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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF5A (NCBI Gene ID:1984)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF5A
	Gene ID: 1984
	Gene Symbol	EIF5A
	Gene ID	1984
	Gene Name	eukaryotic translation initiation factor 5A
	Synonyms	EIF-5A\|EIF5A1\|eIF-4D\|eIF5AI
	Cytomap	17p13.1
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 5A-1eukaryotic initiation factor 5Arev-binding factor
	Modification date	20200313
	UniProtAcc	P63241

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006415	Translational termination
GO:0008135	Translation factor activity, RNA binding
GO:0045727	Positive regulation of translation
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF5A	GO:0006913	nucleocytoplasmic transport	12210765
Hgene	EIF5A	GO:0006915	apoptotic process	15371445\|17187778

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF5A[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF5A	eIF5A Functions Globally in Translation Elongation and Termination	28392174

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000571955	7211799	7211894	5UTR-5UTR
ENST00000576930	7211799	7211894	5UTR-5UTR
ENST00000573542	7212915	7213119	5CDS-5UTR
ENST00000336458	7212933	7213119	5CDS-5UTR
ENST00000419711	7212933	7213119	5CDS-5UTR
ENST00000336458	7214336	7214441	In-frame
ENST00000416016	7214336	7214441	In-frame
ENST00000419711	7214336	7214441	In-frame
ENST00000571955	7214336	7214441	In-frame
ENST00000573542	7214336	7214441	In-frame
ENST00000576930	7214336	7214441	In-frame
ENST00000336458	7214668	7214800	In-frame
ENST00000416016	7214668	7214800	In-frame
ENST00000419711	7214668	7214800	In-frame
ENST00000571955	7214668	7214800	In-frame
ENST00000573542	7214668	7214800	In-frame
ENST00000576930	7214668	7214800	In-frame
ENST00000336458	7214896	7214970	3UTR-3CDS
ENST00000416016	7214896	7214970	3UTR-3CDS
ENST00000419711	7214896	7214970	3UTR-3CDS
ENST00000571955	7214896	7214970	3UTR-3CDS
ENST00000573542	7214896	7214970	3UTR-3CDS
ENST00000576930	7214896	7214970	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000573542	7214336	7214441	1106	356	460	154	55	90
ENST00000419711	7214336	7214441	1288	327	431	154	55	90
ENST00000416016	7214336	7214441	1353	392	496	154	55	90
ENST00000571955	7214336	7214441	1383	422	526	154	55	90
ENST00000576930	7214336	7214441	1456	495	599	154	55	90
ENST00000336458	7214336	7214441	1528	567	671	154	55	90
ENST00000573542	7214668	7214800	1106	461	592	154	90	134
ENST00000419711	7214668	7214800	1288	432	563	154	90	134
ENST00000416016	7214668	7214800	1353	497	628	154	90	134
ENST00000571955	7214668	7214800	1383	527	658	154	90	134
ENST00000576930	7214668	7214800	1456	600	731	154	90	134
ENST00000336458	7214668	7214800	1528	672	803	154	90	134

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
P63241	55	90	20	90	Region	Note=DOHH-binding
P63241	90	134	20	90	Region	Note=DOHH-binding
P63241	55	90	20	90	Region	Note=DOHH-binding
P63241	90	134	20	90	Region	Note=DOHH-binding
P63241	55	90	20	90	Region	Note=DOHH-binding
P63241	90	134	20	90	Region	Note=DOHH-binding
P63241	55	90	20	90	Region	Note=DOHH-binding
P63241	90	134	20	90	Region	Note=DOHH-binding
P63241	55	90	20	90	Region	Note=DOHH-binding
P63241	90	134	20	90	Region	Note=DOHH-binding
P63241	55	90	20	90	Region	Note=DOHH-binding
P63241	90	134	20	90	Region	Note=DOHH-binding
P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63242
P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63242
P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63242
P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63242
P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63242
P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P63242
P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18067580;Dbxref=PMID:18067580
P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18067580;Dbxref=PMID:18067580
P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18067580;Dbxref=PMID:18067580
P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18067580;Dbxref=PMID:18067580
P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18067580;Dbxref=PMID:18067580
