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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: ANG (NCBI Gene ID:283)

Gene Summary

Gene Summary

Gene Information	Gene Name: ANG
	Gene ID: 283
	Gene Symbol	ANG
	Gene ID	283
	Gene Name	angiogenin
	Synonyms	ALS9\|HEL168\|RAA1\|RNASE4\|RNASE5
	Cytomap	14q11.2
	Type of Gene	protein-coding
	Description	angiogeninRNase 5angiogenin, ribonuclease, RNase A family, 5epididymis luminal protein 168ribonuclease 5ribonuclease A A1ribonuclease A family member 5
	Modification date	20200329
	UniProtAcc	P03950

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ANG	GO:0001525	angiogenesis	8448182
Hgene	ANG	GO:0001666	response to hypoxia	10999833\|15979542\|16490744
Hgene	ANG	GO:0001938	positive regulation of endothelial cell proliferation	9122172\|9707554
Hgene	ANG	GO:0006651	diacylglycerol biosynthetic process	2457905
Hgene	ANG	GO:0009725	response to hormone	10999833
Hgene	ANG	GO:0042327	positive regulation of phosphorylation	17125737
Hgene	ANG	GO:0048662	negative regulation of smooth muscle cell proliferation	10103013
Hgene	ANG	GO:0050714	positive regulation of protein secretion	2646638

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
ANG	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'ANG[title] AND translation [title] AND human.'

Gene	Title	PMID
ANG	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	ANG	-2.50353184068758	0.00390625
HNSC	ANG	1.7212196726537	3.1722186577099e-05
KIRC	ANG	3.59340921179483	3.33619925451438e-10
BRCA	ANG	-1.7552708676464	4.06262860503374e-14
LUAD	ANG	-1.58875698458527	8.82573688437925e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
UCS	ANG	2	1	0.0332395458596532	0.240318115942029	0.189724242424242	0.295977192828257	0.778729761998455

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCS	ANG	-0.034801243	0.009891345

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with ANG (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	ANG	DBH	0.800659859	4.05E-11
CHOL	Cell metabolism gene	ANG	GSTA1	0.801102125	3.88E-11
CHOL	Cell metabolism gene	ANG	ADH4	0.801383392	3.77E-11
CHOL	Cell metabolism gene	ANG	CBR1	0.801955349	3.57E-11
CHOL	Cell metabolism gene	ANG	AK3	0.802271818	3.46E-11
CHOL	Cell metabolism gene	ANG	SUOX	0.80360062	3.03E-11
CHOL	Cell metabolism gene	ANG	LDHD	0.803687167	3.01E-11
CHOL	Cell metabolism gene	ANG	CDA	0.804239201	2.85E-11
CHOL	Cell metabolism gene	ANG	LPA	0.804361751	2.81E-11
CHOL	Cell metabolism gene	ANG	ACOX2	0.805348936	2.55E-11
CHOL	Cell metabolism gene	ANG	GATM	0.805549589	2.50E-11
CHOL	Cell metabolism gene	ANG	DIO1	0.80607633	2.37E-11
CHOL	Cell metabolism gene	ANG	MCEE	0.806855382	2.19E-11
CHOL	Cell metabolism gene	ANG	ACAT1	0.806924678	2.18E-11
CHOL	Cell metabolism gene	ANG	GNMT	0.807044454	2.15E-11
CHOL	Cell metabolism gene	ANG	PRODH2	0.807099441	2.14E-11
CHOL	Cell metabolism gene	ANG	INHBC	0.807277223	2.10E-11
CHOL	Cell metabolism gene	ANG	MLYCD	0.807803429	1.99E-11
CHOL	Cell metabolism gene	ANG	NAT2	0.807944984	1.97E-11
CHOL	Cell metabolism gene	ANG	CA14	0.80829176	1.90E-11
CHOL	Cell metabolism gene	ANG	MPST	0.808552209	1.85E-11
CHOL	Cell metabolism gene	ANG	A2M	0.809303582	1.71E-11
CHOL	Cell metabolism gene	ANG	APOC3	0.809461217	1.68E-11
CHOL	Cell metabolism gene	ANG	FABP1	0.810257887	1.55E-11
CHOL	Cell metabolism gene	ANG	ABAT	0.810331899	1.54E-11
CHOL	Cell metabolism gene	ANG	GSTA2	0.810545629	1.51E-11
CHOL	Cell metabolism gene	ANG	PPP2R1B	0.811891774	1.31E-11
CHOL	Cell metabolism gene	ANG	GBA3	0.812361312	1.25E-11
CHOL	Cell metabolism gene	ANG	PLIN1	0.812871268	1.19E-11
CHOL	Cell metabolism gene	ANG	KMO	0.812994796	1.17E-11
CHOL	Cell metabolism gene	ANG	PCK1	0.813177034	1.15E-11
CHOL	Cell metabolism gene	ANG	PLA2G12B	0.813487091	1.11E-11
CHOL	Cell metabolism gene	ANG	PANK1	0.813730343	1.08E-11
CHOL	Cell metabolism gene	ANG	UGT2B7	0.814263035	1.02E-11
CHOL	Cell metabolism gene	ANG	ADH7	0.814273245	1.02E-11
CHOL	Cell metabolism gene	ANG	APOA5	0.814516621	9.98E-12
CHOL	Cell metabolism gene	ANG	AGXT	0.814891643	9.59E-12
CHOL	Cell metabolism gene	ANG	UGT2A1	0.814937193	9.54E-12
CHOL	Cell metabolism gene	ANG	HSD17B10	0.815166557	9.31E-12
CHOL	Cell metabolism gene	ANG	ETNK2	0.817131269	7.56E-12
CHOL	Cell metabolism gene	ANG	UGT1A1	0.817680425	7.13E-12
