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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS7 (NCBI Gene ID:51081)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS7
	Gene ID: 51081
	Gene Symbol	MRPS7
	Gene ID	51081
	Gene Name	mitochondrial ribosomal protein S7
	Synonyms	COXPD34\|MRP-S\|MRP-S7\|RP-S7\|RPMS7\|S7mt\|bMRP27a
	Cytomap	17q25.1
	Type of Gene	protein-coding
	Description	28S ribosomal protein S7, mitochondrial30S ribosomal protein S7 homologbMRP-27amitochondrial small ribosomal subunit protein uS7m
	Modification date	20200313
	UniProtAcc	Q9Y2R9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPS7[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS7	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	MRPS7	1.27029395477208	0.00182077236082954
BRCA	MRPS7	-2.12787460270434	9.33194208595055e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUSC	MRPS7	0.106030745	0.035811112
TGCT	MRPS7	0.107848737	0.049552381

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS7 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	TSG	MRPS7	PHB	0.910086104	4.69E-18
DLBC	Cell metabolism gene	MRPS7	SNRPB	0.803523035	6.24E-12
DLBC	Cell metabolism gene	MRPS7	FPGS	0.804733601	5.49E-12
DLBC	Cell metabolism gene	MRPS7	PSMA7	0.804852156	5.42E-12
DLBC	Cell metabolism gene	MRPS7	POLR2H	0.806174058	4.71E-12
DLBC	Cell metabolism gene	MRPS7	IDH3B	0.80727571	4.18E-12
DLBC	Cell metabolism gene	MRPS7	DTYMK	0.810259185	3.02E-12
DLBC	Cell metabolism gene	MRPS7	POLR2F	0.814547116	1.88E-12
DLBC	Cell metabolism gene	MRPS7	PSMC3	0.817275706	1.38E-12
DLBC	Cell metabolism gene	MRPS7	ITPA	0.822274047	7.71E-13
DLBC	Cell metabolism gene	MRPS7	PMPCA	0.823914537	6.35E-13
DLBC	Cell metabolism gene	MRPS7	PSMB6	0.824141705	6.18E-13
DLBC	Cell metabolism gene	MRPS7	PSMA4	0.826844044	4.47E-13
DLBC	Cell metabolism gene	MRPS7	TIMM10	0.82704594	4.36E-13
DLBC	Cell metabolism gene	MRPS7	POLR2I	0.831624212	2.48E-13
DLBC	Cell metabolism gene	MRPS7	NME2	0.833215238	2.03E-13
DLBC	Cell metabolism gene	MRPS7	POLR2L	0.833476817	1.96E-13
DLBC	Cell metabolism gene	MRPS7	SNRPD3	0.836281398	1.37E-13
DLBC	Cell metabolism gene	MRPS7	PSMB3	0.838238849	1.06E-13
DLBC	Cell metabolism gene	MRPS7	ATP5G1	0.842009449	6.45E-14
DLBC	Cell metabolism gene	MRPS7	SNRPD2	0.846117005	3.69E-14
DLBC	Cell metabolism gene	MRPS7	TIMM50	0.871682125	7.53E-16
DLBC	Cell metabolism gene	MRPS7	TIMM13	0.876121017	3.52E-16
DLBC	Epifactor	MRPS7	MBD3	0.806103245	4.75E-12
DLBC	Epifactor	MRPS7	PRPF31	0.827538091	4.10E-13
DLBC	Epifactor	MRPS7	RUVBL2	0.8282922	3.74E-13
DLBC	Epifactor	MRPS7	FBL	0.830868379	2.72E-13
DLBC	IUPHAR	MRPS7	PSMB6	0.824141705	6.18E-13
DLBC	TF	MRPS7	MBD3	0.806103245	4.75E-12
DLBC	TF	MRPS7	NME2	0.833215238	2.03E-13
DLBC	TSG	MRPS7	GADD45GIP1	0.817632571	1.32E-12
DLBC	TSG	MRPS7	PARK7	0.825386814	5.33E-13
DLBC	TSG	MRPS7	PHB	0.893982299	1.20E-17
GBM	Cell metabolism gene	MRPS7	MED31	0.802489336	5.68E-40
GBM	Cell metabolism gene	MRPS7	TIMM10	0.809539979	3.57E-41
GBM	Cell metabolism gene	MRPS7	PSMB3	0.828578631	1.10E-44
