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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: GZMB (NCBI Gene ID:3002)

Gene Summary

Gene Summary

Gene Information	Gene Name: GZMB
	Gene ID: 3002
	Gene Symbol	GZMB
	Gene ID	3002
	Gene Name	granzyme B
	Synonyms	C11\|CCPI\|CGL-1\|CGL1\|CSP-B\|CSPB\|CTLA1\|CTSGL1\|HLP\|SECT
	Cytomap	14q12
	Type of Gene	protein-coding
	Description	granzyme BT-cell serine protease 1-3Ecathepsin G-like 1cytotoxic T-lymphocyte proteinase 2cytotoxic serine protease Bfragmentin 2granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)human lymphocyte protein
	Modification date	20200313
	UniProtAcc	P10144

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GZMB	GO:0017148	negative regulation of translation	29107333

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'GZMB[title] AND translation [title] AND human.'

Gene	Title	PMID
GZMB	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000216341	25101529	25101665	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	GZMB	2.95269816769799	0.00667634152888414
HNSC	GZMB	1.29260501985373	0.0120438377739447
STAD	GZMB	2.55884316349701	0.0148032568395138

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LIHC	GZMB	2	3	0.0102208502657486	0.377152985074627	0.677018390804598	-1.35605731034325	-1.63926347778155

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with GZMB (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	IUPHAR	GZMB	CD247	0.811915254	1.11E-19
BLCA	Cell metabolism gene	GZMB	PSMB9	0.813674779	6.15E-102
BLCA	CGC	GZMB	IL21R	0.809656359	3.56E-100
BLCA	CGC	GZMB	PRF1	0.912411034	1.32E-166
BLCA	IUPHAR	GZMB	HAVCR2	0.807043445	4.74E-99
BLCA	IUPHAR	GZMB	IL21R	0.809656359	3.56E-100
BLCA	IUPHAR	GZMB	CXCR6	0.81263636	1.77E-101
BLCA	IUPHAR	GZMB	PSMB9	0.813674779	6.15E-102
BLCA	IUPHAR	GZMB	IL12RB1	0.818992964	2.45E-104
BLCA	IUPHAR	GZMB	ICOS	0.819992328	8.51E-105
BLCA	IUPHAR	GZMB	CCR5	0.825213882	3.03E-107
BLCA	IUPHAR	GZMB	CXCR3	0.829713461	2.01E-109
BLCA	IUPHAR	GZMB	CD3E	0.842115302	9.07E-116
BLCA	IUPHAR	GZMB	CD2	0.851644961	4.96E-121
BLCA	IUPHAR	GZMB	CTLA4	0.853272683	5.75E-122
BLCA	IUPHAR	GZMB	LAG3	0.854896017	6.54E-123
BLCA	IUPHAR	GZMB	PDCD1	0.86292058	9.35E-128
BLCA	IUPHAR	GZMB	GZMA	0.86807836	4.92E-131
BLCA	IUPHAR	GZMB	PRF1	0.912411034	1.32E-166
BLCA	TF	GZMB	TBX21	0.827680537	1.97E-108
BRCA	Cell metabolism gene	GZMB	IDO1	0.821992763	1.33E-299
