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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RBM24 (NCBI Gene ID:221662)

Gene Summary

Gene Summary

Gene Information	Gene Name: RBM24
	Gene ID: 221662
	Gene Symbol	RBM24
	Gene ID	221662
	Gene Name	RNA binding motif protein 24
	Synonyms	RNPC6\|dJ259A10.1
	Cytomap	6p22.3
	Type of Gene	protein-coding
	Description	RNA-binding protein 24RNA-binding region (RNP1, RRM) containing 6RNA-binding region-containing protein 6
	Modification date	20200313
	UniProtAcc	Q9BX46

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RBM24	GO:0061158	3'-UTR-mediated mRNA destabilization	24375645

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RBM24	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'RBM24[title] AND translation [title] AND human.'

Gene	Title	PMID
RBM24	RBM24 stabilizes hepatitis B virus pregenomic RNA but inhibits core protein translation by targeting the terminal redundancy sequence	29760415

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	RBM24	1.65442071880919	0.000224528839221527
UCEC	RBM24	-2.23655380194261	0.015625
HNSC	RBM24	-1.60068400196876	0.049041343804447
LIHC	RBM24	3.57564165825458	7.57892378533037e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	RBM24	hsa-miR-125b-5p	95	-0.336702457144448	0.0206576919519927

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
OV	RBM24	1	2	0.0169427339748412	0.190235185185185	0.270535380909365	0.653034687172535	0.500261798371471

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
PRAD	RBM24	3	2	0.00127112092928488	0.669659741248097	0.552168705941591	0.336503713577114	0.124176330112098

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LIHC	RBM24	-0.042719553	0.024266608

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RBM24 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
HNSC	Cell metabolism gene	RBM24	CKMT2	0.81080779	2.65E-133
HNSC	Cell metabolism gene	RBM24	CKM	0.821743067	7.30E-140
HNSC	Cell metabolism gene	RBM24	ANKRD1	0.833420194	2.20E-147
HNSC	CGC	RBM24	MYOD1	0.811498772	1.05E-133
HNSC	Epifactor	RBM24	PRKAG3	0.835698018	6.41E-149
HNSC	Epifactor	RBM24	APOBEC2	0.842536432	1.13E-153
HNSC	Epifactor	RBM24	SMYD1	0.865004489	4.68E-171
HNSC	IUPHAR	RBM24	CHRNA1	0.807985424	1.12E-131
HNSC	IUPHAR	RBM24	NPY6R	0.809834452	9.70E-133
HNSC	IUPHAR	RBM24	CHRNG	0.820336632	5.40E-139
HNSC	IUPHAR	RBM24	SCN4A	0.830306737	2.53E-145
HNSC	IUPHAR	RBM24	ATP1A2	0.832417998	1.02E-146
HNSC	IUPHAR	RBM24	TTN	0.833698788	1.43E-147
HNSC	IUPHAR	RBM24	PRKAG3	0.835698018	6.41E-149
HNSC	IUPHAR	RBM24	CHRND	0.853769274	5.33E-162
HNSC	IUPHAR	RBM24	CACNA1S	0.864417864	1.46E-170
HNSC	Kinase	RBM24	TTN	0.833698788	1.43E-147
HNSC	TF	RBM24	MYOD1	0.811498772	1.05E-133
HNSC	TF	RBM24	MYOG	0.835521725	8.45E-149
HNSC	TF	RBM24	MYF6	0.862525232	5.47E-169
HNSC	TSG	RBM24	FHL1	0.804550171	9.73E-130
HNSC	TSG	RBM24	DUSP26	0.806751699	5.61E-131
HNSC	TSG	RBM24	HSPB7	0.86005539	5.72E-167
KICH	IUPHAR	RBM24	ATP10A	0.808566723	3.29E-22
KICH	IUPHAR	RBM24	MRGPRF	0.820090635	2.72E-23
TGCT	Cell metabolism gene	RBM24	MTMR3	0.817240341	1.08E-38
TGCT	Cell metabolism gene	RBM24	B3GAT2	0.827395969	2.01E-40
TGCT	CGC	RBM24	PRDM1	0.80734181	4.17E-37
TGCT	Epifactor	RBM24	PRDM1	0.80734181	4.17E-37
TGCT	Epifactor	RBM24	UHRF2	0.834871383	9.01E-42
TGCT	Epifactor	RBM24	BMI1	0.879844968	1.29E-51
TGCT	IUPHAR	RBM24	SLC5A7	0.807513399	3.92E-37
TGCT	IUPHAR	RBM24	ACVR1B	0.830071711	6.72E-41
TGCT	Kinase	RBM24	ACVR1B	0.830071711	6.72E-41
TGCT	TF	RBM24	ZFP30	0.801260906	3.54E-36
TGCT	TF	RBM24	ZNF304	0.804693982	1.07E-36
TGCT	TF	RBM24	ZNF345	0.805098132	9.26E-37
TGCT	TF	RBM24	PRDM1	0.80734181	4.17E-37
TGCT	TF	RBM24	SOX17	0.810526548	1.32E-37
TGCT	TF	RBM24	ZNF2	0.821866926	1.81E-39
TGCT	TF	RBM24	ZNF548	0.841838703	4.33E-43
TGCT	TF	RBM24	ZNF781	0.853100768	2.31E-45
TGCT	TF	RBM24	ZNF518B	0.859292894	1.08E-46
TGCT	TSG	RBM24	KANK1	0.803123374	1.85E-36
TGCT	TSG	RBM24	PRDM1	0.80734181	4.17E-37
TGCT	TSG	RBM24	NRCAM	0.8162525	1.57E-38
TGCT	TSG	RBM24	UHRF2	0.834871383	9.01E-42

