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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PLXNB2 (NCBI Gene ID:23654)

Gene Summary

Gene Summary

Gene Information	Gene Name: PLXNB2
	Gene ID: 23654
	Gene Symbol	PLXNB2
	Gene ID	23654
	Gene Name	plexin B2
	Synonyms	MM1\|Nbla00445\|PLEXB2\|dJ402G11.3
	Cytomap	22q13.33
	Type of Gene	protein-coding
	Description	plexin-B2
	Modification date	20200313
	UniProtAcc	O15031

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PLXNB2	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	16122393
Hgene	PLXNB2	GO:0010976	positive regulation of neuron projection development	16122393

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'PLXNB2[title] AND translation [title] AND human.'

Gene	Title	PMID
PLXNB2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000449103	50715270	50715335	Frame-shift
ENST00000359337	50715270	50715335	Frame-shift
ENST00000359337	50718058	50718205	In-frame
ENST00000449103	50718058	50718205	In-frame
ENST00000449103	50718433	50718500	Frame-shift
ENST00000359337	50718433	50718500	Frame-shift
ENST00000359337	50720612	50720742	Frame-shift
ENST00000449103	50720612	50720742	Frame-shift
ENST00000359337	50721478	50721615	Frame-shift
ENST00000449103	50721478	50721615	Frame-shift
ENST00000359337	50722560	50722642	Frame-shift
ENST00000449103	50722560	50722642	Frame-shift
ENST00000449103	50723001	50723094	In-frame
ENST00000359337	50723001	50723094	In-frame
ENST00000449103	50724228	50724330	In-frame
ENST00000359337	50724228	50724330	In-frame
ENST00000359337	50725539	50725693	Frame-shift
ENST00000449103	50725539	50725693	Frame-shift
ENST00000359337	50726095	50726222	Frame-shift
ENST00000449103	50726095	50726222	Frame-shift
ENST00000449103	50727945	50729026	3UTR-3CDS
ENST00000359337	50727945	50729026	3UTR-3CDS
ENST00000359337	50733147	50733207	3UTR-3UTR
ENST00000449103	50733154	50733207	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000359337	50718058	50718205	6368	4352	4498	1838	1414	1463
ENST00000449103	50718058	50718205	6400	4384	4530	1838	1414	1463
ENST00000359337	50723001	50723094	6368	2198	2290	1838	696	727
ENST00000449103	50723001	50723094	6400	2230	2322	1838	696	727
ENST00000359337	50724228	50724330	6368	2096	2197	1838	662	696
ENST00000449103	50724228	50724330	6400	2128	2229	1838	662	696

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
O15031	696	727	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
O15031	1414	1463	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
O15031	662	696	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
O15031	696	727	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
O15031	1414	1463	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
O15031	662	696	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
O15031	696	727	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
O15031	662	696	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
O15031	696	727	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
O15031	662	696	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
O15031	1414	1463	1219	1838	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
O15031	1414	1463	1219	1838	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
O15031	1414	1463	1462	1469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4E71
O15031	1414	1463	1462	1469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4E71

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	PLXNB2	1.0704219528128	0.0093395933508873
THCA	PLXNB2	2.68605428505058	7.49003326178242e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
KIRC	PLXNB2	3	2	0.0134505554092175	0.649385731918239	0.572006688596491	-0.51675882088348	-0.643346824855674
LUAD	PLXNB2	3	2	0.0269100418647071	0.667451883425245	0.568503515625001	0.073177710748138	0.244407122512773

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
UCEC	PLXNB2	3	2	0.04505079509938	0.687464407612032	0.550965057471265	-0.560184839674956	-0.958049871109493

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PCPG	PLXNB2	-0.088996448	0.027117153