P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18067580;Dbxref=PMID:18067580
P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16987817;Dbxref=PMID:16987817
P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16987817;Dbxref=PMID:16987817
P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16987817;Dbxref=PMID:16987817
P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16987817;Dbxref=PMID:16987817
P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16987817;Dbxref=PMID:16987817
P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16987817;Dbxref=PMID:16987817
P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF
P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3CPF

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	EIF5A	-2.36221705677847	0.000122033393260438
THCA	EIF5A	-1.78363731048148	0.000163107625527599
STAD	EIF5A	-3.31350115276852	0.00239070039242506
KICH	EIF5A	1.13226408826506	0.00308787822723389
ESCA	EIF5A	-1.53981930599908	0.013671875
LUAD	EIF5A	-3.54842210612043	1.73122747932354e-05
BRCA	EIF5A	-1.08858196408792	6.35242413482859e-13

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	EIF5A	hsa-miR-15a-5p	91	-0.358811285846439	0.0136906568900323
UVM	EIF5A	hsa-miR-497-5p	92	-0.364727361246349	0.00102239306694413

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUAD	EIF5A	-0.137163896	0.008519767
KICH	EIF5A	0.029844932	0.015752087
DLBC	EIF5A	0.030242349	0.023859606
COAD	EIF5A	0.025639254	0.044531137

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF5A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	TSG	EIF5A	PFN1	0.825795779	9.31E-305
DLBC	CGC	EIF5A	YWHAE	0.844402288	4.66E-14
DLBC	Epifactor	EIF5A	YWHAE	0.844402288	4.66E-14
GBM	Cell metabolism gene	EIF5A	PSMB3	0.812985275	8.86E-42
GBM	Cell metabolism gene	EIF5A	PSMB6	0.82318376	1.20E-43
GBM	Epifactor	EIF5A	C17orf49	0.850299283	2.92E-49
GBM	IUPHAR	EIF5A	PSMB6	0.82318376	1.20E-43
KICH	Cell metabolism gene	EIF5A	PFDN2	0.802993802	1.03E-21
KICH	Cell metabolism gene	EIF5A	DGUOK	0.804139658	8.20E-22
KICH	Cell metabolism gene	EIF5A	PSMB4	0.807941687	3.75E-22
KICH	Cell metabolism gene	EIF5A	SSR2	0.811835659	1.65E-22
KICH	Cell metabolism gene	EIF5A	PSMB6	0.814937962	8.46E-23
KICH	Cell metabolism gene	EIF5A	PSMB3	0.887469363	1.08E-31
KICH	CGC	EIF5A	ASPSCR1	0.818390243	3.97E-23
KICH	IUPHAR	EIF5A	PSMB6	0.814937962	8.46E-23
KICH	IUPHAR	EIF5A	CSNK2B	0.85068094	1.38E-26
KICH	TSG	EIF5A	PFN1	0.809529951	2.69E-22
KIRP	TSG	EIF5A	PFN1	0.87333877	2.73E-102
LIHC	TSG	EIF5A	GABARAP	0.801614651	4.24E-96
LUAD	Cell metabolism gene	EIF5A	PSMB6	0.802120255	1.24E-130
LUAD	IUPHAR	EIF5A	PSMB6	0.802120255	1.24E-130
MESO	Cell metabolism gene	EIF5A	PSMB6	0.83192827	1.87E-23
MESO	IUPHAR	EIF5A	PSMB6	0.83192827	1.87E-23
MESO	TSG	EIF5A	PFN1	0.817065005	4.92E-22
PCPG	Epifactor	EIF5A	C17orf49	0.805270763	7.30E-44
PCPG	TSG	EIF5A	GABARAP	0.824239453	1.43E-47
PCPG	TSG	EIF5A	PFN1	0.829163932	1.32E-48
READ	Cell metabolism gene	EIF5A	PSMB6	0.820648267	8.83E-27
READ	IUPHAR	EIF5A	PSMB6	0.820648267	8.83E-27
TGCT	Cell metabolism gene	EIF5A	G6PC3	0.805472938	8.11E-37
TGCT	Cell metabolism gene	EIF5A	NME1	0.809299438	2.06E-37
TGCT	Cell metabolism gene	EIF5A	PSMB6	0.86759771	1.39E-48
TGCT	Cell metabolism gene	EIF5A	PSMB3	0.869043705	6.32E-49
TGCT	Epifactor	EIF5A	AURKB	0.816652444	1.35E-38
TGCT	IUPHAR	EIF5A	AURKB	0.816652444	1.35E-38
TGCT	IUPHAR	EIF5A	PSMB6	0.86759771	1.39E-48
TGCT	Kinase	EIF5A	AURKB	0.816652444	1.35E-38
TGCT	TSG	EIF5A	NME1	0.809299438	2.06E-37
TGCT	TSG	EIF5A	PHB	0.820128095	3.57E-39
TGCT	TSG	EIF5A	PFN1	0.869658986	4.51E-49
THCA	Cell metabolism gene	EIF5A	PSMB4	0.817626318	8.79E-139
THCA	Cell metabolism gene	EIF5A	PSMB3	0.836211893	7.76E-151
THYM	Cell metabolism gene	EIF5A	POLR2I	0.80280064	1.01E-28
THYM	Cell metabolism gene	EIF5A	TOMM22	0.803260449	8.95E-29
THYM	Cell metabolism gene	EIF5A	DOHH	0.803549212	8.27E-29
THYM	Cell metabolism gene	EIF5A	POLR2J	0.804439388	6.48E-29
THYM	Cell metabolism gene	EIF5A	PMPCA	0.80506139	5.46E-29
THYM	Cell metabolism gene	EIF5A	SEC61G	0.80514677	5.33E-29
THYM	Cell metabolism gene	EIF5A	COX17	0.805780944	4.47E-29
THYM	Cell metabolism gene	EIF5A	PSMB4	0.807001611	3.19E-29
THYM	Cell metabolism gene	EIF5A	PSMA6	0.809263195	1.69E-29
