Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS17 (NCBI Gene ID:51373)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS17
	Gene ID: 51373
	Gene Symbol	MRPS17
	Gene ID	51373
	Gene Name	mitochondrial ribosomal protein S17
	Synonyms	HSPC011\|MRP-S17\|RPMS17\|S17mt
	Cytomap	7p11.2
	Type of Gene	protein-coding
	Description	28S ribosomal protein S17, mitochondrialmitochondrial small ribosomal subunit protein uS17m
	Modification date	20200313
	UniProtAcc	Q9Y2R5

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS17	(0 - 67.6]

Top

Translation Studies in PubMed

We searched PubMed using 'MRPS17[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS17	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	MRPS17	2.29816065811916	0.000112780019881286
KICH	MRPS17	-4.39178765556403	2.5629997253418e-06
LUAD	MRPS17	-5.25175810277568	4.19177862905507e-09

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CHOL	MRPS17	0.09331646	0.013281807
TGCT	MRPS17	0.089364013	0.020015012
ESCA	MRPS17	-0.130119834	0.025715951

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS17 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	MRPS17	GGCT	0.833885575	2.09E-86
COAD	Cell metabolism gene	MRPS17	LSM5	0.833945541	1.98E-86
COAD	Cell metabolism gene	MRPS17	CCT6A	0.835262976	6.05E-87
COAD	IUPHAR	MRPS17	GGCT	0.833885575	2.09E-86
COAD	IUPHAR	MRPS17	PPIA	0.8381281	4.42E-88
DLBC	Cell metabolism gene	MRPS17	PSMD13	0.801642355	7.60E-12
DLBC	Cell metabolism gene	MRPS17	SNRPD3	0.804036256	5.91E-12
DLBC	Cell metabolism gene	MRPS17	PFDN6	0.804512774	5.62E-12
DLBC	Cell metabolism gene	MRPS17	TIMM8A	0.805207768	5.22E-12
DLBC	Cell metabolism gene	MRPS17	EXOSC5	0.806434409	4.58E-12
DLBC	Cell metabolism gene	MRPS17	DTYMK	0.810271415	3.02E-12
DLBC	Cell metabolism gene	MRPS17	PSMC3	0.811494519	2.64E-12
DLBC	Cell metabolism gene	MRPS17	MDH2	0.812031904	2.49E-12
DLBC	Cell metabolism gene	MRPS17	PGP	0.813176012	2.19E-12
DLBC	Cell metabolism gene	MRPS17	MIF	0.814945574	1.80E-12
DLBC	Cell metabolism gene	MRPS17	PMPCA	0.815773672	1.64E-12
DLBC	Cell metabolism gene	MRPS17	PSMD4	0.818333574	1.22E-12
DLBC	Cell metabolism gene	MRPS17	MTX1	0.822139291	7.84E-13
DLBC	Cell metabolism gene	MRPS17	WBSCR22	0.824032859	6.26E-13
DLBC	Cell metabolism gene	MRPS17	ATP5G1	0.826514736	4.65E-13
DLBC	Cell metabolism gene	MRPS17	POLD2	0.832316074	2.27E-13
DLBC	Cell metabolism gene	MRPS17	TIMM8B	0.832454886	2.23E-13
DLBC	Cell metabolism gene	MRPS17	PSMB3	0.832695955	2.17E-13
DLBC	Cell metabolism gene	MRPS17	SNRPD2	0.833651296	1.92E-13
DLBC	Cell metabolism gene	MRPS17	EXOSC4	0.83443236	1.74E-13
DLBC	Cell metabolism gene	MRPS17	POLR2J	0.83630406	1.37E-13
DLBC	Cell metabolism gene	MRPS17	NME2	0.841329424	7.06E-14
DLBC	Cell metabolism gene	MRPS17	PTDSS2	0.851726989	1.67E-14
DLBC	Cell metabolism gene	MRPS17	POLR2I	0.852664966	1.46E-14