CHOL	Cell metabolism gene	ANG	GSTO1	0.818898777	6.25E-12
CHOL	Cell metabolism gene	ANG	CES2	0.818919994	6.24E-12
CHOL	Cell metabolism gene	ANG	TST	0.81947268	5.88E-12
CHOL	Cell metabolism gene	ANG	DAK	0.819507381	5.85E-12
CHOL	Cell metabolism gene	ANG	NEU4	0.821146539	4.90E-12
CHOL	Cell metabolism gene	ANG	AGL	0.823074522	3.96E-12
CHOL	Cell metabolism gene	ANG	MUT	0.823651861	3.71E-12
CHOL	Cell metabolism gene	ANG	HIBADH	0.824580283	3.35E-12
CHOL	Cell metabolism gene	ANG	SULT2A1	0.824788969	3.27E-12
CHOL	Cell metabolism gene	ANG	EPHX1	0.825011776	3.19E-12
CHOL	Cell metabolism gene	ANG	DHRS4	0.826651009	2.65E-12
CHOL	Cell metabolism gene	ANG	HADH	0.827567584	2.39E-12
CHOL	Cell metabolism gene	ANG	TDO2	0.827885351	2.30E-12
CHOL	Cell metabolism gene	ANG	OTC	0.828972546	2.03E-12
CHOL	Cell metabolism gene	ANG	GCAT	0.829051042	2.02E-12
CHOL	Cell metabolism gene	ANG	GPT	0.830123722	1.78E-12
CHOL	Cell metabolism gene	ANG	IVD	0.830768337	1.65E-12
CHOL	Cell metabolism gene	ANG	BHMT	0.831116491	1.59E-12
CHOL	Cell metabolism gene	ANG	DPYS	0.831312713	1.55E-12
CHOL	Cell metabolism gene	ANG	ALDH2	0.831742712	1.47E-12
CHOL	Cell metabolism gene	ANG	SLC25A10	0.833426162	1.21E-12
CHOL	Cell metabolism gene	ANG	F9	0.833941381	1.14E-12
CHOL	Cell metabolism gene	ANG	ABCB11	0.83457117	1.05E-12
CHOL	Cell metabolism gene	ANG	DAO	0.834868456	1.02E-12
CHOL	Cell metabolism gene	ANG	SLC10A1	0.834954871	1.01E-12
CHOL	Cell metabolism gene	ANG	UGT1A4	0.835232475	9.75E-13
CHOL	Cell metabolism gene	ANG	GCGR	0.836871165	8.00E-13
CHOL	Cell metabolism gene	ANG	AGXT2	0.83702017	7.86E-13
CHOL	Cell metabolism gene	ANG	PHYH	0.837100232	7.78E-13
CHOL	Cell metabolism gene	ANG	GLS2	0.837107552	7.77E-13
CHOL	Cell metabolism gene	ANG	ABCG5	0.837431117	7.47E-13
CHOL	Cell metabolism gene	ANG	ALDH5A1	0.837453523	7.45E-13
CHOL	Cell metabolism gene	ANG	PLIN2	0.837717162	7.22E-13
CHOL	Cell metabolism gene	ANG	G6PC	0.837909356	7.05E-13
CHOL	Cell metabolism gene	ANG	ARG1	0.838342297	6.69E-13
CHOL	Cell metabolism gene	ANG	SLC25A20	0.839022427	6.15E-13
CHOL	Cell metabolism gene	ANG	FAH	0.839254027	5.98E-13
CHOL	Cell metabolism gene	ANG	CPS1	0.840020433	5.44E-13
CHOL	Cell metabolism gene	ANG	PNPO	0.840688859	5.01E-13
CHOL	Cell metabolism gene	ANG	NDST3	0.840998606	4.82E-13
CHOL	Cell metabolism gene	ANG	UPB1	0.841030717	4.80E-13
CHOL	Cell metabolism gene	ANG	SDHB	0.841827872	4.34E-13
CHOL	Cell metabolism gene	ANG	ALDH7A1	0.842165275	4.16E-13
CHOL	Cell metabolism gene	ANG	SLC25A15	0.842794459	3.85E-13
CHOL	Cell metabolism gene	ANG	GPD1	0.843003952	3.74E-13
CHOL	Cell metabolism gene	ANG	MLXIPL	0.844901143	2.94E-13
CHOL	Cell metabolism gene	ANG	MTHFD1	0.845300404	2.79E-13
CHOL	Cell metabolism gene	ANG	FMO3	0.845516801	2.72E-13
CHOL	Cell metabolism gene	ANG	AKR1C4	0.845657728	2.67E-13
CHOL	Cell metabolism gene	ANG	PROZ	0.845843567	2.61E-13
CHOL	Cell metabolism gene	ANG	EHHADH	0.84616604	2.50E-13
CHOL	Cell metabolism gene	ANG	APOC2	0.849574642	1.60E-13
CHOL	Cell metabolism gene	ANG	ABCB4	0.850758723	1.37E-13
CHOL	Cell metabolism gene	ANG	SDS	0.850945971	1.33E-13
CHOL	Cell metabolism gene	ANG	HAAO	0.851613614	1.22E-13
CHOL	Cell metabolism gene	ANG	HAO1	0.853032189	1.01E-13
CHOL	Cell metabolism gene	ANG	GOT2	0.853503605	9.44E-14
CHOL	Cell metabolism gene	ANG	GCDH	0.853768512	9.11E-14
CHOL	Cell metabolism gene	ANG	HSD17B4	0.853971109	8.86E-14
CHOL	Cell metabolism gene	ANG	PIPOX	0.854261	8.51E-14
CHOL	Cell metabolism gene	ANG	FBP1	0.854381261	8.37E-14
CHOL	Cell metabolism gene	ANG	HAO2	0.855249038	7.43E-14
CHOL	Cell metabolism gene	ANG	ABCG2	0.856874588	5.93E-14
CHOL	Cell metabolism gene	ANG	MTTP	0.857685949	5.29E-14
CHOL	Cell metabolism gene	ANG	ACSL1	0.85777198	5.23E-14
CHOL	Cell metabolism gene	ANG	TAT	0.85842334	4.77E-14
CHOL	Cell metabolism gene	ANG	BDH1	0.859155559	4.30E-14
CHOL	Cell metabolism gene	ANG	ACADS	0.860358127	3.62E-14
CHOL	Cell metabolism gene	ANG	UGT2B10	0.860389813	3.60E-14
CHOL	Cell metabolism gene	ANG	CTH	0.862141148	2.80E-14
CHOL	Cell metabolism gene	ANG	SLC25A13	0.86364919	2.24E-14
CHOL	Cell metabolism gene	ANG	ACADSB	0.865144756	1.80E-14
CHOL	Cell metabolism gene	ANG	AFMID	0.865665196	1.66E-14
CHOL	Cell metabolism gene	ANG	DHODH	0.865681166	1.66E-14
CHOL	Cell metabolism gene	ANG	TM7SF2	0.866132679	1.55E-14
