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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PA2G4 (NCBI Gene ID:5036)

Gene Summary

Gene Summary

Gene Information	Gene Name: PA2G4
	Gene ID: 5036
	Gene Symbol	PA2G4
	Gene ID	5036
	Gene Name	proliferation-associated 2G4
	Synonyms	EBP1\|HG4-1\|p38-2G4
	Cytomap	12q13.2
	Type of Gene	protein-coding
	Description	proliferation-associated protein 2G4ErbB-3 binding protein 1ErbB3-binding protein Ebp1cell cycle protein p38-2G4 homologerbB3-binding protein 1proliferation-associated 2G4, 38kDproliferation-associated 2G4, 38kDa
	Modification date	20200313
	UniProtAcc	Q9UQ80

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PA2G4	GO:0045892	negative regulation of transcription, DNA-templated	15073182

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'PA2G4[title] AND translation [title] AND human.'

Gene	Title	PMID
PA2G4	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000303305	56505259	56505313	In-frame

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	PA2G4	-1.39525821465227	0.000305145157975212
BRCA	PA2G4	-1.29091766707702	0.000664421590817696
LIHC	PA2G4	-2.11966355213965	1.52957264107439e-06
LUAD	PA2G4	-1.77916485674617	2.04592776341023e-07
KIRC	PA2G4	-1.18793742823904	2.15831756070263e-10
KIRP	PA2G4	-1.71581840025124	2.49594449996948e-07
STAD	PA2G4	-2.25448780422398	6.68526627123356e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
PCPG	PA2G4	hsa-miR-223-3p	73	-0.325827653359299	0.00353146501612761

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LIHC	PA2G4	2	1	0.0237395061418053	0.215880534488985	0.180041310541311	-0.646959035498517	-0.539436532890182
MESO	PA2G4	2	1	0.0108361377218407	0.206107878787879	0.178573245614035	0.517273273507291	0.141276503172518

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
READ	PA2G4	0.171431794	0.001392133
GBM	PA2G4	0.320554873	0.012450356