DLBC	Cell metabolism gene	MRPS17	SEC61G	0.857229268	7.46E-15
DLBC	Cell metabolism gene	MRPS17	POLR2L	0.858494766	6.16E-15
DLBC	Cell metabolism gene	MRPS17	TIMM50	0.867521133	1.50E-15
DLBC	Cell metabolism gene	MRPS17	SNRPE	0.868530656	1.27E-15
DLBC	Cell metabolism gene	MRPS17	POLR2F	0.878197435	2.44E-16
DLBC	Cell metabolism gene	MRPS17	TIMM13	0.881588904	1.33E-16
DLBC	CGC	MRPS17	COX6C	0.811539892	2.63E-12
DLBC	Epifactor	MRPS17	ZNHIT1	0.800064756	8.96E-12
DLBC	Epifactor	MRPS17	EXOSC5	0.806434409	4.58E-12
DLBC	Epifactor	MRPS17	MBD3	0.816097974	1.58E-12
DLBC	Epifactor	MRPS17	FBL	0.833323263	2.00E-13
DLBC	Epifactor	MRPS17	EXOSC4	0.83443236	1.74E-13
DLBC	TF	MRPS17	MBD3	0.816097974	1.58E-12
DLBC	TF	MRPS17	NME2	0.841329424	7.06E-14
DLBC	TF	MRPS17	THAP4	0.861127017	4.12E-15
DLBC	TSG	MRPS17	TSSC4	0.805680137	4.96E-12
DLBC	TSG	MRPS17	PHB	0.845421052	4.06E-14
DLBC	TSG	MRPS17	GADD45GIP1	0.893662851	1.28E-17
HNSC	Cell metabolism gene	MRPS17	SEC61G	0.814486306	1.84E-135
KICH	Cell metabolism gene	MRPS17	AAAS	0.805800306	5.84E-22
KICH	Cell metabolism gene	MRPS17	SNRPB	0.815680821	7.20E-23
KICH	Cell metabolism gene	MRPS17	POLR2J	0.816026502	6.68E-23
KICH	Cell metabolism gene	MRPS17	SEC61G	0.830915206	2.21E-24
KICH	Cell metabolism gene	MRPS17	TOMM40	0.843604612	9.19E-26
KICH	IUPHAR	MRPS17	PDZD11	0.803149566	1.00E-21
KICH	IUPHAR	MRPS17	PPIA	0.82325514	1.33E-23
LUAD	Cell metabolism gene	MRPS17	SEC61G	0.81899663	1.37E-140
LUAD	Cell metabolism gene	MRPS17	CCT6A	0.868743005	2.62E-177
LUSC	Cell metabolism gene	MRPS17	CCT6A	0.884306443	2.14E-184
PRAD	Cell metabolism gene	MRPS17	SNRPE	0.802513197	5.20E-125
PRAD	Cell metabolism gene	MRPS17	SEC61G	0.829126664	1.66E-140
PRAD	IUPHAR	MRPS17	PPIA	0.837017899	1.27E-145
READ	Cell metabolism gene	MRPS17	POLD2	0.831453252	4.82E-28
TGCT	Cell metabolism gene	MRPS17	UPP1	0.800413328	4.75E-36
TGCT	Cell metabolism gene	MRPS17	TIMM13	0.803698795	1.52E-36
TGCT	Cell metabolism gene	MRPS17	TOMM7	0.805511563	8.00E-37
TGCT	Cell metabolism gene	MRPS17	PSMC5	0.808590598	2.66E-37
TGCT	Cell metabolism gene	MRPS17	SNRPF	0.809166738	2.16E-37
TGCT	Cell metabolism gene	MRPS17	TUBA1C	0.81196094	7.78E-38
TGCT	Cell metabolism gene	MRPS17	SNRPG	0.823978151	7.90E-40
TGCT	Cell metabolism gene	MRPS17	TOMM40	0.854988647	9.22E-46
TGCT	Cell metabolism gene	MRPS17	TIMM50	0.868720464	7.55E-49
TGCT	Epifactor	MRPS17	DNAJC2	0.812162458	7.22E-38
TGCT	IUPHAR	MRPS17	PPIA	0.814962561	2.55E-38
TGCT	TSG	MRPS17	GADD45GIP1	0.800787362	4.17E-36
TGCT	TSG	MRPS17	NOL7	0.840074284	9.46E-43
THYM	Cell metabolism gene	MRPS17	UROS	0.800642739	1.82E-28
THYM	Cell metabolism gene	MRPS17	TPI1	0.801994945	1.26E-28
THYM	Cell metabolism gene	MRPS17	PFDN5	0.802883025	9.92E-29
THYM	Cell metabolism gene	MRPS17	LSM4	0.803642076	8.06E-29
THYM	Cell metabolism gene	MRPS17	PHPT1	0.804500433	6.37E-29
THYM	Cell metabolism gene	MRPS17	PSMC3	0.805052311	5.47E-29