BRCA	CGC	GZMB	PRF1	0.875671751	0
BRCA	IUPHAR	GZMB	CTLA4	0.801392123	1.11E-273
BRCA	IUPHAR	GZMB	TIGIT	0.802263904	1.03E-274
BRCA	IUPHAR	GZMB	CD247	0.805537694	1.21E-278
BRCA	IUPHAR	GZMB	CXCR6	0.806070406	2.72E-279
BRCA	IUPHAR	GZMB	GZMA	0.817699598	6.24E-294
BRCA	IUPHAR	GZMB	IDO1	0.821992763	1.33E-299
BRCA	IUPHAR	GZMB	IL2RG	0.837901696	4.94e-322
BRCA	IUPHAR	GZMB	PRF1	0.875671751	0
BRCA	TF	GZMB	TBX21	0.832193295	1.0223638989e-313
CESC	CGC	GZMB	PRF1	0.889751258	3.04E-106
CESC	IUPHAR	GZMB	CD3E	0.803868151	5.15E-71
CESC	IUPHAR	GZMB	TIGIT	0.820301954	3.10E-76
CESC	IUPHAR	GZMB	GZMA	0.838565905	1.05E-82
CESC	IUPHAR	GZMB	PRF1	0.889751258	3.04E-106
CHOL	Cell metabolism gene	GZMB	IDO1	0.832599962	1.33E-12
CHOL	IUPHAR	GZMB	CD3E	0.808710142	1.82E-11
CHOL	IUPHAR	GZMB	TIGIT	0.812995788	1.17E-11
CHOL	IUPHAR	GZMB	IDO1	0.832599962	1.33E-12
CHOL	IUPHAR	GZMB	CD247	0.847082646	2.22E-13
ESCA	CGC	GZMB	PRF1	0.863381852	1.53E-59
ESCA	IUPHAR	GZMB	CD2	0.801323946	3.67E-45
ESCA	IUPHAR	GZMB	CD3E	0.828533929	9.49E-51
ESCA	IUPHAR	GZMB	PDCD1	0.830009065	4.43E-51
ESCA	IUPHAR	GZMB	GZMA	0.859174519	2.34E-58
ESCA	IUPHAR	GZMB	LAG3	0.862220127	3.27E-59
ESCA	IUPHAR	GZMB	PRF1	0.863381852	1.53E-59
ESCA	TF	GZMB	TBX21	0.81082756	5.21E-47
HNSC	CGC	GZMB	PRF1	0.863301462	1.24E-169
HNSC	IUPHAR	GZMB	CD2	0.803523497	3.64E-129
HNSC	IUPHAR	GZMB	CXCR6	0.822329974	3.15E-140
HNSC	IUPHAR	GZMB	PDCD1	0.832383797	1.08E-146
HNSC	IUPHAR	GZMB	GZMA	0.849077501	1.94E-158
HNSC	IUPHAR	GZMB	PRF1	0.863301462	1.24E-169
HNSC	IUPHAR	GZMB	LAG3	0.864303312	1.82E-170
LAML	IUPHAR	GZMB	S1PR5	0.810378001	1.49E-41
LIHC	CGC	GZMB	PRF1	0.836650177	4.03E-112
LIHC	IUPHAR	GZMB	PRF1	0.836650177	4.03E-112
LUAD	IUPHAR	GZMB	GZMA	0.809278911	9.82E-135
LUSC	CGC	GZMB	PRF1	0.843219524	1.19E-150
LUSC	IUPHAR	GZMB	CD3E	0.813200056	1.22E-131
LUSC	IUPHAR	GZMB	CD2	0.824769795	1.55E-138
LUSC	IUPHAR	GZMB	PRF1	0.843219524	1.19E-150
LUSC	IUPHAR	GZMB	CXCR6	0.851110546	2.53E-156
LUSC	IUPHAR	GZMB	GZMA	0.855339343	1.68E-159
MESO	CGC	GZMB	PRF1	0.882690528	1.30E-29
MESO	IUPHAR	GZMB	CD247	0.831865912	1.89E-23
MESO	IUPHAR	GZMB	GZMA	0.849002036	2.86E-25
MESO	IUPHAR	GZMB	PRF1	0.882690528	1.30E-29
OV	CGC	GZMB	PRF1	0.881162565	1.47E-101
OV	IUPHAR	GZMB	ICOS	0.804997692	2.34E-71
OV	IUPHAR	GZMB	IL2RG	0.807431773	4.20E-72
OV	IUPHAR	GZMB	CXCR6	0.821674529	1.07E-76
OV	IUPHAR	GZMB	CD2	0.822669014	4.96E-77
OV	IUPHAR	GZMB	CD3E	0.823284323	3.06E-77
