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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PASK (NCBI Gene ID:23178)

Gene Summary

Gene Summary

Gene Information	Gene Name: PASK
	Gene ID: 23178
	Gene Symbol	PASK
	Gene ID	23178
	Gene Name	PAS domain containing serine/threonine kinase
	Synonyms	PASKIN\|STK37
	Cytomap	2q37.3
	Type of Gene	protein-coding
	Description	PAS domain-containing serine/threonine-protein kinaseper-arnt-sim (PAS) domain kinase
	Modification date	20200329
	UniProtAcc	Q96RG2

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PASK	GO:0006468	protein phosphorylation	16275910
Hgene	PASK	GO:0045719	negative regulation of glycogen biosynthetic process	16275910
Hgene	PASK	GO:0046777	protein autophosphorylation	20943661\|21418524

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'PASK[title] AND translation [title] AND human.'

Gene	Title	PMID
PASK	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000234040	242054457	242054592	In-frame
ENST00000405260	242054457	242054592	In-frame
ENST00000544142	242054457	242054592	In-frame
ENST00000234040	242054702	242054828	In-frame
ENST00000405260	242054702	242054828	In-frame
ENST00000544142	242054702	242054828	In-frame
ENST00000234040	242063363	242063548	Frame-shift
ENST00000405260	242063363	242063548	Frame-shift
ENST00000544142	242063363	242063548	Frame-shift
ENST00000234040	242079299	242079470	In-frame
ENST00000405260	242079299	242079470	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000544142	242054457	242054592	4017	2836	2970	1323	880	925
ENST00000234040	242054457	242054592	4589	3332	3466	1323	1066	1111
ENST00000405260	242054457	242054592	4959	3898	4032	1323	1066	1111
ENST00000544142	242054702	242054828	4017	2710	2835	1323	838	880
ENST00000234040	242054702	242054828	4589	3206	3331	1323	1024	1066
ENST00000405260	242054702	242054828	4959	3772	3897	1323	1024	1066
ENST00000234040	242079299	242079470	4589	563	733	1323	143	200
ENST00000405260	242079299	242079470	4959	1129	1299	1323	143	200

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q96RG2	143	200	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
Q96RG2	1066	1111	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
Q96RG2	1024	1066	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
Q96RG2	143	200	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
Q96RG2	1066	1111	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
Q96RG2	1024	1066	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
Q96RG2	880	925	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
Q96RG2	838	880	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
Q96RG2	143	200	119	190	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00140
Q96RG2	143	200	119	190	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00140
Q96RG2	1066	1111	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q96RG2	1024	1066	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q96RG2	1066	1111	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q96RG2	1024	1066	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q96RG2	1066	1111	1082	1089	Nucleotide binding	Note=ATP
Q96RG2	1066	1111	1082	1089	Nucleotide binding	Note=ATP
Q96RG2	1024	1066	1028	1028	Binding site	Note=ATP
Q96RG2	1024	1066	1028	1028	Binding site	Note=ATP
Q96RG2	1066	1111	1111	1111	Alternative sequence	ID=VSP_009302;Note=In isoform 2. Q->QVRAGQSR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8590280;Dbxref=PMID:8590280
Q96RG2	1066	1111	1111	1111	Alternative sequence	ID=VSP_009302;Note=In isoform 2. Q->QVRAGQSR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8590280;Dbxref=PMID:8590280
Q96RG2	838	880	844	844	Natural variant	ID=VAR_040991;Note=P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs36082918,PMID:17344846
Q96RG2	1024	1066	1028	1028	Mutagenesis	Note=Loss of autophosphorylating activity. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11459942,ECO:0000269\|PubMed:20943661;Dbxref=PMID:11459942,PMID:20943661
Q96RG2	1024	1066	1028	1028	Mutagenesis	Note=Loss of autophosphorylating activity. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11459942,ECO:0000269\|PubMed:20943661;Dbxref=PMID:11459942,PMID:20943661
Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Induces lower protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20943661;Dbxref=PMID:20943661
Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Induces lower protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20943661;Dbxref=PMID:20943661
Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Does not affect protein kinase activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20943661;Dbxref=PMID:20943661
Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Does not affect protein kinase activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:20943661;Dbxref=PMID:20943661
Q96RG2	838	880	850	850	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RG2	880	925	899	899	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RG2	1024	1066	1048	1048	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RG2	1024	1066	1048	1048	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RG2	1024	1066	1062	1062	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RG2	1024	1066	1062	1062	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96RG2	143	200	143	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	143	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	151	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	151	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	159	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	159	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	167	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	167	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	174	176	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	174	176	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	177	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	177	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	143	200	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1LL8
Q96RG2	1024	1066	1023	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1023	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1039	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1039	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1044	1046	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1044	1046	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1047	1050	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1047	1050	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1051	1056	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1024	1066	1051	1056	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1066	1111	1067	1072	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1066	1111	1067	1072	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1066	1111	1074	1082	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1066	1111	1074	1082	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1066	1111	1090	1095	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1066	1111	1090	1095	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1066	1111	1102	1121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS
Q96RG2	1066	1111	1102	1121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3DLS

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	PASK	1.23606928813559	0.0418110550539932
BRCA	PASK	-10.6518899739655	4.47072179592402e-17

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PCPG	PASK	0.067076191	0.019080732
LUSC	PASK	-0.064634762	0.048677268