THYM	Cell metabolism gene	MRPS17	TSTA3	0.805288676	5.13E-29
THYM	Cell metabolism gene	MRPS17	PSMB1	0.806463179	3.70E-29
THYM	Cell metabolism gene	MRPS17	HMBS	0.806633063	3.53E-29
THYM	Cell metabolism gene	MRPS17	MIF	0.807438389	2.82E-29
THYM	Cell metabolism gene	MRPS17	PSMD8	0.807775705	2.57E-29
THYM	Cell metabolism gene	MRPS17	OAZ1	0.808150137	2.31E-29
THYM	Cell metabolism gene	MRPS17	POLR2F	0.809067673	1.79E-29
THYM	Cell metabolism gene	MRPS17	SSR2	0.815892509	2.50E-30
THYM	Cell metabolism gene	MRPS17	NME1	0.820199363	6.93E-31
THYM	Cell metabolism gene	MRPS17	NME2	0.822609763	3.33E-31
THYM	Cell metabolism gene	MRPS17	GSTP1	0.823655435	2.41E-31
THYM	Cell metabolism gene	MRPS17	GSTZ1	0.823789135	2.31E-31
THYM	Cell metabolism gene	MRPS17	CYC1	0.824654753	1.77E-31
THYM	Cell metabolism gene	MRPS17	PGP	0.824739892	1.72E-31
THYM	Cell metabolism gene	MRPS17	ALG3	0.82561281	1.31E-31
THYM	Cell metabolism gene	MRPS17	TOMM22	0.826806505	9.03E-32
THYM	Cell metabolism gene	MRPS17	HMOX2	0.828415466	5.43E-32
THYM	Cell metabolism gene	MRPS17	PTGES2	0.828670423	5.01E-32
THYM	Cell metabolism gene	MRPS17	PSMB4	0.831168041	2.24E-32
THYM	Cell metabolism gene	MRPS17	PSMC5	0.832815679	1.31E-32
THYM	Cell metabolism gene	MRPS17	GMPPA	0.834215987	8.28E-33
THYM	Cell metabolism gene	MRPS17	APRT	0.83538902	5.61E-33
THYM	Cell metabolism gene	MRPS17	EXOSC5	0.835529765	5.36E-33
THYM	Cell metabolism gene	MRPS17	ITPA	0.836243747	4.22E-33
THYM	Cell metabolism gene	MRPS17	PMPCA	0.836409359	3.99E-33
THYM	Cell metabolism gene	MRPS17	GUK1	0.836812954	3.49E-33
THYM	Cell metabolism gene	MRPS17	SLC27A5	0.838225889	2.16E-33
THYM	Cell metabolism gene	MRPS17	TOMM40	0.842658637	4.69E-34
THYM	Cell metabolism gene	MRPS17	POLR2J	0.843222947	3.85E-34
THYM	Cell metabolism gene	MRPS17	HSD17B10	0.847865927	7.34E-35
THYM	Cell metabolism gene	MRPS17	PSME2	0.848346287	6.16E-35
THYM	Cell metabolism gene	MRPS17	DPM3	0.848726206	5.36E-35
THYM	Cell metabolism gene	MRPS17	TIMM17B	0.849293486	4.36E-35
THYM	Cell metabolism gene	MRPS17	POLD2	0.849927336	3.45E-35
THYM	Cell metabolism gene	MRPS17	DPM2	0.851516258	1.92E-35
THYM	Cell metabolism gene	MRPS17	GEMIN6	0.853587443	8.80E-36
THYM	Cell metabolism gene	MRPS17	PGLS	0.853880652	7.87E-36
THYM	Cell metabolism gene	MRPS17	SNRPE	0.855517494	4.21E-36
THYM	Cell metabolism gene	MRPS17	WBSCR22	0.858456884	1.35E-36
THYM	Cell metabolism gene	MRPS17	TIMM8B	0.859015544	1.08E-36
THYM	Cell metabolism gene	MRPS17	SEC61G	0.861080494	4.75E-37
THYM	Cell metabolism gene	MRPS17	NANS	0.863112095	2.09E-37
THYM	Cell metabolism gene	MRPS17	TIMM10	0.864099161	1.40E-37
THYM	Cell metabolism gene	MRPS17	PSMC1	0.868311731	2.41E-38
THYM	Cell metabolism gene	MRPS17	ACOT8	0.868392762	2.33E-38
THYM	Cell metabolism gene	MRPS17	MTX1	0.869613254	1.38E-38
THYM	Cell metabolism gene	MRPS17	EBP	0.877720116	3.77E-40
