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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: GSPT2 (NCBI Gene ID:23708)


Gene Summary

check button Gene Summary
Gene InformationGene Name: GSPT2
Gene ID: 23708
Gene Symbol

GSPT2

Gene ID

23708

Gene NameG1 to S phase transition 2
SynonymsERF3B|GST2
Cytomap

Xp11.22

Type of Geneprotein-coding
Descriptioneukaryotic peptide chain release factor GTP-binding subunit ERF3Beukaryotic peptide chain release factor subunit 3b
Modification date20200313
UniProtAcc

Q8IYD1


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0006415Translational termination
GO:0008135Translation factor activity, RNA binding
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
GSPT2>1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'GSPT2[title] AND translation [title] AND human.'
GeneTitlePMID
GSPT2Evolution of translation termination factor eRF3: is GSPT2 generated by retrotransposition of GSPT1's mRNA?16754297


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
LUADGSPT2-2.146260586018330.000586888531715471
HNSCGSPT21.059190719991910.00965754519575058
LUSCGSPT2-1.070221358465350.0407076861351475
KIRCGSPT2-2.006021311616544.95376546353503e-10
KIRPGSPT2-6.943600259872469.0546440333128e-05


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue
GBMGSPT2hsa-miR-144-3p93-10.0166666666666667


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
LUADGSPT2120.005797560874888450.1791046153846150.395787995212447-0.771096116930185-0.402230062517836
SKCMGSPT2120.03783507075559510.1469634146341460.35655908045977-0.06792031955720980.0782303729015822

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
CHOLGSPT20.0255990810.021115384
ESCAGSPT2-0.0237348350.035584755

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with GSPT2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
THYMEpifactorGSPT2TAF70.80247281.11E-28
THYMTFGSPT2ZNF2270.834669827.13E-33
UCSEpifactorGSPT2TAF70.80247281.11E-28
UCSTFGSPT2ZNF2270.834669827.13E-33


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
THCAGSPT2TRMT1121.993210142535890.000102991650070565
BRCAGSPT2UPF1-1.338990891513350.000117696606626909
BLCAGSPT2ETF1-5.52949288772530.000125885009765625
THCAGSPT2GSPT11.071871876100310.000163107625527599
LUSCGSPT2ETF1-1.149972310396750.000173983823784929
THCAGSPT2N6AMT1-1.169471192092610.000278681868396263
STADGSPT2EPRS-1.481715813246470.000789262883452143
PRADGSPT2EEF1G1.043017808977560.00116785923777763
CHOLGSPT2PABPC1-4.562725288153530.00390625
LIHCGSPT2UPF1-1.924913210825330.00427166918402987
KIRCGSPT2ETF1-2.846415421926030.00644033795389533
BLCAGSPT2PABPC11.314853027927460.0180816650390625
LUADGSPT2SMG1-1.401756586706250.0301695351050489
KIRPGSPT2EEF1G-2.054170742273680.0375871751457453
LUADGSPT2ETF1-2.016496498878372.27155024792558e-09
LIHCGSPT2EPRS-7.107310178115052.28054594243154e-08
BRCAGSPT2GSPT12.240142190815752.76767634190133e-17
LIHCGSPT2PABPC1-1.720769613621882.98009622125841e-06
PRADGSPT2UPF11.183121365151943.77428293642232e-05
KIRCGSPT2TRMT112-3.513113605293124.91010444643966e-09
PRADGSPT2PABPC1-2.102003183634768.55379952759014e-07
BRCAGSPT2TRMT112-1.602144418687549.36519472684852e-13
PRADGSPT2EPRS-1.763391274572659.52775218277559e-05


