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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CAPRIN1 (NCBI Gene ID:4076)

Gene Summary

Gene Summary

Gene Information	Gene Name: CAPRIN1
	Gene ID: 4076
	Gene Symbol	CAPRIN1
	Gene ID	4076
	Gene Name	cell cycle associated protein 1
	Synonyms	GPIAP1\|GPIP137\|GRIP137\|M11S1\|RNG105\|p137GPI
	Cytomap	11p13
	Type of Gene	protein-coding
	Description	caprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation-
	Modification date	20200313
	UniProtAcc	Q14444

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CAPRIN1	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'CAPRIN1[title] AND translation [title] AND human.'

Gene	Title	PMID
CAPRIN1	Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation	31439799

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000341394	34101174	34101312	In-frame
ENST00000532820	34101174	34101312	In-frame
ENST00000341394	34104371	34104424	Frame-shift
ENST00000532820	34104371	34104424	Frame-shift
ENST00000341394	34104501	34104588	In-frame
ENST00000532820	34104501	34104588	In-frame
ENST00000341394	34112075	34112225	In-frame
ENST00000532820	34112075	34112225	In-frame
ENST00000341394	34113452	34113603	Frame-shift
ENST00000532820	34113452	34113603	Frame-shift
ENST00000341394	34118742	34118843	Frame-shift
ENST00000532820	34118742	34118843	Frame-shift
ENST00000341394	34119244	34119308	Frame-shift
ENST00000532820	34119244	34119308	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000532820	34101174	34101312	3455	900	1037	709	229	275
ENST00000341394	34101174	34101312	4125	878	1015	709	229	275
ENST00000532820	34104501	34104588	3455	1091	1177	709	293	322
ENST00000341394	34104501	34104588	4125	1069	1155	709	293	322
ENST00000532820	34112075	34112225	3455	1616	1765	709	468	518
ENST00000341394	34112075	34112225	4125	1594	1743	709	468	518

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q14444	468	518	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
Q14444	293	322	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
Q14444	229	275	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
Q14444	468	518	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
Q14444	293	322	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
Q14444	229	275	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
Q14444	229	275	263	263	Natural variant	ID=VAR_042425;Note=A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:7657653;Dbxref=dbSNP:rs1132973,PMID:7657653
Q14444	229	275	263	263	Natural variant	ID=VAR_042425;Note=A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:7657653;Dbxref=dbSNP:rs1132973,PMID:7657653
Q14444	229	275	230	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4WBE
