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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: EIF4EBP2 (NCBI Gene ID:1979)


Gene Summary

check button Gene Summary
Gene InformationGene Name: EIF4EBP2
Gene ID: 1979
Gene Symbol

EIF4EBP2

Gene ID

1979

Gene Nameeukaryotic translation initiation factor 4E binding protein 2
Synonyms4EBP2|PHASII
Cytomap

10q22.1

Type of Geneprotein-coding
Descriptioneukaryotic translation initiation factor 4E-binding protein 24E-BP2eIF4E-binding protein 2phosphorylated, heat and acid stable regulated by insulin protein II
Modification date20200313
UniProtAcc

Q13542


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0017148Negative regulation of translation
GO:0006417Regulation of translation
GO:0006413Translational initiation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF4EBP2(733 - 1119.25]


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Translation Studies in PubMed

check button We searched PubMed using 'EIF4EBP2[title] AND translation [title] AND human.'
GeneTitlePMID
EIF4EBP2..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
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check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
KIRPEIF4EBP2-1.565988253282310.000234263017773628
STADEIF4EBP2-1.317471765024360.000713176093995571
BRCAEIF4EBP2-2.120941170765364.28343095744558e-22
PRADEIF4EBP21.542262592497549.23299304763812e-08
COADEIF4EBP2-2.262228762510369.83476638793947e-07


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue
KIRPEIF4EBP2hsa-miR-182-5p860.3308422590068160.00303481856701657
KIRPEIF4EBP2hsa-miR-96-5p970.3208130477117820.00409968705958751


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
PCPGEIF4EBP2120.001994818317616050.1533018750.2718330081300810.128800959081040.307580608471235
READEIF4EBP2120.006789936609065730.1583475862068970.243455416666667-0.328432553850097-0.102939665918983

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
LGGEIF4EBP20.0762534370.03067111
CESCEIF4EBP2-0.0470584720.038230225

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with EIF4EBP2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
KIRCEIF4EBP2RPS6-3.45560582778030.0001224322154943
PRADEIF4EBP2RPS6KB11.250475019811980.000199084406212897
KICHEIF4EBP2RPS6KB2-4.220265548708880.000911891460418701
KICHEIF4EBP2EIF4EBP31.97598164181750.00102710723876953
THCAEIF4EBP2RPS6KB2-1.025161997531190.00125200545023797
COADEIF4EBP2RPS6KB1-1.11330695676780.00144392251968384
PRADEIF4EBP2EIF4EBP1-1.527304066362960.00170492480464144
ESCAEIF4EBP2TSC2-3.249192076274690.001953125
BRCAEIF4EBP2EIF4EBP3-1.228716755609180.00216137798426823
THCAEIF4EBP2RPS61.463461436653890.00305071956645465
KIRPEIF4EBP2EIF4EBP31.309693880029570.0038655917160213
CHOLEIF4EBP2RPTOR-2.343171879166640.00390625
KICHEIF4EBP2EIF4G1-1.466560811507430.00612920522689819
LUSCEIF4EBP2TSC21.125044985032330.00646935999315137
KIRPEIF4EBP2RPS6-1.153609078341590.0111397774890065
COADEIF4EBP2RPS61.033795895208510.011966735124588
BLCAEIF4EBP2RPS6-1.769407775799380.012359619140625
ESCAEIF4EBP2EIF4EBP32.983246886128860.013671875
STADEIF4EBP2TSC2-1.661303967459170.018431528005749
HNSCEIF4EBP2EIF4EBP11.168881949266530.0196738412400919
HNSCEIF4EBP2RPS6KB1-1.279968097050290.0301271170746986
KIRPEIF4EBP2RPS6KB1-1.464654742843482.00420618057251e-06
KIRCEIF4EBP2EIF4EBP33.346302388840322.66680331214666e-11
KIRPEIF4EBP2EIF4EBP1-2.12238544916882.98023223876953e-07
LIHCEIF4EBP2TSC2-2.061242595042813.59406613648813e-06
KICHEIF4EBP2TSC2-5.673402954959296.36577606201172e-05
LUADEIF4EBP2EIF4EBP1-2.826914794568296.51132046672323e-08
KICHEIF4EBP2EIF4E1.616752105626716.55651092529297e-06
LIHCEIF4EBP2RPTOR-4.363622704361356.64579404273587e-07
BRCAEIF4EBP2RPS6KB2-1.613616500271856.83985375255908e-15
PRADEIF4EBP2MTOR2.457673762698948.16442831201447e-07
BRCAEIF4EBP2EIF4EBP1-1.8674303125428.26346922422571e-07
KIRCEIF4EBP2EIF4EBP1-3.148604668796019.40007073737459e-12