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PA2G4 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	PA2G4	HSPD1	0.801780342	4.27E-75
COAD	Cell metabolism gene	PA2G4	NME1	0.806106675	1.70E-76
COAD	Cell metabolism gene	PA2G4	NUP37	0.827023874	8.55E-84
COAD	Cell metabolism gene	PA2G4	CCT2	0.857649532	1.82E-96
COAD	Cell metabolism gene	PA2G4	SNRPF	0.863564051	2.95E-99
COAD	CGC	PA2G4	CDK4	0.830966101	2.79E-85
COAD	IUPHAR	PA2G4	CDK4	0.830966101	2.79E-85
COAD	Kinase	PA2G4	CDK4	0.830966101	2.79E-85
COAD	TSG	PA2G4	HSPD1	0.801780342	4.27E-75
COAD	TSG	PA2G4	NME1	0.806106675	1.70E-76
DLBC	Cell metabolism gene	PA2G4	EXOSC2	0.81438278	1.91E-12
DLBC	Cell metabolism gene	PA2G4	CCT2	0.822772771	7.27E-13
DLBC	Cell metabolism gene	PA2G4	NOP56	0.826515989	4.65E-13
DLBC	Epifactor	PA2G4	EXOSC2	0.81438278	1.91E-12
LAML	Cell metabolism gene	PA2G4	NME1	0.80308002	2.69E-40
LAML	CGC	PA2G4	CDK4	0.81864063	4.83E-43
LAML	IUPHAR	PA2G4	CDK4	0.81864063	4.83E-43
LAML	Kinase	PA2G4	CDK4	0.81864063	4.83E-43
LAML	TSG	PA2G4	NME1	0.80308002	2.69E-40
READ	Cell metabolism gene	PA2G4	SNRPF	0.846355544	6.11E-30
READ	CGC	PA2G4	CDK4	0.83179091	4.39E-28
READ	IUPHAR	PA2G4	CDK4	0.83179091	4.39E-28
READ	Kinase	PA2G4	CDK4	0.83179091	4.39E-28
TGCT	Cell metabolism gene	PA2G4	TUBA1C	0.80804611	3.23E-37
TGCT	Cell metabolism gene	PA2G4	NME1	0.815817503	1.85E-38
TGCT	Cell metabolism gene	PA2G4	TIMM44	0.821779431	1.88E-39
TGCT	Cell metabolism gene	PA2G4	TIMM50	0.827915661	1.63E-40
TGCT	Cell metabolism gene	PA2G4	SNRPD1	0.835546937	6.75E-42
TGCT	Cell metabolism gene	PA2G4	PFDN4	0.835662731	6.43E-42
TGCT	Cell metabolism gene	PA2G4	TOMM40	0.838719859	1.71E-42
TGCT	Cell metabolism gene	PA2G4	PSMC4	0.855341819	7.75E-46
TGCT	Cell metabolism gene	PA2G4	SNRPF	0.870833755	2.35E-49
TGCT	Epifactor	PA2G4	DNAJC2	0.80416329	1.29E-36
TGCT	IUPHAR	PA2G4	PPIA	0.803814565	1.46E-36
TGCT	TSG	PA2G4	NME1	0.815817503	1.85E-38
THYM	Cell metabolism gene	PA2G4	EXOSC5	0.801100574	1.61E-28
THYM	Cell metabolism gene	PA2G4	TIMM17B	0.802343189	1.15E-28
THYM	Cell metabolism gene	PA2G4	TKT	0.806143795	4.05E-29
THYM	Cell metabolism gene	PA2G4	PSME1	0.806218873	3.96E-29
THYM	Cell metabolism gene	PA2G4	SNRPG	0.808425117	2.14E-29
THYM	Cell metabolism gene	PA2G4	POLR2H	0.810084033	1.34E-29
THYM	Cell metabolism gene	PA2G4	GNA15	0.813168281	5.53E-30
THYM	Cell metabolism gene	PA2G4	ZNRD1	0.813880383	4.50E-30
THYM	Cell metabolism gene	PA2G4	TXN	0.818148887	1.28E-30
THYM	Cell metabolism gene	PA2G4	ANP32A	0.818619676	1.11E-30
THYM	Cell metabolism gene	PA2G4	SNRPE	0.819365456	8.90E-31
THYM	Cell metabolism gene	PA2G4	TIMM13	0.819689645	8.08E-31
THYM	Cell metabolism gene	PA2G4	DUT	0.820054159	7.24E-31
THYM	Cell metabolism gene	PA2G4	PHKG2	0.821825605	4.23E-31
THYM	Cell metabolism gene	PA2G4	POLD2	0.822703446	3.23E-31
THYM	Cell metabolism gene	PA2G4	NME1	0.823772194	2.33E-31
THYM	Cell metabolism gene	PA2G4	EXOSC1	0.824514303	1.85E-31
THYM	Cell metabolism gene	PA2G4	ACOT8	0.824935207	1.62E-31
THYM	Cell metabolism gene	PA2G4	LSM3	0.828534356	5.23E-32
THYM	Cell metabolism gene	PA2G4	POLD1	0.828993822	4.52E-32
THYM	Cell metabolism gene	PA2G4	PSMA5	0.829776997	3.51E-32
THYM	Cell metabolism gene	PA2G4	GALK1	0.835762961	4.96E-33
THYM	Cell metabolism gene	PA2G4	PGP	0.836528098	3.84E-33
THYM	Cell metabolism gene	PA2G4	EBP	0.838687751	1.85E-33
THYM	Cell metabolism gene	PA2G4	PSMB7	0.843138988	3.97E-34
THYM	Cell metabolism gene	PA2G4	PSMA6	0.84516514	1.94E-34
THYM	Cell metabolism gene	PA2G4	DGUOK	0.850763333	2.53E-35
THYM	Cell metabolism gene	PA2G4	POLA2	0.852322735	1.42E-35