Q14444	229	275	230	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4WBE
Q14444	229	275	245	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4WBE
Q14444	229	275	245	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4WBE

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	CAPRIN1	-1.92523643204408	0.00390625
KICH	CAPRIN1	1.804235261744	0.00882232189178467
BLCA	CAPRIN1	-3.69281210398604	0.0180816650390625
BRCA	CAPRIN1	1.61631170705267	5.15475086615707e-17

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUSC	CAPRIN1	-0.192420102	0.009204427

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CAPRIN1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	CGC	CAPRIN1	FANCF	0.82473395	3.29E-12
DLBC	Cell metabolism gene	CAPRIN1	EP300	0.81250808	2.36E-12
DLBC	Cell metabolism gene	CAPRIN1	AASDHPPT	0.819919259	1.02E-12
DLBC	Cell metabolism gene	CAPRIN1	TNPO1	0.820830842	9.14E-13
DLBC	CGC	CAPRIN1	CDK12	0.801893212	7.41E-12
DLBC	CGC	CAPRIN1	SUZ12	0.803135987	6.50E-12
DLBC	CGC	CAPRIN1	EP300	0.81250808	2.36E-12
DLBC	CGC	CAPRIN1	NUP98	0.820466071	9.54E-13
DLBC	Epifactor	CAPRIN1	SUZ12	0.803135987	6.50E-12
DLBC	Epifactor	CAPRIN1	EP300	0.81250808	2.36E-12
DLBC	IUPHAR	CAPRIN1	CDK12	0.801893212	7.41E-12
DLBC	IUPHAR	CAPRIN1	EP300	0.81250808	2.36E-12
DLBC	IUPHAR	CAPRIN1	ATP2A2	0.830808794	2.74E-13
DLBC	Kinase	CAPRIN1	CDK12	0.801893212	7.41E-12
DLBC	TF	CAPRIN1	AHCTF1	0.855482027	9.67E-15
DLBC	TSG	CAPRIN1	SUZ12	0.803135987	6.50E-12
DLBC	TSG	CAPRIN1	NUP98	0.820466071	9.54E-13
TGCT	TF	CAPRIN1	ZBTB39	0.802544312	2.27E-36
TGCT	TF	CAPRIN1	ZNF570	0.806366025	5.90E-37
THCA	Cell metabolism gene	CAPRIN1	PIK3CA	0.803388148	1.92E-130
THCA	CGC	CAPRIN1	PIK3CA	0.803388148	1.92E-130
THCA	IUPHAR	CAPRIN1	PIK3CA	0.803388148	1.92E-130
THYM	Cell metabolism gene	CAPRIN1	RQCD1	0.800154585	2.07E-28
THYM	CGC	CAPRIN1	FUBP1	0.815229121	3.04E-30
THYM	IUPHAR	CAPRIN1	PRMT3	0.809959125	1.39E-29
THYM	TF	CAPRIN1	PRMT3	0.809959125	1.39E-29
UCS	Cell metabolism gene	CAPRIN1	RQCD1	0.800154585	2.07E-28
UCS	CGC	CAPRIN1	FUBP1	0.815229121	3.04E-30
UCS	IUPHAR	CAPRIN1	PRMT3	0.809959125	1.39E-29
UCS	TF	CAPRIN1	PRMT3	0.809959125	1.39E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	CAPRIN1	TIA1	-7.74840540416154	0.000209558356255901
HNSC	CAPRIN1	G3BP1	1.15470167292163	0.000481783007217019
KICH	CAPRIN1	FMR1	1.78310178813069	0.00102710723876953
LIHC	CAPRIN1	FXR1	-1.34222849900153	0.00221270975997039
THCA	CAPRIN1	G3BP2	-2.67399822837565	0.00541201428545656
KIRP	CAPRIN1	FMR1	-1.94284822624948	0.0099095250479877
CHOL	CAPRIN1	HTT	-1.06148752250872	0.01171875
ESCA	CAPRIN1	HTT	-1.11267300323171	0.013671875
BRCA	CAPRIN1	HTT	-1.12770251374077	0.020837402758111
LUAD	CAPRIN1	TIA1	-1.21695463712876	0.0252511614440066
