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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: BARHL2 (NCBI Gene ID:343472)

Gene Summary

Gene Summary

Gene Information	Gene Name: BARHL2
	Gene ID: 343472
	Gene Symbol	BARHL2
	Gene ID	343472
	Gene Name	BarH like homeobox 2
	Synonyms	-
	Cytomap	1p22.2
	Type of Gene	protein-coding
	Description	barH-like 2 homeobox protein
	Modification date	20200313
	UniProtAcc	Q9NY43

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
BARHL2	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'BARHL2[title] AND translation [title] AND human.'

Gene	Title	PMID
BARHL2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	BARHL2	-1.51747120975505	0.0440109840129515

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
BRCA	BARHL2	hsa-miR-130b-3p	95	0.327192347978254	0.00324767959248961

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
TGCT	BARHL2	2	1	0.0282069317596942	0.256594920634921	0.153674074074074	1.03422397971047	0.752830963837686

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
DLBC	BARHL2	-0.068596077	0.032412728

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with BARHL2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	BARHL2	GPX5	0.838452683	6.60E-13
CHOL	Cell metabolism gene	BARHL2	TSHB	0.971138441	2.13E-28
CHOL	IUPHAR	BARHL2	GABRR3	0.901635899	2.97E-17
CHOL	TF	BARHL2	NKX2-4	0.901635899	2.97E-17
DLBC	CGC	BARHL2	TLX3	0.943394087	1.11E-23
DLBC	IUPHAR	BARHL2	GPR6	0.850013834	2.14E-14
DLBC	IUPHAR	BARHL2	NTSR2	0.85308249	1.37E-14
DLBC	IUPHAR	BARHL2	ADAM7	0.863359258	2.91E-15
DLBC	IUPHAR	BARHL2	GABRA6	0.88817718	3.82E-17
DLBC	TF	BARHL2	DMRTC2	0.809958191	3.13E-12
DLBC	TF	BARHL2	BARHL1	0.848123768	2.79E-14
DLBC	TF	BARHL2	TLX3	0.943394087	1.11E-23
LAML	Cell metabolism gene	BARHL2	GSTA2	1	0
LAML	IUPHAR	BARHL2	MRGPRX1	1	0
THYM	Cell metabolism gene	BARHL2	FTMT	0.948683778	7.65E-62
UCS	Cell metabolism gene	BARHL2	FTMT	0.948683778	7.65E-62

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	BARHL2	LHX1	-4.40251078188791	0.000203524868067611
LUAD	BARHL2	LHX9	-1.36992333627046	0.000234488923404754
BLCA	BARHL2	BHLHE22	-2.49529258636956	0.00041961669921875
KICH	BARHL2	NEUROD1	1.11680354284211	0.000482402936961704
LUAD	BARHL2	ATOH7	-1.19629276672305	0.00136933027519666
PRAD	BARHL2	LHX1	2.18457441150947	0.00344452408391648
KIRP	BARHL2	BHLHE22	1.1623407050361	0.00608485564589501
STAD	BARHL2	NEUROD1	-2.00564930401602	0.0093395933508873
CHOL	BARHL2	ELAVL3	-1.81889443645229	0.0224942712224497
READ	BARHL2	NEUROD1	-3.45691881651524	0.03125
STAD	BARHL2	LHX1	-1.72437949567828	0.0321345507332682
BLCA	BARHL2	LHX9	-1.4466579178445	0.0366712945648324
LIHC	BARHL2	PTF1A	-2.15348924414606	0.0376328835201408
LIHC	BARHL2	ATOH7	-5.266584428647	1.07309451780221e-05
PRAD	BARHL2	ELAVL3	-3.27859850042594	1.11239103216112e-05
BRCA	BARHL2	LHX1	-1.90505588371674	1.2018395019931e-08
LUSC	BARHL2	LHX1	-2.6768383989581	1.94224739173131e-05
LUSC	BARHL2	LHX9	-1.77056104357524	2.15531881416327e-06
KIRC	BARHL2	LHX1	-3.65176908454993	2.27289461937239e-13
PRAD	BARHL2	ATOH7	-1.99268410124738	3.051912732609e-06
COAD	BARHL2	NEUROD1	-5.6826865843614	4.17232513427735e-07
LUSC	BARHL2	ATOH7	-9.40445097156362	4.67341425238672e-06
KIRC	BARHL2	NEUROD1	1.73588787383616	4.80499811846172e-08
KIRP	BARHL2	LHX1	-2.83288568065912	5.12227416038514e-08
KICH	BARHL2	BHLHE22	1.34148667268144	5.96046447753906e-07
KIRP	BARHL2	NEUROD1	2.48229664742926	8.55096537772842e-05
KIRP	BARHL2	ELAVL3	1.27555837029132	9.0546440333128e-05
KIRC	BARHL2	PTF1A	-1.00958241526412	9.18050308023753e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with BARHL2

