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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PAIP2B (NCBI Gene ID:400961)

Gene Summary

Gene Summary

Gene Information	Gene Name: PAIP2B
	Gene ID: 400961
	Gene Symbol	PAIP2B
	Gene ID	400961
	Gene Name	poly(A) binding protein interacting protein 2B
	Synonyms	-
	Cytomap	2p13.3
	Type of Gene	protein-coding
	Description	polyadenylate-binding protein-interacting protein 2BPABP-interacting protein 2BPAIP-2B
	Modification date	20200313
	UniProtAcc	Q9ULR5

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PAIP2B	GO:0045947	negative regulation of translational initiation	16804161

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PAIP2B	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'PAIP2B[title] AND translation [title] AND human.'

Gene	Title	PMID
PAIP2B	Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B	16804161

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000244221	71416974	71417151	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000244221	71416974	71417151	6296	306	482	123	46	105

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9ULR5	46	105	1	123	Chain	ID=PRO_0000317294;Note=Polyadenylate-binding protein-interacting protein 2B

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	PAIP2B	-1.69646345303634	1.30745672886698e-07
BRCA	PAIP2B	-3.71582848478141	1.80409282930263e-11
LIHC	PAIP2B	-2.98833419208047	8.51524921447167e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	PAIP2B	hsa-miR-27b-3p	94	0.411077705827937	0.00438038012736457

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
ESCA	PAIP2B	2	1	0.00140416372017687	0.323246481178396	0.160252053771471	-1.74568092710799	-1.15065940262925

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BRCA	PAIP2B	0.012503297	0.011437702