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PASK (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	PASK	SIN3B	0.815927194	8.59E-12
CHOL	Cell metabolism gene	PASK	POLD1	0.829804562	1.85E-12
CHOL	CGC	PASK	MLLT6	0.817537976	7.24E-12
CHOL	CGC	PASK	POLD1	0.829804562	1.85E-12
CHOL	Epifactor	PASK	SIN3B	0.815927194	8.59E-12
CHOL	Epifactor	PASK	MLLT6	0.817537976	7.24E-12
TGCT	Cell metabolism gene	PASK	ELOVL6	0.832908919	2.06E-41
TGCT	Epifactor	PASK	TDRKH	0.826762903	2.59E-40
TGCT	Epifactor	PASK	GATAD2A	0.837360783	3.10E-42
TGCT	TF	PASK	ZNF610	0.822117002	1.64E-39
TGCT	TF	PASK	ZNF470	0.825781741	3.85E-40
TGCT	TF	PASK	GATAD2A	0.837360783	3.10E-42

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	PASK	UGP2	1.37057128313652	0.000135096452205652
LIHC	PASK	ELMOD1	1.03906770491282	0.0010070937054656
STAD	PASK	ELMOD1	1.33067116010125	0.00213704575063657
KICH	PASK	ELMOD1	-1.43246960890041	0.00250792503356934
THCA	PASK	PPP1R7	1.70362897941141	0.00276455766304897
CHOL	PASK	UGP2	-2.47087622660823	0.00390625
KICH	PASK	SIGLEC1	-1.32768790771951	0.00417518615722656
PRAD	PASK	SLC12A9	-1.27489934155832	0.00496210155254694
THCA	PASK	SIGLEC1	-1.10878027897022	0.00650758354344202
CHOL	PASK	GYS1	-1.30268708734842	0.0078125
PRAD	PASK	UGP2	1.94696236201846	1.70405367234428e-06
LUAD	PASK	UCK2	-2.27941246791722	1.8991612701991e-08
BRCA	PASK	PPP1R7	-1.48862908677711	1.96051131307798e-05
HNSC	PASK	UGP2	-4.96283153952528	1.97746885532979e-09
LUSC	PASK	HEG1	-2.11847918158545	2.04323490140462e-09
HNSC	PASK	UCK2	1.29024344780589	2.13636867556489e-05
COAD	PASK	ELMOD1	2.06434763353066	2.69412994384766e-05
LIHC	PASK	SLC12A9	-2.0460837651123	3.12340071872958e-06
LUSC	PASK	SIGLEC1	-2.38845427551476	3.23227619897643e-09
LUAD	PASK	HEG1	-2.50802185024224	4.92275588120863e-11
COAD	PASK	PTPRZ1	4.63021712532244	5.66244125366212e-07
KIRC	PASK	ELMOD1	-5.95667046797673	5.92159366245618e-10
KIRP	PASK	SIGLEC1	-4.97244665008249	6.0301274061203e-05
LUAD	PASK	SIGLEC1	-1.23534684435729	6.67041166586055e-09
HNSC	PASK	SLC12A9	-2.24050809154968	6.75183794101032e-05
BRCA	PASK	UGP2	-2.44498470169402	8.73190688506881e-24
THCA	PASK	ELMOD1	1.25061161005695	9.84416697162782e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PASK

