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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CNOT7 (NCBI Gene ID:29883)

Gene Summary

Gene Summary

Gene Information	Gene Name: CNOT7
	Gene ID: 29883
	Gene Symbol	CNOT7
	Gene ID	29883
	Gene Name	CCR4-NOT transcription complex subunit 7
	Synonyms	CAF-1\|CAF1\|Caf1a\|hCAF-1
	Cytomap	8p22
	Type of Gene	protein-coding
	Description	CCR4-NOT transcription complex subunit 7BTG1-binding factor 1CCR4-associated factor 1carbon catabolite repressor protein (CCR4)-associative factor 1
	Modification date	20200313
	UniProtAcc	Q9UIV1

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CNOT7	GO:0008285	negative regulation of cell proliferation	19276069
Hgene	CNOT7	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	20065043\|21336257

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CNOT7	(67.6 - 355.7]

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Translation Studies in PubMed

We searched PubMed using 'CNOT7[title] AND translation [title] AND human.'

Gene	Title	PMID
CNOT7	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000361272	17089935	17090046	In-frame
ENST00000361272	17092224	17092369	Frame-shift
ENST00000361272	17094720	17094882	In-frame
ENST00000361272	17100500	17100694	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000361272	17089935	17090046	2666	918	1028	285	206	243
ENST00000361272	17094720	17094882	2666	611	772	285	104	157

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9UIV1	206	243	1	285	Chain	ID=PRO_0000212844;Note=CCR4-NOT transcription complex subunit 7
Q9UIV1	104	157	1	285	Chain	ID=PRO_0000212844;Note=CCR4-NOT transcription complex subunit 7
Q9UIV1	206	243	230	230	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9UIV1	104	157	138	138	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with Y-142 and K-149. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:22977175;Dbxref=PMID:22977175
Q9UIV1	104	157	141	141	Mutagenesis	Note=Abolishes interaction with CNOT1. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:22977175;Dbxref=PMID:22977175
Q9UIV1	104	157	142	142	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with K-138 and K-149. T->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:22977175;Dbxref=PMID:22977175
Q9UIV1	104	157	149	149	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with K-138 and Y-142. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:22977175;Dbxref=PMID:22977175
Q9UIV1	206	243	225	225	Mutagenesis	Note=Abolishes RNA deadenylase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19276069;Dbxref=PMID:19276069
Q9UIV1	206	243	230	230	Mutagenesis	Note=Abolishes RNA deadenylase activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19276069;Dbxref=PMID:19276069
Q9UIV1	206	243	241	241	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9UIV1	104	157	103	105	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R
Q9UIV1	104	157	110	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R
Q9UIV1	104	157	123	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R
Q9UIV1	104	157	133	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R
Q9UIV1	104	157	142	144	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R
Q9UIV1	104	157	145	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R
Q9UIV1	104	157	152	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R
Q9UIV1	206	243	209	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R
Q9UIV1	206	243	227	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2D5R

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	CNOT7	-1.0100272557073	2.28966131184287e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	CNOT7	hsa-miR-381-3p	98	0.387624140565317	0.0242104146698383

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRP	CNOT7	-0.072354898	0.003964663
PAAD	CNOT7	-0.364297314	0.007807236