THYM	Cell metabolism gene	EIF5A	TXN	0.81155819	8.79E-30
THYM	Cell metabolism gene	EIF5A	LSM5	0.811750702	8.32E-30
THYM	Cell metabolism gene	EIF5A	PFDN6	0.811785015	8.24E-30
THYM	Cell metabolism gene	EIF5A	FPGS	0.813516465	5.00E-30
THYM	Cell metabolism gene	EIF5A	SNRPE	0.813571535	4.92E-30
THYM	Cell metabolism gene	EIF5A	PSME2	0.81368678	4.76E-30
THYM	Cell metabolism gene	EIF5A	MTX1	0.814155103	4.15E-30
THYM	Cell metabolism gene	EIF5A	NOP56	0.816755088	1.94E-30
THYM	Cell metabolism gene	EIF5A	PSMB8	0.818639719	1.11E-30
THYM	Cell metabolism gene	EIF5A	SEC61B	0.820987855	5.45E-31
THYM	Cell metabolism gene	EIF5A	PGLS	0.821183489	5.14E-31
THYM	Cell metabolism gene	EIF5A	TIMM10	0.822496397	3.44E-31
THYM	Cell metabolism gene	EIF5A	SLC27A5	0.822779142	3.16E-31
THYM	Cell metabolism gene	EIF5A	WBSCR22	0.823964696	2.19E-31
THYM	Cell metabolism gene	EIF5A	NT5M	0.824110732	2.10E-31
THYM	Cell metabolism gene	EIF5A	GALK1	0.825337781	1.43E-31
THYM	Cell metabolism gene	EIF5A	NME1	0.825526931	1.35E-31
THYM	Cell metabolism gene	EIF5A	PSME1	0.829738676	3.56E-32
THYM	Cell metabolism gene	EIF5A	LSM2	0.830343599	2.93E-32
THYM	Cell metabolism gene	EIF5A	PSMD4	0.8306033	2.69E-32
THYM	Cell metabolism gene	EIF5A	TIMM50	0.831160237	2.25E-32
THYM	Cell metabolism gene	EIF5A	GEMIN6	0.832228357	1.59E-32
THYM	Cell metabolism gene	EIF5A	AAAS	0.832952637	1.26E-32
THYM	Cell metabolism gene	EIF5A	ACOT8	0.834748977	6.94E-33
THYM	Cell metabolism gene	EIF5A	PGP	0.835660334	5.13E-33
THYM	Cell metabolism gene	EIF5A	NANS	0.836575149	3.78E-33
THYM	Cell metabolism gene	EIF5A	ITPA	0.837723695	2.56E-33
THYM	Cell metabolism gene	EIF5A	SNRPB	0.839173615	1.57E-33
THYM	Cell metabolism gene	EIF5A	APRT	0.839555797	1.37E-33
THYM	Cell metabolism gene	EIF5A	EXOSC1	0.840664757	9.39E-34
THYM	Cell metabolism gene	EIF5A	TIMM13	0.842600523	4.79E-34
THYM	Cell metabolism gene	EIF5A	TOMM5	0.846535546	1.19E-34
THYM	Cell metabolism gene	EIF5A	EXOSC4	0.84710426	9.67E-35
THYM	Cell metabolism gene	EIF5A	EXOSC5	0.847728478	7.71E-35
THYM	Cell metabolism gene	EIF5A	PSMB7	0.847916942	7.20E-35
THYM	Cell metabolism gene	EIF5A	HMBS	0.84941439	4.17E-35
THYM	Cell metabolism gene	EIF5A	GEMIN7	0.849881648	3.51E-35
THYM	Cell metabolism gene	EIF5A	PSMB10	0.850285528	3.02E-35
THYM	Cell metabolism gene	EIF5A	DGKZ	0.85227433	1.44E-35
THYM	Cell metabolism gene	EIF5A	EBP	0.853178566	1.03E-35
THYM	Cell metabolism gene	EIF5A	POLR3K	0.853483715	9.15E-36
THYM	Cell metabolism gene	EIF5A	PSMC3	0.857209703	2.19E-36
THYM	Cell metabolism gene	EIF5A	SNRPD1	0.857813285	1.73E-36
THYM	Cell metabolism gene	EIF5A	PSMD13	0.860999656	4.91E-37
THYM	Cell metabolism gene	EIF5A	SNRPD2	0.862594533	2.58E-37
THYM	Cell metabolism gene	EIF5A	PAFAH1B3	0.86326618	1.96E-37
THYM	Cell metabolism gene	EIF5A	TIMM17B	0.865521693	7.76E-38
THYM	Cell metabolism gene	EIF5A	POLR2H	0.86564624	7.37E-38
THYM	Cell metabolism gene	EIF5A	TSTA3	0.865932046	6.55E-38
THYM	Cell metabolism gene	EIF5A	SNRPF	0.866443886	5.29E-38
THYM	Cell metabolism gene	EIF5A	SRM	0.868091091	2.64E-38
THYM	Cell metabolism gene	EIF5A	DGUOK	0.869356061	1.54E-38
THYM	Cell metabolism gene	EIF5A	PHKG2	0.8716508	5.72E-39
THYM	Cell metabolism gene	EIF5A	GUK1	0.871993995	4.92E-39
THYM	Cell metabolism gene	EIF5A	PSMB6	0.87261785	3.74E-39
THYM	Cell metabolism gene	EIF5A	TOMM40	0.875291313	1.14E-39
THYM	Cell metabolism gene	EIF5A	TIMM8B	0.877016975	5.20E-40
THYM	Cell metabolism gene	EIF5A	DTYMK	0.877724906	3.76E-40
THYM	Cell metabolism gene	EIF5A	PSMA4	0.881633432	6.04E-41
THYM	Cell metabolism gene	EIF5A	PSMB3	0.884871683	1.26E-41
THYM	Cell metabolism gene	EIF5A	TBCB	0.899500053	5.69E-45
THYM	Cell metabolism gene	EIF5A	LSM4	0.900325989	3.55E-45
THYM	CGC	EIF5A	RECQL4	0.825900739	1.20E-31
THYM	CGC	EIF5A	COX6C	0.831581517	1.96E-32
THYM	CGC	EIF5A	TFPT	0.837247967	3.01E-33
THYM	CGC	EIF5A	SDHAF2	0.843168267	3.93E-34
THYM	Epifactor	EIF5A	HIST2H2AC	0.800298835	1.99E-28
THYM	Epifactor	EIF5A	PRPF31	0.805029372	5.51E-29
THYM	Epifactor	EIF5A	CXXC1	0.806395147	3.77E-29
THYM	Epifactor	EIF5A	MAZ	0.807983889	2.42E-29
THYM	Epifactor	EIF5A	INO80E	0.809905043	1.41E-29
THYM	Epifactor	EIF5A	RBX1	0.81119678	9.75E-30
