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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: METAP1 (NCBI Gene ID:23173)

Gene Summary

Gene Summary

Gene Information	Gene Name: METAP1
	Gene ID: 23173
	Gene Symbol	METAP1
	Gene ID	23173
	Gene Name	methionyl aminopeptidase 1
	Synonyms	MAP1A\|MetAP1A
	Cytomap	4q23
	Type of Gene	protein-coding
	Description	methionine aminopeptidase 1MAP 1metAP 1peptidase M 1
	Modification date	20200313
	UniProtAcc	P53582

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'METAP1[title] AND translation [title] AND human.'

Gene	Title	PMID
METAP1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000296411	99966329	99966461	In-frame
ENST00000296411	99969883	99970027	In-frame
ENST00000296411	99978903	99978969	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000296411	99966329	99966461	2808	790	921	386	218	262
ENST00000296411	99969883	99970027	2808	922	1065	386	262	310
ENST00000296411	99978903	99978969	2808	1066	1131	386	310	332

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P53582	262	310	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
P53582	218	262	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
P53582	310	332	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
P53582	218	262	220	220	Metal binding	Note=Divalent metal cation 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|HAMAP-Rule:MF_03174,ECO:0000269\|PubMed:16274222,ECO:0000269\|PubMed:16724298,ECO:0000269\|PubMed:16823043,ECO:0000269\|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
P53582	218	262	231	231	Metal binding	Note=Divalent metal cation 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|HAMAP-Rule:MF_03174,ECO:0000269\|PubMed:16274222,ECO:0000269\|PubMed:16724298,ECO:0000269\|PubMed:16823043,ECO:0000269\|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
P53582	218	262	231	231	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|HAMAP-Rule:MF_03174,ECO:0000269\|PubMed:16274222,ECO:0000269\|PubMed:16724298,ECO:0000269\|PubMed:16823043,ECO:0000269\|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
P53582	262	310	294	294	Metal binding	Note=Divalent metal cation 2%3B catalytic%3B via tele nitrogen;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|HAMAP-Rule:MF_03174,ECO:0000269\|PubMed:16274222,ECO:0000269\|PubMed:16724298,ECO:0000269\|PubMed:16823043,ECO:0000269\|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
P53582	310	332	327	327	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|HAMAP-Rule:MF_03174,ECO:0000269\|PubMed:16274222,ECO:0000269\|PubMed:16724298,ECO:0000269\|PubMed:16823043,ECO:0000269\|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
P53582	262	310	301	301	Binding site	Note=Substrate;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|HAMAP-Rule:MF_03174,ECO:0000269\|PubMed:16724298,ECO:0000269\|PubMed:16823043,ECO:0000269\|PubMed:17114291;Dbxref=PMID:16724298,PMID:16823043,PMID:17114291
P53582	218	262	216	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	218	262	228	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	218	262	243	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	262	310	271	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	262	310	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	262	310	297	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	262	310	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	310	332	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	310	332	323	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H
P53582	310	332	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2B3H

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	METAP1	1.245174280985	0.0111397774890065

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
LUSC	METAP1	hsa-miR-143-3p	88	-0.339629990262902	0.00231353891581781

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUSC	METAP1	-0.135663252	0.001659752
TGCT	METAP1	-0.074623144	0.015921932
KIRP	METAP1	0.038692603	0.016306039