THYM	Cell metabolism gene	PA2G4	TOMM40	0.852426222	1.36E-35
THYM	Cell metabolism gene	PA2G4	LSM5	0.852761309	1.20E-35
THYM	Cell metabolism gene	PA2G4	TUBA1C	0.858479797	1.33E-36
THYM	Cell metabolism gene	PA2G4	GEMIN6	0.859829703	7.83E-37
THYM	Cell metabolism gene	PA2G4	LSM2	0.860520394	5.95E-37
THYM	Cell metabolism gene	PA2G4	TIMM8B	0.860889474	5.13E-37
THYM	Cell metabolism gene	PA2G4	PAFAH1B3	0.864484328	1.19E-37
THYM	Cell metabolism gene	PA2G4	SNRPD2	0.864610423	1.13E-37
THYM	Cell metabolism gene	PA2G4	TK1	0.868018851	2.72E-38
THYM	Cell metabolism gene	PA2G4	NOP56	0.868610065	2.12E-38
THYM	Cell metabolism gene	PA2G4	PSMB3	0.874850074	1.39E-39
THYM	Cell metabolism gene	PA2G4	POLR3K	0.877372814	4.42E-40
THYM	Cell metabolism gene	PA2G4	PSMC3	0.879268797	1.84E-40
THYM	Cell metabolism gene	PA2G4	PSMD13	0.88343785	2.54E-41
THYM	Cell metabolism gene	PA2G4	SNRPB	0.885959599	7.39E-42
THYM	Cell metabolism gene	PA2G4	PSMA4	0.888364626	2.21E-42
THYM	Cell metabolism gene	PA2G4	SNRPF	0.896567302	2.92E-44
THYM	Cell metabolism gene	PA2G4	LSM4	0.901325394	2.00E-45
THYM	Cell metabolism gene	PA2G4	AAAS	0.904364208	3.36E-46
THYM	Cell metabolism gene	PA2G4	DTYMK	0.906120286	1.17E-46
THYM	Cell metabolism gene	PA2G4	SNRPD1	0.926239878	1.11E-52
THYM	CGC	PA2G4	FANCG	0.804336421	6.66E-29
THYM	CGC	PA2G4	CDK4	0.806567297	3.60E-29
THYM	CGC	PA2G4	TFPT	0.812651051	6.42E-30
THYM	CGC	PA2G4	POLD1	0.828993822	4.52E-32
THYM	CGC	PA2G4	FEN1	0.834098405	8.61E-33
THYM	CGC	PA2G4	RECQL4	0.837531967	2.74E-33
THYM	CGC	PA2G4	SDHAF2	0.845491748	1.72E-34
THYM	Epifactor	PA2G4	EXOSC5	0.801100574	1.61E-28
THYM	Epifactor	PA2G4	SS18L2	0.801333636	1.51E-28
THYM	Epifactor	PA2G4	NOC2L	0.8028747	9.94E-29
THYM	Epifactor	PA2G4	HIST1H3F	0.80379747	7.73E-29
THYM	Epifactor	PA2G4	SIRT6	0.808242108	2.25E-29
THYM	Epifactor	PA2G4	INO80C	0.811317999	9.42E-30
THYM	Epifactor	PA2G4	TFPT	0.812651051	6.42E-30
THYM	Epifactor	PA2G4	HIST1H2AJ	0.817509842	1.55E-30
THYM	Epifactor	PA2G4	ANP32A	0.818619676	1.11E-30
THYM	Epifactor	PA2G4	AURKB	0.819160827	9.47E-31
THYM	Epifactor	PA2G4	SIRT7	0.823026572	2.93E-31
THYM	Epifactor	PA2G4	EXOSC1	0.824514303	1.85E-31
THYM	Epifactor	PA2G4	CXXC1	0.828849308	4.73E-32
THYM	Epifactor	PA2G4	BRMS1	0.837095786	3.17E-33
THYM	Epifactor	PA2G4	TAF10	0.837963087	2.36E-33
THYM	Epifactor	PA2G4	SUV39H1	0.845554744	1.69E-34
THYM	Epifactor	PA2G4	MCRS1	0.867816627	2.97E-38
THYM	Epifactor	PA2G4	NAP1L4	0.868175965	2.55E-38
THYM	Epifactor	PA2G4	TRIM28	0.871054523	7.41E-39
THYM	Epifactor	PA2G4	H2AFX	0.874333774	1.75E-39
THYM	Epifactor	PA2G4	MAZ	0.893086165	1.91E-43
THYM	Epifactor	PA2G4	PPP4C	0.894102302	1.11E-43
THYM	Epifactor	PA2G4	RUVBL2	0.898758128	8.64E-45
THYM	Epifactor	PA2G4	PPM1G	0.913669436	9.59E-49
THYM	IUPHAR	PA2G4	DYRK4	0.806018053	4.19E-29
THYM	IUPHAR	PA2G4	ECE2	0.806520989	3.64E-29
THYM	IUPHAR	PA2G4	CDK4	0.806567297	3.60E-29
THYM	IUPHAR	PA2G4	SIRT6	0.808242108	2.25E-29
THYM	IUPHAR	PA2G4	AURKB	0.819160827	9.47E-31
THYM	IUPHAR	PA2G4	PHKG2	0.821825605	4.23E-31
THYM	IUPHAR	PA2G4	SIRT7	0.823026572	2.93E-31
THYM	IUPHAR	PA2G4	PKMYT1	0.833355485	1.10E-32
THYM	IUPHAR	PA2G4	MFSD2B	0.836380385	4.03E-33
THYM	IUPHAR	PA2G4	PPIA	0.843606158	3.37E-34
THYM	IUPHAR	PA2G4	SUV39H1	0.845554744	1.69E-34
THYM	IUPHAR	PA2G4	TOP1MT	0.857571984	1.90E-36
THYM	IUPHAR	PA2G4	BIRC5	0.862138104	3.10E-37
THYM	IUPHAR	PA2G4	TRIM28	0.871054523	7.41E-39
THYM	Kinase	PA2G4	DYRK4	0.806018053	4.19E-29
THYM	Kinase	PA2G4	CDK4	0.806567297	3.60E-29
THYM	Kinase	PA2G4	AURKB	0.819160827	9.47E-31
THYM	Kinase	PA2G4	PHKG2	0.821825605	4.23E-31
THYM	Kinase	PA2G4	PKMYT1	0.833355485	1.10E-32