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PLXNB2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	PLXNB2	PISD	0.82810868	5.99E-32
THYM	Cell metabolism gene	PLXNB2	AGRN	0.842137408	5.63E-34
THYM	Cell metabolism gene	PLXNB2	FKBP9	0.812592861	6.53E-30
THYM	Cell metabolism gene	PLXNB2	UGGT2	0.824504098	1.85E-31
THYM	Cell metabolism gene	PLXNB2	SDC4	0.830988308	2.38E-32
THYM	CGC	PLXNB2	FKBP9	0.812592861	6.53E-30
THYM	CGC	PLXNB2	ZNRF3	0.827264967	7.82E-32
THYM	CGC	PLXNB2	SDC4	0.830988308	2.38E-32
THYM	IUPHAR	PLXNB2	LTBR	0.817966916	1.35E-30
THYM	IUPHAR	PLXNB2	PISD	0.82810868	5.99E-32
THYM	IUPHAR	PLXNB2	ITGA3	0.841919066	6.08E-34
THYM	IUPHAR	PLXNB2	MMP14	0.810347829	1.24E-29
THYM	IUPHAR	PLXNB2	CAPN2	0.805938339	4.28E-29
THYM	TF	PLXNB2	KLF11	0.823573975	2.47E-31
UCS	Cell metabolism gene	PLXNB2	AGRN	0.842137408	5.63E-34
UCS	Cell metabolism gene	PLXNB2	SDC4	0.830988308	2.38E-32
UCS	Cell metabolism gene	PLXNB2	PISD	0.82810868	5.99E-32
UCS	Cell metabolism gene	PLXNB2	UGGT2	0.824504098	1.85E-31
UCS	Cell metabolism gene	PLXNB2	FKBP9	0.812592861	6.53E-30
UCS	CGC	PLXNB2	ZNRF3	0.827264967	7.82E-32
UCS	CGC	PLXNB2	SDC4	0.830988308	2.38E-32
UCS	CGC	PLXNB2	FKBP9	0.812592861	6.53E-30
UCS	IUPHAR	PLXNB2	PISD	0.82810868	5.99E-32
UCS	IUPHAR	PLXNB2	LTBR	0.817966916	1.35E-30
UCS	IUPHAR	PLXNB2	ITGA3	0.841919066	6.08E-34
UCS	IUPHAR	PLXNB2	MMP14	0.810347829	1.24E-29
UCS	IUPHAR	PLXNB2	CAPN2	0.805938339	4.28E-29
UCS	TF	PLXNB2	KLF11	0.823573975	2.47E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	PLXNB2	RND3	1.04818253915572	0.000102202753672845
BLCA	PLXNB2	RND3	-1.46994698351353	0.000335693359375
KICH	PLXNB2	SEMA3E	1.26583935097358	0.00115483999252319
LUAD	PLXNB2	ARHGEF12	-1.29693734156383	0.00121089428940613
THCA	PLXNB2	SEMA3E	1.72226565186768	0.00146528750243568
COAD	PLXNB2	RRAS	-1.30958080984356	0.00160405039787293
STAD	PLXNB2	SEMA3E	-1.55829472292672	0.00275033386424184
COAD	PLXNB2	SEMA4F	-1.00124180744174	0.00322914123535157
KICH	PLXNB2	RND3	2.60438944099854	0.00378090143203735
COAD	PLXNB2	SEMA3F	-2.44917846077769	0.00390031933784485
CHOL	PLXNB2	SEMA4F	-4.45345226581299	0.00390625
CHOL	PLXNB2	RND3	-3.50360238513578	0.00390625
CHOL	PLXNB2	SEMA4D	-1.65355850561595	0.0078125
CHOL	PLXNB2	ARHGEF12	-3.54986118090384	0.0078125
BRCA	PLXNB2	SEMA4F	-1.2313924469295	0.00820001368943606
ESCA	PLXNB2	SEMA4F	-4.4630640107767	0.013671875
ESCA	PLXNB2	MET	1.7974042761042	0.0185546875
KIRP	PLXNB2	ARHGEF11	-2.93532839044973	0.0194480954669416
CHOL	PLXNB2	RND1	-1.12834179347783	0.01953125
COAD	PLXNB2	RND3	-1.03108570831106	0.0381683111190796
CHOL	PLXNB2	SEMA3F	-1.27913303181879	0.0390625
LIHC	PLXNB2	SEMA4F	-1.46434046993899	1.09871251804152e-08
KIRC	PLXNB2	SEMA4D	-1.33732417750527	1.29783194913552e-06
THCA	PLXNB2	RRAS	2.55390821223837	1.34811402718136e-08
KIRC	PLXNB2	SEMA3F	2.05843236258847	1.44148329893084e-11
THCA	PLXNB2	MET	2.09020268709397	1.50904867455457e-10
KIRC	PLXNB2	SEMA3E	2.08793305515575	1.55238188425888e-10
HNSC	PLXNB2	SEMA3E	4.22690714032052	1.99774895008887e-05
KICH	PLXNB2	SEMA3F	1.63660477609347	2.5629997253418e-06
LUSC	PLXNB2	SEMA3F	2.63153116267794	3.32807340670689e-07
LIHC	PLXNB2	SEMA3E	3.8823538866985	3.59406613648813e-06
LUAD	PLXNB2	RRAS	-4.22934415046406	3.59910232594763e-11
LUSC	PLXNB2	ARHGEF12	-4.31287793286558	3.85129646231505e-08
LIHC	PLXNB2	ARHGEF12	-1.41507255727965	4.08456474127691e-05
KIRP	PLXNB2	ARHGEF12	-1.02134884587413	4.20957803726197e-07
PRAD	PLXNB2	MET	1.64643528857984	4.53264387257039e-06
KIRP	PLXNB2	MET	1.52040209913428	4.6566128730774e-10
LIHC	PLXNB2	RND3	-4.68514746510352	4.91907449309094e-09
BRCA	PLXNB2	SEMA3F	1.85124094372612	5.1639316957333e-15
LIHC	PLXNB2	ARHGEF11	-3.84984442030122	5.1965939338348e-08
LUAD	PLXNB2	SEMA3E	-1.09827969005927	6.23590787285683e-08
LIHC	PLXNB2	SEMA3F	-1.80378385104422	7.79049220721842e-10
KICH	PLXNB2	MET	1.18206250071648	8.34465026855468e-07
PRAD	PLXNB2	RRAS	-2.03094624890416	8.40517570249428e-09
LUSC	PLXNB2	SEMA4F	2.02755015850579	9.88885026766033e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PLXNB2