THYM	Epifactor	EIF5A	CDK5	0.81298802	5.83E-30
THYM	Epifactor	EIF5A	PRMT1	0.817531881	1.54E-30
THYM	Epifactor	EIF5A	SIRT7	0.820068453	7.20E-31
THYM	Epifactor	EIF5A	ZNHIT1	0.825498101	1.36E-31
THYM	Epifactor	EIF5A	ZGPAT	0.829077417	4.40E-32
THYM	Epifactor	EIF5A	PRR14	0.832924094	1.27E-32
THYM	Epifactor	EIF5A	TFPT	0.837247967	3.01E-33
THYM	Epifactor	EIF5A	EXOSC1	0.840664757	9.39E-34
THYM	Epifactor	EIF5A	EXOSC4	0.84710426	9.67E-35
THYM	Epifactor	EIF5A	PPM1G	0.84748518	8.42E-35
THYM	Epifactor	EIF5A	EXOSC5	0.847728478	7.71E-35
THYM	Epifactor	EIF5A	NAP1L4	0.849338844	4.29E-35
THYM	Epifactor	EIF5A	RUVBL2	0.858594921	1.27E-36
THYM	Epifactor	EIF5A	BRMS1	0.858700399	1.22E-36
THYM	Epifactor	EIF5A	SIRT6	0.865295799	8.53E-38
THYM	Epifactor	EIF5A	PPP4C	0.883420869	2.56E-41
THYM	Epifactor	EIF5A	C17orf49	0.883591591	2.36E-41
THYM	Epifactor	EIF5A	TAF10	0.891298785	4.90E-43
THYM	IUPHAR	EIF5A	CDK5	0.81298802	5.83E-30
THYM	IUPHAR	EIF5A	RNPEPL1	0.813045416	5.73E-30
THYM	IUPHAR	EIF5A	FKBP1A	0.813865818	4.52E-30
THYM	IUPHAR	EIF5A	ECE2	0.814141591	4.17E-30
THYM	IUPHAR	EIF5A	DYRK4	0.814371148	3.90E-30
THYM	IUPHAR	EIF5A	TOP1MT	0.814390471	3.88E-30
THYM	IUPHAR	EIF5A	PRMT1	0.817531881	1.54E-30
THYM	IUPHAR	EIF5A	PSMB8	0.818639719	1.11E-30
THYM	IUPHAR	EIF5A	DPP7	0.819735474	7.96E-31
THYM	IUPHAR	EIF5A	SIRT7	0.820068453	7.20E-31
THYM	IUPHAR	EIF5A	SLC27A5	0.822779142	3.16E-31
THYM	IUPHAR	EIF5A	NT5M	0.824110732	2.10E-31
THYM	IUPHAR	EIF5A	PPIA	0.845326295	1.83E-34
THYM	IUPHAR	EIF5A	SIRT6	0.865295799	8.53E-38
THYM	IUPHAR	EIF5A	MPDU1	0.8714833	6.15E-39
THYM	IUPHAR	EIF5A	PHKG2	0.8716508	5.72E-39
THYM	IUPHAR	EIF5A	PSMB6	0.87261785	3.74E-39
THYM	Kinase	EIF5A	CDK5	0.81298802	5.83E-30
THYM	Kinase	EIF5A	DYRK4	0.814371148	3.90E-30
THYM	Kinase	EIF5A	PHKG2	0.8716508	5.72E-39
THYM	TF	EIF5A	PIN1	0.803920596	7.47E-29
THYM	TF	EIF5A	IRF3	0.804322633	6.69E-29
THYM	TF	EIF5A	CXXC1	0.806395147	3.77E-29
THYM	TF	EIF5A	GLI4	0.80653578	3.63E-29
THYM	TF	EIF5A	ZNF444	0.806809104	3.36E-29
THYM	TF	EIF5A	MAZ	0.807983889	2.42E-29
THYM	TF	EIF5A	THYN1	0.809973443	1.38E-29
THYM	TF	EIF5A	ZNF428	0.817727884	1.45E-30
THYM	TF	EIF5A	SNAPC2	0.818051859	1.32E-30
THYM	TF	EIF5A	USF1	0.828651214	5.04E-32
THYM	TF	EIF5A	ZGPAT	0.829077417	4.40E-32
THYM	TF	EIF5A	ZNF787	0.830352554	2.92E-32
THYM	TF	EIF5A	ZNF511	0.842095802	5.71E-34
THYM	TF	EIF5A	DRAP1	0.849014315	4.83E-35
THYM	TF	EIF5A	GTF3A	0.852535368	1.31E-35
THYM	TF	EIF5A	ZNF688	0.854311471	6.68E-36
THYM	TF	EIF5A	ZNF668	0.889779771	1.08E-42
THYM	TSG	EIF5A	PIN1	0.803920596	7.47E-29
THYM	TSG	EIF5A	TSSC4	0.804021902	7.26E-29
THYM	TSG	EIF5A	IRF3	0.804322633	6.69E-29
THYM	TSG	EIF5A	AIP	0.806698737	3.47E-29
THYM	TSG	EIF5A	GADD45GIP1	0.809234249	1.70E-29
THYM	TSG	EIF5A	ST20	0.809888041	1.42E-29
THYM	TSG	EIF5A	PYCARD	0.815370891	2.91E-30
THYM	TSG	EIF5A	GABARAP	0.820089452	7.16E-31
THYM	TSG	EIF5A	NME1	0.825526931	1.35E-31
THYM	TSG	EIF5A	BRMS1	0.858700399	1.22E-36
THYM	TSG	EIF5A	SIRT6	0.865295799	8.53E-38
THYM	TSG	EIF5A	ZNF668	0.889779771	1.08E-42
THYM	TSG	EIF5A	PFN1	0.907896398	3.91E-47
UCS	Cell metabolism gene	EIF5A	POLR2I	0.80280064	1.01E-28
UCS	Cell metabolism gene	EIF5A	TOMM22	0.803260449	8.95E-29
UCS	Cell metabolism gene	EIF5A	DOHH	0.803549212	8.27E-29
UCS	Cell metabolism gene	EIF5A	POLR2J	0.804439388	6.48E-29
UCS	Cell metabolism gene	EIF5A	PMPCA	0.80506139	5.46E-29
UCS	Cell metabolism gene	EIF5A	SEC61G	0.80514677	5.33E-29
UCS	Cell metabolism gene	EIF5A	COX17	0.805780944	4.47E-29
UCS	Cell metabolism gene	EIF5A	PSMB4	0.807001611	3.19E-29
UCS	Cell metabolism gene	EIF5A	PSMA6	0.809263195	1.69E-29
UCS	Cell metabolism gene	EIF5A	TXN	0.81155819	8.79E-30
UCS	Cell metabolism gene	EIF5A	LSM5	0.811750702	8.32E-30
UCS	Cell metabolism gene	EIF5A	PFDN6	0.811785015	8.24E-30
UCS	Cell metabolism gene	EIF5A	FPGS	0.813516465	5.00E-30
UCS	Cell metabolism gene	EIF5A	SNRPE	0.813571535	4.92E-30
UCS	Cell metabolism gene	EIF5A	PSME2	0.81368678	4.76E-30
UCS	Cell metabolism gene	EIF5A	MTX1	0.814155103	4.15E-30
UCS	Cell metabolism gene	EIF5A	NOP56	0.816755088	1.94E-30
UCS	Cell metabolism gene	EIF5A	PSMB8	0.818639719	1.11E-30
UCS	Cell metabolism gene	EIF5A	SEC61B	0.820987855	5.45E-31
UCS	Cell metabolism gene	EIF5A	PGLS	0.821183489	5.14E-31