THYM	Cell metabolism gene	MRPS17	POLR2I	0.87964676	1.54E-40
THYM	Cell metabolism gene	MRPS17	GEMIN7	0.881761653	5.68E-41
THYM	Cell metabolism gene	MRPS17	SNRPD2	0.885358047	9.94E-42
THYM	Cell metabolism gene	MRPS17	EXOSC4	0.886367193	6.03E-42
THYM	Cell metabolism gene	MRPS17	PSMB7	0.887186258	4.01E-42
THYM	Cell metabolism gene	MRPS17	PSMD4	0.890837586	6.23E-43
THYM	Cell metabolism gene	MRPS17	ATP5G1	0.891694106	3.99E-43
THYM	Cell metabolism gene	MRPS17	POLR2H	0.892292851	2.91E-43
THYM	Cell metabolism gene	MRPS17	TIMM13	0.892442515	2.69E-43
THYM	Cell metabolism gene	MRPS17	PSMB3	0.894557723	8.72E-44
THYM	Cell metabolism gene	MRPS17	TIMM50	0.903780358	4.76E-46
THYM	CGC	MRPS17	PRCC	0.800021681	2.15E-28
THYM	CGC	MRPS17	TFPT	0.823334717	2.66E-31
THYM	CGC	MRPS17	COX6C	0.847346687	8.86E-35
THYM	Epifactor	MRPS17	PRMT1	0.80229196	1.16E-28
THYM	Epifactor	MRPS17	RRP8	0.816994517	1.81E-30
THYM	Epifactor	MRPS17	TFPT	0.823334717	2.66E-31
THYM	Epifactor	MRPS17	TAF10	0.83294183	1.26E-32
THYM	Epifactor	MRPS17	EXOSC5	0.835529765	5.36E-33
THYM	Epifactor	MRPS17	PRPF31	0.855765355	3.83E-36
THYM	Epifactor	MRPS17	CDK5	0.857261152	2.15E-36
THYM	Epifactor	MRPS17	FBL	0.858758451	1.20E-36
THYM	Epifactor	MRPS17	SIRT6	0.858906234	1.13E-36
THYM	Epifactor	MRPS17	BRMS1	0.872874844	3.34E-39
THYM	Epifactor	MRPS17	ZNHIT1	0.873547129	2.48E-39
THYM	Epifactor	MRPS17	LAS1L	0.881230584	7.31E-41
THYM	Epifactor	MRPS17	EXOSC4	0.886367193	6.03E-42
THYM	IUPHAR	MRPS17	PRMT1	0.80229196	1.16E-28
THYM	IUPHAR	MRPS17	PSMB1	0.806463179	3.70E-29
THYM	IUPHAR	MRPS17	PPIA	0.818546118	1.14E-30
THYM	IUPHAR	MRPS17	HMOX2	0.828415466	5.43E-32
THYM	IUPHAR	MRPS17	PTGES2	0.828670423	5.01E-32
THYM	IUPHAR	MRPS17	FKBP1A	0.829371477	4.00E-32
THYM	IUPHAR	MRPS17	ATP6V0B	0.834758105	6.92E-33
THYM	IUPHAR	MRPS17	SLC27A5	0.838225889	2.16E-33
THYM	IUPHAR	MRPS17	CDK5	0.857261152	2.15E-36
THYM	IUPHAR	MRPS17	SIRT6	0.858906234	1.13E-36
THYM	Kinase	MRPS17	FASTK	0.809091525	1.77E-29
THYM	Kinase	MRPS17	CDK5	0.857261152	2.15E-36
THYM	TF	MRPS17	ZNF524	0.804599409	6.20E-29
THYM	TF	MRPS17	REXO4	0.804894694	5.72E-29
THYM	TF	MRPS17	ZNF32	0.812611497	6.50E-30
THYM	TF	MRPS17	NME2	0.822609763	3.33E-31
THYM	TF	MRPS17	ZNF787	0.823707813	2.37E-31
THYM	TF	MRPS17	USF1	0.828065296	6.07E-32
THYM	TF	MRPS17	ZNF581	0.868362269	2.36E-38
THYM	TSG	MRPS17	RTN4IP1	0.800127338	2.09E-28
THYM	TSG	MRPS17	PHB	0.803697241	7.94E-29
THYM	TSG	MRPS17	GABARAP	0.814141421	4.17E-30
THYM	TSG	MRPS17	NME1	0.820199363	6.93E-31
THYM	TSG	MRPS17	GSTP1	0.823655435	2.41E-31
THYM	TSG	MRPS17	NPRL2	0.823871071	2.26E-31
THYM	TSG	MRPS17	STUB1	0.831379661	2.10E-32
THYM	TSG	MRPS17	TSSC4	0.832351763	1.53E-32
THYM	TSG	MRPS17	SIRT6	0.858906234	1.13E-36
THYM	TSG	MRPS17	BRMS1	0.872874844	3.34E-39
THYM	TSG	MRPS17	GADD45GIP1	0.886972738	4.46E-42
UCEC	Cell metabolism gene	MRPS17	EXOSC4	0.826320254	1.64E-51
