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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: GRB7 (NCBI Gene ID:2886)

Gene Summary

Gene Summary

Gene Information	Gene Name: GRB7
	Gene ID: 2886
	Gene Symbol	GRB7
	Gene ID	2886
	Gene Name	growth factor receptor bound protein 7
	Synonyms	-
	Cytomap	17q12
	Type of Gene	protein-coding
	Description	growth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7
	Modification date	20200313
	UniProtAcc	Q14451

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GRB7	GO:0030335	positive regulation of cell migration	10893408\|12021278

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
GRB7	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'GRB7[title] AND translation [title] AND human.'

Gene	Title	PMID
GRB7	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000309156	37899150	37899307	Frame-shift
ENST00000394209	37899150	37899307	Frame-shift
ENST00000394211	37899150	37899307	Frame-shift
ENST00000309156	37899645	37899723	In-frame
ENST00000394209	37899645	37899723	In-frame
ENST00000394211	37899645	37899723	In-frame
ENST00000309156	37900805	37900916	In-frame
ENST00000394209	37900805	37900916	In-frame
ENST00000394211	37900805	37900916	In-frame
ENST00000309156	37901495	37901576	In-frame
ENST00000394209	37901495	37901576	In-frame
ENST00000394211	37901495	37901576	In-frame
ENST00000309156	37901674	37901791	In-frame
ENST00000394209	37901674	37901791	In-frame
ENST00000394211	37901674	37901791	In-frame
ENST00000309156	37902165	37902253	Frame-shift
ENST00000394209	37902165	37902253	Frame-shift
ENST00000394211	37902165	37902253	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000394209	37899645	37899723	1972	851	928	532	195	221
ENST00000394211	37899645	37899723	2110	692	769	532	195	221
ENST00000309156	37899645	37899723	2260	843	920	532	195	221
ENST00000394209	37900805	37900916	1972	1067	1177	532	267	304
ENST00000394211	37900805	37900916	2110	908	1018	532	267	304
ENST00000309156	37900805	37900916	2260	1059	1169	532	267	304
ENST00000394209	37901495	37901576	1972	1277	1357	532	337	364
ENST00000394211	37901495	37901576	2110	1118	1198	532	337	364
ENST00000309156	37901495	37901576	2260	1269	1349	532	337	364
ENST00000394209	37901674	37901791	1972	1358	1474	532	364	403
ENST00000394211	37901674	37901791	2110	1199	1315	532	364	403
ENST00000309156	37901674	37901791	2260	1350	1466	532	364	403

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	GRB7	2.57684563734882	0.00390625
READ	GRB7	4.00121793802205	0.03125
KIRC	GRB7	-2.08557276759602	1.28432097821042e-12
KICH	GRB7	-1.35886098374196	1.78813934326172e-07
COAD	GRB7	1.93627228443447	2.98023223876954e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	GRB7	2	1	0.0447308207807389	0.293980657430046	0.181878666666667	0.71526999236041	0.010066227079264
LGG	GRB7	2	3	0.0216413026325226	0.482977227798054	0.654515903054449	-4.56975424737264	-4.1956847290954
SKCM	GRB7	2	3	0.0478104805630755	0.465116238079019	0.669439351851852	-0.804220094446802	-0.349431180328222

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
TGCT	GRB7	2	1	0.0400601136430614	0.329289012426423	0.159543315508021	0.928562609856006	1.18228249982576