CHOL	Cell metabolism gene	ANG	SLC2A2	0.869347646	9.51E-15
CHOL	Cell metabolism gene	ANG	ACSM5	0.87042057	8.06E-15
CHOL	Cell metabolism gene	ANG	ACAA2	0.872571654	5.75E-15
CHOL	Cell metabolism gene	ANG	ALDOB	0.872997628	5.37E-15
CHOL	Cell metabolism gene	ANG	GRHPR	0.873434201	5.01E-15
CHOL	Cell metabolism gene	ANG	CDO1	0.873706197	4.80E-15
CHOL	Cell metabolism gene	ANG	APOE	0.874093385	4.51E-15
CHOL	Cell metabolism gene	ANG	CBS	0.87463417	4.14E-15
CHOL	Cell metabolism gene	ANG	SRD5A2	0.874649949	4.12E-15
CHOL	Cell metabolism gene	ANG	ASL	0.874808801	4.02E-15
CHOL	Cell metabolism gene	ANG	CAT	0.874963575	3.92E-15
CHOL	Cell metabolism gene	ANG	AKR1D1	0.875376625	3.67E-15
CHOL	Cell metabolism gene	ANG	CA5A	0.875944454	3.34E-15
CHOL	Cell metabolism gene	ANG	PCK2	0.876681801	2.96E-15
CHOL	Cell metabolism gene	ANG	SORD	0.877180157	2.73E-15
CHOL	Cell metabolism gene	ANG	ACY1	0.877574655	2.56E-15
CHOL	Cell metabolism gene	ANG	GPT2	0.878246123	2.29E-15
CHOL	Cell metabolism gene	ANG	ACAA1	0.878464914	2.21E-15
CHOL	Cell metabolism gene	ANG	ADI1	0.878498412	2.20E-15
CHOL	Cell metabolism gene	ANG	LCAT	0.879448104	1.87E-15
CHOL	Cell metabolism gene	ANG	GLYCTK	0.879825111	1.76E-15
CHOL	Cell metabolism gene	ANG	DHRS3	0.880625074	1.54E-15
CHOL	Cell metabolism gene	ANG	SCP2	0.881009917	1.44E-15
CHOL	Cell metabolism gene	ANG	DNMT3L	0.882200777	1.17E-15
CHOL	Cell metabolism gene	ANG	SUCLG2	0.883085502	1.01E-15
CHOL	Cell metabolism gene	ANG	SLC22A1	0.884340074	8.09E-16
CHOL	Cell metabolism gene	ANG	EBP	0.885106378	7.07E-16
CHOL	Cell metabolism gene	ANG	RDH16	0.885443975	6.66E-16
CHOL	Cell metabolism gene	ANG	UROC1	0.887511588	4.60E-16
CHOL	Cell metabolism gene	ANG	ENPP7	0.887912194	4.27E-16
CHOL	Cell metabolism gene	ANG	PFKFB1	0.88895288	3.54E-16
CHOL	Cell metabolism gene	ANG	GYS2	0.890540326	2.64E-16
CHOL	Cell metabolism gene	ANG	ECHS1	0.890624404	2.60E-16
CHOL	Cell metabolism gene	ANG	CNDP1	0.892838106	1.71E-16
CHOL	Cell metabolism gene	ANG	ACOT12	0.893083117	1.63E-16
CHOL	Cell metabolism gene	ANG	PEMT	0.894654834	1.21E-16
CHOL	Cell metabolism gene	ANG	ALAS1	0.896781343	7.96E-17
CHOL	Cell metabolism gene	ANG	SLC27A5	0.899576196	4.54E-17
CHOL	Cell metabolism gene	ANG	HMGCL	0.910669253	4.11E-18
CHOL	Cell metabolism gene	ANG	ACOX1	0.913367837	2.18E-18
CHOL	Cell metabolism gene	ANG	QDPR	0.914571129	1.64E-18
CHOL	Cell metabolism gene	ANG	GLUD1	0.920578413	3.63E-19
CHOL	Cell metabolism gene	ANG	KHK	0.9271007	6.14E-20
CHOL	Cell metabolism gene	ANG	HAGH	0.93092306	2.00E-20
CHOL	CGC	ANG	ESR1	0.809612765	1.66E-11
CHOL	CGC	ANG	MGMT	0.81461026	9.88E-12
CHOL	CGC	ANG	ALDH2	0.831742712	1.47E-12
CHOL	CGC	ANG	SDHB	0.841827872	4.34E-13
CHOL	Epifactor	ANG	GADD45G	0.808812363	1.80E-11
CHOL	Epifactor	ANG	ZGPAT	0.81158817	1.35E-11
CHOL	Epifactor	ANG	CECR2	0.837075119	7.80E-13
CHOL	Epifactor	ANG	MST1	0.876253039	3.18E-15
CHOL	Epifactor	ANG	DNMT3L	0.882200777	1.17E-15
CHOL	IUPHAR	ANG	SLC26A1	0.800508779	4.11E-11
CHOL	IUPHAR	ANG	DBH	0.800659859	4.05E-11
CHOL	IUPHAR	ANG	KCNJ8	0.801029767	3.90E-11
CHOL	IUPHAR	ANG	SLC25A42	0.801549426	3.71E-11
CHOL	IUPHAR	ANG	CBR1	0.801955349	3.57E-11
CHOL	IUPHAR	ANG	SLC16A2	0.802238066	3.47E-11
CHOL	IUPHAR	ANG	FXYD1	0.80233926	3.43E-11
CHOL	IUPHAR	ANG	FCGRT	0.80257688	3.36E-11
CHOL	IUPHAR	ANG	SLC13A5	0.803185579	3.16E-11
CHOL	IUPHAR	ANG	CDA	0.804239201	2.85E-11
CHOL	IUPHAR	ANG	SLC31A1	0.804520831	2.77E-11
CHOL	IUPHAR	ANG	CYP4V2	0.80486652	2.68E-11
CHOL	IUPHAR	ANG	GATM	0.805549589	2.50E-11
CHOL	IUPHAR	ANG	DIO1	0.80607633	2.37E-11
CHOL	IUPHAR	ANG	CYP39A1	0.806558518	2.26E-11
CHOL	IUPHAR	ANG	ACAT1	0.806924678	2.18E-11
CHOL	IUPHAR	ANG	MLYCD	0.807803429	1.99E-11
CHOL	IUPHAR	ANG	CA14	0.80829176	1.90E-11
CHOL	IUPHAR	ANG	CYP2A13	0.808474137	1.86E-11
CHOL	IUPHAR	ANG	MPST	0.808552209	1.85E-11
CHOL	IUPHAR	ANG	CYP2E1	0.808806362	1.80E-11
CHOL	IUPHAR	ANG	ESR1	0.809612765	1.66E-11
CHOL	IUPHAR	ANG	FABP1	0.810257887	1.55E-11
CHOL	IUPHAR	ANG	ABAT	0.810331899	1.54E-11
CHOL	IUPHAR	ANG	F11	0.811558436	1.36E-11
CHOL	IUPHAR	ANG	CYP2J2	0.811970911	1.30E-11
CHOL	IUPHAR	ANG	KMO	0.812994796	1.17E-11
CHOL	IUPHAR	ANG	UGT1A1	0.817680425	7.13E-12
CHOL	IUPHAR	ANG	RBP5	0.818354175	6.63E-12
CHOL	IUPHAR	ANG	GSTO1	0.818898777	6.25E-12
CHOL	IUPHAR	ANG	NR1I2	0.821845625	4.53E-12
CHOL	IUPHAR	ANG	SLC22A7	0.822954022	4.01E-12
