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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL51 (NCBI Gene ID:51258)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL51
	Gene ID: 51258
	Gene Symbol	MRPL51
	Gene ID	51258
	Gene Name	mitochondrial ribosomal protein L51
	Synonyms	CDA09\|HSPC241\|MRP64\|bMRP64
	Cytomap	12p13.31
	Type of Gene	protein-coding
	Description	39S ribosomal protein L51, mitochondrialL51mtMRP-L51bMRP-64mitochondrial large ribosomal subunit protein mL51mitochondrial ribosomal protein 64mitochondrial ribosomal protein bMRP64
	Modification date	20200313
	UniProtAcc	Q4U2R6

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL51	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'MRPL51[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL51	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	MRPL51	-1.32840656722761	0.000213860534131527
COAD	MRPL51	-1.84147877110728	0.0110453069210053
BRCA	MRPL51	-2.91631474502369	5.42627121034746e-18
KIRC	MRPL51	-1.59773648669469	8.46797387064351e-07
LUAD	MRPL51	-1.44585271087263	9.92276876427582e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
GBM	MRPL51	0.290279598	0.012872319
LGG	MRPL51	0.144361903	0.023439991
CHOL	MRPL51	-0.070368662	0.043348194

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL51 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MRPL51	IDH3B	0.800854554	8.25E-12
DLBC	Cell metabolism gene	MRPL51	PGP	0.807910123	3.91E-12
DLBC	Cell metabolism gene	MRPL51	FPGS	0.809094147	3.44E-12
DLBC	Cell metabolism gene	MRPL51	TIMM8B	0.80988085	3.15E-12
DLBC	Cell metabolism gene	MRPL51	HSD17B10	0.813807538	2.04E-12
DLBC	Cell metabolism gene	MRPL51	TOMM22	0.813900921	2.02E-12
DLBC	Cell metabolism gene	MRPL51	LYPLA2	0.814298842	1.93E-12
DLBC	Cell metabolism gene	MRPL51	MIF	0.817214204	1.39E-12
DLBC	Cell metabolism gene	MRPL51	GFER	0.818031194	1.26E-12
DLBC	Cell metabolism gene	MRPL51	PSMB4	0.819827688	1.03E-12
DLBC	Cell metabolism gene	MRPL51	PTDSS2	0.820699513	9.28E-13
DLBC	Cell metabolism gene	MRPL51	PSMB7	0.82150192	8.45E-13
DLBC	Cell metabolism gene	MRPL51	PFDN5	0.821555851	8.40E-13
DLBC	Cell metabolism gene	MRPL51	SNRPD3	0.823881449	6.38E-13
DLBC	Cell metabolism gene	MRPL51	UROD	0.824203923	6.14E-13
DLBC	Cell metabolism gene	MRPL51	TIMM10	0.824225523	6.12E-13
DLBC	Cell metabolism gene	MRPL51	SEC61G	0.826757342	4.51E-13
DLBC	Cell metabolism gene	MRPL51	LSM4	0.829938739	3.06E-13
DLBC	Cell metabolism gene	MRPL51	ATP5G1	0.837028795	1.24E-13
DLBC	Cell metabolism gene	MRPL51	ITPA	0.837144359	1.23E-13
DLBC	Cell metabolism gene	MRPL51	POLR2F	0.841067262	7.31E-14
DLBC	Cell metabolism gene	MRPL51	B3GAT3	0.841668232	6.75E-14
DLBC	Cell metabolism gene	MRPL51	POLE4	0.842099723	6.37E-14
DLBC	Cell metabolism gene	MRPL51	EXOSC4	0.845480359	4.02E-14
DLBC	Cell metabolism gene	MRPL51	PSMA7	0.847924191	2.87E-14
DLBC	Cell metabolism gene	MRPL51	GEMIN7	0.848508553	2.64E-14
DLBC	Cell metabolism gene	MRPL51	SNRPB	0.849016566	2.46E-14
DLBC	Cell metabolism gene	MRPL51	NME2	0.849236157	2.38E-14
DLBC	Cell metabolism gene	MRPL51	PSMD4	0.849271365	2.37E-14
DLBC	Cell metabolism gene	MRPL51	FAU	0.850906959	1.88E-14
DLBC	Cell metabolism gene	MRPL51	ACOT8	0.852431012	1.51E-14
DLBC	Cell metabolism gene	MRPL51	TIMM50	0.852480623	1.50E-14
DLBC	Cell metabolism gene	MRPL51	DTYMK	0.853053883	1.38E-14
DLBC	Cell metabolism gene	MRPL51	POLR2I	0.85906204	5.65E-15
DLBC	Cell metabolism gene	MRPL51	TPI1	0.859496631	5.29E-15
DLBC	Cell metabolism gene	MRPL51	PSMC1	0.861689385	3.78E-15
DLBC	Cell metabolism gene	MRPL51	PSMC5	0.862828818	3.16E-15
DLBC	Cell metabolism gene	MRPL51	SNRPD2	0.864471897	2.44E-15
DLBC	Cell metabolism gene	MRPL51	POLR2L	0.876890837	3.08E-16
DLBC	Cell metabolism gene	MRPL51	TIMM13	0.883915825	8.62E-17
DLBC	Cell metabolism gene	MRPL51	PSMB6	0.888647714	3.49E-17
DLBC	Cell metabolism gene	MRPL51	PSMC3	0.892945211	1.48E-17
DLBC	Cell metabolism gene	MRPL51	PSMD13	0.894457347	1.08E-17
DLBC	Cell metabolism gene	MRPL51	PSMB3	0.916866562	5.74E-20
DLBC	CGC	MRPL51	TFPT	0.800772932	8.32E-12
DLBC	CGC	MRPL51	SDHAF2	0.807852391	3.93E-12
DLBC	CGC	MRPL51	HRAS	0.82663355	4.58E-13
DLBC	CGC	MRPL51	NTHL1	0.828042914	3.86E-13
DLBC	CGC	MRPL51	COX6C	0.842275192	6.22E-14
DLBC	Epifactor	MRPL51	TFPT	0.800772932	8.32E-12
DLBC	Epifactor	MRPL51	ZNHIT1	0.807891516	3.91E-12
DLBC	Epifactor	MRPL51	RUVBL2	0.809119743	3.43E-12