OV	IUPHAR	GZMB	IL2RB	0.824312792	1.37E-77
OV	IUPHAR	GZMB	GZMA	0.873031393	1.92E-97
OV	IUPHAR	GZMB	PRF1	0.881162565	1.47E-101
PCPG	CGC	GZMB	PRF1	0.800358504	5.72E-43
PCPG	IUPHAR	GZMB	PRF1	0.800358504	5.72E-43
SKCM	Cell metabolism gene	GZMB	PSMB9	0.806557484	7.96E-110
SKCM	Cell metabolism gene	GZMB	GNGT2	0.823169198	4.24E-118
SKCM	CGC	GZMB	RHOH	0.805075259	3.98E-109
SKCM	CGC	GZMB	CD74	0.816905229	7.02E-115
SKCM	CGC	GZMB	SOCS1	0.81844664	1.16E-115
SKCM	CGC	GZMB	IL21R	0.820872517	6.64E-117
SKCM	CGC	GZMB	WAS	0.82701873	3.85E-120
SKCM	CGC	GZMB	PTPN6	0.828416767	6.79E-121
SKCM	CGC	GZMB	LCK	0.860864616	1.36E-140
SKCM	CGC	GZMB	PRF1	0.905717357	4.65E-178
SKCM	Epifactor	GZMB	SP140	0.808677793	7.77E-111
SKCM	IUPHAR	GZMB	FGR	0.801833584	1.28E-107
SKCM	IUPHAR	GZMB	PSMB9	0.806557484	7.96E-110
SKCM	IUPHAR	GZMB	SP140	0.808677793	7.77E-111
SKCM	IUPHAR	GZMB	CD6	0.816774718	8.16E-115
SKCM	IUPHAR	GZMB	CD74	0.816905229	7.02E-115
SKCM	IUPHAR	GZMB	CD52	0.817142536	5.33E-115
SKCM	IUPHAR	GZMB	IL15RA	0.818593642	9.79E-116
SKCM	IUPHAR	GZMB	P2RY6	0.820411173	1.15E-116
SKCM	IUPHAR	GZMB	GZMK	0.820536337	9.90E-117
SKCM	IUPHAR	GZMB	IL21R	0.820872517	6.64E-117
SKCM	IUPHAR	GZMB	S1PR4	0.825685589	1.99E-119
SKCM	IUPHAR	GZMB	IL12RB1	0.8267855	5.14E-120
SKCM	IUPHAR	GZMB	CCR5	0.834002659	5.62E-124
SKCM	IUPHAR	GZMB	IL2RB	0.83809405	2.62E-126
SKCM	IUPHAR	GZMB	CD27	0.84589492	6.12E-131
SKCM	IUPHAR	GZMB	ITGAL	0.850454005	9.10E-134
SKCM	IUPHAR	GZMB	TIGIT	0.851777065	1.32E-134
SKCM	IUPHAR	GZMB	GPR171	0.853282802	1.44E-135
SKCM	IUPHAR	GZMB	CD247	0.860236789	3.64E-140
SKCM	IUPHAR	GZMB	LCK	0.860864616	1.36E-140
SKCM	IUPHAR	GZMB	PDCD1	0.872769867	4.10E-149
SKCM	IUPHAR	GZMB	CD3E	0.874604807	1.67E-150
SKCM	IUPHAR	GZMB	IL2RG	0.87517773	6.10E-151
SKCM	IUPHAR	GZMB	CXCR6	0.876612934	4.76E-152
SKCM	IUPHAR	GZMB	CD2	0.878360364	2.04E-153
SKCM	IUPHAR	GZMB	CXCR3	0.881189764	1.12E-155
SKCM	IUPHAR	GZMB	LAG3	0.887820782	3.33E-161
SKCM	IUPHAR	GZMB	GZMA	0.896012873	1.55E-168
SKCM	IUPHAR	GZMB	PRF1	0.905717357	4.65E-178
SKCM	Kinase	GZMB	FGR	0.801833584	1.28E-107
SKCM	Kinase	GZMB	LCK	0.860864616	1.36E-140
SKCM	TF	GZMB	SP140	0.808677793	7.77E-111
SKCM	TF	GZMB	ASCL2	0.809210695	4.31E-111
SKCM	TF	GZMB	ZBED2	0.812005916	1.90E-112
SKCM	TF	GZMB	IRF1	0.853203851	1.61E-135
SKCM	TF	GZMB	TBX21	0.881660753	4.67E-156
SKCM	TSG	GZMB	SOCS1	0.81844664	1.16E-115
SKCM	TSG	GZMB	DOK2	0.821439305	3.38E-117