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with GRB7 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	GRB7	AGRN	0.830724849	1.66E-12
CHOL	CGC	GRB7	WNK2	0.808646845	1.83E-11
CHOL	CGC	GRB7	ELF3	0.831811519	1.46E-12
CHOL	CGC	GRB7	ERBB3	0.892733231	1.75E-16
CHOL	IUPHAR	GRB7	WNK2	0.808646845	1.83E-11
CHOL	IUPHAR	GRB7	CD276	0.827004604	2.55E-12
CHOL	IUPHAR	GRB7	ERBB3	0.892733231	1.75E-16
CHOL	Kinase	GRB7	WNK2	0.808646845	1.83E-11
CHOL	Kinase	GRB7	ERBB3	0.892733231	1.75E-16
CHOL	TF	GRB7	ELF3	0.831811519	1.46E-12
CHOL	TF	GRB7	HNF1B	0.893984352	1.37E-16
CHOL	TSG	GRB7	WNK2	0.808646845	1.83E-11
CHOL	TSG	GRB7	CTDSPL	0.808866821	1.79E-11
CHOL	TSG	GRB7	KRT19	0.817024135	7.65E-12
CHOL	TSG	GRB7	RAB25	0.82372329	3.68E-12
CHOL	TSG	GRB7	DCDC2	0.837589741	7.33E-13
TGCT	Cell metabolism gene	GRB7	HCCS	0.803982389	1.37E-36
TGCT	Cell metabolism gene	GRB7	DNMT3B	0.810642014	1.26E-37
TGCT	Cell metabolism gene	GRB7	PSMD11	0.820803498	2.74E-39
TGCT	Cell metabolism gene	GRB7	PSMD3	0.837037873	3.56E-42
TGCT	Epifactor	GRB7	DNMT3B	0.810642014	1.26E-37
TGCT	TSG	GRB7	DNMT3B	0.810642014	1.26E-37
TGCT	TSG	GRB7	PHB	0.826256098	3.18E-40
THCA	Cell metabolism gene	GRB7	ALDH3B1	0.802407429	6.79E-130
THCA	Cell metabolism gene	GRB7	PROS1	0.81771528	7.75E-139
THCA	Cell metabolism gene	GRB7	PLCD3	0.842216906	4.65E-155
THCA	Cell metabolism gene	GRB7	SDC4	0.845955799	8.87E-158
THCA	CGC	GRB7	FSTL3	0.814312727	8.88E-137
THCA	CGC	GRB7	ELF3	0.81952752	5.96E-140
THCA	CGC	GRB7	SLC34A2	0.82065141	1.20E-140
THCA	CGC	GRB7	ERBB3	0.821724089	2.56E-141
THCA	CGC	GRB7	SDC4	0.845955799	8.87E-158
THCA	IUPHAR	GRB7	GABRB2	0.809704793	4.68E-134
THCA	IUPHAR	GRB7	PTPRE	0.809970791	3.27E-134
THCA	IUPHAR	GRB7	SLC34A2	0.82065141	1.20E-140
THCA	IUPHAR	GRB7	RARG	0.820780957	9.93E-141
THCA	IUPHAR	GRB7	KCNQ3	0.821012565	7.12E-141
THCA	IUPHAR	GRB7	ERBB3	0.821724089	2.56E-141
THCA	IUPHAR	GRB7	GJB3	0.823580528	1.73E-142
THCA	IUPHAR	GRB7	TACSTD2	0.836759342	3.25E-151
THCA	IUPHAR	GRB7	EPHB3	0.839957115	1.89E-153
THCA	IUPHAR	GRB7	PLCD3	0.842216906	4.65E-155
THCA	IUPHAR	GRB7	ITGA3	0.848239812	1.78E-159
THCA	IUPHAR	GRB7	NOD1	0.84921455	3.30E-160
THCA	IUPHAR	GRB7	TMPRSS6	0.865940877	1.18E-173
THCA	Kinase	GRB7	ERBB3	0.821724089	2.56E-141
THCA	Kinase	GRB7	EPHB3	0.839957115	1.89E-153
THCA	TF	GRB7	ELF3	0.81952752	5.96E-140
THCA	TF	GRB7	RARG	0.820780957	9.93E-141
THCA	TSG	GRB7	CAMK2N1	0.807872447	5.39E-133
THCA	TSG	GRB7	PPP1R1B	0.807945542	4.90E-133
THCA	TSG	GRB7	KRT19	0.812184666	1.64E-135
THCA	TSG	GRB7	PDLIM4	0.828915512	6.24E-146
THCA	TSG	GRB7	EPHB3	0.839957115	1.89E-153
THCA	TSG	GRB7	TMPRSS6	0.865940877	1.18E-173
THYM	TSG	GRB7	JUP	0.806265149	3.91E-29
UCS	TSG	GRB7	JUP	0.806265149	3.91E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	GRB7	EGFR	1.32757138391417	0.000102202753672845
LIHC	GRB7	FHL2	1.6251338358169	0.000209845686767642
KICH	GRB7	ERBB3	3.30539124394538	0.0014527440071106
ESCA	GRB7	SRC	1.0077300524118	0.001953125
BLCA	GRB7	PTK2	-1.24244852434456	0.00239944458007812
LIHC	GRB7	EGFR	-1.2230538094017	0.00496795806084514
KIRP	GRB7	ERBB3	1.05673920266283	0.00571200484409928
STAD	GRB7	ERBB2	2.08308782318447	0.00733334058895707
CHOL	GRB7	PTK2	-2.09285679336748	0.0078125
ESCA	GRB7	TEK	-4.62660842127501	0.013671875
BLCA	GRB7	ERBB2	1.70986293820428	0.014068603515625
