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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CNOT10 (NCBI Gene ID:25904)

Gene Summary

Gene Summary

Gene Information	Gene Name: CNOT10
	Gene ID: 25904
	Gene Symbol	CNOT10
	Gene ID	25904
	Gene Name	CCR4-NOT transcription complex subunit 10
	Synonyms	-
	Cytomap	3p22.3
	Type of Gene	protein-coding
	Description	CCR4-NOT transcription complex subunit 10
	Modification date	20200313
	UniProtAcc	Q9H9A5

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CNOT10	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'CNOT10[title] AND translation [title] AND human.'

Gene	Title	PMID
CNOT10	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000328834	32746302	32746464	In-frame
ENST00000328834	32754718	32754861	Frame-shift
ENST00000328834	32757716	32757803	In-frame
ENST00000328834	32758645	32758729	In-frame
ENST00000328834	32761605	32761723	Frame-shift
ENST00000328834	32766941	32767091	In-frame
ENST00000328834	32769159	32769362	Frame-shift
ENST00000328834	32776291	32776468	In-frame
ENST00000328834	32778901	32778982	In-frame
ENST00000328834	32800949	32801063	In-frame
ENST00000328834	32804224	32804355	Frame-shift
ENST00000328834	32805946	32805982	In-frame
ENST00000328834	32811378	32811454	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000328834	32746302	32746464	2832	434	595	744	39	93
ENST00000328834	32757716	32757803	2832	890	976	744	191	220
ENST00000328834	32758645	32758729	2832	977	1060	744	220	248
ENST00000328834	32766941	32767091	2832	1179	1328	744	287	337
ENST00000328834	32776291	32776468	2832	1654	1830	744	446	504
ENST00000328834	32778901	32778982	2832	1831	1911	744	505	531
ENST00000328834	32800949	32801063	2832	1912	2025	744	532	569
ENST00000328834	32805946	32805982	2832	2157	2192	744	613	625

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	CNOT10	-2.1943232806481	0.000121572986245155
KIRC	CNOT10	1.29182504470331	2.23846498739956e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
MESO	CNOT10	hsa-miR-132-3p	92	0.319644595910419	0.00424328720006683

