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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: NANOS3 (NCBI Gene ID:342977)

Gene Summary

Gene Summary

Gene Information	Gene Name: NANOS3
	Gene ID: 342977
	Gene Symbol	NANOS3
	Gene ID	342977
	Gene Name	nanos C2HC-type zinc finger 3
	Synonyms	NANOS1L\|NOS3\|ZC2HC12C
	Cytomap	19p13.12
	Type of Gene	protein-coding
	Description	nanos homolog 3
	Modification date	20200313
	UniProtAcc	P60323

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NANOS3	GO:0017148	negative regulation of translation	24736845
Hgene	NANOS3	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	24736845

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
NANOS3	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'NANOS3[title] AND translation [title] AND human.'

Gene	Title	PMID
NANOS3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	NANOS3	-3.55083213833258	0.00390625
KICH	NANOS3	1.8074576054954	2.5629997253418e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	NANOS3	0.020082773	0.00027435

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with NANOS3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
TGCT	Cell metabolism gene	NANOS3	GCAT	0.810525974	1.32E-37
TGCT	Cell metabolism gene	NANOS3	AWAT2	0.819696586	4.21E-39
TGCT	Cell metabolism gene	NANOS3	MUC21	0.830111138	6.62E-41
TGCT	Cell metabolism gene	NANOS3	AGPAT6	0.839754811	1.09E-42
TGCT	Cell metabolism gene	NANOS3	GIP	0.852857112	2.60E-45
TGCT	Cell metabolism gene	NANOS3	GMPR	0.85448947	1.18E-45
TGCT	Cell metabolism gene	NANOS3	ELOVL3	0.907794101	5.45E-60
TGCT	CGC	NANOS3	PRDM1	0.800804038	4.15E-36
TGCT	CGC	NANOS3	ELL	0.869391538	5.22E-49
TGCT	CGC	NANOS3	TCL1A	0.883647016	1.26E-52
TGCT	Epifactor	NANOS3	PRDM1	0.800804038	4.15E-36
TGCT	Epifactor	NANOS3	BMI1	0.806146908	6.38E-37
TGCT	Epifactor	NANOS3	GATAD2A	0.818701809	6.18E-39
TGCT	IUPHAR	NANOS3	IFI16	0.808904677	2.37E-37
TGCT	IUPHAR	NANOS3	TRPC5	0.813159223	5.00E-38
TGCT	IUPHAR	NANOS3	KCNK13	0.819329219	4.86E-39
TGCT	IUPHAR	NANOS3	ABCC12	0.833318633	1.74E-41
TGCT	IUPHAR	NANOS3	NLRP9	0.839383838	1.28E-42
TGCT	IUPHAR	NANOS3	KCNA2	0.856058269	5.44E-46
TGCT	IUPHAR	NANOS3	AQP6	0.859830677	8.20E-47
TGCT	IUPHAR	NANOS3	HCN4	0.865226197	4.96E-48
TGCT	IUPHAR	NANOS3	SLC5A7	0.906634605	1.36E-59
TGCT	IUPHAR	NANOS3	SLC43A1	0.934148695	8.43E-71
TGCT	TF	NANOS3	PRDM1	0.800804038	4.15E-36
TGCT	TF	NANOS3	ZNF341	0.801444358	3.33E-36
TGCT	TF	NANOS3	ZNF571	0.803222626	1.79E-36
TGCT	TF	NANOS3	ZNF781	0.803324799	1.73E-36
TGCT	TF	NANOS3	ZNF569	0.815788824	1.87E-38
TGCT	TF	NANOS3	ZNF428	0.816174417	1.62E-38
TGCT	TF	NANOS3	ZNF610	0.81726711	1.07E-38
TGCT	TF	NANOS3	ZNF14	0.8183058	7.19E-39
TGCT	TF	NANOS3	GATAD2A	0.818701809	6.18E-39
TGCT	TF	NANOS3	ZNF547	0.820446854	3.15E-39
TGCT	TF	NANOS3	THAP8	0.834206751	1.19E-41
TGCT	TF	NANOS3	ZNF526	0.853892401	1.58E-45
TGCT	TF	NANOS3	ZNF766	0.858184371	1.89E-46
TGCT	TF	NANOS3	DMRT1	0.878799764	2.41E-51
TGCT	TF	NANOS3	BNC1	0.887388482	1.18E-53
TGCT	TSG	NANOS3	PRDM1	0.800804038	4.15E-36
TGCT	TSG	NANOS3	IFI16	0.808904677	2.37E-37
TGCT	TSG	NANOS3	CDK2AP1	0.809837952	1.69E-37
TGCT	TSG	NANOS3	LZTS1	0.814148117	3.46E-38
TGCT	TSG	NANOS3	CSMD1	0.84728527	3.63E-44