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PAIP2B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	PAIP2B	HADH	0.801135728	3.86E-11
CHOL	Cell metabolism gene	PAIP2B	CTH	0.801896548	3.59E-11
CHOL	Cell metabolism gene	PAIP2B	AASS	0.80270751	3.31E-11
CHOL	Cell metabolism gene	PAIP2B	ACACB	0.805858918	2.42E-11
CHOL	Cell metabolism gene	PAIP2B	PROS1	0.808065972	1.94E-11
CHOL	Cell metabolism gene	PAIP2B	ACOX2	0.808543071	1.85E-11
CHOL	Cell metabolism gene	PAIP2B	ACSM5	0.809795618	1.63E-11
CHOL	Cell metabolism gene	PAIP2B	HIBCH	0.810393398	1.53E-11
CHOL	Cell metabolism gene	PAIP2B	SLC25A13	0.812529029	1.23E-11
CHOL	Cell metabolism gene	PAIP2B	PEX11A	0.813479413	1.11E-11
CHOL	Cell metabolism gene	PAIP2B	MTHFD1	0.814011953	1.05E-11
CHOL	Cell metabolism gene	PAIP2B	GLS2	0.819541807	5.83E-12
CHOL	Cell metabolism gene	PAIP2B	ABCB11	0.820347355	5.34E-12
CHOL	Cell metabolism gene	PAIP2B	BCKDHB	0.821301476	4.81E-12
CHOL	Cell metabolism gene	PAIP2B	ALDH5A1	0.821339959	4.79E-12
CHOL	Cell metabolism gene	PAIP2B	RAPGEF4	0.822848878	4.06E-12
CHOL	Cell metabolism gene	PAIP2B	CAT	0.823789039	3.66E-12
CHOL	Cell metabolism gene	PAIP2B	LPA	0.824011022	3.57E-12
CHOL	Cell metabolism gene	PAIP2B	DGAT2	0.828484522	2.15E-12
CHOL	Cell metabolism gene	PAIP2B	PLIN1	0.829094014	2.01E-12
CHOL	Cell metabolism gene	PAIP2B	ALDH7A1	0.830852476	1.64E-12
CHOL	Cell metabolism gene	PAIP2B	UPB1	0.831385765	1.54E-12
CHOL	Cell metabolism gene	PAIP2B	ALDH6A1	0.831959122	1.44E-12
CHOL	Cell metabolism gene	PAIP2B	EHHADH	0.832071703	1.42E-12
CHOL	Cell metabolism gene	PAIP2B	ALDH2	0.832090052	1.42E-12
CHOL	Cell metabolism gene	PAIP2B	DBH	0.832182559	1.40E-12
CHOL	Cell metabolism gene	PAIP2B	ADI1	0.832525643	1.34E-12
CHOL	Cell metabolism gene	PAIP2B	SARDH	0.833510227	1.20E-12
CHOL	Cell metabolism gene	PAIP2B	AGL	0.834111723	1.11E-12
CHOL	Cell metabolism gene	PAIP2B	ENPP1	0.837362725	7.54E-13
CHOL	Cell metabolism gene	PAIP2B	MOCS2	0.838616259	6.47E-13
CHOL	Cell metabolism gene	PAIP2B	PCK2	0.838622849	6.46E-13
CHOL	Cell metabolism gene	PAIP2B	ABAT	0.839353616	5.91E-13
CHOL	Cell metabolism gene	PAIP2B	SORD	0.841816582	4.35E-13
CHOL	Cell metabolism gene	PAIP2B	MCEE	0.846106883	2.52E-13
CHOL	Cell metabolism gene	PAIP2B	HSD17B4	0.847307418	2.16E-13
CHOL	Cell metabolism gene	PAIP2B	ACSL1	0.858187991	4.93E-14
CHOL	Cell metabolism gene	PAIP2B	ACADSB	0.874123622	4.49E-15
CHOL	CGC	PAIP2B	ESR1	0.817655641	7.15E-12
CHOL	CGC	PAIP2B	ALDH2	0.832090052	1.42E-12
CHOL	Epifactor	PAIP2B	CECR2	0.813469735	1.11E-11
CHOL	IUPHAR	PAIP2B	CYP1A1	0.800481964	4.12E-11
CHOL	IUPHAR	PAIP2B	SFXN1	0.801070892	3.89E-11
CHOL	IUPHAR	PAIP2B	LEPR	0.801342349	3.79E-11
CHOL	IUPHAR	PAIP2B	SLC25A42	0.801458575	3.74E-11
CHOL	IUPHAR	PAIP2B	CTH	0.801896548	3.59E-11
CHOL	IUPHAR	PAIP2B	ENPEP	0.805475097	2.52E-11
CHOL	IUPHAR	PAIP2B	ACACB	0.805858918	2.42E-11
CHOL	IUPHAR	PAIP2B	SLC6A13	0.809740508	1.64E-11
CHOL	IUPHAR	PAIP2B	ADRA1A	0.810334361	1.54E-11
CHOL	IUPHAR	PAIP2B	SLC25A13	0.812529029	1.23E-11
CHOL	IUPHAR	PAIP2B	CECR2	0.813469735	1.11E-11
CHOL	IUPHAR	PAIP2B	FOLH1B	0.814871461	9.61E-12
CHOL	IUPHAR	PAIP2B	AQP9	0.815946802	8.58E-12
CHOL	IUPHAR	PAIP2B	ESR1	0.817655641	7.15E-12
CHOL	IUPHAR	PAIP2B	ABCB11	0.820347355	5.34E-12
