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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: GSPT1 (NCBI Gene ID:2935)

Gene Summary

Gene Summary

Gene Information	Gene Name: GSPT1
	Gene ID: 2935
	Gene Symbol	GSPT1
	Gene ID	2935
	Gene Name	G1 to S phase transition 1
	Synonyms	551G9.2\|ETF3A\|GST1\|eRF3a
	Cytomap	16p13.13
	Type of Gene	protein-coding
	Description	eukaryotic peptide chain release factor GTP-binding subunit ERF3AG1 to S phase transition protein 1 homologeukaryotic peptide chain release factor subunit 3aeukaryotic release factor 3a
	Modification date	20200313
	UniProtAcc	P15170

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006415	Translational termination
GO:0008135	Translation factor activity, RNA binding
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GSPT1	GO:0006479	protein methylation	18539146

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'GSPT1[title] AND translation [title] AND human.'

Gene	Title	PMID
GSPT1	Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders	29356495

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000420576	11969617	11969786	Frame-shift
ENST00000563468	11969617	11969786	Frame-shift
ENST00000420576	11969942	11970032	In-frame
ENST00000563468	11969942	11970032	In-frame
ENST00000420576	11971263	11971437	In-frame
ENST00000563468	11971263	11971437	In-frame
ENST00000420576	11976871	11976952	In-frame
ENST00000563468	11976871	11976952	In-frame
ENST00000420576	11980633	11980788	Frame-shift
ENST00000563468	11980633	11980788	Frame-shift
ENST00000420576	11981426	11981607	Frame-shift
ENST00000563468	11981426	11981607	Frame-shift
ENST00000420576	11984918	11984996	In-frame
ENST00000563468	11984918	11984996	In-frame
ENST00000420576	11988810	11988844	Frame-shift
ENST00000563468	11988810	11988844	Frame-shift
ENST00000420576	11990414	11990642	In-frame
ENST00000563468	11990414	11990642	In-frame
ENST00000420576	11991696	11991738	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000420576	11969942	11970032	1620	1292	1381	499	396	426
ENST00000563468	11969942	11970032	1979	1216	1305	499	396	426
ENST00000420576	11971263	11971437	1620	1118	1291	499	338	396
ENST00000563468	11971263	11971437	1979	1042	1215	499	338	396
ENST00000420576	11976871	11976952	1620	1037	1117	499	311	338
ENST00000563468	11976871	11976952	1979	961	1041	499	311	338
ENST00000420576	11984918	11984996	1620	388	465	499	95	120
ENST00000563468	11984918	11984996	1979	312	389	499	95	120
ENST00000420576	11990414	11990642	1620	126	353	499	7	83
ENST00000563468	11990414	11990642	1979	50	277	499	7	83

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P15170	95	120	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	7	83	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	311	338	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	338	396	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	396	426	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	95	120	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	7	83	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	311	338	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	338	396	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	396	426	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
P15170	95	120	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01059
P15170	7	83	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01059
P15170	95	120	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01059
P15170	7	83	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01059
P15170	7	83	81	88	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P15170	7	83	81	88	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P15170	7	83	81	88	Region	Note=G1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01059
P15170	7	83	81	88	Region	Note=G1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01059
P15170	7	83	8	8	Alternative sequence	ID=VSP_042199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P15170	7	83	8	8	Alternative sequence	ID=VSP_042199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	GSPT1	1.07187187610031	0.000163107625527599
BRCA	GSPT1	2.24014219081575	2.76767634190133e-17

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CESC	GSPT1	0.084128231	0.010211487
READ	GSPT1	0.09095383	0.013789338
PCPG	GSPT1	-0.124482624	0.029765652