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	NANOS3	TDRD7	-5.32549817757915	0.00100010249745768
BRCA	NANOS3	DAZL	-2.20715286337894	0.00225146058865309
LIHC	NANOS3	DND1	-3.89179043999306	0.0033398145023608
LIHC	NANOS3	DDX4	-1.38709810298453	0.00693140429335888
THCA	NANOS3	PUM1	-1.96241697156045	0.0106190889115253
LUAD	NANOS3	STRA8	-1.41754146083021	0.0167287003897047
LIHC	NANOS3	STRA8	-3.87887257303094	0.0170556294065931
THCA	NANOS3	DAZL	1.75658759829506	0.0178581180286603
KIRP	NANOS3	DND1	-2.49943289242313	0.0279771662317216
COAD	NANOS3	DND1	-1.48588602291338	0.0291509032249451
LUSC	NANOS3	DDX4	-1.95443502746625	0.0421700405387188
THCA	NANOS3	PIWIL1	1.03261884319603	1.02220761620756e-06
COAD	NANOS3	TDRD7	-1.15983938529281	1.33216381072998e-05
BRCA	NANOS3	DND1	-1.16039496976923	1.73769696617764e-07
THCA	NANOS3	PUM2	-1.39880758764172	1.87410187143234e-06
THCA	NANOS3	PRDM1	1.56256807667019	2.20724500943986e-09
KIRC	NANOS3	PRDM14	-3.53697173732648	3.60241778081952e-05
LUAD	NANOS3	DND1	-2.01712494132399	4.57458841817018e-05
THCA	NANOS3	DND1	-1.6376184969496	4.60078709441939e-09
KIRC	NANOS3	PUM1	-2.76249172813289	5.12753234766593e-06
PRAD	NANOS3	TDRD7	1.20035553038449	8.50750576591638e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with NANOS3

PUM2, CNOT1, CNOT3, DMRT1, SIAH1, PSMB1, MLH1, CIB3, TEKT4, IMP3, CIT, AURKB, CHMP4B, KIF14, KIF20A, PRC1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
NANOS3	chr19	13988181	T	TGGAGCCGGTGTCAGCGCC	Insertion	Benign	not_provided	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
NANOS3	chr19	13988558	C	CGAG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001821\|inframe_insertion	SO:0001619\|non-coding_transcript_variant,SO:0001821\|inframe_insertion