CHOL	IUPHAR	ANG	CYP4F2	0.823785752	3.66E-12
CHOL	IUPHAR	ANG	CYP4A11	0.824988024	3.20E-12
CHOL	IUPHAR	ANG	IL17RC	0.826666236	2.65E-12
CHOL	IUPHAR	ANG	TDO2	0.827885351	2.30E-12
CHOL	IUPHAR	ANG	CYP1A2	0.828458986	2.16E-12
CHOL	IUPHAR	ANG	SFXN1	0.83121226	1.57E-12
CHOL	IUPHAR	ANG	ALDH2	0.831742712	1.47E-12
CHOL	IUPHAR	ANG	SLC25A10	0.833426162	1.21E-12
CHOL	IUPHAR	ANG	SERPINC1	0.83353906	1.19E-12
CHOL	IUPHAR	ANG	F9	0.833941381	1.14E-12
CHOL	IUPHAR	ANG	AQP11	0.834043321	1.12E-12
CHOL	IUPHAR	ANG	ABCB11	0.83457117	1.05E-12
CHOL	IUPHAR	ANG	SLC10A1	0.834954871	1.01E-12
CHOL	IUPHAR	ANG	CYP4F12	0.835997822	8.89E-13
CHOL	IUPHAR	ANG	SLC34A1	0.836701945	8.17E-13
CHOL	IUPHAR	ANG	GCGR	0.836871165	8.00E-13
CHOL	IUPHAR	ANG	CECR2	0.837075119	7.80E-13
CHOL	IUPHAR	ANG	ABCG5	0.837431117	7.47E-13
CHOL	IUPHAR	ANG	ALDH5A1	0.837453523	7.45E-13
CHOL	IUPHAR	ANG	ARG1	0.838342297	6.69E-13
CHOL	IUPHAR	ANG	SLC25A20	0.839022427	6.15E-13
CHOL	IUPHAR	ANG	SLC16A13	0.840160867	5.35E-13
CHOL	IUPHAR	ANG	CPN2	0.840969588	4.83E-13
CHOL	IUPHAR	ANG	CYP8B1	0.841405843	4.58E-13
CHOL	IUPHAR	ANG	CYP2A6	0.841617783	4.46E-13
CHOL	IUPHAR	ANG	SLC6A12	0.842690434	3.90E-13
CHOL	IUPHAR	ANG	SLC25A15	0.842794459	3.85E-13
CHOL	IUPHAR	ANG	CYP2C9	0.843576686	3.48E-13
CHOL	IUPHAR	ANG	FOLH1B	0.845747081	2.64E-13
CHOL	IUPHAR	ANG	CYP27A1	0.846661994	2.34E-13
CHOL	IUPHAR	ANG	CYP3A4	0.849319507	1.66E-13
CHOL	IUPHAR	ANG	ABCB4	0.850758723	1.37E-13
CHOL	IUPHAR	ANG	ASPG	0.854546609	8.19E-14
CHOL	IUPHAR	ANG	CYP1A1	0.85527774	7.40E-14
CHOL	IUPHAR	ANG	SLC25A18	0.856575846	6.18E-14
CHOL	IUPHAR	ANG	ABCG2	0.856874588	5.93E-14
CHOL	IUPHAR	ANG	AQP9	0.857642081	5.33E-14
CHOL	IUPHAR	ANG	CYP7A1	0.85835112	4.82E-14
CHOL	IUPHAR	ANG	TAT	0.85842334	4.77E-14
CHOL	IUPHAR	ANG	CD14	0.860919834	3.34E-14
CHOL	IUPHAR	ANG	TTR	0.862121339	2.81E-14
CHOL	IUPHAR	ANG	CTH	0.862141148	2.80E-14
CHOL	IUPHAR	ANG	SLC38A4	0.862290904	2.74E-14
CHOL	IUPHAR	ANG	F12	0.862766295	2.55E-14
CHOL	IUPHAR	ANG	SLC25A13	0.86364919	2.24E-14
CHOL	IUPHAR	ANG	DHODH	0.865681166	1.66E-14
CHOL	IUPHAR	ANG	KLKB1	0.867629333	1.24E-14
CHOL	IUPHAR	ANG	CYP2A7	0.867847909	1.20E-14
CHOL	IUPHAR	ANG	CHRNA4	0.867980311	1.17E-14
CHOL	IUPHAR	ANG	CYP2D6	0.868455287	1.09E-14
CHOL	IUPHAR	ANG	SLC2A2	0.869347646	9.51E-15
CHOL	IUPHAR	ANG	ADRA1A	0.871538363	6.77E-15
CHOL	IUPHAR	ANG	NR1I3	0.871979059	6.31E-15
CHOL	IUPHAR	ANG	CBS	0.87463417	4.14E-15
CHOL	IUPHAR	ANG	SRD5A2	0.874649949	4.12E-15
CHOL	IUPHAR	ANG	CAT	0.874963575	3.92E-15
CHOL	IUPHAR	ANG	CA5A	0.875944454	3.34E-15
CHOL	IUPHAR	ANG	SLC6A13	0.882304048	1.15E-15
CHOL	IUPHAR	ANG	MOGAT2	0.883247426	9.79E-16
CHOL	IUPHAR	ANG	SLC22A1	0.884340074	8.09E-16
CHOL	IUPHAR	ANG	SLC22A25	0.887268291	4.80E-16
CHOL	IUPHAR	ANG	CYP4A22	0.891481018	2.21E-16
CHOL	IUPHAR	ANG	CNDP1	0.892838106	1.71E-16
CHOL	IUPHAR	ANG	CYP3A43	0.898584364	5.55E-17
CHOL	IUPHAR	ANG	SLC27A5	0.899576196	4.54E-17
CHOL	IUPHAR	ANG	SLC47A1	0.902649051	2.40E-17
CHOL	IUPHAR	ANG	SLC22A10	0.905527597	1.30E-17
CHOL	TF	ANG	TBX15	0.805960036	2.40E-11
CHOL	TF	ANG	ESR1	0.809612765	1.66E-11
CHOL	TF	ANG	ZGPAT	0.81158817	1.35E-11
CHOL	TF	ANG	NR1I2	0.821845625	4.53E-12
CHOL	TF	ANG	MLXIPL	0.844901143	2.94E-13
CHOL	TF	ANG	ARID3C	0.869699326	9.01E-15
CHOL	TF	ANG	NR1I3	0.871979059	6.31E-15
CHOL	TF	ANG	ATF5	0.890987165	2.43E-16
CHOL	TSG	ANG	GNMT	0.807044454	2.15E-11
CHOL	TSG	ANG	GADD45G	0.808812363	1.80E-11
CHOL	TSG	ANG	ESR1	0.809612765	1.66E-11
CHOL	TSG	ANG	IQGAP2	0.811498269	1.37E-11
CHOL	TSG	ANG	PPP2R1B	0.811891774	1.31E-11
CHOL	TSG	ANG	BMP10	0.812077934	1.29E-11
CHOL	TSG	ANG	OSGIN1	0.815967844	8.56E-12
CHOL	TSG	ANG	MT2A	0.820745651	5.12E-12
CHOL	TSG	ANG	MT1G	0.820833002	5.07E-12
CHOL	TSG	ANG	ST7	0.821393566	4.76E-12
CHOL	TSG	ANG	NR1I2	0.821845625	4.53E-12
CHOL	TSG	ANG	GLS2	0.837107552	7.77E-13
CHOL	TSG	ANG	ARG1	0.838342297	6.69E-13
CHOL	TSG	ANG	MT1F	0.839218429	6.01E-13
CHOL	TSG	ANG	SDHB	0.841827872	4.34E-13
CHOL	TSG	ANG	HEPACAM	0.843890569	3.35E-13
CHOL	TSG	ANG	PEBP1	0.848427623	1.86E-13
CHOL	TSG	ANG	FBP1	0.854381261	8.37E-14
CHOL	TSG	ANG	ABCG2	0.856874588	5.93E-14
CHOL	TSG	ANG	TAT	0.85842334	4.77E-14
CHOL	TSG	ANG	CDO1	0.873706197	4.80E-15
CHOL	TSG	ANG	CAT	0.874963575	3.92E-15
CHOL	TSG	ANG	MST1	0.876253039	3.18E-15
CHOL	TSG	ANG	ACY1	0.877574655	2.56E-15
CHOL	TSG	ANG	SEC14L2	0.879959327	1.72E-15