DLBC	Epifactor	MRPL51	PRPF31	0.814873356	1.81E-12
DLBC	Epifactor	MRPL51	FBL	0.815771133	1.64E-12
DLBC	Epifactor	MRPL51	SIRT6	0.830261517	2.94E-13
DLBC	Epifactor	MRPL51	DMAP1	0.832159123	2.32E-13
DLBC	Epifactor	MRPL51	ANP32B	0.838276419	1.06E-13
DLBC	Epifactor	MRPL51	EXOSC4	0.845480359	4.02E-14
DLBC	Epifactor	MRPL51	RBX1	0.850457753	2.01E-14
DLBC	Epifactor	MRPL51	MBD3	0.850738334	1.93E-14
DLBC	Epifactor	MRPL51	BRMS1	0.853395778	1.31E-14
DLBC	Epifactor	MRPL51	PPP4C	0.855318079	9.91E-15
DLBC	IUPHAR	MRPL51	SLC25A39	0.800892852	8.22E-12
DLBC	IUPHAR	MRPL51	SLC25A3	0.81918284	1.11E-12
DLBC	IUPHAR	MRPL51	HRAS	0.82663355	4.58E-13
DLBC	IUPHAR	MRPL51	SIRT6	0.830261517	2.94E-13
DLBC	IUPHAR	MRPL51	MFSD2B	0.83885862	9.80E-14
DLBC	IUPHAR	MRPL51	BIRC5	0.865500953	2.07E-15
DLBC	IUPHAR	MRPL51	PSMB6	0.888647714	3.49E-17
DLBC	TF	MRPL51	THAP3	0.802189402	7.18E-12
DLBC	TF	MRPL51	THAP4	0.814245433	1.94E-12
DLBC	TF	MRPL51	NME2	0.849236157	2.38E-14
DLBC	TF	MRPL51	MBD3	0.850738334	1.93E-14
DLBC	TF	MRPL51	PIN1	0.864629934	2.38E-15
DLBC	TSG	MRPL51	TSSC4	0.82898949	3.44E-13
DLBC	TSG	MRPL51	SIRT6	0.830261517	2.94E-13
DLBC	TSG	MRPL51	PARK7	0.83047782	2.86E-13
DLBC	TSG	MRPL51	PHB	0.843175062	5.51E-14
DLBC	TSG	MRPL51	BRMS1	0.853395778	1.31E-14
DLBC	TSG	MRPL51	PIN1	0.864629934	2.38E-15
DLBC	TSG	MRPL51	GADD45GIP1	0.898096703	5.04E-18
ESCA	Cell metabolism gene	MRPL51	TPI1	0.80589339	4.89E-46
GBM	Epifactor	MRPL51	DPY30	0.803082074	4.52E-40
KIRP	Cell metabolism gene	MRPL51	PFDN5	0.811447405	7.22E-77
KIRP	TSG	MRPL51	DIABLO	0.807574387	1.34E-75
LUSC	Cell metabolism gene	MRPL51	TPI1	0.804762293	6.59E-127
PRAD	TSG	MRPL51	GADD45GIP1	0.800644233	5.18E-124
TGCT	Cell metabolism gene	MRPL51	MGST1	0.800428456	4.72E-36
TGCT	Cell metabolism gene	MRPL51	PDHA1	0.801846563	2.89E-36
TGCT	Cell metabolism gene	MRPL51	GLO1	0.810417466	1.37E-37
TGCT	Cell metabolism gene	MRPL51	AK2	0.816895464	1.23E-38
TGCT	Cell metabolism gene	MRPL51	MED30	0.818525523	6.61E-39
TGCT	Cell metabolism gene	MRPL51	TPI1	0.825182599	4.89E-40
TGCT	Epifactor	MRPL51	EHMT2	0.801915343	2.82E-36
TGCT	IUPHAR	MRPL51	EHMT2	0.801915343	2.82E-36
TGCT	TSG	MRPL51	ERRFI1	0.81544402	2.13E-38
THCA	Cell metabolism gene	MRPL51	APRT	0.800945544	4.41E-129
THCA	Cell metabolism gene	MRPL51	PSMD9	0.802751577	4.36E-130
THCA	Cell metabolism gene	MRPL51	LSM2	0.807512216	8.70E-133
THCA	Cell metabolism gene	MRPL51	PSMC5	0.811053987	7.60E-135
THCA	Cell metabolism gene	MRPL51	PSMB7	0.812912516	6.07E-136
THCA	Cell metabolism gene	MRPL51	SNRPD2	0.82044831	1.60E-140
THCA	Cell metabolism gene	MRPL51	PSMC1	0.822510124	8.20E-142
THCA	Cell metabolism gene	MRPL51	PSMB1	0.826753903	1.60E-144
THCA	Cell metabolism gene	MRPL51	LSM4	0.827946354	2.69E-145
THCA	Cell metabolism gene	MRPL51	TIMM8B	0.829408641	2.96E-146
THCA	Cell metabolism gene	MRPL51	PSMB3	0.833092094	1.04E-148
THCA	Cell metabolism gene	MRPL51	POLR2L	0.833779561	3.56E-149
THCA	Cell metabolism gene	MRPL51	PSMB6	0.874556078	2.61E-181
THCA	Epifactor	MRPL51	BRMS1	0.802778333	4.21E-130
THCA	IUPHAR	MRPL51	PPIA	0.820889611	8.50E-141
THCA	IUPHAR	MRPL51	PSMB1	0.826753903	1.60E-144
THCA	IUPHAR	MRPL51	PSMB6	0.874556078	2.61E-181
THCA	TSG	MRPL51	BRMS1	0.802778333	4.21E-130
THCA	TSG	MRPL51	STUB1	0.811618066	3.54E-135
THYM	Cell metabolism gene	MRPL51	POLR2F	0.801018749	1.64E-28
THYM	Cell metabolism gene	MRPL51	DAD1	0.803154445	9.21E-29
THYM	Cell metabolism gene	MRPL51	AAAS	0.804199522	6.92E-29
THYM	Cell metabolism gene	MRPL51	TPI1	0.804400931	6.55E-29
THYM	Cell metabolism gene	MRPL51	GCDH	0.805017593	5.53E-29
THYM	Cell metabolism gene	MRPL51	GMPPA	0.805341796	5.05E-29
THYM	Cell metabolism gene	MRPL51	DOHH	0.80542838	4.93E-29
THYM	Cell metabolism gene	MRPL51	NUDT2	0.807064856	3.13E-29
THYM	Cell metabolism gene	MRPL51	CCT7	0.809022172	1.81E-29
THYM	Cell metabolism gene	MRPL51	SUCLG1	0.810614577	1.15E-29
THYM	Cell metabolism gene	MRPL51	PSMB4	0.811486268	8.97E-30
THYM	Cell metabolism gene	MRPL51	EXOSC1	0.811601614	8.68E-30
THYM	Cell metabolism gene	MRPL51	FDPS	0.811654638	8.55E-30
THYM	Cell metabolism gene	MRPL51	POLA2	0.811733036	8.36E-30
THYM	Cell metabolism gene	MRPL51	DHRS4L2	0.815090836	3.16E-30
THYM	Cell metabolism gene	MRPL51	FAU	0.815258631	3.01E-30
THYM	Cell metabolism gene	MRPL51	UROS	0.815439394	2.85E-30
THYM	Cell metabolism gene	MRPL51	EXOSC5	0.81649206	2.09E-30
THYM	Cell metabolism gene	MRPL51	PREB	0.817077351	1.76E-30