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CNOT7 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	CNOT7	PPP2CB	0.800871176	8.01E-19
ACC	TSG	CNOT7	PPP2CB	0.800871176	8.01E-19
COAD	Epifactor	CNOT7	ELP3	0.802135844	3.29E-75
COAD	IUPHAR	CNOT7	ELP3	0.802135844	3.29E-75
LAML	CGC	CNOT7	TCEA1	0.809181291	2.42E-41
READ	Cell metabolism gene	CNOT7	PPP2R2A	0.811763714	8.36E-26
READ	Cell metabolism gene	CNOT7	AGPAT5	0.874904498	3.29E-34
READ	CGC	CNOT7	LEPROTL1	0.806592193	2.93E-25
READ	CGC	CNOT7	PCM1	0.843029679	1.68E-29
READ	Epifactor	CNOT7	ELP3	0.815731839	3.11E-26
READ	IUPHAR	CNOT7	TNKS	0.80021573	1.31E-24
READ	IUPHAR	CNOT7	ELP3	0.815731839	3.11E-26
READ	TSG	CNOT7	MCPH1	0.859043388	1.01E-31
SKCM	Cell metabolism gene	CNOT7	PPP2R2A	0.822934363	5.63E-118
SKCM	TSG	CNOT7	MCPH1	0.82399977	1.55E-118
TGCT	Cell metabolism gene	CNOT7	AZIN1	0.820222935	3.44E-39
TGCT	CGC	CNOT7	WRN	0.807091781	4.56E-37
TGCT	Epifactor	CNOT7	ZNF217	0.837689883	2.68E-42
TGCT	IUPHAR	CNOT7	FNTA	0.801769016	2.97E-36
TGCT	TF	CNOT7	THAP1	0.809924134	1.64E-37
TGCT	TF	CNOT7	NFXL1	0.811988462	7.70E-38
TGCT	TF	CNOT7	ZNF217	0.837689883	2.68E-42
TGCT	TF	CNOT7	ZBTB39	0.85211085	3.73E-45
THYM	Cell metabolism gene	CNOT7	NUP205	0.802626302	1.06E-28
THYM	Cell metabolism gene	CNOT7	NUPL1	0.806067637	4.13E-29
THYM	Cell metabolism gene	CNOT7	MTMR6	0.815848022	2.53E-30
THYM	Cell metabolism gene	CNOT7	NUP54	0.825172734	1.51E-31
THYM	Cell metabolism gene	CNOT7	UPRT	0.826602252	9.63E-32
THYM	Cell metabolism gene	CNOT7	NUP107	0.828849242	4.73E-32
THYM	Cell metabolism gene	CNOT7	POLR2B	0.838009466	2.33E-33
THYM	Cell metabolism gene	CNOT7	MED17	0.839912015	1.22E-33
THYM	Cell metabolism gene	CNOT7	TGS1	0.852477012	1.34E-35
THYM	CGC	CNOT7	BRCA2	0.805400819	4.97E-29
THYM	CGC	CNOT7	CREB1	0.810081301	1.34E-29
THYM	CGC	CNOT7	FUBP1	0.810584674	1.16E-29
THYM	CGC	CNOT7	SUZ12	0.812269123	7.17E-30
THYM	CGC	CNOT7	ATF1	0.815548145	2.76E-30
THYM	CGC	CNOT7	RB1	0.815878869	2.51E-30
THYM	CGC	CNOT7	MSH2	0.831979102	1.73E-32
THYM	CGC	CNOT7	TRRAP	0.836565792	3.79E-33
THYM	CGC	CNOT7	TCEA1	0.85093093	2.38E-35
THYM	CGC	CNOT7	RAD21	0.86092485	5.06E-37
THYM	CGC	CNOT7	TOP1	0.884450431	1.55E-41
THYM	Epifactor	CNOT7	MAP3K7	0.800835458	1.73E-28
THYM	Epifactor	CNOT7	NIPBL	0.801524178	1.43E-28
THYM	Epifactor	CNOT7	ATAD2B	0.801905998	1.29E-28
THYM	Epifactor	CNOT7	BRCA2	0.805400819	4.97E-29
THYM	Epifactor	CNOT7	TAF2	0.806357533	3.81E-29
THYM	Epifactor	CNOT7	SUZ12	0.812269123	7.17E-30
THYM	Epifactor	CNOT7	UCHL5	0.813158862	5.55E-30
THYM	Epifactor	CNOT7	RB1	0.815878869	2.51E-30