CHOL	TSG	ANG	CYB5A	0.899904673	4.24E-17
ESCA	TF	ANG	FOXA3	0.806598825	3.56E-46
KICH	Cell metabolism gene	ANG	ENPP7	0.801646933	1.36E-21
KICH	Cell metabolism gene	ANG	PTGDS	0.802409689	1.16E-21
KICH	Cell metabolism gene	ANG	CP	0.802662884	1.11E-21
KICH	Cell metabolism gene	ANG	DAO	0.803413583	9.50E-22
KICH	Cell metabolism gene	ANG	PIPOX	0.80371384	8.94E-22
KICH	Cell metabolism gene	ANG	HAO2	0.803932295	8.55E-22
KICH	Cell metabolism gene	ANG	AKAP5	0.803932332	8.55E-22
KICH	Cell metabolism gene	ANG	UPB1	0.80596822	5.64E-22
KICH	Cell metabolism gene	ANG	NEU4	0.805997162	5.60E-22
KICH	Cell metabolism gene	ANG	NME7	0.807539987	4.07E-22
KICH	Cell metabolism gene	ANG	ETNK2	0.807958333	3.73E-22
KICH	Cell metabolism gene	ANG	HS6ST2	0.80800411	3.70E-22
KICH	Cell metabolism gene	ANG	NAT2	0.810115089	2.38E-22
KICH	Cell metabolism gene	ANG	BHMT	0.811757819	1.68E-22
KICH	Cell metabolism gene	ANG	PRODH2	0.812773894	1.35E-22
KICH	Cell metabolism gene	ANG	ARSF	0.813246348	1.22E-22
KICH	Cell metabolism gene	ANG	UGT2B10	0.813915297	1.06E-22
KICH	Cell metabolism gene	ANG	PKLR	0.817987776	4.34E-23
KICH	Cell metabolism gene	ANG	DCN	0.818252367	4.09E-23
KICH	Cell metabolism gene	ANG	DDC	0.820201948	2.65E-23
KICH	Cell metabolism gene	ANG	ENPP6	0.820240615	2.63E-23
KICH	Cell metabolism gene	ANG	TYRP1	0.825631001	7.68E-24
KICH	Cell metabolism gene	ANG	AFMID	0.825967616	7.10E-24
KICH	Cell metabolism gene	ANG	BST1	0.826381258	6.45E-24
KICH	Cell metabolism gene	ANG	DPYS	0.827601057	4.85E-24
KICH	Cell metabolism gene	ANG	ANPEP	0.828318888	4.09E-24
KICH	Cell metabolism gene	ANG	BBOX1	0.828353856	4.06E-24
KICH	Cell metabolism gene	ANG	ARSB	0.828428717	3.99E-24
KICH	Cell metabolism gene	ANG	GBA3	0.829214252	3.31E-24
KICH	Cell metabolism gene	ANG	DIO1	0.833250831	1.25E-24
KICH	Cell metabolism gene	ANG	FTCD	0.836707927	5.35E-25
KICH	Cell metabolism gene	ANG	FMOD	0.837511844	4.37E-25
KICH	Cell metabolism gene	ANG	TREH	0.83766923	4.20E-25
KICH	Cell metabolism gene	ANG	CUBN	0.838949949	3.04E-25
KICH	Cell metabolism gene	ANG	DHDH	0.839069983	2.95E-25
KICH	Cell metabolism gene	ANG	GYG2	0.839991188	2.34E-25
KICH	Cell metabolism gene	ANG	ACSM2A	0.841243037	1.70E-25
KICH	Cell metabolism gene	ANG	SLC23A1	0.841867229	1.44E-25
KICH	Cell metabolism gene	ANG	GGT1	0.842880829	1.11E-25
KICH	Cell metabolism gene	ANG	ACMSD	0.843390205	9.72E-26
KICH	Cell metabolism gene	ANG	AGXT2	0.844946	6.46E-26
KICH	Cell metabolism gene	ANG	ACY3	0.845933191	4.97E-26
KICH	Cell metabolism gene	ANG	UGT2A3	0.861461825	6.27E-28
KICH	Cell metabolism gene	ANG	ASS1	0.863694624	3.20E-28
KICH	Cell metabolism gene	ANG	PROC	0.878172911	3.01E-30
KICH	CGC	ANG	A1CF	0.810522879	2.18E-22
KICH	CGC	ANG	FGFR3	0.811551358	1.75E-22
KICH	CGC	ANG	EPHA7	0.812480493	1.44E-22
KICH	CGC	ANG	WT1	0.813445049	1.17E-22
KICH	Epifactor	ANG	A1CF	0.810522879	2.18E-22
KICH	IUPHAR	ANG	CRABP2	0.800002331	1.89E-21
KICH	IUPHAR	ANG	SLC22A12	0.800247145	1.80E-21
KICH	IUPHAR	ANG	ABCB6	0.800263079	1.79E-21
KICH	IUPHAR	ANG	ACE2	0.800456397	1.72E-21
KICH	IUPHAR	ANG	PAK3	0.800998384	1.55E-21
KICH	IUPHAR	ANG	SLC15A2	0.801256016	1.47E-21
KICH	IUPHAR	ANG	C1R	0.801414786	1.42E-21
KICH	IUPHAR	ANG	AQP2	0.802363708	1.18E-21
KICH	IUPHAR	ANG	PTGDS	0.802409689	1.16E-21
KICH	IUPHAR	ANG	SLC5A2	0.802676116	1.10E-21
KICH	IUPHAR	ANG	KCNH6	0.802680984	1.10E-21
KICH	IUPHAR	ANG	NLRP6	0.802938748	1.05E-21
KICH	IUPHAR	ANG	SLC38A5	0.80369051	8.98E-22
KICH	IUPHAR	ANG	CYP21A2	0.804757741	7.23E-22
KICH	IUPHAR	ANG	NEK11	0.811268678	1.86E-22
KICH	IUPHAR	ANG	FGFR3	0.811551358	1.75E-22
KICH	IUPHAR	ANG	SLC17A1	0.811653525	1.71E-22
KICH	IUPHAR	ANG	ADORA1	0.811779108	1.67E-22
KICH	IUPHAR	ANG	EPHA7	0.812480493	1.44E-22
KICH	IUPHAR	ANG	CPN2	0.81279297	1.34E-22
KICH	IUPHAR	ANG	SLC5A11	0.814801838	8.72E-23
KICH	IUPHAR	ANG	CYP4A11	0.815381124	7.69E-23
KICH	IUPHAR	ANG	SLC6A18	0.81737938	4.96E-23
KICH	IUPHAR	ANG	STK19	0.81790301	4.42E-23
KICH	IUPHAR	ANG	PKLR	0.817987776	4.34E-23
KICH	IUPHAR	ANG	SLC17A3	0.818637506	3.76E-23
KICH	IUPHAR	ANG	SLC13A2	0.819891841	2.84E-23
KICH	IUPHAR	ANG	DDC	0.820201948	2.65E-23
KICH	IUPHAR	ANG	KCNT2	0.821190387	2.12E-23
KICH	IUPHAR	ANG	SLC6A13	0.821471911	1.99E-23
KICH	IUPHAR	ANG	CYP2B6	0.822161455	1.70E-23
KICH	IUPHAR	ANG	MTNR1A	0.822354622	1.63E-23
KICH	IUPHAR	ANG	CPZ	0.822355419	1.63E-23