UCS	Cell metabolism gene	EIF5A	TIMM10	0.822496397	3.44E-31
UCS	Cell metabolism gene	EIF5A	SLC27A5	0.822779142	3.16E-31
UCS	Cell metabolism gene	EIF5A	WBSCR22	0.823964696	2.19E-31
UCS	Cell metabolism gene	EIF5A	NT5M	0.824110732	2.10E-31
UCS	Cell metabolism gene	EIF5A	GALK1	0.825337781	1.43E-31
UCS	Cell metabolism gene	EIF5A	NME1	0.825526931	1.35E-31
UCS	Cell metabolism gene	EIF5A	PSME1	0.829738676	3.56E-32
UCS	Cell metabolism gene	EIF5A	LSM2	0.830343599	2.93E-32
UCS	Cell metabolism gene	EIF5A	PSMD4	0.8306033	2.69E-32
UCS	Cell metabolism gene	EIF5A	TIMM50	0.831160237	2.25E-32
UCS	Cell metabolism gene	EIF5A	GEMIN6	0.832228357	1.59E-32
UCS	Cell metabolism gene	EIF5A	AAAS	0.832952637	1.26E-32
UCS	Cell metabolism gene	EIF5A	ACOT8	0.834748977	6.94E-33
UCS	Cell metabolism gene	EIF5A	PGP	0.835660334	5.13E-33
UCS	Cell metabolism gene	EIF5A	NANS	0.836575149	3.78E-33
UCS	Cell metabolism gene	EIF5A	ITPA	0.837723695	2.56E-33
UCS	Cell metabolism gene	EIF5A	SNRPB	0.839173615	1.57E-33
UCS	Cell metabolism gene	EIF5A	APRT	0.839555797	1.37E-33
UCS	Cell metabolism gene	EIF5A	EXOSC1	0.840664757	9.39E-34
UCS	Cell metabolism gene	EIF5A	TIMM13	0.842600523	4.79E-34
UCS	Cell metabolism gene	EIF5A	TOMM5	0.846535546	1.19E-34
UCS	Cell metabolism gene	EIF5A	EXOSC4	0.84710426	9.67E-35
UCS	Cell metabolism gene	EIF5A	EXOSC5	0.847728478	7.71E-35
UCS	Cell metabolism gene	EIF5A	PSMB7	0.847916942	7.20E-35
UCS	Cell metabolism gene	EIF5A	HMBS	0.84941439	4.17E-35
UCS	Cell metabolism gene	EIF5A	GEMIN7	0.849881648	3.51E-35
UCS	Cell metabolism gene	EIF5A	PSMB10	0.850285528	3.02E-35
UCS	Cell metabolism gene	EIF5A	DGKZ	0.85227433	1.44E-35
UCS	Cell metabolism gene	EIF5A	EBP	0.853178566	1.03E-35
UCS	Cell metabolism gene	EIF5A	POLR3K	0.853483715	9.15E-36
UCS	Cell metabolism gene	EIF5A	PSMC3	0.857209703	2.19E-36
UCS	Cell metabolism gene	EIF5A	SNRPD1	0.857813285	1.73E-36
UCS	Cell metabolism gene	EIF5A	PSMD13	0.860999656	4.91E-37
UCS	Cell metabolism gene	EIF5A	SNRPD2	0.862594533	2.58E-37
UCS	Cell metabolism gene	EIF5A	PAFAH1B3	0.86326618	1.96E-37
UCS	Cell metabolism gene	EIF5A	TIMM17B	0.865521693	7.76E-38
UCS	Cell metabolism gene	EIF5A	POLR2H	0.86564624	7.37E-38
UCS	Cell metabolism gene	EIF5A	TSTA3	0.865932046	6.55E-38
UCS	Cell metabolism gene	EIF5A	SNRPF	0.866443886	5.29E-38
UCS	Cell metabolism gene	EIF5A	SRM	0.868091091	2.64E-38
UCS	Cell metabolism gene	EIF5A	DGUOK	0.869356061	1.54E-38
UCS	Cell metabolism gene	EIF5A	PHKG2	0.8716508	5.72E-39
UCS	Cell metabolism gene	EIF5A	GUK1	0.871993995	4.92E-39
UCS	Cell metabolism gene	EIF5A	PSMB6	0.87261785	3.74E-39
UCS	Cell metabolism gene	EIF5A	TOMM40	0.875291313	1.14E-39
UCS	Cell metabolism gene	EIF5A	TIMM8B	0.877016975	5.20E-40
UCS	Cell metabolism gene	EIF5A	DTYMK	0.877724906	3.76E-40
UCS	Cell metabolism gene	EIF5A	PSMA4	0.881633432	6.04E-41
UCS	Cell metabolism gene	EIF5A	PSMB3	0.884871683	1.26E-41
UCS	Cell metabolism gene	EIF5A	TBCB	0.899500053	5.69E-45
UCS	Cell metabolism gene	EIF5A	LSM4	0.900325989	3.55E-45
UCS	CGC	EIF5A	RECQL4	0.825900739	1.20E-31
UCS	CGC	EIF5A	COX6C	0.831581517	1.96E-32
UCS	CGC	EIF5A	TFPT	0.837247967	3.01E-33
UCS	CGC	EIF5A	SDHAF2	0.843168267	3.93E-34
UCS	Epifactor	EIF5A	HIST2H2AC	0.800298835	1.99E-28
UCS	Epifactor	EIF5A	PRPF31	0.805029372	5.51E-29
UCS	Epifactor	EIF5A	CXXC1	0.806395147	3.77E-29
UCS	Epifactor	EIF5A	MAZ	0.807983889	2.42E-29
UCS	Epifactor	EIF5A	INO80E	0.809905043	1.41E-29
UCS	Epifactor	EIF5A	RBX1	0.81119678	9.75E-30
UCS	Epifactor	EIF5A	CDK5	0.81298802	5.83E-30
UCS	Epifactor	EIF5A	PRMT1	0.817531881	1.54E-30
UCS	Epifactor	EIF5A	SIRT7	0.820068453	7.20E-31
UCS	Epifactor	EIF5A	ZNHIT1	0.825498101	1.36E-31
UCS	Epifactor	EIF5A	ZGPAT	0.829077417	4.40E-32
UCS	Epifactor	EIF5A	PRR14	0.832924094	1.27E-32
UCS	Epifactor	EIF5A	TFPT	0.837247967	3.01E-33
UCS	Epifactor	EIF5A	EXOSC1	0.840664757	9.39E-34
UCS	Epifactor	EIF5A	EXOSC4	0.84710426	9.67E-35
UCS	Epifactor	EIF5A	PPM1G	0.84748518	8.42E-35
UCS	Epifactor	EIF5A	EXOSC5	0.847728478	7.71E-35
UCS	Epifactor	EIF5A	NAP1L4	0.849338844	4.29E-35
UCS	Epifactor	EIF5A	RUVBL2	0.858594921	1.27E-36
UCS	Epifactor	EIF5A	BRMS1	0.858700399	1.22E-36
UCS	Epifactor	EIF5A	SIRT6	0.865295799	8.53E-38
UCS	Epifactor	EIF5A	PPP4C	0.883420869	2.56E-41