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with GSPT2
ETF1, PABPC1, UBR5, APP, CCT2, SMG1, UPF1, ATG7, ATP6V1C1, CTTN, GSPT1, IDE, NASP, RDX, SHMT1, SHMT2, SNX1, STAT1, SNX2, PAPSS2, SRSF12, C17orf85, PABPC4L, CLK3, LARP1B, CASC3, PABPC4, LARP1, PDE1C, IGF2BP3, MOV10, ELAVL2, ZC3H11A, PIP4K2C, CLK2, NCBP1, HNRNPC, FAM120A, ZCCHC3, YTHDC1, SRSF1, ZC3H18, PAIP1, RBBP6, IGF2BP1, DHX30, ADSS, AAR2, PIH1D1, ZDHHC18, ZDHHC23, nsp10, UFL1, DDRGK1, NUAK2, IGF2BP2, SRRM2, KIF1C, PUM2, PUM1, DHX36, APOBEC3B, IREB2, ATXN2, TRA2A, THRAP3, RBMS2, STAU2, RPL26L1, YBX1, BCLAF1, MKRN3, APOBEC3F, PABPC1L, PNN, RALY, ZNF326, TRA2B, ZFR, SUGP2, SRSF10, STAU1, YBX3, RNPS1, LARP4, RBM14-RBM4, MKRN1, MAGOH, U2SURP, Krr1,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo
GSPT2chrX51486790CTsingle_nucleotide_variantBenignnot_providedSO:0001583|missense_variantSO:0001583|missense_variant
GSPT2chrX51487038CCGDuplicationUncertain_significancenot_providedSO:0001589|frameshift_variantSO:0001589|frameshift_variant
GSPT2chrX51487145GAsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
GSPT2chrX51487743GAsingle_nucleotide_variantPathogenicAutistic_disorder|Delayed_speech_and_language_development|SeizuresSO:0001583|missense_variantSO:0001583|missense_variant
GSPT2chrX51487880CTsingle_nucleotide_variantUncertain_significancenot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
GSPT2BRCAchrX5148835351488353ACMissense_Mutationp.H544P4
GSPT2UCECchrX5148790451487904CTSilentp.T3944
GSPT2KIRPchrX5148695951486959GTSilentp.P79P4
GSPT2BRCAchrX5148851451488514AGMissense_Mutationp.K598E4
GSPT2KIRPchrX5148696051486960CTMissense_Mutationp.P80S4
GSPT2BLCAchrX5148844751488447CTSilentp.F575F4
GSPT2CESCchrX5148844851488448GAMissense_Mutation4
GSPT2UCECchrX5148753051487530GAMissense_Mutationp.E270K4
GSPT2UCECchrX5148828051488280CTMissense_Mutationp.R520C3
GSPT2LGGchrX5148825551488255TAMissense_Mutationp.D511E3
GSPT2ACCchrX5148704951487049TASilentp.P109P3
GSPT2LUADchrX5148735351487353CTMissense_Mutationp.H211Y3
GSPT2BRCAchrX5148849851488498CTSilentp.I5923
GSPT2CESCchrX5148844851488448GAMissense_Mutationp.V576M3
GSPT2COADchrX5148745351487453A-Frame_Shift_Delp.E244fs3
GSPT2UCECchrX5148829651488296ACMissense_Mutationp.Q525P3
GSPT2UCECchrX5148754351487543CTMissense_Mutationp.A274V2
GSPT2SKCMchrX5148823551488235CTMissense_Mutationp.P505S2
GSPT2CESCchrX5148734651487346CTSilent2
GSPT2UCSchrX5148706651487066AGMissense_Mutationp.E115G2
GSPT2STADchrX5148735451487354ACMissense_Mutationp.H211P2
GSPT2UCECchrX5148691151486911AGSilentp.V632
GSPT2UCECchrX5148768051487680GAMissense_Mutationp.E320K2
GSPT2HNSCchrX5148837651488376GTMissense_Mutationp.V552F2
GSPT2SKCMchrX5148678751486787CTMissense_Mutationp.S22F2
GSPT2CESCchrX5148694951486949CTMissense_Mutation2
GSPT2STADchrX5148709651487096ATMissense_Mutation2
GSPT2STADchrX5148786551487865A-Frame_Shift_Delp.P381fs2
GSPT2SKCMchrX5148693951486939CTSilentp.L73L2
GSPT2UCECchrX5148706751487067GTMissense_Mutationp.E115D2
GSPT2UCECchrX5148780351487803GAMissense_Mutationp.E361K2
GSPT2CESCchrX5148815451488154GAMissense_Mutation2