THYM	Kinase	PA2G4	TRIM28	0.871054523	7.41E-39
THYM	TF	PA2G4	PIN1	0.822764712	3.17E-31
THYM	TF	PA2G4	CXXC1	0.828849308	4.73E-32
THYM	TF	PA2G4	MYBL2	0.829647309	3.66E-32
THYM	TF	PA2G4	THYN1	0.833869894	9.29E-33
THYM	TF	PA2G4	E2F1	0.839109242	1.60E-33
THYM	TF	PA2G4	MXD3	0.843166711	3.93E-34
THYM	TF	PA2G4	ZNF444	0.845788182	1.55E-34
THYM	TF	PA2G4	ZNF668	0.855613102	4.06E-36
THYM	TF	PA2G4	GTF3A	0.871393876	6.39E-39
THYM	TF	PA2G4	MAZ	0.893086165	1.91E-43
THYM	TSG	PA2G4	FANCG	0.804336421	6.66E-29
THYM	TSG	PA2G4	SIRT6	0.808242108	2.25E-29
THYM	TSG	PA2G4	ANP32A	0.818619676	1.11E-30
THYM	TSG	PA2G4	PIN1	0.822764712	3.17E-31
THYM	TSG	PA2G4	NME1	0.823772194	2.33E-31
THYM	TSG	PA2G4	HTRA2	0.825680593	1.29E-31
THYM	TSG	PA2G4	MYO1A	0.83454189	7.44E-33
THYM	TSG	PA2G4	PFN1	0.834800258	6.83E-33
THYM	TSG	PA2G4	AIP	0.835362209	5.66E-33
THYM	TSG	PA2G4	BRMS1	0.837095786	3.17E-33
THYM	TSG	PA2G4	E2F1	0.839109242	1.60E-33
THYM	TSG	PA2G4	ZNF668	0.855613102	4.06E-36
THYM	TSG	PA2G4	H2AFX	0.874333774	1.75E-39
UCS	Cell metabolism gene	PA2G4	EXOSC5	0.801100574	1.61E-28
UCS	Cell metabolism gene	PA2G4	TIMM17B	0.802343189	1.15E-28
UCS	Cell metabolism gene	PA2G4	TKT	0.806143795	4.05E-29
UCS	Cell metabolism gene	PA2G4	PSME1	0.806218873	3.96E-29
UCS	Cell metabolism gene	PA2G4	SNRPG	0.808425117	2.14E-29
UCS	Cell metabolism gene	PA2G4	POLR2H	0.810084033	1.34E-29
UCS	Cell metabolism gene	PA2G4	GNA15	0.813168281	5.53E-30
UCS	Cell metabolism gene	PA2G4	ZNRD1	0.813880383	4.50E-30
UCS	Cell metabolism gene	PA2G4	TXN	0.818148887	1.28E-30
UCS	Cell metabolism gene	PA2G4	ANP32A	0.818619676	1.11E-30
UCS	Cell metabolism gene	PA2G4	SNRPE	0.819365456	8.90E-31
UCS	Cell metabolism gene	PA2G4	TIMM13	0.819689645	8.08E-31
UCS	Cell metabolism gene	PA2G4	DUT	0.820054159	7.24E-31
UCS	Cell metabolism gene	PA2G4	PHKG2	0.821825605	4.23E-31
UCS	Cell metabolism gene	PA2G4	POLD2	0.822703446	3.23E-31
UCS	Cell metabolism gene	PA2G4	NME1	0.823772194	2.33E-31
UCS	Cell metabolism gene	PA2G4	EXOSC1	0.824514303	1.85E-31
UCS	Cell metabolism gene	PA2G4	ACOT8	0.824935207	1.62E-31
UCS	Cell metabolism gene	PA2G4	LSM3	0.828534356	5.23E-32
UCS	Cell metabolism gene	PA2G4	POLD1	0.828993822	4.52E-32
UCS	Cell metabolism gene	PA2G4	PSMA5	0.829776997	3.51E-32
UCS	Cell metabolism gene	PA2G4	GALK1	0.835762961	4.96E-33
UCS	Cell metabolism gene	PA2G4	PGP	0.836528098	3.84E-33
UCS	Cell metabolism gene	PA2G4	EBP	0.838687751	1.85E-33
UCS	Cell metabolism gene	PA2G4	PSMB7	0.843138988	3.97E-34
UCS	Cell metabolism gene	PA2G4	PSMA6	0.84516514	1.94E-34
UCS	Cell metabolism gene	PA2G4	DGUOK	0.850763333	2.53E-35
UCS	Cell metabolism gene	PA2G4	POLA2	0.852322735	1.42E-35
UCS	Cell metabolism gene	PA2G4	TOMM40	0.852426222	1.36E-35
UCS	Cell metabolism gene	PA2G4	LSM5	0.852761309	1.20E-35
UCS	Cell metabolism gene	PA2G4	TUBA1C	0.858479797	1.33E-36
UCS	Cell metabolism gene	PA2G4	GEMIN6	0.859829703	7.83E-37
UCS	Cell metabolism gene	PA2G4	LSM2	0.860520394	5.95E-37
UCS	Cell metabolism gene	PA2G4	TIMM8B	0.860889474	5.13E-37
UCS	Cell metabolism gene	PA2G4	PAFAH1B3	0.864484328	1.19E-37
UCS	Cell metabolism gene	PA2G4	SNRPD2	0.864610423	1.13E-37
UCS	Cell metabolism gene	PA2G4	TK1	0.868018851	2.72E-38
UCS	Cell metabolism gene	PA2G4	NOP56	0.868610065	2.12E-38
UCS	Cell metabolism gene	PA2G4	PSMB3	0.874850074	1.39E-39
UCS	Cell metabolism gene	PA2G4	POLR3K	0.877372814	4.42E-40
UCS	Cell metabolism gene	PA2G4	PSMC3	0.879268797	1.84E-40
UCS	Cell metabolism gene	PA2G4	PSMD13	0.88343785	2.54E-41
UCS	Cell metabolism gene	PA2G4	SNRPB	0.885959599	7.39E-42
UCS	Cell metabolism gene	PA2G4	PSMA4	0.888364626	2.21E-42