THYM	Epifactor	CNOT7	ACTL6A	0.821684961	4.41E-31
THYM	Epifactor	CNOT7	SMARCAD1	0.822431084	3.51E-31
THYM	Epifactor	CNOT7	ANKRD32	0.830203529	3.06E-32
THYM	Epifactor	CNOT7	RCOR1	0.833683743	9.87E-33
THYM	Epifactor	CNOT7	TRRAP	0.836565792	3.79E-33
THYM	Epifactor	CNOT7	CTR9	0.843815736	3.13E-34
THYM	Epifactor	CNOT7	ING3	0.854773449	5.60E-36
THYM	Epifactor	CNOT7	RBBP4	0.862471454	2.71E-37
THYM	Epifactor	CNOT7	PHF20L1	0.862626009	2.55E-37
THYM	Epifactor	CNOT7	YY1	0.863727956	1.63E-37
THYM	Epifactor	CNOT7	DR1	0.89260816	2.46E-43
THYM	IUPHAR	CNOT7	MAP3K7	0.800835458	1.73E-28
THYM	IUPHAR	CNOT7	ATAD2B	0.801905998	1.29E-28
THYM	IUPHAR	CNOT7	OXSR1	0.81305704	5.71E-30
THYM	IUPHAR	CNOT7	HIPK1	0.825391168	1.41E-31
THYM	IUPHAR	CNOT7	SRPK2	0.833363967	1.10E-32
THYM	IUPHAR	CNOT7	TRRAP	0.836565792	3.79E-33
THYM	IUPHAR	CNOT7	SLC35A3	0.841358597	7.38E-34
THYM	IUPHAR	CNOT7	DYRK1A	0.863590511	1.72E-37
THYM	IUPHAR	CNOT7	TOP1	0.884450431	1.55E-41
THYM	Kinase	CNOT7	MAP3K7	0.800835458	1.73E-28
THYM	Kinase	CNOT7	OXSR1	0.81305704	5.71E-30
THYM	Kinase	CNOT7	HIPK1	0.825391168	1.41E-31
THYM	Kinase	CNOT7	SRPK2	0.833363967	1.10E-32
THYM	Kinase	CNOT7	TRRAP	0.836565792	3.79E-33
THYM	Kinase	CNOT7	DYRK1A	0.863590511	1.72E-37
THYM	TF	CNOT7	ZNF92	0.800928525	1.68E-28
THYM	TF	CNOT7	ZNF207	0.802049406	1.24E-28
THYM	TF	CNOT7	ATF6B	0.802229385	1.18E-28
THYM	TF	CNOT7	HSF2	0.803409043	8.59E-29
THYM	TF	CNOT7	ZNF131	0.803426908	8.55E-29
THYM	TF	CNOT7	ZNF765	0.803536908	8.30E-29
THYM	TF	CNOT7	ZKSCAN4	0.805044423	5.48E-29
THYM	TF	CNOT7	ZNF675	0.806446266	3.72E-29
THYM	TF	CNOT7	ZNF235	0.809927966	1.40E-29
THYM	TF	CNOT7	CREB1	0.810081301	1.34E-29
THYM	TF	CNOT7	ZNF230	0.810527375	1.18E-29
THYM	TF	CNOT7	ATF1	0.815548145	2.76E-30
THYM	TF	CNOT7	SP4	0.826301096	1.06E-31
THYM	TF	CNOT7	RLF	0.827917072	6.36E-32
THYM	TF	CNOT7	ZUFSP	0.830868219	2.47E-32
THYM	TF	CNOT7	ZNF227	0.83505081	6.28E-33
THYM	TF	CNOT7	ZNF776	0.835732178	5.01E-33
THYM	TF	CNOT7	SP3	0.837853355	2.45E-33
THYM	TF	CNOT7	THAP1	0.850186123	3.14E-35
THYM	TF	CNOT7	YY1	0.863727956	1.63E-37
THYM	TF	CNOT7	ZNF143	0.868967476	1.82E-38
THYM	TF	CNOT7	ZNF184	0.87226465	4.37E-39
THYM	TF	CNOT7	CDC5L	0.87538973	1.09E-39
THYM	TF	CNOT7	ELF1	0.891770469	3.83E-43
THYM	TF	CNOT7	DR1	0.89260816	2.46E-43
THYM	TSG	CNOT7	IGF2R	0.803378768	8.66E-29
THYM	TSG	CNOT7	INTS6	0.803430909	8.54E-29
THYM	TSG	CNOT7	BRCA2	0.805400819	4.97E-29
THYM	TSG	CNOT7	SUZ12	0.812269123	7.17E-30
THYM	TSG	CNOT7	CCAR1	0.812390198	6.92E-30
THYM	TSG	CNOT7	RB1	0.815878869	2.51E-30
THYM	TSG	CNOT7	HACE1	0.819118432	9.59E-31
THYM	TSG	CNOT7	MSH2	0.831979102	1.73E-32
