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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DRG1 (NCBI Gene ID:4733)

Gene Summary

Gene Summary

Gene Information	Gene Name: DRG1
	Gene ID: 4733
	Gene Symbol	DRG1
	Gene ID	4733
	Gene Name	developmentally regulated GTP binding protein 1
	Synonyms	NEDD3
	Cytomap	22q12.2
	Type of Gene	protein-coding
	Description	developmentally-regulated GTP-binding protein 1DRG-1NEDD-3TRAFAC GTPase DRG1neural precursor cell expressed developmentally down-regulated protein 3neural precursor cell expressed, developmentally down-regulated 3translation factor GTPase DRG1
	Modification date	20200313
	UniProtAcc	Q9Y295

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'DRG1[title] AND translation [title] AND human.'

Gene	Title	PMID
DRG1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000331457	31799014	31799190	Frame-shift
ENST00000331457	31806997	31807067	Frame-shift
ENST00000331457	31816241	31816411	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	DRG1	-1.38896782665224	0.00022838170846318
KIRC	DRG1	-4.16008421708878	0.0152218459760014
CHOL	DRG1	-2.74036943476079	0.01953125

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRP	DRG1	-0.055599163	0.013678164

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DRG1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	DRG1	SUCLG1	0.800538102	8.53E-12
DLBC	Cell metabolism gene	DRG1	TIMM10	0.800590425	8.48E-12
DLBC	Cell metabolism gene	DRG1	MDH2	0.802935663	6.64E-12
DLBC	Cell metabolism gene	DRG1	ATP5G1	0.803212867	6.45E-12
DLBC	Cell metabolism gene	DRG1	EXOSC4	0.806471545	4.56E-12
DLBC	Cell metabolism gene	DRG1	SNRPD2	0.809737496	3.20E-12
DLBC	Cell metabolism gene	DRG1	PSMB3	0.812591209	2.34E-12
DLBC	Cell metabolism gene	DRG1	PSMD8	0.81590855	1.61E-12
DLBC	Cell metabolism gene	DRG1	MIF	0.817300206	1.37E-12
DLBC	Cell metabolism gene	DRG1	POLR2F	0.831019226	2.67E-13
DLBC	Cell metabolism gene	DRG1	TIMM13	0.832668746	2.17E-13
DLBC	Cell metabolism gene	DRG1	SNRPE	0.836535499	1.33E-13
DLBC	Cell metabolism gene	DRG1	DTYMK	0.855809132	9.21E-15
DLBC	Cell metabolism gene	DRG1	SNRPB	0.857532438	7.12E-15
DLBC	Cell metabolism gene	DRG1	TOMM22	0.861988309	3.61E-15
DLBC	Cell metabolism gene	DRG1	PSMC3	0.864021564	2.62E-15
DLBC	Cell metabolism gene	DRG1	ADSL	0.8697603	1.04E-15
DLBC	Cell metabolism gene	DRG1	SNRPD3	0.877821154	2.61E-16
DLBC	Cell metabolism gene	DRG1	SAMM50	0.881595256	1.32E-16
DLBC	Cell metabolism gene	DRG1	TIMM50	0.886166607	5.63E-17
DLBC	CGC	DRG1	U2AF1	0.817508075	1.34E-12
DLBC	Epifactor	DRG1	EXOSC4	0.806471545	4.56E-12
DLBC	Epifactor	DRG1	RRP8	0.81266552	2.32E-12
DLBC	Epifactor	DRG1	RUVBL2	0.856827588	7.92E-15
DLBC	IUPHAR	DRG1	MFSD2B	0.8176661	1.32E-12
DLBC	IUPHAR	DRG1	BIRC5	0.854050825	1.19E-14
DLBC	TSG	DRG1	GADD45GIP1	0.834207964	1.79E-13
DLBC	TSG	DRG1	PHB	0.859278919	5.47E-15
ESCA	Cell metabolism gene	DRG1	SNRPD3	0.812335972	2.59E-47
GBM	Cell metabolism gene	DRG1	HSCB	0.801240233	9.17E-40
GBM	Cell metabolism gene	DRG1	ADSL	0.859054913	2.57E-51
GBM	Cell metabolism gene	DRG1	TOMM22	0.882003116	1.96E-57
GBM	Epifactor	DRG1	RBX1	0.838158336	1.28E-46
KIRP	Cell metabolism gene	DRG1	TOMM22	0.822810558	9.03E-81
LGG	Cell metabolism gene	DRG1	TOMM22	0.814744294	4.45E-127
LUSC	Cell metabolism gene	DRG1	ADSL	0.806818973	4.87E-128
LUSC	Cell metabolism gene	DRG1	TOMM22	0.823576952	8.43E-138
MESO	Cell metabolism gene	DRG1	POLR2F	0.806071623	4.60E-21
MESO	Cell metabolism gene	DRG1	TOMM22	0.812817019	1.19E-21
PRAD	Cell metabolism gene	DRG1	TOMM22	0.803037438	2.71E-125
READ	Cell metabolism gene	DRG1	SNRPD3	0.802508814	7.69E-25
READ	Cell metabolism gene	DRG1	POLR2F	0.810236393	1.22E-25