HNSC	CAPRIN1	FXR1	1.42033860536739	0.03633773249976
COAD	CAPRIN1	FXR2	1.01105544222868	0.0407472252845765
BRCA	CAPRIN1	FMR1	-2.74053611255086	0.0481383834499222
KIRC	CAPRIN1	FMR1	-2.35406916543664	1.12145348829767e-07
HNSC	CAPRIN1	FMR1	-2.72606987034586	1.37760207508109e-06
PRAD	CAPRIN1	G3BP1	-4.29883961189402	2.3360983838936e-06
KIRC	CAPRIN1	G3BP2	-1.84572102919607	5.25218264171243e-09
STAD	CAPRIN1	G3BP1	-3.96377290273826	6.0301274061203e-05
KIRC	CAPRIN1	FXR1	-1.91678508891597	7.23860956542035e-06
LUAD	CAPRIN1	FXR1	-1.55340065062105	7.61068774930263e-05
LIHC	CAPRIN1	HTT	-6.76350618083823	7.84143794524039e-06
BRCA	CAPRIN1	G3BP2	1.42064019612141	7.90152668692313e-05
KICH	CAPRIN1	TIA1	1.65667515704362	8.16583633422851e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CAPRIN1

PINX1, PRMT1, G3BP1, GIGYF2, AI837181, SIRT7, TSG101, CUL3, CUL1, COPS5, CAND1, APP, CIRBP, ESR1, IGSF8, FBXO6, TARDBP, WBP4, PIN1, rev, RPA3, RPA2, RPA1, FXR1, FXR2, STAU1, RNF2, BMI1, SIRT6, CDK2, ILK, RPS6KB2, HNRNPA1, NTRK1, RPL7, Rrbp1, YBX1, NF2, EGFR, CYLD, DNM1L, BRCA1, RPS6, G3BP2, CLEC14A, SPOP, PTPN4, PHACTR3, WDR77, CTNNB1, MED12, ZNF217, UBE2M, PRPF8, AAR2, PIH1D1, EFTUD2, CHD3, CHD4, DAPK1, MFHAS1, HEXIM1, MEPCE, LARP7, RECQL4, PIK3R1, GPC1, ZFP36L2, MYC, TP63, KIAA1429, RC3H1, RC3H2, PHB, USP14, ZBTB10, HDAC2, GBAS, OAS3, MAB21L2, SNRNP70, FUS, ITFG1, GSK3B, BIRC3, NFX1, WWP2, BRD7, SOX2, N, HCVgp1, ORF50, DUSP1, DUSP6, ABTB1, C6orf222, RBM25, PES1, STAG2, ANKRD17, ANKHD1-EIF4EBP3, ATXN2, CCSER2, CNOT1, DDX20, DHX57, EIF4ENIF1, FAM120A, FMR1, IBTK, KTN1, LARP4, LARP4B, LSM12, MTDH, OTUD4, PRRC2A, PRRC2B, PRRC2C, WIBG, SCAPER, SMG7, SND1, TDRD3, TNRC6B, TOP3B, UBAP2L, UPF1, USP10, YTHDF2, ZC3H7A, ZCCHC3, ZCCHC6, ZNF598, DAZL, DDX3X, LSM14A, MEX3B, MKRN2, NUFIP2, PUM1, RBMS1, YTHDF3, ZC3HAV1, AHCYL1, CNOT3, EIF2A, LARP1B, LSM14B, SECISBP2, CELF1, FUBP3, IGF2BP2, YTHDF1, CNOT10, RQCD1, DHX29, CSDE1, PABPC1, SYNCRIP, UNK, UBAP2, FAM120C, IGF2BP1, LRRC31, DUX4, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, IFI16, MNDA, GRSF1, MKI67, LDLR, LRRC59, BRD4, NUPR1, Apc2, FBP1, LGALS9, GRB7, BKRF1, DNAJA3, DNAJB13, DNAJB3, DNAJB6, DNAJB8, DNAJC12, DNAJC24, DNAJC27, SEC63, PDZD9, CD274, UFL1, DDRGK1, FBL, RPS20, RPS24, SERBP1, FZR1, WDR5, NUDCD2, BTF3, NBR1, OPTN, EIF2AK2, nsp14, DVL2, KLF15, KLF16, KLF8, SOX5, SOX6,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
CAPRIN1	chr11	34101297	C	T	single_nucleotide_variant	Likely_pathogenic	Moyamoya_angiopathy	SO:0001587\|nonsense	SO:0001587\|nonsense
CAPRIN1	chr11	34107785	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
CAPRIN1	chr11	34118790	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