UCS	Epifactor	EIF5A	C17orf49	0.883591591	2.36E-41
UCS	Epifactor	EIF5A	TAF10	0.891298785	4.90E-43
UCS	IUPHAR	EIF5A	CDK5	0.81298802	5.83E-30
UCS	IUPHAR	EIF5A	RNPEPL1	0.813045416	5.73E-30
UCS	IUPHAR	EIF5A	FKBP1A	0.813865818	4.52E-30
UCS	IUPHAR	EIF5A	ECE2	0.814141591	4.17E-30
UCS	IUPHAR	EIF5A	DYRK4	0.814371148	3.90E-30
UCS	IUPHAR	EIF5A	TOP1MT	0.814390471	3.88E-30
UCS	IUPHAR	EIF5A	PRMT1	0.817531881	1.54E-30
UCS	IUPHAR	EIF5A	PSMB8	0.818639719	1.11E-30
UCS	IUPHAR	EIF5A	DPP7	0.819735474	7.96E-31
UCS	IUPHAR	EIF5A	SIRT7	0.820068453	7.20E-31
UCS	IUPHAR	EIF5A	SLC27A5	0.822779142	3.16E-31
UCS	IUPHAR	EIF5A	NT5M	0.824110732	2.10E-31
UCS	IUPHAR	EIF5A	PPIA	0.845326295	1.83E-34
UCS	IUPHAR	EIF5A	SIRT6	0.865295799	8.53E-38
UCS	IUPHAR	EIF5A	MPDU1	0.8714833	6.15E-39
UCS	IUPHAR	EIF5A	PHKG2	0.8716508	5.72E-39
UCS	IUPHAR	EIF5A	PSMB6	0.87261785	3.74E-39
UCS	Kinase	EIF5A	CDK5	0.81298802	5.83E-30
UCS	Kinase	EIF5A	DYRK4	0.814371148	3.90E-30
UCS	Kinase	EIF5A	PHKG2	0.8716508	5.72E-39
UCS	TF	EIF5A	PIN1	0.803920596	7.47E-29
UCS	TF	EIF5A	IRF3	0.804322633	6.69E-29
UCS	TF	EIF5A	CXXC1	0.806395147	3.77E-29
UCS	TF	EIF5A	GLI4	0.80653578	3.63E-29
UCS	TF	EIF5A	ZNF444	0.806809104	3.36E-29
UCS	TF	EIF5A	MAZ	0.807983889	2.42E-29
UCS	TF	EIF5A	THYN1	0.809973443	1.38E-29
UCS	TF	EIF5A	ZNF428	0.817727884	1.45E-30
UCS	TF	EIF5A	SNAPC2	0.818051859	1.32E-30
UCS	TF	EIF5A	USF1	0.828651214	5.04E-32
UCS	TF	EIF5A	ZGPAT	0.829077417	4.40E-32
UCS	TF	EIF5A	ZNF787	0.830352554	2.92E-32
UCS	TF	EIF5A	ZNF511	0.842095802	5.71E-34
UCS	TF	EIF5A	DRAP1	0.849014315	4.83E-35
UCS	TF	EIF5A	GTF3A	0.852535368	1.31E-35
UCS	TF	EIF5A	ZNF688	0.854311471	6.68E-36
UCS	TF	EIF5A	ZNF668	0.889779771	1.08E-42
UCS	TSG	EIF5A	PIN1	0.803920596	7.47E-29
UCS	TSG	EIF5A	TSSC4	0.804021902	7.26E-29
UCS	TSG	EIF5A	IRF3	0.804322633	6.69E-29
UCS	TSG	EIF5A	AIP	0.806698737	3.47E-29
UCS	TSG	EIF5A	GADD45GIP1	0.809234249	1.70E-29
UCS	TSG	EIF5A	ST20	0.809888041	1.42E-29
UCS	TSG	EIF5A	PYCARD	0.815370891	2.91E-30
UCS	TSG	EIF5A	GABARAP	0.820089452	7.16E-31
UCS	TSG	EIF5A	NME1	0.825526931	1.35E-31
UCS	TSG	EIF5A	BRMS1	0.858700399	1.22E-36
UCS	TSG	EIF5A	SIRT6	0.865295799	8.53E-38
UCS	TSG	EIF5A	ZNF668	0.889779771	1.08E-42
UCS	TSG	EIF5A	PFN1	0.907896398	3.91E-47
UVM	Cell metabolism gene	EIF5A	SCO2	0.829982928	1.81E-21
UVM	Cell metabolism gene	EIF5A	MTX1	0.84326744	9.90E-23
UVM	Cell metabolism gene	EIF5A	PSMB6	0.852542057	1.10E-23
UVM	Epifactor	EIF5A	RUVBL2	0.807935766	1.35E-19
UVM	IUPHAR	EIF5A	MPDU1	0.838033489	3.21E-22
UVM	IUPHAR	EIF5A	PSMB6	0.852542057	1.10E-23
UVM	TSG	EIF5A	PFN1	0.92313371	4.06E-34

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	EIF5A	RPL38	-1.66722943744988	0.000257795914027732
BLCA	EIF5A	RPL5	-3.50581551367555	0.00026702880859375
HNSC	EIF5A	EEF2	-1.90805330069302	0.000299885096865183
STAD	EIF5A	RPL5	2.24361928856279	0.000433447770774365
LUSC	EIF5A	RPL38	-2.00110253296947	0.00049723236196648
THCA	EIF5A	EEF2	1.35574858496176	0.000711089919756285
PRAD	EIF5A	EEF1G	1.04301780897756	0.00116785923777763
THCA	EIF5A	DHPS	-2.2143641551526	0.00180184141035168
PRAD	EIF5A	EIF5A2	1.76773292297344	0.00192930085721699
COAD	EIF5A	EEF2	1.67025113686866	0.00197160243988037
ESCA	EIF5A	RPL15	1.76629417535644	0.0048828125
KICH	EIF5A	EIF5A2	2.29158986097535	0.00507164001464844
STAD	EIF5A	EEF2	-1.87846190344448	0.00733334058895707
LUAD	EIF5A	EIF5A2	-2.4963976518052	0.00773628245812536
THCA	EIF5A	DOHH	-1.77397594528087	0.0113302146920605
ESCA	EIF5A	EEF2	-3.4598326417414	0.0185546875
KICH	EIF5A	RPL5	1.79380241489629	0.0219083428382874
PRAD	EIF5A	DOHH	-1.36546815787639	0.0278551491578459
READ	EIF5A	DOHH	-2.91730296765426	0.03125
PRAD	EIF5A	RPL38	-1.37307294389303	0.0319785302138518
KIRP	EIF5A	EEF1G	-2.05417074227368	0.0375871751457453
BRCA	EIF5A	DHPS	-1.35684185337444	1.3885583420074e-06
THCA	EIF5A	EIF5A2	1.86994054726467	1.93116089157046e-10
BRCA	EIF5A	RPL9	-3.0134495932037	2.59559089925671e-05
KIRC	EIF5A	RPL38	-2.47198269993031	2.66680331214666e-11
PRAD	EIF5A	EEF2	1.63926479894191	2.70126293247147e-08
PRAD	EIF5A	DHPS	1.82553075697225	4.6388445697259e-07
KIRP	EIF5A	RPL38	-2.05925877790715	4.97791916131974e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF5A

