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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: LTN1 (NCBI Gene ID:26046)

Gene Summary

Gene Summary

Gene Information	Gene Name: LTN1
	Gene ID: 26046
	Gene Symbol	LTN1
	Gene ID	26046
	Gene Name	listerin E3 ubiquitin protein ligase 1
	Synonyms	C21orf10\|C21orf98\|RNF160\|ZNF294
	Cytomap	21q21.3
	Type of Gene	protein-coding
	Description	E3 ubiquitin-protein ligase listerinRING-type E3 ubiquitin transferase listerinring finger protein 160zinc finger protein 294
	Modification date	20200313
	UniProtAcc	O94822

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
LTN1	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'LTN1[title] AND translation [title] AND human.'

Gene	Title	PMID
LTN1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000361371	30304791	30304986	In-frame
ENST00000361371	30307430	30307651	Frame-shift
ENST00000361371	30315988	30316226	Frame-shift
ENST00000361371	30329653	30329798	Frame-shift
ENST00000361371	30338186	30338228	In-frame
ENST00000361371	30343592	30343766	In-frame
ENST00000361371	30353440	30353621	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000361371	30304791	30304986	7702	4956	5150	1766	1625	1690
ENST00000361371	30338186	30338228	7702	2202	2243	1766	707	721
ENST00000361371	30343592	30343766	7702	891	1064	1766	270	328

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with LTN1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	LTN1	RPL3	2.43523389101044	0.00016188295558095
STAD	LTN1	ZNF598	1.90805357051412	0.000433447770774365
LIHC	LTN1	HBS1L	-3.51830003681254	0.000568486322514105
LIHC	LTN1	ZNF598	-2.14881301213792	0.00182077236082954
LUAD	LTN1	HBS1L	-3.79049220477362	0.00334247187092709
ESCA	LTN1	TCF25	2.00435474876057	0.0048828125
COAD	LTN1	HBS1L	-2.33101802408262	0.0140064954757691
THCA	LTN1	RPL31	1.09436372419291	0.0152379297688856
BRCA	LTN1	RPL23A	-1.00708839787202	0.0188078315893149
PRAD	LTN1	RPL31	1.37417394483053	0.0209655998648434
ESCA	LTN1	ZNF598	1.25106219261408	0.0244140625
ESCA	LTN1	RPL3	1.12882976357497	0.0322265625
BLCA	LTN1	VCP	1.64346607685126	0.040130615234375
KICH	LTN1	VCP	-1.0767074679478	0.0421501994132996
HNSC	LTN1	HBS1L	-1.05185243210432	0.0462444565380338
KIRP	LTN1	RPL23A	-1.52936455976751	1.2875534594059e-06
KIRC	LTN1	TCF25	-1.15044290242785	1.45266993448751e-06
BRCA	LTN1	ZNF598	-1.1638047490822	1.46241900078771e-11
LUAD	LTN1	VCP	-3.53792153271573	2.3648912015911e-05
THCA	LTN1	UBR1	-3.07118213716464	2.40972799633227e-05
LUAD	LTN1	ZNF598	-2.12729389726251	3.16320496270304e-09
PRAD	LTN1	VCP	1.47137253545938	3.48152859299693e-07
PRAD	LTN1	ZNF598	-1.44121746895011	3.48452906745071e-06
KIRP	LTN1	ZNF598	-2.13529054966028	4.6566128730774e-09
BRCA	LTN1	TCF25	2.20042599781085	5.84048483443751e-11
LUAD	LTN1	RPL23A	-2.22526108535187	7.13242533835451e-05
HNSC	LTN1	ZNF598	1.19099633730873	8.09852713246075e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with LTN1