READ	Cell metabolism gene	DRG1	TOMM22	0.856232236	2.60E-31
TGCT	Cell metabolism gene	DRG1	TUBA1C	0.824733178	5.85E-40
TGCT	Cell metabolism gene	DRG1	NOP56	0.829758902	7.65E-41
TGCT	Cell metabolism gene	DRG1	ADSL	0.863286091	1.38E-47
TGCT	Cell metabolism gene	DRG1	TOMM22	0.865700333	3.85E-48
TGCT	Epifactor	DRG1	TRIM28	0.810502733	1.33E-37
TGCT	IUPHAR	DRG1	TRIM28	0.810502733	1.33E-37
TGCT	Kinase	DRG1	TRIM28	0.810502733	1.33E-37
TGCT	TF	DRG1	MYBL2	0.819571559	4.42E-39
THYM	Cell metabolism gene	DRG1	SNRPB	0.800195161	2.05E-28
THYM	Cell metabolism gene	DRG1	LSM3	0.800274445	2.01E-28
THYM	Cell metabolism gene	DRG1	SLC27A5	0.803762601	7.80E-29
THYM	Cell metabolism gene	DRG1	IDH3B	0.813521569	4.99E-30
THYM	Cell metabolism gene	DRG1	LSM2	0.821991893	4.02E-31
THYM	Cell metabolism gene	DRG1	ACOT8	0.823805923	2.30E-31
THYM	Cell metabolism gene	DRG1	PSMB7	0.829084538	4.39E-32
THYM	Cell metabolism gene	DRG1	PSMC3	0.830263221	3.01E-32
THYM	Cell metabolism gene	DRG1	GCDH	0.830779849	2.54E-32
THYM	Cell metabolism gene	DRG1	TIMM13	0.840583979	9.65E-34
THYM	Cell metabolism gene	DRG1	POLR2F	0.842302062	5.32E-34
THYM	Cell metabolism gene	DRG1	SNRPD2	0.842494726	4.97E-34
THYM	Cell metabolism gene	DRG1	SNRPD3	0.85233872	1.41E-35
THYM	Cell metabolism gene	DRG1	POLD2	0.856549347	2.83E-36
THYM	Cell metabolism gene	DRG1	TOMM22	0.874192332	1.86E-39
THYM	CGC	DRG1	RBM10	0.803475904	8.44E-29
THYM	CGC	DRG1	TFPT	0.845863555	1.51E-34
THYM	Epifactor	DRG1	TRIM28	0.804210995	6.90E-29
THYM	Epifactor	DRG1	FBL	0.806645828	3.52E-29
THYM	Epifactor	DRG1	PAF1	0.818124599	1.29E-30
THYM	Epifactor	DRG1	PRPF31	0.818298664	1.23E-30
THYM	Epifactor	DRG1	RUVBL2	0.832044098	1.69E-32
THYM	Epifactor	DRG1	TFPT	0.845863555	1.51E-34
THYM	IUPHAR	DRG1	SLC27A5	0.803762601	7.80E-29
THYM	IUPHAR	DRG1	TRIM28	0.804210995	6.90E-29
THYM	IUPHAR	DRG1	PPIA	0.809208515	1.72E-29
THYM	Kinase	DRG1	TRIM28	0.804210995	6.90E-29
THYM	TF	DRG1	ZNF428	0.807461471	2.80E-29
THYM	TF	DRG1	THYN1	0.812119679	7.48E-30
THYM	TF	DRG1	PIN1	0.818700106	1.09E-30
THYM	TSG	DRG1	PIN1	0.818700106	1.09E-30
THYM	TSG	DRG1	GNB2L1	0.854505014	6.21E-36
UCS	Cell metabolism gene	DRG1	SNRPB	0.800195161	2.05E-28
UCS	Cell metabolism gene	DRG1	LSM3	0.800274445	2.01E-28
UCS	Cell metabolism gene	DRG1	SLC27A5	0.803762601	7.80E-29
UCS	Cell metabolism gene	DRG1	IDH3B	0.813521569	4.99E-30
UCS	Cell metabolism gene	DRG1	LSM2	0.821991893	4.02E-31
UCS	Cell metabolism gene	DRG1	ACOT8	0.823805923	2.30E-31
UCS	Cell metabolism gene	DRG1	PSMB7	0.829084538	4.39E-32
UCS	Cell metabolism gene	DRG1	PSMC3	0.830263221	3.01E-32
UCS	Cell metabolism gene	DRG1	GCDH	0.830779849	2.54E-32
UCS	Cell metabolism gene	DRG1	TIMM13	0.840583979	9.65E-34
UCS	Cell metabolism gene	DRG1	POLR2F	0.842302062	5.32E-34
UCS	Cell metabolism gene	DRG1	SNRPD2	0.842494726	4.97E-34
UCS	Cell metabolism gene	DRG1	SNRPD3	0.85233872	1.41E-35
UCS	Cell metabolism gene	DRG1	POLD2	0.856549347	2.83E-36
UCS	Cell metabolism gene	DRG1	TOMM22	0.874192332	1.86E-39
UCS	CGC	DRG1	RBM10	0.803475904	8.44E-29
UCS	CGC	DRG1	TFPT	0.845863555	1.51E-34
UCS	Epifactor	DRG1	TRIM28	0.804210995	6.90E-29
UCS	Epifactor	DRG1	FBL	0.806645828	3.52E-29
UCS	Epifactor	DRG1	PAF1	0.818124599	1.29E-30
UCS	Epifactor	DRG1	PRPF31	0.818298664	1.23E-30
UCS	Epifactor	DRG1	RUVBL2	0.832044098	1.69E-32
UCS	Epifactor	DRG1	TFPT	0.845863555	1.51E-34
UCS	IUPHAR	DRG1	SLC27A5	0.803762601	7.80E-29
UCS	IUPHAR	DRG1	TRIM28	0.804210995	6.90E-29
UCS	IUPHAR	DRG1	PPIA	0.809208515	1.72E-29
UCS	Kinase	DRG1	TRIM28	0.804210995	6.90E-29
UCS	TF	DRG1	ZNF428	0.807461471	2.80E-29
UCS	TF	DRG1	THYN1	0.812119679	7.48E-30
UCS	TF	DRG1	PIN1	0.818700106	1.09E-30
UCS	TSG	DRG1	PIN1	0.818700106	1.09E-30
UCS	TSG	DRG1	GNB2L1	0.854505014	6.21E-36

