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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: HNRNPD (NCBI Gene ID:3184)

Gene Summary

Gene Summary

Gene Information	Gene Name: HNRNPD
	Gene ID: 3184
	Gene Symbol	HNRNPD
	Gene ID	3184
	Gene Name	heterogeneous nuclear ribonucleoprotein D
	Synonyms	AUF1\|AUF1A\|HNRPD\|P37\|hnRNPD0
	Cytomap	4q21.22
	Type of Gene	protein-coding
	Description	heterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0
	Modification date	20200329
	UniProtAcc	Q14103

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'HNRNPD[title] AND translation [title] AND human.'

Gene	Title	PMID
HNRNPD	LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes	31723020

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000313899	83276456	83276554	5CDS-5UTR
ENST00000313899	83277689	83277836	In-frame
ENST00000313899	83279811	83279973	In-frame
ENST00000313899	83280623	83280792	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000313899	83277689	83277836	3050	1132	1278	355	284	333
ENST00000313899	83279811	83279973	3050	738	899	355	153	207

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	HNRNPD	-3.95797649272358	0.0009765625
COAD	HNRNPD	-6.12601039633597	0.00427913665771485
KICH	HNRNPD	-1.0797746293114	0.00737094879150391
LUAD	HNRNPD	-3.62564314494355	1.52449212829498e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
HNSC	HNRNPD	hsa-miR-146b-5p	99	0.301736238445099	0.00746275988026376
SKCM	HNRNPD	hsa-miR-146b-5p	99	-0.316893865628043	0.0045992203422126
STAD	HNRNPD	hsa-miR-200b-3p	97	-0.301659270692649	0.0102665906314522

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
PRAD	HNRNPD	2	1	0.0391538946185574	0.216008965640659	0.192851298701299	0.44682015767988	0.227556106311383

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LAML	HNRNPD	-0.073334227	0.002245453
LGG	HNRNPD	0.122725307	0.025961558
PCPG	HNRNPD	0.114707083	0.027810668

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with HNRNPD (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	CGC	HNRNPD	FUS	0.808509381	5.39E-41
GBM	CGC	HNRNPD	HNRNPA2B1	0.823901236	8.78E-44
GBM	TSG	HNRNPD	FUS	0.808509381	5.39E-41
TGCT	CGC	HNRNPD	FUS	0.800783961	4.18E-36
TGCT	Epifactor	HNRNPD	H2AFZ	0.812224188	7.06E-38
TGCT	TSG	HNRNPD	FUS	0.800783961	4.18E-36
THYM	Cell metabolism gene	HNRNPD	EDEM1	0.800043865	2.14E-28
THYM	Cell metabolism gene	HNRNPD	PPP2CA	0.801542047	1.43E-28
THYM	Cell metabolism gene	HNRNPD	GALNT7	0.801989087	1.26E-28
THYM	Cell metabolism gene	HNRNPD	LCT	0.802615673	1.07E-28
THYM	Cell metabolism gene	HNRNPD	ELOVL4	0.803053387	9.47E-29
THYM	Cell metabolism gene	HNRNPD	RRM2	0.815183505	3.08E-30
THYM	Cell metabolism gene	HNRNPD	HMMR	0.816792575	1.92E-30
THYM	Cell metabolism gene	HNRNPD	DCP2	0.820704647	5.94E-31
THYM	Cell metabolism gene	HNRNPD	SLC23A1	0.822072681	3.92E-31
THYM	Cell metabolism gene	HNRNPD	GNA15	0.830795221	2.53E-32
THYM	Cell metabolism gene	HNRNPD	PRIM2	0.837512252	2.75E-33
THYM	Cell metabolism gene	HNRNPD	GPC2	0.839821597	1.25E-33
THYM	Cell metabolism gene	HNRNPD	LBR	0.845648656	1.63E-34
THYM	Cell metabolism gene	HNRNPD	TUBA1B	0.84782369	7.45E-35
THYM	Cell metabolism gene	HNRNPD	SEH1L	0.859170883	1.02E-36
THYM	Cell metabolism gene	HNRNPD	PDE7A	0.864754034	1.07E-37
THYM	Cell metabolism gene	HNRNPD	PAFAH2	0.86878913	1.96E-38
THYM	Cell metabolism gene	HNRNPD	MTHFD2L	0.87371276	2.31E-39
THYM	Cell metabolism gene	HNRNPD	ACAT2	0.87914866	1.95E-40
THYM	Cell metabolism gene	HNRNPD	RPIA	0.902044727	1.32E-45
THYM	CGC	HNRNPD	RHOH	0.802205472	1.19E-28
THYM	CGC	HNRNPD	CHIC2	0.802919381	9.82E-29
THYM	CGC	HNRNPD	EZH2	0.807070745	3.13E-29
THYM	CGC	HNRNPD	CTCF	0.807789929	2.56E-29
THYM	CGC	HNRNPD	RFWD3	0.813628737	4.84E-30
THYM	CGC	HNRNPD	IKZF1	0.814570942	3.68E-30
THYM	CGC	HNRNPD	MYB	0.816871322	1.87E-30
THYM	CGC	HNRNPD	STIL	0.820810195	5.76E-31
THYM	CGC	HNRNPD	CDK6	0.824939837	1.62E-31
THYM	CGC	HNRNPD	HNRNPA2B1	0.829534178	3.80E-32
THYM	CGC	HNRNPD	LCK	0.829929233	3.35E-32
THYM	CGC	HNRNPD	LEF1	0.833636742	1.00E-32