CHOL	GRB7	ERBB3	1.57010298428629	0.02734375
LUAD	GRB7	RET	-2.17383920637724	0.0278902380223951
KIRP	GRB7	EGFR	1.14056399927375	0.0394268441013992
STAD	GRB7	EPHB1	-5.21269873384179	0.0394268441013992
HNSC	GRB7	CAV1	1.96516854722805	1.49520951708837e-06
PRAD	GRB7	ERBB3	1.1594821213178	1.5966396741243e-08
LIHC	GRB7	PTK2	-1.87535325648584	2.06383403084721e-07
LUAD	GRB7	EPHB1	-2.93922759093794	2.0741790728873e-06
PRAD	GRB7	FHL2	-1.82979561467933	2.19100533620049e-08
KIRC	GRB7	EGFR	1.55836383937799	2.25998111659284e-12
BRCA	GRB7	ERBB3	2.28105620192688	2.73353544828495e-13
LUAD	GRB7	CAV1	-3.06294584300431	3.59849856594825e-11
LUAD	GRB7	TEK	-3.06350124532268	3.59910232594763e-11
KIRC	GRB7	ERBB3	1.53916110157728	3.91927479910437e-06
THCA	GRB7	EPHB1	-2.55178321527736	4.09207132288577e-11
KIRP	GRB7	RET	2.48155495633	4.09781932830811e-08
BRCA	GRB7	TEK	-1.6632249483129	4.10483912789294e-23
BRCA	GRB7	ERBB2	2.10379074903324	4.64802044953281e-07
KIRC	GRB7	RET	4.56498206164407	4.81926317698848e-12
THCA	GRB7	ERBB2	1.02793927266444	5.71717197842929e-07
KICH	GRB7	TEK	-2.30291883829546	5.96046447753906e-08
STAD	GRB7	SRC	1.29268590267835	6.0301274061203e-05
BRCA	GRB7	RET	1.29262215816003	6.3625505327664e-11
KICH	GRB7	ERBB2	-2.13618034410539	6.55651092529297e-06
BRCA	GRB7	SRC	-1.01389608845799	7.35163663752073e-11
STAD	GRB7	PTK2	-3.29131709886752	8.74791294336319e-06
THCA	GRB7	ERBB3	-1.82448909246289	8.9058794211314e-08
LUAD	GRB7	ERBB2	1.65046120667728	8.94245335020896e-05
HNSC	GRB7	ERBB2	-3.64938375773393	9.1349647846073e-09
LUSC	GRB7	CAV1	-2.61693164564285	9.58407745365481e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with GRB7

SFN, LY6G6F, ERBB3, KIT, RND1, RET, ERBB2, PTK2, EPHB1, INSR, NPM1, RPS2, ZBTB16, A1BG, ATP5B, CPNE6, PKM, DYNC1I1, AGAP1, GNB2, TMSB4X, PDHB, FLAD1, DOCK7, MSH2, HADHB, TLE1, KMT2B, FGB, PHAX, SETDB1, CALM1, LAX1, TRIM36, KCTD6, OLIG1, ZNHIT1, GIGYF1, GIGYF2, PDGFRB, SHC1, USP2, PICK1, TGM5, FAM124B, FCHO1, TCF12, TRIM43, CREBRF, STAC3, RSL1D1, MRPS7, MRPS34, MRPS14, RPL6, RPL39P5, RPL39, RPL12, NOC2L, MRPS2, C19orf53, RPF2, MRPS26, RIOK2, C1orf35, PURB, MRPS24, MRPS27, BRIX1, RPP25L, MCAT, MINA, RPL19, MRPS21, MRPS5, MRPS35, MRPS10, RPL32, RPL31, POLR2L, RPL23A, RPL35, NEMF, RIOK3, RPL18, RPL37A, RPL27, RPL15, RPL14, RPL13A, RPL4, RPL10L, RPL10, RPL35A, GRB7, AR, MET, EGFR, ERBB4, FARSA, HDAC2, RBM10, LTV1, PPIL4, STAU1, PTBP1, G3BP2, PSMD3, LUC7L3, CCT7, RPN1, HNRNPM, RBM14-RBM4, RBM14, EIF4B, SDHA, PUF60, HSPA8, CAPRIN1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
GRB7	chr17	37899147	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GRB7	chr17	37899452	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRB7	chr17	37900387	G	A	single_nucleotide_variant	Uncertain_significance	High_myopia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRB7	chr17	37900864	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRB7	chr17	37901569	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRB7	chr17	37901977	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GRB7	chr17	37902027	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
GRB7	SKCM	chr17	37898852	37898852	C	T	Silent	p.S63S	8