CAPRIN1	chr11	34119290	C	A	single_nucleotide_variant	Uncertain_significance	See_cases	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CAPRIN1	BRCA	chr11	34093289	34093289	A	G	Missense_Mutation	p.Y78C	4
CAPRIN1	KIRP	chr11	34118752	34118752	A	G	Missense_Mutation	p.D637G	4
CAPRIN1	UCEC	chr11	34110996	34110996	C	T	Missense_Mutation	p.A429V	3
CAPRIN1	BRCA	chr11	34107665	34107679	CCCCACTCTTTGACT	-	In_Frame_Del	p.HSLTP342in_frame_del	3
CAPRIN1	BRCA	chr11	34113522	34113522	C	G	Missense_Mutation	p.Q542E	3
CAPRIN1	HNSC	chr11	34107680	34107680	C	G	Missense_Mutation	p.P346A	3
CAPRIN1	LIHC	chr11	34101204	34101204	G	A	Missense_Mutation		3
CAPRIN1	LIHC	chr11	34101204	34101204	G	A	Missense_Mutation	p.V240I	3
CAPRIN1	ESCA	chr11	34093524	34093524	T	C	Missense_Mutation	p.L119P	3
CAPRIN1	PAAD	chr11	34107957	34107957	C	G	Missense_Mutation	p.P410A	3
CAPRIN1	ESCA	chr11	34107731	34107731	A	G	Missense_Mutation	p.M363V	3
CAPRIN1	ESCA	chr11	34118131	34118131	A	G	Missense_Mutation	p.Y604C	3
CAPRIN1	LIHC	chr11	34107925	34107925	A	-	Frame_Shift_Del	p.Q399fs	2
CAPRIN1	SARC	chr11	34107860	34107860	G	T	Missense_Mutation		2
CAPRIN1	UCEC	chr11	34118841	34118841	C	G	Missense_Mutation	p.R667G	2
CAPRIN1	STAD	chr11	34112103	34112103	A	C	Missense_Mutation	p.T478P	2
CAPRIN1	ESCA	chr11	34119305	34119305	C	T	Nonsense_Mutation	p.R688*	2
CAPRIN1	SKCM	chr11	34113512	34113512	A	G	Silent	p.Q538Q	2
CAPRIN1	UCEC	chr11	34119324	34119324	G	A	Nonsense_Mutation	p.W694*	2
CAPRIN1	STAD	chr11	34093453	34093453	C	T	Silent	p.A95A	2
CAPRIN1	ESCA	chr11	34074014	34074014	G	T	Missense_Mutation	p.G16V	2
CAPRIN1	UCEC	chr11	34120902	34120902	G	T	Missense_Mutation	p.Q706H	2
CAPRIN1	ESCA	chr11	34118131	34118131	A	G	Missense_Mutation		2
CAPRIN1	UCEC	chr11	34093513	34093513	T	G	Missense_Mutation	p.S115R	2
CAPRIN1	SKCM	chr11	34113478	34113478	C	T	Missense_Mutation	p.P527L	2
CAPRIN1	UCEC	chr11	34120908	34120908	G	T	Silent	p.V708	2
CAPRIN1	CESC	chr11	34120902	34120902	G	A	Silent		2
CAPRIN1	ESCA	chr11	34098007	34098007	G	A	Silent		2
CAPRIN1	UCEC	chr11	34097897	34097897	G	T	Missense_Mutation	p.D161Y	2
CAPRIN1	BLCA	chr11	34110948	34110948	C	G	Missense_Mutation	p.S413C	2
CAPRIN1	CESC	chr11	34097786	34097786	C	G	Missense_Mutation		2
CAPRIN1	ESCA	chr11	34093524	34093524	T	C	Missense_Mutation		2
CAPRIN1	SKCM	chr11	34101304	34101304	C	G	Missense_Mutation	p.P273R	2
CAPRIN1	UCEC	chr11	34101202	34101202	G	A	Missense_Mutation	p.R239H	2
CAPRIN1	UCS	chr11	34093499	34093499	G	T	Nonsense_Mutation	p.E111*	2
CAPRIN1	CESC	chr11	34097834	34097834	G	C	Missense_Mutation		2
CAPRIN1	UCEC	chr11	34107631	34107631	G	T	Missense_Mutation	p.Q329H	2
CAPRIN1	ESCA	chr11	34107731	34107731	A	G	Missense_Mutation		2
CAPRIN1	LUAD	chr11	34118027	34118027	G	T	Splice_Site	p.V569_splice	2