SKCM	TSG	GZMB	PTPN6	0.828416767	6.79E-121
SKCM	TSG	GZMB	IRF1	0.853203851	1.61E-135
STAD	CGC	GZMB	PRF1	0.805371959	8.37E-104
STAD	IUPHAR	GZMB	PRF1	0.805371959	8.37E-104
STAD	IUPHAR	GZMB	GZMA	0.812112136	7.12E-107
TGCT	Cell metabolism gene	GZMB	IDO1	0.816539873	1.41E-38
TGCT	CGC	GZMB	PRF1	0.881639248	4.34E-52
TGCT	IUPHAR	GZMB	ICOS	0.803351602	1.71E-36
TGCT	IUPHAR	GZMB	TAP1	0.811627517	8.80E-38
TGCT	IUPHAR	GZMB	TIGIT	0.811659448	8.69E-38
TGCT	IUPHAR	GZMB	GZMK	0.815220854	2.32E-38
TGCT	IUPHAR	GZMB	CD3E	0.815977275	1.74E-38
TGCT	IUPHAR	GZMB	IDO1	0.816539873	1.41E-38
TGCT	IUPHAR	GZMB	CD2	0.816547464	1.40E-38
TGCT	IUPHAR	GZMB	CD247	0.818929811	5.66E-39
TGCT	IUPHAR	GZMB	LAG3	0.829531097	8.40E-41
TGCT	IUPHAR	GZMB	CXCR3	0.833983342	1.31E-41
TGCT	IUPHAR	GZMB	PDCD1	0.840893427	6.59E-43
TGCT	IUPHAR	GZMB	GZMA	0.865674556	3.91E-48
TGCT	IUPHAR	GZMB	PRF1	0.881639248	4.34E-52
TGCT	TF	GZMB	BATF	0.834452062	1.08E-41
TGCT	TF	GZMB	TBX21	0.853818489	1.63E-45
THCA	CGC	GZMB	PRF1	0.854646346	2.18E-164
THCA	IUPHAR	GZMB	IL2RG	0.802538793	5.73E-130
THCA	IUPHAR	GZMB	PYHIN1	0.804895935	2.71E-131
THCA	IUPHAR	GZMB	ITGAL	0.805565759	1.13E-131
THCA	IUPHAR	GZMB	ZAP70	0.806954235	1.82E-132
THCA	IUPHAR	GZMB	GZMA	0.833037107	1.13E-148
THCA	IUPHAR	GZMB	PRF1	0.854646346	2.18E-164
THCA	IUPHAR	GZMB	CD247	0.859380228	3.57E-168
THCA	Kinase	GZMB	ZAP70	0.806954235	1.82E-132
THCA	TSG	GZMB	PYHIN1	0.804895935	2.71E-131
UCEC	CGC	GZMB	PRF1	0.87048259	3.53E-63
UCEC	IUPHAR	GZMB	GZMA	0.842019857	3.04E-55
UCEC	IUPHAR	GZMB	PRF1	0.87048259	3.53E-63
UVM	Cell metabolism gene	GZMB	IDO1	0.82144104	1.03E-20
UVM	CGC	GZMB	BCL11B	0.813582563	4.71E-20
UVM	CGC	GZMB	ITK	0.829792059	1.88E-21
UVM	CGC	GZMB	IL21R	0.832101041	1.16E-21
UVM	CGC	GZMB	LCP1	0.853889355	7.92E-24
UVM	CGC	GZMB	IKZF1	0.859446168	1.95E-24
UVM	CGC	GZMB	LCK	0.871721956	7.04E-26
UVM	CGC	GZMB	PRF1	0.891906462	1.32E-28
UVM	Epifactor	GZMB	IKZF1	0.859446168	1.95E-24
UVM	IUPHAR	GZMB	IL12RB1	0.8016123	4.18E-19
UVM	IUPHAR	GZMB	CD52	0.803605555	2.94E-19
UVM	IUPHAR	GZMB	CXCR6	0.808659962	1.18E-19
UVM	IUPHAR	GZMB	P2RY6	0.81103305	7.60E-20
UVM	IUPHAR	GZMB	S1PR4	0.811240302	7.31E-20
UVM	IUPHAR	GZMB	IDO1	0.82144104	1.03E-20
UVM	IUPHAR	GZMB	CD300A	0.82280291	7.86E-21
UVM	IUPHAR	GZMB	CCR5	0.828528869	2.45E-21
UVM	IUPHAR	GZMB	CXCR3	0.828990071	2.23E-21
UVM	IUPHAR	GZMB	ITK	0.829792059	1.88E-21
UVM	IUPHAR	GZMB	TNFRSF1B	0.830135332	1.75E-21