GRB7	SKCM	chr17	37898880	37898880	G	A	Missense_Mutation	p.E73K	3
GRB7	HNSC	chr17	37899470	37899470	G	T	Silent	p.V167V	3
GRB7	STAD	chr17	37901173	37901173	G	A	Missense_Mutation	p.R316Q	3
GRB7	BRCA	chr17	37898827	37898827	G	A	Missense_Mutation	p.R55Q	3
GRB7	BRCA	chr17	37899236	37899236	T	A	Missense_Mutation	p.L131Q	3
GRB7	BRCA	chr17	37899253	37899253	G	A	Missense_Mutation	p.A137T	3
GRB7	SKCM	chr17	37898851	37898851	C	T	Missense_Mutation	p.S63F	3
GRB7	UCEC	chr17	37899223	37899223	G	A	Missense_Mutation	p.V127M	3
GRB7	ESCA	chr17	37898911	37898911	T	A	Missense_Mutation		2
GRB7	SARC	chr17	37899243	37899243	G	T	Missense_Mutation		2
GRB7	BLCA	chr17	37901554	37901554	C	G	Missense_Mutation	p.S357C	2
GRB7	UCEC	chr17	37900339	37900339	G	A	Missense_Mutation	p.G227D	2
GRB7	KIRP	chr17	37898588	37898588	A	G	Missense_Mutation	p.S12G	2
GRB7	SKCM	chr17	37902191	37902191	C	T	Silent	p.F432F	2
GRB7	ESCA	chr17	37898928	37898928	A	C	Missense_Mutation		2
GRB7	UCEC	chr17	37901530	37901531	CA	-	Frame_Shift_Del	p.Q350fs	2
GRB7	SKCM	chr17	37901701	37901701	G	A	Silent	p.V373V	2
GRB7	BRCA	chr17	37898674	37898674	G	C	Missense_Mutation	p.K40N	2
GRB7	HNSC	chr17	37898909	37898909	A	C	Silent		2
GRB7	UCEC	chr17	37901539	37901539	G	A	Missense_Mutation	p.R352H	2
GRB7	CHOL	chr17	37899545	37899545	G	T	Missense_Mutation		2
GRB7	SKCM	chr17	37898596	37898596	G	A	Silent	p.P14P	2
GRB7	PAAD	chr17	37901227	37901227	G	A	Missense_Mutation	p.R334H	2
GRB7	SKCM	chr17	37899207	37899207	T	A	Silent	p.G121G	2
GRB7	BRCA	chr17	37899229	37899229	G	C	Missense_Mutation	p.E129Q	2
GRB7	SKCM	chr17	37902204	37902204	T	C	Missense_Mutation	p.S437P	2
GRB7	PAAD	chr17	37899533	37899533	C	T	Silent	p.Y188Y	2
GRB7	SKCM	chr17	37899515	37899515	G	A	Silent	p.R182R	2
GRB7	HNSC	chr17	37900456	37900456	C	A	Missense_Mutation	p.S266Y	2
GRB7	SKCM	chr17	37900842	37900842	G	A	Missense_Mutation	p.E280K	2
GRB7	UCS	chr17	37899524	37899524	C	T	Silent	p.F185F	2
GRB7	SKCM	chr17	37901727	37901727	G	A	Missense_Mutation	p.G382E	2
GRB7	PAAD	chr17	37900913	37900913	C	A	Silent		2
GRB7	ESCA	chr17	37898911	37898911	T	A	Missense_Mutation	p.I106N	2
GRB7	LIHC	chr17	37902437	37902437	G	T	Missense_Mutation		2
GRB7	SKCM	chr17	37899506	37899506	C	T	Silent	p.F179F	2
GRB7	CESC	chr17	37899650	37899650	C	A	Missense_Mutation		2
GRB7	KICH	chr17	37900401	37900401	C	T	Missense_Mutation	p.R248C	2
GRB7	SKCM	chr17	37899717	37899717	C	T	Silent	p.L219L	2
GRB7	ESCA	chr17	37898928	37898928	A	C	Missense_Mutation	p.S112R	2
GRB7	LIHC	chr17	37902252	37902252	G	T	Missense_Mutation		2
GRB7	STAD	chr17	37901173	37901173	G	A	Missense_Mutation		2
GRB7	CESC	chr17	37899685	37899685	G	A	Missense_Mutation		2
GRB7	SKCM	chr17	37898921	37898921	C	T	Silent	p.G86G	2
GRB7	THCA	chr17	37901566	37901566	C	T	Missense_Mutation	p.S361F	2
GRB7	PRAD	chr17	37898891	37898891	T	G	Missense_Mutation	p.S76R	2
GRB7	BLCA	chr17	37899524	37899524	C	A	Missense_Mutation		2
GRB7	CESC	chr17	37901738	37901738	G	A	Missense_Mutation		2
GRB7	KIRP	chr17	37898588	37898588	A	G	Missense_Mutation	p.S35G	2
GRB7	PAAD	chr17	37899533	37899533	C	T	Silent		2
GRB7	BLCA	chr17	37901234	37901234	C	T	Silent	p.F336F	2
GRB7	SKCM	chr17	37901571	37901571	C	T	Missense_Mutation	p.P363S	1
GRB7	LIHC	chr17	37902437	37902437	G	T	Missense_Mutation	p.K478N	1