ARHGEF11, RND1, PTN, ARHGEF12, PLCG1, HMOX2, CENPU, PFDN1, C12orf57, TACC1, NIF3L1, FBXO6, CCDC8, RHOD, PVRIG, HLA-E, LMAN2, BTNL8, PTCH1, PTPRK, SIAE, LYPD6, NTRK1, TMX1, DEFA1, DEFA5, ST8SIA4, IL17RC, TMED6, SCGB1D1, ADAM21, TLR1, IL27RA, MPPE1, TMPRSS3, TRIM25, PTPRO, RNF4, GRB2, KIAA1429, VDAC2, VDAC3, APEX1, LMBR1L, FAM105A, PLEKHA4, E, M, nsp4, nsp6, ORF7a, ORF7b, ORF8, ST7, RET, FKBP8, SEC61B, E5a, E5b, DNAJC1, DNAJC25, ARF6, ATP2A1, CYP2C9, DERL1, DHFRL1, ELOVL5, EMD, HSD17B11, HSD3B7, KRAS, LAMP2, LAMP3, KIAA1715, LRRC59, LYN, MARCKS, METTL7A, RAB2A, RAB35, RAB5C, RAB9A, RPN1, RPN2, SEC62, SSR1, SMAD4, EDDM3B, LGALS1, PATE1, LY86, RNF149, SLC22A3, FBXO2, ZDHHC12, SEMA4C, SCGB2A1, KLRC1, CDHR3, C2CD4B, CRYZL1, C7orf34, CLEC12B, BTNL3, C1orf54, RLN1, CYHR1, APOA2, CD160, SERGEF, DEFB135, SPCS1, PIGH, TRGV3, BRICD5, ASIC4, IGLL5, SDF2L1, CST11, CLEC2B, IL5RA, DNASE1L1, SLURP1, TMEM106A, CNTNAP3, GGH, HLA-G, TSHR, ECEL1, SFTPC, CBLN4, BTNL2, DPP4, TMPRSS11B, TMPRSS4, TMPRSS2, TMEM106B,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PLXNB2	chr22	50719833	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PLXNB2	chr22	50719860	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PLXNB2	chr22	50720295	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
PLXNB2	chr22	50721296	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PLXNB2	chr22	50722277	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PLXNB2	chr22	50725640	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PLXNB2	chr22	50727512	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PLXNB2	chr22	50728168	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene