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CNOT10 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	CNOT10	MTMR14	0.800536043	1.87E-28
THYM	Cell metabolism gene	CNOT10	POLA2	0.803784422	7.75E-29
THYM	Cell metabolism gene	CNOT10	MED18	0.805227711	5.21E-29
THYM	Cell metabolism gene	CNOT10	NRF1	0.807873465	2.50E-29
THYM	CGC	CNOT10	CCND3	0.808908635	1.87E-29
THYM	Epifactor	CNOT10	MAZ	0.806183811	4.00E-29
THYM	Epifactor	CNOT10	H2AFX	0.809536004	1.56E-29
THYM	Epifactor	CNOT10	NASP	0.813655036	4.80E-30
THYM	Epifactor	CNOT10	TRIM28	0.827813758	6.57E-32
THYM	Epifactor	CNOT10	MAPKAPK3	0.839484867	1.41E-33
THYM	Epifactor	CNOT10	HMGN2	0.849785556	3.64E-35
THYM	IUPHAR	CNOT10	SLC25A38	0.80218059	1.20E-28
THYM	IUPHAR	CNOT10	TUBB	0.803686639	7.96E-29
THYM	IUPHAR	CNOT10	RGS10	0.818702124	1.09E-30
THYM	IUPHAR	CNOT10	TRIM28	0.827813758	6.57E-32
THYM	IUPHAR	CNOT10	MAPKAPK3	0.839484867	1.41E-33
THYM	Kinase	CNOT10	TRIM28	0.827813758	6.57E-32
THYM	Kinase	CNOT10	MAPKAPK3	0.839484867	1.41E-33
THYM	TF	CNOT10	MAZ	0.806183811	4.00E-29
THYM	TF	CNOT10	NRF1	0.807873465	2.50E-29
THYM	TF	CNOT10	THYN1	0.808019306	2.40E-29
THYM	TSG	CNOT10	NRF1	0.807873465	2.50E-29
THYM	TSG	CNOT10	H2AFX	0.809536004	1.56E-29
THYM	TSG	CNOT10	AIP	0.826467627	1.00E-31
UCS	Cell metabolism gene	CNOT10	MTMR14	0.800536043	1.87E-28
UCS	Cell metabolism gene	CNOT10	POLA2	0.803784422	7.75E-29
UCS	Cell metabolism gene	CNOT10	MED18	0.805227711	5.21E-29
UCS	Cell metabolism gene	CNOT10	NRF1	0.807873465	2.50E-29
UCS	CGC	CNOT10	CCND3	0.808908635	1.87E-29
UCS	Epifactor	CNOT10	MAZ	0.806183811	4.00E-29
UCS	Epifactor	CNOT10	H2AFX	0.809536004	1.56E-29
UCS	Epifactor	CNOT10	NASP	0.813655036	4.80E-30
UCS	Epifactor	CNOT10	TRIM28	0.827813758	6.57E-32
UCS	Epifactor	CNOT10	MAPKAPK3	0.839484867	1.41E-33
UCS	Epifactor	CNOT10	HMGN2	0.849785556	3.64E-35
UCS	IUPHAR	CNOT10	SLC25A38	0.80218059	1.20E-28
UCS	IUPHAR	CNOT10	TUBB	0.803686639	7.96E-29
UCS	IUPHAR	CNOT10	RGS10	0.818702124	1.09E-30
UCS	IUPHAR	CNOT10	TRIM28	0.827813758	6.57E-32
UCS	IUPHAR	CNOT10	MAPKAPK3	0.839484867	1.41E-33
UCS	Kinase	CNOT10	TRIM28	0.827813758	6.57E-32
UCS	Kinase	CNOT10	MAPKAPK3	0.839484867	1.41E-33
UCS	TF	CNOT10	MAZ	0.806183811	4.00E-29
UCS	TF	CNOT10	NRF1	0.807873465	2.50E-29
UCS	TF	CNOT10	THYN1	0.808019306	2.40E-29
UCS	TSG	CNOT10	NRF1	0.807873465	2.50E-29
UCS	TSG	CNOT10	H2AFX	0.809536004	1.56E-29
UCS	TSG	CNOT10	AIP	0.826467627	1.00E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	CNOT10	CNOT6L	-3.87663737407518	0.000364991836249828
LUAD	CNOT10	CNOT6L	-2.1633182779043	0.00060389239279426
KIRP	CNOT10	CNOT2	-1.10448855710506	0.00222697434946895
CHOL	CNOT10	CNOT6	-4.83321533739418	0.00390625
CHOL	CNOT10	CNOT8	-1.86479733449004	0.00390625
HNSC	CNOT10	RQCD1	1.97297540658491	0.00585215220849023
KICH	CNOT10	CNOT3	-1.1461250404339	0.00882232189178467
LUAD	CNOT10	TNKS1BP1	-1.41031433007162	0.0138138989413052
ESCA	CNOT10	TNKS1BP1	-2.3202441985139	0.0185546875
KICH	CNOT10	CNOT8	1.5062762229379	0.0255050659179687
THCA	CNOT10	CNOT7	-1.0100272557073	2.28966131184287e-07
LIHC	CNOT10	CNOT3	-1.23300348731276	3.17814170396599e-08
BRCA	CNOT10	CNOT3	-2.12666858749727	9.14937084127887e-14