REL, PLEKHF2,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
BARHL2	ESCA	chr1	91182393	91182393	C	T	Silent	p.P120	3
BARHL2	PAAD	chr1	91182141	91182141	G	A	Silent	p.D204D	3
BARHL2	BRCA	chr1	91182376	91182377	-	G	Frame_Shift_Ins	p.Q126fs	3
BARHL2	PCPG	chr1	91180275	91180275	G	A	Missense_Mutation	p.R222C	3
BARHL2	BRCA	chr1	91182534	91182534	C	T	Silent	p.P73	3
BARHL2	SKCM	chr1	91177971	91177971	C	T	Silent	p.R354R	3
BARHL2	PRAD	chr1	91182528	91182528	C	A	Silent	p.P75P	2
BARHL2	UCEC	chr1	91182450	91182450	C	T	Silent	p.P101	2
BARHL2	CESC	chr1	91182143	91182143	C	T	Missense_Mutation		2
BARHL2	SKCM	chr1	91182155	91182155	C	T	Missense_Mutation	p.D200N	2
BARHL2	UCEC	chr1	91182515	91182515	C	T	Missense_Mutation	p.D80N	2
BARHL2	CESC	chr1	91182630	91182630	C	T	Silent		2
BARHL2	SKCM	chr1	91180150	91180150	C	T	Missense_Mutation	p.M263I	2
BARHL2	UCEC	chr1	91182656	91182656	G	A	Missense_Mutation	p.R33C	2
BARHL2	BLCA	chr1	91182500	91182500	G	A	Missense_Mutation	p.H85Y	2
BARHL2	ESCA	chr1	91180292	91180292	C	A	Missense_Mutation	p.R216L	2
BARHL2	CESC	chr1	91182267	91182267	G	A	Silent		2
BARHL2	SARC	chr1	91180171	91180171	G	A	Silent		2
BARHL2	UCEC	chr1	91182684	91182684	G	C	Silent	p.G23	2
BARHL2	CESC	chr1	91182268	91182268	G	A	Missense_Mutation		2
BARHL2	LUAD	chr1	91182622	91182622	C	G	Missense_Mutation	p.R44T	2
BARHL2	CESC	chr1	91182608	91182608	G	C	Missense_Mutation		2
BARHL2	LUAD	chr1	91182132	91182132	G	T	Nonsense_Mutation	p.C207*	2
BARHL2	STAD	chr1	91180282	91180282	C	T	Silent	p.T219T	2
BARHL2	UCEC	chr1	91182708	91182708	C	T	Silent	p.T15	2
BARHL2	BLCA	chr1	91178154	91178154	C	A	Silent	p.V293V	2
BARHL2	CESC	chr1	91182268	91182268	G	A	Missense_Mutation	p.T162I	2
BARHL2	HNSC	chr1	91182551	91182551	C	A	Missense_Mutation	p.V68F	2
BARHL2	STAD	chr1	91180132	91180132	G	A	Silent	p.L269L	2
BARHL2	UCEC	chr1	91177972	91177972	C	T	Missense_Mutation	p.R354Q	2
BARHL2	HNSC	chr1	91180103	91180103	C	T	Nonsense_Mutation	p.W279*	2
BARHL2	STAD	chr1	91178119	91178119	G	A	Missense_Mutation	p.S305L	2
BARHL2	UCEC	chr1	91178005	91178005	C	T	Missense_Mutation	p.R343Q	2
BARHL2	STAD	chr1	91178030	91178030	C	T	Missense_Mutation	p.A335T	2
BARHL2	UCEC	chr1	91180165	91180165	G	T	Missense_Mutation	p.S258R	2
BARHL2	BRCA	chr1	91180220	91180220	G	T	Missense_Mutation	p.S240Y	2
BARHL2	SKCM	chr1	91180266	91180266	G	A	Missense_Mutation	p.P225S	2
BARHL2	HNSC	chr1	91178026	91178026	G	A	Missense_Mutation	p.A336V	2
BARHL2	PCPG	chr1	91180275	91180275	G	A	Missense_Mutation		2
BARHL2	UCEC	chr1	91182159	91182159	C	T	Silent	p.R198	2
BARHL2	SKCM	chr1	91180111	91180111	G	A	Silent	p.V276V	2
BARHL2	STAD	chr1	91180162	91180162	C	T	Silent	p.V259V	2
BARHL2	HNSC	chr1	91182748	91182748	G	T	Missense_Mutation	p.T2K	2
BARHL2	UCEC	chr1	91182270	91182270	G	A	Silent	p.S161	2
