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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: YTHDF2 (NCBI Gene ID:51441)


Gene Summary

check button Gene Summary
Gene InformationGene Name: YTHDF2
Gene ID: 51441
Gene Symbol

YTHDF2

Gene ID

51441

Gene NameYTH N6-methyladenosine RNA binding protein 2
SynonymsCAHL|HGRG8|NY-REN-2
Cytomap

1p35.3

Type of Geneprotein-coding
DescriptionYTH domain-containing family protein 29430020E02RikCLL-associated antigen KW-14YTH N(6)-methyladenosine RNA binding protein 2YTH domain family, member 2high-glucose-regulated protein 8renal carcinoma antigen NY-REN-2
Modification date20200313
UniProtAcc

Q9Y5A9


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0017148Negative regulation of translation
GO:0006417Regulation of translation
GO:0045727Positive regulation of translation
GO:0002181Cytoplasmic translation
GO:0006413Translational initiation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYTHDF2

GO:0006402

mRNA catabolic process

27558897|30559377|30930054

HgeneYTHDF2

GO:0061157

mRNA destabilization

27558897|30559377|30930054

HgeneYTHDF2

GO:1903679

positive regulation of cap-independent translational initiation

26458103



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
YTHDF2(733 - 1119.25]


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Translation Studies in PubMed

check button We searched PubMed using 'YTHDF2[title] AND translation [title] AND human.'
GeneTitlePMID
YTHDF2PBRM1 Cooperates with YTHDF2 to Control HIF-1α Protein Translation34200988


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST0000054250729063558290636595CDS-5UTR
ENST000003738122906416929064194Frame-shift
ENST000005425072906416929064194Frame-shift
ENST000003738122906891429070498In-frame
ENST000005425072906891429070498In-frame

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST0000054250729068914290704982842396197957944572
ENST0000037381229068914290704982942495207857944572

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
Q9Y5A9445722579ChainID=PRO_0000223075;Note=YTH domain-containing family protein 2
Q9Y5A9445722579ChainID=PRO_0000223075;Note=YTH domain-containing family protein 2
Q9Y5A944572410544DomainNote=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
Q9Y5A944572410544DomainNote=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
Q9Y5A9445722384RegionNote=Localization to mRNA processing bodies (P-bodies);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
Q9Y5A9445722384RegionNote=Localization to mRNA processing bodies (P-bodies);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
Q9Y5A944572385579RegionNote=Interaction with m6A-containing mRNAs;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
Q9Y5A944572385579RegionNote=Interaction with m6A-containing mRNAs;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
Q9Y5A944572416418RegionNote=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572416418RegionNote=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572432433RegionNote=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572432433RegionNote=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572422422Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572422422Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572462462Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572462462Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572486486Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572486486Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572491491Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572491491Binding siteNote=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572196196Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y5A944572196196Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y5A944572359359Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9Y5A944572359359Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9Y5A944572394394Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
Q9Y5A944572394394Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
Q9Y5A944572150Alternative sequenceID=VSP_009297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
Q9Y5A944572150Alternative sequenceID=VSP_009297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
Q9Y5A944572217217Natural variantID=VAR_053744;Note=T->S;Dbxref=dbSNP:rs16838382
Q9Y5A944572217217Natural variantID=VAR_053744;Note=T->S;Dbxref=dbSNP:rs16838382
Q9Y5A944572454454Natural variantID=VAR_053745;Note=P->S;Dbxref=dbSNP:rs35288745
Q9Y5A944572454454Natural variantID=VAR_053745;Note=P->S;Dbxref=dbSNP:rs35288745
Q9Y5A944572411411MutagenesisNote=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
Q9Y5A944572411411MutagenesisNote=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
Q9Y5A944572416416MutagenesisNote=Decreased binding to RNAs. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
Q9Y5A944572416416MutagenesisNote=Decreased binding to RNAs. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
Q9Y5A944572432432MutagenesisNote=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
Q9Y5A944572432432MutagenesisNote=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
Q9Y5A944572441441MutagenesisNote=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
Q9Y5A944572441441MutagenesisNote=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
Q9Y5A944572486486MutagenesisNote=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
Q9Y5A944572486486MutagenesisNote=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
Q9Y5A944572491491MutagenesisNote=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572491491MutagenesisNote=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
Q9Y5A944572527527MutagenesisNote=Decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
Q9Y5A944572527527MutagenesisNote=Decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
Q9Y5A944572411418Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572411418Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572420429HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572420429HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572430432Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WQN
Q9Y5A944572430432Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WQN
Q9Y5A944572436449HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572436449HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572455461Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572455461Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572464473Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572464473Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572478481Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDO
Q9Y5A944572478481Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDO
Q9Y5A944572486488Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572486488Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572494506Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572494506Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572507509HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572507509HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572510512TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572510512TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572516520TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572516520TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572523525HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572523525HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572534546HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
Q9Y5A944572534546HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
LUADYTHDF21.212677263157510.00092062023200824
STADYTHDF2-4.956941207415370.00361521635204554