UBE2D2, IRF7, TIRAP, TMEM173, UBC, IQCB1, MMS19, EGFR, HES4, SHFM1, BAG1, NEMF, SPACA1, KIR2DS2, CA14, HLA-B, CD244, SLAMF1, B3GALT2, TGOLN2, ALDH3A2, PRPF19, RPA1, RPA3, NTRK1, DHCR7, FEN1, HPX, KIF2A, NPAT, SP100, TAP1, CTDP1, PLD3, CHMP2B, MAPK3, PTPN1, XRCC3, CCDC93, UGGT1, PARD6B, MBOAT1, CLSPN, CEP97, ILKAP, PNPT1, KIF18B, TET3, Evpl, Nek2, Cul1, Shoc2, Sgol2, Trappc8, Cenpq, Tor1aip1, SEC61B, SSR1, RPL6, DUSP9, NPY2R, CD79B, SIGLECL1, VASN, FAM174A, EPHA1, LAMP3, CHRM3, RNF19B, DKKL1, PTPRN, K8.1, CFTR, CENPP, CHMP2A, EIF6, EXOSC4, LTN1, MCM3AP, POLE, SAP18, SNAPC1, TUBB, WDR61, RNF11, UBE2L3, ESR2, UBE2D1, MYC, ACACA, PCCA, ACACB, FAM21A, DVL1, UBE3C, PC, MKL2, LRRC49, NICN1, RPS6KA1, TPGS1, TPGS2, TRMT2A, TYW3, MYH10, MYH9, DIMT1, MYO5B, PFKFB3, HIGD1A, OTUD4, NOP14, GTF2B, JAK1, E2F7, IVNS1ABP, MAP2K7, TAF4, PPM1B, FILIP1L, MRPL4, MYH14, MRPS30, MRPL24, MRPL37, MRPL48, MRPL50, MRPL15, MRPL13, MRPL41, MRPL2, MRPL30, MRPL28, MRPL55, MRPL19, DOCK4, PRMT5, KIAA1429, RPS6KA3, RPS6KA2, RPS6KA6, KRAS, CD74, BCL2L14, P2RY6, SLC15A3, UNC93B1, SNRNP70, DUSP2, PTPMT1, PTPRR, CLUAP1, TRIM28, PLEKHA4, M, ORF7a, NPM1, nsp2, nsp3, ESR1, LRRC31, BRD1, TRIM66, ASXL1, DENND6A, KRT8, C19orf38, GPR182, P2RY10, FCER1A, CD40, IL2RA, KCNMB3, KIR2DL4, TMEM9, LRRC25, DGCR2, GPR17, C3orf18, FCGR3A, NPTN, CD226, HCST, IGHM, OPALIN, SLFN11, ZRANB1, TMPRSS11B, TMPRSS4,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
LTN1	chr21	30303494	AT	A	Deletion	Uncertain_significance	Neurodevelopmental_disorder	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
LTN1	chr21	30330812	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
LTN1	chr21	30339314	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
LTN1	chr21	30339427	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
LTN1	chr21	30343713	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
LTN1	SKCM	chr21	30365209	30365209	G	A	Missense_Mutation	p.S19F	7
LTN1	ESCA	chr21	30339206	30339206	T	-	Frame_Shift_Del	p.N536fs	5
LTN1	LUAD	chr21	30304987	30304987	C	A	Splice_Site		4
LTN1	HNSC	chr21	30318479	30318479	G	A	Silent	p.F1206F	3
LTN1	LIHC	chr21	30354673	30354673	A	G	Silent		3
LTN1	LIHC	chr21	30318207	30318207	T	C	Silent		3
LTN1	LIHC	chr21	30357163	30357163	G	T	Silent		3
LTN1	CHOL	chr21	30332965	30332965	C	T	Missense_Mutation		3
LTN1	STAD	chr21	30342949	30342949	A	G	Missense_Mutation		2
LTN1	UCEC	chr21	30302787	30302787	G	A	Missense_Mutation	p.R1762C	2
LTN1	CESC	chr21	30329098	30329098	T	A	Missense_Mutation		2
LTN1	LIHC	chr21	30357184	30357184	T	-	Frame_Shift_Del	p.K135fs	2
LTN1	UCEC	chr21	30339387	30339387	C	A	Missense_Mutation	p.D476Y	2
LTN1	KICH	chr21	30307615	30307615	G	A	Missense_Mutation	p.A1610V	2
LTN1	STAD	chr21	30307435	30307435	A	G	Missense_Mutation		2
LTN1	UCEC	chr21	30303603	30303603	G	A	Silent	p.N1704	2
LTN1	UCEC	chr21	30342917	30342917	T	G	Missense_Mutation	p.K378Q	2
LTN1	CHOL	chr21	30332965	30332965	C	T	Missense_Mutation	p.E743K	2
LTN1	KICH	chr21	30331996	30331996	C	T	Missense_Mutation	p.V839I	2
LTN1	UCS	chr21	30358482	30358482	C	A	Missense_Mutation	p.R108I	2
LTN1	STAD	chr21	30353449	30353449	C	T	Missense_Mutation		2
LTN1	UCEC	chr21	30303645	30303645	C	T	Splice_Site	e29-1	2
LTN1	CESC	chr21	30358482	30358482	C	A	Missense_Mutation		2
LTN1	LIHC	chr21	30316753	30316753	A	-	Frame_Shift_Del	p.S1312fs	2
LTN1	UCEC	chr21	30353522	30353522	C	A	Missense_Mutation	p.E243D	2
LTN1	SARC	chr21	30303544	30303544	C	T	Missense_Mutation		2
LTN1	UCS	chr21	30302792	30302799	AGTGGACA	-	Frame_Shift_Del	p.CPL1758fs	2
LTN1	ESCA	chr21	30342970	30342971	-	A	Frame_Shift_Ins	p.Y406fs	2
LTN1	PRAD	chr21	30339290	30339290	T	G	Missense_Mutation	p.D554A	2
LTN1	STAD	chr21	30353596	30353596	C	T	Missense_Mutation		2
LTN1	UCEC	chr21	30315604	30315604	A	T	Missense_Mutation	p.D1425E	2