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with EIF4EBP2
EIF4E, ELAVL1, MTOR, BAG3, RPTOR, ARHGAP17, HNRNPA2B1, TXN, TBCA, EIF4E2, NFYA, RDH12, LSM3, FHL3, CDK4, EIF4ENIF1, EIF4EBP1, EIF4G1, EIF4G3, EIF4A2, EIF3B, EIF3D, EIF3C, EIF3L, EIF3I, EIF3K, EIF3H, EIF3G, EIF3A, EIF3M, EIF3E, ANGEL1, RPS27L, EIF3F,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo
EIF4EBP2chr1072164174GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001583|missense_variantSO:0001583|missense_variant
EIF4EBP2chr1072164178CTsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
EIF4EBP2ESCAchr107217968772179687GTMissense_Mutationp.D55Y7
EIF4EBP2COADchr107217970972179709GCMissense_Mutationp.R62P4
EIF4EBP2LIHCchr107216427272164272G-Frame_Shift_Delp.G40fs3
EIF4EBP2ESCAchr107217968772179687GTMissense_Mutation2
EIF4EBP2UCECchr107217967672179676GAMissense_Mutationp.R51Q2
EIF4EBP2PAADchr107217970972179709GCMissense_Mutation2
EIF4EBP2BLCAchr107217969072179691AG-Frame_Shift_Delp.R56fs2
EIF4EBP2STADchr107217973972179739CTMissense_Mutationp.P72L2
EIF4EBP2STADchr107217985372179853TCMissense_Mutationp.V110A2
EIF4EBP2BLCAchr107217974672179746CTSilent1
EIF4EBP2THYMchr107217980772179807GTMissense_Mutation1
EIF4EBP2BLCAchr107217969072179691AG-Frame_Shift_Del1
EIF4EBP2THYMchr107217980772179807GTMissense_Mutationp.V95L1
EIF4EBP2BLCAchr107217969772179697TGMissense_Mutation1
EIF4EBP2LIHCchr107216418072164180GTMissense_Mutationp.G8V1
EIF4EBP2BLCAchr107217967672179676GTMissense_Mutation1
EIF4EBP2BLCAchr107217978972179789GTNonsense_Mutationp.E89*1
EIF4EBP2LUADchr107218148372181483CGMissense_Mutationp.Q115E1
EIF4EBP2BLCAchr107216422972164229CTSilentp.I24I1
EIF4EBP2BLCAchr107217969772179697TGMissense_Mutationp.F58C1
EIF4EBP2PRADchr107217974372179743CTSilentp.C73C1
EIF4EBP2SKCMchr107218147472181474GTMissense_Mutationp.D112Y1
EIF4EBP2COADchr107216427172164272-GFrame_Shift_Insp.P38fs1
EIF4EBP2STADchr107216427272164272G-Frame_Shift_Del1
EIF4EBP2COADchr107217974672179746CTSilentp.H74H1

check buttonCopy number variation (CNV) of EIF4EBP2
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across EIF4EBP2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
89452N/ABM150873CD70chr196584147-EIF4EBP2chr1072183667-
102023N/AFN088420EIF4EBP2chr1072188244-EIF3Hchr8117661079-
89452N/AAA278954EIF4EBP2chr1072187809+EIF4EBP2chr1072187684-
35116N/ABE091541EIF4EBP2chr1072182728-GSTM1chr1110236002-
47085N/ABF526065EIF4EBP2chr1072188374+HNRNPA1L2chr1353214046-
85632N/AAW603986EIF4EBP2chr1072181992+NTMchr11131913622+
89452N/ACA414218LDHAchr1118429072-EIF4EBP2chr1072181544-
89452N/ABE837785PARD3Bchr2205926524-EIF4EBP2chr1072186510+
89452N/ABP288018RBMS2chr1256965502+EIF4EBP2chr1072164149+
89452N/AW03794SERPING1chr1157382278+EIF4EBP2chr1072164079+
89452N/AAI738781SSBP3chr154692683+EIF4EBP2chr1072183278-
89458N/AAL561402TBCBchr1936606557+EIF4EBP2chr1072164111+


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
STADEIF4EBP20.02901905680842630.78
LUSCEIF4EBP20.03130127568080540.81
TGCTEIF4EBP21.58384969216625e-050.00044

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LGGEIF4EBP27.49063455802573e-092.5e-07
BRCAEIF4EBP20.006456772009126830.21

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0019193Hepatitis, Toxic1CTD_human
C1262760Hepatitis, Drug-Induced1CTD_human
C3658290Drug-Induced Acute Liver Injury1CTD_human
C4277682Chemical and Drug Induced Liver Injury1CTD_human
C4279912Chemically-Induced Liver Toxicity1CTD_human