THYM	CGC	HNRNPD	BUB1B	0.841046361	8.23E-34
THYM	CGC	HNRNPD	CCND3	0.850703981	2.59E-35
THYM	CGC	HNRNPD	RAP1GDS1	0.862699642	2.47E-37
THYM	CGC	HNRNPD	MLLT11	0.871702737	5.59E-39
THYM	CGC	HNRNPD	BLM	0.873124225	2.99E-39
THYM	CGC	HNRNPD	FNBP1	0.874390596	1.70E-39
THYM	CGC	HNRNPD	TCF3	0.88698902	4.43E-42
THYM	CGC	HNRNPD	EWSR1	0.896391659	3.22E-44
THYM	CGC	HNRNPD	SET	0.912218961	2.49E-48
THYM	CGC	HNRNPD	SFPQ	0.922406161	2.07E-51
THYM	Epifactor	HNRNPD	PPP2CA	0.801542047	1.43E-28
THYM	Epifactor	HNRNPD	CHEK1	0.803008453	9.58E-29
THYM	Epifactor	HNRNPD	H2AFY	0.805670816	4.61E-29
THYM	Epifactor	HNRNPD	HINFP	0.80697832	3.21E-29
THYM	Epifactor	HNRNPD	EZH2	0.807070745	3.13E-29
THYM	Epifactor	HNRNPD	CTCF	0.807789929	2.56E-29
THYM	Epifactor	HNRNPD	HDAC2	0.811410504	9.17E-30
THYM	Epifactor	HNRNPD	CBX2	0.811856669	8.07E-30
THYM	Epifactor	HNRNPD	IKZF1	0.814570942	3.68E-30
THYM	Epifactor	HNRNPD	WHSC1	0.814899089	3.34E-30
THYM	Epifactor	HNRNPD	ANP32B	0.817199323	1.70E-30
THYM	Epifactor	HNRNPD	CENPA	0.81908043	9.70E-31
THYM	Epifactor	HNRNPD	ANP32E	0.819904172	7.57E-31
THYM	Epifactor	HNRNPD	TEX10	0.820515844	6.29E-31
THYM	Epifactor	HNRNPD	CDK2	0.821047779	5.36E-31
THYM	Epifactor	HNRNPD	H1FX	0.821177745	5.15E-31
THYM	Epifactor	HNRNPD	ASF1B	0.821983215	4.03E-31
THYM	Epifactor	HNRNPD	HMGN2	0.825389361	1.41E-31
THYM	Epifactor	HNRNPD	CDK1	0.826247066	1.08E-31
THYM	Epifactor	HNRNPD	NASP	0.827033801	8.41E-32
THYM	Epifactor	HNRNPD	USP7	0.827639164	6.95E-32
THYM	Epifactor	HNRNPD	RAD51	0.828881174	4.68E-32
THYM	Epifactor	HNRNPD	TOP2A	0.830447075	2.83E-32
THYM	Epifactor	HNRNPD	RAD54L	0.830489302	2.80E-32
THYM	Epifactor	HNRNPD	H2AFV	0.832168103	1.62E-32
THYM	Epifactor	HNRNPD	UHRF1	0.83406575	8.70E-33
THYM	Epifactor	HNRNPD	HDAC1	0.834461359	7.64E-33
THYM	Epifactor	HNRNPD	BUB1	0.835908873	4.72E-33
THYM	Epifactor	HNRNPD	HDAC7	0.837947229	2.38E-33
THYM	Epifactor	HNRNPD	LBR	0.845648656	1.63E-34
THYM	Epifactor	HNRNPD	GFI1	0.846478048	1.21E-34
THYM	Epifactor	HNRNPD	MTF2	0.848552817	5.71E-35
THYM	Epifactor	HNRNPD	TAF5	0.852519837	1.32E-35
THYM	Epifactor	HNRNPD	HJURP	0.855445494	4.33E-36
THYM	Epifactor	HNRNPD	H2AFZ	0.858895518	1.13E-36
THYM	Epifactor	HNRNPD	TTK	0.859181122	1.01E-36
THYM	Epifactor	HNRNPD	MTA3	0.862233371	2.99E-37
THYM	Epifactor	HNRNPD	PCNA	0.873171969	2.93E-39
THYM	Epifactor	HNRNPD	CBX3	0.877027104	5.18E-40
THYM	Epifactor	HNRNPD	VRK1	0.898437861	1.03E-44
THYM	Epifactor	HNRNPD	SET	0.912218961	2.49E-48
THYM	Epifactor	HNRNPD	SFPQ	0.922406161	2.07E-51
THYM	Epifactor	HNRNPD	HMGB1	0.935160575	6.36E-56
THYM	IUPHAR	HNRNPD	KCNJ4	0.800534652	1.87E-28
THYM	IUPHAR	HNRNPD	PLK1	0.800998899	1.65E-28
THYM	IUPHAR	HNRNPD	CHEK1	0.803008453	9.58E-29
THYM	IUPHAR	HNRNPD	CCR9	0.804450988	6.46E-29
THYM	IUPHAR	HNRNPD	CYP2U1	0.805708606	4.56E-29
THYM	IUPHAR	HNRNPD	CAMK4	0.80599861	4.21E-29
THYM	IUPHAR	HNRNPD	EZH2	0.807070745	3.13E-29
THYM	IUPHAR	HNRNPD	HDAC2	0.811410504	9.17E-30
THYM	IUPHAR	HNRNPD	CD247	0.812083364	7.56E-30
THYM	IUPHAR	HNRNPD	LAIR1	0.813495474	5.03E-30
THYM	IUPHAR	HNRNPD	CHRNA3	0.814813501	3.43E-30
THYM	IUPHAR	HNRNPD	RRM2	0.815183505	3.08E-30
THYM	IUPHAR	HNRNPD	MELK	0.819220786	9.30E-31
THYM	IUPHAR	HNRNPD	PVRIG	0.819607327	8.28E-31
THYM	IUPHAR	HNRNPD	CDK2	0.821047779	5.36E-31
THYM	IUPHAR	HNRNPD	SLC23A1	0.822072681	3.92E-31
THYM	IUPHAR	HNRNPD	CDK6	0.824939837	1.62E-31
THYM	IUPHAR	HNRNPD	CDK1	0.826247066	1.08E-31
THYM	IUPHAR	HNRNPD	LCK	0.829929233	3.35E-32
THYM	IUPHAR	HNRNPD	TOP2A	0.830447075	2.83E-32
THYM	IUPHAR	HNRNPD	HDAC1	0.834461359	7.64E-33
THYM	IUPHAR	HNRNPD	BUB1	0.835908873	4.72E-33
THYM	IUPHAR	HNRNPD	KIF11	0.836796733	3.51E-33
THYM	IUPHAR	HNRNPD	HDAC7	0.837947229	2.38E-33
THYM	IUPHAR	HNRNPD	TUBB	0.84092105	8.59E-34
THYM	IUPHAR	HNRNPD	BUB1B	0.841046361	8.23E-34
THYM	IUPHAR	HNRNPD	RGS10	0.841302956	7.53E-34
THYM	IUPHAR	HNRNPD	PRKCQ	0.843455572	3.55E-34
THYM	IUPHAR	HNRNPD	TTK	0.859181122	1.01E-36
THYM	IUPHAR	HNRNPD	PDE7A	0.864754034	1.07E-37
THYM	IUPHAR	HNRNPD	PLK4	0.865224316	8.78E-38
THYM	IUPHAR	HNRNPD	PAFAH2	0.86878913	1.96E-38
THYM	IUPHAR	HNRNPD	ACAT2	0.87914866	1.95E-40