THYM	TSG	CNOT7	RANBP9	0.850986155	2.33E-35
THYM	TSG	CNOT7	ING3	0.854773449	5.60E-36
THYM	TSG	CNOT7	LIN9	0.873544711	2.48E-39
UCEC	Cell metabolism gene	CNOT7	AGPAT5	0.824287133	4.69E-51
UCS	Cell metabolism gene	CNOT7	NUP205	0.802626302	1.06E-28
UCS	Cell metabolism gene	CNOT7	NUPL1	0.806067637	4.13E-29
UCS	Cell metabolism gene	CNOT7	MTMR6	0.815848022	2.53E-30
UCS	Cell metabolism gene	CNOT7	NUP54	0.825172734	1.51E-31
UCS	Cell metabolism gene	CNOT7	UPRT	0.826602252	9.63E-32
UCS	Cell metabolism gene	CNOT7	NUP107	0.828849242	4.73E-32
UCS	Cell metabolism gene	CNOT7	POLR2B	0.838009466	2.33E-33
UCS	Cell metabolism gene	CNOT7	MED17	0.839912015	1.22E-33
UCS	Cell metabolism gene	CNOT7	TGS1	0.852477012	1.34E-35
UCS	CGC	CNOT7	BRCA2	0.805400819	4.97E-29
UCS	CGC	CNOT7	CREB1	0.810081301	1.34E-29
UCS	CGC	CNOT7	FUBP1	0.810584674	1.16E-29
UCS	CGC	CNOT7	SUZ12	0.812269123	7.17E-30
UCS	CGC	CNOT7	ATF1	0.815548145	2.76E-30
UCS	CGC	CNOT7	RB1	0.815878869	2.51E-30
UCS	CGC	CNOT7	MSH2	0.831979102	1.73E-32
UCS	CGC	CNOT7	TRRAP	0.836565792	3.79E-33
UCS	CGC	CNOT7	TCEA1	0.85093093	2.38E-35
UCS	CGC	CNOT7	RAD21	0.86092485	5.06E-37
UCS	CGC	CNOT7	TOP1	0.884450431	1.55E-41
UCS	Epifactor	CNOT7	MAP3K7	0.800835458	1.73E-28
UCS	Epifactor	CNOT7	NIPBL	0.801524178	1.43E-28
UCS	Epifactor	CNOT7	ATAD2B	0.801905998	1.29E-28
UCS	Epifactor	CNOT7	BRCA2	0.805400819	4.97E-29
UCS	Epifactor	CNOT7	TAF2	0.806357533	3.81E-29
UCS	Epifactor	CNOT7	SUZ12	0.812269123	7.17E-30
UCS	Epifactor	CNOT7	UCHL5	0.813158862	5.55E-30
UCS	Epifactor	CNOT7	RB1	0.815878869	2.51E-30
UCS	Epifactor	CNOT7	ACTL6A	0.821684961	4.41E-31
UCS	Epifactor	CNOT7	SMARCAD1	0.822431084	3.51E-31
UCS	Epifactor	CNOT7	ANKRD32	0.830203529	3.06E-32
UCS	Epifactor	CNOT7	RCOR1	0.833683743	9.87E-33
UCS	Epifactor	CNOT7	TRRAP	0.836565792	3.79E-33
UCS	Epifactor	CNOT7	CTR9	0.843815736	3.13E-34
UCS	Epifactor	CNOT7	ING3	0.854773449	5.60E-36
UCS	Epifactor	CNOT7	RBBP4	0.862471454	2.71E-37
UCS	Epifactor	CNOT7	PHF20L1	0.862626009	2.55E-37
UCS	Epifactor	CNOT7	YY1	0.863727956	1.63E-37
UCS	Epifactor	CNOT7	DR1	0.89260816	2.46E-43
UCS	IUPHAR	CNOT7	MAP3K7	0.800835458	1.73E-28
UCS	IUPHAR	CNOT7	ATAD2B	0.801905998	1.29E-28
UCS	IUPHAR	CNOT7	OXSR1	0.81305704	5.71E-30
UCS	IUPHAR	CNOT7	HIPK1	0.825391168	1.41E-31
UCS	IUPHAR	CNOT7	SRPK2	0.833363967	1.10E-32
UCS	IUPHAR	CNOT7	TRRAP	0.836565792	3.79E-33
UCS	IUPHAR	CNOT7	SLC35A3	0.841358597	7.38E-34
UCS	IUPHAR	CNOT7	DYRK1A	0.863590511	1.72E-37
UCS	IUPHAR	CNOT7	TOP1	0.884450431	1.55E-41
UCS	Kinase	CNOT7	MAP3K7	0.800835458	1.73E-28
UCS	Kinase	CNOT7	OXSR1	0.81305704	5.71E-30