UVM	IUPHAR	GZMB	ZAP70	0.830407483	1.66E-21
UVM	IUPHAR	GZMB	IL21R	0.832101041	1.16E-21
UVM	IUPHAR	GZMB	GZMK	0.834484888	6.96E-22
UVM	IUPHAR	GZMB	IL2RB	0.838708234	2.76E-22
UVM	IUPHAR	GZMB	CD3E	0.838845069	2.68E-22
UVM	IUPHAR	GZMB	CD27	0.840041997	2.05E-22
UVM	IUPHAR	GZMB	PDCD1	0.846720843	4.45E-23
UVM	IUPHAR	GZMB	LAG3	0.848474966	2.94E-23
UVM	IUPHAR	GZMB	CD2	0.853312426	9.14E-24
UVM	IUPHAR	GZMB	IL2RG	0.857399054	3.29E-24
UVM	IUPHAR	GZMB	CD247	0.860791107	1.38E-24
UVM	IUPHAR	GZMB	ITGAL	0.865055821	4.45E-25
UVM	IUPHAR	GZMB	LCK	0.871721956	7.04E-26
UVM	IUPHAR	GZMB	TIGIT	0.874986523	2.75E-26
UVM	IUPHAR	GZMB	GZMA	0.882416238	2.92E-27
UVM	IUPHAR	GZMB	PRF1	0.891906462	1.32E-28
UVM	Kinase	GZMB	ITK	0.829792059	1.88E-21
UVM	Kinase	GZMB	ZAP70	0.830407483	1.66E-21
UVM	Kinase	GZMB	LCK	0.871721956	7.04E-26
UVM	TF	GZMB	BCL11B	0.813582563	4.71E-20
UVM	TF	GZMB	TBX21	0.81415814	4.23E-20
UVM	TF	GZMB	BATF	0.814633582	3.86E-20
UVM	TF	GZMB	IRF1	0.838853721	2.68E-22
UVM	TF	GZMB	IKZF1	0.859446168	1.95E-24
UVM	TSG	GZMB	AIF1	0.822426747	8.47E-21
UVM	TSG	GZMB	RASSF5	0.823702698	6.56E-21
UVM	TSG	GZMB	CXCL10	0.826821809	3.48E-21
UVM	TSG	GZMB	TNFAIP8L2	0.837930706	3.28E-22
UVM	TSG	GZMB	IRF1	0.838853721	2.68E-22
UVM	TSG	GZMB	GBP1	0.844914026	6.78E-23
UVM	TSG	GZMB	IKZF1	0.859446168	1.95E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	GZMB	PRF1	-3.41139845646992	0.000104191367351333
LUSC	GZMB	CD8A	-1.62173785000815	0.000167587292617792
KICH	GZMB	CASP3	-1.33579752215497	0.000187873840332031
LUSC	GZMB	SERPINB9	-1.24865088443788	0.000291380503797954
THCA	GZMB	CD8A	-2.5141593979545	0.000341608043575662
KIRP	GZMB	SHC1	-1.28530866485745	0.000906126573681831
BRCA	GZMB	SERPINB9	1.99488090667985	0.00130086375047006
KICH	GZMB	PRF1	-1.95746195449959	0.00308787822723389
KIRP	GZMB	CD8A	-2.41556883574446	0.00337919034063816
STAD	GZMB	SERPINB9	2.04350356083396	0.00413104705512524
PRAD	GZMB	SRGN	1.24684424614222	0.00752031342713748
READ	GZMB	CASP7	-1.09019031382838	0.03125
ESCA	GZMB	CASP10	1.3556640600505	0.0322265625
KIRP	GZMB	PRF1	-1.71874052986854	0.0433286507613957
UCEC	GZMB	BID	-3.58880101325154	0.046875
UCEC	GZMB	SRGN	2.64122185668164	0.046875
THCA	GZMB	SHC1	-1.92572983257134	1.13787415943499e-05
LUSC	GZMB	GNLY	-2.08652365310446	1.21435313237858e-07
LUSC	GZMB	CASP10	-2.99453377755758	1.36166975509391e-09
KIRC	GZMB	CASP3	-1.13788607606139	1.47934674983518e-09
KIRP	GZMB	CASP3	-1.47815796439668	2.00234353542328e-08
