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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PARS2 (NCBI Gene ID:25973)

Gene Summary

Gene Summary

Gene Information	Gene Name: PARS2
	Gene ID: 25973
	Gene Symbol	PARS2
	Gene ID	25973
	Gene Name	prolyl-tRNA synthetase 2, mitochondrial
	Synonyms	EIEE75\|MT-PRORS\|proRS
	Cytomap	1p32.3
	Type of Gene	protein-coding
	Description	probable proline--tRNA ligase, mitochondrialproline tRNA ligase 2, mitochondrial (putative)prolyl-tRNA synthetase 2, mitochondrial (putative)
	Modification date	20200313
	UniProtAcc	Q7L3T8

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006418	tRNA aminoacylation for protein translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PARS2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'PARS2[title] AND translation [title] AND human.'

Gene	Title	PMID
PARS2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	PARS2	1.16452168188224	0.000471815001219511
BLCA	PARS2	-2.53947468245316	0.002838134765625
PRAD	PARS2	-1.46158282673459	0.0436765184075403
LUAD	PARS2	-3.49187010929807	1.06715530949094e-10
LUSC	PARS2	-2.93653902690081	3.1117120779415e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	PARS2	hsa-miR-185-5p	93	-0.537051184110008	0.00125010895313018

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
KIRP	PARS2	3	2	0.0386005513737219	0.612164938080495	0.562185505206867	-0.333206581384009	-0.240994616143435

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PARS2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
UVM	Epifactor	PARS2	NOC2L	0.854256894	7.24E-24
UVM	TSG	PARS2	DNAJC11	0.859018947	2.18E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	PARS2	LARS2	-3.14243034518345	0.00019507110118866
STAD	PARS2	YARS	-6.49411565641968	0.000280400272458792
KIRP	PARS2	EARS2	2.04485161641576	0.000364991836249828
BRCA	PARS2	QARS	-4.19270554058168	0.00045278023754438
LUSC	PARS2	LARS	-1.72121981954749	0.000480107205471704
HNSC	PARS2	YARS	1.29642872422682	0.000481783007217019
THCA	PARS2	LARS2	1.46480152873302	0.000495104848866816
STAD	PARS2	AARS	-1.37044043826934	0.000657554250210524
STAD	PARS2	EPRS	-1.48171581324647	0.000789262883452143
THCA	PARS2	QARS	-1.4601543520666	0.00171161769998529
CHOL	PARS2	MARS	-4.58890181072108	0.00390625
STAD	PARS2	IARS2	-1.36774073274524	0.0324882394634187
LIHC	PARS2	LARS	-1.57612943170265	1.09871251804152e-08
BRCA	PARS2	LARS2	-5.48583270161281	1.12177735729832e-06
LUAD	PARS2	LARS	-1.89171706205171	1.25525807323939e-06
THCA	PARS2	YARS	-1.52851760350795	1.38467683131598e-09
LIHC	PARS2	EPRS	-7.10731017811505	2.28054594243154e-08
BRCA	PARS2	IARS2	1.50870900515201	2.53632294696759e-14
LUAD	PARS2	LARS2	-1.17851720308655	2.81164525558733e-06
KICH	PARS2	YARS	-2.00632816869948	2.98023223876953e-07
LUSC	PARS2	EARS2	-4.79437223180067	3.23227619897643e-09
PRAD	PARS2	QARS	1.84374784424986	3.33417295851411e-06
BRCA	PARS2	YARS	-2.58863291399932	3.63754942015711e-21
LUAD	PARS2	EARS2	-4.660053370012	3.79251210274868e-11
BLCA	PARS2	EARS2	-4.74352280775662	3.814697265625e-06
KICH	PARS2	LARS2	1.44112931619469	4.17232513427734e-06
STAD	PARS2	EARS2	-1.69983591205674	4.39747236669064e-05
LUAD	PARS2	AARS	-6.1139400689607	4.40386642176516e-08
BRCA	PARS2	MARS	-2.42525133735396	4.72741245870012e-27
LIHC	PARS2	MARS	-3.13394077995853	7.36800472650994e-09
KIRP	PARS2	MARS	-1.35870938193596	7.40401446819306e-05
PRAD	PARS2	EPRS	-1.76339127457265	9.52775218277559e-05
STAD	PARS2	NARS2	-1.47625969382721	9.99853946268559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PARS2

