 | SEMA5A | chr5 | 9496148 | + | EIF4B | chr12 | 53435058 | + |
101952 | SKCM | TCGA-EE-A29D-06A | TMTC3 | chr12 | 88570096 | - | EIF4B | chr12 | 53410257 | + |
101955 | N/A | AW386153 | ZNF384 | chr12 | 6775904 | - | EIF4B | chr12 | 53433209 | - |
Top |
|
Kaplan-Meier plots with logrank tests of overall survival (OS) |
Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
Top |
|
Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
TGCT | EIF4B | 0.0306805619471656 | 0.86 |
LUAD | EIF4B | 0.0425135570423456 | 1 |
Top |
|
Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
LUAD | EIF4B | 0.00259391837660188 | 0.086 |
LGG | EIF4B | 0.0210150298309777 | 0.67 |
THYM | EIF4B | 0.0383557436267372 | 1 |
SARC | EIF4B | 0.0427072128644206 | 1 |
Top |
|
Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
|
Diseases associated with this translation factor. (DisGeNet 4.0) |
Disease ID | Disease Name | # PubMeds | Disease source |
C0041696 | Unipolar Depression | 1 | PSYGENET |
C1269683 | Major Depressive Disorder | 1 | PSYGENET |