KICH	IUPHAR	ANG	MRGPRF	0.823010596	1.40E-23
KICH	IUPHAR	ANG	CHRNA4	0.826086794	6.91E-24
KICH	IUPHAR	ANG	SLC39A5	0.827421572	5.06E-24
KICH	IUPHAR	ANG	SLC47A2	0.827458708	5.01E-24
KICH	IUPHAR	ANG	ANPEP	0.828318888	4.09E-24
KICH	IUPHAR	ANG	EDAR	0.830325746	2.54E-24
KICH	IUPHAR	ANG	IL17RB	0.832316199	1.57E-24
KICH	IUPHAR	ANG	SLC7A9	0.832637339	1.46E-24
KICH	IUPHAR	ANG	DIO1	0.833250831	1.25E-24
KICH	IUPHAR	ANG	SLC22A11	0.833693082	1.13E-24
KICH	IUPHAR	ANG	SLC5A8	0.83477828	8.63E-25
KICH	IUPHAR	ANG	SLC9A3	0.835517954	7.19E-25
KICH	IUPHAR	ANG	XPNPEP2	0.835639407	6.97E-25
KICH	IUPHAR	ANG	SLC5A10	0.837578914	4.30E-25
KICH	IUPHAR	ANG	PTGER1	0.838486053	3.42E-25
KICH	IUPHAR	ANG	CYP4F12	0.839357546	2.74E-25
KICH	IUPHAR	ANG	SLC13A1	0.840630015	1.98E-25
KICH	IUPHAR	ANG	SLC23A1	0.841867229	1.44E-25
KICH	IUPHAR	ANG	DPEP1	0.843557233	9.30E-26
KICH	IUPHAR	ANG	CYP2J2	0.85255999	8.18E-27
KICH	IUPHAR	ANG	SLC28A1	0.86152586	6.15E-28
KICH	IUPHAR	ANG	SLC16A9	0.863749353	3.15E-28
KICH	IUPHAR	ANG	PROC	0.878172911	3.01E-30
KICH	IUPHAR	ANG	IL22RA1	0.879063843	2.21E-30
KICH	IUPHAR	ANG	RBP4	0.887809302	9.54E-32
KICH	Kinase	ANG	PAK3	0.800998384	1.55E-21
KICH	Kinase	ANG	NEK11	0.811268678	1.86E-22
KICH	Kinase	ANG	FGFR3	0.811551358	1.75E-22
KICH	Kinase	ANG	EPHA7	0.812480493	1.44E-22
KICH	Kinase	ANG	STK19	0.81790301	4.42E-23
KICH	Kinase	ANG	ALPK2	0.863125967	3.81E-28
KICH	TF	ANG	PKNOX2	0.805172913	6.64E-22
KICH	TF	ANG	IRX1	0.805874055	5.75E-22
KICH	TF	ANG	WT1	0.813445049	1.17E-22
KICH	TF	ANG	GLIS1	0.816055569	6.63E-23
KICH	TF	ANG	DACH2	0.81857901	3.80E-23
KICH	TF	ANG	IRX2	0.819389684	3.18E-23
KICH	TF	ANG	FOXJ1	0.82436014	1.03E-23
KICH	TF	ANG	TCF21	0.826891301	5.73E-24
KICH	TF	ANG	DZIP1	0.843876022	8.56E-26
KICH	TF	ANG	PITX2	0.857990388	1.74E-27
KICH	TSG	ANG	IRX1	0.805874055	5.75E-22
KICH	TSG	ANG	TCEAL7	0.807797252	3.86E-22
KICH	TSG	ANG	MT1M	0.809319026	2.81E-22
KICH	TSG	ANG	WT1	0.813445049	1.17E-22
KICH	TSG	ANG	CXCL14	0.813783041	1.09E-22
KICH	TSG	ANG	DCN	0.818252367	4.09E-23
KICH	TSG	ANG	BNIP3L	0.820260782	2.61E-23
KICH	TSG	ANG	CXCL12	0.820757729	2.34E-23
KICH	TSG	ANG	SLC5A8	0.83477828	8.63E-25
KICH	TSG	ANG	VIL1	0.842467076	1.24E-25
KICH	TSG	ANG	MT1G	0.843521452	9.39E-26
KICH	TSG	ANG	TRIM15	0.843561515	9.29E-26
KICH	TSG	ANG	ASS1	0.863694624	3.20E-28
KICH	TSG	ANG	MT1F	0.881910883	8.17E-31
TGCT	Cell metabolism gene	ANG	DHRS3	0.800395538	4.78E-36
TGCT	Cell metabolism gene	ANG	ME3	0.806234101	6.19E-37
TGCT	Cell metabolism gene	ANG	SLC44A3	0.814956494	2.56E-38
TGCT	Cell metabolism gene	ANG	DIO3	0.820766365	2.78E-39
TGCT	Cell metabolism gene	ANG	FMOD	0.823091791	1.12E-39
TGCT	Cell metabolism gene	ANG	AGT	0.82885836	1.11E-40
TGCT	Cell metabolism gene	ANG	F10	0.83153568	3.67E-41
TGCT	Cell metabolism gene	ANG	SLC44A4	0.832050504	2.96E-41
TGCT	Cell metabolism gene	ANG	SMARCD3	0.847785019	2.88E-44
TGCT	CGC	ANG	PDGFRA	0.830518954	5.59E-41
TGCT	Epifactor	ANG	PHC2	0.835911791	5.78E-42
TGCT	Epifactor	ANG	SMARCD3	0.847785019	2.88E-44
TGCT	IUPHAR	ANG	MMP23B	0.800262602	5.00E-36
TGCT	IUPHAR	ANG	FCGRT	0.800696809	4.31E-36
TGCT	IUPHAR	ANG	MAPK10	0.801250361	3.56E-36
TGCT	IUPHAR	ANG	SPTLC3	0.801555938	3.20E-36
TGCT	IUPHAR	ANG	XPNPEP2	0.81043207	1.36E-37
TGCT	IUPHAR	ANG	SLC44A3	0.814956494	2.56E-38
TGCT	IUPHAR	ANG	FZD2	0.81957266	4.42E-39
TGCT	IUPHAR	ANG	DIO3	0.820766365	2.78E-39
TGCT	IUPHAR	ANG	PDGFRA	0.830518954	5.59E-41
TGCT	IUPHAR	ANG	F10	0.83153568	3.67E-41
TGCT	IUPHAR	ANG	SLC44A4	0.832050504	2.96E-41
TGCT	IUPHAR	ANG	IL17RC	0.835874218	5.87E-42
TGCT	Kinase	ANG	MAPK10	0.801250361	3.56E-36
TGCT	Kinase	ANG	PDGFRA	0.830518954	5.59E-41
TGCT	TF	ANG	SLC2A4RG	0.80347399	1.64E-36
TGCT	TF	ANG	HES1	0.820017708	3.72E-39
TGCT	TF	ANG	OSR1	0.830653772	5.29E-41
TGCT	TF	ANG	MEIS1	0.834126306	1.24E-41
TGCT	TF	ANG	ZBTB47	0.834648321	9.90E-42
TGCT	TSG	ANG	MAPK10	0.801250361	3.56E-36
TGCT	TSG	ANG	IGFBP4	0.80687362	4.93E-37
TGCT	TSG	ANG	RHOB	0.816807591	1.27E-38
TGCT	TSG	ANG	SEC14L2	0.819478651	4.58E-39
UVM	Cell metabolism gene	ANG	PLCD1	0.827697663	2.91E-21
UVM	Epifactor	ANG	BRPF1	0.81719021	2.37E-20
UVM	IUPHAR	ANG	BRPF1	0.81719021	2.37E-20
UVM	IUPHAR	ANG	PLCD1	0.827697663	2.91E-21
UVM	IUPHAR	ANG	OGG1	0.828047589	2.71E-21
UVM	TF	ANG	ZNF835	0.809465654	1.02E-19
UVM	TSG	ANG	PLCD1	0.827697663	2.91E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	ANG	RNASE2	2.61632889147342	0.00127825845990135