RPL5, XPO1, Pds5a, Csnk1e, VHL, ELAVL1, TCF3, CUL2, COPS5, XPO4, DDX17, MACF1, VAPA, ATP5B, VCP, ATF2, IQCB1, NPM1, XRN2, BCCIP, GDA, GNS, MVD, PEPD, TYMS, WDR1, GLS, HSPD1, STUB1, DCP2, HUWE1, CRX, DHPS, MEOX2, REL, CUL7, ESR1, DOHH, EWSR1, SOD1, CHST15, FAM134A, Nedd1, Smc3, Racgap1, MCM2, U2AF2, EIF2S2, CDH1, DUSP12, DUSP13, DUSP19, DUSP2, DUSP26, DLST, DNM1L, SOAT1, FOXA1, CCND2, UBE2A, CFTR, PTPN2, PTPN3, DUSP7, TENC1, PPTC7, PHOSPHO1, UBE2M, EFTUD2, AAR2, TNIP2, PRKCZ, ESR2, HEXIM1, AGR2, RECQL4, METTL14, KIAA1429, ATG16L1, ACTC1, PHB, NR2C2, BICD2, RPS6, RPL10A, RPL23A, EYA4, BIRC3, PARK2, LRRK2, GSC2, PICK1, SDCBP, LBX1, MEI4, PLEKHA4, ORF50, GAB2, SH3GL3, CHMP4C, PRNP, SUMO2, NDN, Rnf183, RBM45, BRD4, LGALS9, NONO, TOP1, SFPQ, PSPC1, NUDT21, DDX42, SART1, PPIL4, NUFIP2, RPS19, CPSF7, PPP1R10, MEPCE, NSRP1, NDC80, SP100, CTTN, TDRKH, FAM76B, METTL17, GLUD1, ATXN2L, YY1, PRPF4B, KDM4C, CCNT1, RPSA, FIP1L1, SPIN1, HMGB2, PDIA6, LRPAP1, LMNA, PRPF40A, WDR82, CPSF6, RBM25, UFL1, DDRGK1, FZR1, WDR5, EIF5A2, BTF3, nsp13, nsp14, nsp16, nsp4, nsp8, OPTN,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF5A	chr17	7213031	G	C	single_nucleotide_variant	Likely_pathogenic	Neurodevelopmental_disorder	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF5A	chr17	7213097	C	A	single_nucleotide_variant	Pathogenic	FAUNDES-BANKA_SYNDROME	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF5A	chr17	7214327	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF5A	chr17	7214721	T	TA	Duplication	Pathogenic	FAUNDES-BANKA_SYNDROME	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
EIF5A	chr17	7214723	C	G	single_nucleotide_variant	Pathogenic	FAUNDES-BANKA_SYNDROME	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF5A	chr17	7214723	C	T	single_nucleotide_variant	Pathogenic	FAUNDES-BANKA_SYNDROME	SO:0001587\|nonsense	SO:0001587\|nonsense
EIF5A	chr17	7214741	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF5A	chr17	7214893	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF5A	CESC	chr17	7213030	7213030	C	T	Missense_Mutation		4
EIF5A	CESC	chr17	7214824	7214824	C	T	Silent		3
EIF5A	CESC	chr17	7213022	7213022	C	T	Missense_Mutation		3
EIF5A	UCEC	chr17	7212941	7212941	C	T	Missense_Mutation	p.S26L	2
EIF5A	BLCA	chr17	7212983	7212983	G	A	Missense_Mutation	p.G10E	2
EIF5A	UCEC	chr17	7212975	7212975	C	T	Silent	p.F37	2
EIF5A	BLCA	chr17	7213108	7213108	G	A	Missense_Mutation	p.G52S	2
EIF5A	UCEC	chr17	7213091	7213091	C	T	Missense_Mutation	p.S76L	2
EIF5A	UCEC	chr17	7214392	7214392	C	T	Missense_Mutation	p.P104L	2
EIF5A	UCEC	chr17	7214735	7214735	C	T	Missense_Mutation	p.R143C	2
EIF5A	UCEC	chr17	7214946	7214946	C	T	Missense_Mutation	p.A181V	2
EIF5A	CESC	chr17	7213030	7213030	C	T	Missense_Mutation	p.R26C	2
EIF5A	UVM	chr17	7213113	7213113	C	T	Silent		2
EIF5A	SKCM	chr17	7213002	7213002	C	T	Silent	p.A16A	2
EIF5A	UVM	chr17	7213113	7213113	C	T	Silent	p.H53H	2
EIF5A	BLCA	chr17	7214697	7214697	C	A	Nonsense_Mutation	p.S100*	2
EIF5A	SKCM	chr17	7212975	7212975	C	T	Silent	p.F7F	2
EIF5A	LIHC	chr17	7214414	7214414	C	-	Frame_Shift_Del	p.V81fs	1
EIF5A	BLCA	chr17	7214768	7214768	G	C	Missense_Mutation	p.E124Q	1
EIF5A	STAD	chr17	7214775	7214775	A	C	Missense_Mutation	p.K156T	1
EIF5A	HNSC	chr17	7214723	7214723	C	T	Nonsense_Mutation	p.R109*	1
EIF5A	LIHC	chr17	7214824	7214824	C	-	Frame_Shift_Del	p.F142fs	1
EIF5A	STAD	chr17	7214949	7214949	T	C	Missense_Mutation	p.M182T	1
EIF5A	HNSC	chr17	7213022	7213022	C	T	Missense_Mutation	p.S23L	1
EIF5A	LUAD	chr17	7214941	7214941	C	G	Missense_Mutation	p.I149M	1
EIF5A	STAD	chr17	7214674	7214674	T	C	Silent	p.I122I	1
EIF5A	HNSC	chr17	7214726	7214726	G	A	Missense_Mutation	p.E110K	1
EIF5A	LUAD	chr17	7214920	7214921	AG	-	Frame_Shift_Del	p.TE142fs	1
EIF5A	STAD	chr17	7214674	7214674	T	C	Silent	p.I92I	1
EIF5A	HNSC	chr17	7214764	7214764	G	C	Missense_Mutation	p.E122D	1
EIF5A	BLCA	chr17	7214857	7214857	G	A	Silent		1
EIF5A	PRAD	chr17	7214356	7214356	A	T	Missense_Mutation	p.D62V	1
EIF5A	STAD	chr17	7213109	7213109	G	A	Missense_Mutation	p.G52D	1
EIF5A	KIRC	chr17	7214802	7214802	T	C	Splice_Site	.	1
EIF5A	BLCA	chr17	7214921	7214921	G	A	Missense_Mutation		1
EIF5A	PRAD	chr17	7214340	7214340	C	T	Missense_Mutation	p.H57Y	1