THYM	IUPHAR	HNRNPD	VRK1	0.898437861	1.03E-44
THYM	Kinase	HNRNPD	PLK1	0.800998899	1.65E-28
THYM	Kinase	HNRNPD	CHEK1	0.803008453	9.58E-29
THYM	Kinase	HNRNPD	CAMK4	0.80599861	4.21E-29
THYM	Kinase	HNRNPD	MELK	0.819220786	9.30E-31
THYM	Kinase	HNRNPD	CDK2	0.821047779	5.36E-31
THYM	Kinase	HNRNPD	CDK6	0.824939837	1.62E-31
THYM	Kinase	HNRNPD	CDK1	0.826247066	1.08E-31
THYM	Kinase	HNRNPD	LCK	0.829929233	3.35E-32
THYM	Kinase	HNRNPD	BUB1	0.835908873	4.72E-33
THYM	Kinase	HNRNPD	BUB1B	0.841046361	8.23E-34
THYM	Kinase	HNRNPD	PRKCQ	0.843455572	3.55E-34
THYM	Kinase	HNRNPD	TTK	0.859181122	1.01E-36
THYM	Kinase	HNRNPD	PLK4	0.865224316	8.78E-38
THYM	Kinase	HNRNPD	VRK1	0.898437861	1.03E-44
THYM	TF	HNRNPD	ZNF367	0.803588651	8.18E-29
THYM	TF	HNRNPD	FOXM1	0.804266193	6.79E-29
THYM	TF	HNRNPD	HINFP	0.80697832	3.21E-29
THYM	TF	HNRNPD	CTCF	0.807789929	2.56E-29
THYM	TF	HNRNPD	CBX2	0.811856669	8.07E-30
THYM	TF	HNRNPD	IKZF1	0.814570942	3.68E-30
THYM	TF	HNRNPD	MYB	0.816871322	1.87E-30
THYM	TF	HNRNPD	CENPA	0.81908043	9.70E-31
THYM	TF	HNRNPD	NFATC3	0.8239173	2.22E-31
THYM	TF	HNRNPD	TCF7	0.826082298	1.13E-31
THYM	TF	HNRNPD	E2F2	0.827704616	6.80E-32
THYM	TF	HNRNPD	E2F8	0.829057166	4.43E-32
THYM	TF	HNRNPD	LEF1	0.833636742	1.00E-32
THYM	TF	HNRNPD	GFI1	0.846478048	1.21E-34
THYM	TF	HNRNPD	MTF2	0.848552817	5.71E-35
THYM	TF	HNRNPD	TTF1	0.851568949	1.88E-35
THYM	TF	HNRNPD	TCF3	0.88698902	4.43E-42
THYM	TSG	HNRNPD	PLK1	0.800998899	1.65E-28
THYM	TSG	HNRNPD	PPP2CA	0.801542047	1.43E-28
THYM	TSG	HNRNPD	CHEK1	0.803008453	9.58E-29
THYM	TSG	HNRNPD	EZH2	0.807070745	3.13E-29
THYM	TSG	HNRNPD	CTCF	0.807789929	2.56E-29
THYM	TSG	HNRNPD	IKZF1	0.814570942	3.68E-30
THYM	TSG	HNRNPD	RBMX	0.818459726	1.17E-30
THYM	TSG	HNRNPD	CDK2	0.821047779	5.36E-31
THYM	TSG	HNRNPD	CDK6	0.824939837	1.62E-31
THYM	TSG	HNRNPD	E2F2	0.827704616	6.80E-32
THYM	TSG	HNRNPD	HDAC1	0.834461359	7.64E-33
THYM	TSG	HNRNPD	MUS81	0.842486906	4.99E-34
THYM	TSG	HNRNPD	DLEU2	0.850479139	2.82E-35
THYM	TSG	HNRNPD	TTF1	0.851568949	1.88E-35
THYM	TSG	HNRNPD	CHFR	0.860987747	4.93E-37
THYM	TSG	HNRNPD	BLM	0.873124225	2.99E-39
THYM	TSG	HNRNPD	TCF3	0.88698902	4.43E-42
THYM	TSG	HNRNPD	PTPN2	0.930341387	4.06E-54
UCS	Cell metabolism gene	HNRNPD	EDEM1	0.800043865	2.14E-28
UCS	Cell metabolism gene	HNRNPD	PPP2CA	0.801542047	1.43E-28
UCS	Cell metabolism gene	HNRNPD	GALNT7	0.801989087	1.26E-28
UCS	Cell metabolism gene	HNRNPD	LCT	0.802615673	1.07E-28
UCS	Cell metabolism gene	HNRNPD	ELOVL4	0.803053387	9.47E-29
UCS	Cell metabolism gene	HNRNPD	RRM2	0.815183505	3.08E-30
UCS	Cell metabolism gene	HNRNPD	HMMR	0.816792575	1.92E-30
UCS	Cell metabolism gene	HNRNPD	DCP2	0.820704647	5.94E-31
UCS	Cell metabolism gene	HNRNPD	SLC23A1	0.822072681	3.92E-31
UCS	Cell metabolism gene	HNRNPD	GNA15	0.830795221	2.53E-32
UCS	Cell metabolism gene	HNRNPD	PRIM2	0.837512252	2.75E-33
UCS	Cell metabolism gene	HNRNPD	GPC2	0.839821597	1.25E-33
UCS	Cell metabolism gene	HNRNPD	LBR	0.845648656	1.63E-34
UCS	Cell metabolism gene	HNRNPD	TUBA1B	0.84782369	7.45E-35
UCS	Cell metabolism gene	HNRNPD	SEH1L	0.859170883	1.02E-36
UCS	Cell metabolism gene	HNRNPD	PDE7A	0.864754034	1.07E-37
UCS	Cell metabolism gene	HNRNPD	PAFAH2	0.86878913	1.96E-38
UCS	Cell metabolism gene	HNRNPD	MTHFD2L	0.87371276	2.31E-39
UCS	Cell metabolism gene	HNRNPD	ACAT2	0.87914866	1.95E-40
UCS	Cell metabolism gene	HNRNPD	RPIA	0.902044727	1.32E-45
UCS	CGC	HNRNPD	RHOH	0.802205472	1.19E-28
UCS	CGC	HNRNPD	CHIC2	0.802919381	9.82E-29
UCS	CGC	HNRNPD	EZH2	0.807070745	3.13E-29
UCS	CGC	HNRNPD	CTCF	0.807789929	2.56E-29
UCS	CGC	HNRNPD	RFWD3	0.813628737	4.84E-30
UCS	CGC	HNRNPD	IKZF1	0.814570942	3.68E-30
UCS	CGC	HNRNPD	MYB	0.816871322	1.87E-30
UCS	CGC	HNRNPD	STIL	0.820810195	5.76E-31
UCS	CGC	HNRNPD	CDK6	0.824939837	1.62E-31
UCS	CGC	HNRNPD	HNRNPA2B1	0.829534178	3.80E-32
UCS	CGC	HNRNPD	LCK	0.829929233	3.35E-32
UCS	CGC	HNRNPD	LEF1	0.833636742	1.00E-32
UCS	CGC	HNRNPD	BUB1B	0.841046361	8.23E-34
UCS	CGC	HNRNPD	CCND3	0.850703981	2.59E-35
UCS	CGC	HNRNPD	RAP1GDS1	0.862699642	2.47E-37
UCS	CGC	HNRNPD	MLLT11	0.871702737	5.59E-39
UCS	CGC	HNRNPD	BLM	0.873124225	2.99E-39