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with GSPT1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
UVM	Cell metabolism gene	GSPT1	DLAT	0.824689907	5.38E-21
UVM	Epifactor	GSPT1	DDX21	0.82632067	3.86E-21
UVM	IUPHAR	GSPT1	SLC30A6	0.821622922	9.94E-21
UVM	IUPHAR	GSPT1	IDE	0.831849302	1.22E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	GSPT1	UPF1	-1.33899089151335	0.000117696606626909
BLCA	GSPT1	ETF1	-5.5294928877253	0.000125885009765625
LUSC	GSPT1	ETF1	-1.14997231039675	0.000173983823784929
KIRP	GSPT1	RPS7	-3.08161607224061	0.000256400555372238
THCA	GSPT1	N6AMT1	-1.16947119209261	0.000278681868396263
LUAD	GSPT1	GSPT2	-2.14626058601833	0.000586888531715471
PRAD	GSPT1	EEF1G	1.04301780897756	0.00116785923777763
CHOL	GSPT1	PABPC1	-4.56272528815353	0.00390625
LIHC	GSPT1	UPF1	-1.92491321082533	0.00427166918402987
PRAD	GSPT1	RPS7	2.19690532093525	0.00482349779780149
ESCA	GSPT1	RPL15	1.76629417535644	0.0048828125
KIRC	GSPT1	ETF1	-2.84641542192603	0.00644033795389533
KICH	GSPT1	RPS7	2.35513673345303	0.00672554969787598
HNSC	GSPT1	GSPT2	1.05919071999191	0.00965754519575058
BLCA	GSPT1	PABPC1	1.31485302792746	0.0180816650390625
LUAD	GSPT1	SMG1	-1.40175658670625	0.0301695351050489
KIRP	GSPT1	EEF1G	-2.05417074227368	0.0375871751457453
LUSC	GSPT1	GSPT2	-1.07022135846535	0.0407076861351475
LUAD	GSPT1	ETF1	-2.01649649887837	2.27155024792558e-09
LIHC	GSPT1	PABPC1	-1.72076961362188	2.98009622125841e-06
PRAD	GSPT1	UPF1	1.18312136515194	3.77428293642232e-05
KIRC	GSPT1	GSPT2	-2.00602131161654	4.95376546353503e-10
COAD	GSPT1	RPS7	1.80899366786773	5.1647424697876e-05
PRAD	GSPT1	PABPC1	-2.10200318363476	8.55379952759014e-07
KIRP	GSPT1	GSPT2	-6.94360025987246	9.0546440333128e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with GSPT1