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with METAP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	METAP1	PFAS	0.816313037	1.54E-12
DLBC	Cell metabolism gene	METAP1	L2HGDH	0.821720396	8.23E-13
DLBC	Cell metabolism gene	METAP1	NUP54	0.870653559	8.95E-16
THYM	Cell metabolism gene	METAP1	NUP205	0.800785669	1.75E-28
THYM	Cell metabolism gene	METAP1	ENOPH1	0.801106047	1.60E-28
THYM	Cell metabolism gene	METAP1	POLR2B	0.80844974	2.12E-29
THYM	Cell metabolism gene	METAP1	NUP107	0.86604313	6.25E-38
THYM	CGC	METAP1	PWWP2A	0.80811595	2.33E-29
THYM	CGC	METAP1	RAD21	0.828370091	5.51E-32
THYM	CGC	METAP1	SUZ12	0.831030795	2.35E-32
THYM	CGC	METAP1	ABI1	0.875096709	1.24E-39
THYM	CGC	METAP1	TOP1	0.889305422	1.37E-42
THYM	Epifactor	METAP1	YY1	0.801280785	1.53E-28
THYM	Epifactor	METAP1	MASTL	0.802480492	1.11E-28
THYM	Epifactor	METAP1	RCOR1	0.827003644	8.49E-32
THYM	Epifactor	METAP1	SUZ12	0.831030795	2.35E-32
THYM	Epifactor	METAP1	PHF20L1	0.833492537	1.05E-32
THYM	Epifactor	METAP1	TAF4	0.8425155	4.94E-34
THYM	Epifactor	METAP1	ACTL6A	0.858217577	1.48E-36
THYM	IUPHAR	METAP1	SLC35A3	0.801739395	1.35E-28
THYM	IUPHAR	METAP1	MASTL	0.802480492	1.11E-28
THYM	IUPHAR	METAP1	OXSR1	0.808162854	2.30E-29
THYM	IUPHAR	METAP1	TOP1	0.889305422	1.37E-42
THYM	Kinase	METAP1	MASTL	0.802480492	1.11E-28
THYM	Kinase	METAP1	OXSR1	0.808162854	2.30E-29
THYM	Kinase	METAP1	PAN3	0.826674511	9.42E-32
THYM	TF	METAP1	YY1	0.801280785	1.53E-28
THYM	TF	METAP1	ZUFSP	0.802030395	1.25E-28
THYM	TF	METAP1	ELF1	0.813635424	4.83E-30
THYM	TF	METAP1	ZNF143	0.818443117	1.17E-30
THYM	TF	METAP1	ZNF207	0.843827518	3.11E-34
THYM	TF	METAP1	ZNF131	0.854117019	7.20E-36
THYM	TSG	METAP1	INTS6	0.812267192	7.17E-30
THYM	TSG	METAP1	SUZ12	0.831030795	2.35E-32
THYM	TSG	METAP1	LIN9	0.856386382	3.02E-36
THYM	TSG	METAP1	CCAR1	0.891835206	3.70E-43
UCS	Cell metabolism gene	METAP1	NUP205	0.800785669	1.75E-28
UCS	Cell metabolism gene	METAP1	ENOPH1	0.801106047	1.60E-28
UCS	Cell metabolism gene	METAP1	POLR2B	0.80844974	2.12E-29
UCS	Cell metabolism gene	METAP1	NUP107	0.86604313	6.25E-38
UCS	CGC	METAP1	PWWP2A	0.80811595	2.33E-29
UCS	CGC	METAP1	RAD21	0.828370091	5.51E-32
UCS	CGC	METAP1	SUZ12	0.831030795	2.35E-32
UCS	CGC	METAP1	ABI1	0.875096709	1.24E-39
UCS	CGC	METAP1	TOP1	0.889305422	1.37E-42
UCS	Epifactor	METAP1	YY1	0.801280785	1.53E-28
UCS	Epifactor	METAP1	MASTL	0.802480492	1.11E-28
UCS	Epifactor	METAP1	RCOR1	0.827003644	8.49E-32
UCS	Epifactor	METAP1	SUZ12	0.831030795	2.35E-32
UCS	Epifactor	METAP1	PHF20L1	0.833492537	1.05E-32
UCS	Epifactor	METAP1	TAF4	0.8425155	4.94E-34
UCS	Epifactor	METAP1	ACTL6A	0.858217577	1.48E-36
UCS	IUPHAR	METAP1	SLC35A3	0.801739395	1.35E-28
UCS	IUPHAR	METAP1	MASTL	0.802480492	1.11E-28
UCS	IUPHAR	METAP1	OXSR1	0.808162854	2.30E-29
UCS	IUPHAR	METAP1	TOP1	0.889305422	1.37E-42
UCS	Kinase	METAP1	MASTL	0.802480492	1.11E-28
UCS	Kinase	METAP1	OXSR1	0.808162854	2.30E-29
UCS	Kinase	METAP1	PAN3	0.826674511	9.42E-32
UCS	TF	METAP1	YY1	0.801280785	1.53E-28
UCS	TF	METAP1	ZUFSP	0.802030395	1.25E-28
UCS	TF	METAP1	ELF1	0.813635424	4.83E-30
UCS	TF	METAP1	ZNF143	0.818443117	1.17E-30
UCS	TF	METAP1	ZNF207	0.843827518	3.11E-34
UCS	TF	METAP1	ZNF131	0.854117019	7.20E-36
UCS	TSG	METAP1	INTS6	0.812267192	7.17E-30
UCS	TSG	METAP1	SUZ12	0.831030795	2.35E-32
UCS	TSG	METAP1	LIN9	0.856386382	3.02E-36
UCS	TSG	METAP1	CCAR1	0.891835206	3.70E-43