COAD	GZMB	CASP7	-1.32514960363704	2.08616256713867e-07
LUAD	GZMB	PRF1	-1.23030844082535	2.48255276366547e-08
LUSC	GZMB	PRF1	-2.30068436127563	2.7232742434021e-09
LUSC	GZMB	CASP7	-1.29093498862534	3.09303724812157e-05
KIRC	GZMB	SRGN	1.50068401470992	3.19639984652097e-08
LUAD	GZMB	GNLY	-1.08462305785324	3.32622703073417e-05
LUSC	GZMB	SRGN	-2.8161664321849	6.36542835998163e-09
KIRC	GZMB	BID	-1.75099379058383	7.55815385039188e-13

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with GZMB

SERPINB9, SRGN, UBE4A, Hspa1b, Fgfr1, Notch1, Abl1, Hnrnph2, Pabpc1, Brpf1, Itsn1, LMNA, HSPA4, PRKDC, XRCC6, XRCC5, CASP3, PTGES3, BID, CASP7, CASP8, DFFA, CD2AP, TUBA1A, Bid, Casp3, Casp7, Ptges3, Cd2ap, Tuba1a,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
GZMB	chr14	25100364	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GZMB	chr14	25100391	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GZMB	chr14	25101184	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GZMB	chr14	25101548	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GZMB	chr14	25101589	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GZMB	chr14	25101629	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GZMB	chr14	25103302	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
GZMB	CESC	chr14	25100282	25100282	A	G	Missense_Mutation		4
GZMB	PRAD	chr14	25101106	25101106	C	T	Silent	p.E186E	3
GZMB	GBM	chr14	25101153	25101153	G	A	Nonsense_Mutation	p.R171*	3
GZMB	UCS	chr14	25101296	25101296	G	T	Missense_Mutation	p.A123D	3
GZMB	SKCM	chr14	25101071	25101071	G	A	Missense_Mutation	p.S198F	3
GZMB	SKCM	chr14	25101178	25101178	C	T	Silent	p.E162E	2
GZMB	CESC	chr14	25101087	25101087	C	T	Missense_Mutation		2
GZMB	LUAD	chr14	25100341	25100341	G	A	Missense_Mutation	p.P227L	2
GZMB	LAML	chr14	24171052	24171052	G	A	Missense_Mutation	p.A151V	2
GZMB	UCEC	chr14	25101113	25101113	G	C	Missense_Mutation	p.T184S	2
GZMB	LIHC	chr14	25101298	25101298	T	A	Missense_Mutation		2
GZMB	LUAD	chr14	25103412	25103412	T	A	Translation_Start_Site		2
GZMB	UCEC	chr14	25102155	25102155	C	T	Missense_Mutation	p.D57N	2
GZMB	UCEC	chr14	25103356	25103356	A	G	Missense_Mutation	p.I4T	2
GZMB	SARC	chr14	25101548	25101548	G	A	Silent		2
GZMB	LIHC	chr14	25101298	25101298	T	A	Missense_Mutation	p.R122S	2
GZMB	STAD	chr14	25102239	25102239	G	C	Missense_Mutation	p.P29A	2