UCEC	Cell metabolism gene	MRPS17	POLR2L	0.831417027	1.11E-52
UCEC	Epifactor	MRPS17	BRMS1	0.803775909	9.22E-47
UCEC	Epifactor	MRPS17	EXOSC4	0.826320254	1.64E-51
UCEC	TSG	MRPS17	BRMS1	0.803775909	9.22E-47
UCS	Cell metabolism gene	MRPS17	UROS	0.800642739	1.82E-28
UCS	Cell metabolism gene	MRPS17	TPI1	0.801994945	1.26E-28
UCS	Cell metabolism gene	MRPS17	PFDN5	0.802883025	9.92E-29
UCS	Cell metabolism gene	MRPS17	LSM4	0.803642076	8.06E-29
UCS	Cell metabolism gene	MRPS17	PHPT1	0.804500433	6.37E-29
UCS	Cell metabolism gene	MRPS17	PSMC3	0.805052311	5.47E-29
UCS	Cell metabolism gene	MRPS17	TSTA3	0.805288676	5.13E-29
UCS	Cell metabolism gene	MRPS17	PSMB1	0.806463179	3.70E-29
UCS	Cell metabolism gene	MRPS17	HMBS	0.806633063	3.53E-29
UCS	Cell metabolism gene	MRPS17	MIF	0.807438389	2.82E-29
UCS	Cell metabolism gene	MRPS17	PSMD8	0.807775705	2.57E-29
UCS	Cell metabolism gene	MRPS17	OAZ1	0.808150137	2.31E-29
UCS	Cell metabolism gene	MRPS17	POLR2F	0.809067673	1.79E-29
UCS	Cell metabolism gene	MRPS17	SSR2	0.815892509	2.50E-30
UCS	Cell metabolism gene	MRPS17	NME1	0.820199363	6.93E-31
UCS	Cell metabolism gene	MRPS17	NME2	0.822609763	3.33E-31
UCS	Cell metabolism gene	MRPS17	GSTP1	0.823655435	2.41E-31
UCS	Cell metabolism gene	MRPS17	GSTZ1	0.823789135	2.31E-31
UCS	Cell metabolism gene	MRPS17	CYC1	0.824654753	1.77E-31
UCS	Cell metabolism gene	MRPS17	PGP	0.824739892	1.72E-31
UCS	Cell metabolism gene	MRPS17	ALG3	0.82561281	1.31E-31
UCS	Cell metabolism gene	MRPS17	TOMM22	0.826806505	9.03E-32
UCS	Cell metabolism gene	MRPS17	HMOX2	0.828415466	5.43E-32
UCS	Cell metabolism gene	MRPS17	PTGES2	0.828670423	5.01E-32
UCS	Cell metabolism gene	MRPS17	PSMB4	0.831168041	2.24E-32
UCS	Cell metabolism gene	MRPS17	PSMC5	0.832815679	1.31E-32
UCS	Cell metabolism gene	MRPS17	GMPPA	0.834215987	8.28E-33
UCS	Cell metabolism gene	MRPS17	APRT	0.83538902	5.61E-33
UCS	Cell metabolism gene	MRPS17	EXOSC5	0.835529765	5.36E-33
UCS	Cell metabolism gene	MRPS17	ITPA	0.836243747	4.22E-33
UCS	Cell metabolism gene	MRPS17	PMPCA	0.836409359	3.99E-33
UCS	Cell metabolism gene	MRPS17	GUK1	0.836812954	3.49E-33
UCS	Cell metabolism gene	MRPS17	SLC27A5	0.838225889	2.16E-33
UCS	Cell metabolism gene	MRPS17	TOMM40	0.842658637	4.69E-34
UCS	Cell metabolism gene	MRPS17	POLR2J	0.843222947	3.85E-34
UCS	Cell metabolism gene	MRPS17	HSD17B10	0.847865927	7.34E-35
UCS	Cell metabolism gene	MRPS17	PSME2	0.848346287	6.16E-35
UCS	Cell metabolism gene	MRPS17	DPM3	0.848726206	5.36E-35
UCS	Cell metabolism gene	MRPS17	TIMM17B	0.849293486	4.36E-35
UCS	Cell metabolism gene	MRPS17	POLD2	0.849927336	3.45E-35
UCS	Cell metabolism gene	MRPS17	DPM2	0.851516258	1.92E-35
UCS	Cell metabolism gene	MRPS17	GEMIN6	0.853587443	8.80E-36
UCS	Cell metabolism gene	MRPS17	PGLS	0.853880652	7.87E-36
UCS	Cell metabolism gene	MRPS17	SNRPE	0.855517494	4.21E-36
UCS	Cell metabolism gene	MRPS17	WBSCR22	0.858456884	1.35E-36