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	DRG1	QARS	-4.19270554058168	0.00045278023754438
KICH	DRG1	WDR12	1.27437010311891	0.000631332397460937
BRCA	DRG1	ABCE1	1.3740626146648	0.000669229587514616
ESCA	DRG1	BRIX1	-3.68972417085688	0.0009765625
KIRP	DRG1	POLR2E	1.23265401096991	0.00143672106787562
THCA	DRG1	QARS	-1.4601543520666	0.00171161769998529
ESCA	DRG1	WDR12	-4.50085604434153	0.001953125
LIHC	DRG1	ABCE1	1.33775121002715	0.0033398145023608
CHOL	DRG1	POLR2E	-5.34523892600449	0.00390625
STAD	DRG1	ZC3H15	-1.04968618173197	0.00733334058895707
ESCA	DRG1	RWDD1	1.43074573953025	0.009765625
HNSC	DRG1	ABCE1	1.20332081233659	0.0124875666290336
BLCA	DRG1	ABCE1	-4.08863120087471	0.0229873657226562
BLCA	DRG1	ZC3H15	1.07480871713981	0.0258216857910156
PRAD	DRG1	RWDD1	-1.37015889011473	0.0291755363147523
KICH	DRG1	POLR2E	2.04319971062501	1.23381614685059e-05
PRAD	DRG1	ABCE1	-2.9089513514626	1.31460603050763e-05
LIHC	DRG1	WDR12	-3.16467679630325	2.54824448841554e-08
BRCA	DRG1	POLR2E	1.06411979989366	2.7227965426238e-05
BRCA	DRG1	RWDD1	-1.13785288766259	3.18183978181012e-05
PRAD	DRG1	QARS	1.84374784424986	3.33417295851411e-06
STAD	DRG1	WDR12	-2.46721337744962	6.79492950439454e-06
STAD	DRG1	BRIX1	-4.28173420731282	7.8696757555008e-08
KIRC	DRG1	POLR2E	-2.38370423485223	8.04051937698217e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DRG1