GRB7	PAAD	chr17	37901227	37901227	G	A	Missense_Mutation		1
GRB7	STAD	chr17	37900873	37900873	G	A	Missense_Mutation	p.R313H	1
GRB7	STAD	chr17	37900454	37900454	C	A	Silent	p.T265T	1
GRB7	HNSC	chr17	37901747	37901747	C	T	Missense_Mutation		1
GRB7	CESC	chr17	37899685	37899685	G	A	Missense_Mutation	p.D232N	1
GRB7	LUAD	chr17	37902407	37902407	C	T	Missense_Mutation	p.S439F	1
GRB7	PAAD	chr17	37899533	37899533	C	T	Silent	p.Y211Y	1
GRB7	SKCM	chr17	37898819	37898819	G	A	Splice_Site	p.R52_splice	1
GRB7	LIHC	chr17	37900452	37900452	A	-	Frame_Shift_Del	p.T265fs	1
GRB7	SARC	chr17	37903135	37903135	G	T	Silent		1
GRB7	STAD	chr17	37898611	37898611	A	G	Silent	p.P19P	1
GRB7	BLCA	chr17	37898867	37898867	C	T	Silent	p.P68P	1
GRB7	HNSC	chr17	37899470	37899470	G	T	Silent		1
GRB7	CESC	chr17	37901738	37901738	G	A	Missense_Mutation	p.E409K	1
GRB7	KIRP	chr17	37898588	37898588	A	G	Missense_Mutation		1
GRB7	LUAD	chr17	37903087	37903087	C	T	Silent	p.H512H	1
GRB7	PAAD	chr17	37901227	37901227	G	A	Missense_Mutation	p.R357H	1
GRB7	SKCM	chr17	37902393	37902393	C	T	Missense_Mutation	p.P464S	1
GRB7	STAD	chr17	37900454	37900454	C	A	Silent	p.T288T	1
GRB7	ESCA	chr17	37898911	37898911	T	A	Missense_Mutation	p.I83N	1
GRB7	LIHC	chr17	37899662	37899662	A	-	Frame_Shift_Del	p.E201fs	1
GRB7	STAD	chr17	37899172	37899172	G	A	Missense_Mutation	p.D110N	1
GRB7	LGG	chr17	37902408	37902408	C	T	Missense_Mutation	p.L469F	1
GRB7	LUAD	chr17	37902034	37902034	C	T	Silent	p.L421L	1
GRB7	SKCM	chr17	37898848	37898848	C	T	Missense_Mutation	p.T62I	1
GRB7	STAD	chr17	37898828	37898828	A	T	Silent	p.R78R	1
GRB7	ESCA	chr17	37898928	37898928	A	C	Missense_Mutation	p.S89R	1
GRB7	LIHC	chr17	37901499	37901499	G	-	Frame_Shift_Del	p.G339fs	1
GRB7	LIHC	chr17	37899516	37899516	A	-	Frame_Shift_Del	p.K183fs	1
GRB7	TGCT	chr17	37901196	37901196	C	T	Nonsense_Mutation	p.Q347X	1
GRB7	UCS	chr17	37899147	37899147	G	A	Silent		1
GRB7	CHOL	chr17	37899545	37899545	G	T	Missense_Mutation	p.K215N	1
GRB7	LGG	chr17	37901696	37901696	C	A	Missense_Mutation	p.L372M	1
GRB7	LUAD	chr17	37901538	37901538	C	T	Missense_Mutation	p.R352C	1
GRB7	SKCM	chr17	37899512	37899512	C	T	Silent	p.F181F	1
GRB7	ESCA	chr17	37902406	37902407	-	C	Frame_Shift_Ins	p.A468fs	1
GRB7	LIHC	chr17	37898604	37898604	T	-	Frame_Shift_Del	p.L17fs	1
GRB7	TGCT	chr17	37901196	37901196	C	T	Nonsense_Mutation	p.Q324*	1
GRB7	UCS	chr17	37899524	37899524	C	T	Silent	p.F208F	1
GRB7	COAD	chr17	37898577	37898577	C	T	Missense_Mutation	p.P8L	1
GRB7	LGG	chr17	37899152	37899152	T	C	Splice_Site	p.V103_splice	1
GRB7	LUAD	chr17	37898958	37898958	A	T	Missense_Mutation	p.S99C	1
GRB7	SKCM	chr17	37898943	37898943	C	T	Missense_Mutation	p.L94F	1
GRB7	PAAD	chr17	37899218	37899218	G	A	Missense_Mutation	p.R125H	1
GRB7	SKCM	chr17	37899513	37899513	C	T	Missense_Mutation	p.R182W	1
GRB7	STAD	chr17	37900873	37900873	G	A	Missense_Mutation	p.R290H	1
GRB7	GBM	chr17	37902194	37902194	C	A	Missense_Mutation	p.H433Q	1
GRB7	LIHC	chr17	37899714	37899714	C	-	Frame_Shift_Del	p.D218fs	1
GRB7	TGCT	chr17	37901196	37901196	C	T	Nonsense_Mutation		1
GRB7	HNSC	chr17	37901747	37901747	C	T	Missense_Mutation	p.R389W	1
GRB7	COAD	chr17	37900874	37900874	C	T	Silent	p.R290R	1
GRB7	LGG	chr17	37902408	37902408	C	T	Missense_Mutation		1