GBM	Cell metabolism gene	MRPS7	ATP5G1	0.829824588	6.27E-45
GBM	Cell metabolism gene	MRPS7	NME1	0.831793236	2.55E-45
GBM	Cell metabolism gene	MRPS7	SNRPG	0.832234984	2.08E-45
GBM	Cell metabolism gene	MRPS7	TIMM8B	0.84187265	2.10E-47
GBM	Cell metabolism gene	MRPS7	SUCLG1	0.859871609	1.63E-51
GBM	Epifactor	MRPS7	DPY30	0.810115523	2.84E-41
GBM	IUPHAR	MRPS7	ITGAE	0.800063858	1.43E-39
GBM	TSG	MRPS7	NME1	0.831793236	2.55E-45
KICH	Cell metabolism gene	MRPS7	SAT2	0.825511579	7.89E-24
KICH	Cell metabolism gene	MRPS7	MLX	0.839662137	2.54E-25
KICH	TF	MRPS7	MLX	0.839662137	2.54E-25
PCPG	TSG	MRPS7	PHB	0.80257939	2.27E-43
TGCT	Cell metabolism gene	MRPS7	TIMM22	0.800481075	4.64E-36
TGCT	Cell metabolism gene	MRPS7	NUP85	0.808218264	3.04E-37
TGCT	Cell metabolism gene	MRPS7	PSMB6	0.829665058	7.95E-41
TGCT	IUPHAR	MRPS7	SLC35B1	0.82259081	1.37E-39
TGCT	IUPHAR	MRPS7	PSMB6	0.829665058	7.95E-41
TGCT	TSG	MRPS7	PHB	0.853728706	1.71E-45
THYM	TSG	MRPS7	PHB	0.82351243	2.52E-31
UCS	TSG	MRPS7	PHB	0.82351243	2.52E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	MRPS7	MRPS12	2.11566333114824	0.000125885009765625
BRCA	MRPS7	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MRPS7	MRPS5	1.25108287838437	0.000249803066253662
STAD	MRPS7	MRPS16	-1.64208084987431	0.00239070039242506
KIRC	MRPS7	MRPS15	1.11572283836012	0.00361818577801855
ESCA	MRPS7	MRPS12	-1.86248549814506	0.0048828125
PRAD	MRPS7	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MRPS7	MRPS16	-2.01564621821803	0.00518989327406416
CHOL	MRPS7	MRPS6	2.57097392409939	0.0078125
KICH	MRPS7	MRPS2	1.26543989555015	0.0114533305168152
LUSC	MRPS7	MRPS6	-1.26158810839259	0.013873001943322
THCA	MRPS7	MRPS15	-1.19960602422995	0.0140154883942907
ESCA	MRPS7	MRPS5	-2.15440118747854	0.0185546875
ESCA	MRPS7	MRPS2	-3.20556788084675	0.0244140625
HNSC	MRPS7	MRPS12	1.33677139927136	0.0248336488591576
THCA	MRPS7	MRPS11	-3.10694728540962	0.0252226935182201
BLCA	MRPS7	MRPS11	-2.30276998968219	0.040130615234375
LUAD	MRPS7	MRPS12	-5.3399185683719	1.00823612619819e-08
THCA	MRPS7	MRPS10	1.33413691764991	1.55171507174296e-05
BRCA	MRPS7	MRPS12	-1.59537235222597	1.66215672512325e-20
LUAD	MRPS7	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MRPS7	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	MRPS7	MRPS2	-2.70930846488508	1.92864354932136e-09
LUAD	MRPS7	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MRPS7	MRPS11	-1.24304977976804	2.31302509538916e-07
LIHC	MRPS7	MRPS12	2.67189430810317	2.56696988045444e-05
KICH	MRPS7	MRPS12	1.48941080926405	3.19480895996094e-05
PRAD	MRPS7	MRPS6	1.00673230965164	3.48152859299693e-07
LUAD	MRPS7	MRPS14	-3.02634914022647	4.24616078981701e-06
LIHC	MRPS7	MRPS2	-1.14771055358828	4.2584580238307e-05
LUSC	MRPS7	MRPS5	-7.65956389962319	4.27210217182982e-06
KIRC	MRPS7	MRPS6	-3.12621933743663	4.95376546353503e-10
LUSC	MRPS7	MRPS11	-2.9004097541444	5.43966600483641e-07
LUSC	MRPS7	MRPS14	-3.86726163364221	6.1453992201761e-05
KICH	MRPS7	MRPS6	-1.34376231922276	7.49826431274414e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS7