THYM	Cell metabolism gene	MRPL51	SNRPD3	0.81939272	8.83E-31
THYM	Cell metabolism gene	MRPL51	GSS	0.820693552	5.96E-31
THYM	Cell metabolism gene	MRPL51	PFDN5	0.821655448	4.45E-31
THYM	Cell metabolism gene	MRPL51	POLD4	0.823382977	2.62E-31
THYM	Cell metabolism gene	MRPL51	HMOX2	0.825037618	1.57E-31
THYM	Cell metabolism gene	MRPL51	DPM2	0.825445042	1.38E-31
THYM	Cell metabolism gene	MRPL51	HMBS	0.825725167	1.27E-31
THYM	Cell metabolism gene	MRPL51	TALDO1	0.826114317	1.12E-31
THYM	Cell metabolism gene	MRPL51	SEC61B	0.826834664	8.95E-32
THYM	Cell metabolism gene	MRPL51	PSMB10	0.833668271	9.92E-33
THYM	Cell metabolism gene	MRPL51	ATP5G1	0.834201831	8.32E-33
THYM	Cell metabolism gene	MRPL51	NME1	0.834765171	6.91E-33
THYM	Cell metabolism gene	MRPL51	SNRPF	0.835034108	6.32E-33
THYM	Cell metabolism gene	MRPL51	POLR2J	0.835063707	6.26E-33
THYM	Cell metabolism gene	MRPL51	FPGS	0.83571825	5.03E-33
THYM	Cell metabolism gene	MRPL51	PSMB1	0.835951649	4.65E-33
THYM	Cell metabolism gene	MRPL51	PSMA7	0.836260698	4.20E-33
THYM	Cell metabolism gene	MRPL51	PGLS	0.836355605	4.06E-33
THYM	Cell metabolism gene	MRPL51	MED19	0.836390357	4.02E-33
THYM	Cell metabolism gene	MRPL51	SSR2	0.836545397	3.81E-33
THYM	Cell metabolism gene	MRPL51	PSMA6	0.836861413	3.43E-33
THYM	Cell metabolism gene	MRPL51	TXN	0.83887904	1.73E-33
THYM	Cell metabolism gene	MRPL51	PSMC5	0.840323091	1.06E-33
THYM	Cell metabolism gene	MRPL51	HSD17B10	0.841374988	7.34E-34
THYM	Cell metabolism gene	MRPL51	POLR2I	0.842629636	4.74E-34
THYM	Cell metabolism gene	MRPL51	TBCB	0.843422693	3.59E-34
THYM	Cell metabolism gene	MRPL51	MTX1	0.844855555	2.16E-34
THYM	Cell metabolism gene	MRPL51	MVD	0.849964339	3.41E-35
THYM	Cell metabolism gene	MRPL51	GEMIN6	0.850466434	2.83E-35
THYM	Cell metabolism gene	MRPL51	PMPCA	0.851000347	2.32E-35
THYM	Cell metabolism gene	MRPL51	TOMM22	0.851140652	2.20E-35
THYM	Cell metabolism gene	MRPL51	WBSCR22	0.851934389	1.64E-35
THYM	Cell metabolism gene	MRPL51	PSMD9	0.853015188	1.09E-35
THYM	Cell metabolism gene	MRPL51	LSM5	0.856968179	2.41E-36
THYM	Cell metabolism gene	MRPL51	TIMM10	0.857323963	2.10E-36
THYM	Cell metabolism gene	MRPL51	IDH3B	0.857451462	1.99E-36
THYM	Cell metabolism gene	MRPL51	PSME1	0.858814977	1.17E-36
THYM	Cell metabolism gene	MRPL51	PHKG2	0.861577079	3.89E-37
THYM	Cell metabolism gene	MRPL51	PAFAH1B3	0.863301463	1.94E-37
THYM	Cell metabolism gene	MRPL51	PSMB2	0.863314923	1.93E-37
THYM	Cell metabolism gene	MRPL51	PSMC1	0.864202718	1.34E-37
THYM	Cell metabolism gene	MRPL51	PSMD8	0.865730589	7.12E-38
THYM	Cell metabolism gene	MRPL51	ITPA	0.866147905	5.98E-38
THYM	Cell metabolism gene	MRPL51	NOP56	0.866629705	4.89E-38
THYM	Cell metabolism gene	MRPL51	NANS	0.866807696	4.54E-38
THYM	Cell metabolism gene	MRPL51	PSMA4	0.871555404	5.96E-39
THYM	Cell metabolism gene	MRPL51	OAZ1	0.872943753	3.24E-39
THYM	Cell metabolism gene	MRPL51	GEMIN7	0.872993349	3.17E-39
THYM	Cell metabolism gene	MRPL51	PSMA5	0.87389206	2.13E-39
THYM	Cell metabolism gene	MRPL51	PGP	0.874044423	1.99E-39
THYM	Cell metabolism gene	MRPL51	TIMM17B	0.874065555	1.97E-39
THYM	Cell metabolism gene	MRPL51	TOMM40	0.874899934	1.36E-39
THYM	Cell metabolism gene	MRPL51	GALK1	0.874963759	1.32E-39
THYM	Cell metabolism gene	MRPL51	POLR3K	0.877101976	5.00E-40
THYM	Cell metabolism gene	MRPL51	DGUOK	0.877958373	3.38E-40
THYM	Cell metabolism gene	MRPL51	APRT	0.879135303	1.96E-40
THYM	Cell metabolism gene	MRPL51	POLD2	0.880468055	1.05E-40
THYM	Cell metabolism gene	MRPL51	GUK1	0.881042155	8.00E-41
THYM	Cell metabolism gene	MRPL51	TIMM50	0.882066075	4.91E-41
THYM	Cell metabolism gene	MRPL51	PSMB6	0.884740926	1.35E-41
THYM	Cell metabolism gene	MRPL51	PSMD4	0.885227972	1.06E-41
THYM	Cell metabolism gene	MRPL51	LSM2	0.885349	9.99E-42
THYM	Cell metabolism gene	MRPL51	EXOSC4	0.890625162	6.95E-43
THYM	Cell metabolism gene	MRPL51	EBP	0.893745182	1.35E-43
THYM	Cell metabolism gene	MRPL51	SNRPD1	0.894458121	9.20E-44
THYM	Cell metabolism gene	MRPL51	SNRPB	0.898787295	8.50E-45
THYM	Cell metabolism gene	MRPL51	SLC27A5	0.899800883	4.79E-45
THYM	Cell metabolism gene	MRPL51	POLR2H	0.902712273	8.93E-46
THYM	Cell metabolism gene	MRPL51	SNRPE	0.904456082	3.18E-46
THYM	Cell metabolism gene	MRPL51	LSM3	0.906946494	7.04E-47
THYM	Cell metabolism gene	MRPL51	SEC61G	0.909887411	1.12E-47
THYM	Cell metabolism gene	MRPL51	LSM4	0.916536677	1.38E-49
THYM	Cell metabolism gene	MRPL51	PSMD13	0.920252665	1.00E-50