LTN1	LUAD	chr21	30339448	30339448	C	T	Silent	p.Q455Q	2
LTN1	UCEC	chr21	30357117	30357117	T	C	Missense_Mutation	p.T158A	2
LTN1	SARC	chr21	30358501	30358501	C	A	Missense_Mutation		2
LTN1	UCEC	chr21	30316192	30316192	C	A	Missense_Mutation	p.Q1339H	2
LTN1	UCEC	chr21	30357196	30357196	T	G	Missense_Mutation	p.K131N	2
LTN1	SARC	chr21	30316157	30316157	G	A	Missense_Mutation		2
LTN1	ESCA	chr21	30338185	30338185	A	G	Splice_Site		2
LTN1	LIHC	chr21	30354673	30354673	A	G	Silent	p.L198L	2
LTN1	UCEC	chr21	30316797	30316797	C	T	Missense_Mutation	p.G1297D	2
LTN1	CESC	chr21	30357145	30357145	C	T	Missense_Mutation		2
LTN1	UCEC	chr21	30358476	30358476	A	C	Missense_Mutation	p.F110C	2
LTN1	PAAD	chr21	30338786	30338786	T	G	Missense_Mutation		2
LTN1	SKCM	chr21	30316198	30316198	G	A	Silent	p.S1337S	2
LTN1	SARC	chr21	30357066	30357066	G	T	Missense_Mutation		2
LTN1	UCEC	chr21	30316872	30316872	A	G	Missense_Mutation	p.L1272P	2
LTN1	UCEC	chr21	30359102	30359102	G	A	Nonsense_Mutation	p.R66*	2
LTN1	PAAD	chr21	30359125	30359125	T	G	Missense_Mutation		2
LTN1	SKCM	chr21	30307468	30307468	G	A	Missense_Mutation	p.S1613F	2
LTN1	HNSC	chr21	30318479	30318479	G	A	Silent		2
LTN1	UCEC	chr21	30325604	30325604	A	G	Silent	p.N1058	2
LTN1	HNSC	chr21	30357237	30357237	C	T	Missense_Mutation	p.D118N	2
LTN1	UCEC	chr21	30359208	30359208	T	A	Silent	p.N53Y	2
LTN1	STAD	chr21	30341860	30341860	A	-	Frame_Shift_Del	p.E460fs	2
LTN1	LIHC	chr21	30343736	30343736	C	A	Missense_Mutation		2
LTN1	LIHC	chr21	30316848	30316848	A	-	Frame_Shift_Del	p.L1280fs	2
LTN1	UCEC	chr21	30329187	30329187	C	G	Missense_Mutation	p.K992N	2
LTN1	HNSC	chr21	30339475	30339475	G	C	Silent	p.L446L	2
LTN1	UCEC	chr21	30359221	30359221	G	A	Missense_Mutation	p.A26V	2
LTN1	SKCM	chr21	30338844	30338844	G	A	Missense_Mutation	p.P657S	2
LTN1	TGCT	chr21	30341891	30341891	A	G	Missense_Mutation		2
LTN1	GBM	chr21	30359239	30359239	C	T	Missense_Mutation	p.R66Q	2
LTN1	BLCA	chr21	30331900	30331900	C	A	Missense_Mutation		2
LTN1	LIHC	chr21	30339411	30339411	C	-	Frame_Shift_Del	p.E468fs	2
LTN1	UCEC	chr21	30332842	30332842	T	G	Missense_Mutation	p.N784H	2
LTN1	STAD	chr21	30316743	30316743	A	T	Missense_Mutation		2
LTN1	LIHC	chr21	30357153	30357153	T	-	Frame_Shift_Del	p.S146fs	2
LTN1	UCEC	chr21	30339154	30339154	T	G	Missense_Mutation	p.E553D	2
LTN1	CHOL	chr21	30339206	30339206	T	A	Missense_Mutation	p.N582I	2
LTN1	STAD	chr21	30316753	30316753	A	-	Frame_Shift_Del	p.S1358fs	2
LTN1	READ	chr21	30324491	30324491	C	T	Missense_Mutation	p.R1158K	1
LTN1	SKCM	chr21	30316752	30316752	G	A	Missense_Mutation	p.S1358F	1
LTN1	GBM	chr21	30307586	30307586	C	A	Missense_Mutation		1
LTN1	LGG	chr21	30338725	30338725	C	T	Missense_Mutation	p.M742I	1
LTN1	LIHC	chr21	30339226	30339226	C	T	Silent	p.L575L	1
LTN1	LUAD	chr21	30308959	30308959	G	C	Missense_Mutation	p.H1515D	1
LTN1	BLCA	chr21	30338214	30338214	C	A	Missense_Mutation		1
LTN1	LGG	chr21	30330708	30330708	C	A	Missense_Mutation		1
LTN1	LUAD	chr21	30342994	30342994	C	A	Missense_Mutation	p.G352V	1
LTN1	BLCA	chr21	30338207	30338207	G	A	Missense_Mutation		1
LTN1	CHOL	chr21	30332965	30332965	C	T	Missense_Mutation	p.E789K	1
LTN1	SARC	chr21	30339073	30339073	G	T	Silent		1
LTN1	SKCM	chr21	30329731	30329731	G	A	Missense_Mutation	p.L939F	1
LTN1	SKCM	chr21	30339281	30339281	G	A	Missense_Mutation	p.S511F	1
LTN1	STAD	chr21	30339315	30339315	C	T	Missense_Mutation	p.A546T	1