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
ESCA	RBM24	RBM42	-1.16407050073883	0.0009765625
LUAD	RBM24	CELF1	-2.27949736131754	0.0118606607155675
COAD	RBM24	SF1	-4.15611836563102	0.0176135301589966
READ	RBM24	SF1	-4.06236226767122	0.03125
LUAD	RBM24	RBM42	-1.122142531126	0.0417265102143948
BLCA	RBM24	SF1	-2.17267387315221	0.0493659973144531
BLCA	RBM24	RBPMS2	-9.19886836304731	1.1444091796875e-05
BRCA	RBM24	RBM20	-1.93319029427805	1.28234576273742e-12
STAD	RBM24	RBPMS2	-2.4464031312502	1.49570405483246e-06
KIRP	RBM24	RBPMS2	-2.35527114075536	1.60322524607182e-05
LUSC	RBM24	RBM42	-5.46633676984415	1.95811408544885e-05
THCA	RBM24	SF1	-9.3346192550436	2.943362132749e-05
PRAD	RBM24	EPB41	1.72202637982275	4.09008451860611e-08
THCA	RBM24	RBM20	-1.80564303968356	6.25847760426763e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RBM24

RBFOX1, EPPK1, JUP, SERPINB13, CALML5, H2AFY, TRIM29, IGHG2, IGHG1, RBM38, LGALS7B, CALML3, SERPINB5, PKP1, IVL, ANKRD40, SERPINB2, CRYAB, EVPL, PKP3, PPL, TYMP, PLCD1, DMKN, QSOX1, SERPINB3, POU2AF1, RBPMS, DAZAP2, UBQLN2, C10orf55, DUX4L9, CREBBP, PIK3IP1, SS18L2,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RBM24	KIRC	chr6	17292140	17292140	C	T	Silent	p.A167A	5
RBM24	BRCA	chr6	17292294	17292294	G	A	Missense_Mutation	p.A219T	4
RBM24	KIRP	chr6	17292212	17292212	G	A	Silent	p.G191G	4
RBM24	STAD	chr6	17292146	17292146	C	T	Silent	p.A169A	3
RBM24	ESCA	chr6	17292011	17292011	G	T	Silent	p.P124P	3
RBM24	LUAD	chr6	17292081	17292081	C	A	Missense_Mutation	p.P148T	3
RBM24	PAAD	chr6	17283114	17283114	G	A	Missense_Mutation	p.V83M	3
RBM24	BRCA	chr6	17283067	17283067	G	C	Missense_Mutation	p.R67T	3
RBM24	STAD	chr6	17292143	17292143	C	T	Silent	p.A168A	2
RBM24	CESC	chr6	17292245	17292245	C	T	Silent		2
RBM24	LUAD	chr6	17292055	17292055	C	A	Missense_Mutation	p.P139Q	2
RBM24	STAD	chr6	17292068	17292068	C	T	Silent	p.A143A	2
RBM24	LUAD	chr6	17292138	17292138	G	A	Missense_Mutation	p.A167T	2
RBM24	HNSC	chr6	17291995	17291995	C	T	Missense_Mutation	p.A119V	2
RBM24	LUAD	chr6	17283081	17283081	C	A	Missense_Mutation	p.P72T	2
RBM24	SARC	chr6	17292011	17292011	G	T	Silent		2
RBM24	STAD	chr6	17292264	17292264	G	T	Missense_Mutation	p.A209S	2
RBM24	LUAD	chr6	17292285	17292285	G	T	Missense_Mutation	p.A216S	2
RBM24	STAD	chr6	17292117	17292117	T	C	Missense_Mutation	p.Y160H	2
RBM24	ESCA	chr6	17292449	17292449	A	-	RNA	NULL	2
RBM24	STAD	chr6	17292179	17292179	C	A	Silent	p.A180A	2
RBM24	UCEC	chr6	17281911	17281911	C	A	Silent	p.V33	2
RBM24	UCEC	chr6	17292140	17292140	C	T	Silent	p.P132L	2
RBM24	BRCA	chr6	17292010	17292010	C	T	Missense_Mutation	p.P124L	2
RBM24	LIHC	chr6	17281858	17281858	G	-	Frame_Shift_Del	p.G17fs	2
RBM24	STAD	chr6	17292149	17292149	T	C	Silent	p.A170A	2
RBM24	UCEC	chr6	17292146	17292146	C	T	Silent	p.P134L	2
RBM24	ESCA	chr6	17292224	17292224	C	T	Silent		2
RBM24	LIHC	chr6	17284896	17284896	T	-	Frame_Shift_Del	p.F101fs	1
RBM24	PAAD	chr6	17292038	17292038	C	G	Silent	p.V133V	1
RBM24	SKCM	chr6	17292009	17292009	C	T	Missense_Mutation	p.P124S	1