UCS	CGC	HNRNPD	FNBP1	0.874390596	1.70E-39
UCS	CGC	HNRNPD	TCF3	0.88698902	4.43E-42
UCS	CGC	HNRNPD	EWSR1	0.896391659	3.22E-44
UCS	CGC	HNRNPD	SET	0.912218961	2.49E-48
UCS	CGC	HNRNPD	SFPQ	0.922406161	2.07E-51
UCS	Epifactor	HNRNPD	PPP2CA	0.801542047	1.43E-28
UCS	Epifactor	HNRNPD	CHEK1	0.803008453	9.58E-29
UCS	Epifactor	HNRNPD	H2AFY	0.805670816	4.61E-29
UCS	Epifactor	HNRNPD	HINFP	0.80697832	3.21E-29
UCS	Epifactor	HNRNPD	EZH2	0.807070745	3.13E-29
UCS	Epifactor	HNRNPD	CTCF	0.807789929	2.56E-29
UCS	Epifactor	HNRNPD	HDAC2	0.811410504	9.17E-30
UCS	Epifactor	HNRNPD	CBX2	0.811856669	8.07E-30
UCS	Epifactor	HNRNPD	IKZF1	0.814570942	3.68E-30
UCS	Epifactor	HNRNPD	WHSC1	0.814899089	3.34E-30
UCS	Epifactor	HNRNPD	ANP32B	0.817199323	1.70E-30
UCS	Epifactor	HNRNPD	CENPA	0.81908043	9.70E-31
UCS	Epifactor	HNRNPD	ANP32E	0.819904172	7.57E-31
UCS	Epifactor	HNRNPD	TEX10	0.820515844	6.29E-31
UCS	Epifactor	HNRNPD	CDK2	0.821047779	5.36E-31
UCS	Epifactor	HNRNPD	H1FX	0.821177745	5.15E-31
UCS	Epifactor	HNRNPD	ASF1B	0.821983215	4.03E-31
UCS	Epifactor	HNRNPD	HMGN2	0.825389361	1.41E-31
UCS	Epifactor	HNRNPD	CDK1	0.826247066	1.08E-31
UCS	Epifactor	HNRNPD	NASP	0.827033801	8.41E-32
UCS	Epifactor	HNRNPD	USP7	0.827639164	6.95E-32
UCS	Epifactor	HNRNPD	RAD51	0.828881174	4.68E-32
UCS	Epifactor	HNRNPD	TOP2A	0.830447075	2.83E-32
UCS	Epifactor	HNRNPD	RAD54L	0.830489302	2.80E-32
UCS	Epifactor	HNRNPD	H2AFV	0.832168103	1.62E-32
UCS	Epifactor	HNRNPD	UHRF1	0.83406575	8.70E-33
UCS	Epifactor	HNRNPD	HDAC1	0.834461359	7.64E-33
UCS	Epifactor	HNRNPD	BUB1	0.835908873	4.72E-33
UCS	Epifactor	HNRNPD	HDAC7	0.837947229	2.38E-33
UCS	Epifactor	HNRNPD	LBR	0.845648656	1.63E-34
UCS	Epifactor	HNRNPD	GFI1	0.846478048	1.21E-34
UCS	Epifactor	HNRNPD	MTF2	0.848552817	5.71E-35
UCS	Epifactor	HNRNPD	TAF5	0.852519837	1.32E-35
UCS	Epifactor	HNRNPD	HJURP	0.855445494	4.33E-36
UCS	Epifactor	HNRNPD	H2AFZ	0.858895518	1.13E-36
UCS	Epifactor	HNRNPD	TTK	0.859181122	1.01E-36
UCS	Epifactor	HNRNPD	MTA3	0.862233371	2.99E-37
UCS	Epifactor	HNRNPD	PCNA	0.873171969	2.93E-39
UCS	Epifactor	HNRNPD	CBX3	0.877027104	5.18E-40
UCS	Epifactor	HNRNPD	VRK1	0.898437861	1.03E-44
UCS	Epifactor	HNRNPD	SET	0.912218961	2.49E-48
UCS	Epifactor	HNRNPD	SFPQ	0.922406161	2.07E-51
UCS	Epifactor	HNRNPD	HMGB1	0.935160575	6.36E-56
UCS	IUPHAR	HNRNPD	KCNJ4	0.800534652	1.87E-28
UCS	IUPHAR	HNRNPD	PLK1	0.800998899	1.65E-28
UCS	IUPHAR	HNRNPD	CHEK1	0.803008453	9.58E-29
UCS	IUPHAR	HNRNPD	CCR9	0.804450988	6.46E-29
UCS	IUPHAR	HNRNPD	CYP2U1	0.805708606	4.56E-29
UCS	IUPHAR	HNRNPD	CAMK4	0.80599861	4.21E-29
UCS	IUPHAR	HNRNPD	EZH2	0.807070745	3.13E-29
UCS	IUPHAR	HNRNPD	HDAC2	0.811410504	9.17E-30
UCS	IUPHAR	HNRNPD	CD247	0.812083364	7.56E-30
UCS	IUPHAR	HNRNPD	LAIR1	0.813495474	5.03E-30
UCS	IUPHAR	HNRNPD	CHRNA3	0.814813501	3.43E-30
UCS	IUPHAR	HNRNPD	RRM2	0.815183505	3.08E-30
UCS	IUPHAR	HNRNPD	MELK	0.819220786	9.30E-31
UCS	IUPHAR	HNRNPD	PVRIG	0.819607327	8.28E-31
UCS	IUPHAR	HNRNPD	CDK2	0.821047779	5.36E-31
UCS	IUPHAR	HNRNPD	SLC23A1	0.822072681	3.92E-31
UCS	IUPHAR	HNRNPD	CDK6	0.824939837	1.62E-31
UCS	IUPHAR	HNRNPD	CDK1	0.826247066	1.08E-31
UCS	IUPHAR	HNRNPD	LCK	0.829929233	3.35E-32
UCS	IUPHAR	HNRNPD	TOP2A	0.830447075	2.83E-32
UCS	IUPHAR	HNRNPD	HDAC1	0.834461359	7.64E-33
UCS	IUPHAR	HNRNPD	BUB1	0.835908873	4.72E-33
UCS	IUPHAR	HNRNPD	KIF11	0.836796733	3.51E-33
UCS	IUPHAR	HNRNPD	HDAC7	0.837947229	2.38E-33
UCS	IUPHAR	HNRNPD	TUBB	0.84092105	8.59E-34
UCS	IUPHAR	HNRNPD	BUB1B	0.841046361	8.23E-34
UCS	IUPHAR	HNRNPD	RGS10	0.841302956	7.53E-34
UCS	IUPHAR	HNRNPD	PRKCQ	0.843455572	3.55E-34
UCS	IUPHAR	HNRNPD	TTK	0.859181122	1.01E-36
UCS	IUPHAR	HNRNPD	PDE7A	0.864754034	1.07E-37
UCS	IUPHAR	HNRNPD	PLK4	0.865224316	8.78E-38
UCS	IUPHAR	HNRNPD	PAFAH2	0.86878913	1.96E-38
UCS	IUPHAR	HNRNPD	ACAT2	0.87914866	1.95E-40
UCS	IUPHAR	HNRNPD	VRK1	0.898437861	1.03E-44
UCS	Kinase	HNRNPD	PLK1	0.800998899	1.65E-28
UCS	Kinase	HNRNPD	CHEK1	0.803008453	9.58E-29
UCS	Kinase	HNRNPD	CAMK4	0.80599861	4.21E-29
UCS	Kinase	HNRNPD	MELK	0.819220786	9.30E-31
UCS	Kinase	HNRNPD	CDK2	0.821047779	5.36E-31