BIRC2, XIAP, ETF1, PABPC1, BECN1, ELAVL1, HHV8GK18_gp81, UBR5, ATXN1, HINFP, SPTAN1, DHX16, CCT2, UPF1, RBM8A, SMG1, PIK3R1, ATG7, ATP6V1C1, CTTN, IDE, RDX, GSPT2, RTF1, SNX2, ABCE1, EEF2, EIF4B, MCM5, SNX1, PABPC4, RUVBL1, NTRK1, KRAS, XPO1, SNW1, DPPA4, CDH1, CRBN, DDB1, CHRM4, VBP1, TRIM25, EGLN3, COPE, UBE2M, EFTUD2, PIH1D1, BPLF1, MYC, NR2C2, GBF1, DCAF15, GEM, BIRC3, STAU1, PLEKHA4, PINK1, ARHGAP23, nsp5ab, MAFB, C18orf8, MKRN1, TP53, TMEM184A, PROSER2, GTF2E2, nsp12, nsp13, nsp14, nsp2,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
GSPT1	ESCA	chr16	12009530	12009531	-	CCG	In_Frame_Ins	p.15_16insA	7
GSPT1	COAD	chr16	12009279	12009279	A	G	Missense_Mutation	p.V100A	5
GSPT1	BRCA	chr16	12009404	12009404	C	T	Silent	p.R58	4
GSPT1	BRCA	chr16	11980419	11980419	A	G	Missense_Mutation	p.F388L	4
GSPT1	BRCA	chr16	11988808	11988809	-	A	Splice_Site	e5+2	3
GSPT1	LIHC	chr16	11969724	11969724	G	C	Silent		3
GSPT1	LIHC	chr16	11990564	11990564	C	-	Frame_Shift_Del	p.G173fs	3
GSPT1	BRCA	chr16	11971338	11971338	C	G	Missense_Mutation	p.E510Q	3
GSPT1	BRCA	chr16	11976892	11976892	G	A	Missense_Mutation	p.L470F	3
GSPT1	BRCA	chr16	11984967	11984967	G	A	Missense_Mutation	p.T243M	3
GSPT1	LUAD	chr16	12009531	12009539	CCGCCGCCG	-	In_Frame_Del	p.GGGG13del	2
GSPT1	UCEC	chr16	11980636	11980636	C	A	Missense_Mutation	p.E370D	2
GSPT1	UCEC	chr16	11981523	11981523	G	A	Silent	p.T287	2
GSPT1	KIRC	chr16	11971401	11971401	C	T	Missense_Mutation	p.V489I	2
GSPT1	CESC	chr16	11971344	11971344	C	T	Missense_Mutation		2
GSPT1	UCEC	chr16	11990589	11990589	C	T	Missense_Mutation	p.E164K	2
GSPT1	LIHC	chr16	11971379	11971379	G	-	Frame_Shift_Del	p.P496fs	2
GSPT1	CESC	chr16	11984953	11984953	C	G	Missense_Mutation		2
GSPT1	SKCM	chr16	11969761	11969761	T	G	Missense_Mutation	p.K573T	2
GSPT1	PAAD	chr16	11967016	11967016	G	A	Missense_Mutation		2
GSPT1	SKCM	chr16	11967011	11967011	C	T	Missense_Mutation	p.G627R	2
GSPT1	BLCA	chr16	12009530	12009531	-	CCG	In_Frame_Ins	p.16_16G>GG	2
GSPT1	PAAD	chr16	11990584	11990584	T	G	Silent		2
GSPT1	SKCM	chr16	11970009	11970009	G	A	Silent	p.S542S	2
GSPT1	TGCT	chr16	11990539	11990539	C	A	Silent		2
GSPT1	PAAD	chr16	11967016	11967016	G	A	Missense_Mutation	p.A625V	2
GSPT1	SKCM	chr16	11990493	11990493	G	A	Missense_Mutation	p.P196S	2
GSPT1	PAAD	chr16	11990584	11990584	T	G	Silent	p.I165I	2
GSPT1	SKCM	chr16	11990494	11990494	G	A	Silent	p.I195I	2
GSPT1	UCEC	chr16	11979060	11979060	A	G	Missense_Mutation	p.L442P	2
GSPT1	UCEC	chr16	11980450	11980450	C	T	Silent	p.E377	2
GSPT1	COAD	chr16	12009304	12009304	C	A	Missense_Mutation	p.G92C	2
GSPT1	LGG	chr16	11976916	11976916	C	A	Nonsense_Mutation		1
GSPT1	SARC	chr16	11990538	11990538	G	T	Missense_Mutation		1
GSPT1	DLBC	chr16	12009383	12009383	G	C	Missense_Mutation	p.F65L	1
GSPT1	LIHC	chr16	11991860	11991860	A	G	Silent	p.L129L	1
GSPT1	STAD	chr16	11969978	11969985	GCAGCACC	-	Frame_Shift_Del		1
GSPT1	BLCA	chr16	11980398	11980398	G	A	Missense_Mutation		1
GSPT1	HNSC	chr16	11981428	11981428	A	C	Splice_Site	p.L319_splice	1
GSPT1	LUSC	chr16	11979113	11979113	T	C	Silent	p.P286P	1
GSPT1	SARC	chr16	11980642	11980642	G	T	Missense_Mutation		1
GSPT1	DLBC	chr16	11969985	11969985	C	T	Silent	p.A550A	1
GSPT1	LIHC	chr16	12009287	12009287	T	G	Silent	p.P97P	1
GSPT1	STAD	chr16	11979123	11979123	G	A	Missense_Mutation	p.P421L	1
GSPT1	BLCA	chr16	11966987	11966987	C	G	Missense_Mutation		1
GSPT1	LIHC	chr16	12009304	12009304	C	A	Missense_Mutation		1