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CNOT10

CNOT8, USP22, Cnot3, CHMP1B, EPAS1, VCP, CNOT6L, CNOT6, LYN, PPP6R1, HECW2, RNF219, TNRC6A, TNRC6C, KLHL20, CT55, MMP7, CAPZA2, CNOT7, BTRC, MED4, PCM1, CEP152, CNTROB, NINL, CENPJ, CNOT2, RPL10, NUP153, CNOT1, Cnot2, RC3H1, DUSP6, CNOT11, NANOS2, RIBC1, TOB1, TEX13A, GPBP1L1, GADD45B, HIF1AN, EGLN3, ESR2, RC3H2, ZC3H7A, TANK, DYRK1A, HTT, JPH2, nsp12, nsp2, nsp7, ESR1, AGO2, ANKRD17, CEP85, RQCD1, CPEB4, DDX3X, DDX6, EIF4ENIF1, FAM120C, FXR2, G3BP1, HELZ, KIAA0355, LSM14A, MEX3B, MKRN2, PATL1, PRRC2A, PUM1, RNF214, TNRC6B, UBAP2L, UNK, YTHDF1, YTHDF2, YTHDF3, ZFP36, FUBP3, SAMD4B, ZC3HAV1, CAPRIN1, PAIP1, PAIP2, LTB4R2, MKI67, Rnf183, ANAPC2, DCTN2, KRT18, KRT19, LCK, POLR2C, PXN, SEPT10, SQSTM1, STIL, SYNE3, PPP4R1L, TMEM131, NANOS1, FANCD2OS, FHL2, KRT38, MAGEA9, CDC16, TNKS1BP1, CNOT3, CAPZA1, BTG3, RIPK1, PABPN1L, RAVER1, CAPZB, SCGN, METTL21B, MINK1, TOP3B, CPEB1, BRD2,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CNOT10	KIRP	chr3	32766999	32766999	G	A	Missense_Mutation	p.S367N	4
CNOT10	ACC	chr3	32774948	32774948	A	-	Frame_Shift_Del	p.K418fs	3
CNOT10	BLCA	chr3	32814971	32814971	G	C	Missense_Mutation	p.Q701H	3
CNOT10	BLCA	chr3	32814971	32814971	G	C	Missense_Mutation		3
CNOT10	LIHC	chr3	32757737	32757737	A	G	Silent		3
CNOT10	ACC	chr3	32774948	32774948	A	-	Frame_Shift_Del	p.S476fs	2
CNOT10	BLCA	chr3	32811403	32811403	G	A	Missense_Mutation	p.E677K	2
CNOT10	LIHC	chr3	32801028	32801028	A	C	Missense_Mutation		2
CNOT10	UCEC	chr3	32750219	32750219	T	C	Missense_Mutation	p.Y113H	2
CNOT10	PAAD	chr3	32774973	32774973	T	C	Missense_Mutation		2
CNOT10	UCEC	chr3	32754825	32754825	T	G	Missense_Mutation	p.I179M	2
CNOT10	LIHC	chr3	32774933	32774933	A	G	Missense_Mutation		2
CNOT10	KIRP	chr3	32766999	32766999	G	A	Missense_Mutation	p.S307N	2
CNOT10	UCEC	chr3	32761719	32761719	A	C	Missense_Mutation	p.K286N	2
CNOT10	UCEC	chr3	32778971	32778971	A	C	Missense_Mutation	p.L528F	2
CNOT10	SARC	chr3	32805973	32805973	A	G	Missense_Mutation		2
CNOT10	PAAD	chr3	32774973	32774973	T	C	Missense_Mutation	p.V425A	2
CNOT10	THYM	chr3	32806258	32806258	G	A	Missense_Mutation		2
CNOT10	UCEC	chr3	32806208	32806208	C	T	Silent	p.S637	2
CNOT10	HNSC	chr3	32776347	32776347	C	A	Missense_Mutation	p.L465I	2
CNOT10	UCEC	chr3	32806251	32806251	G	A	Missense_Mutation	p.A652T	2
CNOT10	LIHC	chr3	32761627	32761627	A	-	Frame_Shift_Del	p.K256fs	2
CNOT10	HNSC	chr3	32750219	32750219	T	A	Missense_Mutation	p.Y113N	2
CNOT10	UCEC	chr3	32811380	32811380	C	T	Missense_Mutation	p.A669V	2
CNOT10	ESCA	chr3	32806207	32806207	C	A	Missense_Mutation	p.S697Y	2
CNOT10	LIHC	chr3	32757737	32757737	A	G	Silent	p.K198K	2
CNOT10	LUAD	chr3	32746360	32746360	G	A	Missense_Mutation	p.D59N	2
CNOT10	CESC	chr3	32776386	32776386	G	C	Missense_Mutation		2
CNOT10	STAD	chr3	32806268	32806268	C	T	Silent		2
CNOT10	CESC	chr3	32801030	32801030	T	G	Missense_Mutation		2
CNOT10	LGG	chr3	32754815	32754815	A	G	Missense_Mutation		2
CNOT10	ESCA	chr3	32737174	32737174	C	G	Silent	p.R19R	2
CNOT10	UCS	chr3	32778914	32778914	T	C	Silent	p.H509H	2
CNOT10	KIRC	chr3	32775009	32775009	C	G	Nonsense_Mutation	p.S437*	2
CNOT10	UCEC	chr3	32750180	32750180	G	T	Nonsense_Mutation	p.E100*	2
CNOT10	UVM	chr3	32769348	32769348	G	A	Missense_Mutation		1
CNOT10	GBM	chr3	32757745	32757745	C	A	Missense_Mutation		1