CAPRIN1	CESC	chr11	34119297	34119297	G	A	Missense_Mutation		2
CAPRIN1	LIHC	chr11	34074178	34074178	A	-	Frame_Shift_Del	p.K72fs	2
CAPRIN1	SKCM	chr11	34119268	34119268	G	A	Silent	p.K675K	2
CAPRIN1	UCEC	chr11	34107766	34107766	G	T	Missense_Mutation	p.Q374H	2
CAPRIN1	LUAD	chr11	34101277	34101277	C	T	Missense_Mutation	p.S264L	2
CAPRIN1	STAD	chr11	34097814	34097814	G	A	Missense_Mutation		2
CAPRIN1	THYM	chr11	34118841	34118841	C	T	Missense_Mutation		2
CAPRIN1	ACC	chr11	34104425	34104425	G	T	Splice_Site	.	2
CAPRIN1	CHOL	chr11	34074072	34074072	C	T	Silent	p.A35A	2
CAPRIN1	LIHC	chr11	34097917	34097917	C	-	Frame_Shift_Del	p.D167fs	2
CAPRIN1	UCEC	chr11	34118080	34118080	A	G	Missense_Mutation	p.H587R	2
CAPRIN1	ESCA	chr11	34098007	34098007	G	A	Silent	p.R197R	2
CAPRIN1	STAD	chr11	34097814	34097814	G	A	Missense_Mutation	p.R133Q	2
CAPRIN1	ACC	chr11	34097794	34097795	AA	-	Frame_Shift_Del	p.126_126del	2
CAPRIN1	PAAD	chr11	34118047	34118047	C	-	Frame_Shift_Del	p.S576fs	2
CAPRIN1	CHOL	chr11	34110974	34110974	C	A	Missense_Mutation	p.Q422K	2
CAPRIN1	UCEC	chr11	34118181	34118181	T	C	Silent	p.L621	2
CAPRIN1	STAD	chr11	34107866	34107866	T	C	Silent	p.D379D	2
CAPRIN1	THYM	chr11	34118841	34118841	C	T	Missense_Mutation	p.R667W	2
CAPRIN1	BLCA	chr11	34113462	34113462	A	G	Missense_Mutation	p.M522V	2
CAPRIN1	CHOL	chr11	34101180	34101180	G	C	Missense_Mutation	p.V232L	2
CAPRIN1	UCEC	chr11	34118196	34118196	C	T	Missense_Mutation	p.R626W	2
CAPRIN1	GBM	chr11	34098006	34098006	G	A	Missense_Mutation		2
CAPRIN1	BLCA	chr11	34097866	34097866	T	C	Silent	p.L150L	1
CAPRIN1	COAD	chr11	34097909	34097909	C	T	Missense_Mutation	p.R165W	1
CAPRIN1	SKCM	chr11	34104504	34104504	T	G	Nonsense_Mutation	p.Y294*	1
CAPRIN1	HNSC	chr11	34107680	34107680	C	G	Missense_Mutation		1
CAPRIN1	LUAD	chr11	34101264	34101264	G	C	Missense_Mutation	p.E260Q	1
CAPRIN1	LGG	chr11	34118078	34118078	C	T	Silent	p.N586N	1
CAPRIN1	READ	chr11	34120908	34120908	G	T	Silent	p.V708V	1
CAPRIN1	BLCA	chr11	34113462	34113462	A	G	Missense_Mutation		1
CAPRIN1	CESC	chr11	34101277	34101277	C	G	Nonsense_Mutation	p.S264*	1
CAPRIN1	BLCA	chr11	34097867	34097867	G	A	Missense_Mutation	p.E151K	1
CAPRIN1	COAD	chr11	34107698	34107698	C	G	Missense_Mutation	p.P352A	1
CAPRIN1	LIHC	chr11	34112090	34112090	A	-	Frame_Shift_Del	p.L473fs	1
CAPRIN1	SKCM	chr11	34097853	34097853	T	G	Nonsense_Mutation	p.L146*	1
CAPRIN1	HNSC	chr11	34074029	34074029	C	T	Missense_Mutation		1
CAPRIN1	LUAD	chr11	34097814	34097814	G	C	Missense_Mutation	p.R133P	1
CAPRIN1	LIHC	chr11	34098116	34098116	A	G	Silent		1
CAPRIN1	READ	chr11	34101238	34101238	A	G	Missense_Mutation	p.N251S	1
CAPRIN1	UCEC	chr11	34097864	34097864	C	T	Missense_Mutation	p.L150F	1
CAPRIN1	BLCA	chr11	34097866	34097866	T	C	Silent		1