GSPT1	OV	chr16	11899212	11899212	A	C	Missense_Mutation	p.L3R	1
GSPT1	SARC	chr16	11990466	11990466	G	T	Missense_Mutation		1
GSPT1	ESCA	chr16	11969646	11969646	C	A	Missense_Mutation	p.Q611H	1
GSPT1	BLCA	chr16	11980398	11980398	G	A	Missense_Mutation	p.H395Y	1
GSPT1	KIRC	chr16	11984971	11984971	T	-	Frame_Shift_Del	p.R242fs	1
GSPT1	STAD	chr16	11969978	11969985	GCAGCACC	-	Frame_Shift_Del	p.AVLH550fs	1
GSPT1	LIHC	chr16	11980462	11980462	T	C	Silent		1
GSPT1	OV	chr16	11990467	11990467	C	A	Silent	p.P66	1
GSPT1	ESCA	chr16	12009530	12009531	-	CCG	In_Frame_Ins	p.17in_frame_insG	1
GSPT1	BLCA	chr16	11966987	11966987	C	G	Missense_Mutation	p.E635Q	1
GSPT1	KIRP	chr16	11980375	11980375	A	G	Silent	p.L402L	1
GSPT1	STAD	chr16	11979123	11979123	G	A	Missense_Mutation	p.P283L	1
GSPT1	CESC	chr16	11971344	11971344	C	T	Missense_Mutation	p.E508K	1
GSPT1	LIHC	chr16	12009287	12009287	T	G	Silent		1
GSPT1	ESCA	chr16	11969646	11969646	C	A	Missense_Mutation		1
GSPT1	LIHC	chr16	11969760	11969760	T	-	Frame_Shift_Del	p.K573fs	1
GSPT1	KIRP	chr16	12009529	12009529	T	C	Missense_Mutation	p.S17G	1
GSPT1	STAD	chr16	11969760	11969760	T	-	Frame_Shift_Del	p.S436fs	1
GSPT1	CESC	chr16	11984953	11984953	C	G	Missense_Mutation	p.E248Q	1
GSPT1	LIHC	chr16	11990521	11990521	A	G	Silent		1
GSPT1	ESCA	chr16	11990465	11990465	G	T	Missense_Mutation	p.P205Q	1
GSPT1	LIHC	chr16	11981555	11981555	T	-	Frame_Shift_Del	p.T277fs	1
GSPT1	BLCA	chr16	11980398	11980398	G	A	Missense_Mutation	p.H257Y	1
GSPT1	KIRP	chr16	11990554	11990554	C	A	Missense_Mutation		1
GSPT1	COAD	chr16	11969724	11969724	G	C	Silent	p.V585V	1
GSPT1	LIHC	chr16	11969951	11969951	C	T	Missense_Mutation		1
GSPT1	LIHC	chr16	11981559	11981559	A	-	Frame_Shift_Del	p.G275fs	1
GSPT1	LGG	chr16	11981588	11981589	-	T	Frame_Shift_Ins	p.D265fs	1
GSPT1	LIHC	chr16	11969747	11969747	T	-	Frame_Shift_Del	p.S578fs	1
GSPT1	TGCT	chr16	11990539	11990539	C	A	Silent	p.P180P	1
GSPT1	COAD	chr16	11980440	11980440	G	A	Missense_Mutation	p.P381S	1
GSPT1	LIHC	chr16	11981486	11981486	G	A	Missense_Mutation		1
GSPT1	HNSC	chr16	11981428	11981428	A	C	Missense_Mutation		1
GSPT1	LGG	chr16	11981501	11981501	G	T	Missense_Mutation	p.L295I	1
GSPT1	LIHC	chr16	11980406	11980406	T	-	Frame_Shift_Del	p.K392fs	1
GSPT1	THCA	chr16	11981487	11981487	G	A	Silent		1
GSPT1	PAAD	chr16	11967016	11967016	G	A	Missense_Mutation	p.A487V	1
GSPT1	COAD	chr16	11980780	11980780	T	C	Silent	p.S322S	1
GSPT1	LIHC	chr16	11969772	11969772	C	A	Missense_Mutation		1
GSPT1	SKCM	chr16	11990461	11990461	A	T	Silent	p.G206G	1
GSPT1	HNSC	chr16	11969998	11969998	G	T	Missense_Mutation		1
GSPT1	LGG	chr16	11981588	11981589	-	T	Frame_Shift_Ins	p.H266fs	1
GSPT1	LIHC	chr16	11990488	11990488	T	-	Frame_Shift_Del	p.K197fs	1
GSPT1	PAAD	chr16	11990584	11990584	T	G	Silent	p.I27I	1
GSPT1	LIHC	chr16	11981478	11981478	A	G	Silent	p.S302S	1
GSPT1	SKCM	chr16	11979040	11979040	T	C	Missense_Mutation	p.K449E	1
GSPT1	BLCA	chr16	11980636	11980636	C	A	Missense_Mutation		1
GSPT1	HNSC	chr16	11969699	11969699	G	A	Missense_Mutation		1
GSPT1	LGG	chr16	11981588	11981589	-	T	Frame_Shift_Ins		1
GSPT1	LIHC	chr16	11981470	11981470	G	-	Frame_Shift_Del	p.P305fs	1
GSPT1	READ	chr16	12009277	12009277	C	A	Missense_Mutation	p.G101C	1
GSPT1	LIHC	chr16	11991733	11991750	TTGAACCTAGACAAGAGA	-	Frame_Shift_Del	p.132_134del	1
GSPT1	SKCM	chr16	11980332	11980332	A	T	Missense_Mutation	p.Y417N	1
GSPT1	BLCA	chr16	12009763	12009763	G	A	Missense_Mutation		1
GSPT1	HNSC	chr16	11969699	11969699	G	A	Missense_Mutation	p.R594C	1