UCS	Kinase	CNOT7	HIPK1	0.825391168	1.41E-31
UCS	Kinase	CNOT7	SRPK2	0.833363967	1.10E-32
UCS	Kinase	CNOT7	TRRAP	0.836565792	3.79E-33
UCS	Kinase	CNOT7	DYRK1A	0.863590511	1.72E-37
UCS	TF	CNOT7	ZNF92	0.800928525	1.68E-28
UCS	TF	CNOT7	ZNF207	0.802049406	1.24E-28
UCS	TF	CNOT7	ATF6B	0.802229385	1.18E-28
UCS	TF	CNOT7	HSF2	0.803409043	8.59E-29
UCS	TF	CNOT7	ZNF131	0.803426908	8.55E-29
UCS	TF	CNOT7	ZNF765	0.803536908	8.30E-29
UCS	TF	CNOT7	ZKSCAN4	0.805044423	5.48E-29
UCS	TF	CNOT7	ZNF675	0.806446266	3.72E-29
UCS	TF	CNOT7	ZNF235	0.809927966	1.40E-29
UCS	TF	CNOT7	CREB1	0.810081301	1.34E-29
UCS	TF	CNOT7	ZNF230	0.810527375	1.18E-29
UCS	TF	CNOT7	ATF1	0.815548145	2.76E-30
UCS	TF	CNOT7	SP4	0.826301096	1.06E-31
UCS	TF	CNOT7	RLF	0.827917072	6.36E-32
UCS	TF	CNOT7	ZUFSP	0.830868219	2.47E-32
UCS	TF	CNOT7	ZNF227	0.83505081	6.28E-33
UCS	TF	CNOT7	ZNF776	0.835732178	5.01E-33
UCS	TF	CNOT7	SP3	0.837853355	2.45E-33
UCS	TF	CNOT7	THAP1	0.850186123	3.14E-35
UCS	TF	CNOT7	YY1	0.863727956	1.63E-37
UCS	TF	CNOT7	ZNF143	0.868967476	1.82E-38
UCS	TF	CNOT7	ZNF184	0.87226465	4.37E-39
UCS	TF	CNOT7	CDC5L	0.87538973	1.09E-39
UCS	TF	CNOT7	ELF1	0.891770469	3.83E-43
UCS	TF	CNOT7	DR1	0.89260816	2.46E-43
UCS	TSG	CNOT7	IGF2R	0.803378768	8.66E-29
UCS	TSG	CNOT7	INTS6	0.803430909	8.54E-29
UCS	TSG	CNOT7	BRCA2	0.805400819	4.97E-29
UCS	TSG	CNOT7	SUZ12	0.812269123	7.17E-30
UCS	TSG	CNOT7	CCAR1	0.812390198	6.92E-30
UCS	TSG	CNOT7	RB1	0.815878869	2.51E-30
UCS	TSG	CNOT7	HACE1	0.819118432	9.59E-31
UCS	TSG	CNOT7	MSH2	0.831979102	1.73E-32
UCS	TSG	CNOT7	RANBP9	0.850986155	2.33E-35
UCS	TSG	CNOT7	ING3	0.854773449	5.60E-36
UCS	TSG	CNOT7	LIN9	0.873544711	2.48E-39
UVM	Cell metabolism gene	CNOT7	PPP2R2A	0.80663074	1.71E-19
UVM	IUPHAR	CNOT7	TNKS	0.80478622	2.38E-19
UVM	IUPHAR	CNOT7	FNTA	0.911829865	6.88E-32
UVM	TSG	CNOT7	MCPH1	0.841834405	1.37E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	CNOT7	CNOT10	-2.1943232806481	0.000121572986245155
KIRP	CNOT7	CNOT6L	-3.87663737407518	0.000364991836249828
LUAD	CNOT7	CNOT6L	-2.1633182779043	0.00060389239279426
KIRP	CNOT7	CNOT2	-1.10448855710506	0.00222697434946895
CHOL	CNOT7	CNOT6	-4.83321533739418	0.00390625
HNSC	CNOT7	RQCD1	1.97297540658491	0.00585215220849023
KICH	CNOT7	CNOT3	-1.1461250404339	0.00882232189178467
LUAD	CNOT7	TNKS1BP1	-1.41031433007162	0.0138138989413052
ESCA	CNOT7	TNKS1BP1	-2.3202441985139	0.0185546875
CHOL	CNOT7	TOB1	-1.86894127400263	0.01953125
KIRC	CNOT7	CNOT10	1.29182504470331	2.23846498739956e-10
LIHC	CNOT7	CNOT3	-1.23300348731276	3.17814170396599e-08
BRCA	CNOT7	CNOT3	-2.12666858749727	9.14937084127887e-14