RWDD1, CAPNS1, HDGF, ZC3H15, UBE2I, GRB2, TAL1, BARD1, BRCA1, PAXIP1, VCAM1, FN1, ITGA4, CLDN1, SRPK2, HECW2, WWOX, PHKG2, STAU1, PHC2, SKIL, COIL, STK16, SSX2IP, CUL7, CCDC8, ABL1, MAST3, LRRC41, NTMT1, HAO1, CAND1, CAND2, FEN1, IFRD2, KIF23, NAA15, SFN, NTRK1, XPO1, RPL10, Rpl35, Rrbp1, SNW1, CDC5L, OSCP1, COPZ1, SARNP, SUB1, CHORDC1, DIS3, ZC3HAV1, SEPT7, PRCC, CDK5, SH3GLB1, CYLD, MTF1, BRD1, TRIM14, EGLN3, EFTUD2, RIOK1, ESR2, HEXIM1, MEPCE, LARP7, RECQL4, Prkaa1, Prkab1, ATG16L1, PHB, KRAS, NR2C2, SNRNP70, BIRC3, LMBR1L, NFX1, BRD7, LNX1, MEOX2, PLEKHA4, PTEN, HCVgp1, RASA1, N, nsp8, ESR1, CIT, KIF14, RNF11, Apc2, IFI16, CUL4A, DNAJC2, RPL10A, HSPA14, RPL4, RPL6, RPL7, RPL7A, RPL8, RPL18, RPLP0, TCEB1, TCEB2, DNAJC1, ACADSB, MKRN1, SPOP, UFL1, DDRGK1, AIFM1, AKAP1, ANAPC2, CLIP1, CXADR, DHFRL1, KRT19, LAMTOR1, LCK, POLR2C, PRPH, SQSTM1, FZR1, WDR5, SOSTDC1, ACTA2, EP300, FBXW7, SIRT6,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DRG1	chr22	31796605	G	T	single_nucleotide_variant	Uncertain_significance	Neurodevelopmental_disorder	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
DRG1	chr22	31796681	C	T	single_nucleotide_variant	Likely_pathogenic	Flexion_contracture	SO:0001587\|nonsense	SO:0001587\|nonsense