GRB7	LUAD	chr17	37900375	37900375	G	T	Missense_Mutation	p.R239L	1
GRB7	SKCM	chr17	37898600	37898600	G	A	Missense_Mutation	p.D16N	1
GRB7	STAD	chr17	37900851	37900851	G	A	Missense_Mutation	p.V283M	1
GRB7	BLCA	chr17	37901554	37901554	C	G	Missense_Mutation		1
GRB7	GBM	chr17	37901165	37901165	G	C	Missense_Mutation	p.K313N	1
GRB7	LIHC	chr17	37902178	37902178	C	-	Frame_Shift_Del	p.T428fs	1
GRB7	SKCM	chr17	37898819	37898819	G	A	Silent	p.R52R	1
GRB7	THCA	chr17	37898639	37898639	C	A	Silent		1
GRB7	KICH	chr17	37900401	37900401	C	T	Missense_Mutation		1
GRB7	LUAD	chr17	37900435	37900435	A	G	Missense_Mutation	p.Y259C	1
GRB7	PRAD	chr17	37898891	37898891	T	G	Missense_Mutation	p.S99R	1
GRB7	SKCM	chr17	37903012	37903012	G	A	Silent	p.E487E	1
GRB7	STAD	chr17	37902012	37902012	T	C	Missense_Mutation	p.M414T	1
GRB7	BLCA	chr17	37901234	37901234	C	T	Silent		1
GRB7	GBM	chr17	37903076	37903076	G	A	Missense_Mutation		1
GRB7	LUAD	chr17	37903138	37903138	G	A	Silent	p.R529R	1
GRB7	THCA	chr17	37901566	37901566	C	T	Missense_Mutation		1
GRB7	OV	chr17	37903121	37903121	C	T	Missense_Mutation	p.R524C	1
GRB7	SKCM	chr17	37899245	37899245	G	A	Missense_Mutation	p.R134Q	1
GRB7	PRAD	chr17	37903005	37903005	G	A	Splice_Site	p.S485_splice	1
GRB7	STAD	chr17	37902041	37902041	G	A	Missense_Mutation	p.A424T	1
GRB7	BLCA	chr17	37900352	37900352	G	C	Missense_Mutation		1
GRB7	GBM	chr17	37901165	37901165	G	C	Missense_Mutation		1
GRB7	KIRC	chr17	37899552	37899552	C	T	Missense_Mutation	p.P218S	1
GRB7	LUAD	chr17	37900365	37900365	C	G	Missense_Mutation	p.L236V	1
GRB7	ESCA	chr17	37902406	37902407	-	C	Frame_Shift_Ins	p.L492fs	1
GRB7	LIHC	chr17	37901708	37901708	G	A	Missense_Mutation	p.D399N	1
GRB7	PAAD	chr17	37899218	37899218	G	A	Missense_Mutation		1
GRB7	SKCM	chr17	37898526	37898526	C	T	Missense_Mutation	p.S14F	1
GRB7	STAD	chr17	37901173	37901173	G	A	Missense_Mutation	p.R339Q	1
GRB7	STAD	chr17	37898828	37898828	A	T	Silent	p.R55R	1
GRB7	GBM	chr17	37902175	37902175	G	A	Missense_Mutation		1
GRB7	LUAD	chr17	37898639	37898639	C	T	Missense_Mutation	p.R29W	1
GRB7	ESCA	chr17	37900347	37900347	C	T	Missense_Mutation		1
GRB7	LIHC	chr17	37901211	37901211	T	C	Missense_Mutation	p.W352R	1
GRB7	SKCM	chr17	37903036	37903036	G	A	Missense_Mutation	p.M495I	1
GRB7	PRAD	chr17	37903005	37903005	G	A	Splice_Site	p.S485N	1
GRB7	STAD	chr17	37898611	37898611	A	G	Silent	p.P42P	1
GRB7	STAD	chr17	37901697	37901697	T	C	Missense_Mutation	p.L372P	1
GRB7	HNSC	chr17	37900456	37900456	C	A	Missense_Mutation		1
GRB7	CESC	chr17	37899650	37899650	C	A	Missense_Mutation	p.S220Y	1
GRB7	KIRP	chr17	37903002	37903002	A	C	Splice_Site	.	1
GRB7	LUAD	chr17	37898907	37898907	C	T	Missense_Mutation	p.P82S	1
GRB7	UCEC	chr17	37901530	37901531	CA	-	Frame_Shift_Del	p.A349fs	1

Copy number variation (CNV) of GRB7
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across GRB7
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99269	LUSC	TCGA-60-2715	FBXL20	chr17	37557613	-	GRB7	chr17	37898504	+
99269	LUSC	TCGA-60-2715-01A	FBXL20	chr17	37558426	-	GRB7	chr17	37898505	+
99269	READ	TCGA-AF-A56L	FBXL20	chr17	37557614	-	GRB7	chr17	37898505	+
101356	BLCA	TCGA-HQ-A2OF-01A	GRB7	chr17	37902455	+	ACACA	chr17	35567404	-
79881	BRCA	TCGA-BH-A1EN-01A	GRB7	chr17	37902455	+	ACTN3	chr11	66318710	+