STK16, FBL, PSMB1, WDR5, HSP90AA1, NLK, AGO1, AGO2, AP1G1, PRR14L, FAM120A, HJURP, IQGAP3, MAP7, MKI67, NOL9, NOM1, PRKRIR, PRPF6, EMILIN3, ZBTB21, OBSL1, IKBKAP, ZNF628, ZNF574, RAD50, RECQL4, SENP5, TAF6L, GTF3C2, TRMT2A, ZBTB24, ZNF638, ZNF768, BAG6, CEP78, LAS1L, RFPL2, KLK5, SFRP4, DNASE2B, PARK2, DCLRE1C, WNT4, AURKA, PRG2, B9D2, CEP44, XPO1, TRIM41, KIAA1683, FRMD1, ZNF550, C7orf69, WNT7A, FAM19A3, RASL10B, DEF8, PRKAA1, PASK, EGLN3, PIK3R1, IRS1, TNS3, PLK1, ORF3b, SLX4IP, nsp9, nsp16, HSCB, RQCD1, TRIM66, NINL, DNAJB13, CCDC14, DCTN2, DHFRL1, GOLGA1, VASP, VCL, TIMP3, ZBBX, CCL26, IQCF2, ADAMTS13, C4orf26, MFAP5, IGSF5, C2CD4B, DNA2, LINC01588, GTF3C4, FGF11, FBXO10, CTAG1B, FAM110D, FAM120AOS, FOXD4L6, PIF1, WNT10A, UPP1, INHBE, GZMH, KLK15, FAM43A, ENDOV, DHRS2, CDK20, NOXO1, SF3B3, RPUSD3, NPAS1, MAP2K2, ALDH3B1, WNT2, PODN, TRMU, PTPN18, NDP, WDR90, CTSG, WISP3, KLHL14, FOXD4,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PASK	chr2	242045997	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242046026	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242047601	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242047703	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242051654	C	T	single_nucleotide_variant	Uncertain_significance	Chronic_kidney_disease\|not_specified	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
PASK	chr2	242051829	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242063458	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242065635	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242065754	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242065756	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242065781	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242065798	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242065963	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242065986	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242066165	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242066245	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242066245	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242066250	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242066276	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242066584	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242072389	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242072411	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242072438	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242076560	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242077440	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
PASK	chr2	242078094	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PASK	chr2	242079465	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242080062	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PASK	chr2	242080153	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PASK	PRAD	chr2	242080067	242080067	C	T	Missense_Mutation	p.E100K	8
PASK	BLCA	chr2	242066314	242066314	T	C	Silent		7
PASK	CESC	chr2	242062183	242062183	G	A	Silent	p.F1012F	5
PASK	UCEC	chr2	242065855	242065855	C	T	Silent	p.P825	4
PASK	STAD	chr2	242076594	242076594	C	T	Missense_Mutation	p.S321N	4
PASK	KIRP	chr2	242065794	242065794	G	A	Missense_Mutation	p.H846Y	4
PASK	UCEC	chr2	242076462	242076462	G	A	Missense_Mutation	p.A365V	3
PASK	LUAD	chr2	242066278	242066278	C	A	Silent	p.P684P	3
PASK	UCEC	chr2	242072410	242072410	C	T	Missense_Mutation	p.V448I	3
PASK	LGG	chr2	242065692	242065692	G	A	Missense_Mutation		3
PASK	PAAD	chr2	242066535	242066535	C	T	Missense_Mutation	p.G599S	3
PASK	READ	chr2	242054518	242054518	G	A	Silent	p.F1091F	3
PASK	PAAD	chr2	242062165	242062165	G	A	Silent	p.D1018D	3
PASK	SKCM	chr2	242054730	242054730	G	A	Silent	p.S1057S	3
PASK	SKCM	chr2	242082349	242082349	G	A	Silent	p.T33T	3
PASK	BLCA	chr2	242066101	242066101	G	C	Silent	p.L743L	3
PASK	THYM	chr2	242065646	242065646	G	T	Missense_Mutation		3
PASK	UCS	chr2	242066686	242066686	A	C	Missense_Mutation	p.D548E	3
PASK	PAAD	chr2	242079416	242079416	G	A	Silent	p.L162L	3
PASK	BRCA	chr2	242051776	242051776	C	T	Missense_Mutation	p.E1138K	3
PASK	UCS	chr2	242079418	242079418	T	C	Missense_Mutation	p.D161G	3
PASK	PAAD	chr2	242080137	242080137	T	C	Silent	p.S76S	3
PASK	BRCA	chr2	242066754	242066754	C	T	Missense_Mutation	p.G526R	3
PASK	UCS	chr2	242078093	242078093	C	T	Silent	p.S239S	3