CNOT10	LIHC	chr3	32746405	32746405	A	-	Frame_Shift_Del	p.K74fs	1
CNOT10	SKCM	chr3	32769172	32769172	C	T	Missense_Mutation	p.S342L	1
CNOT10	KIRC	chr3	32750281	32750281	T	A	Silent	p.G133G	1
CNOT10	MESO	chr3	32754852	32754852	A	G	Silent	p.G188G	1
CNOT10	STAD	chr3	32769301	32769301	A	G	Missense_Mutation	p.Y445C	1
CNOT10	COAD	chr3	32746348	32746348	G	T	Missense_Mutation	p.D115Y	1
CNOT10	SARC	chr3	32769218	32769218	G	T	Missense_Mutation		1
CNOT10	THCA	chr3	32778913	32778913	A	G	Missense_Mutation		1
CNOT10	LIHC	chr3	32778959	32778959	A	-	Frame_Shift_Del	p.R524fs	1
CNOT10	SKCM	chr3	32745403	32745403	G	A	Silent	p.G22G	1
CNOT10	GBM	chr3	32769273	32769273	G	A	Missense_Mutation		1
CNOT10	BLCA	chr3	32758677	32758677	C	A	Missense_Mutation	p.S231Y	1
CNOT10	STAD	chr3	32769230	32769230	T	C	Silent	p.C421C	1
CNOT10	COAD	chr3	32746458	32746458	G	T	Missense_Mutation	p.K151N	1
CNOT10	SARC	chr3	32774937	32774937	G	T	Missense_Mutation		1
CNOT10	THCA	chr3	32778913	32778913	A	G	Missense_Mutation	p.H569R	1
CNOT10	LIHC	chr3	32804226	32804226	T	-	Splice_Site	p.F571_splice	1
CNOT10	SKCM	chr3	32745402	32745402	G	A	Missense_Mutation	p.G22E	1
CNOT10	BLCA	chr3	32761640	32761640	A	G	Missense_Mutation		1
CNOT10	HNSC	chr3	32750219	32750219	T	A	Missense_Mutation		1
CNOT10	PAAD	chr3	32757750	32757750	C	A	Missense_Mutation		1
CNOT10	STAD	chr3	32804301	32804301	C	G	Missense_Mutation	p.P656A	1
CNOT10	COAD	chr3	32774937	32774937	G	A	Missense_Mutation	p.G473D	1
CNOT10	LIHC	chr3	32757737	32757737	A	G	Silent	p.K258K	1
CNOT10	SARC	chr3	32737162	32737162	G	T	Missense_Mutation		1
CNOT10	LUAD	chr3	32761609	32761609	G	T	Missense_Mutation	p.A250S	1
CNOT10	SKCM	chr3	32800955	32800955	C	T	Missense_Mutation	p.S534F	1
CNOT10	BLCA	chr3	32769359	32769362	GGGG	-	Frame_Shift_Del		1
CNOT10	HNSC	chr3	32776347	32776347	C	A	Missense_Mutation		1
CNOT10	BLCA	chr3	32745388	32745388	A	G	Silent	p.T17T	1
CNOT10	LGG	chr3	32754815	32754815	A	G	Missense_Mutation	p.E236G	1
CNOT10	PAAD	chr3	32774973	32774973	T	C	Missense_Mutation	p.V485A	1
CNOT10	STAD	chr3	32754743	32754744	-	T	Frame_Shift_Ins	p.C212fs	1
CNOT10	THCA	chr3	32778913	32778913	A	G	Missense_Mutation	p.H509R	1
CNOT10	COAD	chr3	32806235	32806235	G	A	Silent	p.L706L	1
CNOT10	LIHC	chr3	32811404	32811404	A	G	Missense_Mutation	p.E737G	1
CNOT10	LUAD	chr3	32745455	32745455	G	T	Splice_Site		1
CNOT10	SKCM	chr3	32757801	32757801	C	T	Nonsense_Mutation	p.Q220*	1
CNOT10	BLCA	chr3	32811403	32811403	G	A	Missense_Mutation		1
CNOT10	HNSC	chr3	32758664	32758665	-	-	Frame_Shift_Ins		1
CNOT10	BLCA	chr3	32769359	32769362	GGGG	-	Splice_Site	p.KG404fs	1
CNOT10	LGG	chr3	32754815	32754815	A	G	Missense_Mutation	p.E176G	1
CNOT10	STAD	chr3	32806268	32806268	C	T	Silent	p.S657S	1
CNOT10	COAD	chr3	32811409	32811409	C	-	Frame_Shift_Del	p.V651fs	1
CNOT10	LIHC	chr3	32801028	32801028	A	C	Missense_Mutation	p.K618N	1
CNOT10	LIHC	chr3	32774933	32774933	A	G	Missense_Mutation	p.K412E	1
CNOT10	SARC	chr3	32805973	32805973	A	G	Missense_Mutation	p.M623V	1
CNOT10	LUAD	chr3	32805965	32805965	A	G	Missense_Mutation	p.N620S	1
CNOT10	SKCM	chr3	32811394	32811394	C	T	Missense_Mutation	p.H674Y	1
CNOT10	BLCA	chr3	32758677	32758677	C	A	Missense_Mutation		1
CNOT10	BLCA	chr3	32806176	32806183	GGTAAGCG	-	Frame_Shift_Del	p.GKR627fs	1
CNOT10	LGG	chr3	32805970	32805970	G	A	Missense_Mutation	p.A622T	1
CNOT10	PRAD	chr3	32811431	32811431	C	T	Missense_Mutation	p.A686V	1