97709	BRCA	TCGA-AR-A0TQ-01A	GRB7	chr17	37902041	+	BRIP1	chr17	59934592	-
34681	BLCA	TCGA-XF-A9SK-01A	GRB7	chr17	37901237	+	CD300E	chr17	72610172	-
99264	OV	TCGA-61-1736-01B	GRB7	chr17	37894386	+	CDK12	chr17	37721013	+
99264	READ	TCGA-AF-A56L-01A	GRB7	chr17	37902455	+	CDK12	chr17	37700502	+
99264	STAD	TCGA-CG-4449	GRB7	chr17	37902455	+	CDK12	chr17	37680926	+
99264	STAD	TCGA-CG-4449-01A	GRB7	chr17	37902455	+	CDK12	chr17	37680927	+
101608	BLCA	TCGA-GU-AATP	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
101608	BRCA	TCGA-C8-A1HK-01A	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
101608	CESC	TCGA-C5-A1M9-01A	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
101608	CESC	TCGA-LP-A5U3-01A	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
101608	CESC	TCGA-LP-A5U3-01A	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
101608	CESC	TCGA-LP-A5U3-01A	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
101608	CESC	TCGA-VS-A9V5	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
101608	CESC	TCGA-VS-A9V5	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
100675	N/A	DL050887	GRB7	chr17	37903538	+	FBXL17	chr5	107440884	-
103189	READ	TCGA-EI-6509	GRB7	chr17	37894645	+	IKZF3	chr17	37988404	-
103189	STAD	TCGA-D7-8573	GRB7	chr17	37894386	+	IKZF3	chr17	37949186	-
103189	STAD	TCGA-FP-7735-01A	GRB7	chr17	37898986	+	IKZF3	chr17	37921231	-
97711	BRCA	TCGA-A2-A0CX-01A	GRB7	chr17	37900460	+	ITGB3	chr17	45351785	+
98049	STAD	TCGA-CG-4466	GRB7	chr17	37894645	+	KRT222	chr17	38816459	-
98049	STAD	TCGA-CG-4466-01A	GRB7	chr17	37894386	+	KRT222	chr17	38816459	-
34681	STAD	TCGA-D7-8573	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-
41073	STAD	TCGA-D7-8573	GRB7	chr17	37900916	+	KRT27	chr17	38933984	-
41073	STAD	TCGA-D7-8573-01A	GRB7	chr17	37900916	+	KRT27	chr17	38950298	-
34681	BRCA	TCGA-AO-A12C-01A	GRB7	chr17	37894645	+	KRT35	chr17	39637007	-
97197	ESCA	TCGA-2H-A9GF	GRB7	chr17	37898709	+	MIEN1	chr17	37886544	-
97197	ESCA	TCGA-M9-A5M8	GRB7	chr17	37894386	+	MIEN1	chr17	37886544	-
97197	ESCA	TCGA-M9-A5M8	GRB7	chr17	37894645	+	MIEN1	chr17	37886544	-
97197	STAD	TCGA-EQ-8122-01A	GRB7	chr17	37898541	+	MIEN1	chr17	37886516	-
99077	BRCA	TCGA-A8-A09I	GRB7	chr17	37894645	+	PGAP3	chr17	37830932	-
99077	BRCA	TCGA-A8-A09I-01A	GRB7	chr17	37894386	+	PGAP3	chr17	37830932	-
99077	BRCA	TCGA-BH-A202	GRB7	chr17	37898709	+	PGAP3	chr17	37842272	-
99077	BRCA	TCGA-BH-A202	GRB7	chr17	37898969	+	PGAP3	chr17	37842272	-
99077	BRCA	TCGA-BH-A202	GRB7	chr17	37899307	+	PGAP3	chr17	37842272	-
99077	BRCA	TCGA-BH-A202-01A	GRB7	chr17	37898708	+	PGAP3	chr17	37842271	-
99077	BRCA	TCGA-BH-A202-01A	GRB7	chr17	37898968	+	PGAP3	chr17	37842271	-
99077	BRCA	TCGA-BH-A202-01A	GRB7	chr17	37899306	+	PGAP3	chr17	37842271	-
99077	ESCA	TCGA-R6-A8W5	GRB7	chr17	37902455	+	PGAP3	chr17	37830932	-
99665	ESCA	TCGA-L5-A88V	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
99665	ESCA	TCGA-L5-A88V	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
99665	ESCA	TCGA-L5-A88V	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
99665	ESCA	TCGA-L5-A88V	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
99665	ESCA	TCGA-L5-A88V-01A	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