Copy number variation (CNV) of GSPT1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across GSPT1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100580	N/A	AF155114	FBXO9	chr6	52962684	+	GSPT1	chr16	11980897	-
100580	OV	TCGA-25-1635-01A	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
100578	BRCA	TCGA-E2-A9RU	GSPT1	chr16	11971263	-	BCAR4	chr16	11914154	-
100578	UCEC	TCGA-SL-A6J9	GSPT1	chr16	11976871	-	BCAR4	chr16	11914154	-
93581	N/A	EC453653	GSPT1	chr16	11997385	-	IGF2BP3	chr7	23396088	-
100580	N/A	BI493857	ITIH5	chr10	7654287	+	GSPT1	chr16	11999216	-
100580	STAD	TCGA-D7-A4Z0-01A	METTL9	chr16	21636436	+	GSPT1	chr16	11991892	-
100580	Non-Cancer	ERR315469	RBM38	chr20	55968389	+	GSPT1	chr16	11991892	-
100580	OV	TCGA-10-0934	TXNDC11	chr16	11836332	-	GSPT1	chr16	11980788	-
100580	OV	TCGA-10-0934-01A	TXNDC11	chr16	11836333	-	GSPT1	chr16	11980788	-
100580	STAD	TCGA-CG-5725	TXNDC11	chr16	11824500	-	GSPT1	chr16	11971437	-
100580	STAD	TCGA-CG-5725-01A	TXNDC11	chr16	11824501	-	GSPT1	chr16	11971437	-
100580	STAD	TCGA-CG-5720	VPS35	chr16	46723042	-	GSPT1	chr16	11991892	-
100587	BLCA	TCGA-XF-AAML-01A	ZC3H7A	chr16	11868092	-	GSPT1	chr16	11976952	-
100587	STAD	TCGA-CD-5803-01A	ZC3H7A	chr16	11857334	-	GSPT1	chr16	11967028	-
100587	UCEC	TCGA-AX-A2H4-01A	ZC3H7A	chr16	11856527	-	GSPT1	chr16	11976952	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
MESO	GSPT1	0.0236692330055214	0.66
TGCT	GSPT1	0.0265505340580924	0.72
THCA	GSPT1	0.0292861330521498	0.76
LIHC	GSPT1	0.0350179341427084	0.88

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	GSPT1	0.00171383413278946	0.057
LAML	GSPT1	0.0398140056963999	1
BRCA	GSPT1	0.00627994621780131	0.2
COAD	GSPT1	0.041854916380211	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source