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CNOT7

PABPC1, TOB1, TOB2, CDK4, CDK2, CDK1, BTG1, BTG2, IKBKG, HOXD4, Cnot3, ELAVL1, APP, EPAS1, AGO1, AGO2, CNOT6, BAG3, FBXW11, FOXC2, TNRC6A, MMP7, CAPZA2, RQCD1, CNOT1, CNOT3, TNKS1BP1, CNOT10, RAVER1, CNOT2, CNOT6L, CNOT11, BTG3, RAD54L2, PURB, AURKA, TNRC6C, TNRC6B, APEH, DDX6, B9D2, CNTROB, SCARA3, XPO1, Rpl35, Cnot2, MEX3C, RC3H1, ZFP36, Zfp36, NANOS2, TEX13A, RIBC1, GADD45B, NFKB1, ORF49, CCR4, FBXO7, EGLN3, LSM3, NMI, TSG101, SH3GLB2, PSMC1, MRFAP1L1, PSMC2, TEX11, PIAS1, FHL3, ESR2, RC3H2, ZC3H7A, BMH2, BMH1, DYRK1A, ANXA2R, HTT, PSEN1, TCP11L1, ESR1, ANKRD17, CEP85, AGO3, BBS2, CNOT4, CPEB4, DVL3, EIF4ENIF1, FAM193A, GPBP1, GPBP1L1, HCFC2, HELZ, KIAA0355, N4BP2, PARP14, PRRC2B, PUM1, RNF219, SMG5, SMG7, TDRD3, TMEM57, USP47, YTHDF2, MEX3B, PATL1, PRRC2A, UNK, YTHDF3, TOP3B, RBMS1, YTHDF1, R3HDM2, SAMD4B, MKI67, FHL2, NANOS1, CAPZA1, MAGEA9, TMEM131, CAPZB, PABPN1L, FANCD2OS, FPR1, SULT1C4, MINK1, C12orf57, SCGN, CPEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
CNOT7	chr8	17104142	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
CNOT7	chr8	17104188	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CNOT7	SKCM	chr8	17102580	17102580	G	A	Missense_Mutation	p.R28C	4
CNOT7	ESCA	chr8	17092319	17092319	G	A	Missense_Mutation	p.P175L	3
CNOT7	COAD	chr8	17092286	17092286	C	T	Missense_Mutation	p.R186Q	3
CNOT7	SKCM	chr8	17094725	17094725	G	A	Missense_Mutation	p.H157Y	2
CNOT7	UCEC	chr8	17088235	17088235	C	A	Missense_Mutation	p.Q284H	2
CNOT7	LIHC	chr8	17094743	17094743	C	-	Frame_Shift_Del	p.V151fs	2
CNOT7	UCEC	chr8	17088265	17088265	C	T	Silent	p.G274	2
CNOT7	LUAD	chr8	17090042	17090042	C	A	Missense_Mutation	p.G208V	2
CNOT7	STAD	chr8	17102642	17102642	T	C	Missense_Mutation		2
CNOT7	UCEC	chr8	17100639	17100639	G	A	Missense_Mutation	p.A58V	2
CNOT7	LUAD	chr8	17090038	17090038	T	A	Missense_Mutation	p.L209F	2
CNOT7	STAD	chr8	17102642	17102642	T	C	Missense_Mutation	p.D7G	2
CNOT7	ESCA	chr8	17092319	17092319	G	A	Missense_Mutation		2
CNOT7	STAD	chr8	17100550	17100550	A	G	Missense_Mutation	p.Y88H	2
CNOT7	STAD	chr8	17092325	17092325	T	C	Missense_Mutation	p.N173S	2
CNOT7	STAD	chr8	17094768	17094768	A	C	Silent	p.T142T	2
CNOT7	KIRC	chr8	17102635	17102635	G	T	Missense_Mutation	p.S9R	2
CNOT7	PRAD	chr8	17102627	17102627	A	C	Missense_Mutation	p.I12S	2