GZMB	COAD	chr14	25101228	25101228	C	T	Missense_Mutation	p.G146S	2
GZMB	SARC	chr14	25101306	25101306	G	A	Missense_Mutation		2
GZMB	STAD	chr14	25100413	25100413	G	A	Missense_Mutation	p.S203F	2
GZMB	COAD	chr14	25101306	25101306	G	A	Missense_Mutation	p.R120W	2
GZMB	SKCM	chr14	25100298	25100298	C	T	Silent	p.K241K	2
GZMB	HNSC	chr14	25100420	25100420	C	G	Splice_Site	p.G201_splice	2
GZMB	SKCM	chr14	25101557	25101557	G	C	Missense_Mutation	p.N104K	2
GZMB	LUSC	chr14	25102253	25102253	C	T	Missense_Mutation	p.G24E	2
GZMB	LUAD	chr14	25101090	25101090	G	C	Missense_Mutation	p.P192A	2
GZMB	COAD	chr14	25102160	25102160	C	T	Missense_Mutation	p.R55Q	1
GZMB	LUSC	chr14	25102258	25102258	G	A	Silent	p.I22I	1
GZMB	UCEC	chr14	25101092	25101092	T	C	Missense_Mutation	p.D191G	1
GZMB	HNSC	chr14	25100420	25100420	C	G	Missense_Mutation	p.G201R	1
GZMB	SKCM	chr14	25101628	25101628	C	T	Missense_Mutation	p.E81K	1
GZMB	ESCA	chr14	25101215	25101215	G	A	Missense_Mutation	p.T150M	1
GZMB	MESO	chr14	25100363	25100363	C	A	Nonsense_Mutation	p.G220*	1
GZMB	UCEC	chr14	25101547	25101547	C	T	Missense_Mutation	p.D108N	1
GZMB	SKCM	chr14	25101576	25101576	G	A	Missense_Mutation	p.P98L	1
GZMB	CESC	chr14	25101087	25101087	C	T	Missense_Mutation	p.E227K	1
GZMB	LUAD	chr14	25101073	25101073	A	C	Silent	p.T197T	1
GZMB	GBM	chr14	25102156	25102156	G	A	Silent	p.D56D	1
GZMB	SKCM	chr14	25101304	25101304	C	T	Missense_Mutation	p.G75E	1
GZMB	COAD	chr14	25100282	25100282	A	G	Missense_Mutation	p.Y247H	1
GZMB	GBM	chr14	25100297	25100297	T	C	Missense_Mutation	p.K242E	1
GZMB	READ	chr14	25101145	25101145	G	A	Silent	p.C173C	1
GZMB	BLCA	chr14	25101122	25101122	T	C	Missense_Mutation		1
GZMB	LIHC	chr14	25101250	25101250	T	C	Silent		1
GZMB	SKCM	chr14	25102200	25102200	C	T	Missense_Mutation	p.D42N	1
GZMB	COAD	chr14	25101120	25101120	C	T	Missense_Mutation	p.D182N	1
GZMB	LUAD	chr14	25101304	25101304	C	A	Missense_Mutation	p.G75V	1
GZMB	SARC	chr14	25101090	25101090	G	T	Missense_Mutation		1
GZMB	BLCA	chr14	25100311	25100311	A	T	Missense_Mutation		1
GZMB	LIHC	chr14	25102229	25102229	C	T	Missense_Mutation	p.R32H	1
GZMB	SKCM	chr14	25103408	25103408	C	T	Missense_Mutation	p.G21R	1
GZMB	COAD	chr14	25101144	25101144	C	T	Missense_Mutation	p.E174K	1
GZMB	LUAD	chr14	25101305	25101305	C	A	Nonsense_Mutation	p.G75*	1
GZMB	GBM	chr14	25102156	25102156	G	A	Silent		1
GZMB	UCS	chr14	25101296	25101296	G	T	Missense_Mutation		1