UCS	Kinase	HNRNPD	CDK6	0.824939837	1.62E-31
UCS	Kinase	HNRNPD	CDK1	0.826247066	1.08E-31
UCS	Kinase	HNRNPD	LCK	0.829929233	3.35E-32
UCS	Kinase	HNRNPD	BUB1	0.835908873	4.72E-33
UCS	Kinase	HNRNPD	BUB1B	0.841046361	8.23E-34
UCS	Kinase	HNRNPD	PRKCQ	0.843455572	3.55E-34
UCS	Kinase	HNRNPD	TTK	0.859181122	1.01E-36
UCS	Kinase	HNRNPD	PLK4	0.865224316	8.78E-38
UCS	Kinase	HNRNPD	VRK1	0.898437861	1.03E-44
UCS	TF	HNRNPD	ZNF367	0.803588651	8.18E-29
UCS	TF	HNRNPD	FOXM1	0.804266193	6.79E-29
UCS	TF	HNRNPD	HINFP	0.80697832	3.21E-29
UCS	TF	HNRNPD	CTCF	0.807789929	2.56E-29
UCS	TF	HNRNPD	CBX2	0.811856669	8.07E-30
UCS	TF	HNRNPD	IKZF1	0.814570942	3.68E-30
UCS	TF	HNRNPD	MYB	0.816871322	1.87E-30
UCS	TF	HNRNPD	CENPA	0.81908043	9.70E-31
UCS	TF	HNRNPD	NFATC3	0.8239173	2.22E-31
UCS	TF	HNRNPD	TCF7	0.826082298	1.13E-31
UCS	TF	HNRNPD	E2F2	0.827704616	6.80E-32
UCS	TF	HNRNPD	E2F8	0.829057166	4.43E-32
UCS	TF	HNRNPD	LEF1	0.833636742	1.00E-32
UCS	TF	HNRNPD	GFI1	0.846478048	1.21E-34
UCS	TF	HNRNPD	MTF2	0.848552817	5.71E-35
UCS	TF	HNRNPD	TTF1	0.851568949	1.88E-35
UCS	TF	HNRNPD	TCF3	0.88698902	4.43E-42
UCS	TSG	HNRNPD	PLK1	0.800998899	1.65E-28
UCS	TSG	HNRNPD	PPP2CA	0.801542047	1.43E-28
UCS	TSG	HNRNPD	CHEK1	0.803008453	9.58E-29
UCS	TSG	HNRNPD	EZH2	0.807070745	3.13E-29
UCS	TSG	HNRNPD	CTCF	0.807789929	2.56E-29
UCS	TSG	HNRNPD	IKZF1	0.814570942	3.68E-30
UCS	TSG	HNRNPD	RBMX	0.818459726	1.17E-30
UCS	TSG	HNRNPD	CDK2	0.821047779	5.36E-31
UCS	TSG	HNRNPD	CDK6	0.824939837	1.62E-31
UCS	TSG	HNRNPD	E2F2	0.827704616	6.80E-32
UCS	TSG	HNRNPD	HDAC1	0.834461359	7.64E-33
UCS	TSG	HNRNPD	MUS81	0.842486906	4.99E-34
UCS	TSG	HNRNPD	DLEU2	0.850479139	2.82E-35
UCS	TSG	HNRNPD	TTF1	0.851568949	1.88E-35
UCS	TSG	HNRNPD	CHFR	0.860987747	4.93E-37
UCS	TSG	HNRNPD	BLM	0.873124225	2.99E-39
UCS	TSG	HNRNPD	TCF3	0.88698902	4.43E-42
UCS	TSG	HNRNPD	PTPN2	0.930341387	4.06E-54

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	HNRNPD	HNRNPU	-3.25414367586013	0.000109195709228516
LIHC	HNRNPD	PTBP1	-1.60687313741265	0.000235162875700189
KICH	HNRNPD	HNRNPU	1.45270865891102	0.000376403331756592
PRAD	HNRNPD	HNRNPU	-3.59255010200453	0.00074054058184854
ESCA	HNRNPD	HNRNPL	-1.16655433995144	0.0009765625
HNSC	HNRNPD	HNRNPC	-1.91657217726541	0.00135036232768471
KICH	HNRNPD	HNRNPF	1.50744544294582	0.00225526094436645
KICH	HNRNPD	PTBP1	-1.18983260644397	0.00250792503356934
LIHC	HNRNPD	HNRNPC	-1.08887561103821	0.00496795806084514
LIHC	HNRNPD	HNRNPF	-1.57993713616518	0.00511896143343789
COAD	HNRNPD	HNRNPH1	-2.11871535965424	0.00513318181037904
BRCA	HNRNPD	PCBP1	-1.00932820706241	0.00594051341818799
KICH	HNRNPD	EIF4G1	-1.46656081150743	0.00612920522689819
THCA	HNRNPD	HNRNPK	-8.73422542563389	0.00797530353045887
UCEC	HNRNPD	HNRNPC	1.18749806735276	0.03125
UCEC	HNRNPD	HNRNPK	1.64532744504864	0.03125
READ	HNRNPD	HNRNPF	1.32191790666862	0.03125
KIRP	HNRNPD	PTBP1	-2.97134811645458	1.49570405483246e-06
BRCA	HNRNPD	PTBP1	-3.14547372760314	1.65871323919358e-26
STAD	HNRNPD	HNRNPU	-1.26566952320815	2.26888805627823e-05
LIHC	HNRNPD	HNRNPU	-1.06098658215773	2.35319665208461e-06
HNSC	HNRNPD	PTBP1	2.31181500046206	2.41986685978191e-06
PRAD	HNRNPD	PTBP1	-1.65272232854382	2.91952404061616e-06
BRCA	HNRNPD	HNRNPL	-8.42108765925633	3.18828038788597e-25
LUAD	HNRNPD	PTBP1	-3.35409694114837	4.80565182905111e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with HNRNPD

LSM5, SAFB, TRN-GTT2-1, HSPB1, HSPA4, HSPA8, EIF4G1, HNRNPD, HNRNPH1, CDK9, MEPCE, KHDRBS2, GPN1, BANF1, tat, MTA2, HDAC1, PABPC1, H2AFX, CD4, HDAC5, Kif1c, Cep152, Shoc2, EBNA-LP, HSPB2, MAPK6, PCBP1, PCBP2, VHL, SMARCAD1, SREK1, ARRB2, HNRNPA1, PAIP1, BCL2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, SYNCRIP, YBX1, IGF2BP2, UBE2I, MEOX2, GRB2, VEGFA, TNF, HNRNPR, PTBP1, RBMX, HNRNPF, HNRNPL, HNRNPA2B1, HNRNPA0, HNRNPA3, MRPL12, RPS28, RALY, HNRNPDL, AHNAK, RMDN3, SEPT9, SLC30A5, DDX1, MSH2, SMURF1, SFN, FN1, VCAM1, SNRPC, SF3B4, U2AF2, HNRNPC, HNRNPU, HNRNPK, HNRNPH3, PTBP2, IFIT2, IFIT3, IL7R, BRCA1, ITGA4, PAN2, CD81, IGSF8, ICAM1, HMGA1, C1QBP, RPSA, ACTB, GTF3C3, CD97