LTN1	HNSC	chr21	30339475	30339475	G	C	Silent		1
LTN1	SKCM	chr21	30329142	30329142	C	T	Missense_Mutation	p.M1007I	1
LTN1	STAD	chr21	30330717	30330717	T	A	Missense_Mutation	p.D959V	1
LTN1	THYM	chr21	30316039	30316039	G	T	Silent		1
LTN1	LIHC	chr21	30338713	30338713	T	-	Frame_Shift_Del	p.K700fs	1
LTN1	UCS	chr21	30358482	30358482	C	A	Missense_Mutation	p.R154I	1
LTN1	OV	chr21	30303491	30303491	G	T	Missense_Mutation	p.H1742N	1
LTN1	BLCA	chr21	30316094	30316094	T	C	Missense_Mutation	p.K1418R	1
LTN1	ESCA	chr21	30339206	30339207	TT	-	Frame_Shift_Del	p.N582fs	1
LTN1	PAAD	chr21	30359125	30359125	T	G	Missense_Mutation	p.D58A	1
LTN1	SARC	chr21	30303544	30303544	C	T	Missense_Mutation	p.G1770D	1
LTN1	READ	chr21	30343625	30343625	C	T	Missense_Mutation	p.E364K	1
LTN1	SKCM	chr21	30304892	30304892	G	A	Missense_Mutation	p.P1703L	1
LTN1	GBM	chr21	30308879	30308879	G	T	Missense_Mutation		1
LTN1	LGG	chr21	30358538	30358538	G	-	Frame_Shift_Del	p.M136fs	1
LTN1	LIHC	chr21	30341864	30341864	A	C	Missense_Mutation	p.F458C	1
LTN1	LUAD	chr21	30315659	30315659	C	A	Splice_Site		1
LTN1	BLCA	chr21	30338215	30338215	C	G	Missense_Mutation		1
LTN1	CESC	chr21	30342935	30342935	G	C	Missense_Mutation		1
LTN1	HNSC	chr21	30359144	30359144	G	C	Missense_Mutation	p.Q52E	1
LTN1	LGG	chr21	30343762	30343762	C	T	Missense_Mutation		1
LTN1	LIHC	chr21	30316046	30316046	G	-	Frame_Shift_Del	p.P1388fs	1
LTN1	LUAD	chr21	30316856	30316856	G	T	Missense_Mutation	p.S1277R	1
LTN1	BLCA	chr21	30329695	30329695	C	T	Missense_Mutation		1
LTN1	SARC	chr21	30343633	30343633	G	T	Missense_Mutation		1
LTN1	SKCM	chr21	30318484	30318484	G	A	Missense_Mutation	p.L1205F	1
LTN1	STAD	chr21	30309004	30309004	A	G	Missense_Mutation	p.S1546P	1
LTN1	SKCM	chr21	30304892	30304892	G	A	Missense_Mutation	p.P1657L	1
LTN1	STAD	chr21	30302779	30302779	C	T	Silent	p.T1810T	1
LTN1	THYM	chr21	30329258	30329258	G	T	Missense_Mutation		1
LTN1	LIHC	chr21	30324545	30324545	T	-	Frame_Shift_Del	p.K1094fs	1
LTN1	OV	chr21	30358518	30358518	G	A	Missense_Mutation	p.T96I	1
LTN1	BLCA	chr21	30307437	30307437	G	T	Silent	p.G1669G	1
LTN1	ESCA	chr21	30339206	30339206	T	-	Frame_Shift_Del	p.N582fs	1
LTN1	PAAD	chr21	30339377	30339377	G	A	Missense_Mutation	p.T479I	1
LTN1	SARC	chr21	30316157	30316157	G	A	Missense_Mutation	p.T1397M	1
LTN1	READ	chr21	30343704	30343704	T	G	Missense_Mutation	p.K337N	1
LTN1	SKCM	chr21	30318484	30318484	G	A	Missense_Mutation	p.L1251F	1
LTN1	SKCM	chr21	30325549	30325549	A	C	Missense_Mutation	p.L1077V	1
LTN1	GBM	chr21	30319804	30319804	C	A	Missense_Mutation		1
LTN1	LGG	chr21	30338725	30338725	C	T	Missense_Mutation	p.M696I	1
LTN1	LIHC	chr21	30329699	30329699	C	T	Silent	p.P995P	1
LTN1	LUAD	chr21	30324587	30324587	C	A	Splice_Site		1
LTN1	BLCA	chr21	30365150	30365150	G	C	Missense_Mutation		1
LTN1	LGG	chr21	30354657	30354657	C	G	Missense_Mutation		1
LTN1	LUAD	chr21	30329201	30329201	C	-	Frame_Shift_Del	p.E988fs	1
LTN1	BLCA	chr21	30343595	30343595	C	G	Missense_Mutation		1
LTN1	COAD	chr21	30325699	30325699	C	A	Splice_Site	.	1
LTN1	SKCM	chr21	30365231	30365231	C	T	Missense_Mutation	p.G12R	1
LTN1	STAD	chr21	30338713	30338713	T	-	Frame_Shift_Del	p.V747fs	1
LTN1	SKCM	chr21	30307624	30307624	G	A	Missense_Mutation	p.P1561L	1
LTN1	STAD	chr21	30316743	30316743	A	T	Missense_Mutation	p.I1315N	1
LTN1	ESCA	chr21	30339206	30339207	TT	-	Frame_Shift_Del	p.582_582del	1