THYM	Cell metabolism gene	MRPL51	TIMM13	0.921457725	4.17E-51
THYM	Cell metabolism gene	MRPL51	DTYMK	0.922106486	2.59E-51
THYM	Cell metabolism gene	MRPL51	ACOT8	0.92269798	1.67E-51
THYM	Cell metabolism gene	MRPL51	PSMB7	0.926810765	7.10E-53
THYM	Cell metabolism gene	MRPL51	PSMB3	0.927290224	4.85E-53
THYM	Cell metabolism gene	MRPL51	TIMM8B	0.931336349	1.77E-54
THYM	Cell metabolism gene	MRPL51	SNRPD2	0.935101904	6.70E-56
THYM	Cell metabolism gene	MRPL51	PSMC3	0.937386535	8.36E-57
THYM	CGC	MRPL51	BAX	0.824726315	1.73E-31
THYM	CGC	MRPL51	CDK4	0.829808617	3.48E-32
THYM	CGC	MRPL51	RBM10	0.83315782	1.17E-32
THYM	CGC	MRPL51	COX6C	0.849545748	3.97E-35
THYM	CGC	MRPL51	TFPT	0.892177354	3.09E-43
THYM	CGC	MRPL51	SDHAF2	0.915523529	2.76E-49
THYM	Epifactor	MRPL51	NOC2L	0.801803587	1.33E-28
THYM	Epifactor	MRPL51	NAP1L4	0.808806829	1.92E-29
THYM	Epifactor	MRPL51	EXOSC1	0.811601614	8.68E-30
THYM	Epifactor	MRPL51	ZGPAT	0.813808279	4.59E-30
THYM	Epifactor	MRPL51	EXOSC5	0.81649206	2.09E-30
THYM	Epifactor	MRPL51	TRIM28	0.823963608	2.19E-31
THYM	Epifactor	MRPL51	PAF1	0.826597824	9.65E-32
THYM	Epifactor	MRPL51	LAS1L	0.827355547	7.60E-32
THYM	Epifactor	MRPL51	MBD3	0.831821779	1.82E-32
THYM	Epifactor	MRPL51	PRMT1	0.833928927	9.11E-33
THYM	Epifactor	MRPL51	ENY2	0.838133675	2.23E-33
THYM	Epifactor	MRPL51	MCRS1	0.840217309	1.10E-33
THYM	Epifactor	MRPL51	CDK5	0.85051712	2.78E-35
THYM	Epifactor	MRPL51	C17orf49	0.853369913	9.55E-36
THYM	Epifactor	MRPL51	ZNHIT1	0.857645922	1.85E-36
THYM	Epifactor	MRPL51	TAF10	0.861771725	3.60E-37
THYM	Epifactor	MRPL51	FBL	0.867538322	3.34E-38
THYM	Epifactor	MRPL51	PPM1G	0.872027439	4.85E-39
THYM	Epifactor	MRPL51	RRP8	0.87498196	1.31E-39
THYM	Epifactor	MRPL51	SIRT6	0.877787025	3.65E-40
THYM	Epifactor	MRPL51	PRPF31	0.884729433	1.35E-41
THYM	Epifactor	MRPL51	EXOSC4	0.890625162	6.95E-43
THYM	Epifactor	MRPL51	TFPT	0.892177354	3.09E-43
THYM	Epifactor	MRPL51	RUVBL2	0.893580776	1.47E-43
THYM	Epifactor	MRPL51	BRMS1	0.907638662	4.59E-47
THYM	Epifactor	MRPL51	PPP4C	0.910517133	7.50E-48
THYM	IUPHAR	MRPL51	USP5	0.80683579	3.34E-29
THYM	IUPHAR	MRPL51	EGLN2	0.809663714	1.51E-29
THYM	IUPHAR	MRPL51	UCHL3	0.810340529	1.24E-29
THYM	IUPHAR	MRPL51	FDPS	0.811654638	8.55E-30
THYM	IUPHAR	MRPL51	DYRK4	0.8214361	4.76E-31
THYM	IUPHAR	MRPL51	TRIM28	0.823963608	2.19E-31
THYM	IUPHAR	MRPL51	MFSD2B	0.824312117	1.97E-31
THYM	IUPHAR	MRPL51	HMOX2	0.825037618	1.57E-31
THYM	IUPHAR	MRPL51	CDK4	0.829808617	3.48E-32
THYM	IUPHAR	MRPL51	PRMT1	0.833928927	9.11E-33
THYM	IUPHAR	MRPL51	MPDU1	0.834213027	8.29E-33
THYM	IUPHAR	MRPL51	STK16	0.835098951	6.18E-33
THYM	IUPHAR	MRPL51	PSMB1	0.835951649	4.65E-33
THYM	IUPHAR	MRPL51	ECE2	0.84181818	6.29E-34
THYM	IUPHAR	MRPL51	MVD	0.849964339	3.41E-35
THYM	IUPHAR	MRPL51	CDK5	0.85051712	2.78E-35
THYM	IUPHAR	MRPL51	PPIA	0.855524752	4.20E-36
THYM	IUPHAR	MRPL51	PHKG2	0.861577079	3.89E-37
THYM	IUPHAR	MRPL51	PSMB2	0.863314923	1.93E-37
THYM	IUPHAR	MRPL51	SIRT6	0.877787025	3.65E-40
THYM	IUPHAR	MRPL51	PSMB6	0.884740926	1.35E-41
THYM	IUPHAR	MRPL51	SLC27A5	0.899800883	4.79E-45
THYM	Kinase	MRPL51	DYRK4	0.8214361	4.76E-31
THYM	Kinase	MRPL51	TRIM28	0.823963608	2.19E-31
THYM	Kinase	MRPL51	CDK4	0.829808617	3.48E-32
THYM	Kinase	MRPL51	STK16	0.835098951	6.18E-33
THYM	Kinase	MRPL51	ADCK4	0.843144795	3.96E-34
THYM	Kinase	MRPL51	CDK5	0.85051712	2.78E-35
THYM	Kinase	MRPL51	PHKG2	0.861577079	3.89E-37
THYM	TF	MRPL51	ZNF32	0.805261318	5.17E-29
THYM	TF	MRPL51	ETV2	0.810101185	1.33E-29
THYM	TF	MRPL51	GTF3A	0.81343784	5.12E-30
THYM	TF	MRPL51	ZGPAT	0.813808279	4.59E-30
THYM	TF	MRPL51	PREB	0.817077351	1.76E-30
THYM	TF	MRPL51	DRAP1	0.82738768	7.52E-32
THYM	TF	MRPL51	MBD3	0.831821779	1.82E-32
THYM	TF	MRPL51	RBCK1	0.83395968	9.01E-33
THYM	TF	MRPL51	ZNF668	0.834385722	7.83E-33
THYM	TF	MRPL51	THYN1	0.835001105	6.39E-33
THYM	TF	MRPL51	DNTTIP1	0.83571682	5.03E-33
THYM	TF	MRPL51	ZNF444	0.836904323	3.38E-33
THYM	TF	MRPL51	USF1	0.838710639	1.83E-33
THYM	TF	MRPL51	ZNF428	0.838805078	1.78E-33
THYM	TF	MRPL51	ZNF688	0.84387978	3.06E-34
THYM	TF	MRPL51	ZNF787	0.847150695	9.51E-35
THYM	TF	MRPL51	PIN1	0.866775065	4.60E-38
THYM	TSG	MRPL51	GABARAP	0.807462328	2.80E-29
THYM	TSG	MRPL51	GNB2L1	0.808620679	2.02E-29
THYM	TSG	MRPL51	AIP	0.809851596	1.43E-29
THYM	TSG	MRPL51	HTRA2	0.812362679	6.98E-30
THYM	TSG	MRPL51	BAX	0.824726315	1.73E-31
THYM	TSG	MRPL51	ZNF668	0.834385722	7.83E-33