HNSC	ANG	RNASE2	-1.22331858003559	0.00540290265007571
LUSC	ANG	RNASE2	-2.08224432276704	0.00684597527910204
ESCA	ANG	RNASE2	-1.96005491716511	0.009765625
ESCA	ANG	TEK	-4.62660842127501	0.013671875
UCEC	ANG	TP53	2.03295038376694	0.015625
BLCA	ANG	RNASE2	-1.5784944972415	0.040130615234375
ESCA	ANG	RNASE3	-1.47967114248332	0.0440109840129515
COAD	ANG	RNASE2	-1.5951510974409	0.0463311672210694
PRAD	ANG	RNH1	-3.51726050160996	1.55160441106343e-05
THCA	ANG	RNASE2	-1.67820133810127	1.79479101961734e-07
LUAD	ANG	TEK	-3.06350124532268	3.59910232594763e-11
BRCA	ANG	TEK	-1.6632249483129	4.10483912789294e-23
LUSC	ANG	RNH1	-3.1575053033761	4.47366733497978e-07
KIRC	ANG	TP53	-1.43050981150632	4.58942580328929e-09
STAD	ANG	RNASE2	-2.88404466037971	5.4334755986929e-05
KICH	ANG	TEK	-2.30291883829546	5.96046447753906e-08
THCA	ANG	TP53	-1.81960143635647	6.18215597921662e-07
LIHC	ANG	ANXA2	-1.85552952483274	6.54165600156036e-06
BRCA	ANG	RNASE2	-3.93423953878408	6.84230860850505e-12
PRAD	ANG	ANXA2	3.37686663226444	8.40517570249428e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with ANG

ATP6AP1, PTEN, TDGF1, RNH1, TP53, MDM2, ABCG8, PM20D2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
ANG	chr14	21152342	C	A	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152357	G	C	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152394	G	A	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152402	C	T	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152406	T	C	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152412	G	A	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152513	C	T	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152535	G	T	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152553	C	G	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152555	C	T	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152604	C	A	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152699	A	C	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152768	A	G	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152821	G	C	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
ANG	chr14	21152895	T	C	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21152928	A	C	single_nucleotide_variant	Likely_benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ANG	chr14	21161381	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ANG	chr14	21161385	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ANG	chr14	21161484	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ANG	chr14	21161630	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ANG	chr14	21161702	G	A	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ANG	chr14	21161726	G	A	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9\|not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21161761	T	C	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21161776	T	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21161784	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21161785	C	A	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21161785	C	T	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21161817	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161822	C	T	single_nucleotide_variant	Benign/Likely_benign	Amyotrophic_lateral_sclerosis_type_9\|not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
ANG	chr14	21161830	A	T	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161844	A	G	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161845	A	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Amyotrophic_lateral_sclerosis_type_9\|not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161855	C	T	single_nucleotide_variant	Benign	not_specified	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