LTN1	KIRC	chr21	30339421	30339422	-	A	Frame_Shift_Ins	p.L510fs	1
LTN1	THYM	chr21	30338957	30338957	G	T	Missense_Mutation	p.T665N	1
LTN1	LIHC	chr21	30339272	30339272	C	-	Frame_Shift_Del	p.G514fs	1
LTN1	BLCA	chr21	30307608	30307608	T	C	Silent	p.S1612S	1
LTN1	SARC	chr21	30358501	30358501	C	A	Missense_Mutation	p.V148F	1
LTN1	READ	chr21	30353480	30353480	C	A	Missense_Mutation	p.Q303H	1
LTN1	SKCM	chr21	30330842	30330842	C	T	Silent	p.L917L	1
LTN1	SKCM	chr21	30365230	30365230	C	T	Missense_Mutation	p.G12E	1
LTN1	GBM	chr21	30354691	30354691	C	T	Splice_Site		1
LTN1	LGG	chr21	30342876	30342876	A	C	Silent	p.A391A	1
LTN1	LIHC	chr21	30354673	30354673	A	G	Silent	p.L244L	1
LTN1	BLCA	chr21	30329183	30329183	G	C	Missense_Mutation		1
LTN1	CESC	chr21	30316750	30316750	G	-	Frame_Shift_Del		1
LTN1	HNSC	chr21	30339459	30339459	G	T	Missense_Mutation	p.Q452K	1
LTN1	LGG	chr21	30318165	30318165	C	T	Nonsense_Mutation		1
LTN1	LIHC	chr21	30318235	30318235	T	-	Frame_Shift_Del	p.N1221fs	1
LTN1	LUAD	chr21	30313665	30313666	-	A	Frame_Shift_Ins	p.W1453fs	1
LTN1	BLCA	chr21	30339384	30339384	C	T	Missense_Mutation		1
LTN1	COAD	chr21	30331792	30331792	T	-	Frame_Shift_Del	p.T907fs	1
LTN1	PAAD	chr21	30339377	30339377	G	A	Missense_Mutation		1
LTN1	SKCM	chr21	30316752	30316752	G	A	Missense_Mutation	p.S1312F	1
LTN1	STAD	chr21	30329691	30329691	C	T	Missense_Mutation	p.S998N	1
LTN1	SKCM	chr21	30329112	30329112	G	C	Silent	p.V1017V	1
LTN1	STAD	chr21	30342949	30342949	A	G	Missense_Mutation	p.I367T	1
LTN1	ESCA	chr21	30316101	30316101	C	T	Missense_Mutation	p.D1416N	1
LTN1	KIRC	chr21	30339184	30339184	A	T	Missense_Mutation	p.D589E	1
LTN1	UCEC	chr21	30324503	30324503	G	T	Missense_Mutation	p.P1154Q	1
LTN1	LIHC	chr21	30339388	30339388	T	-	Frame_Shift_Del	p.K475fs	1
LTN1	BLCA	chr21	30339132	30339132	C	G	Missense_Mutation	p.E607Q	1
LTN1	ESCA	chr21	30357050	30357050	G	T	Missense_Mutation	p.P226H	1
LTN1	PRAD	chr21	30308907	30308907	T	C	Missense_Mutation	p.E1532G	1
LTN1	READ	chr21	30332891	30332891	G	T	Missense_Mutation	p.F813L	1
LTN1	SKCM	chr21	30357224	30357224	C	T	Missense_Mutation	p.R168Q	1
LTN1	SKCM	chr21	30308931	30308931	G	A	Missense_Mutation	p.P1524L	1
LTN1	STAD	chr21	30342949	30342949	A	G	Missense_Mutation	p.I413T	1
LTN1	GBM	chr21	30324491	30324491	C	A	Missense_Mutation		1
LTN1	LGG	chr21	30343646	30343646	T	C	Missense_Mutation	p.I311V	1
LTN1	LIHC	chr21	30329699	30329699	C	T	Silent	p.P949P	1
LTN1	BLCA	chr21	30316094	30316094	T	C	Missense_Mutation		1
LTN1	CESC	chr21	30316810	30316810	G	C	Missense_Mutation		1
LTN1	HNSC	chr21	30315991	30315991	G	C	Nonsense_Mutation	p.Y1406*	1
LTN1	LGG	chr21	30358528	30358528	C	A	Nonsense_Mutation		1
LTN1	LIHC	chr21	30319818	30319818	C	-	Frame_Shift_Del	p.G1152fs	1
LTN1	LUSC	chr21	30302818	30302818	T	C	Silent	p.T1797T	1
LTN1	BLCA	chr21	30331900	30331900	C	A	Missense_Mutation	p.D871Y	1
LTN1	COAD	chr21	30331798	30331798	C	A	Nonsense_Mutation	p.E905X	1
LTN1	PAAD	chr21	30341881	30341881	C	A	Silent		1
LTN1	SKCM	chr21	30343025	30343025	G	A	Missense_Mutation	p.P342S	1
LTN1	STAD	chr21	30357128	30357128	G	C	Missense_Mutation	p.A200G	1
LTN1	SKCM	chr21	30332977	30332977	C	T	Missense_Mutation	p.D739N	1
LTN1	STAD	chr21	30353449	30353449	C	T	Missense_Mutation	p.V268I	1
LTN1	ESCA	chr21	30357050	30357050	G	T	Missense_Mutation	p.P180H	1
LTN1	KIRC	chr21	30339184	30339184	A	T	Missense_Mutation	p.D543E	1
LTN1	UCEC	chr21	30315604	30315604	A	T	Missense_Mutation	p.D1471E	1