88698	BLCA	TCGA-CU-A0YR-01A	GRB7	chr17	37900460	+	PLXDC1	chr17	37224212	-
99282	STAD	TCGA-EQ-8122-01A	GRB7	chr17	37902455	+	PSMD3	chr17	38144936	+
96982	BRCA	TCGA-AR-A24U-01A	GRB7	chr17	37899723	+	SAMHD1	chr20	35547922	-
99287	CESC	TCGA-Q1-A73R	GRB7	chr17	37894645	+	STARD3	chr17	37813260	+
99287	CESC	TCGA-Q1-A73R-01A	GRB7	chr17	37894645	+	STARD3	chr17	37813261	+
99287	STAD	TCGA-BR-7901	GRB7	chr17	37894645	+	STARD3	chr17	37809733	+
76256	STAD	TCGA-BR-A4PE-01A	GRB7	chr17	37895013	+	TCAP	chr17	37822070	+
93090	STAD	TCGA-BR-A4PE-01A	GRB7	chr17	37894386	+	TOP2A	chr17	38548989	-
99295	STAD	TCGA-BR-8381	GRB7	chr17	37894645	+	WIPF2	chr17	38430041	+
99295	STAD	TCGA-BR-8483	GRB7	chr17	37894386	+	WIPF2	chr17	38430041	+
99295	STAD	TCGA-BR-8483	GRB7	chr17	37894386	+	WIPF2	chr17	38433334	+
99295	STAD	TCGA-BR-8483-01A	GRB7	chr17	37894386	+	WIPF2	chr17	38430042	+
99295	STAD	TCGA-BR-8483-01A	GRB7	chr17	37894645	+	WIPF2	chr17	38430042	+
99295	STAD	TCGA-EQ-8122	GRB7	chr17	37902455	+	WIPF2	chr17	38420741	+
99295	STAD	TCGA-EQ-8122-01A	GRB7	chr17	37902455	+	WIPF2	chr17	38420742	+
99269	STAD	TCGA-CG-4466-01A	KAT6A	chr8	41905896	-	GRB7	chr17	37898505	+
99269	OV	TCGA-09-1659	LAMA5	chr20	60907427	-	GRB7	chr17	37903003	+
99269	STAD	TCGA-BR-8486-01A	MED1	chr17	37607291	-	GRB7	chr17	37898505	+
99269	STAD	TCGA-BR-A4PE	MIEN1	chr17	37885937	-	GRB7	chr17	37898504	+
99269	STAD	TCGA-BR-A4PE-01A	MIEN1	chr17	37885938	-	GRB7	chr17	37898505	+
99269	UCEC	TCGA-D1-A16S-01A	MSL1	chr17	38282659	+	GRB7	chr17	37898505	+
99269	LUSC	TCGA-56-A4BX	PGAP3	chr17	37844087	-	GRB7	chr17	37898505	+
99269	UCEC	TCGA-EY-A3QX-01A	PPP1R1B	chr17	37791979	+	GRB7	chr17	37898505	+
99269	STAD	TCGA-HU-8604	RPL41	chr12	56510583	+	GRB7	chr17	37898504	+
99269	BRCA	TCGA-E2-A1LE	STARD3	chr17	37793484	+	GRB7	chr17	37898504	+
99269	BRCA	TCGA-E2-A1LE-01A	STARD3	chr17	37793484	+	GRB7	chr17	37898505	+
99269	UCEC	TCGA-EY-A3QX-01A	STARD3	chr17	37793483	+	GRB7	chr17	37898504	+
99298	BRCA	TCGA-C8-A132-01A	WIPF2	chr17	38375744	+	GRB7	chr17	37901139	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	GRB7	0.00141313607782347	0.04
STAD	GRB7	0.00237962254345471	0.064
LIHC	GRB7	0.00849012759528567	0.22
SARC	GRB7	0.0303487188204106	0.76
LGG	GRB7	0.0330076288435039	0.79
COAD	GRB7	0.0426390573469971	0.98

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	GRB7	0.00141630467103485	0.047
LAML	GRB7	0.0479848772150928	1
PRAD	GRB7	0.013459670869531	0.42
UCS	GRB7	0.0241055224698056	0.72
THYM	GRB7	0.00424965323036572	0.14
READ	GRB7	0.0399026804483136	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	2	CTD_human
C0678222	Breast Carcinoma	2	CTD_human
C1257931	Mammary Neoplasms, Human	2	CTD_human
C4704874	Mammary Carcinoma, Human	2	CTD_human
C0007134	Renal Cell Carcinoma	1	CTD_human
C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
C0205643	Carcinoma, Cribriform	1	CTD_human
C0205644	Carcinoma, Granular Cell	1	CTD_human
C0205645	Adenocarcinoma, Tubular	1	CTD_human
C0242379	Malignant neoplasm of lung	1	CTD_human
C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
C0376358	Malignant neoplasm of prostate	1	CTD_human
C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
C1306837	Papillary Renal Cell Carcinoma	1	CTD_human