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
NANOS3	HNSC	chr19	13988559	13988561	GAG	-	In_Frame_Del	p.RG147del	5
NANOS3	SKCM	chr19	13988138	13988138	C	T	Missense_Mutation	p.P26S	3
NANOS3	BLCA	chr19	13991286	13991286	C	T	Missense_Mutation		2
NANOS3	PAAD	chr19	13988311	13988311	C	T	Silent		2
NANOS3	UCEC	chr19	13988256	13988256	G	A	Missense_Mutation	p.R65H	2
NANOS3	LIHC	chr19	13988465	13988465	T	A	Missense_Mutation		2
NANOS3	UCEC	chr19	13988362	13988362	C	T	Silent	p.G100	2
NANOS3	PAAD	chr19	13988311	13988311	C	T	Silent	p.N64N	2
NANOS3	ESCA	chr19	13988559	13988559	G	T	Missense_Mutation	p.R166L	2
NANOS3	BLCA	chr19	13991286	13991286	C	T	Missense_Mutation	p.S164L	2
NANOS3	SKCM	chr19	13988108	13988108	C	T	Silent	p.L16L	2
NANOS3	SKCM	chr19	13988354	13988354	G	A	Missense_Mutation	p.E79K	2
NANOS3	STAD	chr19	13988423	13988423	C	T	Missense_Mutation	p.R121C	2
NANOS3	KIRP	chr19	13988558	13988559	-	GAG	In_Frame_Ins	p.146_147insE	2
NANOS3	STAD	chr19	13988417	13988417	C	T	Missense_Mutation	p.R119C	2
NANOS3	KIRP	chr19	13988494	13988494	A	G	Silent	p.R144R	2
NANOS3	STAD	chr19	13988458	13988458	C	T	Silent	p.G132G	2
NANOS3	BRCA	chr19	13988416	13988416	A	G	Silent	p.T118	1
NANOS3	SKCM	chr19	13988377	13988377	C	T	Silent	p.P86P	1
NANOS3	KIRP	chr19	13988558	13988559	-	GAG	In_Frame_Ins	p.171_172insG	1
NANOS3	THCA	chr19	13991282	13991282	C	T	Missense_Mutation	p.P163S	1
NANOS3	COAD	chr19	13988181	13988182	-	GGAGCCGGTGTCAGCGCC	In_Frame_Ins	p.L40delinsLEPVSAP	1
NANOS3	SKCM	chr19	13988141	13988141	G	A	Missense_Mutation	p.E27K	1
NANOS3	KIRP	chr19	13988364	13988364	G	T	Missense_Mutation		1
NANOS3	PAAD	chr19	13988311	13988311	C	T	Silent	p.N83N	1
NANOS3	BLCA	chr19	13988525	13988525	G	A	Missense_Mutation	p.D136N	1
NANOS3	COAD	chr19	13988322	13988322	G	T	Missense_Mutation	p.R87L	1
NANOS3	SKCM	chr19	13988320	13988320	C	T	Silent	p.S67S	1
NANOS3	BLCA	chr19	13988426	13988426	G	A	Missense_Mutation	p.A103T	1
NANOS3	COAD	chr19	13988558	13988559	-	GAGGAG	In_Frame_Ins	p.R166delinsRGG	1
NANOS3	SKCM	chr19	13988295	13988295	C	T	Missense_Mutation	p.S59F	1
NANOS3	LIHC	chr19	13988407	13988407	C	T	Silent	p.C115C	1
NANOS3	BLCA	chr19	13988556	13988556	G	T	Missense_Mutation	p.R146L	1
NANOS3	SARC	chr19	13991267	13991267	G	T	Missense_Mutation		1
NANOS3	SKCM	chr19	13988435	13988435	C	T	Nonsense_Mutation	p.R106*	1
NANOS3	LIHC	chr19	13988465	13988465	T	A	Missense_Mutation	p.Y135N	1
NANOS3	BLCA	chr19	13988397	13988397	G	A	Missense_Mutation	p.C93Y	1
NANOS3	SKCM	chr19	13988290	13988290	G	T	Silent	p.L76L	1
NANOS3	SKCM	chr19	13988159	13988159	C	A	Missense_Mutation	p.Q33K	1
NANOS3	LIHC	chr19	13988410	13988410	C	A	Silent	p.G116G	1
NANOS3	BLCA	chr19	13988429	13988429	C	T	Missense_Mutation	p.H104Y	1
NANOS3	SKCM	chr19	13988320	13988320	C	T	Silent	p.S86S	1
NANOS3	HNSC	chr19	13991286	13991286	C	T	Missense_Mutation	p.S183L	1
NANOS3	SKCM	chr19	13988290	13988290	G	T	Silent	p.L57L	1
NANOS3	LIHC	chr19	13988465	13988465	T	A	Missense_Mutation	p.Y116N	1
NANOS3	HNSC	chr19	13988559	13988561	GAG	-	In_Frame_Del	p.G171del	1
NANOS3	LUAD	chr19	13991269	13991269	C	T	Silent	p.A158A	1
NANOS3	BLCA	chr19	13988556	13988556	G	T	Missense_Mutation	p.R165L	1
NANOS3	KIRP	chr19	13988494	13988494	A	G	Silent	p.R125R	1
NANOS3	LUAD	chr19	13988558	13988558	C	T	Nonsense_Mutation	p.R147*	1
NANOS3	BLCA	chr19	13988397	13988397	G	A	Missense_Mutation	p.C112Y	1
NANOS3	SKCM	chr19	13988354	13988354	G	A	Missense_Mutation	p.E98K	1
NANOS3	BLCA	chr19	13988556	13988556	G	T	Missense_Mutation		1
NANOS3	LUSC	chr19	13985806	13985806	G	T	RNA		1
NANOS3	BLCA	chr19	13988429	13988429	C	T	Missense_Mutation	p.H123Y	1
NANOS3	SKCM	chr19	13988132	13988132	G	A	Missense_Mutation	p.E24K	1
NANOS3	BLCA	chr19	13988397	13988397	G	A	Missense_Mutation		1
NANOS3	LUSC	chr19	13988533	13988533	G	A	Silent	p.A157A	1

Copy number variation (CNV) of NANOS3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across NANOS3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
69616	STAD	TCGA-BR-8058-01A	NANOS3	chr19	13973008	+	SAMD1	chr19	14200174	-
103106	THYM	TCGA-XU-A92V-01A	SBNO2	chr19	1147308	-	NANOS3	chr19	13991256	+
103106	BLCA	TCGA-FD-A3SR-01A	ZNF254	chr19	24229081	+	NANOS3	chr19	13991256	+
103106	SKCM	TCGA-DA-A1I0-06A	ZNF57	chr19	2901046	+	NANOS3	chr19	13991256	+
103109	LGG	TCGA-S9-A7IZ-01A	ZNF91	chr19	23578127	-	NANOS3	chr19	13991256	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
MESO	NANOS3	0.00897369329233724	0.25
TGCT	NANOS3	0.0121376998711203	0.33
HNSC	NANOS3	0.0205438429569787	0.53
BLCA	NANOS3	0.024802693666011	0.62
LUSC	NANOS3	0.0364793012180875	0.88

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	NANOS3	0.00465489392443551	0.15
BRCA	NANOS3	0.00742047800277233	0.23
CESC	NANOS3	0.000310981290427067	0.01
PCPG	NANOS3	0.0268128183462912	0.8
THYM	NANOS3	0.0403341594774081	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0085215	Ovarian Failure, Premature	1	GENOMICS_ENGLAND