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
ESCAYTHDF2120.01362002312871580.1849753676470590.2634031625553450.6023290655485240.102921807483745

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
OVYTHDF2210.02598979236766010.2694334708612690.1942571428571430.8349531630215810.351575033290348
UCECYTHDF2210.02472240004247150.2252374535050070.1762466666666670.2341115762779041.66394573221552

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with YTHDF2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
LGGCell metabolism geneYTHDF2PSMB20.8638697682.28E-159
LGGCell metabolism geneYTHDF2DDX200.8650274122.81E-160
LGGIUPHARYTHDF2PSMB20.8638697682.28E-159
TGCTCell metabolism geneYTHDF2CCT80.8186666976.26E-39
TGCTCell metabolism geneYTHDF2CCT6A0.8396151531.16E-42
TGCTIUPHARYTHDF2SLC45A40.819797914.05E-39
TGCTTFYTHDF2ZNF5780.804738031.05E-36
TGCTTFYTHDF2MYBL20.8049281619.83E-37
UVMCell metabolism geneYTHDF2CMPK10.811461287.02E-20
UVMCell metabolism geneYTHDF2ACADM0.8305767951.60E-21
UVMCell metabolism geneYTHDF2FPGT0.8344531217.01E-22
UVMCell metabolism geneYTHDF2PIGK0.8425559191.16E-22
UVMCell metabolism geneYTHDF2PPCS0.855409365.43E-24
UVMCGCYTHDF2NRAS0.8143658464.06E-20
UVMCGCYTHDF2BCL100.8218091959.58E-21
UVMCGCYTHDF2STIL0.8247526855.31E-21
UVMCGCYTHDF2SFPQ0.8461955515.03E-23
UVMEpifactorYTHDF2MTF20.8048029172.37E-19
UVMEpifactorYTHDF2SFPQ0.8461955515.03E-23
UVMEpifactorYTHDF2RBBP40.8494156722.35E-23
UVMEpifactorYTHDF2HP1BP30.858363942.58E-24
UVMIUPHARYTHDF2NRAS0.8143658464.06E-20
UVMIUPHARYTHDF2SLC35D10.8145795973.90E-20
UVMIUPHARYTHDF2PKN20.8228139687.84E-21
UVMIUPHARYTHDF2USP10.8272013813.22E-21
UVMIUPHARYTHDF2PDIK1L0.8371143713.93E-22
UVMKinaseYTHDF2PKN20.8228139687.84E-21
UVMKinaseYTHDF2PDIK1L0.8371143713.93E-22
UVMTFYTHDF2MTF20.8048029172.37E-19
UVMTFYTHDF2GTF2B0.8094148211.03E-19
UVMTFYTHDF2ZNF3260.8159505833.00E-20
UVMTFYTHDF2MTF10.8264917343.73E-21
UVMTFYTHDF2GPBP1L10.8541849957.37E-24
UVMTFYTHDF2RLF0.8546918666.50E-24
UVMTSGYTHDF2TRIT10.804785922.38E-19
UVMTSGYTHDF2BCL100.8218091959.58E-21
UVMTSGYTHDF2SH3GLB10.8290823432.18E-21