UCS	Cell metabolism gene	PA2G4	SNRPF	0.896567302	2.92E-44
UCS	Cell metabolism gene	PA2G4	LSM4	0.901325394	2.00E-45
UCS	Cell metabolism gene	PA2G4	AAAS	0.904364208	3.36E-46
UCS	Cell metabolism gene	PA2G4	DTYMK	0.906120286	1.17E-46
UCS	Cell metabolism gene	PA2G4	SNRPD1	0.926239878	1.11E-52
UCS	CGC	PA2G4	FANCG	0.804336421	6.66E-29
UCS	CGC	PA2G4	CDK4	0.806567297	3.60E-29
UCS	CGC	PA2G4	TFPT	0.812651051	6.42E-30
UCS	CGC	PA2G4	POLD1	0.828993822	4.52E-32
UCS	CGC	PA2G4	FEN1	0.834098405	8.61E-33
UCS	CGC	PA2G4	RECQL4	0.837531967	2.74E-33
UCS	CGC	PA2G4	SDHAF2	0.845491748	1.72E-34
UCS	Epifactor	PA2G4	EXOSC5	0.801100574	1.61E-28
UCS	Epifactor	PA2G4	SS18L2	0.801333636	1.51E-28
UCS	Epifactor	PA2G4	NOC2L	0.8028747	9.94E-29
UCS	Epifactor	PA2G4	HIST1H3F	0.80379747	7.73E-29
UCS	Epifactor	PA2G4	SIRT6	0.808242108	2.25E-29
UCS	Epifactor	PA2G4	INO80C	0.811317999	9.42E-30
UCS	Epifactor	PA2G4	TFPT	0.812651051	6.42E-30
UCS	Epifactor	PA2G4	HIST1H2AJ	0.817509842	1.55E-30
UCS	Epifactor	PA2G4	ANP32A	0.818619676	1.11E-30
UCS	Epifactor	PA2G4	AURKB	0.819160827	9.47E-31
UCS	Epifactor	PA2G4	SIRT7	0.823026572	2.93E-31
UCS	Epifactor	PA2G4	EXOSC1	0.824514303	1.85E-31
UCS	Epifactor	PA2G4	CXXC1	0.828849308	4.73E-32
UCS	Epifactor	PA2G4	BRMS1	0.837095786	3.17E-33
UCS	Epifactor	PA2G4	TAF10	0.837963087	2.36E-33
UCS	Epifactor	PA2G4	SUV39H1	0.845554744	1.69E-34
UCS	Epifactor	PA2G4	MCRS1	0.867816627	2.97E-38
UCS	Epifactor	PA2G4	NAP1L4	0.868175965	2.55E-38
UCS	Epifactor	PA2G4	TRIM28	0.871054523	7.41E-39
UCS	Epifactor	PA2G4	H2AFX	0.874333774	1.75E-39
UCS	Epifactor	PA2G4	MAZ	0.893086165	1.91E-43
UCS	Epifactor	PA2G4	PPP4C	0.894102302	1.11E-43
UCS	Epifactor	PA2G4	RUVBL2	0.898758128	8.64E-45
UCS	Epifactor	PA2G4	PPM1G	0.913669436	9.59E-49
UCS	IUPHAR	PA2G4	DYRK4	0.806018053	4.19E-29
UCS	IUPHAR	PA2G4	ECE2	0.806520989	3.64E-29
UCS	IUPHAR	PA2G4	CDK4	0.806567297	3.60E-29
UCS	IUPHAR	PA2G4	SIRT6	0.808242108	2.25E-29
UCS	IUPHAR	PA2G4	AURKB	0.819160827	9.47E-31
UCS	IUPHAR	PA2G4	PHKG2	0.821825605	4.23E-31
UCS	IUPHAR	PA2G4	SIRT7	0.823026572	2.93E-31
UCS	IUPHAR	PA2G4	PKMYT1	0.833355485	1.10E-32
UCS	IUPHAR	PA2G4	MFSD2B	0.836380385	4.03E-33
UCS	IUPHAR	PA2G4	PPIA	0.843606158	3.37E-34
UCS	IUPHAR	PA2G4	SUV39H1	0.845554744	1.69E-34
UCS	IUPHAR	PA2G4	TOP1MT	0.857571984	1.90E-36
UCS	IUPHAR	PA2G4	BIRC5	0.862138104	3.10E-37
UCS	IUPHAR	PA2G4	TRIM28	0.871054523	7.41E-39
UCS	Kinase	PA2G4	DYRK4	0.806018053	4.19E-29
UCS	Kinase	PA2G4	CDK4	0.806567297	3.60E-29
UCS	Kinase	PA2G4	AURKB	0.819160827	9.47E-31
UCS	Kinase	PA2G4	PHKG2	0.821825605	4.23E-31
UCS	Kinase	PA2G4	PKMYT1	0.833355485	1.10E-32
UCS	Kinase	PA2G4	TRIM28	0.871054523	7.41E-39
UCS	TF	PA2G4	PIN1	0.822764712	3.17E-31
UCS	TF	PA2G4	CXXC1	0.828849308	4.73E-32
UCS	TF	PA2G4	MYBL2	0.829647309	3.66E-32
UCS	TF	PA2G4	THYN1	0.833869894	9.29E-33
UCS	TF	PA2G4	E2F1	0.839109242	1.60E-33
UCS	TF	PA2G4	MXD3	0.843166711	3.93E-34
UCS	TF	PA2G4	ZNF444	0.845788182	1.55E-34
UCS	TF	PA2G4	ZNF668	0.855613102	4.06E-36
UCS	TF	PA2G4	GTF3A	0.871393876	6.39E-39
UCS	TF	PA2G4	MAZ	0.893086165	1.91E-43
UCS	TSG	PA2G4	FANCG	0.804336421	6.66E-29
UCS	TSG	PA2G4	SIRT6	0.808242108	2.25E-29
UCS	TSG	PA2G4	ANP32A	0.818619676	1.11E-30
UCS	TSG	PA2G4	PIN1	0.822764712	3.17E-31
UCS	TSG	PA2G4	NME1	0.823772194	2.33E-31
UCS	TSG	PA2G4	HTRA2	0.825680593	1.29E-31
UCS	TSG	PA2G4	MYO1A	0.83454189	7.44E-33
UCS	TSG	PA2G4	PFN1	0.834800258	6.83E-33
UCS	TSG	PA2G4	AIP	0.835362209	5.66E-33
UCS	TSG	PA2G4	BRMS1	0.837095786	3.17E-33
UCS	TSG	PA2G4	E2F1	0.839109242	1.60E-33
UCS	TSG	PA2G4	ZNF668	0.855613102	4.06E-36
UCS	TSG	PA2G4	H2AFX	0.874333774	1.75E-39