CHOL	IUPHAR	PAIP2B	CHRNA4	0.820504945	5.25E-12
CHOL	IUPHAR	PAIP2B	ALDH5A1	0.821339959	4.79E-12
CHOL	IUPHAR	PAIP2B	RAPGEF4	0.822848878	4.06E-12
CHOL	IUPHAR	PAIP2B	CAT	0.823789039	3.66E-12
CHOL	IUPHAR	PAIP2B	ALDH2	0.832090052	1.42E-12
CHOL	IUPHAR	PAIP2B	DBH	0.832182559	1.40E-12
CHOL	IUPHAR	PAIP2B	CYP39A1	0.83908	6.11E-13
CHOL	IUPHAR	PAIP2B	ABAT	0.839353616	5.91E-13
CHOL	IUPHAR	PAIP2B	WNK3	0.840111593	5.38E-13
CHOL	IUPHAR	PAIP2B	ABCA6	0.857582132	5.37E-14
CHOL	Kinase	PAIP2B	WNK3	0.840111593	5.38E-13
CHOL	TF	PAIP2B	ESR1	0.817655641	7.15E-12
CHOL	TF	PAIP2B	ARID3C	0.860235973	3.69E-14
CHOL	TSG	PAIP2B	BMP10	0.800556589	4.09E-11
CHOL	TSG	PAIP2B	ESR1	0.817655641	7.15E-12
CHOL	TSG	PAIP2B	GLS2	0.819541807	5.83E-12
CHOL	TSG	PAIP2B	CAT	0.823789039	3.66E-12
UVM	CGC	PAIP2B	RAF1	0.809604549	9.90E-20
UVM	Epifactor	PAIP2B	SATB1	0.823894885	6.31E-21
UVM	IUPHAR	PAIP2B	RAF1	0.809604549	9.90E-20
UVM	IUPHAR	PAIP2B	SCN8A	0.848311937	3.06E-23
UVM	Kinase	PAIP2B	RAF1	0.809604549	9.90E-20
UVM	TF	PAIP2B	ZXDC	0.813847174	4.48E-20
UVM	TF	PAIP2B	SATB1	0.823894885	6.31E-21
UVM	TSG	PAIP2B	MTUS1	0.800431546	5.15E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	PAIP2B	PABPC4	-1.36755201178157	0.000287055969238281
BRCA	PAIP2B	PABPC3	-3.84163884772227	0.000688782698821282
KIRC	PAIP2B	PAIP1	-5.71279064132007	0.00220467399393826
CHOL	PAIP2B	ATP1B3	-2.61811327561277	0.00390625
CHOL	PAIP2B	PABPC1	-4.56272528815353	0.00390625
PRAD	PAIP2B	SLC1A1	1.19209763248206	0.00731863099602977
CHOL	PAIP2B	PABPC3	-1.20689409625496	0.0078125
BLCA	PAIP2B	PABPC1	1.31485302792746	0.0180816650390625
CHOL	PAIP2B	PABPC1L	2.78331172494241	0.01953125
BLCA	PAIP2B	ADCY6	-1.62400696905527	0.0445594787597656
BLCA	PAIP2B	SLC1A1	1.55522368404335	0.0493659973144531
LIHC	PAIP2B	SLC1A1	-1.19036601324842	1.22318557765184e-07
LUAD	PAIP2B	PABPC1L	-2.51583026501524	1.30692790027182e-05
KIRC	PAIP2B	PABPC4	-1.49233512628432	1.55238188425888e-10
BRCA	PAIP2B	PAIP1	1.33783668607252	1.59729685534959e-08
COAD	PAIP2B	PABPC4	-2.03666372801907	2.27093696594239e-05
THCA	PAIP2B	SLC1A1	-1.7343174708438	2.31189407147357e-09
PRAD	PAIP2B	ADCY6	1.18317002132968	2.74398347191128e-05
LUSC	PAIP2B	ATP1B3	3.12707108226298	2.79558697199975e-08
LIHC	PAIP2B	ADCY6	-2.37342600043136	2.84633422781438e-08
LIHC	PAIP2B	PABPC1	-1.72076961362188	2.98009622125841e-06
KIRP	PAIP2B	PABPC4	-2.80798320382911	2.98023223876953e-07
COAD	PAIP2B	ADCY6	-1.18375769948934	3.27825546264649e-06
LUSC	PAIP2B	PABPC1L	-2.50538171229714	3.79466966402315e-05
STAD	PAIP2B	PABPC1L	-2.43245436541992	4.02145087718964e-06
THCA	PAIP2B	PABPC4	-4.00250200468713	4.88626066707067e-07
COAD	PAIP2B	SLC1A1	-3.0474153272514	5.03659248352051e-06
LUAD	PAIP2B	SLC1A1	-3.30084545077193	5.75269129094147e-11
COAD	PAIP2B	ATP1B3	-1.17237984360016	6.03199005126954e-05
LIHC	PAIP2B	PABPC1L	-2.77562492714404	6.17267413816717e-05
HNSC	PAIP2B	ADCY6	1.65007439277528	6.70008830638836e-08
BRCA	PAIP2B	ADCY6	-1.38824996309554	7.02901412007711e-19
KICH	PAIP2B	PABPC1L	2.22531868187715	7.49826431274414e-05
PRAD	PAIP2B	PABPC1	-2.10200318363476	8.55379952759014e-07
KIRC	PAIP2B	ADCY6	-2.27287322399259	9.27019571822147e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PAIP2B