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	METAP1	GNAT1	-1.0348316939997	0.000149602949838969
THCA	METAP1	RAP1GDS1	-1.10586439664627	0.000331869180527397
BRCA	METAP1	CBWD1	1.03561500229833	0.000449442253060614
THCA	METAP1	CBWD1	-1.50317298135753	0.0006917829126832
LIHC	METAP1	GNAT1	1.01655826832652	0.000958264675071377
KIRP	METAP1	METAP2	1.2125553034505	0.00166679499670863
PRAD	METAP1	PDF	-1.83573074557218	0.00211503858224308
KIRP	METAP1	RAP1GDS1	1.5813279692516	0.00239070039242506
CHOL	METAP1	PDF	-2.35440894163977	0.00390625
COAD	METAP1	CBWD2	-2.30963913496783	0.00468936562538148
KIRC	METAP1	CBWD1	-1.07972278959177	0.00644033795389533
KIRC	METAP1	PDF	-2.08272493094078	0.00724874285490747
KIRP	METAP1	CBWD2	1.96991067828116	0.0093395933508873
LUAD	METAP1	CBWD2	-1.06262193861601	0.0129444588278098
PRAD	METAP1	CBWD2	1.16658303885594	0.0241985658238267
KIRC	METAP1	RPL35	-1.06475238059392	2.72286325678163e-08
BRCA	METAP1	PDF	-1.85666700432586	2.87720383141203e-13
LUSC	METAP1	PDF	-2.24754662802234	5.69044796414887e-09
LUAD	METAP1	PDF	-2.8456821603014	8.2686862267444e-10
KIRP	METAP1	RPL35	-1.52981101975496	9.0546440333128e-05
KIRP	METAP1	PDF	1.28164472282644	9.99853946268559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with METAP1

SMAD9, HECW2, GH2, CBWD1, LPPR2, CBWD2, EXOC3, RBM42, ZMAT2, HNRNPU, NAA40, NPPA, TRIM25, G3BP1, DCPS, ATG16L1, NR2C2, ZRANB1, MEOX2, GLRX3, NBR1, PLEKHG4, INCA1, SYTL4, ESR1, IMMP2L, KIF14, NUPR1, SMAD4, IBSP, RSL1D1, ITIH3, MRPS12, TCL1A, BTF3L4, CCL3L1, BTF3, TEX19,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
METAP1	chr4	99982441	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
METAP1	UCEC	chr4	99978957	99978957	A	G	Missense_Mutation	p.M329V	6
METAP1	LUAD	chr4	99982307	99982307	G	A	Missense_Mutation	p.G334R	6
METAP1	UCEC	chr4	99960603	99960603	G	A	Missense_Mutation	p.R140Q	4
METAP1	THYM	chr4	99978954	99978954	C	T	Missense_Mutation	p.P328S	3
METAP1	COAD	chr4	99969962	99969962	G	A	Missense_Mutation	p.R289Q	3
METAP1	ESCA	chr4	99960579	99960579	C	T	Missense_Mutation	p.S132L	3
METAP1	PAAD	chr4	99969935	99969935	C	T	Missense_Mutation	p.A280V	3
METAP1	PAAD	chr4	99982458	99982458	C	T	Missense_Mutation	p.S384F	3
METAP1	STAD	chr4	99960602	99960602	C	T	Nonsense_Mutation	p.R140*	2
METAP1	LUAD	chr4	99960598	99960598	G	A	Silent	p.G138G	2
METAP1	UCEC	chr4	99970013	99970013	T	C	Missense_Mutation	p.V306A	2
METAP1	LUAD	chr4	99962203	99962203	G	A	Missense_Mutation	p.E148K	2
METAP1	BLCA	chr4	99982412	99982412	G	C	Missense_Mutation	p.E369Q	2
METAP1	HNSC	chr4	99982433	99982433	G	C	Missense_Mutation	p.D376H	2
METAP1	BRCA	chr4	99966365	99966365	G	T	Missense_Mutation	p.D231Y	2
METAP1	LIHC	chr4	99955478	99955478	A	G	Silent		2
METAP1	UCEC	chr4	99916939	99916939	A	G	Missense_Mutation	p.D12G	2
METAP1	PAAD	chr4	99982458	99982458	C	T	Missense_Mutation		2
METAP1	UCEC	chr4	99962203	99962203	G	T	Nonsense_Mutation	p.E148*	2
METAP1	PAAD	chr4	99969935	99969935	C	T	Missense_Mutation		2
METAP1	UCEC	chr4	99962265	99962265	C	T	Silent	p.H168	2
METAP1	ESCA	chr4	99960579	99960579	C	T	Missense_Mutation		2
METAP1	STAD	chr4	99960602	99960602	C	T	Nonsense_Mutation	p.R140X	2
METAP1	UCEC	chr4	99966411	99966411	G	A	Missense_Mutation	p.R246Q	2
METAP1	STAD	chr4	99962266	99962266	G	A	Missense_Mutation	p.A169T	2
METAP1	UCEC	chr4	99969981	99969981	A	C	Silent	p.G295	2
METAP1	BLCA	chr4	99960563	99960563	C	G	Missense_Mutation		1
METAP1	SARC	chr4	99955406	99955406	G	T	Silent		1
METAP1	GBM	chr4	99960603	99960603	G	A	Missense_Mutation		1
METAP1	BLCA	chr4	99982412	99982412	G	C	Missense_Mutation		1
METAP1	SARC	chr4	99916908	99916908	G	T	Missense_Mutation		1
METAP1	STAD	chr4	99969899	99969899	G	A	Missense_Mutation	p.R268Q	1
METAP1	HNSC	chr4	99982433	99982433	G	C	Missense_Mutation		1
METAP1	BLCA	chr4	99960563	99960563	C	G	Missense_Mutation	p.Q127E	1
METAP1	SARC	chr4	99969975	99969975	G	T	Silent		1
METAP1	HNSC	chr4	99982424	99982424	C	A	Silent		1
METAP1	LUAD	chr4	99960603	99960603	G	C	Missense_Mutation	p.R140P	1
METAP1	SARC	chr4	99964539	99964539	G	T	Splice_Site		1
METAP1	LUSC	chr4	99982392	99982392	T	G	Missense_Mutation	p.L362R	1
METAP1	SARC	chr4	99955406	99955406	G	T	Silent	p.V64V	1
METAP1	KIRC	chr4	99955422	99955422	G	T	Nonsense_Mutation	p.E70X	1
METAP1	UCEC	chr4	99966380	99966380	T	-	Frame_Shift_Del	p.F236fs	1
METAP1	LUSC	chr4	99960601	99960601	G	A	Missense_Mutation	p.M139I	1
METAP1	CHOL	chr4	99916973	99916973	C	A	Silent	p.P23P	1
METAP1	SKCM	chr4	99969899	99969899	G	T	Missense_Mutation	p.R268L	1
METAP1	MESO	chr4	99955477	99955477	G	T	Missense_Mutation	p.R88I	1
METAP1	COAD	chr4	99964420	99964420	C	T	Silent	p.C179C	1
METAP1	SKCM	chr4	99969997	99969997	C	T	Missense_Mutation	p.H301Y	1
METAP1	LIHC	chr4	99960538	99960538	T	C	Silent		1
METAP1	SKCM	chr4	99962231	99962231	T	A	Missense_Mutation	p.I157N	1
METAP1	LIHC	chr4	99982389	99982389	T	C	Missense_Mutation		1
METAP1	SKCM	chr4	99966337	99966337	C	T	Silent	p.I221I	1
METAP1	LIHC	chr4	99966340	99966340	T	C	Silent		1
METAP1	LIHC	chr4	99960538	99960538	T	C	Silent	p.S118S	1
METAP1	ESCA	chr4	99982442	99982442	C	T	Missense_Mutation	p.R379W	1