CAPRIN1	CESC	chr11	34117896	34117896	C	T	RNA	NULL	1
CAPRIN1	BLCA	chr11	34118751	34118751	G	A	Missense_Mutation	p.D637N	1
CAPRIN1	COAD	chr11	34111793	34111793	C	G	Missense_Mutation	p.A454G	1
CAPRIN1	LIHC	chr11	34093293	34093293	G	-	Frame_Shift_Del	p.Q79fs	1
CAPRIN1	SKCM	chr11	34097853	34097853	T	G	Nonsense_Mutation	p.L146X	1
CAPRIN1	SKCM	chr11	34107888	34107888	C	T	Missense_Mutation	p.P387S	1
CAPRIN1	STAD	chr11	34098105	34098105	A	C	Splice_Site	p.R202_splice	1
CAPRIN1	HNSC	chr11	34074146	34074146	T	C	Missense_Mutation		1
CAPRIN1	LUAD	chr11	34104422	34104422	G	A	Missense_Mutation	p.E293K	1
CAPRIN1	LIHC	chr11	34110998	34110998	A	G	Missense_Mutation		1
CAPRIN1	READ	chr11	34104523	34104523	G	A	Missense_Mutation	p.A301T	1
CAPRIN1	BLCA	chr11	34097867	34097867	G	A	Missense_Mutation		1
CAPRIN1	CESC	chr11	34121474	34121474	C	T	RNA	NULL	1
CAPRIN1	BLCA	chr11	34113464	34113464	G	A	Missense_Mutation	p.M522I	1
CAPRIN1	COAD	chr11	34111796	34111796	C	T	Missense_Mutation	p.T455I	1
CAPRIN1	LIHC	chr11	34104414	34104414	A	-	Frame_Shift_Del	p.E290fs	1
CAPRIN1	SKCM	chr11	34093290	34093290	C	T	Silent	p.Y78Y	1
CAPRIN1	STAD	chr11	34097811	34097811	G	A	Missense_Mutation		1
CAPRIN1	LUAD	chr11	34118027	34118027	G	T	Silent	p.V569V	1
CAPRIN1	CESC	chr11	34119297	34119297	G	A	Missense_Mutation	p.G685E	1
CAPRIN1	SARC	chr11	34111815	34111815	G	T	Missense_Mutation		1
CAPRIN1	BLCA	chr11	34118751	34118751	G	A	Missense_Mutation		1
CAPRIN1	COAD	chr11	34118143	34118143	G	A	Missense_Mutation	p.R608H	1
CAPRIN1	LUAD	chr11	34118203	34118203	C	G	Missense_Mutation	p.P628R	1
CAPRIN1	SKCM	chr11	34074001	34074001	A	G	Missense_Mutation	p.S12G	1
CAPRIN1	UCS	chr11	34093499	34093499	G	T	Nonsense_Mutation	p.E111X	1
CAPRIN1	THCA	chr11	34093489	34093489	G	A	Silent		1
CAPRIN1	HNSC	chr11	34074146	34074146	T	C	Missense_Mutation	p.V60A	1
CAPRIN1	LUSC	chr11	34113458	34113458	C	A	Missense_Mutation	p.F520L	1
CAPRIN1	BLCA	chr11	34113464	34113464	G	A	Missense_Mutation		1
CAPRIN1	CESC	chr11	34120902	34120902	G	A	Silent	p.Q706	1
CAPRIN1	SARC	chr11	34097869	34097869	G	T	Missense_Mutation		1
CAPRIN1	BLCA	chr11	34118842	34118842	G	A	Splice_Site	p.R667Q	1
CAPRIN1	COAD	chr11	34101276	34101276	T	C	Missense_Mutation	p.S264P	1
CAPRIN1	LUAD	chr11	34113552	34113552	C	T	Nonsense_Mutation	p.Q552*	1
CAPRIN1	SKCM	chr11	34118054	34118054	C	T	Silent	p.D578D	1
CAPRIN1	THCA	chr11	34093489	34093489	G	A	Silent	p.E107E	1
CAPRIN1	HNSC	chr11	34074029	34074029	C	T	Missense_Mutation	p.S21L	1
CAPRIN1	OV	chr11	34098146	34098146	G	T	Missense_Mutation	p.W215C	1
CAPRIN1	BLCA	chr11	34110948	34110948	C	G	Missense_Mutation		1
CAPRIN1	CHOL	chr11	34074142	34074142	G	T	Missense_Mutation		1
CAPRIN1	LIHC	chr11	34112151	34112151	C	T	Nonsense_Mutation	p.Q494X	1