GSPT2STADchrX5148782051487820TCSilent2
GSPT2STADchrX5148771851487718TCSilentp.H332H2
GSPT2SKCMchrX5148711351487113GAMissense_Mutationp.E131K2
GSPT2UCECchrX5148712651487126CAMissense_Mutationp.P135H2
GSPT2UCECchrX5148783151487831TGMissense_Mutationp.L370R2
GSPT2HNSCchrX5148805251488052ACMissense_Mutationp.T444P2
GSPT2SKCMchrX5148795151487951GAMissense_Mutationp.G410E2
GSPT2UCECchrX5148723651487236CAMissense_Mutationp.P172T2
GSPT2UCECchrX5148785551487855GAMissense_Mutationp.G378D2
GSPT2KIRCchrX5148813851488138TASilentp.V472V2
GSPT2LGGchrX5148825551488255TAMissense_Mutation2
GSPT2STADchrX5148782051487820TCSilentp.C366C2
GSPT2SARCchrX5148690951486909GAMissense_Mutation2
GSPT2SKCMchrX5148832451488324CTSilentp.I534I2
GSPT2UCECchrX5148730251487302GAMissense_Mutationp.V194I2
GSPT2LUADchrX5148678351486783GTNonsense_Mutationp.E21*2
GSPT2STADchrX5148709651487096ATMissense_Mutationp.N125I2
GSPT2UCECchrX5148736651487366GAMissense_Mutationp.G215D2
GSPT2UCECchrX5148802551488025ACMissense_Mutationp.I435L2
GSPT2SARCchrX5148690951486909GAMissense_Mutationp.V63I2
GSPT2UCECchrX5148744151487441GTMissense_Mutationp.R240I2
GSPT2UCECchrX5148810551488105CTSilentp.L4612
GSPT2STADchrX5148726951487269AGMissense_Mutationp.K183E2
GSPT2SKCMchrX5148784451487844GASilentp.L374L2
GSPT2CESCchrX5148754551487545TCMissense_Mutation2
GSPT2UCECchrX5148745051487450ACMissense_Mutationp.K243T2
GSPT2UCECchrX5148849451488494CTMissense_Mutationp.T591I2
GSPT2STADchrX5148829451488294TCSilentp.V524V2
GSPT2HNSCchrX5148835451488354CAMissense_Mutationp.H544Q2
GSPT2SKCMchrX5148758751487587CTMissense_Mutationp.P289S2
GSPT2UCECchrX5148860351488603GASilentp.K6272
GSPT2LIHCchrX5148684951486849C-Frame_Shift_Delp.P43fs2
GSPT2STADchrX5148807851488078CTSilentp.S452S2
GSPT2HNSCchrX5148687051486870CTMissense_Mutationp.R50C2
GSPT2SKCMchrX5148847551488475CTMissense_Mutationp.R585C2
GSPT2CESCchrX5148820351488203GCMissense_Mutation2
GSPT2SKCMchrX5148706051487060CTMissense_Mutationp.S113F2
GSPT2GBMchrX5148738051487380GAMissense_Mutationp.G220R1
GSPT2LUSCchrX5148783251487832GTSilentp.L370L1
GSPT2STADchrX5148786451487865-AFrame_Shift_Insp.P381fs1
GSPT2BLCAchrX5148681051486810GTMissense_Mutationp.D30Y1
GSPT2HNSCchrX5148715851487158CGMissense_Mutationp.L146V1
GSPT2KIRPchrX5148795751487957CAMissense_Mutation1
GSPT2LIHCchrX5148690551486905T-Frame_Shift_Delp.P61fs1
GSPT2SKCMchrX5148807951488079GTMissense_Mutationp.G453W1
GSPT2GBMchrX5148788751487887CTMissense_Mutationp.P389S1
GSPT2LUSCchrX5148859151488591GASilentp.L623L1
GSPT2BLCAchrX5148859851488598GCMissense_Mutationp.E626Q1
GSPT2LUADchrX5148807051488070CGMissense_Mutationp.L450V1
GSPT2GBMchrX5148738051487380GAMissense_Mutation1
GSPT2LUSCchrX5148766351487663CAMissense_Mutationp.A314D1
GSPT2BLCAchrX5148686651486866CTSilentp.F48F1
GSPT2HNSCchrX5148755751487557GAMissense_Mutationp.E279K1
GSPT2LGGchrX5148843751488437GAMissense_Mutationp.R572Q1
GSPT2BLCAchrX5148848551488485CAMissense_Mutation1
GSPT2HNSCchrX5148835451488354CAMissense_Mutation1
GSPT2OVchrX5150519651505196ATMissense_Mutation1
GSPT2BLCAchrX5148690351486903CTMissense_Mutationp.P61S1