, EXOSC4, EEF2, SNAPC4, ABCC10, BET1L, TSEN34, CINP, SHISA5, MPP1, TMEM261, GUK1, P4HB, FLNA, ARF4, SLC3A2, MAP2K1, HIRA, DGCR2, CAPN1, HBZ, PDLIM7, IMMT, PYCR1, SLC27A5, NTMT1, DHX30, CUTA, GTSE1, FBXL15, COL18A1, IMMP2L, COG7, PPOX, CTSB, PEX10, UQCRC1, PRDX3, SDF2, B3GAT3, PARK2, EIF3K, DENR, IPO11, ERI1, PAFAH1B3, KHSRP, RPS12, WNK1, rev, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, IVNS1ABP, STAU1, NCL, KAT2B, FUS, ING4, MYC, ENO1, MOV10, NXF1, MDM2, CUL7, OBSL1, EED, ESR1, BTRC, FBXW11, PTGS2, CHEK1, DNAJC7, HNRNPAB, AURKA, C2orf49, HSPA9, NAA50, PICALM, PKM, SFPQ, TARS, TOMM34, UBE2G2, PGK1, NTRK1, SCARNA22, EWSR1, BLMH, SLC25A20, CETN2, DKC1, DNM2, ETFA, FANCD2, ACSL4, MTOR, GOLGA4, HEXA, DYNC1H1, HNRNPH2, MYEF2, HSD17B4, HSPA6, ITGB4, EIF6, MAP3K4, MYH1, NHS, PDCL, PLXNB1, PPM1A, RBM4, RET, SRSF6, UAP1, TARBP1, GCFC2, TLN1, TNFRSF1A, BAG6, USP11, DYSF, NRP1, TAX1BP1, FUBP3, GTF2IRD1, ESPL1, ARHGAP32, C2CD5, OSBPL2, RBM8A, PRMT3, SAP18, ABCA7, TUBB3, PPIH, SRSF10, COG2, FNDC3A, MORC2, FAM120A, USP24, KIAA0368, DICER1, SIRT5, KLHDC2, INTS7, PKN3, PNPLA8, CHMP5, UHRF1BP1, RASIP1, PINX1, HEATR3, SMEK2, ZNF286A, GPBP1, PDRG1, SBF2, TLN2, KLF16, OBSCN, WDR24, GPRIN1, MRPL55, PTGR2, PPP1R18, DDX51, HNRNPCL1, MCM2, SNW1, NPM1, CYLD, TRIM25, UBE2A, HEY1, TARDBP, TRIM14, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, RNF4, RIOK1, FGF11, HEXIM1, LARP7, SNAI1, AGR2, RECQL4, STUB1, GPC1, REST, TRAPPC2L, CTBP1, IGF2BP1, TRAPPC13, RAB1A, MTF2, GCNT2, MOGS, B4GALT1, TRAPPC12, MAN1A1, CBL, MAN1B1, TRAPPC11, ARL5A, FUT8, RICTOR, DEPDC5, SEC31A, DAZAP1, TCF3, HSP90AB1, NCOR1, RABGEF1, RAB1B, VPS45, CARM1, UBE2M, SAR1A, TBL1XR1, SEC24C, WDR76, HIST1H4A, HIST1H2BB, HIST1H2AB, TP53BP1, METTL3, METTL14, EIF4B, RC3H1, RC3H2, ATG16L1, ACTC1, PHB, RBX1, MAPT, USP14, NR2C2, UCHL3, VRK1, HADHB, MTX1, TOMM40, VDAC2, TOMM22, TOMM5, VDAC3, MAB21L2, SNRNP70, TET1, Dppa3, MATR3, ITFG1, ARAF, BIRC3, NFX1, WWP2, BRD7, UBC, TP53, TRIM28, ARIH2, PLEKHA4, HNRNPM, EIF4E2, POLR2A, POLR2B, MED12, MED14, MED15, MED16, MED17, MED24, MED4, AGO1, AGO2, AGO3, ELAVL1, LARP1, HIST1H1A, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H1B, H1FX, HIST1H2AG, HIST1H2AA, HIST1H2AE, HIST1H2AC, HIST1H2AD, HIST1H2AH, HIST1H2AJ, HIST2H2AA3, HIST2H2AB, HIST2H2AC, HIST3H2A, H2AFJ, HIST1H2BC, HIST1H2BD, HIST1H2BH, HIST1H2BK, HIST1H2BL, HIST1H2BN, LRP8, LOC102724334, ZC3HAV1, ZCCHC8, ZMIZ1, ZNF207, DPF2, SMARCC1, SMARCC2, SMARCB1, SMARCD2, SMARCE1, XRCC5, XRCC6, PARP1, YWHAZ, CDK8, CCNC, TP63, G3BP1, G3BP2, GNB2L1, PPP1CA, PPP1CB, S100A9, PINK1, YAP1, TFCP2, NGB, HCVgp1, ORF50, ZC3H18, B4GAT1, MAP1B, ACTR2, ATP7A, EML5, NFE2L2, HNRNPA1L2, SMC6, HECW2, GPATCH8, ATRX, ALS2CR11, ANKRD20A12P, PDLIM1, ANKRD12, SPATA31E1, DNAH3, NCOA3, JAK1, OR2AJ1, RAP1A, HEBP2, CELF1, NEK4, CIT, ANLN, ECT2, KIF14, KIF20A, PRC1, GRSF1, METTL17, SSBP1, INS, NDN, BRD4, NINL, RBM45, Apc2, RBM39, FBP1, MKRN1, LGALS9, IFI16, N, vpr, RIN3, UCP3, OGT, SPOP, UFL1, DDRGK1, COIL, TRIM37, LINC01232, FZR1, WDR5, NUDCD2, EP300, RCHY1, CCNF, NR3C1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
HNRNPD	chr4	83276386	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
HNRNPD	chr4	83276430	C	CA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
HNRNPD	chr4	83278580	G	GAGCT	Duplication	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
HNRNPD	chr4	83278778	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
HNRNPD	chr4	83278915	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
HNRNPD	chr4	83279722	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
HNRNPD	chr4	83279731	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
HNRNPD	chr4	83293033	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
HNRNPD	chr4	83295218	G	GT	Duplication	Benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
HNRNPD	LUAD	chr4	83278025	83278025	C	-	Frame_Shift_Del	p.S259fs	4
HNRNPD	READ	chr4	83279884	83279884	T	G	Missense_Mutation	p.K183N	4
HNRNPD	HNSC	chr4	83280734	83280735	-	C	Frame_Shift_Ins	p.Y116fs	3