PASK	PAAD	chr2	242065640	242065640	C	T	Missense_Mutation	p.S897N	3
PASK	COAD	chr2	242063382	242063382	G	A	Silent	p.T962T	3
PASK	UCS	chr2	242062240	242062240	G	A	Silent	p.G993G	3
PASK	PAAD	chr2	242051830	242051830	G	A	Missense_Mutation	p.R1120C	3
PASK	UCEC	chr2	242063393	242063393	C	T	Missense_Mutation	p.A959T	3
PASK	UCEC	chr2	242066758	242066758	G	C	Missense_Mutation	p.S524R	3
PASK	KIRP	chr2	242082279	242082279	G	T	Missense_Mutation	p.L57I	2
PASK	SARC	chr2	242047682	242047682	C	A	Silent		2
PASK	ACC	chr2	242066763	242066763	C	A	Nonsense_Mutation	p.E523X	2
PASK	CESC	chr2	242080125	242080125	C	T	Silent		2
PASK	UCEC	chr2	242062183	242062183	G	A	Silent	p.F1012	2
PASK	COAD	chr2	242066314	242066314	T	C	Silent	p.A672A	2
PASK	PAAD	chr2	242079416	242079416	G	A	Silent		2
PASK	SARC	chr2	242054559	242054559	G	A	Nonsense_Mutation	p.Q1078*	2
PASK	SKCM	chr2	242078169	242078169	G	A	Missense_Mutation	p.S214F	2
PASK	PRAD	chr2	242066448	242066448	G	A	Missense_Mutation	p.P628S	2
PASK	SKCM	chr2	242054387	242054387	G	A	Missense_Mutation	p.S1135L	2
PASK	STAD	chr2	242066792	242066792	G	A	Missense_Mutation	p.A513V	2
PASK	STAD	chr2	242066644	242066644	A	G	Silent	p.A562A	2
PASK	HNSC	chr2	242065973	242065973	T	C	Missense_Mutation	p.E786G	2
PASK	LIHC	chr2	242066022	242066022	G	A	Missense_Mutation		2
PASK	UCEC	chr2	242063386	242063386	A	G	Missense_Mutation	p.L961P	2
PASK	KIRP	chr2	242082279	242082279	G	T	Missense_Mutation		2
PASK	SARC	chr2	242078117	242078117	G	A	Silent		2
PASK	SKCM	chr2	242072304	242072304	G	A	Missense_Mutation	p.P483L	2
PASK	PAAD	chr2	242080137	242080137	T	C	Silent		2
PASK	SKCM	chr2	242082329	242082329	G	A	Missense_Mutation	p.S40L	2
PASK	STAD	chr2	242066347	242066347	C	T	Silent	p.L661L	2
PASK	GBM	chr2	242065780	242065780	C	T	Silent	p.T850T	2
PASK	STAD	chr2	242066674	242066674	T	C	Silent	p.P552P	2
PASK	HNSC	chr2	242054809	242054809	T	C	Missense_Mutation	p.K1031R	2
PASK	UCEC	chr2	242063486	242063486	G	A	Silent	p.L928	2
PASK	LUAD	chr2	242066563	242066563	C	A	Silent	p.G589G	2
PASK	SARC	chr2	242062301	242062301	C	T	Missense_Mutation		2
PASK	SKCM	chr2	242065992	242065992	C	T	Missense_Mutation	p.D780N	2
PASK	BLCA	chr2	242046915	242046915	C	G	Splice_Site		2
PASK	SKCM	chr2	242079977	242079977	G	A	Missense_Mutation	p.P130S	2
PASK	STAD	chr2	242066073	242066073	C	A	Missense_Mutation	p.D753Y	2
PASK	BLCA	chr2	242082263	242082263	G	A	Missense_Mutation	p.T62I	2
PASK	HNSC	chr2	242079332	242079332	C	T	Missense_Mutation	p.D190N	2
PASK	LIHC	chr2	242075390	242075390	T	C	Missense_Mutation	p.Q401R	2
PASK	UCEC	chr2	242065629	242065629	G	A	Nonsense_Mutation	p.R901*	2
PASK	SKCM	chr2	242065957	242065957	G	A	Silent	p.V791V	2
PASK	COAD	chr2	242076435	242076435	G	A	Missense_Mutation	p.T374M	2
PASK	LUAD	chr2	242063433	242063433	C	A	Silent	p.L945L	2
PASK	SKCM	chr2	242046056	242046056	C	T	Silent	p.G1299G	2
PASK	STAD	chr2	242065617	242065617	G	A	Missense_Mutation	p.R905W	2
PASK	BRCA	chr2	242063401	242063401	G	C	Missense_Mutation	p.S956C	2
PASK	UCEC	chr2	242047601	242047601	C	T	Silent	p.P1216	2
PASK	UCEC	chr2	242065780	242065780	C	T	Silent	p.T850	2
PASK	LUAD	chr2	242079351	242079351	G	T	Missense_Mutation	p.S183R	2
PASK	PAAD	chr2	242051830	242051830	G	A	Missense_Mutation	p.R1127C	2
PASK	SKCM	chr2	242046057	242046057	C	T	Missense_Mutation	p.G1299E	2
PASK	STAD	chr2	242065717	242065717	G	A	Silent	p.V871V	2
PASK	BRCA	chr2	242065791	242065791	C	G	Missense_Mutation	p.V847L	2
PASK	UCEC	chr2	242051742	242051742	G	A	Missense_Mutation	p.S1149L	2
PASK	UCEC	chr2	242065812	242065812	C	T	Missense_Mutation	p.D840N	2
PASK	CHOL	chr2	242051786	242051786	G	A	Silent		2
PASK	LUAD	chr2	242047654	242047654	C	G	Missense_Mutation	p.E1199Q	2
PASK	STAD	chr2	242065690	242065690	G	A	Silent	p.R880R	2
PASK	UCEC	chr2	242051780	242051780	G	A	Silent	p.I1136	2
PASK	SKCM	chr2	242063468	242063468	G	A	Missense_Mutation	p.H934Y	2
PASK	STAD	chr2	242066792	242066792	G	A	Missense_Mutation		2
PASK	BLCA	chr2	242066280	242066280	G	A	Missense_Mutation	p.P684S	2
PASK	LUAD	chr2	242066662	242066662	C	G	Missense_Mutation	p.E556D	2
PASK	STAD	chr2	242080060	242080060	C	T	Missense_Mutation	p.R102Q	2
PASK	STAD	chr2	242062279	242062279	G	-	Frame_Shift_Del	p.K981fs	2
PASK	UCEC	chr2	242051816	242051816	G	A	Silent	p.I1124	2
PASK	KICH	chr2	242076636	242076636	G	A	Missense_Mutation	p.T307I	2
PASK	LIHC	chr2	242066087	242066087	A	-	Frame_Shift_Del	p.F748fs	2
PASK	UCEC	chr2	242065921	242065921	G	T	Silent	p.T803	2