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DRG1	BLCA	chr22	31822619	31822619	C	G	Missense_Mutation	p.I244M	5
DRG1	BRCA	chr22	31819322	31819322	G	C	Missense_Mutation	p.K213N	3
DRG1	UCS	chr22	31829935	31829935	T	C	Missense_Mutation	p.V361A	3
DRG1	SKCM	chr22	31807018	31807018	C	T	Silent	p.I121I	3
DRG1	UVM	chr22	31816310	31816310	A	G	Missense_Mutation	p.I161V	3
DRG1	BLCA	chr22	31796663	31796663	C	T	Missense_Mutation	p.R34C	2
DRG1	STAD	chr22	31822649	31822649	C	T	Silent		2
DRG1	UCEC	chr22	31799045	31799045	G	A	Missense_Mutation	p.R66Q	2
DRG1	UCEC	chr22	31807065	31807065	C	T	Missense_Mutation	p.A137V	2
DRG1	STAD	chr22	31822649	31822649	C	T	Silent	p.S254S	2
DRG1	UCEC	chr22	31816248	31816248	G	A	Missense_Mutation	p.R140Q	2
DRG1	UCEC	chr22	31816303	31816303	G	T	Missense_Mutation	p.K158N	2
DRG1	STAD	chr22	31823111	31823111	C	T	Missense_Mutation	p.T316I	2
DRG1	UCEC	chr22	31816306	31816306	G	A	Silent	p.K159	2
DRG1	CESC	chr22	31823084	31823084	C	T	Missense_Mutation		2
DRG1	STAD	chr22	31822637	31822637	T	C	Silent	p.I250I	2
DRG1	UCEC	chr22	31819288	31819288	C	T	Missense_Mutation	p.A202V	2
DRG1	UCEC	chr22	31819384	31819384	T	C	Missense_Mutation	p.V234A	2
DRG1	CESC	chr22	31823084	31823084	C	T	Missense_Mutation	p.S307F	2
DRG1	LIHC	chr22	31799026	31799026	G	T	Missense_Mutation	p.A60S	2
DRG1	LIHC	chr22	31816314	31816314	A	-	Frame_Shift_Del	p.E162fs	2
DRG1	SKCM	chr22	31829903	31829903	G	A	Silent	p.V350V	2
DRG1	BLCA	chr22	31816285	31816285	G	A	Silent	p.L152L	2
DRG1	UVM	chr22	31816310	31816310	A	G	Missense_Mutation		2
DRG1	KIRP	chr22	31799189	31799189	A	G	Splice_Site	p.Q114_splice	2
DRG1	BLCA	chr22	31822752	31822752	C	G	Missense_Mutation	p.L289V	2
DRG1	LIHC	chr22	31822755	31822755	A	-	Frame_Shift_Del	p.K290fs	2
DRG1	KIRP	chr22	31799189	31799189	A	G	Missense_Mutation	p.Q114R	1
DRG1	UCEC	chr22	31819397	31819397	G	A	Splice_Site	p.R238_splice	1
DRG1	LIHC	chr22	31816331	31816331	T	-	Frame_Shift_Del	p.F168fs	1
DRG1	COAD	chr22	31816296	31816296	G	A	Missense_Mutation	p.G156E	1
DRG1	KIRP	chr22	31829876	31829876	C	A	Silent		1
DRG1	BLCA	chr22	31799166	31799166	C	G	Missense_Mutation	p.I106M	1
DRG1	LUAD	chr22	31823154	31823154	C	T	Silent	p.I330I	1
DRG1	COAD	chr22	31822711	31822711	G	A	Missense_Mutation	p.R275H	1
DRG1	LGG	chr22	31796608	31796608	G	T	Missense_Mutation	p.M15I	1
DRG1	LUSC	chr22	31829895	31829895	C	G	Missense_Mutation	p.Q348E	1
DRG1	ESCA	chr22	31795658	31795658	G	T	RNA	NULL	1
DRG1	STAD	chr22	31829850	31829859	CCATGCAGTG	-	Frame_Shift_Del	p.335_335del	1
DRG1	LGG	chr22	31796681	31796681	C	T	Nonsense_Mutation	p.R40*	1
DRG1	PAAD	chr22	31819348	31819348	G	A	Missense_Mutation	p.R222H	1
DRG1	ESCA	chr22	31799191	31799191	G	A	Splice_Site	e3+1	1
DRG1	BLCA	chr22	31816285	31816285	G	A	Silent		1
DRG1	LIHC	chr22	31799026	31799026	G	T	Missense_Mutation		1
DRG1	PRAD	chr22	31829930	31829930	G	T	Missense_Mutation	p.E359D	1
DRG1	ESCA	chr22	31799191	31799191	G	A	Splice_Site		1
DRG1	BLCA	chr22	31822752	31822752	C	G	Missense_Mutation		1
DRG1	LIHC	chr22	31822736	31822736	A	G	Silent		1
DRG1	CESC	chr22	31816296	31816296	G	T	Missense_Mutation		1
DRG1	READ	chr22	31799071	31799071	G	A	Missense_Mutation	p.V75M	1
DRG1	ESCA	chr22	31799191	31799191	G	A	Splice_Site	.	1
DRG1	STAD	chr22	31829850	31829859	CCATGCAGTG	-	Splice_Site	p.L336_splice	1
DRG1	BLCA	chr22	31796663	31796663	C	T	Missense_Mutation		1
DRG1	LIHC	chr22	31796695	31796695	T	C	Silent	p.T44T	1
DRG1	SARC	chr22	31816267	31816267	G	T	Missense_Mutation		1
DRG1	HNSC	chr22	31829860	31829860	C	A	Missense_Mutation		1
DRG1	THYM	chr22	31816350	31816350	G	A	Missense_Mutation	p.S174N	1
DRG1	BLCA	chr22	31799166	31799166	C	G	Missense_Mutation		1
DRG1	UCS	chr22	31829935	31829935	T	C	Missense_Mutation		1
DRG1	CESC	chr22	31819365	31819365	G	A	Missense_Mutation	p.D228N	1
DRG1	SARC	chr22	31799118	31799118	G	T	Missense_Mutation		1
DRG1	HNSC	chr22	31829860	31829860	C	A	Missense_Mutation	p.A336D	1
DRG1	THYM	chr22	31823063	31823063	G	T	Missense_Mutation	p.G300V	1
DRG1	BLCA	chr22	31822619	31822619	C	G	Missense_Mutation		1
DRG1	CESC	chr22	31819365	31819365	G	A	Missense_Mutation		1
DRG1	KIRP	chr22	31816283	31816283	C	T	Silent	p.L152L	1
DRG1	THYM	chr22	31823119	31823119	G	T	Nonsense_Mutation	p.E319X	1
DRG1	LIHC	chr22	31816245	31816245	C	-	Frame_Shift_Del	p.A139fs	1
DRG1	COAD	chr22	31799027	31799027	C	T	Missense_Mutation	p.A60V	1
DRG1	UCEC	chr22	31816283	31816283	C	A	Missense_Mutation	p.L152M	1
DRG1	COAD	chr22	31799098	31799098	C	A	Missense_Mutation	p.L84M	1
DRG1	STAD	chr22	31829850	31829859	CCATGCAGTG	-	Splice_Site		1