THYM	TSG	MRPL51	NPRL2	0.834420615	7.74E-33
THYM	TSG	MRPL51	NME1	0.834765171	6.91E-33
THYM	TSG	MRPL51	DIABLO	0.835021683	6.34E-33
THYM	TSG	MRPL51	PARK7	0.835170105	6.04E-33
THYM	TSG	MRPL51	PFN1	0.835781686	4.92E-33
THYM	TSG	MRPL51	GADD45GIP1	0.84441	2.53E-34
THYM	TSG	MRPL51	PIN1	0.866775065	4.60E-38
THYM	TSG	MRPL51	SIRT6	0.877787025	3.65E-40
THYM	TSG	MRPL51	TSSC4	0.882223838	4.56E-41
THYM	TSG	MRPL51	BRMS1	0.907638662	4.59E-47
UCEC	Cell metabolism gene	MRPL51	TPI1	0.808444702	1.08E-47
UCS	Cell metabolism gene	MRPL51	POLR2F	0.801018749	1.64E-28
UCS	Cell metabolism gene	MRPL51	DAD1	0.803154445	9.21E-29
UCS	Cell metabolism gene	MRPL51	AAAS	0.804199522	6.92E-29
UCS	Cell metabolism gene	MRPL51	TPI1	0.804400931	6.55E-29
UCS	Cell metabolism gene	MRPL51	GCDH	0.805017593	5.53E-29
UCS	Cell metabolism gene	MRPL51	GMPPA	0.805341796	5.05E-29
UCS	Cell metabolism gene	MRPL51	DOHH	0.80542838	4.93E-29
UCS	Cell metabolism gene	MRPL51	NUDT2	0.807064856	3.13E-29
UCS	Cell metabolism gene	MRPL51	CCT7	0.809022172	1.81E-29
UCS	Cell metabolism gene	MRPL51	SUCLG1	0.810614577	1.15E-29
UCS	Cell metabolism gene	MRPL51	PSMB4	0.811486268	8.97E-30
UCS	Cell metabolism gene	MRPL51	EXOSC1	0.811601614	8.68E-30
UCS	Cell metabolism gene	MRPL51	FDPS	0.811654638	8.55E-30
UCS	Cell metabolism gene	MRPL51	POLA2	0.811733036	8.36E-30
UCS	Cell metabolism gene	MRPL51	DHRS4L2	0.815090836	3.16E-30
UCS	Cell metabolism gene	MRPL51	FAU	0.815258631	3.01E-30
UCS	Cell metabolism gene	MRPL51	UROS	0.815439394	2.85E-30
UCS	Cell metabolism gene	MRPL51	EXOSC5	0.81649206	2.09E-30
UCS	Cell metabolism gene	MRPL51	PREB	0.817077351	1.76E-30
UCS	Cell metabolism gene	MRPL51	SNRPD3	0.81939272	8.83E-31
UCS	Cell metabolism gene	MRPL51	GSS	0.820693552	5.96E-31
UCS	Cell metabolism gene	MRPL51	PFDN5	0.821655448	4.45E-31
UCS	Cell metabolism gene	MRPL51	POLD4	0.823382977	2.62E-31
UCS	Cell metabolism gene	MRPL51	HMOX2	0.825037618	1.57E-31
UCS	Cell metabolism gene	MRPL51	DPM2	0.825445042	1.38E-31
UCS	Cell metabolism gene	MRPL51	HMBS	0.825725167	1.27E-31
UCS	Cell metabolism gene	MRPL51	TALDO1	0.826114317	1.12E-31
UCS	Cell metabolism gene	MRPL51	SEC61B	0.826834664	8.95E-32
UCS	Cell metabolism gene	MRPL51	PSMB10	0.833668271	9.92E-33
UCS	Cell metabolism gene	MRPL51	ATP5G1	0.834201831	8.32E-33
UCS	Cell metabolism gene	MRPL51	NME1	0.834765171	6.91E-33
UCS	Cell metabolism gene	MRPL51	SNRPF	0.835034108	6.32E-33
UCS	Cell metabolism gene	MRPL51	POLR2J	0.835063707	6.26E-33
UCS	Cell metabolism gene	MRPL51	FPGS	0.83571825	5.03E-33
UCS	Cell metabolism gene	MRPL51	PSMB1	0.835951649	4.65E-33
UCS	Cell metabolism gene	MRPL51	PSMA7	0.836260698	4.20E-33
UCS	Cell metabolism gene	MRPL51	PGLS	0.836355605	4.06E-33
UCS	Cell metabolism gene	MRPL51	MED19	0.836390357	4.02E-33
UCS	Cell metabolism gene	MRPL51	SSR2	0.836545397	3.81E-33
UCS	Cell metabolism gene	MRPL51	PSMA6	0.836861413	3.43E-33
UCS	Cell metabolism gene	MRPL51	TXN	0.83887904	1.73E-33
UCS	Cell metabolism gene	MRPL51	PSMC5	0.840323091	1.06E-33
UCS	Cell metabolism gene	MRPL51	HSD17B10	0.841374988	7.34E-34
UCS	Cell metabolism gene	MRPL51	POLR2I	0.842629636	4.74E-34
UCS	Cell metabolism gene	MRPL51	TBCB	0.843422693	3.59E-34
UCS	Cell metabolism gene	MRPL51	MTX1	0.844855555	2.16E-34
UCS	Cell metabolism gene	MRPL51	MVD	0.849964339	3.41E-35
UCS	Cell metabolism gene	MRPL51	GEMIN6	0.850466434	2.83E-35
UCS	Cell metabolism gene	MRPL51	PMPCA	0.851000347	2.32E-35
UCS	Cell metabolism gene	MRPL51	TOMM22	0.851140652	2.20E-35
UCS	Cell metabolism gene	MRPL51	WBSCR22	0.851934389	1.64E-35
UCS	Cell metabolism gene	MRPL51	PSMD9	0.853015188	1.09E-35
UCS	Cell metabolism gene	MRPL51	LSM5	0.856968179	2.41E-36
UCS	Cell metabolism gene	MRPL51	TIMM10	0.857323963	2.10E-36
UCS	Cell metabolism gene	MRPL51	IDH3B	0.857451462	1.99E-36
UCS	Cell metabolism gene	MRPL51	PSME1	0.858814977	1.17E-36
UCS	Cell metabolism gene	MRPL51	PHKG2	0.861577079	3.89E-37
UCS	Cell metabolism gene	MRPL51	PAFAH1B3	0.863301463	1.94E-37
UCS	Cell metabolism gene	MRPL51	PSMB2	0.863314923	1.93E-37
UCS	Cell metabolism gene	MRPL51	PSMC1	0.864202718	1.34E-37
UCS	Cell metabolism gene	MRPL51	PSMD8	0.865730589	7.12E-38
UCS	Cell metabolism gene	MRPL51	ITPA	0.866147905	5.98E-38
UCS	Cell metabolism gene	MRPL51	NOP56	0.866629705	4.89E-38
UCS	Cell metabolism gene	MRPL51	NANS	0.866807696	4.54E-38
UCS	Cell metabolism gene	MRPL51	PSMA4	0.871555404	5.96E-39
UCS	Cell metabolism gene	MRPL51	OAZ1	0.872943753	3.24E-39