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	PA2G4	NMD3	-1.37228657083066	0.000137265065605683
KIRP	PA2G4	RPL18A	-1.51651392808885	0.00016188295558095
BLCA	PA2G4	RPL5	-3.50581551367555	0.00026702880859375
STAD	PA2G4	RPL5	2.24361928856279	0.000433447770774365
COAD	PA2G4	RPL13	2.11745314482912	0.000465095043182374
KIRC	PA2G4	NMD3	1.42972481111117	0.000552342824201752
THCA	PA2G4	RPLP0	-1.74888680592094	0.000772056397653126
THCA	PA2G4	RPL4	1.38794063541307	0.00128543522995411
PRAD	PA2G4	RPL4	1.2589775892273	0.00136912931788367
PRAD	PA2G4	RPL18A	1.40600175748499	0.00205137828390396
KICH	PA2G4	RPLP0	-1.2840132894761	0.00341922044754028
CHOL	PA2G4	NMD3	-4.91333963004969	0.00390625
ESCA	PA2G4	RPL15	1.76629417535644	0.0048828125
STAD	PA2G4	RPL4	1.50541710129002	0.00647870777174831
COAD	PA2G4	RPLP0	1.273203752387	0.011966735124588
BLCA	PA2G4	RPL4	-1.27208291287992	0.0180816650390625
BRCA	PA2G4	RPL23A	-1.00708839787202	0.0188078315893149
KICH	PA2G4	RPL5	1.79380241489629	0.0219083428382874
STAD	PA2G4	RPL13	-1.17078722854876	0.0294188209809363
KICH	PA2G4	RPL13	-5.95618047175394	0.0366820693016052
KIRP	PA2G4	RPL23A	-1.52936455976751	1.2875534594059e-06
KIRC	PA2G4	RPLP0	-3.51594265725619	1.68239022549371e-11
KIRC	PA2G4	RPL13	-3.44015571111292	2.58914497097505e-10
LUAD	PA2G4	LSG1	-2.26390863957415	2.83612198579349e-08
KIRC	PA2G4	RPL4	-2.62009040507781	3.30026076039221e-08
LUAD	PA2G4	RPLP0	-1.80912884665876	3.32622703073417e-05
KIRP	PA2G4	RPLP0	-2.44352164022892	5.8719888329506e-07
STAD	PA2G4	LSG1	-1.59961050160694	5.8719888329506e-07
LUAD	PA2G4	RPL23A	-2.22526108535187	7.13242533835451e-05
KIRC	PA2G4	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PA2G4