UCS	Cell metabolism gene	MRPS17	TIMM8B	0.859015544	1.08E-36
UCS	Cell metabolism gene	MRPS17	SEC61G	0.861080494	4.75E-37
UCS	Cell metabolism gene	MRPS17	NANS	0.863112095	2.09E-37
UCS	Cell metabolism gene	MRPS17	TIMM10	0.864099161	1.40E-37
UCS	Cell metabolism gene	MRPS17	PSMC1	0.868311731	2.41E-38
UCS	Cell metabolism gene	MRPS17	ACOT8	0.868392762	2.33E-38
UCS	Cell metabolism gene	MRPS17	MTX1	0.869613254	1.38E-38
UCS	Cell metabolism gene	MRPS17	EBP	0.877720116	3.77E-40
UCS	Cell metabolism gene	MRPS17	POLR2I	0.87964676	1.54E-40
UCS	Cell metabolism gene	MRPS17	GEMIN7	0.881761653	5.68E-41
UCS	Cell metabolism gene	MRPS17	SNRPD2	0.885358047	9.94E-42
UCS	Cell metabolism gene	MRPS17	EXOSC4	0.886367193	6.03E-42
UCS	Cell metabolism gene	MRPS17	PSMB7	0.887186258	4.01E-42
UCS	Cell metabolism gene	MRPS17	PSMD4	0.890837586	6.23E-43
UCS	Cell metabolism gene	MRPS17	ATP5G1	0.891694106	3.99E-43
UCS	Cell metabolism gene	MRPS17	POLR2H	0.892292851	2.91E-43
UCS	Cell metabolism gene	MRPS17	TIMM13	0.892442515	2.69E-43
UCS	Cell metabolism gene	MRPS17	PSMB3	0.894557723	8.72E-44
UCS	Cell metabolism gene	MRPS17	TIMM50	0.903780358	4.76E-46
UCS	CGC	MRPS17	PRCC	0.800021681	2.15E-28
UCS	CGC	MRPS17	TFPT	0.823334717	2.66E-31
UCS	CGC	MRPS17	COX6C	0.847346687	8.86E-35
UCS	Epifactor	MRPS17	PRMT1	0.80229196	1.16E-28
UCS	Epifactor	MRPS17	RRP8	0.816994517	1.81E-30
UCS	Epifactor	MRPS17	TFPT	0.823334717	2.66E-31
UCS	Epifactor	MRPS17	TAF10	0.83294183	1.26E-32
UCS	Epifactor	MRPS17	EXOSC5	0.835529765	5.36E-33
UCS	Epifactor	MRPS17	PRPF31	0.855765355	3.83E-36
UCS	Epifactor	MRPS17	CDK5	0.857261152	2.15E-36
UCS	Epifactor	MRPS17	FBL	0.858758451	1.20E-36
UCS	Epifactor	MRPS17	SIRT6	0.858906234	1.13E-36
UCS	Epifactor	MRPS17	BRMS1	0.872874844	3.34E-39
UCS	Epifactor	MRPS17	ZNHIT1	0.873547129	2.48E-39
UCS	Epifactor	MRPS17	LAS1L	0.881230584	7.31E-41
UCS	Epifactor	MRPS17	EXOSC4	0.886367193	6.03E-42
UCS	IUPHAR	MRPS17	PRMT1	0.80229196	1.16E-28
UCS	IUPHAR	MRPS17	PSMB1	0.806463179	3.70E-29
UCS	IUPHAR	MRPS17	PPIA	0.818546118	1.14E-30
UCS	IUPHAR	MRPS17	HMOX2	0.828415466	5.43E-32
UCS	IUPHAR	MRPS17	PTGES2	0.828670423	5.01E-32
UCS	IUPHAR	MRPS17	FKBP1A	0.829371477	4.00E-32
UCS	IUPHAR	MRPS17	ATP6V0B	0.834758105	6.92E-33
UCS	IUPHAR	MRPS17	SLC27A5	0.838225889	2.16E-33
UCS	IUPHAR	MRPS17	CDK5	0.857261152	2.15E-36
UCS	IUPHAR	MRPS17	SIRT6	0.858906234	1.13E-36
UCS	Kinase	MRPS17	FASTK	0.809091525	1.77E-29
UCS	Kinase	MRPS17	CDK5	0.857261152	2.15E-36
UCS	TF	MRPS17	ZNF524	0.804599409	6.20E-29
UCS	TF	MRPS17	REXO4	0.804894694	5.72E-29
UCS	TF	MRPS17	ZNF32	0.812611497	6.50E-30
UCS	TF	MRPS17	NME2	0.822609763	3.33E-31
UCS	TF	MRPS17	ZNF787	0.823707813	2.37E-31
UCS	TF	MRPS17	USF1	0.828065296	6.07E-32
UCS	TF	MRPS17	ZNF581	0.868362269	2.36E-38
UCS	TSG	MRPS17	RTN4IP1	0.800127338	2.09E-28
UCS	TSG	MRPS17	PHB	0.803697241	7.94E-29
UCS	TSG	MRPS17	GABARAP	0.814141421	4.17E-30