BARHL2	LUAD	chr1	91178042	91178042	C	A	Missense_Mutation	p.A331S	2
BARHL2	BLCA	chr1	91178119	91178119	G	C	Missense_Mutation		1
BARHL2	DLBC	chr1	91180266	91180266	G	C	Missense_Mutation	p.P225A	1
BARHL2	GBM	chr1	91182336	91182336	C	T	Silent	p.T139T	1
BARHL2	LUAD	chr1	91182574	91182574	G	T	Missense_Mutation	p.T60K	1
BARHL2	LUSC	chr1	91182612	91182612	G	A	Silent	p.A47A	1
BARHL2	STAD	chr1	91178170	91178170	T	C	Missense_Mutation	p.K288R	1
BARHL2	CHOL	chr1	91182194	91182194	C	G	Missense_Mutation	p.E187Q	1
BARHL2	LGG	chr1	91182144	91182144	G	A	Silent	p.S203S	1
BARHL2	READ	chr1	91182213	91182213	C	A	Missense_Mutation	p.E180D	1
BARHL2	BLCA	chr1	91178154	91178154	C	A	Silent		1
BARHL2	ESCA	chr1	91180220	91180221	-	A	Frame_Shift_Ins	p.S240fs	1
BARHL2	HNSC	chr1	91182748	91182748	G	T	Missense_Mutation		1
BARHL2	LUAD	chr1	91180207	91180207	G	C	Silent	p.L244L	1
BARHL2	LUSC	chr1	91177965	91177965	C	A	Silent	p.L356L	1
BARHL2	THCA	chr1	91180292	91180292	C	A	Missense_Mutation		1
BARHL2	COAD	chr1	91180244	91180244	G	A	Missense_Mutation	p.P232L	1
BARHL2	LGG	chr1	91182144	91182144	G	A	Silent		1
BARHL2	READ	chr1	91182324	91182324	T	A	Missense_Mutation	p.L143F	1
BARHL2	HNSC	chr1	91182551	91182551	C	A	Missense_Mutation		1
BARHL2	LUAD	chr1	91182495	91182495	G	A	Silent	p.H86H	1
BARHL2	SKCM	chr1	91180155	91180155	G	A	Missense_Mutation	p.R262C	1
BARHL2	LUSC	chr1	91180241	91180241	C	A	Missense_Mutation	p.R233L	1
BARHL2	THYM	chr1	91178116	91178116	G	T	Missense_Mutation		1
BARHL2	COAD	chr1	91182225	91182225	G	A	Silent	p.N176N	1
BARHL2	LGG	chr1	91178137	91178137	G	T	Missense_Mutation		1
BARHL2	BLCA	chr1	91178119	91178119	G	C	Missense_Mutation	p.S305W	1
BARHL2	ESCA	chr1	91182354	91182354	C	A	Silent	p.S133	1
BARHL2	HNSC	chr1	91178026	91178026	G	A	Missense_Mutation		1
BARHL2	STAD	chr1	91180282	91180282	C	T	Silent		1
BARHL2	OV	chr1	90952853	90952853	G	C	Missense_Mutation	p.P225R	1
BARHL2	THYM	chr1	91178116	91178116	G	T	Missense_Mutation	p.A306E	1
BARHL2	COAD	chr1	91182325	91182325	A	-	Frame_Shift_Del	p.L143fs	1
BARHL2	LIHC	chr1	91180225	91180225	A	T	Silent	p.A238A	1
BARHL2	SARC	chr1	91177964	91177964	C	A	Missense_Mutation		1
BARHL2	BLCA	chr1	91182553	91182553	G	C	Nonsense_Mutation	p.S67*	1
BARHL2	HNSC	chr1	91180280	91180280	C	T	Missense_Mutation		1
BARHL2	OV	chr1	91178121	91178121	G	C	Nonsense_Mutation	p.Y304*	1
BARHL2	UCEC	chr1	91182159	91182159	C	T	Silent	p.R198R	1
BARHL2	COAD	chr1	91182535	91182535	G	A	Missense_Mutation	p.P73L	1
BARHL2	LIHC	chr1	91182580	91182580	A	G	Missense_Mutation	p.V58A	1
BARHL2	SARC	chr1	91180171	91180171	G	A	Silent	p.Y256Y	1
BARHL2	ESCA	chr1	91182393	91182393	C	T	Silent		1
BARHL2	LUAD	chr1	91177984	91177984	G	T	Missense_Mutation	p.P350H	1
BARHL2	PAAD	chr1	91182141	91182141	G	A	Silent		1