ASF1B, UBC, ICT1, Ybx1, Cdca8, CUL3, CAND1, MRPS25, MRPL1, MRPS9, MRPL54, MRPL28, TUFM, EEF1A1, HNRNPAB, ACTA2, PSMA5, RNMTL1, C1QBP, PARK2, SMURF2, GRSF1, CEP57, CEP76, TUBG1, TUBGCP3, TUBGCP4, RNF2, TRA2A, RPL6, MRPS2, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS5, IFI30, NTRK1, GFM1, AK2, MRPL16, MRPL18, MRPL2, MRPS35, NDUFB10, POLR3A, RPL11, RPL17, RPL23A, RPS15A, RPL8, MAGEA1, Ppp2ca, Set, CDC14B, DUSP11, USP28, FEZ2, GUF1, MRPS27, MRPS34, MRPS15, MRPS11, TOM1L1, E4F1, ZNF331, RBM42, ZNF133, AURKAIP1, CALU, TP53BP1, GPC6, SNRNP70, ZBTB48, ZNF408, ZFC3H1, CDK5RAP3, RPL7, ANKRD28, CTBP2, ZNF2, NCL, ZUFSP, PYHIN1, EFTUD2, RIOK1, FGF11, HEXIM1, MEPCE, LARP7, RECQL4, HABP4, SERBP1, MB21D1, MYC, FBL, HIST1H3A, RPS6, MRM1, HSPD1, PDK1, TRMT61B, PHB, NR2C2, NHLRC2, TCF7L2, ALYREF, Dppa3, DUSP14, PTPN3, ITFG1, HMGB1, NFX1, PLEKHA4, RAD18, PTEN, AXL, FGFR1, GRB7, PTPRR, SRC, PARL, ESR1, IMMP2L, CELF1, DAZL, ELAVL1, IGF2BP1, IGF2BP2, MEX3B, NXF1, XRN2, ZC3HAV1, RBMS1, ARHGAP20, ARHGAP36, Arhgap33, ARHGAP39, ARHGEF26, PLEKHG4B, ACAD9, AUH, C12orf65, C17orf80, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, CLPB, COX15, CRYZ, CS, DDX28, DHX30, FASTKD2, FASTKD3, FASTKD5, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, VWA8, EXD2, CLPP, MAFB, Apc2, NR3C1, DNAJC21, DNAJA3, DNAJC15, DNAJC19, DNAJC28, DNAJC30, DNAJC4, HSCB, HSPA9, REPIN1, MRPS10, RPL7L1, REXO4, HADHB, RPL35, MRPS14, SET, RRP1B, KRR1, NOP16, ZBTB24, DDX58, nsp2, TULP3, UFL1, DDRGK1, AARS2, COX8A, PDHA1, USP15, FZR1, WDR5, MAP4K3, ZBTB2, H2AFB3, GNL2, SRP14, RRS1, PRR3, ABT1, DNA2, RPL3, ZNF17, RPL26, SRSF1, ZNF263, MRPS18B, MRPS23, ZKSCAN8, FAU, YBX1, SULF2, PPAN, LIN28B, MRPS6, SRSF5, SRSF6, RPS9, ZNF467, GLI4, FAM120A, ZNF460, H2AFX, MRPS18C, SRSF4, ZBTB47, RBMS2, H1FNT, CCDC140, SRSF3, MRPS17, RPL19, YBX2, RPL26L1, RPL13, RBM47, CCDC59, RPL37, SURF6, UTP23, ZNF485, CTBP1, THAP3, CBX6, FGF17, APOBEC3D, CYP24A1, DAP3, HIST1H2AM, MRPS33, ADCK4, MRPS24, ZNF574, RPL4, RPL10, MCAT, RPL36AL, LARS2, LIN28A, HECTD3, NEIL1, ZC3H3, IDH3G, PTCD1, HARS2, ZZEF1, ACSF3, ERAL1, SRSF7, RPSAP58, WIPI1, FBXW7, TOP3B, RCHY1, CCNF, KLF12, TLX2, KLF15, KLF16, KLF4, KLF8, SOX15, TLX1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPS7	chr17	73258479	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73258498	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73258504	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73258564	T	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73258564	T	TC	Duplication	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73258570	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73258570	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73258570	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73258611	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS7	chr17	73259083	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73259101	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73259153	T	TA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73259606	G	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73259836	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73261637	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73261773	T	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73261779	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS7	chr17	73261782	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_34	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