UCS	TSG	MRPS17	NME1	0.820199363	6.93E-31
UCS	TSG	MRPS17	GSTP1	0.823655435	2.41E-31
UCS	TSG	MRPS17	NPRL2	0.823871071	2.26E-31
UCS	TSG	MRPS17	STUB1	0.831379661	2.10E-32
UCS	TSG	MRPS17	TSSC4	0.832351763	1.53E-32
UCS	TSG	MRPS17	SIRT6	0.858906234	1.13E-36
UCS	TSG	MRPS17	BRMS1	0.872874844	3.34E-39
UCS	TSG	MRPS17	GADD45GIP1	0.886972738	4.46E-42

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPS17	MRPS33	-2.50367423576272	0.000154377851145473
BRCA	MRPS17	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MRPS17	MRPS5	1.25108287838437	0.000249803066253662
LIHC	MRPS17	MRPS7	1.27029395477208	0.00182077236082954
KIRC	MRPS17	MRPS18B	-1.08999348010674	0.00208385211535325
STAD	MRPS17	MRPS16	-1.64208084987431	0.00239070039242506
KIRC	MRPS17	MRPS15	1.11572283836012	0.00361818577801855
HNSC	MRPS17	MRPS16	-2.01564621821803	0.00518989327406416
CHOL	MRPS17	MRPS18B	-1.34341961473083	0.0078125
THCA	MRPS17	MRPS15	-1.19960602422995	0.0140154883942907
BLCA	MRPS17	MRPS18B	-2.79316203705083	0.0180816650390625
ESCA	MRPS17	MRPS5	-2.15440118747854	0.0185546875
LUAD	MRPS17	MRPS18B	-2.59132604284176	0.0228310323601027
STAD	MRPS17	MRPS18B	-2.18783845061495	0.0341199110262096
KICH	MRPS17	MRPS22	1.59345779884986	0.0451226830482483
THCA	MRPS17	MRPS10	1.33413691764991	1.55171507174296e-05
LUAD	MRPS17	MRPS5	-2.20881945885927	1.77904381378076e-06
LUAD	MRPS17	MRPL42	-6.34610249602491	2.48255276366547e-08
LUAD	MRPS17	MRPS14	-3.02634914022647	4.24616078981701e-06
LUSC	MRPS17	MRPS5	-7.65956389962319	4.27210217182982e-06
KIRC	MRPS17	MRPL42	-4.382095336248	5.26630854166927e-06
LUSC	MRPS17	MRPS33	-3.32702669971865	5.71093314566242e-07
LUSC	MRPS17	MRPS14	-3.86726163364221	6.1453992201761e-05
BRCA	MRPS17	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS17

ICT1, RNF2, MED4, ECSIT, THOC1, VPS16, Jup, Samm50, Cep290, ERBB3, ZNF746, KIFAP3, DLST, EFTUD2, ESR2, HEXIM1, MEPCE, LARP7, RECQL4, MB21D1, FBL, HSPD1, AURKAIP1, RC3H1, RC3H2, NR2C2, OASL, SNRNP70, Dppa3, ITFG1, PLEKHA4, ZC3H18, RIPK1, E, nsp3, nsp4, ESR1, GRSF1, ZC3HAV1, CELF1, ARHGAP29, ARHGAP31, Ect2, MYO9A, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, COX15, CRYZ, CS, DHX30, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, CLPP, MAFB, NINL, DNAJC15, DNAJC19, HSCB, MRPS34, MRPS14, TULP3, UFL1, DDRGK1, AARS2, PDHA1, TRAP1, FZR1, MAP4K3, ZBTB2, MRPL30, ZFR, DAP3, MRPS5, MRPS15, WDR33, SUPV3L1, STRBP, MCAT, FAM120A, FREM2, MRPS18C, MRPS31, PREPL, PTCD3, MRPL44, LSM11, MRPS33, MRPS10, ZNF768, MRPS28, POLRMT, GTPBP6, MRPS18B, MRPS21, MRPS22, MRPS23, MRPS9, MRPS24, PTCD1, MRPS6, MRPS2, NOA1, MRPL15, MRPL9, SCYL3, MRPS11, DNAJC21, MRPS27, SIRT1, MRPS25, MRPS7, CPSF4, MRPL28, MRPS35, KBTBD7, TFB1M, DDX55, POLG, MRPS16, TARS2, NISCH, RPL31, YBX3, RBMS2, DDX54, GNL2, MRPS30, ZNF771, FTSJ3, RPL19, MGME1, RCCD1, HNRNPUL2, MRPL2, WBSCR16, TSPYL1, RPL3, PNPT1, ACAD10, KIAA0391, PRKRIR, LARS2, ZNF770, CBWD1, APOBEC3D, HARS2, TMLHE, ZNFX1, ZNF574, ZNF638, YBX1, ERAL1, DHX36, NEIL1, OPTN, EN1, KLF12, YY1, KLF4, SOX15,