HNRNPD	LUAD	chr4	83279893	83279893	C	A	Silent	p.P180P	3
HNRNPD	UCS	chr4	83280639	83280639	C	T	Silent	p.S148S	3
HNRNPD	BRCA	chr4	83277695	83277695	T	C	Missense_Mutation	p.Y332C	3
HNRNPD	ESCA	chr4	83279935	83279935	C	T	Silent	p.V166V	3
HNRNPD	PRAD	chr4	83280638	83280638	C	A	Nonsense_Mutation	p.E149*	3
HNRNPD	UCEC	chr4	83278594	83278594	C	T	Missense_Mutation	p.E209K	2
HNRNPD	HNSC	chr4	83280732	83280732	A	T	Missense_Mutation	p.F117L	2
HNRNPD	ESCA	chr4	83278549	83278549	C	T	Missense_Mutation		2
HNRNPD	SARC	chr4	83278573	83278573	C	G	Missense_Mutation		2
HNRNPD	BRCA	chr4	83278494	83278495	TT	-	Frame_Shift_Del	p.K242fs	2
HNRNPD	ESCA	chr4	83292697	83292697	C	T	Missense_Mutation		2
HNRNPD	SARC	chr4	83280730	83280730	G	A	Missense_Mutation		2
HNRNPD	SARC	chr4	83278573	83278573	C	G	Missense_Mutation	p.D216H	2
HNRNPD	ESCA	chr4	83278549	83278549	C	T	Missense_Mutation	p.G224R	2
HNRNPD	SARC	chr4	83280730	83280730	G	A	Missense_Mutation	p.S118F	2
HNRNPD	SKCM	chr4	83277705	83277705	A	G	Missense_Mutation	p.Y329H	2
HNRNPD	UCEC	chr4	83277987	83277987	C	T	Missense_Mutation	p.R272K	2
HNRNPD	UCEC	chr4	83278008	83278013	TGCTGA	-	In_Frame_Del	p.YQQQQQ263in_frame_del*	2
HNRNPD	LIHC	chr4	83276496	83276496	T	-	Frame_Shift_Del	p.K353fs	2
HNRNPD	HNSC	chr4	83279810	83279810	A	G	Splice_Site		2
HNRNPD	BLCA	chr4	83280703	83280703	G	A	Missense_Mutation	p.T127I	2
HNRNPD	LGG	chr4	83279883	83279883	T	-	Frame_Shift_Del	p.I184fs	2
HNRNPD	UCEC	chr4	83278493	83278493	C	A	Nonsense_Mutation	p.E146*	2
HNRNPD	LIHC	chr4	83276540	83276540	A	-	Frame_Shift_Del	p.Y339fs	2
HNRNPD	HNSC	chr4	83280732	83280732	A	T	Missense_Mutation		2
HNRNPD	UCEC	chr4	83278508	83278508	C	A	Nonsense_Mutation	p.E141*	2
HNRNPD	LIHC	chr4	83277993	83277993	C	-	Frame_Shift_Del	p.G270fs	2
HNRNPD	HNSC	chr4	83279847	83279847	C	G	Missense_Mutation	p.E196Q	1
HNRNPD	STAD	chr4	83278030	83278030	T	C	Missense_Mutation	p.M258V	1
HNRNPD	BLCA	chr4	83280673	83280673	G	C	Nonsense_Mutation	p.S137*	1
HNRNPD	LIHC	chr4	83278019	83278020	-	-	Frame_Shift_Ins		1
HNRNPD	ESCA	chr4	83279935	83279935	C	T	Silent		1
HNRNPD	LIHC	chr4	83278553	83278553	C	-	Frame_Shift_Del	p.R223fs	1
HNRNPD	SARC	chr4	83279912	83279912	G	T	Missense_Mutation		1
HNRNPD	STAD	chr4	83276455	83276455	A	G	Splice_Site		1
HNRNPD	BLCA	chr4	83277772	83277773	-	C	Frame_Shift_Ins	p.G306fs	1
HNRNPD	LIHC	chr4	83278548	83278548	C	A	Missense_Mutation		1
HNRNPD	UCS	chr4	83279884	83279884	T	A	Missense_Mutation		1
HNRNPD	LIHC	chr4	83279914	83279914	T	-	Frame_Shift_Del	p.K173fs	1
HNRNPD	ACC	chr4	83277966	83277966	G	T	Missense_Mutation	p.A279D	1
HNRNPD	THCA	chr4	83280727	83280727	T	C	Missense_Mutation		1
HNRNPD	UCS	chr4	83280639	83280639	C	T	Silent		1
HNRNPD	LIHC	chr4	83277759	83277759	C	A	Missense_Mutation		1
HNRNPD	ACC	chr4	83294784	83294784	C	T	Silent	p.T16T	1
HNRNPD	KIRC	chr4	83280713	83280713	C	T	Missense_Mutation	p.V124I	1
HNRNPD	THCA	chr4	83280727	83280727	T	C	Missense_Mutation	p.K119R	1
HNRNPD	LIHC	chr4	83278019	83278020	-	C	Frame_Shift_Ins	p.E261fs	1
HNRNPD	LUAD	chr4	83276523	83276523	C	A	Missense_Mutation	p.R344S	1
HNRNPD	BLCA	chr4	83278012	83278012	G	C	Missense_Mutation		1
HNRNPD	KIRP	chr4	83279841	83279841	T	C	Missense_Mutation	p.I198V	1
HNRNPD	UCEC	chr4	83277757	83277757	A	C	Silent	p.G311G	1
HNRNPD	COAD	chr4	83277754	83277754	G	A	Silent	p.Y312Y	1
HNRNPD	LIHC	chr4	83280683	83280683	T	C	Missense_Mutation	p.T134A	1
HNRNPD	BLCA	chr4	83280703	83280703	G	A	Missense_Mutation		1
HNRNPD	LGG	chr4	83277817	83277817	G	A	Silent	p.N291N	1
HNRNPD	UCEC	chr4	83294711	83294711	C	-	Frame_Shift_Del	p.A41fs	1
HNRNPD	COAD	chr4	83277964	83277964	G	A	Missense_Mutation	p.R280C	1
HNRNPD	LIHC	chr4	83294718	83294718	C	T	Silent	p.A38A	1
HNRNPD	ESCA	chr4	83278541	83278541	G	T	Nonsense_Mutation	p.C226X	1
HNRNPD	LUSC	chr4	83278594	83278594	C	A	Nonsense_Mutation	p.E209*	1
HNRNPD	SARC	chr4	83279912	83279912	G	T	Missense_Mutation	p.A174D	1
HNRNPD	BLCA	chr4	83278511	83278511	C	T	Silent		1
HNRNPD	LGG	chr4	83280668	83280668	C	T	Missense_Mutation	p.G139S	1
HNRNPD	UCEC	chr4	83278008	83278013	TGCTGA	-	In_Frame_Del	p.263_265YQQ>*	1