RBM24	LIHC	chr6	17292029	17292029	G	-	Frame_Shift_Del	p.P130fs	1
RBM24	PAAD	chr6	17283114	17283114	G	A	Missense_Mutation		1
RBM24	ESCA	chr6	17292224	17292224	C	T	Silent	p.Y195Y	1
RBM24	SKCM	chr6	17291987	17291987	G	A	Splice_Site	p.G116_splice	1
RBM24	COAD	chr6	17292140	17292140	C	T	Silent	p.A122A	1
RBM24	PCPG	chr6	17283076	17283076	A	T	Missense_Mutation	p.K70M	1
RBM24	HNSC	chr6	17291995	17291995	C	T	Missense_Mutation		1
RBM24	SKCM	chr6	17283149	17283149	C	T	Silent	p.I94I	1
RBM24	THYM	chr6	17292130	17292130	C	T	Missense_Mutation		1
RBM24	COAD	chr6	17292149	17292149	T	C	Silent	p.A125A	1
RBM24	READ	chr6	17284940	17284940	C	T	Silent	p.F70F	1
RBM24	HNSC	chr6	17292144	17292144	G	A	Missense_Mutation	p.A169T	1
RBM24	SKCM	chr6	17284914	17284914	C	T	Missense_Mutation	p.H107Y	1
RBM24	THYM	chr6	17281866	17281866	G	A	Silent		1
RBM24	ESCA	chr6	17283276	17283276	A	G	RNA	NULL	1
RBM24	SARC	chr6	17284893	17284893	G	T	Missense_Mutation		1
RBM24	STAD	chr6	17292264	17292264	G	T	Missense_Mutation		1
RBM24	THYM	chr6	17292130	17292130	C	T	Missense_Mutation	p.A164V	1
RBM24	ESCA	chr6	17291124	17291124	G	T	RNA	NULL	1
RBM24	ESCA	chr6	17292448	17292449	-	AAA	RNA	NULL	1
RBM24	SKCM	chr6	17292073	17292073	C	T	Missense_Mutation	p.S100F	1
RBM24	THYM	chr6	17281866	17281866	G	A	Silent	p.L18L	1
RBM24	LUAD	chr6	17292272	17292272	C	T	Silent	p.A211A	1
RBM24	SKCM	chr6	17292009	17292009	C	T	Missense_Mutation	p.P79S	1
RBM24	KIRP	chr6	17292212	17292212	G	A	Silent		1
RBM24	BLCA	chr6	17292231	17292231	C	T	Nonsense_Mutation	p.Q198*	1
RBM24	LUAD	chr6	17292270	17292270	G	A	Missense_Mutation	p.A211T	1
RBM24	ESCA	chr6	17292540	17292540	G	T	RNA	NULL	1
RBM24	SKCM	chr6	17291987	17291987	G	A	Silent	p.G71G	1
RBM24	LIHC	chr6	17281858	17281858	G	-	Frame_Shift_Del	p.V15fs	1
RBM24	STAD	chr6	17283113	17283113	C	T	Silent	p.N82N	1
RBM24	OV	chr6	17284942	17284942	G	A	Missense_Mutation	p.G71E	1
RBM24	ESCA	chr6	17292855	17292855	C	G	RNA	NULL	1
RBM24	SKCM	chr6	17292073	17292073	C	T	Missense_Mutation	p.S145F	1
RBM24	SKCM	chr6	17292259	17292259	G	A	Missense_Mutation	p.G207E	1

Copy number variation (CNV) of RBM24
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RBM24
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
24781	BRCA	TCGA-B6-A0I6-01A	CDKAL1	chr6	20955816	+	RBM24	chr6	17291987	+
24781	SARC	TCGA-IW-A3M4-01A	DST	chr6	56354288	-	RBM24	chr6	17291987	+
24783	OV	TCGA-25-2393-01A	E2F3	chr6	20404063	+	RBM24	chr6	17283036	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RBM24	0.000469267515286963	0.013
KIRC	RBM24	0.00140315319276969	0.036
KIRP	RBM24	0.00238643590428942	0.06
SARC	RBM24	0.00973303664880348	0.23
LAML	RBM24	0.0119772926982472	0.28
BLCA	RBM24	0.0211284102468715	0.46
PAAD	RBM24	0.0366902500725875	0.77
LIHC	RBM24	4.7118583950832e-08	1.3e-06

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PRAD	RBM24	0.00149173474369712	0.049
BLCA	RBM24	0.0311056544468953	0.96
SARC	RBM24	0.0213093552497233	0.68

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source