CNOT10	STAD	chr3	32769301	32769301	A	G	Missense_Mutation	p.Y385C	1
CNOT10	UCEC	chr3	32745374	32745374	A	G	Missense_Mutation	p.K73E	1
CNOT10	ESCA	chr3	32737174	32737174	C	G	Silent	p.R19	1
CNOT10	LIHC	chr3	32774933	32774933	A	G	Missense_Mutation	p.K472E	1
CNOT10	SARC	chr3	32750305	32750305	G	T	Missense_Mutation	p.E141D	1
CNOT10	LUAD	chr3	32766952	32766952	G	C	Missense_Mutation	p.L291F	1
CNOT10	SKCM	chr3	32754731	32754731	C	T	Missense_Mutation	p.A148V	1
CNOT10	BRCA	chr3	32806282	32806282	C	G	Missense_Mutation	p.A662G	1
CNOT10	LGG	chr3	32778978	32778978	T	G	Missense_Mutation	p.L531V	1
CNOT10	PRAD	chr3	32800949	32800949	G	C	Splice_Site		1
CNOT10	STAD	chr3	32800967	32800967	G	A	Missense_Mutation	p.C538Y	1
CNOT10	UCEC	chr3	32750219	32750219	T	C	Missense_Mutation	p.Y173H	1
CNOT10	LIHC	chr3	32746399	32746399	T	-	Frame_Shift_Del	p.F73fs	1
CNOT10	SARC	chr3	32805973	32805973	A	G	Missense_Mutation	p.M683V	1
CNOT10	SKCM	chr3	32776307	32776307	G	A	Silent	p.S451S	1
CNOT10	BLCA	chr3	32769246	32769246	C	T	Missense_Mutation		1
CNOT10	HNSC	chr3	32758664	32758665	-	T	Frame_Shift_Ins	p.P227fs	1
CNOT10	LGG	chr3	32754743	32754744	-	T	Frame_Shift_Ins	p.F152fs	1
CNOT10	READ	chr3	32758656	32758656	G	A	Missense_Mutation	p.R284Q	1
CNOT10	STAD	chr3	32769230	32769230	T	C	Silent	p.C361C	1
CNOT10	UCEC	chr3	32754825	32754825	T	G	Missense_Mutation	p.I239M	1
CNOT10	UCS	chr3	32778914	32778914	T	C	Silent		1
CNOT10	ESCA	chr3	32737174	32737174	C	G	Silent		1
CNOT10	LIHC	chr3	32801028	32801028	A	C	Missense_Mutation	p.K558N	1
CNOT10	LIHC	chr3	32746439	32746439	A	-	Frame_Shift_Del	p.Q85fs	1
CNOT10	SKCM	chr3	32776307	32776307	G	A	Silent	p.S511S	1
CNOT10	LUAD	chr3	32754764	32754764	A	G	Missense_Mutation	p.Y159C	1
CNOT10	BLCA	chr3	32806176	32806183	GGTAAGCG	-	Frame_Shift_Del		1
CNOT10	HNSC	chr3	32758664	32758665	-	T	Frame_Shift_Ins	p.I227fs	1
CNOT10	READ	chr3	32761648	32761648	A	G	Missense_Mutation	p.R323G	1
CNOT10	STAD	chr3	32804346	32804346	C	T	Nonsense_Mutation	p.Q611*	1
CNOT10	UCEC	chr3	32811430	32811430	G	T	Missense_Mutation	p.A746S	1
CNOT10	UCS	chr3	32778914	32778914	T	C	Silent	p.H569H	1
CNOT10	LIHC	chr3	32769180	32769180	C	-	Frame_Shift_Del	p.P345fs	1
CNOT10	SKCM	chr3	32754731	32754731	C	T	Missense_Mutation	p.A208V	1
CNOT10	KIRC	chr3	32750281	32750281	T	A	Silent	p.G193G	1
CNOT10	MESO	chr3	32769215	32769215	G	C	Missense_Mutation		1
CNOT10	STAD	chr3	32814971	32814971	G	T	Missense_Mutation	p.Q761H	1
CNOT10	BLCA	chr3	32745388	32745388	A	G	Silent		1
CNOT10	CESC	chr3	32776386	32776386	G	C	Missense_Mutation	p.D478H	1
CNOT10	LIHC	chr3	32811404	32811404	A	G	Missense_Mutation		1
CNOT10	SARC	chr3	32737222	32737222	G	T	Missense_Mutation		1
CNOT10	STAD	chr3	32804301	32804301	C	G	Missense_Mutation	p.P596A	1
CNOT10	UCEC	chr3	32811409	32811409	C	-	Frame_Shift_Del	p.P739fs	1
CNOT10	ESCA	chr3	32769327	32769327	C	T	Missense_Mutation	p.R454W	1
CNOT10	LIHC	chr3	32806301	32806301	G	-	Splice_Site	p.Q668_splice	1
CNOT10	SKCM	chr3	32800955	32800955	C	T	Missense_Mutation	p.S594F	1
CNOT10	BLCA	chr3	32761640	32761640	A	G	Missense_Mutation	p.E260G	1
CNOT10	MESO	chr3	32769215	32769215	G	C	Missense_Mutation	p.E356D	1
CNOT10	STAD	chr3	32806268	32806268	C	T	Silent	p.S717S	1
CNOT10	CESC	chr3	32776386	32776386	G	C	Missense_Mutation	p.D538H	1
CNOT10	SARC	chr3	32754805	32754805	G	T	Missense_Mutation		1
CNOT10	THCA	chr3	32758702	32758702	C	A	Silent		1