LTN1	LIHC	chr21	30341820	30341820	C	-	Frame_Shift_Del	p.E428fs	1
LTN1	BLCA	chr21	30325696	30325696	C	A	Missense_Mutation	p.A1074S	1
LTN1	PRAD	chr21	30359240	30359240	G	C	Missense_Mutation	p.R20G	1
LTN1	SKCM	chr21	30325549	30325549	A	C	Missense_Mutation	p.L1123V	1
LTN1	READ	chr21	30341850	30341850	G	A	Missense_Mutation	p.R463C	1
LTN1	SKCM	chr21	30338887	30338887	G	A	Silent	p.V688V	1
LTN1	SKCM	chr21	30307472	30307472	A	T	Missense_Mutation	p.S1612T	1
LTN1	STAD	chr21	30353449	30353449	C	T	Missense_Mutation	p.V314I	1
LTN1	HNSC	chr21	30339459	30339459	G	T	Missense_Mutation		1
LTN1	LGG	chr21	30325538	30325538	C	T	Splice_Site		1
LTN1	LUAD	chr21	30304976	30304976	C	A	Missense_Mutation	p.R1629L	1
LTN1	BLCA	chr21	30339069	30339069	A	G	Silent		1
LTN1	HNSC	chr21	30309016	30309016	G	A	Missense_Mutation	p.R1496W	1
LTN1	LIHC	chr21	30304912	30304912	T	A	Silent		1
LTN1	LIHC	chr21	30325609	30325609	T	-	Frame_Shift_Del	p.M1057fs	1
LTN1	LUSC	chr21	30359114	30359114	C	G	Missense_Mutation	p.D108H	1
LTN1	BLCA	chr21	30365173	30365173	C	A	Missense_Mutation	p.R31L	1
LTN1	COAD	chr21	30331911	30331911	G	A	Missense_Mutation	p.S867F	1
LTN1	SARC	chr21	30343621	30343621	G	T	Missense_Mutation		1
LTN1	SKCM	chr21	30339099	30339099	G	A	Missense_Mutation	p.P572S	1
LTN1	STAD	chr21	30316746	30316746	C	T	Missense_Mutation	p.G1360D	1
LTN1	STAD	chr21	30353596	30353596	C	T	Missense_Mutation	p.A219T	1
LTN1	KIRC	chr21	30332994	30332994	G	A	Missense_Mutation	p.T733I	1
LTN1	LIHC	chr21	30325540	30325540	T	C	Missense_Mutation		1
LTN1	UCEC	chr21	30332933	30332933	A	G	Silent	p.C799C	1
LTN1	LUAD	chr21	30303583	30303583	C	A	Missense_Mutation	p.G1711V	1
LTN1	BLCA	chr21	30330766	30330766	G	A	Missense_Mutation	p.H943Y	1
LTN1	ESCA	chr21	30342970	30342971	-	-	Frame_Shift_Ins		1
LTN1	PRAD	chr21	30354640	30354640	C	T	Silent	p.P209P	1
LTN1	SKCM	chr21	30318518	30318518	T	A	Silent	p.I1239I	1
LTN1	CESC	chr21	30329098	30329098	T	A	Missense_Mutation	p.E1022V	1
LTN1	SKCM	chr21	30339415	30339415	G	A	Silent	p.S512S	1
LTN1	SKCM	chr21	30329086	30329086	A	G	Missense_Mutation	p.I1026T	1
LTN1	STAD	chr21	30353596	30353596	C	T	Missense_Mutation	p.A265T	1
LTN1	HNSC	chr21	30359144	30359144	G	C	Missense_Mutation		1
LTN1	LGG	chr21	30354657	30354657	C	G	Missense_Mutation	p.D204H	1
LTN1	LIHC	chr21	30343736	30343736	C	A	Missense_Mutation	p.A281S	1
LTN1	LUAD	chr21	30303521	30303521	T	C	Missense_Mutation	p.K1732E	1
LTN1	BLCA	chr21	30307437	30307437	G	T	Silent		1
LTN1	HNSC	chr21	30303556	30303556	G	A	Missense_Mutation	p.S1720L	1
LTN1	LIHC	chr21	30329700	30329700	G	-	Frame_Shift_Del	p.P949fs	1
LTN1	LUSC	chr21	30354687	30354687	G	A	Silent	p.L240L	1
LTN1	BLCA	chr21	30338214	30338214	C	A	Missense_Mutation	p.W758C	1
LTN1	COAD	chr21	30341891	30341891	A	G	Missense_Mutation	p.L449S	1
LTN1	SARC	chr21	30343003	30343003	C	T	Missense_Mutation		1
LTN1	SKCM	chr21	30308905	30308905	C	A	Missense_Mutation	p.V1533F	1
LTN1	STAD	chr21	30339484	30339484	A	G	Silent	p.D489D	1
LTN1	STAD	chr21	30307435	30307435	A	G	Missense_Mutation	p.M1624T	1
LTN1	ESCA	chr21	30342970	30342971	-	A	Frame_Shift_Ins	p.S360fs	1
LTN1	KIRP	chr21	30339388	30339388	T	G	Missense_Mutation	p.K521N	1
LTN1	LIHC	chr21	30316013	30316013	A	G	Missense_Mutation		1
LTN1	UCEC	chr21	30332989	30332989	A	G	Missense_Mutation	p.W781R	1
LTN1	LUAD	chr21	30353440	30353440	C	A	Splice_Site		1