ANG	chr14	21161878	G	A	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161887	G	A	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161893	G	C	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161912	C	G	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161914	A	T	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161922	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161931	A	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Amyotrophic_lateral_sclerosis_type_9\|not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161947	G	A	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161955	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21161973	A	G	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9\|not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21162046	A	AT	Duplication	Uncertain_significance	Amyotrophic_lateral_sclerosis	SO:0001589\|frameshift_variant,SO:0001627\|intron_variant	SO:0001589\|frameshift_variant,SO:0001627\|intron_variant
ANG	chr14	21162053	T	G	single_nucleotide_variant	Benign	Amyotrophic_lateral_sclerosis_type_9\|not_specified\|not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
ANG	chr14	21162086	A	T	single_nucleotide_variant	Benign/Likely_benign	Amyotrophic_lateral_sclerosis_type_9\|not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
ANG	chr14	21162088	C	T	single_nucleotide_variant	Likely_benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21162091	G	A	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21162129	C	T	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21162130	C	T	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21162132	G	A	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_type_9	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
ANG	chr14	21162164	G	A	single_nucleotide_variant	Likely_benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
ANG	chr14	21162177	C	T	single_nucleotide_variant	Likely_benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21162248	A	C	single_nucleotide_variant	Uncertain_significance	Amyotrophic_lateral_sclerosis_type_9	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21162306	A	G	single_nucleotide_variant	Likely_benign	Amyotrophic_lateral_sclerosis_type_9	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
ANG	chr14	21162456	G	GT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ANG	chr14	21162456	G	GTT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ANG	chr14	21162456	GT	G	Deletion	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
ANG	SARC	chr14	21162109	21162109	T	A	Missense_Mutation		4
ANG	CESC	chr14	21162053	21162053	T	G	Silent		3
ANG	UCEC	chr14	21161742	21161742	G	A	Missense_Mutation	p.V7I	3
ANG	BLCA	chr14	21162089	21162089	G	T	Silent		2
ANG	SARC	chr14	21162109	21162109	T	A	Missense_Mutation	p.V129D	2
ANG	SKCM	chr14	21162093	21162093	T	C	Missense_Mutation	p.F124L	2
ANG	SKCM	chr14	21161793	21161793	G	A	Missense_Mutation	p.A24T	2
ANG	SKCM	chr14	21162055	21162055	C	T	Missense_Mutation	p.S111F	2
ANG	LAML	chr14	20231582	20231582	G	A	Missense_Mutation	p.V7I	2
ANG	STAD	chr14	21162101	21162101	C	T	Silent	p.N126N	2
ANG	TGCT	chr14	21162164	21162164	G	A	Silent	p.P147P	2
ANG	PRAD	chr14	21161988	21161988	C	T	Missense_Mutation	p.H89Y	2
ANG	UCEC	chr14	21162122	21162122	T	C	Silent	p.N133	2
ANG	BLCA	chr14	21161760	21161760	G	A	Missense_Mutation		1
ANG	DLBC	chr14	21161931	21161931	A	G	Missense_Mutation	p.I70V	1
ANG	HNSC	chr14	21162089	21162089	G	A	Silent	p.A122A	1
ANG	SKCM	chr14	21162135	21162135	C	T	Missense_Mutation	p.H138Y	1
ANG	LGG	chr14	21161892	21161892	C	T	Missense_Mutation	p.R57W	1
ANG	LIHC	chr14	21162046	21162046	A	T	Missense_Mutation	p.H108L	1
ANG	TGCT	chr14	21162164	21162164	G	A	Silent		1
ANG	MESO	chr14	21161829	21161829	C	A	Missense_Mutation		1
ANG	OV	chr14	20231685	20231685	A	T	Missense_Mutation		1

Copy number variation (CNV) of ANG
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across ANG
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
74633	STAD	TCGA-FP-8211-01A	ANG	chr14	21152917	+	AKR1C3	chr10	5077620	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	ANG	0.00116669191799822	0.032
TGCT	ANG	5.26150521045981e-05	0.0015

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	ANG	0.00144896072062857	0.045
LUAD	ANG	0.0353980230478639	0.99
THCA	ANG	0.0413076662488645	1
LGG	ANG	0.00381010289334344	0.11
BRCA	ANG	7.07694976568383e-06	0.00023
ESCA	ANG	0.000697581995014927	0.022
BLCA	ANG	0.00229031186961156	0.069

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C2678468	Amyotrophic Lateral Sclerosis 9	9	CTD_human;GENOMICS_ENGLAND;UNIPROT
C0002736	Amyotrophic Lateral Sclerosis	1	ORPHANET
C0010093	Corpus Luteum Cyst	1	CTD_human
C0029927	Ovarian Cysts	1	CTD_human