EIF5A	STAD	chr17	7212989	7212989	C	T	Missense_Mutation	p.A12V	1
EIF5A	KIRC	chr17	7214802	7214802	T	C	Missense_Mutation	p.V135A	1
EIF5A	BLCA	chr17	7214768	7214768	G	C	Missense_Mutation		1
EIF5A	SARC	chr17	7212926	7212926	G	T	Missense_Mutation		1
EIF5A	STAD	chr17	7214949	7214949	T	C	Missense_Mutation	p.M152T	1
EIF5A	LIHC	chr17	7213092	7213092	G	T	Silent		1
EIF5A	BLCA	chr17	7212983	7212983	G	A	Missense_Mutation		1
EIF5A	SARC	chr17	7211876	7211876	G	T	Missense_Mutation		1
EIF5A	CESC	chr17	7213022	7213022	C	T	Missense_Mutation	p.S53L	1
EIF5A	STAD	chr17	7214775	7214775	A	C	Missense_Mutation	p.K126T	1
EIF5A	LIHC	chr17	7212975	7212975	C	G	Missense_Mutation	p.F37L	1
EIF5A	UVM	chr17	7213113	7213113	C	T	Silent	p.H83H	1
EIF5A	BLCA	chr17	7213108	7213108	G	A	Missense_Mutation		1
EIF5A	COAD	chr17	7214927	7214927	G	C	Missense_Mutation	p.A145P	1
EIF5A	STAD	chr17	7214736	7214736	G	A	Missense_Mutation	p.R113H	1
EIF5A	LIHC	chr17	7213030	7213030	C	T	Missense_Mutation	p.R56C	1
EIF5A	SKCM	chr17	7215142	7215142	G	A	Splice_Site	.	1
EIF5A	HNSC	chr17	7214726	7214726	G	A	Missense_Mutation		1
EIF5A	UCEC	chr17	7214942	7214942	A	G	Missense_Mutation	p.K150E	1
EIF5A	LIHC	chr17	7212998	7212998	C	G	Nonsense_Mutation	p.S15*	1
EIF5A	BLCA	chr17	7214921	7214921	G	A	Missense_Mutation	p.E143K	1
EIF5A	HNSC	chr17	7214764	7214764	G	C	Missense_Mutation		1
EIF5A	UCEC	chr17	7214946	7214946	C	T	Missense_Mutation	p.A151V	1

Copy number variation (CNV) of EIF5A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF5A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
93149	ACC	TCGA-OR-A5KY-01A	ALDH3A2	chr17	19575269	+	EIF5A	chr17	7212934	+
88497	N/A	BM720324	EIF5A	chr17	7215633	+	ADAR	chr1	154555244	-
99197	COAD	TCGA-AZ-4616-01A	EIF5A	chr17	7214970	+	COX4I1	chr16	85840344	+
87422	STAD	TCGA-BR-A4PD-01A	EIF5A	chr17	7214958	+	COX8A	chr11	63743883	+
96603	N/A	CN340509	EIF5A	chr17	7213009	+	DNAJC24	chr11	31391414	+
26087	UCEC	TCGA-BS-A0TE-01A	EIF5A	chr17	7210971	+	FTH1P10	chr5	17354560	-
76679	LUSC	TCGA-66-2800-01A	EIF5A	chr17	7213119	+	MKS1	chr17	56285944	-
62193	PRAD	TCGA-KC-A7FD	EIF5A	chr17	7214970	+	MRPL39	chr21	26969726	-
94360	N/A	BG255468	EIF5A	chr17	7214368	+	RALY	chr20	32602679	+
99653	N/A	CN336887	EIF5A	chr17	7215318	+	SGSM3	chr22	40800416	+
94379	N/A	EC579466	EIF5A	chr17	7212523	+	SH3GLB2	chr9	131770794	-
93149	N/A	CN372949	FKBP4	chr12	2904351	+	EIF5A	chr17	7211044	+
93149	CHOL	TCGA-W5-AA31-01A	GLOD4	chr17	673109	-	EIF5A	chr17	7212934	+
93149	STAD	TCGA-HU-A4G6	LYZ	chr12	69742324	+	EIF5A	chr17	7215140	+
93149	Non-Cancer	ERR315404	PIK3R5	chr17	8868913	-	EIF5A	chr17	7212934	+
93149	THCA	TCGA-KS-A4I3	RAI1	chr17	17627473	+	EIF5A	chr17	7212933	+
93149	OV	TCGA-20-1686-01A	RPH3AL	chr17	65445	-	EIF5A	chr17	7212934	+
93149	N/A	BF883338	TCOF1	chr5	149778618	+	EIF5A	chr17	7213103	+
93153	PRAD	TCGA-J4-A67N-01A	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
LIHC	EIF5A	1.13230195648719	0.12425269022402	0.00535644221876944	0.00468203103948678	0.00523873485304453	417
LIHC	EIF5A	1.13230195648719	0.12425269022402	0.00535644221876944	0.00468203103948678	0.00523873485304453	417
BLCA	EIF5A	1.13325336369204	0.125092579016233	0.0064415625369676	0.00520490453165866	0.00639869689420437	422
KICH	EIF5A	2.04002800171824	0.712963534094392	0.019334266964134	0.0109699189775157	0.0231690955114062	89
MESO	EIF5A	1.41282880819556	0.345593941511565	0.0328731368491657	0.0328907906324156	0.0334285675239763	85
MESO	EIF5A	1.41282880819556	0.345593941511565	0.0328731368491657	0.0328907906324156	0.0334285675239763	85

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	EIF5A	0.00251243818740204	0.07
STAD	EIF5A	0.00417555221900783	0.11
KIRP	EIF5A	0.00465663351525175	0.12
SKCM	EIF5A	0.00748409828490121	0.19
SARC	EIF5A	0.00761049966104038	0.19

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	EIF5A	0.0343767645113769	1
PAAD	EIF5A	0.0320985118322954	1
SARC	EIF5A	0.000296362003834382	0.0098

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0022548	Keloid	1	CTD_human
C0205696	Anaplastic carcinoma	1	CTD_human
C0205697	Carcinoma, Spindle-Cell	1	CTD_human
C0205698	Undifferentiated carcinoma	1	CTD_human
C1257925	Mammary Carcinoma, Animal	1	CTD_human