LTN1	BLCA	chr21	30339160	30339160	C	G	Missense_Mutation	p.E597D	1
LTN1	PRAD	chr21	30339290	30339290	T	G	Missense_Mutation	p.D508A	1
LTN1	SKCM	chr21	30338844	30338844	G	A	Missense_Mutation	p.P703S	1
LTN1	BLCA	chr21	30307608	30307608	T	C	Silent		1
LTN1	CESC	chr21	30357145	30357145	C	T	Missense_Mutation	p.M148I	1
LTN1	SARC	chr21	30308947	30308947	G	T	Missense_Mutation		1
LTN1	SKCM	chr21	30318520	30318520	T	C	Missense_Mutation	p.I1239V	1
LTN1	SKCM	chr21	30318606	30318606	C	T	Missense_Mutation	p.G1164D	1
LTN1	STAD	chr21	30307435	30307435	A	G	Missense_Mutation	p.M1670T	1
LTN1	LGG	chr21	30318165	30318165	C	T	Nonsense_Mutation	p.W1244*	1
LTN1	LIHC	chr21	30341859	30341860	-	A	Frame_Shift_Ins	p.LM413fs	1
LTN1	LUAD	chr21	30325585	30325585	G	A	Missense_Mutation	p.R1065C	1
LTN1	LIHC	chr21	30337040	30337040	T	-	Frame_Shift_Del	p.I784fs	1
LTN1	LUSC	chr21	30304833	30304833	G	T	Silent	p.R1723R	1
LTN1	BLCA	chr21	30338215	30338215	C	G	Missense_Mutation	p.W758S	1
LTN1	COAD	chr21	30354658	30354658	A	G	Silent	p.P249P	1
LTN1	PAAD	chr21	30338786	30338786	T	G	Missense_Mutation	p.K722T	1
LTN1	SARC	chr21	30308947	30308947	G	T	Missense_Mutation	p.L1519I	1
LTN1	SKCM	chr21	30318518	30318518	T	A	Silent	p.I1193I	1
LTN1	SKCM	chr21	30330842	30330842	C	T	Silent	p.L871L	1
LTN1	TGCT	chr21	30339120	30339120	C	A	Missense_Mutation		1
LTN1	GBM	chr21	30354691	30354691	C	T	Splice_Site	p.V239_splice	1
LTN1	KIRP	chr21	30339122	30339122	T	C	Missense_Mutation	p.E610G	1
LTN1	UCEC	chr21	30319921	30319922	-	A	Frame_Shift_Ins	p.F1163fs	1
LTN1	LUAD	chr21	30343757	30343757	C	A	Missense_Mutation	p.A274S	1
LTN1	BLCA	chr21	30338207	30338207	G	A	Missense_Mutation	p.L761F	1
LTN1	PRAD	chr21	30304866	30304866	C	A	Missense_Mutation	p.G1712W	1
LTN1	SKCM	chr21	30330851	30330851	G	A	Silent	p.I914I	1
LTN1	BLCA	chr21	30316194	30316194	G	C	Missense_Mutation		1
LTN1	CESC	chr21	30316810	30316810	G	C	Missense_Mutation	p.L1293V	1
LTN1	SARC	chr21	30304839	30304839	G	T	Missense_Mutation		1
LTN1	SKCM	chr21	30339415	30339415	G	A	Silent	p.S466S	1
LTN1	SKCM	chr21	30318607	30318607	C	T	Missense_Mutation	p.G1164S	1
LTN1	STAD	chr21	30316743	30316743	A	T	Missense_Mutation	p.I1361N	1
LTN1	HNSC	chr21	30303556	30303556	G	A	Missense_Mutation		1
LTN1	LGG	chr21	30343762	30343762	C	T	Missense_Mutation	p.R272H	1
LTN1	LUAD	chr21	30359174	30359174	G	A	Nonsense_Mutation	p.Q42*	1
LTN1	LIHC	chr21	30329699	30329699	C	T	Silent		1
LTN1	LIHC	chr21	30339378	30339378	T	-	Frame_Shift_Del	p.T479fs	1
LTN1	LUSC	chr21	30357092	30357092	G	T	Missense_Mutation	p.A212E	1
LTN1	BLCA	chr21	30365150	30365150	G	C	Missense_Mutation	p.Q39E	1
LTN1	COAD	chr21	30332952	30332952	T	A	Missense_Mutation	p.N793I	1
LTN1	PAAD	chr21	30359125	30359125	T	G	Missense_Mutation	p.D104A	1
LTN1	SARC	chr21	30316157	30316157	G	A	Missense_Mutation	p.T1351M	1
LTN1	STAD	chr21	30303519	30303519	T	-	Frame_Shift_Del	p.A1779fs	1
LTN1	SKCM	chr21	30332020	30332020	C	T	Splice_Site		1
LTN1	KIRP	chr21	30365165	30365165	G	T	Silent		1
LTN1	LIHC	chr21	30341826	30341826	C	A	Missense_Mutation		1
LTN1	UCEC	chr21	30341859	30341860	-	A	Frame_Shift_Ins	p.F459fs	1
LTN1	LUAD	chr21	30319883	30319883	T	A	Silent	p.L1130L	1
LTN1	BLCA	chr21	30329695	30329695	C	T	Missense_Mutation	p.D997N	1
LTN1	PRAD	chr21	30318243	30318243	C	A	Silent	p.L1264L	1
LTN1	SKCM	chr21	30307468	30307468	G	A	Missense_Mutation	p.S1659F	1
LTN1	BLCA	chr21	30330766	30330766	G	A	Missense_Mutation		1