PRKAA2, ICT1, LMX1B, DLD, HSPB9, EPRS, FOXM1, EGLN3, RECQL4, DHX9, DLAT, HSD17B4, ILF3, LRPPRC, ALDH16A1, CORO1B, LARS, PDHX, RARS, XRCC6, PLEKHA4, SH2D3C, PRKAA1, PRKAB1, PRKAB2, PRKAG1, HSCB, BRD1, DDRGK1, DSE, IGKV1D-13, DNAJB11, NQO2, ZC4H2, YARS2, MRPS24, EMILIN1, STIM2, LPCAT1, NDUFS7, AK4, IL25,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PARS2	chr1	55223168	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
PARS2	chr1	55223190	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
PARS2	chr1	55223197	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
PARS2	chr1	55223262	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
PARS2	chr1	55223524	G	C	single_nucleotide_variant	Benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223530	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223536	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223581	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223658	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223677	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223681	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55223704	A	AG	Duplication	Pathogenic	Developmental_and_epileptic_encephalopathy,_75	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PARS2	chr1	55223706	G	A	single_nucleotide_variant	Uncertain_significance	Developmental_and_epileptic_encephalopathy,_75	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55223719	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223721	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55223744	G	C	single_nucleotide_variant	Uncertain_significance	Developmental_and_epileptic_encephalopathy,_75\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55223760	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55223970	G	A	single_nucleotide_variant	Likely_pathogenic	Inborn_genetic_diseases	SO:0001587\|nonsense	SO:0001587\|nonsense
PARS2	chr1	55223992	G	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223995	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55223999	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Developmental_and_epileptic_encephalopathy,_75\|Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224129	T	C	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224131	T	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224228	C	T	single_nucleotide_variant	Uncertain_significance	Developmental_and_epileptic_encephalopathy,_75	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224231	G	C	single_nucleotide_variant	Uncertain_significance	Developmental_and_epileptic_encephalopathy,_75	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224275	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224279	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224346	C	T	single_nucleotide_variant	Benign/Likely_benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55224452	C	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PARS2	chr1	55224495	C	T	single_nucleotide_variant	Uncertain_significance	Developmental_and_epileptic_encephalopathy,_75	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224512	T	C	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224552	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	PARS2-related_disorder\|Developmental_and_epileptic_encephalopathy,_75\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224596	A	G	single_nucleotide_variant	Uncertain_significance	Developmental_and_epileptic_encephalopathy,_75	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224626	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224685	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PARS2	chr1	55224704	C	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224722	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224726	CTCT	C	Microsatellite	Benign	not_specified	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PARS2	chr1	55224751	C	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224773	A	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PARS2	chr1	55224849	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
PARS2	chr1	55224861	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
PARS2	chr1	55225016	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PARS2	chr1	55225025	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PARS2	chr1	55225029	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PARS2	chr1	55225079	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PARS2	chr1	55225089	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PARS2	chr1	55230114	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PARS2	chr1	55230123	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PARS2	chr1	55230135	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
PARS2	chr1	55230227	G	A	single_nucleotide_variant	Benign	not_provided
PARS2	chr1	55230233	T	C	single_nucleotide_variant	Benign	not_provided