PABPC1, HNRNPA1, DND1, LUC7L2, ELAVL2, CELF5, CIRBP, RBM3, SNIP1, PAIP2, C17orf85, H2AFB3, CASC3, MKRN1, RBMS2, PABPC4L, SREK1, PABPC1L, H2AFX, CLK3, CLK2, MOV10, PDCD11, MKRN2, UPF1, ZNF326, MRPL11, ZCCHC3, ALYREF, SRSF1, PRR3, LARP4B, BCLAF1, YTHDC1, NCBP1, LARP1, PUM2, LARP1B, SCAF1, RBMXL1, H2AFB2, PURG, PABPC5, ZC3H11A, PAIP1, YBX1, FAM120A, HNRNPCL1, ZFR, DKC1, PABPC4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PAIP2B	PAAD	chr2	71417026	71417026	C	T	Silent	p.Q88Q	2
PAIP2B	BLCA	chr2	71415650	71415650	T	C	Missense_Mutation	p.N111D	2
PAIP2B	SKCM	chr2	71429639	71429639	C	T	Silent	p.K27K	2
PAIP2B	SKCM	chr2	71417122	71417122	G	A	Silent	p.F56F	2
PAIP2B	HNSC	chr2	71429712	71429712	C	A	Missense_Mutation	p.G3V	2
PAIP2B	CESC	chr2	71417103	71417103	C	G	Missense_Mutation		2
PAIP2B	LIHC	chr2	71417134	71417134	C	T	Silent		2
PAIP2B	UCEC	chr2	71415636	71415636	C	A	Missense_Mutation	p.K115N	2
PAIP2B	UCEC	chr2	71417072	71417072	A	C	Missense_Mutation	p.F73C	2
PAIP2B	UCEC	chr2	71429712	71429712	C	T	Missense_Mutation	p.G3E	2
PAIP2B	COAD	chr2	71429650	71429650	G	A	Missense_Mutation	p.H24Y	1
PAIP2B	LUAD	chr2	71429701	71429701	C	A	Missense_Mutation	p.A7S	1
PAIP2B	DLBC	chr2	71415619	71415619	T	C	Missense_Mutation	p.E121G	1
PAIP2B	ESCA	chr2	71417056	71417056	G	T	Missense_Mutation	p.D78E	1
PAIP2B	SARC	chr2	71417113	71417113	G	T	Silent		1
PAIP2B	ESCA	chr2	71417056	71417056	G	T	Missense_Mutation		1
PAIP2B	BLCA	chr2	71429644	71429644	C	T	Missense_Mutation	p.E26K	1
PAIP2B	GBM	chr2	71429660	71429660	C	T	Silent		1
PAIP2B	BLCA	chr2	71417133	71417133	C	T	Missense_Mutation	p.E53K	1
PAIP2B	HNSC	chr2	71429712	71429712	C	A	Missense_Mutation		1
PAIP2B	SKCM	chr2	71417066	71417066	G	A	Missense_Mutation	p.P75L	1
PAIP2B	CESC	chr2	71429694	71429694	G	T	Missense_Mutation		1
PAIP2B	SKCM	chr2	71417067	71417067	G	A	Missense_Mutation	p.P75S	1
PAIP2B	KIRP	chr2	71417143	71417143	C	A	Missense_Mutation		1
PAIP2B	TGCT	chr2	71417065	71417065	G	T	Silent		1
PAIP2B	CESC	chr2	71417103	71417103	C	G	Missense_Mutation	p.E63Q	1
PAIP2B	COAD	chr2	71417008	71417008	T	C	Silent	p.S94S	1
PAIP2B	LIHC	chr2	71429687	71429687	C	G	Silent		1
PAIP2B	COAD	chr2	71417134	71417134	C	T	Silent	p.Q52Q	1
PAIP2B	LUAD	chr2	71415647	71415647	G	T	Missense_Mutation	p.P112T	1

Copy number variation (CNV) of PAIP2B
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PAIP2B
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
98397	N/A	AV689750	G2E3	chr14	31074777	+	PAIP2B	chr2	71442078	+
85212	N/A	AI525177	PAIP2B	chr2	71415858	-	PSME4	chr2	54174602	-
97771	N/A	H19903	PAIP2B	chr2	71412679	-	YEATS2	chr3	183529985	+
98397	N/A	AI804731	TANGO6	chr16	68900174	+	PAIP2B	chr2	71413987	+
98397	UCEC	TCGA-BG-A3PP-01A	VAX2	chr2	71127998	+	PAIP2B	chr2	71429730	-
98398	N/A	AK094335	VPS36	chr13	53004085	-	PAIP2B	chr2	71454201	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	PAIP2B	0.00022082357398957	0.0062
TGCT	PAIP2B	0.000592223003729502	0.016
SARC	PAIP2B	0.0138486893837552	0.36
THYM	PAIP2B	0.0189541218541445	0.47
BRCA	PAIP2B	0.0227561259992179	0.55
LIHC	PAIP2B	0.0368001890982104	0.85

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LAML	PAIP2B	0.0426802089501672	1
BRCA	PAIP2B	0.0184018785157734	0.61

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source