LTN1	SARC	chr21	30324526	30324526	G	T	Missense_Mutation		1
LTN1	SKCM	chr21	30357190	30357190	G	A	Silent	p.I133I	1
LTN1	SKCM	chr21	30318520	30318520	T	C	Missense_Mutation	p.I1193V	1
LTN1	STAD	chr21	30316135	30316135	T	G	Silent	p.L1404L	1
LTN1	HNSC	chr21	30357237	30357237	C	T	Missense_Mutation		1
LTN1	LGG	chr21	30330708	30330708	C	A	Splice_Site	p.S916_splice	1
LTN1	LUAD	chr21	30357072	30357072	C	T	Missense_Mutation	p.A173T	1
LTN1	STAD	chr21	30324485	30324485	T	C	Missense_Mutation	p.E1160G	1
LTN1	KICH	chr21	30331996	30331996	C	T	Missense_Mutation		1
LTN1	LIHC	chr21	30331905	30331905	A	G	Missense_Mutation		1
LTN1	LIHC	chr21	30343636	30343636	G	-	Frame_Shift_Del	p.P314fs	1
LTN1	UCS	chr21	30302792	30302799	AGTGGACA	-	Frame_Shift_Del		1
LTN1	LUSC	chr21	30304965	30304965	G	T	Silent	p.R1679R	1
LTN1	BLCA	chr21	30331900	30331900	C	G	Missense_Mutation	p.D871H	1
LTN1	DLBC	chr21	30365143	30365143	G	A	Missense_Mutation	p.T41I	1
LTN1	PAAD	chr21	30339377	30339377	G	A	Missense_Mutation	p.T525I	1
LTN1	SARC	chr21	30303544	30303544	C	T	Missense_Mutation	p.G1724D	1
LTN1	SKCM	chr21	30303532	30303532	G	A	Missense_Mutation	p.S1728F	1
LTN1	PRAD	chr21	30331780	30331780	C	A	Splice_Site	p.D911Y	1
LTN1	SKCM	chr21	30316198	30316198	G	A	Silent	p.S1383S	1
LTN1	THCA	chr21	30308991	30308991	C	A	Missense_Mutation		1
LTN1	GBM	chr21	30359239	30359239	C	T	Missense_Mutation		1
LTN1	KIRP	chr21	30365148	30365148	C	A	Missense_Mutation		1
LTN1	LIHC	chr21	30343736	30343736	C	A	Missense_Mutation	p.A327S	1
LTN1	UCEC	chr21	30330863	30330864	-	A	Splice_Site	p.D911_splice	1
LTN1	LUAD	chr21	30329087	30329087	T	A	Missense_Mutation	p.I1026L	1
LTN1	BLCA	chr21	30365173	30365173	C	A	Missense_Mutation		1
LTN1	BLCA	chr21	30339384	30339384	C	T	Missense_Mutation	p.E523K	1
LTN1	LUAD	chr21	30342995	30342995	C	A	Missense_Mutation	p.G352C	1
LTN1	BLCA	chr21	30339160	30339160	C	G	Missense_Mutation		1
LTN1	SARC	chr21	30329255	30329255	G	T	Missense_Mutation		1
LTN1	SKCM	chr21	30357224	30357224	C	T	Missense_Mutation	p.R122Q	1
LTN1	SKCM	chr21	30338887	30338887	G	A	Silent	p.V642V	1
LTN1	HNSC	chr21	30309016	30309016	G	A	Missense_Mutation		1
LTN1	LGG	chr21	30338725	30338725	C	T	Missense_Mutation		1
LTN1	SKCM	chr21	30330851	30330851	G	A	Silent	p.I868I	1
LTN1	STAD	chr21	30339377	30339378	-	T	Frame_Shift_Ins	p.T525fs	1
LTN1	KICH	chr21	30307615	30307615	G	A	Missense_Mutation		1
LTN1	LIHC	chr21	30357196	30357196	T	C	Silent		1
LTN1	LIHC	chr21	30325557	30325557	A	-	Frame_Shift_Del	p.L1074fs	1
LTN1	UCS	chr21	30302792	30302799	AGTGGACA	-	Frame_Shift_Del	p.1804_1806del	1
LTN1	OV	chr21	30324516	30324516	C	T	Missense_Mutation	p.D1150N	1
LTN1	BLCA	chr21	30329183	30329183	G	C	Missense_Mutation	p.L1040V	1
LTN1	ESCA	chr21	30338185	30338185	A	G	Splice_Site	e11+2	1
LTN1	PAAD	chr21	30338786	30338786	T	G	Missense_Mutation	p.K676T	1
LTN1	SARC	chr21	30358501	30358501	C	A	Missense_Mutation	p.V102F	1

Copy number variation (CNV) of LTN1
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Fusion gene breakpoints (product of the structural variants (SVs)) across LTN1
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
93498	N/A	AV683764	APOC4-APOC2	chr19	45452652	+	LTN1	chr21	30360786	+
50318	BRCA	TCGA-B6-A0IJ-01A	LTN1	chr21	30365085	-	RWDD2B	chr21	30380942	-
93524	N/A	BQ125043	TPT1	chr13	45911319	-	LTN1	chr21	30320158	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source