PASK	PAAD	chr2	242065640	242065640	C	T	Missense_Mutation		2
PASK	SARC	chr2	242062177	242062177	C	T	Nonsense_Mutation	p.W1014*	2
PASK	SKCM	chr2	242077394	242077394	G	A	Missense_Mutation	p.P284S	2
PASK	THYM	chr2	242065646	242065646	G	T	Missense_Mutation	p.S895Y	2
PASK	SARC	chr2	242046865	242046865	G	A	Silent		2
PASK	BRCA	chr2	242079007	242079007	A	G	Missense_Mutation	p.C2R	2
PASK	STAD	chr2	242066640	242066640	T	G	Missense_Mutation	p.M564L	2
PASK	UCEC	chr2	242054538	242054538	C	T	Missense_Mutation	p.G1085S	2
PASK	LIHC	chr2	242077445	242077445	C	-	Frame_Shift_Del	p.E267fs	2
PASK	UCEC	chr2	242066117	242066117	G	A	Missense_Mutation	p.S738L	2
PASK	SARC	chr2	242062301	242062301	C	T	Missense_Mutation	p.R973K	2
PASK	SKCM	chr2	242054769	242054769	G	A	Silent	p.P1044P	2
PASK	SKCM	chr2	242077391	242077391	G	A	Missense_Mutation	p.P285S	2
PASK	SARC	chr2	242080155	242080155	G	T	Missense_Mutation		2
PASK	STAD	chr2	242077410	242077410	G	A	Silent	p.I278I	2
PASK	CESC	chr2	242047684	242047684	G	A	Silent		2
PASK	UCEC	chr2	242054745	242054745	C	A	Missense_Mutation	p.E1052D	2
PASK	UCEC	chr2	242076557	242076557	G	A	Silent	p.A148V	2
PASK	LGG	chr2	242065692	242065692	G	A	Missense_Mutation	p.R880C	2
PASK	PAAD	chr2	242051830	242051830	G	A	Missense_Mutation		2
PASK	SKCM	chr2	242051780	242051780	G	A	Silent	p.I1136I	2
PASK	STAD	chr2	242066073	242066073	C	A	Missense_Mutation		2
PASK	BLCA	chr2	242065894	242065894	C	T	Silent	p.R812R	2
PASK	LIHC	chr2	242075390	242075390	T	C	Missense_Mutation		2
PASK	PRAD	chr2	242079323	242079323	C	G	Missense_Mutation	p.A193P	2
PASK	LIHC	chr2	242066669	242066669	G	-	Frame_Shift_Del	p.P554fs	2
PASK	STAD	chr2	242080005	242080005	T	C	Silent	p.S120S	2
PASK	CESC	chr2	242062183	242062183	G	A	Silent		2
PASK	UCEC	chr2	242054766	242054766	T	G	Missense_Mutation	p.K1045N	2
PASK	BLCA	chr2	242046785	242046785	A	C	Missense_Mutation		2
PASK	UCEC	chr2	242078136	242078136	C	T	Missense_Mutation	p.R225H	2
PASK	LUAD	chr2	242078153	242078153	C	A	Missense_Mutation	p.R219S	2
PASK	UCS	chr2	242079939	242079939	T	G	Silent	p.T142T	2
PASK	SKCM	chr2	242075323	242075323	G	A	Silent	p.D423D	2
PASK	SKCM	chr2	242051690	242051690	G	A	Silent	p.I1166I	2
PASK	BLCA	chr2	242046892	242046892	C	T	Silent	p.G1230G	2
PASK	HNSC	chr2	242078139	242078139	C	T	Missense_Mutation	p.R224H	2
PASK	LIHC	chr2	242066156	242066156	C	-	Frame_Shift_Del	p.G725fs	1
PASK	MESO	chr2	242063376	242063376	G	C	Silent		1
PASK	SKCM	chr2	242065899	242065899	G	A	Nonsense_Mutation	p.R811*	1
PASK	STAD	chr2	242078072	242078072	G	A	Silent	p.S246S	1
PASK	SKCM	chr2	242075322	242075322	G	A	Missense_Mutation	p.P424S	1
PASK	BLCA	chr2	242046892	242046892	C	T	Silent		1
PASK	STAD	chr2	242082442	242082442	C	T	Silent		1
PASK	UCS	chr2	242062240	242062240	G	A	Silent		1
PASK	LGG	chr2	242046007	242046007	C	T	Missense_Mutation		1
PASK	LUAD	chr2	242054508	242054508	C	A	Missense_Mutation	p.D1095Y	1
PASK	BLCA	chr2	242076584	242076584	C	A	Silent	p.A324A	1
PASK	GBM	chr2	242054741	242054741	C	T	Missense_Mutation	p.A1054T	1
PASK	LUAD	chr2	242066565	242066565	C	A	Missense_Mutation	p.G589W	1
PASK	STAD	chr2	242051680	242051680	C	T	Missense_Mutation	p.A1170T	1
PASK	LIHC	chr2	242046889	242046889	C	A	Silent		1
PASK	MESO	chr2	242063376	242063376	G	C	Silent	p.P964P	1
PASK	SKCM	chr2	242080011	242080011	C	T	Nonsense_Mutation	p.W118*	1
PASK	ACC	chr2	242077469	242077469	G	T	Missense_Mutation	p.H259N	1
PASK	CESC	chr2	242054718	242054718	G	A	Silent		1
PASK	SKCM	chr2	242075321	242075321	G	A	Missense_Mutation	p.P424L	1
PASK	BLCA	chr2	242076584	242076584	C	A	Silent		1
PASK	COAD	chr2	242075408	242075408	G	A	Missense_Mutation	p.A395V	1
PASK	TGCT	chr2	242063441	242063441	T	G	Missense_Mutation	p.T943P	1
PASK	UCS	chr2	242078093	242078093	C	T	Silent		1
PASK	LGG	chr2	242062244	242062244	T	G	Missense_Mutation		1
PASK	LUAD	chr2	242066664	242066664	C	A	Nonsense_Mutation	p.E556*	1
PASK	PRAD	chr2	242066484	242066484	C	A	Nonsense_Mutation	p.E616*	1
PASK	BLCA	chr2	242072348	242072348	C	G	Missense_Mutation	p.Q468H	1
PASK	LIHC	chr2	242054738	242054738	T	C	Missense_Mutation	p.I1055V	1
PASK	STAD	chr2	242066171	242066171	G	A	Missense_Mutation	p.T720M	1
PASK	KIRP	chr2	242065794	242065794	G	A	Missense_Mutation		1
PASK	OV	chr2	241695558	241695558	G	A	Nonsense_Mutation		1
PASK	SARC	chr2	242062177	242062177	C	T	Nonsense_Mutation		1
PASK	SKCM	chr2	242062232	242062232	G	A	Missense_Mutation	p.S996F	1
PASK	ACC	chr2	242066763	242066763	C	A	Nonsense_Mutation	p.E523*	1