CAPRIN1	SARC	chr11	34093278	34093278	G	T	Missense_Mutation		1
CAPRIN1	SKCM	chr11	34104504	34104504	T	G	Nonsense_Mutation	p.Y294X	1
CAPRIN1	BLCA	chr11	34107638	34107638	C	T	Nonsense_Mutation	p.Q332*	1
CAPRIN1	COAD	chr11	34120852	34120852	C	T	Missense_Mutation	p.R690C	1
CAPRIN1	SKCM	chr11	34118216	34118216	C	T	Silent	p.F632F	1
CAPRIN1	THYM	chr11	34118803	34118803	C	A	Missense_Mutation		1
CAPRIN1	KICH	chr11	34074126	34074126	C	T	Silent	p.A53A	1
CAPRIN1	PAAD	chr11	34107957	34107957	C	G	Missense_Mutation		1
CAPRIN1	BLCA	chr11	34107919	34107919	C	A	Missense_Mutation		1
CAPRIN1	CHOL	chr11	34074072	34074072	C	T	Silent		1
CAPRIN1	SARC	chr11	34093332	34093332	G	T	Missense_Mutation		1
CAPRIN1	BLCA	chr11	34101183	34101183	C	G	Missense_Mutation	p.L233V	1
CAPRIN1	ESCA	chr11	34119305	34119305	C	T	Nonsense_Mutation	p.R688X	1
CAPRIN1	CESC	chr11	34101277	34101277	C	G	Missense_Mutation		1
CAPRIN1	KICH	chr11	34118204	34118204	T	-	Frame_Shift_Del	p.P628fs	1
CAPRIN1	BLCA	chr11	34101183	34101183	C	G	Missense_Mutation		1
CAPRIN1	SARC	chr11	34093493	34093493	G	T	Missense_Mutation		1
CAPRIN1	SKCM	chr11	34112119	34112119	C	T	Missense_Mutation	p.S483F	1
CAPRIN1	BLCA	chr11	34104565	34104565	G	C	Missense_Mutation	p.E315Q	1
CAPRIN1	ESCA	chr11	34098007	34098007	G	A	Silent	p.R197	1
CAPRIN1	LUAD	chr11	34118167	34118167	G	A	Missense_Mutation	p.R616H	1
CAPRIN1	THYM	chr11	34118803	34118803	C	A	Missense_Mutation	p.S654Y	1
CAPRIN1	CESC	chr11	34074229	34074229	C	G	RNA	NULL	1
CAPRIN1	KIRP	chr11	34118208	34118208	A	T	Missense_Mutation	p.N630Y	1
CAPRIN1	BLCA	chr11	34104565	34104565	G	C	Missense_Mutation		1
CAPRIN1	LIHC	chr11	34107939	34107939	C	-	Frame_Shift_Del	p.P404fs	1
CAPRIN1	SARC	chr11	34101309	34101309	G	T	Missense_Mutation		1
CAPRIN1	SKCM	chr11	34118810	34118810	C	T	Silent	p.F656F	1
CAPRIN1	BLCA	chr11	34097786	34097786	C	T	Nonsense_Mutation	p.Q124*	1
CAPRIN1	ESCA	chr11	34119305	34119305	C	T	Nonsense_Mutation		1
CAPRIN1	LUAD	chr11	34093306	34093306	A	G	Missense_Mutation	p.K84E	1
CAPRIN1	PRAD	chr11	34107948	34107948	G	A	Missense_Mutation	p.V407I	1
CAPRIN1	ACC	chr11	34104425	34104425	G	T	Splice_Site		1
CAPRIN1	CESC	chr11	34097786	34097786	C	G	Missense_Mutation	p.Q124E	1
CAPRIN1	LIHC	chr11	34093495	34093495	A	-	Frame_Shift_Del	p.A109fs	1
CAPRIN1	SARC	chr11	34107908	34107908	G	T	Missense_Mutation		1
CAPRIN1	SKCM	chr11	34097953	34097953	C	T	Silent	p.S179S	1
CAPRIN1	STAD	chr11	34098105	34098105	A	C	Splice_Site	.	1
CAPRIN1	BLCA	chr11	34097866	34097867	TG	CA	Missense_Mutation	p.E151K	1
CAPRIN1	LUAD	chr11	34097944	34097944	A	G	Silent	p.P176P	1
CAPRIN1	KIRP	chr11	34118752	34118752	A	G	Missense_Mutation		1
CAPRIN1	READ	chr11	34113541	34113541	G	T	Missense_Mutation	p.S548I	1