GZMB	BLCA	chr14	25101122	25101122	T	C	Missense_Mutation	p.Y181C	1
GZMB	LUAD	chr14	25101178	25101178	C	A	Missense_Mutation	p.E162D	1
GZMB	GBM	chr14	25101153	25101153	G	A	Nonsense_Mutation		1
GZMB	BLCA	chr14	25100311	25100311	A	T	Missense_Mutation	p.V237E	1
GZMB	LIHC	chr14	25101207	25101207	G	-	Frame_Shift_Del	p.L153fs	1
GZMB	LUAD	chr14	25102225	25102225	G	T	Silent	p.P33P	1
GZMB	GBM	chr14	25100297	25100297	T	C	Missense_Mutation		1
GZMB	SARC	chr14	25101090	25101090	G	T	Missense_Mutation	p.P192T	1
GZMB	BLCA	chr14	25101256	25101256	C	T	Silent	p.V136V	1
GZMB	LIHC	chr14	25101580	25101580	G	-	Frame_Shift_Del	p.H97fs	1
GZMB	STAD	chr14	25101617	25101617	C	T	Silent	p.P84P	1
GZMB	COAD	chr14	25101548	25101548	G	A	Silent	p.N107N	1
GZMB	LUAD	chr14	25102224	25102224	A	T	Missense_Mutation	p.Y34N	1
GZMB	HNSC	chr14	25102257	25102257	C	T	Missense_Mutation		1
GZMB	BLCA	chr14	25101100	25101100	G	A	Silent	p.C188C	1
GZMB	LIHC	chr14	25102253	25102253	C	-	Frame_Shift_Del	p.G24fs	1
GZMB	LUAD	chr14	25101280	25101280	C	T	Missense_Mutation	p.G83D	1
GZMB	THYM	chr14	25101238	25101238	G	A	Silent		1
GZMB	COAD	chr14	25101589	25101589	G	C	Missense_Mutation	p.P94A	1
GZMB	LIHC	chr14	25101077	25101077	T	-	Frame_Shift_Del	p.K196fs	1
GZMB	COAD	chr14	25101629	25101629	T	C	Silent	p.K80K	1
GZMB	THYM	chr14	25101238	25101238	G	A	Silent	p.C142C	1
GZMB	HNSC	chr14	25102257	25102257	C	T	Missense_Mutation	p.G23R	1
GZMB	CESC	chr14	25103409	25103409	T	C	Silent		1

Copy number variation (CNV) of GZMB
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across GZMB
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
89918	N/A	CF528869	GIGYF1	chr7	100277413	+	GZMB	chr14	25101096	+
89920	N/A	BG314637	TDO2	chr4	156828925	-	GZMB	chr14	25101153	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	GZMB	0.000433810078536826	0.012
PCPG	GZMB	0.00557422911336201	0.15
BRCA	GZMB	0.0098254778127303	0.26
SARC	GZMB	0.0158980022932229	0.4
SKCM	GZMB	0.0222185754216341	0.53
PAAD	GZMB	0.028508553982403	0.66
TGCT	GZMB	0.0484379625021269	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	GZMB	0.000193511132471205	0.0062
LAML	GZMB	9.97487198878249e-05	0.0033
BRCA	GZMB	0.038815670148076	1
UCEC	GZMB	0.0459066876008216	1
THYM	GZMB	0.0246214507950652	0.74
SARC	GZMB	0.00943282867383986	0.29

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0004352	Autistic Disorder	1	CTD_human
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human