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Translation Factor: STK39 (NCBI Gene ID:27347) |
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Gene Summary |
Gene Information | Gene Name: STK39 | Gene ID: 27347 | Gene Symbol | STK39 | Gene ID | 27347 |
Gene Name | serine/threonine kinase 39 | |
Synonyms | DCHT|PASK|SPAK | |
Cytomap | 2q24.3 | |
Type of Gene | protein-coding | |
Description | STE20/SPS1-related proline-alanine-rich protein kinaseSTE20/SPS1 homologSte20-like protein kinaseproline-alanine-rich STE20-related kinaseserine threonine kinase 39 (STE20/SPS1 homolog, yeast)serine/threonine-protein kinase 39small intestine SPAK-li | |
Modification date | 20200313 | |
UniProtAcc | . |
Child GO biological process term(s) under GO:0006412 |
GO ID | GO term |
Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STK39 | GO:0018105 | peptidyl-serine phosphorylation | 24393035 |
Hgene | STK39 | GO:0018107 | peptidyl-threonine phosphorylation | 24393035 |
Hgene | STK39 | GO:0023014 | signal transduction by protein phosphorylation | 24393035 |
Hgene | STK39 | GO:0035556 | intracellular signal transduction | 24393035 |
Hgene | STK39 | GO:1901017 | negative regulation of potassium ion transmembrane transporter activity | 24393035 |
Hgene | STK39 | GO:1901380 | negative regulation of potassium ion transmembrane transport | 24393035 |
Hgene | STK39 | GO:1905408 | negative regulation of creatine transmembrane transporter activity | 25531585 |
Hgene | STK39 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 25531585 |
Inferred gene age of translation factor. |
Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
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We searched PubMed using 'STK39[title] AND translation [title] AND human.' |
Gene | Title | PMID |
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Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
Exon skipping position in the amino acid sequence. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
Potentially (partially) lost protein functional features of UniProt. |
UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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Gene expression level across TCGA pancancer |
Gene expression level across GTEx pantissue |
Expression level of gene isoforms across TCGA pancancer |
Expression level of gene isoforms across GTEx pantissue |
Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
Cancer type | Translation factor | FC | adj.pval |
UCEC | STK39 | -1.57163095505579 | 0.03125 |
LUSC | STK39 | -2.74621891828241 | 1.48476574325348e-06 |
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Translation factor expression regulation through miRNA binding |
Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
Translation factor expression regulation through methylation in the promoter of Translation factor |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through copy number variation of Translation factor |
Cancer type | Gene | Coefficient | Pvalue |
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Strongly correlated genes belong to cellular important gene groups with STK39 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
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Protein 3D structure Visit iCn3D. |
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Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
* Edge colors based on TCGA cancer types. |
* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
PPI interactors with STK39 |
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Clinically associated variants from ClinVar. |
Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
SNVs and Indels |
Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
Copy number variation (CNV) of STK39 * Click on the image to open the original image in a new window. |
Fusion gene breakpoints (product of the structural variants (SVs)) across STK39 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion genes with this translation factor from FusionGDB2.0. |
FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
85404 | SKCM | TCGA-Z2-AA3S-06A | ALK | chr2 | 29940444 | - | STK39 | chr2 | 169038600 | - |
85404 | STAD | TCGA-BR-A4CR-01A | BAZ2B | chr2 | 160412334 | - | STK39 | chr2 | 168931741 | - |
85404 | SARC | TCGA-DX-A48L-01A | C17orf49 | chr17 | 6918475 | + | STK39 | chr2 | 169018352 | - |
85404 | Non-Cancer | 231N | CALM2 | chr2 | 47403579 | - | STK39 | chr2 | 168931741 | - |
85404 | PAAD | TCGA-IB-A7M4-01A | CERS6 | chr2 | 169313128 | - | STK39 | chr2 | 169038600 | - |
85404 | N/A | BQ330916 | COL6A3 | chr2 | 238266015 | + | STK39 | chr2 | 169068985 | + |
85404 | STAD | TCGA-BR-8078 | CUL3 | chr2 | 225400244 | - | STK39 | chr2 | 168986268 | - |
85404 | PRAD | TCGA-EJ-7782-01A | IL1RAPL2 | chrX | 104478688 | + | STK39 | chr2 | 168821236 | - |
85404 | ESCA | TCGA-IG-A3YB | KIF5C | chr2 | 149633312 | + | STK39 | chr2 | 169038600 | - |
85404 | ESCA | TCGA-2H-A9GH | LGALS3 | chr14 | 55596018 | + | STK39 | chr2 | 168997268 | - |
85404 | N/A | BM194499 | PARPBP | chr12 | 102547674 | + | STK39 | chr2 | 169024315 | - |
85404 | LGG | TCGA-TQ-A7RM-01A | RPN2 | chr20 | 35858462 | + | STK39 | chr2 | 169023917 | - |
85404 | STAD | TCGA-BR-A4IY-01A | SETD5 | chr3 | 9439661 | + | STK39 | chr2 | 169038600 | - |
85406 | LUSC | TCGA-34-5236-01A | SP3 | chr2 | 174777798 | - | STK39 | chr2 | 169038600 | - |
87566 | KIRP | TCGA-AL-3466-01A | STK39 | chr2 | 168986051 | - | CCDC150 | chr2 | 197583227 | + |
87566 | PRAD | TCGA-YJ-A8SW-01A | STK39 | chr2 | 169004771 | - | IGFBP5 | chr2 | 217559161 | + |
100983 | BRCA | TCGA-E2-A14Z-01A | STK39 | chr2 | 168921829 | - | ITGB6 | chr2 | 160994710 | - |
87566 | BRCA | TCGA-AN-A0AJ-01A | STK39 | chr2 | 168931492 | - | MAT1A | chr10 | 82045345 | - |
89414 | HNSC | TCGA-CN-A49A-01A | STK39 | chr2 | 168869144 | - | NCKAP5 | chr2 | 133489624 | - |
103221 | N/A | AA876316 | STK39 | chr2 | 169078843 | + | NFIC | chr19 | 3464961 | + |
99849 | COAD | TCGA-A6-2677 | STK39 | chr2 | 169018296 | - | OXSR1 | chr3 | 38232221 | + |
100583 | HNSC | TCGA-QK-A6IG-01A | STK39 | chr2 | 169103738 | - | PARVA | chr11 | 12495292 | + |
94941 | LUAD | TCGA-55-6968-01A | STK39 | chr2 | 168986051 | - | SCN3A | chr2 | 166012413 | - |
89420 | MESO | TCGA-UT-A88D-01B | STK39 | chr2 | 168869144 | - | SCN7A | chr2 | 167334220 | - |
87566 | N/A | AX192963 | STK39 | chr2 | 168810720 | - | TMEM106C | chr12 | 48361004 | + |
99179 | LGG | TCGA-TQ-A7RM-01A | STK39 | chr2 | 168931492 | - | TMEM245 | chr9 | 111870850 | - |
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Kaplan-Meier plots with logrank tests of overall survival (OS) |
Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
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Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
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Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Diseases associated with this translation factor. (DisGeNet 4.0) |
Disease ID | Disease Name | # PubMeds | Disease source |