CAPRIN1	THYM	chr11	34074142	34074142	G	T	Missense_Mutation	p.G59W	1
CAPRIN1	ACC	chr11	34097794	34097795	AA	-	Frame_Shift_Del	p.TI126fs	1
CAPRIN1	CESC	chr11	34097834	34097834	G	C	Missense_Mutation	p.E140Q	1

Copy number variation (CNV) of CAPRIN1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CAPRIN1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
71295	BRCA	TCGA-A8-A07R-01A	ABCC8	chr11	17439844	-	CAPRIN1	chr11	34113602	-
71295	.	.	ARHGAP32	chr11	128993340	-	CAPRIN1	chr11	34093271	+
71295	.	.	ARHGAP32	chr11	128993341	-	CAPRIN1	chr11	34093271	+
84909	N/A	BF932122	CAPRIN1	chr11	34098172	+	ARHGAP17	chr16	24966041	-
74056	LGG	TCGA-DU-A7T6-01A	CAPRIN1	chr11	34113603	+	C11orf84	chr11	63585277	+
71295	N/A	BQ215232	CAPRIN1	chr11	34122200	-	CAPRIN1	chr11	34122240	+
91137	BRCA	TCGA-AC-A2BK	CAPRIN1	chr11	34093534	+	CAT	chr11	34470738	+
91137	BRCA	TCGA-AC-A2BK-01A	CAPRIN1	chr11	34093534	+	CAT	chr11	34470739	+
94765	ACC	TCGA-OR-A5J8-01A	CAPRIN1	chr11	34112225	+	CD151	chr11	838133	+
18552	BRCA	TCGA-BH-A0E2-01A	CAPRIN1	chr11	34104588	+	COMMD9	chr11	36297790	-
91021	N/A	BI856296	CAPRIN1	chr11	34122704	+	LEKR1	chr3	156647341	-
97617	GBM	TCGA-12-0619	CAPRIN1	chr11	34074183	+	RNF216	chr7	5681007	-
97617	GBM	TCGA-12-0619-01A	CAPRIN1	chr11	34074186	+	RNF216	chr7	5681005	-
97497	UCEC	TCGA-EO-A3KU-01A	CAPRIN1	chr11	34074586	+	THOC1	chr18	224994	-
94118	LUAD	TCGA-J2-A4AD-01A	CAPRIN1	chr11	34074183	+	TRIM44	chr11	35827908	+
99758	N/A	BF342119	CAPRIN1	chr11	34122051	+	XRCC4	chr5	82508744	+
71295	UCS	TCGA-N5-A4RO-01A	CD44	chr11	35160917	+	CAPRIN1	chr11	34110942	+
71295	UCS	TCGA-NG-A4VU	CD44	chr11	35160917	+	CAPRIN1	chr11	34110941	+
71295	UCS	TCGA-NG-A4VU-01A	CD44	chr11	35160916	+	CAPRIN1	chr11	34110941	+
71295	STAD	TCGA-BR-8058-01A	EPCAM	chr2	47604216	+	CAPRIN1	chr11	34107611	+
71295	N/A	AI420097	HDAC8	chrX	71760816	+	CAPRIN1	chr11	34120603	-
71295	N/A	AA662396	LEKR1	chr3	156647341	+	CAPRIN1	chr11	34122704	-
71295	BRCA	TCGA-AN-A0XU-01A	NAT10	chr11	34130380	+	CAPRIN1	chr11	34118026	+
71295	OV	TCGA-13-1501-01A	NAT10	chr11	34127339	+	CAPRIN1	chr11	34118026	+
71295	N/A	AI094846	NUP210L	chr1	154035516	+	CAPRIN1	chr11	34120607	-
71295	N/A	DN912506	PIAS2	chr18	44410383	-	CAPRIN1	chr11	34121270	+
71297	N/A	DA398472	RAB30-AS1	chr11	82783749	+	CAPRIN1	chr11	34093273	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	CAPRIN1	0.000617567382520879	0.017
KIRP	CAPRIN1	0.00187572043382329	0.051
READ	CAPRIN1	0.00627094622986783	0.16
SARC	CAPRIN1	0.0253160473592483	0.63
SKCM	CAPRIN1	0.049097812217032	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	CAPRIN1	0.00190395131909213	0.063
SKCM	CAPRIN1	0.0485973535932112	1
ESCA	CAPRIN1	0.00711288079009078	0.23

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source