PARS2	chr1	55230335	G	C	single_nucleotide_variant	Benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PARS2	BRCA	chr1	55224704	55224704	C	T	Missense_Mutation	p.R44H	4
PARS2	UCEC	chr1	55224179	55224179	G	A	Missense_Mutation	p.A219V	3
PARS2	LIHC	chr1	55223846	55223846	C	T	Missense_Mutation		3
PARS2	UCEC	chr1	55224666	55224666	G	A	Missense_Mutation	p.L57F	3
PARS2	LIHC	chr1	55223846	55223846	C	T	Missense_Mutation	p.G330D	3
PARS2	HNSC	chr1	55224719	55224719	C	T	Missense_Mutation	p.R39H	3
PARS2	PAAD	chr1	55224511	55224511	C	A	Missense_Mutation	p.E108D	3
PARS2	BLCA	chr1	55223794	55223794	G	C	Missense_Mutation		3
PARS2	PAAD	chr1	55223794	55223794	G	A	Silent	p.I347I	3
PARS2	SKCM	chr1	55223545	55223545	G	A	Silent	p.Y430Y	2
PARS2	HNSC	chr1	55224789	55224789	T	A	Missense_Mutation	p.T16S	2
PARS2	SKCM	chr1	55224465	55224465	G	A	Missense_Mutation	p.P124S	2
PARS2	SKCM	chr1	55224298	55224298	G	A	Silent	p.F179F	2
PARS2	SKCM	chr1	55224058	55224058	G	A	Silent	p.F259F	2
PARS2	UCEC	chr1	55223427	55223427	T	C	Missense_Mutation	p.T470A	2
PARS2	PAAD	chr1	55224511	55224511	C	A	Missense_Mutation		2
PARS2	UCEC	chr1	55223619	55223619	C	T	Missense_Mutation	p.G406R	2
PARS2	UCEC	chr1	55223653	55223653	G	A	Silent	p.Y394	2
PARS2	UCEC	chr1	55223923	55223923	G	A	Silent	p.G304	2
PARS2	PRAD	chr1	55224300	55224300	A	G	Missense_Mutation	p.F179L	2
PARS2	KIRC	chr1	55224207	55224207	A	G	Missense_Mutation	p.Y210H	2
PARS2	UCEC	chr1	55223974	55223974	C	T	Silent	p.L287	2
PARS2	KIRP	chr1	55224781	55224781	G	T	Missense_Mutation	p.S18R	2
PARS2	KIRP	chr1	55224725	55224725	C	A	Missense_Mutation		1
PARS2	THCA	chr1	55224024	55224024	C	A	Missense_Mutation		1
PARS2	BLCA	chr1	55224681	55224681	G	A	Missense_Mutation	p.R52W	1
PARS2	LUSC	chr1	55224180	55224180	C	A	Missense_Mutation	p.A219S	1
PARS2	HNSC	chr1	55224675	55224675	C	G	Missense_Mutation		1
PARS2	LGG	chr1	55224353	55224353	G	A	Missense_Mutation	p.A161V	1
PARS2	THCA	chr1	55224498	55224498	C	A	Missense_Mutation		1
PARS2	UCEC	chr1	55223474	55223474	G	C	Missense_Mutation	p.T454S	1
PARS2	BLCA	chr1	55224597	55224597	T	A	Missense_Mutation	p.I80F	1
PARS2	LUSC	chr1	55224198	55224198	C	G	Missense_Mutation	p.D213H	1
PARS2	LGG	chr1	55224353	55224353	G	A	Missense_Mutation		1
PARS2	OV	chr1	54996505	54996505	C	T	Silent		1
PARS2	HNSC	chr1	55224675	55224675	C	G	Missense_Mutation	p.D54H	1
PARS2	COAD	chr1	55223570	55223570	A	C	Missense_Mutation	p.L422R	1
PARS2	OV	chr1	55223580	55223580	C	A	Nonsense_Mutation	p.G419*	1
PARS2	HNSC	chr1	55224213	55224213	C	G	Missense_Mutation	p.D208H	1
PARS2	BLCA	chr1	55224036	55224036	C	T	Missense_Mutation		1
PARS2	ESCA	chr1	55224664	55224664	G	T	Silent	p.L57	1
PARS2	SKCM	chr1	55224238	55224238	G	A	Silent	p.L199L	1
PARS2	BLCA	chr1	55223755	55223755	A	G	Silent		1
PARS2	LIHC	chr1	55223911	55223911	C	-	Frame_Shift_Del	p.G308fs	1
PARS2	ESCA	chr1	55224664	55224664	G	T	Silent		1
PARS2	HNSC	chr1	55223963	55223963	T	C	Missense_Mutation	p.N291S	1
PARS2	SKCM	chr1	55223605	55223605	C	T	Silent	p.L410L	1
PARS2	LIHC	chr1	55223616	55223616	C	-	Frame_Shift_Del	p.E407fs	1
PARS2	ESCA	chr1	55224664	55224664	G	T	Silent	p.L57L	1
PARS2	KICH	chr1	55224826	55224826	C	T	Silent		1
PARS2	SKCM	chr1	55224184	55224184	C	T	Silent	p.E217E	1
PARS2	BLCA	chr1	55224681	55224681	G	A	Missense_Mutation		1
PARS2	LUAD	chr1	55224317	55224317	G	C	Missense_Mutation	p.S173C	1
PARS2	GBM	chr1	55224003	55224003	A	T	Missense_Mutation	p.F278I	1
PARS2	SKCM	chr1	55224553	55224553	G	A	Silent	p.T94T	1
PARS2	BLCA	chr1	55224036	55224036	C	T	Missense_Mutation	p.E267K	1
PARS2	LUAD	chr1	55223833	55223833	C	A	Silent	p.L334L	1
PARS2	HNSC	chr1	55224213	55224213	C	G	Missense_Mutation		1
PARS2	SARC	chr1	55223910	55223910	G	T	Missense_Mutation		1
PARS2	KIRP	chr1	55224237	55224237	G	T	Missense_Mutation	p.R200S	1
PARS2	SKCM	chr1	55223872	55223872	G	A	Silent	p.F321F	1
PARS2	BLCA	chr1	55223755	55223755	A	G	Silent	p.C360C	1
PARS2	LUSC	chr1	55223696	55223696	C	T	Missense_Mutation	p.G380D	1
PARS2	HNSC	chr1	55223963	55223963	T	C	Missense_Mutation		1
PARS2	SARC	chr1	55223944	55223944	G	T	Silent		1
PARS2	THCA	chr1	55224131	55224131	T	C	Missense_Mutation		1
PARS2	BLCA	chr1	55223794	55223794	G	C	Missense_Mutation	p.I347M	1
PARS2	LUSC	chr1	55224731	55224731	C	T	Missense_Mutation	p.R35K	1
PARS2	HNSC	chr1	55224789	55224789	T	A	Missense_Mutation		1
PARS2	SKCM	chr1	55223619	55223619	C	A	Missense_Mutation	p.G406W	1

Copy number variation (CNV) of PARS2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PARS2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	PARS2	0.000395650809604887	0.011
KIRP	PARS2	0.00520151215826661	0.14
LUAD	PARS2	0.039292540968714	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	PARS2	0.0478539433624809	1
THCA	PARS2	0.000119957889402347	0.004
BRCA	PARS2	0.000850201864968705	0.027
UVM	PARS2	0.018058862105548	0.54
UCEC	PARS2	0.0133105958057424	0.41
PCPG	PARS2	0.0434402931972411	1
THYM	PARS2	0.0468016217648223	1
HNSC	PARS2	0.0204941772011217	0.59

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0205710	Alpers Syndrome (disorder)	2	GENOMICS_ENGLAND