Copy number variation (CNV) of METAP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across METAP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
94776	N/A	EC564045	DLGAP1	chr18	3591669	-	METAP1	chr4	99977855	-
53010	BRCA	TCGA-E2-A1IL-01A	METAP1	chr4	99917018	+	EIF4E	chr4	99823133	-
99140	STAD	TCGA-EQ-A4SO-01A	METAP1	chr4	99966461	+	IQGAP1	chr15	91030186	+
97630	N/A	BM149877	METAP1	chr4	99960616	+	NDUFA12	chr12	95367548	-
94776	N/A	AW352239	PERP	chr6	138412275	+	METAP1	chr4	99983570	-
94776	STAD	TCGA-BR-4292	PPP3CA	chr4	102267895	-	METAP1	chr4	99950017	+
94779	STAD	TCGA-BR-8678-01A	TSPAN5	chr4	99579297	-	METAP1	chr4	99950018	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	METAP1	0.00271553314816925	0.076
SARC	METAP1	0.00472706526477322	0.13
KIRP	METAP1	0.00753867458914122	0.2
TGCT	METAP1	0.0103177921580079	0.26
LUSC	METAP1	0.022572527290621	0.54

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	METAP1	0.0353192950860136	1
BRCA	METAP1	0.000610443685790466	0.02
ESCA	METAP1	0.000105342081678447	0.0035
BLCA	METAP1	0.0197360294170479	0.61

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P53582	DB04324	Ovalicin		Small molecule	Experimental
P53582	DB07901	5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE		Small molecule	Experimental
P53582	DB07902	TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE		Small molecule	Experimental
P53582	DB07903	3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE		Small molecule	Experimental
P53582	DB04324	Ovalicin
P53582	DB07901	5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE
P53582	DB07902	TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE
P53582	DB07903	3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source