UCS	Cell metabolism gene	MRPL51	GEMIN7	0.872993349	3.17E-39
UCS	Cell metabolism gene	MRPL51	PSMA5	0.87389206	2.13E-39
UCS	Cell metabolism gene	MRPL51	PGP	0.874044423	1.99E-39
UCS	Cell metabolism gene	MRPL51	TIMM17B	0.874065555	1.97E-39
UCS	Cell metabolism gene	MRPL51	TOMM40	0.874899934	1.36E-39
UCS	Cell metabolism gene	MRPL51	GALK1	0.874963759	1.32E-39
UCS	Cell metabolism gene	MRPL51	POLR3K	0.877101976	5.00E-40
UCS	Cell metabolism gene	MRPL51	DGUOK	0.877958373	3.38E-40
UCS	Cell metabolism gene	MRPL51	APRT	0.879135303	1.96E-40
UCS	Cell metabolism gene	MRPL51	POLD2	0.880468055	1.05E-40
UCS	Cell metabolism gene	MRPL51	GUK1	0.881042155	8.00E-41
UCS	Cell metabolism gene	MRPL51	TIMM50	0.882066075	4.91E-41
UCS	Cell metabolism gene	MRPL51	PSMB6	0.884740926	1.35E-41
UCS	Cell metabolism gene	MRPL51	PSMD4	0.885227972	1.06E-41
UCS	Cell metabolism gene	MRPL51	LSM2	0.885349	9.99E-42
UCS	Cell metabolism gene	MRPL51	EXOSC4	0.890625162	6.95E-43
UCS	Cell metabolism gene	MRPL51	EBP	0.893745182	1.35E-43
UCS	Cell metabolism gene	MRPL51	SNRPD1	0.894458121	9.20E-44
UCS	Cell metabolism gene	MRPL51	SNRPB	0.898787295	8.50E-45
UCS	Cell metabolism gene	MRPL51	SLC27A5	0.899800883	4.79E-45
UCS	Cell metabolism gene	MRPL51	POLR2H	0.902712273	8.93E-46
UCS	Cell metabolism gene	MRPL51	SNRPE	0.904456082	3.18E-46
UCS	Cell metabolism gene	MRPL51	LSM3	0.906946494	7.04E-47
UCS	Cell metabolism gene	MRPL51	SEC61G	0.909887411	1.12E-47
UCS	Cell metabolism gene	MRPL51	LSM4	0.916536677	1.38E-49
UCS	Cell metabolism gene	MRPL51	PSMD13	0.920252665	1.00E-50
UCS	Cell metabolism gene	MRPL51	TIMM13	0.921457725	4.17E-51
UCS	Cell metabolism gene	MRPL51	DTYMK	0.922106486	2.59E-51
UCS	Cell metabolism gene	MRPL51	ACOT8	0.92269798	1.67E-51
UCS	Cell metabolism gene	MRPL51	PSMB7	0.926810765	7.10E-53
UCS	Cell metabolism gene	MRPL51	PSMB3	0.927290224	4.85E-53
UCS	Cell metabolism gene	MRPL51	TIMM8B	0.931336349	1.77E-54
UCS	Cell metabolism gene	MRPL51	SNRPD2	0.935101904	6.70E-56
UCS	Cell metabolism gene	MRPL51	PSMC3	0.937386535	8.36E-57
UCS	CGC	MRPL51	BAX	0.824726315	1.73E-31
UCS	CGC	MRPL51	CDK4	0.829808617	3.48E-32
UCS	CGC	MRPL51	RBM10	0.83315782	1.17E-32
UCS	CGC	MRPL51	COX6C	0.849545748	3.97E-35
UCS	CGC	MRPL51	TFPT	0.892177354	3.09E-43
UCS	CGC	MRPL51	SDHAF2	0.915523529	2.76E-49
UCS	Epifactor	MRPL51	NOC2L	0.801803587	1.33E-28
UCS	Epifactor	MRPL51	NAP1L4	0.808806829	1.92E-29
UCS	Epifactor	MRPL51	EXOSC1	0.811601614	8.68E-30
UCS	Epifactor	MRPL51	ZGPAT	0.813808279	4.59E-30
UCS	Epifactor	MRPL51	EXOSC5	0.81649206	2.09E-30
UCS	Epifactor	MRPL51	TRIM28	0.823963608	2.19E-31
UCS	Epifactor	MRPL51	PAF1	0.826597824	9.65E-32
UCS	Epifactor	MRPL51	LAS1L	0.827355547	7.60E-32
UCS	Epifactor	MRPL51	MBD3	0.831821779	1.82E-32
UCS	Epifactor	MRPL51	PRMT1	0.833928927	9.11E-33
UCS	Epifactor	MRPL51	ENY2	0.838133675	2.23E-33
UCS	Epifactor	MRPL51	MCRS1	0.840217309	1.10E-33
UCS	Epifactor	MRPL51	CDK5	0.85051712	2.78E-35
UCS	Epifactor	MRPL51	C17orf49	0.853369913	9.55E-36
UCS	Epifactor	MRPL51	ZNHIT1	0.857645922	1.85E-36
UCS	Epifactor	MRPL51	TAF10	0.861771725	3.60E-37
UCS	Epifactor	MRPL51	FBL	0.867538322	3.34E-38
UCS	Epifactor	MRPL51	PPM1G	0.872027439	4.85E-39
UCS	Epifactor	MRPL51	RRP8	0.87498196	1.31E-39
UCS	Epifactor	MRPL51	SIRT6	0.877787025	3.65E-40
UCS	Epifactor	MRPL51	PRPF31	0.884729433	1.35E-41
UCS	Epifactor	MRPL51	EXOSC4	0.890625162	6.95E-43
UCS	Epifactor	MRPL51	TFPT	0.892177354	3.09E-43
UCS	Epifactor	MRPL51	RUVBL2	0.893580776	1.47E-43
UCS	Epifactor	MRPL51	BRMS1	0.907638662	4.59E-47
UCS	Epifactor	MRPL51	PPP4C	0.910517133	7.50E-48
UCS	IUPHAR	MRPL51	USP5	0.80683579	3.34E-29
UCS	IUPHAR	MRPL51	EGLN2	0.809663714	1.51E-29
UCS	IUPHAR	MRPL51	UCHL3	0.810340529	1.24E-29
UCS	IUPHAR	MRPL51	FDPS	0.811654638	8.55E-30
UCS	IUPHAR	MRPL51	DYRK4	0.8214361	4.76E-31
UCS	IUPHAR	MRPL51	TRIM28	0.823963608	2.19E-31
UCS	IUPHAR	MRPL51	MFSD2B	0.824312117	1.97E-31
UCS	IUPHAR	MRPL51	HMOX2	0.825037618	1.57E-31
UCS	IUPHAR	MRPL51	CDK4	0.829808617	3.48E-32
UCS	IUPHAR	MRPL51	PRMT1	0.833928927	9.11E-33
UCS	IUPHAR	MRPL51	MPDU1	0.834213027	8.29E-33
UCS	IUPHAR	MRPL51	STK16	0.835098951	6.18E-33
UCS	IUPHAR	MRPL51	PSMB1	0.835951649	4.65E-33
UCS	IUPHAR	MRPL51	ECE2	0.84181818	6.29E-34
UCS	IUPHAR	MRPL51	MVD	0.849964339	3.41E-35
UCS	IUPHAR	MRPL51	CDK5	0.85051712	2.78E-35
UCS	IUPHAR	MRPL51	PPIA	0.855524752	4.20E-36
UCS	IUPHAR	MRPL51	PHKG2	0.861577079	3.89E-37
UCS	IUPHAR	MRPL51	PSMB2	0.863314923	1.93E-37