SGK1, ATR, HDAC2, RB1, ERBB3, MTOR, AR, USP39, ATG101, DDA1, GBAS, NRBF2, PDPK1, PIK3C2A, PRKAA1, PRKAG1, SH3GLB2, UBA5, RNF20, IKBKG, SIN3A, MDM2, AKT1, HDAC5, AI837181, TERF1, CDK2, FUS, UBE2I, NPM1, ATP6V0A1, SERBP1, ATP5B, EIF2A, LIG4, NCL, TOP1, IGF2BP2, RPLP0, HIST1H1A, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPL30, RPLP2, EEF2K, FN1, UBL4A, ITGA4, HMGA1, HMGA2, EXOSC5, NELFB, DIMT1, EIF3K, MAP2, NMT1, FAU, G3BP1, IGF2BP3, KRT17, RPS27L, RPL23A, YBX1, HSPA4, STUB1, DHX9, LAMB1, DDX21, HSPA1B, PKN1, VIM, ACTB, HNRNPA2B1, MOV10, CUL7, OBSL1, CCDC8, CDKN2A, HNRNPK, ESR1, TMED7, NTRK1, MYCBP, OFD1, SPICE1, RPL10, Eif3a, Tmed2, Rpl35, Rrbp1, FOXB1, FOXH1, FOXI2, FOXL1, MCM2, Ksr1, U2AF2, EIF2S2, FBXW7, PTP4A1, PTPN6, ANXA5, GPI, TRAP1, UBE2N, SND1, SNRPB2, NANS, PLS3, EIF5B, IDH2, PDIA3, MRPL12, CRNN, ZNF207, CPNE3, CS, PYGL, SF3A3, DNAJC8, CPSF6, PPA1, HPRT1, SF3A1, ECHS1, SRP68, MYL12B, AIMP1, CBS, BRCA1, YAP1, KCTD12, PPTC7, PHOSPHO1, CTNNB1, HDAC4, PRPF8, EFTUD2, AAR2, PIH1D1, RPTOR, ESR2, MYC, ATG16L1, ACTC1, PHB, MAPT, USP14, NR2C2, AGRN, DDX60, IRF2, MAP3K14, MAB21L2, VAMP5, RRN3, ITFG1, BIRC3, LMBR1L, NFX1, WWP2, TRIM28, PARK2, LRRK2, CMTR1, PINK1, HCVgp1, ZC3H18, HSPA5, MYBPC2, PDIA6, CETN3, TARBP1, M, nsp4, CIT, CHMP4C, KIF14, PRC1, ARHGAP36, DOCK8, ARHGAP39, ARHGEF39, Pik3r2, NDN, ZNF263, NUPR1, BRD4, Apc2, RBM39, YWHAE, ASXL1, EIF3H, DNAJC2, TRIM24, OGT, CD274, DDRGK1, LRRC59, TRIM37, FZR1, NAA40, TMED2, EP300, SUV39H1, RBFOX2, Eif5, ORF7a, RCHY1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PA2G4	BLCA	chr12	56505295	56505295	G	C	Missense_Mutation	p.Q367H	4
PA2G4	CHOL	chr12	56503676	56503676	G	T	Missense_Mutation	p.D196Y	4
PA2G4	HNSC	chr12	56506656	56506656	A	G	Missense_Mutation	p.N390S	3
PA2G4	PAAD	chr12	56505030	56505030	C	A	Silent	p.T334T	3
PA2G4	SKCM	chr12	56504236	56504236	T	C	Missense_Mutation	p.V228A	3
PA2G4	SKCM	chr12	56504387	56504387	C	T	Silent	p.P251P	3
PA2G4	BLCA	chr12	56505295	56505295	G	C	Missense_Mutation		2
PA2G4	CESC	chr12	56503680	56503680	G	C	Missense_Mutation		2
PA2G4	HNSC	chr12	56498590	56498590	G	A	Missense_Mutation	p.M23I	2
PA2G4	SARC	chr12	56501326	56501327	AA	-	Frame_Shift_Del	p.K139fs	2
PA2G4	CESC	chr12	56504386	56504386	C	T	Missense_Mutation		2
PA2G4	STAD	chr12	56505302	56505303	-	A	Frame_Shift_Ins	p.K369fs	2
PA2G4	LIHC	chr12	56504412	56504412	A	-	Frame_Shift_Del	p.K260fs	2
PA2G4	PAAD	chr12	56505030	56505030	C	A	Silent		2
PA2G4	HNSC	chr12	56504208	56504208	G	A	Missense_Mutation	p.E219K	2
PA2G4	LGG	chr12	56504240	56504240	C	T	Silent		2
PA2G4	HNSC	chr12	56504217	56504217	G	T	Nonsense_Mutation	p.E222*	2
PA2G4	TGCT	chr12	56505268	56505268	C	T	Silent		2
PA2G4	BLCA	chr12	56504454	56504454	G	A	Missense_Mutation		2
PA2G4	KIRC	chr12	56505302	56505302	A	-	Frame_Shift_Del	p.K369fs	2
PA2G4	LGG	chr12	56504345	56504345	C	T	Silent		2
PA2G4	TGCT	chr12	56505268	56505268	C	T	Silent	p.L358L	2
PA2G4	UCEC	chr12	56504379	56504379	C	T	Nonsense_Mutation	p.R249*	2
PA2G4	KIRC	chr12	56504194	56504194	A	-	Frame_Shift_Del	p.E214fs	2
PA2G4	LGG	chr12	56504773	56504773	C	T	Missense_Mutation		2
PA2G4	UCEC	chr12	56505310	56505310	G	T	Missense_Mutation	p.K372N	2
PA2G4	LAML	chr12	54787269	54787269	G	A	Missense_Mutation	p.A119T	2
PA2G4	LGG	chr12	56504773	56504773	C	T	Missense_Mutation	p.R290W	2
PA2G4	THCA	chr12	56500441	56500441	A	G	Missense_Mutation	p.D53G	2
PA2G4	ACC	chr12	56504205	56504205	T	A	Missense_Mutation	p.F218I	2
PA2G4	BLCA	chr12	56500804	56500804	A	G	Missense_Mutation	p.N83S	2
PA2G4	LGG	chr12	56501319	56501319	A	G	Silent	p.T136T	2
PA2G4	COAD	chr12	56500503	56500504	AA	-	Splice_Site	.	2
PA2G4	THYM	chr12	56498589	56498589	T	A	Missense_Mutation		2
PA2G4	LGG	chr12	56504345	56504345	C	T	Silent	p.A237A	2
PA2G4	STAD	chr12	56505000	56505000	G	A	Silent	p.L324L	2
PA2G4	LIHC	chr12	56498590	56498590	G	-	Frame_Shift_Del	p.M23fs	2
PA2G4	HNSC	chr12	56504766	56504766	G	C	Missense_Mutation	p.K287N	2
PA2G4	LGG	chr12	56504240	56504240	C	T	Silent	p.L229L	2
PA2G4	STAD	chr12	56504448	56504448	C	T	Missense_Mutation	p.R272C	2
PA2G4	COAD	chr12	56500503	56500506	AAAA	-	Splice_Site	.	1
PA2G4	LIHC	chr12	56503708	56503708	A	G	Silent	p.T206T	1
PA2G4	LUAD	chr12	56500978	56500979	GG	TT	Missense_Mutation	p.G111L	1
PA2G4	THYM	chr12	56504421	56504421	C	T	Missense_Mutation		1
PA2G4	SARC	chr12	56505045	56505045	G	T	Missense_Mutation		1
PA2G4	LGG	chr12	56505011	56505011	A	G	Missense_Mutation	p.N328S	1
PA2G4	STAD	chr12	56505008	56505008	C	A	Missense_Mutation	p.P327H	1
PA2G4	ESCA	chr12	56505296	56505296	A	-	Frame_Shift_Del	p.K369fs	1
PA2G4	LIHC	chr12	56505089	56505090	-	A	Frame_Shift_Ins	p.Q354fs	1
PA2G4	LUSC	chr12	56500497	56500497	A	T	Nonsense_Mutation	p.K72*	1
PA2G4	THYM	chr12	56500414	56500414	C	T	Missense_Mutation	p.S44L	1
PA2G4	BLCA	chr12	56505038	56505038	C	G	Missense_Mutation		1
PA2G4	LGG	chr12	56504771	56504771	C	A	Missense_Mutation	p.A289D	1
PA2G4	ESCA	chr12	56505296	56505296	A	-	Frame_Shift_Del		1
PA2G4	THYM	chr12	56504421	56504421	C	T	Missense_Mutation	p.R263C	1
PA2G4	BLCA	chr12	56500804	56500804	A	G	Missense_Mutation		1
PA2G4	SARC	chr12	56501329	56501330	-	C	Frame_Shift_Ins	p.D141fs	1
PA2G4	CESC	chr12	56504248	56504248	C	G	Missense_Mutation		1
PA2G4	TGCT	chr12	56500421	56500421	G	T	Silent		1
PA2G4	ESCA	chr12	56505296	56505296	A	-	Frame_Shift_Del	p.Q367fs	1
PA2G4	LIHC	chr12	56500989	56500989	G	-	Frame_Shift_Del	p.V114fs	1
PA2G4	THYM	chr12	56498550	56498550	A	G	Missense_Mutation	p.Q10R	1
PA2G4	BLCA	chr12	56500496	56500496	G	A	Silent		1
PA2G4	SARC	chr12	56501332	56501332	G	A	Missense_Mutation	p.D141N	1
PA2G4	CESC	chr12	56504248	56504248	C	G	Nonsense_Mutation	p.S232*	1
PA2G4	LGG	chr12	56501319	56501319	A	G	Silent		1
PA2G4	ESCA	chr12	56505296	56505296	A	-	Frame_Shift_Del	p.K373fs	1
PA2G4	LIHC	chr12	56500785	56500785	C	-	Frame_Shift_Del	p.P77fs	1
PA2G4	PRAD	chr12	56503666	56503666	G	A	Silent	p.Q192Q	1
PA2G4	THYM	chr12	56504360	56504360	G	T	Missense_Mutation	p.Q242H	1
PA2G4	CESC	chr12	56504386	56504386	C	T	Missense_Mutation	p.P251L	1
PA2G4	GBM	chr12	56501039	56501039	A	G	Missense_Mutation	p.Q131_splice	1
PA2G4	LIHC	chr12	56505037	56505037	C	-	Frame_Shift_Del	p.P337fs	1
PA2G4	READ	chr12	56504362	56504362	G	T	Missense_Mutation	p.R243I	1
PA2G4	BLCA	chr12	56501350	56501350	C	T	Missense_Mutation	p.H147Y	1
PA2G4	CESC	chr12	56503680	56503680	G	C	Missense_Mutation	p.G197A	1
PA2G4	TGCT	chr12	56501389	56501389	G	A	Missense_Mutation	p.G160R	1
PA2G4	SARC	chr12	56501326	56501327	AA	-	Frame_Shift_Del		1
PA2G4	GBM	chr12	56505022	56505022	C	T	Missense_Mutation	p.R332W	1
PA2G4	SKCM	chr12	56505284	56505284	C	T	Nonsense_Mutation	p.R364*	1
PA2G4	LGG	chr12	56505011	56505011	A	G	Missense_Mutation		1
PA2G4	LIHC	chr12	56505302	56505302	A	-	Frame_Shift_Del	p.K373fs	1
PA2G4	THCA	chr12	56500441	56500441	A	G	Missense_Mutation		1
PA2G4	SARC	chr12	56501329	56501330	-	-	Frame_Shift_Ins		1
PA2G4	HNSC	chr12	56504208	56504208	G	A	Missense_Mutation		1
PA2G4	BLCA	chr12	56505038	56505038	C	G	Missense_Mutation	p.P337R	1
PA2G4	SKCM	chr12	56504991	56504991	T	C	Silent	p.F321F	1
PA2G4	COAD	chr12	56500503	56500503	A	-	Splice_Site	.	1
PA2G4	LIHC	chr12	56500791	56500791	A	G	Missense_Mutation		1
PA2G4	LUAD	chr12	56500854	56500854	C	T	Missense_Mutation	p.L100F	1
PA2G4	SARC	chr12	56501332	56501332	G	A	Missense_Mutation		1
PA2G4	HNSC	chr12	56498590	56498590	G	A	Missense_Mutation		1
PA2G4	SKCM	chr12	56503697	56503697	C	G	Missense_Mutation	p.Q203E	1
PA2G4	LIHC	chr12	56503665	56503665	A	G	Missense_Mutation		1
PA2G4	LUAD	chr12	56500856	56500856	C	T	Silent	p.L100L	1
PA2G4	SARC	chr12	56498365	56498365	C	G	Missense_Mutation		1
PA2G4	ACC	chr12	56504465	56504465	G	A	Silent	p.P277P	1
PA2G4	HNSC	chr12	56506656	56506656	A	G	Missense_Mutation		1
PA2G4	BLCA	chr12	56504454	56504454	G	A	Missense_Mutation	p.D274N	1
PA2G4	COAD	chr12	56500503	56500505	AAA	-	Splice_Site	.	1
PA2G4	LUAD	chr12	56498499	56498499	G	A	Translation_Start_Site		1
PA2G4	THYM	chr12	56498550	56498550	A	G	Missense_Mutation		1
PA2G4	SARC	chr12	56505265	56505265	C	A	Silent		1
PA2G4	BLCA	chr12	56501350	56501350	C	T	Missense_Mutation		1
PA2G4	CESC	chr12	56500983	56500983	C	A	Silent		1