CNOT7	THCA	chr8	17092255	17092255	C	G	Missense_Mutation	p.K196N	2
CNOT7	COAD	chr8	17092331	17092331	T	G	Missense_Mutation	p.N171T	1
CNOT7	SKCM	chr8	17090013	17090013	G	A	Silent	p.L218L	1
CNOT7	COAD	chr8	17094735	17094735	C	T	Nonsense_Mutation	p.W153X	1
CNOT7	LUAD	chr8	17092352	17092352	T	C	Missense_Mutation	p.Y164C	1
CNOT7	BLCA	chr8	17094804	17094804	T	G	Silent		1
CNOT7	HNSC	chr8	17088314	17088314	T	C	Missense_Mutation		1
CNOT7	LUAD	chr8	17102606	17102606	T	A	Missense_Mutation	p.N19I	1
CNOT7	BLCA	chr8	17094804	17094804	T	G	Silent	p.G130G	1
CNOT7	HNSC	chr8	17088314	17088314	T	C	Missense_Mutation	p.H258R	1
CNOT7	LUSC	chr8	17090016	17090016	C	G	Missense_Mutation	p.E217Q	1
CNOT7	CESC	chr8	17100547	17100547	G	G	Missense_Mutation		1
CNOT7	COAD	chr8	17089982	17089982	C	T	Missense_Mutation	p.G228E	1
CNOT7	STAD	chr8	17088329	17088329	G	A	Missense_Mutation	p.A253V	1
CNOT7	LGG	chr8	17089983	17089983	C	A	Nonsense_Mutation	p.G228*	1
CNOT7	PRAD	chr8	17089971	17089971	A	G	Silent	p.L232L	1
CNOT7	COAD	chr8	17092275	17092276	-	A	Frame_Shift_Ins	p.P190fs	1
CNOT7	THCA	chr8	17092255	17092255	C	G	Missense_Mutation		1
CNOT7	LGG	chr8	17102653	17102653	C	T	Silent	p.A3A	1
CNOT7	READ	chr8	17102567	17102567	C	T	Missense_Mutation	p.R32Q	1
CNOT7	LGG	chr8	17089983	17089983	C	A	Missense_Mutation		1
CNOT7	COAD	chr8	17092330	17092330	G	A	Silent	p.N171N	1
CNOT7	UCEC	chr8	17094735	17094735	C	G	Missense_Mutation	p.W153C	1
CNOT7	LGG	chr8	17102653	17102653	C	T	Silent		1

Copy number variation (CNV) of CNOT7
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CNOT7
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
51865	N/A	AA173648	CNOT7	chr8	17092300	+	CNOT7	chr8	17090046	-
51865	N/A	AA173958	CNOT7	chr8	17090046	+	CNOT7	chr8	17092300	-
63339	STAD	TCGA-BR-A4CR	CNOT7	chr8	17102544	-	PCM1	chr8	17871472	+
51872	N/A	BM749134	MAT2A	chr2	85766396	+	CNOT7	chr8	17104270	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	CNOT7	0.000218358507325036	0.0061
STAD	CNOT7	0.000461190936118332	0.012
SARC	CNOT7	0.0156886283586539	0.41
LUAD	CNOT7	0.0157347697383842	0.41
KIRP	CNOT7	0.0198285642243618	0.48
LAML	CNOT7	0.0352619444973157	0.81
PAAD	CNOT7	0.0475736089583631	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	CNOT7	0.00828535016007337	0.27

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source