UCS	IUPHAR	MRPL51	SIRT6	0.877787025	3.65E-40
UCS	IUPHAR	MRPL51	PSMB6	0.884740926	1.35E-41
UCS	IUPHAR	MRPL51	SLC27A5	0.899800883	4.79E-45
UCS	Kinase	MRPL51	DYRK4	0.8214361	4.76E-31
UCS	Kinase	MRPL51	TRIM28	0.823963608	2.19E-31
UCS	Kinase	MRPL51	CDK4	0.829808617	3.48E-32
UCS	Kinase	MRPL51	STK16	0.835098951	6.18E-33
UCS	Kinase	MRPL51	ADCK4	0.843144795	3.96E-34
UCS	Kinase	MRPL51	CDK5	0.85051712	2.78E-35
UCS	Kinase	MRPL51	PHKG2	0.861577079	3.89E-37
UCS	TF	MRPL51	ZNF32	0.805261318	5.17E-29
UCS	TF	MRPL51	ETV2	0.810101185	1.33E-29
UCS	TF	MRPL51	GTF3A	0.81343784	5.12E-30
UCS	TF	MRPL51	ZGPAT	0.813808279	4.59E-30
UCS	TF	MRPL51	PREB	0.817077351	1.76E-30
UCS	TF	MRPL51	DRAP1	0.82738768	7.52E-32
UCS	TF	MRPL51	MBD3	0.831821779	1.82E-32
UCS	TF	MRPL51	RBCK1	0.83395968	9.01E-33
UCS	TF	MRPL51	ZNF668	0.834385722	7.83E-33
UCS	TF	MRPL51	THYN1	0.835001105	6.39E-33
UCS	TF	MRPL51	DNTTIP1	0.83571682	5.03E-33
UCS	TF	MRPL51	ZNF444	0.836904323	3.38E-33
UCS	TF	MRPL51	USF1	0.838710639	1.83E-33
UCS	TF	MRPL51	ZNF428	0.838805078	1.78E-33
UCS	TF	MRPL51	ZNF688	0.84387978	3.06E-34
UCS	TF	MRPL51	ZNF787	0.847150695	9.51E-35
UCS	TF	MRPL51	PIN1	0.866775065	4.60E-38
UCS	TSG	MRPL51	GABARAP	0.807462328	2.80E-29
UCS	TSG	MRPL51	GNB2L1	0.808620679	2.02E-29
UCS	TSG	MRPL51	AIP	0.809851596	1.43E-29
UCS	TSG	MRPL51	HTRA2	0.812362679	6.98E-30
UCS	TSG	MRPL51	BAX	0.824726315	1.73E-31
UCS	TSG	MRPL51	ZNF668	0.834385722	7.83E-33
UCS	TSG	MRPL51	NPRL2	0.834420615	7.74E-33
UCS	TSG	MRPL51	NME1	0.834765171	6.91E-33
UCS	TSG	MRPL51	DIABLO	0.835021683	6.34E-33
UCS	TSG	MRPL51	PARK7	0.835170105	6.04E-33
UCS	TSG	MRPL51	PFN1	0.835781686	4.92E-33
UCS	TSG	MRPL51	GADD45GIP1	0.84441	2.53E-34
UCS	TSG	MRPL51	PIN1	0.866775065	4.60E-38
UCS	TSG	MRPL51	SIRT6	0.877787025	3.65E-40
UCS	TSG	MRPL51	TSSC4	0.882223838	4.56E-41
UCS	TSG	MRPL51	BRMS1	0.907638662	4.59E-47

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	MRPL51	MRPL20	1.48585631024503	0.000111704804180407
KIRC	MRPL51	MRPL55	-1.02163441832258	0.000291940846845375
LUAD	MRPL51	MRPL20	-3.00071204707904	0.000452706327224566
BRCA	MRPL51	MRPL20	-1.74379528461375	0.000756034430433012
LUSC	MRPL51	MRPL39	-3.50411737429004	0.000985010025625636
COAD	MRPL51	MRPL41	-2.99561502382389	0.00144392251968384
ESCA	MRPL51	MRPL48	-2.17664297194246	0.0029296875
LUAD	MRPL51	MRPL48	-1.10341092084552	0.00317944105654513
CHOL	MRPL51	MRPL41	-4.96379377542225	0.00390625
BLCA	MRPL51	MRPL39	1.69896851960452	0.00391769409179688
LUAD	MRPL51	MRPL39	-1.1049452981592	0.00471395891927286
THCA	MRPL51	MRPL41	-3.88188543554269	0.00492925389458784
PRAD	MRPL51	ICT1	-1.54848444909352	0.00907723161841939
COAD	MRPL51	MRPL48	1.05473904000693	0.0101850330829621
LIHC	MRPL51	MRPL20	-1.08735154161025	0.0158079482509981
STAD	MRPL51	MRPL4	1.4393539135682	0.0279771662317216
COAD	MRPL51	MRPL39	-1.15285953291756	0.0357243716716767
KIRP	MRPL51	MRPL36	1.03588200500181	0.0433286507613957
BRCA	MRPL51	MRPL36	-1.94167827329593	1.14465421352297e-11
KIRP	MRPL51	MRPL49	-2.36524030474784	1.53668224811554e-08
BRCA	MRPL51	ICT1	-4.17488220449664	2.73719348917167e-14
COAD	MRPL51	MRPL4	2.77705897514473	2.98023223876954e-07
LUAD	MRPL51	MRPL36	-3.29841702586724	3.01758810775006e-09
PRAD	MRPL51	MRPL37	-2.21074342735295	3.65283830814974e-07
LUAD	MRPL51	MRPL37	-2.86549200993971	3.76287422734829e-10
LIHC	MRPL51	MRPL39	-1.65461683386216	3.95799979560965e-08
BRCA	MRPL51	MRPL48	-1.11598766368451	3.97642668731928e-05
PRAD	MRPL51	MRPL41	1.31179686307216	4.41809300064344e-05
THCA	MRPL51	MRPL49	-1.28871899028168	5.42468304941934e-06
BRCA	MRPL51	MRPL55	-1.64092910603924	6.01408870059924e-14
LUSC	MRPL51	ICT1	-3.23093376049456	6.60526357089358e-07
LUSC	MRPL51	MRPL55	-1.42665529836846	7.19742900589893e-05
LUAD	MRPL51	MRPL55	-2.50406829694459	7.3663238952828e-06
KICH	MRPL51	MRPL41	1.05103651319563	7.49826431274414e-05
BRCA	MRPL51	MRPL37	-3.79079551418026	9.33185484212232e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL51