Cancer type

Chromosome

Start

End

RefSeeq

MutSeq

Mutation type

AAchange

# samples

Copy number variation (CNV) of PLXNB2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PLXNB2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95424	ESCA	TCGA-IG-A97H	CPSF6	chr12	69656342	+	PLXNB2	chr22	50727571	-
95424	N/A	BF087400	KRT7	chr12	52638511	+	PLXNB2	chr22	50713901	-
98934	N/A	EC558010	PLXNB2	chr22	50734803	-	DARS	chr2	136664836	+
102928	READ	TCGA-F5-6814	PLXNB2	chr22	50733148	-	DENND6B	chr22	50757432	-
100995	BRCA	TCGA-AN-A0FV-01A	PLXNB2	chr22	50733148	-	DLG2	chr11	83691685	-
89789	KIRP	TCGA-P4-A5EB	PLXNB2	chr22	50722030	-	MAST4	chr5	66195778	+
89789	KIRP	TCGA-P4-A5EB-01A	PLXNB2	chr22	50722031	-	MAST4	chr5	66195779	+
92253	N/A	AA984189	PLXNB2	chr22	50723783	-	MERTK	chr2	112783070	-
81726	KIRC	TCGA-CZ-5460-01A	PLXNB2	chr22	50724229	-	NDUFA4L2	chr12	57631118	-
70674	N/A	AV688404	PLXNB2	chr22	50713413	-	NKAIN1	chr1	31685909	-
86557	PRAD	TCGA-J9-A52B-01A	PLXNB2	chr22	50713408	-	P4HTM	chr3	49038871	+
66578	N/A	AA532612	PLXNB2	chr22	50713408	-	PAK6	chr15	40536625	-
95424	N/A	BI033029	PLXNB2	chr22	50730363	+	PLXNB2	chr22	50730429	-
81444	STAD	TCGA-BR-7722-01A	PLXNB2	chr22	50724229	-	PRMT1	chr19	50191419	+
101174	N/A	BM979599	PLXNB2	chr22	50713472	+	RBM25	chr14	73586932	-
80746	STAD	TCGA-BR-A4PE-01A	PLXNB2	chr22	50745982	-	RPL23	chr17	37008985	-
66578	LGG	TCGA-TM-A84J	PLXNB2	chr22	50721479	-	SMPD4P1	chr22	20968022	-
66578	LGG	TCGA-TM-A84J-01A	PLXNB2	chr22	50721766	-	SMPD4P1	chr22	20968022	-
98981	CESC	TCGA-VS-A9V0-01A	PLXNB2	chr22	50718434	-	ST3GAL1	chr8	134511432	-
98320	LUAD	TCGA-55-7913-01B	PLXNB2	chr22	50713408	-	SUPT16H	chr14	21829491	-
66578	UCEC	TCGA-AJ-A3EM	PLXNB2	chr22	50733147	-	TMPRSS6	chr22	37499458	-
66578	UCEC	TCGA-AJ-A3EM-01A	PLXNB2	chr22	50733148	-	TMPRSS6	chr22	37499458	-
66578	UCEC	TCGA-AJ-A3EM-01A	PLXNB2	chr22	50745982	-	TMPRSS6	chr22	37499458	-
102670	N/A	AI492115	PLXNB2	chr22	50713479	+	TRIM25	chr17	54990919	+
99580	LUAD	TCGA-75-7031-01A	PLXNB2	chr22	50713408	-	UTRN	chr6	144665237	+
95424	STAD	TCGA-BR-A4PD-01A	RNF213	chr17	78354727	+	PLXNB2	chr22	50721195	-
95424	BRCA	TCGA-AR-A1AQ-01A	SBF1	chr22	50899952	-	PLXNB2	chr22	50723094	-
95424	BRCA	TCGA-E2-A1L7-01A	SHANK3	chr22	51160865	+	PLXNB2	chr22	50733207	-
95424	BRCA	TCGA-E2-A1L7-01A	SHANK3	chr22	51160865	-	PLXNB2	chr22	50729026	-
95424	N/A	AI964040	TACC1	chr8	38710310	-	PLXNB2	chr22	50728748	+
95424	HNSC	TCGA-BA-A4IF	TAF9	chr5	68665483	-	PLXNB2	chr22	50717440	-
95425	OV	TCGA-13-1403	TUBGCP6	chr22	50678632	-	PLXNB2	chr22	50723094	-
95425	OV	TCGA-13-1403-01A	TUBGCP6	chr22	50678633	-	PLXNB2	chr22	50723094	-
95425	UCEC	TCGA-EO-A22X-01A	TUBGCP6	chr22	50682148	-	PLXNB2	chr22	50723094	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	PLXNB2	0.00126095983361846	0.035
LUAD	PLXNB2	0.0137689697084492	0.37
BRCA	PLXNB2	0.0174544843332866	0.45

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	PLXNB2	0.0396898148940791	1
LUSC	PLXNB2	0.000635047486340152	0.021
GBM	PLXNB2	0.00791824248517245	0.23
LGG	PLXNB2	0.00233591044930948	0.072
LAML	PLXNB2	0.00836055687301263	0.23
ESCA	PLXNB2	0.023773401559122	0.64
THYM	PLXNB2	0.00155152420133988	0.05
SARC	PLXNB2	0.00341184287880242	0.1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source