Top

Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS17	ESCA	chr7	56022736	56022736	C	T	Silent	p.F86F	5
MRPS17	UCEC	chr7	56020994	56020994	G	T	Missense_Mutation	p.D36Y	2
MRPS17	COAD	chr7	56022804	56022804	C	T	Missense_Mutation	p.P109L	2
MRPS17	KIRC	chr7	56022693	56022693	C	T	Missense_Mutation	p.P72L	2
MRPS17	ESCA	chr7	56022736	56022736	C	T	Silent		2
MRPS17	BLCA	chr7	56022649	56022649	G	A	Silent	p.Q57Q	2
MRPS17	BLCA	chr7	56022758	56022758	C	T	Missense_Mutation	p.P94S	2
MRPS17	BLCA	chr7	56022676	56022676	C	T	Silent	p.L66L	1
MRPS17	HNSC	chr7	56020972	56020972	G	C	Silent		1
MRPS17	COAD	chr7	56020921	56020921	A	G	Silent	p.R11R	1
MRPS17	HNSC	chr7	56020972	56020972	G	C	Silent	p.V28V	1
MRPS17	COAD	chr7	56022603	56022603	A	G	Missense_Mutation	p.Y42C	1
MRPS17	HNSC	chr7	56020908	56020908	C	T	Missense_Mutation	p.S7F	1
MRPS17	BLCA	chr7	56022744	56022744	G	A	Missense_Mutation		1
MRPS17	ESCA	chr7	56022736	56022736	C	T	Silent	p.F86	1
MRPS17	LIHC	chr7	56022810	56022810	G	C	Missense_Mutation		1
MRPS17	BLCA	chr7	56022649	56022649	G	A	Silent		1
MRPS17	ESCA	chr7	56022767	56022767	G	T	Nonsense_Mutation	p.G97*	1
MRPS17	LUAD	chr7	55980359	55980359	G	T	Splice_Site		1
MRPS17	BLCA	chr7	56022758	56022758	C	T	Missense_Mutation		1
MRPS17	LUAD	chr7	56020943	56020943	G	T	Missense_Mutation	p.G19W	1
MRPS17	BLCA	chr7	56022676	56022676	C	T	Silent		1
MRPS17	LUSC	chr7	56020981	56020981	C	A	Silent	p.T31T	1
MRPS17	BLCA	chr7	56022744	56022744	G	A	Missense_Mutation	p.G89E	1
MRPS17	ESCA	chr7	56022767	56022767	G	T	Nonsense_Mutation	p.G97X	1
MRPS17	SKCM	chr7	56020909	56020909	C	A	Silent	p.S7S	1
MRPS17	GBM	chr7	56020892	56020892	T	C	Missense_Mutation		1
MRPS17	SKCM	chr7	56022730	56022730	C	T	Silent	p.I84I	1
MRPS17	HNSC	chr7	56020908	56020908	C	T	Missense_Mutation		1

Copy number variation (CNV) of MRPS17
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS17
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
32426	N/A	BF816390	GAPDH	chr12	6643686	-	MRPS17	chr7	56022696	+
55136	HNSC	TCGA-CV-7236	MRPS17	chr7	55955373	+	FKBP9L	chr7	55780943	-
102799	BLCA	TCGA-XF-A9SK	MRPS17	chr7	55980416	+	NELFB	chr9	140166533	+
92946	GBM	TCGA-06-0743	MRPS17	chr7	56021011	+	PSPH	chr7	56079562	-
92946	LUSC	TCGA-21-A5DI-01A	MRPS17	chr7	56019623	+	PSPH	chr7	56082864	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	MRPS17	0.00697588203411962	0.2

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	MRPS17	0.0113360093484193	0.35
THCA	MRPS17	0.0383298484593321	1
KIRC	MRPS17	0.00220905597416286	0.071
LGG	MRPS17	1.24304974536698e-06	4.1e-05
SARC	MRPS17	0.0471601188303762	1
CHOL	MRPS17	0.0163726354990235	0.49

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source