Copy number variation (CNV) of PA2G4
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PA2G4
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
96169	BLCA	TCGA-DK-A6B6-01A	ESYT1	chr12	56522493	+	PA2G4	chr12	56500372	+
96169	N/A	EC544564	LINC00886	chr3	156527157	-	PA2G4	chr12	56506739	+
87232	LUAD	TCGA-86-7955-01A	PA2G4	chr12	56498609	+	ANKRD52	chr12	56651695	-
103309	N/A	CV396726	PA2G4	chr12	56507469	-	JAK1	chr1	65362875	-
62174	N/A	CA488250	PA2G4	chr12	56504252	+	KIF26A	chr14	104640623	+
62174	N/A	AI199410	PA2G4	chr12	56506605	-	LINC00886	chr3	156527088	+
72858	SARC	TCGA-DX-A3LY-01B	PA2G4	chr12	56498609	+	MARK1	chr1	220752696	+
96169	N/A	EC571880	PA2G4	chr12	56506839	-	PA2G4	chr12	56506860	+
62174	UCEC	TCGA-AJ-A3BF	PA2G4	chr12	56503719	+	RAB5B	chr12	56385880	+
62174	UCEC	TCGA-AJ-A3BF-01A	PA2G4	chr12	56503719	+	RAB5B	chr12	56385881	+
74660	N/A	BM014946	PA2G4	chr12	56506934	+	TIMMDC1	chr3	119239138	+
96169	N/A	AA603936	SEMA4D	chr9	92066501	-	PA2G4	chr12	56507691	-
96173	GBM	TCGA-32-1982	UBE2L3	chr22	21922060	+	PA2G4	chr12	56503013	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	PA2G4	0.00222440276715497	0.062

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	PA2G4	0.00913691895550799	0.29
THCA	PA2G4	0.0332733426857533	1
LAML	PA2G4	0.00882050089362794	0.29
THYM	PA2G4	0.0227028163848829	0.7

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0024623	Malignant neoplasm of stomach	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human