BARHL2	COAD	chr1	91182574	91182574	G	A	Missense_Mutation	p.T60M	1
BARHL2	LIHC	chr1	91178035	91178036	-	C	Frame_Shift_Ins	p.A333fs	1
BARHL2	ESCA	chr1	91180220	91180221	-	-	Frame_Shift_Ins		1
BARHL2	LIHC	chr1	91182635	91182635	T	C	Missense_Mutation	p.T40A	1
BARHL2	SARC	chr1	91177964	91177964	C	A	Missense_Mutation	p.V357L	1
BARHL2	BLCA	chr1	91182377	91182377	G	-	Frame_Shift_Del	p.Q127fs	1
BARHL2	CESC	chr1	91182267	91182267	G	A	Silent	p.T162T	1
BARHL2	LUAD	chr1	91180090	91180090	G	T	Silent	p.R283R	1
BARHL2	COAD	chr1	91182577	91182577	C	T	Missense_Mutation	p.G59E	1
BARHL2	BLCA	chr1	91182377	91182377	G	-	Frame_Shift_Del	p.Q126fs	1
BARHL2	ESCA	chr1	91182354	91182354	C	A	Silent	p.S133S	1
BARHL2	LIHC	chr1	91182720	91182720	A	-	Frame_Shift_Del	p.F11fs	1
BARHL2	SARC	chr1	91180171	91180171	G	A	Silent	p.Y256	1
BARHL2	CESC	chr1	91182143	91182143	C	T	Missense_Mutation	p.D204N	1
BARHL2	HNSC	chr1	91180280	91180280	C	T	Missense_Mutation	p.S220N	1
BARHL2	LUAD	chr1	91178090	91178090	A	T	Missense_Mutation	p.Y315N	1
BARHL2	PAAD	chr1	91180182	91180182	G	A	Missense_Mutation	p.R253W	1
BARHL2	COAD	chr1	91180261	91180262	-	G	Frame_Shift_Ins	p.P226fs	1
BARHL2	ESCA	chr1	91180220	91180221	-	A	Frame_Shift_Ins	p.R240fs	1
BARHL2	LIHC	chr1	91180221	91180221	A	-	Frame_Shift_Del	p.S240fs	1
BARHL2	CESC	chr1	91182267	91182267	G	A	Silent	p.T162	1
BARHL2	LUAD	chr1	91180296	91180296	C	A	Missense_Mutation	p.D215Y	1
BARHL2	STAD	chr1	91182644	91182644	C	T	Missense_Mutation	p.E37K	1
BARHL2	BLCA	chr1	91182264	91182264	G	A	Silent		1
BARHL2	COAD	chr1	91182588	91182588	A	C	Missense_Mutation	p.I55M	1
BARHL2	GBM	chr1	91182597	91182597	A	G	Silent	p.C52C	1
BARHL2	LIHC	chr1	91182521	91182521	C	-	Frame_Shift_Del	p.V78fs	1
BARHL2	CESC	chr1	91182448	91182448	G	A	Missense_Mutation	p.T102M	1
BARHL2	LUAD	chr1	91180292	91180292	C	G	Missense_Mutation	p.R216P	1
BARHL2	BLCA	chr1	91182500	91182500	G	A	Missense_Mutation		1
BARHL2	COAD	chr1	91182715	91182715	A	G	Missense_Mutation	p.I13T	1
BARHL2	GBM	chr1	91182732	91182732	G	A	Silent	p.S7S	1
BARHL2	LUSC	chr1	91182202	91182202	G	T	Missense_Mutation	p.P184Q	1
BARHL2	STAD	chr1	91182241	91182241	G	A	Missense_Mutation	p.P171L	1
BARHL2	CESC	chr1	91182608	91182608	G	C	Missense_Mutation	p.P49A	1
BARHL2	HNSC	chr1	91182382	91182384	GGC	-	In_Frame_Del	p.PP123del	1

Copy number variation (CNV) of BARHL2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across BARHL2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	BARHL2	0.0196582165414147	0.55
BLCA	BARHL2	0.0372684158129372	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PRAD	BARHL2	0.0353850694233184	1
SKCM	BARHL2	1.62053615884905e-05	0.00053
OV	BARHL2	0.0446354684557668	1
COAD	BARHL2	0.00604145741986992	0.19

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source