MRPS7	chr17	73261825	A	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_34	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS7	chr17	73261851	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS7	chr17	73261868	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS7	chr17	73261899	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS7	chr17	73261920	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS7	chr17	73261929	C	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPS7	chr17	73261963	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS7	chr17	73262270	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPS7	chr17	73262293	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS7	BRCA	chr17	73257986	73257986	C	T	Missense_Mutation	p.A2V	5
MRPS7	BRCA	chr17	73261843	73261843	G	C	Missense_Mutation	p.E190Q	4
MRPS7	UCS	chr17	73258657	73258657	G	C	Missense_Mutation	p.V55L	3
MRPS7	ACC	chr17	73258729	73258729	G	T	Missense_Mutation	p.A79S	3
MRPS7	BRCA	chr17	73261941	73261941	G	A	Silent	p.R222	3
MRPS7	THYM	chr17	73258007	73258007	C	G	Missense_Mutation	p.A9G	3
MRPS7	UCEC	chr17	73261847	73261847	G	A	Missense_Mutation	p.C191Y	3
MRPS7	SARC	chr17	73258543	73258543	G	T	Splice_Site		3
MRPS7	STAD	chr17	73259534	73259534	C	A	Missense_Mutation	p.N151K	2
MRPS7	BRCA	chr17	73259535	73259536	TG	-	Frame_Shift_Del	p.C152fs	2
MRPS7	UCS	chr17	73259478	73259478	G	A	Missense_Mutation	p.E133K	2
MRPS7	CESC	chr17	73257986	73257986	C	T	Missense_Mutation		2
MRPS7	UCEC	chr17	73258680	73258680	G	T	Missense_Mutation	p.E62D	2
MRPS7	BLCA	chr17	73258010	73258010	G	A	Missense_Mutation	p.R10Q	2
MRPS7	SKCM	chr17	73259559	73259559	C	T	Missense_Mutation	p.P160S	2
MRPS7	HNSC	chr17	73258060	73258060	C	G	Missense_Mutation	p.P27A	2
MRPS7	UCEC	chr17	73258940	73258940	A	G	Missense_Mutation	p.M111V	2
MRPS7	BLCA	chr17	73258675	73258675	G	A	Missense_Mutation	p.E61K	2
MRPS7	BLCA	chr17	73261831	73261834	TGGA	-	Frame_Shift_Del	p.WM215fs	1
MRPS7	LIHC	chr17	73257989	73257989	C	-	Frame_Shift_Del	p.A3fs	1
MRPS7	ESCA	chr17	73258675	73258675	G	T	Nonsense_Mutation	p.E61X	1
MRPS7	SKCM	chr17	73258479	73258479	C	T	Silent	p.S24S	1
MRPS7	LGG	chr17	73258020	73258020	G	A	Silent	p.S13S	1
MRPS7	BLCA	chr17	73258495	73258506	TGGCAGTCATGC	-	In_Frame_Del	p.WQSC30del	1
MRPS7	LIHC	chr17	73261855	73261855	A	-	Frame_Shift_Del	p.K224fs	1
MRPS7	ESCA	chr17	73258925	73258925	C	T	Silent	p.L106L	1
MRPS7	LGG	chr17	73258504	73258504	T	C	Missense_Mutation	p.C33R	1
MRPS7	LUAD	chr17	73261910	73261910	C	T	Missense_Mutation	p.A241V	1
MRPS7	GBM	chr17	73258761	73258761	A	T	Silent	p.P89P	1
MRPS7	THCA	chr17	73258691	73258691	G	T	Missense_Mutation		1
MRPS7	LGG	chr17	73261787	73261787	C	A	Missense_Mutation	p.P200H	1