HNRNPD	LIHC	chr4	83279826	83279827	-	A	Frame_Shift_Ins	p.LW202fs	1
HNRNPD	COAD	chr4	83278485	83278485	T	C	Missense_Mutation	p.H245R	1
HNRNPD	HNSC	chr4	83279847	83279847	C	G	Missense_Mutation		1
HNRNPD	OV	chr4	83497070	83497070	A	G	Silent	p.C252	1
HNRNPD	BLCA	chr4	83277772	83277773	-	-	Frame_Shift_Ins		1
HNRNPD	LGG	chr4	83277715	83277715	G	A	Silent	p.N325N	1
HNRNPD	DLBC	chr4	83294683	83294683	C	T	Missense_Mutation	p.G50E	1
HNRNPD	LIHC	chr4	83278019	83278020	-	C	Frame_Shift_Ins	p.A261fs	1
HNRNPD	HNSC	chr4	83280734	83280735	-	-	Frame_Shift_Ins		1
HNRNPD	PRAD	chr4	83280638	83280638	C	A	Nonsense_Mutation	p.E149X	1
HNRNPD	SKCM	chr4	83278026	83278026	G	A	Missense_Mutation	p.S259L	1
HNRNPD	BLCA	chr4	83278012	83278012	G	C	Missense_Mutation	p.Q264E	1
HNRNPD	LGG	chr4	83279852	83279852	G	T	Missense_Mutation	p.P194H	1
HNRNPD	DLBC	chr4	83294756	83294756	G	A	Nonsense_Mutation	p.Q26X	1
HNRNPD	SKCM	chr4	83278003	83278003	G	C	Missense_Mutation	p.Q267E	1
HNRNPD	ESCA	chr4	83276431	83276431	A	-	RNA	NULL	1
HNRNPD	STAD	chr4	83278029	83278029	A	G	Missense_Mutation	p.M258T	1
HNRNPD	BLCA	chr4	83278511	83278511	C	T	Silent	p.V236V	1
HNRNPD	LGG	chr4	83279883	83279883	T	G	Missense_Mutation		1
HNRNPD	ESCA	chr4	83292697	83292697	C	T	Missense_Mutation	p.A92T	1

Copy number variation (CNV) of HNRNPD
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across HNRNPD
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102336	N/A	GW492815	ACBD3	chr1	226351511	-	HNRNPD	chr4	83274982	+
102336	Non-Cancer	ERR315469	BPI	chr20	36940339	+	HNRNPD	chr4	83292737	-
102336	Non-Cancer	TCGA-BH-A0E0-11A	DMD	chrX	32305646	-	HNRNPD	chr4	83280792	-
80213	N/A	BP428682	HNRNPD	chr4	83280709	-	AQR	chr15	35181022	-
79791	PRAD	TCGA-HC-7820-01A	HNRNPD	chr4	83292681	-	C4orf22	chr4	81865964	+
102782	N/A	DB050538	HNRNPD	chr4	83295053	-	ELL	chr19	18555299	-
93318	N/A	FN064911	HNRNPD	chr4	83274700	+	FHOD3	chr18	33901514	-
102336	N/A	BE935692	HNRNPD	chr4	83292153	+	HNRNPD	chr4	83284211	-
88015	N/A	BM835099	HNRNPD	chr4	83294848	-	NOL6	chr9	33466171	-
102244	N/A	AW022170	HNRNPD	chr4	83274982	-	PARP11	chr12	3909085	+
60130	MESO	TCGA-TS-A8AF-01A	HNRNPD	chr4	83292681	-	PRKG2	chr4	82031765	-
77465	N/A	BF525535	HNRNPD	chr4	83275140	-	RND1	chr12	49254366	-
91718	CESC	TCGA-ZJ-A8QO-01A	HNRNPD	chr4	83294599	-	SCD5	chr4	83626566	-
91809	N/A	AV696659	HNRNPD	chr4	83274989	-	SLC22A10	chr11	63124495	+
70845	N/A	BG988244	HNRNPD	chr4	83275470	+	TMEM67	chr8	94828925	+
97855	N/A	BE646088	HNRNPD	chr4	83275258	+	VAMP2	chr17	8063452	+
102336	BRCA	TCGA-E9-A1ND	KIAA0232	chr4	6843931	+	HNRNPD	chr4	83280792	-
102336	N/A	AA010774	LAMB2	chr3	49162488	-	HNRNPD	chr4	83275343	-
102336	GBM	TCGA-27-2526-01A	MKLN1	chr7	130827700	+	HNRNPD	chr4	83280792	-
102336	N/A	BF096106	NFE2L2	chr2	178096309	-	HNRNPD	chr4	83275272	+
102336	N/A	BI492297	PARP11	chr12	3909085	-	HNRNPD	chr4	83274982	+
102336	N/A	AA480614	PASD1	chrX	150834868	+	HNRNPD	chr4	83274982	+
102336	N/A	BF096098	PDCD10	chr3	167446632	+	HNRNPD	chr4	83277976	-
102336	Non-Cancer	2397N	PLAC8	chr4	84035818	-	HNRNPD	chr4	83279973	-
102336	N/A	BF805251	PPDPF	chr20	62152884	-	HNRNPD	chr4	83278003	+
102336	N/A	DA845763	RASGRF1	chr15	79296310	-	HNRNPD	chr4	83295087	-
102336	N/A	DA569517	RILPL2	chr12	123907633	-	HNRNPD	chr4	83294626	-
102336	PRAD	TCGA-J4-A67M	WDFY3	chr4	85800559	-	HNRNPD	chr4	83276554	-
102336	PRAD	TCGA-J4-A67M	WDFY3	chr4	85818063	-	HNRNPD	chr4	83276554	-
102336	PRAD	TCGA-J4-A67M	WDFY3	chr4	85818064	-	HNRNPD	chr4	83276554	-
102336	CESC	TCGA-C5-A1BM-01A	YWHAZ	chr8	101960824	-	HNRNPD	chr4	83275307	-
102336	STAD	TCGA-CD-A486-01A	ZNF33B	chr10	43133922	-	HNRNPD	chr4	83280792	-
102339	UCS	TCGA-N8-A4PP-01A	ZNF546	chr19	40514472	+	HNRNPD	chr4	83280792	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LAML	HNRNPD	0.0356216499787857	1
BRCA	HNRNPD	0.000139899117814633	0.0046
PAAD	HNRNPD	0.0217807902715892	0.65
ESCA	HNRNPD	0.00275537099748613	0.085
THYM	HNRNPD	0.00056060090985672	0.018

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source