GSPT2CESCchrX5148800451488004GAMissense_Mutationp.D428N1
GSPT2LGGchrX5148683151486831GAMissense_Mutationp.A37T1
GSPT2LUADchrX5148847051488470TAMissense_Mutationp.I583N1
GSPT2STADchrX5148718551487185GTNonsense_Mutationp.E155X1
GSPT2BLCAchrX5148844751488447CTSilent1
GSPT2HNSCchrX5148805251488052ACMissense_Mutation1
GSPT2OVchrX5148677051486770CTSilentp.D16D1
GSPT2STADchrX5148718551487185GTNonsense_Mutationp.E155*1
GSPT2CESCchrX5148815451488154GAMissense_Mutationp.D478N1
GSPT2LUADchrX5148828351488283AGMissense_Mutationp.T521A1
GSPT2BLCAchrX5148828951488289GCMissense_Mutation1
GSPT2HNSCchrX5148837651488376GTMissense_Mutation1
GSPT2STADchrX5148760151487601TGMissense_Mutationp.S293R1
GSPT2KIRCchrX5148780251487802CTSilentp.I360I1
GSPT2CESCchrX5148820351488203GCMissense_Mutationp.R494T1
GSPT2LGGchrX5148843751488437GAMissense_Mutation1
GSPT2BLCAchrX5148681051486810GTMissense_Mutation1
GSPT2HNSCchrX5148687051486870CTMissense_Mutation1
GSPT2SARCchrX5148748551487485GTMissense_Mutation1
GSPT2STADchrX5148786551487866-AFrame_Shift_Insp.P381fs1
GSPT2SKCMchrX5148725451487254GAMissense_Mutationp.E178K1
GSPT2LIHCchrX5148734051487340AGSilent1
GSPT2LUADchrX5148679151486791GTSilentp.P23P1
GSPT2STADchrX5148789151487891GAMissense_Mutationp.C390Y1
GSPT2BLCAchrX5148859851488598GCMissense_Mutation1
GSPT2HNSCchrX5148755751487557GAMissense_Mutation1
GSPT2STADchrX5148718551487185GTNonsense_Mutation1
GSPT2CESCchrX5148800451488004GAMissense_Mutation1
GSPT2SKCMchrX5148852351488523CTMissense_Mutationp.P601S1
GSPT2CESCchrX5148754551487545TCMissense_Mutationp.Y275H1
GSPT2LIHCchrX5148839151488391TCSilent1
GSPT2LUADchrX5148792551487925GCMissense_Mutationp.Q401H1
GSPT2BLCAchrX5148848551488485CAMissense_Mutationp.T588K1
GSPT2HNSCchrX5148715851487158CGMissense_Mutation1
GSPT2THCAchrX5148752651487526ATSilentp.T268T1
GSPT2KIRPchrX5148695951486959GTSilent1
GSPT2SKCMchrX5148792751487927CTMissense_Mutationp.S402L1
GSPT2COADchrX5148727451487274GTMissense_Mutationp.E184D1
GSPT2LIHCchrX5148673751486737CTSilent1
GSPT2LUADchrX5148718351487183ACMissense_Mutationp.K154T1
GSPT2UCECchrX5148697451486974CTSilentp.A84A1
GSPT2KIRPchrX5148696051486960CTMissense_Mutation1
GSPT2SKCMchrX5148745251487452GAMissense_Mutationp.E244K1
GSPT2LUADchrX5148785451487854GCMissense_Mutationp.G378R1
GSPT2BLCAchrX5148828951488289GCMissense_Mutationp.D523H1
GSPT2KIRPchrX5148675851486758CASilent1
GSPT2UCSchrX5148706651487066AGMissense_Mutation1

check buttonCopy number variation (CNV) of GSPT2
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across GSPT2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
79377N/ABQ008176SBSNchr1936015640+GSPT2chrX51487604-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LUADGSPT20.00240815718338960.065
LIHCGSPT20.002408199110457150.065
BRCAGSPT20.02347506099486370.59
KIRPGSPT25.1350739011378e-050.0014

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
STADGSPT20.00362546015458150.12
LUADGSPT20.03305435626937160.96
KIRPGSPT20.007005323540186560.22
GBMGSPT20.01292118959919480.39
BRCAGSPT24.79045702893858e-050.0016

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source