Copy number variation (CNV) of CNOT10
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CNOT10
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
94167	N/A	BE837802	ACTN1	chr14	69431376	-	CNOT10	chr3	32806208	-
94167	Non-Cancer	13N	C2orf70	chr2	26785554	+	CNOT10	chr3	32800949	+
86765	Non-Cancer	TCGA-IN-8462-11A	CNOT10	chr3	32778982	+	ASAP1	chr8	131200429	-
90685	N/A	EC560858	CNOT10	chr3	32757352	+	BDNF-AS	chr11	27538131	-
101753	STAD	TCGA-CD-A4MH	CNOT10	chr3	32778982	+	CACNA2D4	chr12	1955855	-
42487	ESCA	TCGA-LN-A49V	CNOT10	chr3	32758729	+	CMTM7	chr3	32493883	+
42487	ESCA	TCGA-LN-A49V	CNOT10	chr3	32758729	+	CMTM7	chr3	32493884	+
42487	SKCM	TCGA-FS-A1ZF-06A	CNOT10	chr3	32769362	+	CMTM7	chr3	32524236	+
94167	PRAD	TCGA-KK-A7B1-01A	GPD1L	chr3	32188226	+	CNOT10	chr3	32750162	+
94167	STAD	TCGA-FP-8210-01A	GPR65	chr14	88471566	+	CNOT10	chr3	32800950	+
94167	N/A	AW937598	HUNK	chr21	33312033	-	CNOT10	chr3	32810076	+
94167	N/A	EI790451	LITAF	chr16	11652225	-	CNOT10	chr3	32812659	-
94167	OV	TCGA-57-1994	SUGT1	chr13	53238192	+	CNOT10	chr3	32800949	+
94168	TGCT	TCGA-XY-A8S3-01B	TRIM71	chr3	32860424	+	CNOT10	chr3	32814949	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	CNOT10	0.000692258470618943	0.019
SARC	CNOT10	0.00452901750171543	0.12
BLCA	CNOT10	0.00906297328580405	0.24
ESCA	CNOT10	0.011534541889899	0.29
STAD	CNOT10	0.0131760184418787	0.32
KIRC	CNOT10	0.0181154995156666	0.42
LIHC	CNOT10	0.0191008153128516	0.42

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	CNOT10	0.000576606309480125	0.019
LUAD	CNOT10	0.00142455099519627	0.046
LUSC	CNOT10	0.0100516953370907	0.3
GBM	CNOT10	0.037185059076044	1
LAML	CNOT10	0.0289091181965786	0.84
THYM	CNOT10	0.00240321917710592	0.074

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source