PASK	SKCM	chr2	242063523	242063523	C	A	Silent	p.V915V	1
PASK	COAD	chr2	242075415	242075415	C	T	Missense_Mutation	p.D393N	1
PASK	THCA	chr2	242066830	242066830	G	A	Silent		1
PASK	UCS	chr2	242066686	242066686	A	C	Missense_Mutation		1
PASK	LUAD	chr2	242076568	242076568	C	T	Missense_Mutation	p.A330T	1
PASK	LUSC	chr2	242078087	242078087	C	A	Missense_Mutation	p.W241C	1
PASK	GBM	chr2	242065780	242065780	C	T	Silent		1
PASK	STAD	chr2	242065963	242065963	C	T	Silent	p.S789S	1
PASK	UCEC	chr2	242076557	242076557	G	A	Silent	p.S333S	1
PASK	STAD	chr2	242066359	242066359	C	T	Silent	p.L657L	1
PASK	KIRP	chr2	242079975	242079975	A	T	Silent		1
PASK	LUAD	chr2	242046118	242046118	C	G	Missense_Mutation	p.A1279P	1
PASK	OV	chr2	242078140	242078140	G	A	Missense_Mutation	p.R224C	1
PASK	SARC	chr2	242045992	242045992	G	T	Missense_Mutation		1
PASK	SARC	chr2	242076620	242076620	G	T	Missense_Mutation		1
PASK	SKCM	chr2	242046123	242046123	G	A	Missense_Mutation	p.S1277F	1
PASK	BLCA	chr2	242063472	242063472	G	A	Silent		1
PASK	CESC	chr2	242080125	242080125	C	T	Silent	p.Q80Q	1
PASK	SKCM	chr2	242065912	242065912	G	A	Silent	p.D806D	1
PASK	BLCA	chr2	242072348	242072348	C	G	Missense_Mutation		1
PASK	THCA	chr2	242065688	242065688	C	T	Missense_Mutation	p.G881E	1
PASK	UCS	chr2	242079418	242079418	T	C	Missense_Mutation		1
PASK	LGG	chr2	242066235	242066235	G	A	Silent		1
PASK	LUAD	chr2	242075382	242075382	C	A	Missense_Mutation	p.D404Y	1
PASK	LUSC	chr2	242066238	242066238	C	G	Missense_Mutation	p.D698H	1
PASK	READ	chr2	242066756	242066756	G	T	Missense_Mutation	p.P525H	1
PASK	HNSC	chr2	242072400	242072400	C	A	Missense_Mutation		1
PASK	STAD	chr2	242047655	242047655	A	G	Silent	p.F1205F	1
PASK	HNSC	chr2	242072400	242072400	C	A	Missense_Mutation	p.R451L	1
PASK	LIHC	chr2	242075394	242075394	A	G	Silent	p.L400L	1
PASK	STAD	chr2	242046073	242046073	C	T	Missense_Mutation	p.A1294T	1
PASK	LGG	chr2	242062244	242062244	T	G	Missense_Mutation	p.E992A	1
PASK	LUAD	chr2	242066327	242066327	T	A	Missense_Mutation	p.Q668L	1
PASK	OV	chr2	242051706	242051706	G	T	Missense_Mutation	p.T1161N	1
PASK	SARC	chr2	242051854	242051854	G	T	Missense_Mutation		1
PASK	SARC	chr2	242066388	242066388	G	T	Missense_Mutation		1
PASK	SKCM	chr2	242072401	242072401	G	A	Nonsense_Mutation	p.R451*	1
PASK	BLCA	chr2	242066101	242066101	G	C	Silent		1
PASK	CESC	chr2	242047684	242047684	G	A	Silent	p.L1196	1
PASK	SKCM	chr2	242051689	242051689	C	T	Missense_Mutation	p.E1167K	1
PASK	BLCA	chr2	242063472	242063472	G	A	Silent	p.L932L	1
PASK	COAD	chr2	242076585	242076585	G	A	Missense_Mutation	p.A324V	1
PASK	THCA	chr2	242063411	242063411	A	G	Missense_Mutation	p.S953P	1
PASK	UCS	chr2	242079939	242079939	T	G	Silent		1
PASK	LGG	chr2	242075446	242075446	A	C	Silent		1
PASK	LUAD	chr2	242065726	242065726	G	A	Silent	p.N868N	1
PASK	LUSC	chr2	242075391	242075391	G	T	Missense_Mutation	p.Q401K	1
PASK	READ	chr2	242082426	242082426	C	T	Missense_Mutation	p.A8T	1
PASK	HNSC	chr2	242054809	242054809	T	C	Missense_Mutation		1
PASK	STAD	chr2	242046073	242046073	C	T	Missense_Mutation	p.A1301T	1
PASK	HNSC	chr2	242054512	242054512	G	A	Silent	p.F1093F	1
PASK	LIHC	chr2	242063478	242063478	T	C	Silent	p.K930K	1
PASK	STAD	chr2	242079329	242079329	C	A	Missense_Mutation	p.G191C	1
PASK	LGG	chr2	242054372	242054372	C	T	Missense_Mutation	p.R1140Q	1
PASK	LUAD	chr2	242065750	242065750	T	C	Silent	p.P860P	1
PASK	OV	chr2	241725176	241725176	G	C	Silent	p.L351	1
PASK	SARC	chr2	242076460	242076460	G	T	Missense_Mutation		1
PASK	SARC	chr2	242046865	242046865	G	A	Silent	p.R1246	1
PASK	SKCM	chr2	242076539	242076539	G	A	Silent	p.V339V	1
PASK	BLCA	chr2	242066280	242066280	G	A	Missense_Mutation		1
PASK	SKCM	chr2	242066830	242066830	G	-	Frame_Shift_Del	p.H500fs	1
PASK	COAD	chr2	242077496	242077496	C	T	Missense_Mutation	p.V250I	1
PASK	LIHC	chr2	242065781	242065781	G	A	Missense_Mutation		1
PASK	LUAD	chr2	242077446	242077446	C	A	Silent	p.G266G	1
PASK	LUSC	chr2	242045998	242045998	G	A	Missense_Mutation	p.R1319C	1
PASK	READ	chr2	242054563	242054563	G	T	Missense_Mutation	p.F1041L	1
PASK	SKCM	chr2	242047622	242047622	G	C	Silent	p.T1209T	1
PASK	STAD	chr2	242046054	242046054	C	-	Frame_Shift_Del	p.G1307fs	1
PASK	HNSC	chr2	242078139	242078139	C	T	Missense_Mutation		1
PASK	KICH	chr2	242076636	242076636	G	A	Missense_Mutation		1
PASK	LIHC	chr2	242082337	242082337	G	-	Frame_Shift_Del	p.P37fs	1
PASK	STAD	chr2	242066771	242066771	A	G	Missense_Mutation	p.V520A	1