OXA1L, ICT1, MRPL37, MRPL41, MRPL40, MRPL21, MRPL52, MRPL45, MRPL44, MRPL24, MRPL38, MRPL55, MRPL23, RPS18, TMEM177, HNRNPU, LAMTOR3, MPV17, RPS8, MRPL4, MRPL39, MRPS30, MRPL47, MRPL50, MRPL9, FOXB1, MRPL42, MRPL10, MRPL12, PDGFB, RPL18, ALYREF, SNRNP70, HSCB, AUH, C12orf65, C1QBP, C6orf203, GFM1, MDH2, METTL17, MRPL11, MTG1, MTIF3, MTRF1, MTRF1L, NGRN, PMPCB, TACO1, TBRG4, TRUB2, TSFM, TUFM, LDLR, H2AFB2, FEM1A, S100A2, RPL13A, RPL37, MRPL33, FAM120A, YBX2, RBMS2, MRPL2, MRPL17, YBX1, PIPSL, MRPL13, MRPL32, SRSF3, MRPL20, H1FNT, SRSF4, GADD45GIP1, MRPL16, FTL, RPS9, ZBTB47, PTCD1, MRPL1, UBAC1, MRPL30, RPL19, TIMM10B, MALSU1, MRPL15, MRPL27, MAGEA9, RPL6, PAFAH2, MRPL28, MRPL18, PRR3, RPL26, RPL27A, RPL17, MRPL53, PPP1R9B, MRPL35, MSI1, NUDT8, GNL3, RPL36AL, MRPL43, NEIL1, WBSCR16, RPUSD4, MCAT, YARS2, MRPS18A, MRPL46, RBMS3, RPL3, SRSF7, FASTKD2, MTERF3, MRPL19, MRPL3, RPUSD3, PSMG3, MRPL22, MRPL48, MRPL57, MRPL49, RPL13,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL51	BRCA	chr12	6601615	6601615	G	A	Missense_Mutation	p.P70L	6
MRPL51	KIRC	chr12	6602094	6602095	-	G	Frame_Shift_Ins	p.S42fs	3
MRPL51	PAAD	chr12	6601500	6601500	G	A	Silent	p.H108H	3
MRPL51	BRCA	chr12	6602122	6602122	G	T	Silent	p.I32	3
MRPL51	LGG	chr12	6601555	6601555	C	T	Missense_Mutation	p.R90H	3
MRPL51	SKCM	chr12	6601548	6601548	G	A	Silent	p.I92I	3
MRPL51	UCEC	chr12	6601486	6601486	C	T	Missense_Mutation	p.R113H	2
MRPL51	UCEC	chr12	6601586	6601586	G	T	Missense_Mutation	p.L80I	2
MRPL51	LIHC	chr12	6602118	6602118	T	C	Missense_Mutation	p.I34V	2
MRPL51	LIHC	chr12	6602067	6602067	T	-	Frame_Shift_Del	p.R51fs	2
MRPL51	STAD	chr12	6602054	6602054	C	A	Missense_Mutation	p.G55V	2
MRPL51	KIRC	chr12	6602132	6602132	G	C	Missense_Mutation	p.P29R	2
MRPL51	LUAD	chr12	6602071	6602071	C	G	Missense_Mutation	p.E49D	2
MRPL51	STAD	chr12	6602121	6602121	C	A	Missense_Mutation	p.G33C	2
MRPL51	TGCT	chr12	6601619	6601619	G	A	Missense_Mutation		2
MRPL51	PAAD	chr12	6601500	6601500	G	A	Silent		2
MRPL51	UCEC	chr12	6602094	6602095	-	G	Frame_Shift_Ins	p.P41fs	1
MRPL51	KIRP	chr12	6602256	6602256	C	A	Missense_Mutation		1
MRPL51	SARC	chr12	6601503	6601503	C	T	Silent		1
MRPL51	COAD	chr12	6601442	6601442	G	A	Nonsense_Mutation	p.R128X	1
MRPL51	LGG	chr12	6601513	6601513	G	A	Missense_Mutation	p.A104V	1
MRPL51	SARC	chr12	6602100	6602100	G	T	Missense_Mutation		1
MRPL51	DLBC	chr12	6601475	6601475	G	A	Missense_Mutation	p.L117F	1
MRPL51	HNSC	chr12	6602125	6602125	C	T	Silent		1
MRPL51	LGG	chr12	6601555	6601555	C	T	Missense_Mutation		1
MRPL51	SKCM	chr12	6601457	6601457	G	T	Silent	p.R123R	1
MRPL51	HNSC	chr12	6601546	6601546	C	T	Missense_Mutation		1
MRPL51	LIHC	chr12	6602118	6602118	T	C	Missense_Mutation		1
MRPL51	SKCM	chr12	6602082	6602082	G	A	Missense_Mutation	p.R46C	1
MRPL51	HNSC	chr12	6601546	6601546	C	T	Missense_Mutation	p.R93Q	1
MRPL51	SKCM	chr12	6602288	6602288	G	A	Silent	p.L5L	1
MRPL51	HNSC	chr12	6602125	6602125	C	T	Silent	p.L31L	1
MRPL51	BLCA	chr12	6601515	6601515	G	T	Missense_Mutation		1
MRPL51	KIRC	chr12	6602137	6602137	A	C	Silent	p.G27G	1
MRPL51	LUSC	chr12	6601442	6601442	G	A	Nonsense_Mutation	p.R128*	1
MRPL51	BLCA	chr12	6602077	6602077	C	T	Nonsense_Mutation	p.W47*	1
MRPL51	KIRC	chr12	6602137	6602137	A	C	Splice_Site	p.G27_splice	1

Copy number variation (CNV) of MRPL51
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL51
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100243	N/A	CB054594	CEP250	chr20	34068435	+	MRPL51	chr12	6601316	+
100243	LUSC	TCGA-56-8622-01A	ERC1	chr12	1100488	+	MRPL51	chr12	6602138	-
100243	LUSC	TCGA-56-8622-01A	ERC1	chr12	1100653	-	MRPL51	chr12	6602138	-
100243	SARC	TCGA-DX-A1KZ-01A	FBXL7	chr5	15500822	+	MRPL51	chr12	6602138	-
100243	OV	TCGA-04-1361	GAPDH	chr12	6643735	+	MRPL51	chr12	6602138	-
100243	N/A	AA872664	HRH1	chr3	11209833	-	MRPL51	chr12	6602976	-
100243	N/A	CA313587	MRPL51	chr12	6601453	+	MRPL51	chr12	6601595	-
101630	N/A	AK309775	MRPL51	chr12	6601611	-	SPTLC1	chr9	94830350	-
91974	N/A	BF675494	MRPL51	chr12	6602315	-	SRSF5	chr14	70238296	+
100243	N/A	AA906776	OSBPL10	chr3	31725260	+	MRPL51	chr12	6602979	-
100246	N/A	DB519674	YY1AP1	chr1	155629912	-	MRPL51	chr12	6601464	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MRPL51	0.00333907206206936	0.093
HNSC	MRPL51	0.00673050508725001	0.18
LUAD	MRPL51	0.00703217092340318	0.18
LIHC	MRPL51	0.0132873290454988	0.33
LUSC	MRPL51	0.0154532106063068	0.37
LGG	MRPL51	0.0201706190909185	0.46
ESCA	MRPL51	0.0213485650615479	0.47

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MRPL51	0.0210442536437195	0.63
LUSC	MRPL51	0.0228953152120677	0.66
KIRC	MRPL51	0.0198620949900804	0.62
OV	MRPL51	0.0146770011797339	0.47
UCEC	MRPL51	0.0233945438959781	0.66
ESCA	MRPL51	0.00218165975928226	0.072
THYM	MRPL51	0.033764471922719	0.91

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source