Copy number variation (CNV) of DRG1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DRG1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
91909	N/A	BM151065	ANKRD28	chr3	15891687	-	DRG1	chr22	31830172	-
91909	BRCA	TCGA-D8-A140-01A	DEPDC5	chr22	32215211	+	DRG1	chr22	31924676	+
100181	N/A	BM150997	DRG1	chr22	31829856	-	DEPDC5	chr22	32272251	-
102721	ESCA	TCGA-LN-A5U7	DRG1	chr22	31819396	+	LIMK2	chr22	31667122	+
102721	LGG	TCGA-CS-6666	DRG1	chr22	31904362	+	LIMK2	chr22	31654277	+
103282	GBM	TCGA-19-2625-01A	DRG1	chr22	31823168	+	MYH9	chr22	36723533	-
103175	LUSC	TCGA-33-4532	DRG1	chr22	31799190	+	MYO18B	chr22	26317223	+
103175	LUSC	TCGA-33-4532-01A	DRG1	chr22	31799189	+	MYO18B	chr22	26317223	+
103175	LUSC	TCGA-33-4532-01A	DRG1	chr22	31799190	+	MYO18B	chr22	26317224	+
50148	N/A	DB064896	DRG1	chr22	31799126	+	SZRD1	chr1	16719832	+
91909	N/A	BQ372668	INTS4	chr11	77629341	+	DRG1	chr22	31807696	-
91909	N/A	DN912858	MLLT3	chr9	20502104	+	DRG1	chr22	31820808	-
91909	N/A	BG032465	NDUFB7	chr19	14676890	-	DRG1	chr22	31828432	-
91909	OV	TCGA-24-1845	RELB	chr19	45515534	+	DRG1	chr22	31806997	+
91909	LUAD	TCGA-97-A4M3-01A	RMDN2	chr2	38156872	+	DRG1	chr22	31822601	+
91909	N/A	DL058742	TCOF1	chr5	149778004	+	DRG1	chr22	31439595	+
91912	N/A	BF813460	TMEM214	chr2	27262627	-	DRG1	chr22	31830006	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	DRG1	0.000987088321232784	0.028
TGCT	DRG1	0.0101500189048071	0.27
STAD	DRG1	0.0368268320128155	0.96

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
ESCA	DRG1	0.00200487722028485	0.066
THYM	DRG1	0.0167365594950762	0.52
SARC	DRG1	0.00650725149881043	0.21

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source