PASK	LGG	chr2	242075446	242075446	A	C	Silent	p.T382T	1
PASK	LUAD	chr2	242076536	242076536	C	A	Missense_Mutation	p.W340C	1
PASK	OV	chr2	242076663	242076663	C	T	Missense_Mutation	p.R298K	1
PASK	SARC	chr2	242047682	242047682	C	A	Silent	p.L1189L	1
PASK	SARC	chr2	242047682	242047682	C	A	Silent	p.L1196	1
PASK	SKCM	chr2	242082323	242082323	G	A	Missense_Mutation	p.S42F	1
PASK	BLCA	chr2	242046067	242046067	C	T	Missense_Mutation		1
PASK	CHOL	chr2	242051786	242051786	G	A	Silent	p.I1141I	1
PASK	COAD	chr2	242079986	242079986	C	T	Missense_Mutation	p.V127M	1
PASK	THYM	chr2	242046027	242046027	C	T	Missense_Mutation	p.G1316D	1
PASK	LIHC	chr2	242065850	242065850	T	C	Missense_Mutation		1
PASK	LUAD	chr2	242075338	242075338	C	A	Silent	p.G418G	1
PASK	LUSC	chr2	242054777	242054777	C	A	Nonsense_Mutation	p.E1042*	1
PASK	SARC	chr2	242077482	242077482	G	T	Missense_Mutation		1
PASK	SKCM	chr2	242066618	242066618	G	A	Missense_Mutation	p.A571V	1
PASK	HNSC	chr2	242065973	242065973	T	C	Missense_Mutation		1
PASK	STAD	chr2	242047655	242047655	A	G	Silent	p.F1198F	1
PASK	LGG	chr2	242066235	242066235	G	A	Silent	p.L699L	1
PASK	LUAD	chr2	242054438	242054438	C	A	Missense_Mutation	p.R1118L	1
PASK	SKCM	chr2	242066000	242066000	G	A	Missense_Mutation	p.S777F	1
PASK	BLCA	chr2	242072387	242072387	C	G	Silent		1
PASK	CHOL	chr2	242051786	242051786	G	A	Silent	p.I1134I	1
PASK	SKCM	chr2	242062230	242062230	G	A	Nonsense_Mutation	p.Q997X	1
PASK	STAD	chr2	242065617	242065617	G	A	Missense_Mutation		1
PASK	BLCA	chr2	242072387	242072387	C	G	Silent	p.R455R	1
PASK	COAD	chr2	242082262	242082262	T	C	Silent	p.T62T	1
PASK	LIHC	chr2	242066241	242066241	A	G	Missense_Mutation		1
PASK	LUAD	chr2	242066203	242066203	C	A	Silent	p.T709T	1
PASK	LUSC	chr2	242066525	242066525	G	A	Missense_Mutation	p.A602V	1
PASK	SKCM	chr2	242065645	242065645	G	A	Silent	p.S895S	1
PASK	HNSC	chr2	242046021	242046021	C	T	Missense_Mutation		1
PASK	KIRC	chr2	242079401	242079401	G	-	Frame_Shift_Del	p.L167fs	1
PASK	STAD	chr2	242076420	242076420	T	G	Missense_Mutation	p.K379T	1
PASK	LGG	chr2	242046007	242046007	C	T	Missense_Mutation	p.G1316R	1
PASK	LUAD	chr2	242080011	242080011	C	A	Missense_Mutation	p.W118C	1
PASK	PAAD	chr2	242066535	242066535	C	T	Missense_Mutation		1
PASK	SKCM	chr2	242080004	242080004	G	A	Missense_Mutation	p.P121S	1
PASK	STAD	chr2	242046054	242046054	C	-	Frame_Shift_Del		1
PASK	BLCA	chr2	242082263	242082263	G	A	Nonsense_Mutation	p.Q11*	1
PASK	COAD	chr2	242047665	242047665	G	A	Missense_Mutation	p.T1195M	1
PASK	THYM	chr2	242076461	242076461	C	T	Silent	p.A365A	1
PASK	LIHC	chr2	242076673	242076673	T	C	Missense_Mutation		1
PASK	LUAD	chr2	242063447	242063447	C	A	Missense_Mutation	p.A941S	1
PASK	KIRP	chr2	242077491	242077491	C	T	Silent	p.T251T	1
PASK	LIHC	chr2	242066636	242066636	C	-	Frame_Shift_Del	p.C565fs	1
PASK	MESO	chr2	242063442	242063442	C	A	Missense_Mutation		1
PASK	SKCM	chr2	242066588	242066588	G	A	Missense_Mutation	p.P581L	1
PASK	STAD	chr2	242082442	242082442	C	T	Silent	p.E2E	1
PASK	COAD	chr2	242066204	242066204	G	A	Missense_Mutation	p.T709M	1
PASK	STAD	chr2	242054701	242054701	A	G	Splice_Site	p.K1066_splice	1
PASK	LUAD	chr2	242054368	242054368	G	C	Missense_Mutation	p.F1141L	1
PASK	SARC	chr2	242078117	242078117	G	A	Silent	p.V231V	1
PASK	SKCM	chr2	242072321	242072321	G	A	Silent	p.L477L	1
PASK	BLCA	chr2	242065894	242065894	C	T	Silent		1
PASK	SKCM	chr2	242080011	242080011	C	T	Nonsense_Mutation	p.W118X	1
PASK	DLBC	chr2	242065635	242065635	A	G	Missense_Mutation	p.Y899H	1
PASK	HNSC	chr2	242054512	242054512	G	A	Silent		1
PASK	LUAD	chr2	242066605	242066605	C	A	Silent	p.R575R	1
PASK	MESO	chr2	242076549	242076549	C	A	Missense_Mutation		1
PASK	SARC	chr2	242082262	242082262	T	C	Missense_Mutation		1
PASK	SKCM	chr2	242062230	242062230	G	A	Nonsense_Mutation	p.Q997*	1
PASK	STAD	chr2	242075305	242075305	G	A	Silent	p.D429D	1
PASK	COAD	chr2	242066276	242066276	G	C	Missense_Mutation	p.T685R	1
PASK	STAD	chr2	242046054	242046054	C	-	Frame_Shift_Del	p.G1300fs	1
PASK	LGG	chr2	242076463	242076463	C	T	Missense_Mutation	p.A365T	1
PASK	PAAD	chr2	242062165	242062165	G	A	Silent		1
PASK	SARC	chr2	242046865	242046865	G	A	Silent	p.R1239R	1
PASK	SKCM	chr2	242054770	242054770	G	A	Missense_Mutation	p.P1044L	1
PASK	STAD	chr2	242066347	242066347	C	T	Silent		1
PASK	DLBC	chr2	242080119	242080119	A	C	Missense_Mutation	p.I82M	1
PASK	LIHC	chr2	242066415	242066415	C	A	Missense_Mutation		1
PASK	LUAD	chr2	242054766	242054766	T	C	Silent	p.K1045K	1