MRPS7	LUAD	chr17	73261994	73261994	G	A	Missense_Mutation	p.R269H	1
MRPS7	GBM	chr17	73258939	73258939	C	T	Silent	p.L110L	1
MRPS7	THYM	chr17	73258007	73258007	C	G	Missense_Mutation		1
MRPS7	BLCA	chr17	73261831	73261834	TGGA	-	Frame_Shift_Del		1
MRPS7	LGG	chr17	73258623	73258623	T	G	Missense_Mutation	p.D43E	1
MRPS7	LUAD	chr17	73258723	73258723	G	C	Missense_Mutation	p.A77P	1
MRPS7	GBM	chr17	73258939	73258939	C	T	Silent		1
MRPS7	THYM	chr17	73261899	73261899	G	T	Missense_Mutation		1
MRPS7	BLCA	chr17	73258675	73258675	G	A	Missense_Mutation		1
MRPS7	LGG	chr17	73258623	73258623	T	G	Missense_Mutation		1
MRPS7	LUAD	chr17	73258564	73258565	-	C	Frame_Shift_Ins	p.P53fs	1
MRPS7	HNSC	chr17	73258060	73258060	C	G	Missense_Mutation		1
MRPS7	BLCA	chr17	73258495	73258506	TGGCAGTCATGC	-	In_Frame_Del		1
MRPS7	LGG	chr17	73261787	73261787	C	A	Missense_Mutation		1
MRPS7	CESC	chr17	73257931	73257931	C	T	Missense_Mutation		1
MRPS7	LUAD	chr17	73261910	73261910	C	T	Missense_Mutation	p.A212V	1
MRPS7	HNSC	chr17	73258704	73258704	G	A	Silent		1
MRPS7	BLCA	chr17	73261875	73261875	G	A	Silent		1
MRPS7	LIHC	chr17	73259591	73259591	G	A	Silent		1
MRPS7	HNSC	chr17	73258704	73258704	G	A	Silent	p.K70K	1
MRPS7	LIHC	chr17	73258760	73258760	C	A	Missense_Mutation		1
MRPS7	COAD	chr17	73258685	73258685	A	G	Missense_Mutation	p.Y64C	1
MRPS7	LIHC	chr17	73258604	73258604	A	G	Missense_Mutation	p.Y37C	1
MRPS7	COAD	chr17	73258737	73258737	A	C	Missense_Mutation	p.K81N	1
MRPS7	SKCM	chr17	73258561	73258561	C	T	Missense_Mutation	p.L52F	1
MRPS7	KIRC	chr17	73258639	73258639	G	C	Missense_Mutation	p.E49Q	1
MRPS7	UCS	chr17	73258657	73258657	G	C	Missense_Mutation		1
MRPS7	BLCA	chr17	73261875	73261875	G	A	Silent	p.L229L	1
MRPS7	LIHC	chr17	73259529	73259529	A	-	Frame_Shift_Del	p.K150fs	1
MRPS7	COAD	chr17	73259484	73259484	G	A	Missense_Mutation	p.A135T	1
MRPS7	SKCM	chr17	73258480	73258480	C	T	Missense_Mutation	p.P25S	1
MRPS7	KIRC	chr17	73258412	73258412	C	T	Missense_Mutation	p.S2F	1
MRPS7	UCS	chr17	73259478	73259478	G	A	Missense_Mutation		1

Copy number variation (CNV) of MRPS7
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS7
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
55231	STAD	TCGA-BR-A4CR	ARMC7	chr17	73106701	+	MRPS7	chr17	73261782	+
55231	ESCA	TCGA-VR-A8EW	DDX5	chr17	62502193	-	MRPS7	chr17	73258577	+
82318	LUAD	TCGA-91-8499-01A	MRPS7	chr17	73259588	+	GGA3	chr17	73242877	-
55232	N/A	BU676688	MRPS7	chr17	73262210	-	MRPS7	chr17	73262027	+
88094	LUSC	TCGA-22-4607-01A	MRPS7	chr17	73259588	+	SLC16A5	chr17	73096102	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	MRPS7	0.00147870273638824	0.041
KIRP	MRPS7	0.00764493230059306	0.21
BRCA	MRPS7	0.00808496960395095	0.21

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPS7	0.0227317097064907	0.7
THCA	MRPS7	0.00157361449136968	0.05
KIRC	MRPS7	0.000534444636171319	0.018
LGG	MRPS7	0.0370407046166092	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4693450	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 34	1	GENOMICS_ENGLAND;ORPHANET;UNIPROT
C4704874	Mammary Carcinoma, Human	1	CTD_human