Copy number variation (CNV) of PASK
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PASK
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
88817	Non-Cancer	43N	AP1M2	chr19	10689567	-	PASK	chr2	242072445	-
90598	LUAD	TCGA-55-6985-01A	PASK	chr2	242079936	-	BOK	chr2	242509540	+
74638	STAD	TCGA-VQ-AA69	PASK	chr2	242046767	-	DYSF	chr2	71908130	+
87502	LUSC	TCGA-39-5022	PASK	chr2	242088828	-	STK25	chr2	242440211	-
88817	THYM	TCGA-XH-A853-01A	RAMP1	chr2	238786003	+	PASK	chr2	242077981	+
88823	STAD	TCGA-BR-A4QI-01A	TAF6L	chr11	62538962	+	PASK	chr2	242051854	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	PASK	0.000195156169239497	0.0053
HNSC	PASK	0.00518948194061453	0.13
KIRC	PASK	0.0424839419496714	1
SARC	PASK	6.91014412883893e-06	0.00019

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	PASK	0.00648015379098751	0.19
LIHC	PASK	0.000704925428959207	0.023
KIRC	PASK	0.00153181228035902	0.047
LGG	PASK	7.93889262715385e-05	0.0026
BRCA	PASK	0.00489166718408791	0.15
HNSC	PASK	0.0350471006302567	0.98

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0004352	Autistic Disorder	1	CTD_human
C2931817	Chromosome 2q37 deletion syndrome	1	CTD_human