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
COADYTHDF2ALKBH52.137555521474880.000465095043182374
KIRCYTHDF2RBM15-1.350077132011060.000600141235926365
COADYTHDF2KIAA1429-3.394209816460750.000664144754409791
LUADYTHDF2METTL14-1.435965945965230.00121089428940613
PRADYTHDF2RBM15-1.093278079177140.00277499505363991
HNSCYTHDF2ALKBH1-2.395388421096830.00633394569399571
LUADYTHDF2WTAP-1.786162260908530.00791615044666943
LUADYTHDF2RBM15-1.245797937291440.0103856608841715
KIRCYTHDF2WTAP-2.702736604950670.0143053039058135
BLCAYTHDF2WTAP-2.908819548467390.0159721374511719
STADYTHDF2KIAA1429-1.615671032805560.020511694252491
READYTHDF2ALKBH52.444043667148170.03125
CHOLYTHDF2KIAA1429-2.832292004427680.0390625
CHOLYTHDF2METTL3-3.319434956918480.0390625
UCECYTHDF2WTAP-3.786291472213770.046875
THCAYTHDF2ALKBH5-1.263707420713881.35265985423686e-05
COADYTHDF2METTL3-3.542889187408572.08616256713867e-06
THCAYTHDF2KIAA14291.46880078297042.5764473552472e-05
THCAYTHDF2METTL14-2.30919316658243.03433720687169e-07
BRCAYTHDF2FTO-2.094940106965943.14552302519821e-23
LIHCYTHDF2METTL3-1.433814476677083.17814170396599e-08
KIRCYTHDF2FTO1.082341243849344.81926317698848e-12
PRADYTHDF2METTL32.277776677435575.10126106041513e-07
HNSCYTHDF2RBM151.406151825693035.61373060463667e-05
THCAYTHDF2WTAP-2.893924438670045.83719995580266e-05
KIRCYTHDF2ALKBH51.220084432699928.228320553924e-07


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with YTHDF2
HNRNPA1, HNRNPH1, MEPCE, POT1, ELAVL1, CUL3, CAND1, SMAD3, APP, ESR1, EPAS1, FN1, VCAM1, HIPK4, FBXO6, TARDBP, EIF3A, EIF3H, RPA3, RPA2, RPA1, RNF2, BMI1, RPS6KB2, AGL, HMBS, ASPSCR1, SEPT7, SFPQ, USP13, USP5, NTRK1, B9D2, DCTN1, CEP19, XPO1, RPL10, Hnrnpf, MCM2, Ksr1, OTUB1, G3BP1, CFTR, UBE3A, WWOX, MYC, FBL, GRWD1, RC3H1, RC3H2, PHB, TGFBR2, FAF1, ZC3H7A, TMEM41B, USP14, NIN, ATXN3, VRK3, SLC25A28, SLC15A3, SNRNP70, CYLD, PPP1CA, NFX1, BRD7, TRIM28, CBFB, PLEKHA4, MAGEA3, KCTD10, PTEN, HCVgp1, MAP3K14, PTK6, AGO2, ALG13, ANKRD17, ATXN2, CAPRIN1, CELF1, CEP85, CNOT2, CNOT6L, CNOT7, RQCD1, CPEB4, CSDE1, CTIF, DAZL, DCP1A, DDX3X, EIF4ENIF1, FAM120C, FMR1, FUBP3, FXR1, FXR2, HELZ, IGF2BP1, IGF2BP2, KIF1B, LARP4B, LSM14A, KIAA0430, MEX3B, MKRN2, MOV10, OTUD4, PABPC1, PATL1, PRRC2A, PRRC2B, PUM1, R3HDM2, RBM47, RBMS1, RNF214, SAMD4B, SMAP2, SMG6, SMG7, SYNCRIP, TDRD3, TNRC6B, UBAP2L, UNK, XRN1, YTHDF1, CNOT1, PRRC2C, R3HDM1, TOP3B, UPF1, AGO1, AGO3, ATXN2L, CNOT10, CNOT11, CNOT3, CNOT4, CNOT8, DCP1B, DDX6, EIF4E, EIF4E2, EIF4G2, EIF4G3, FAM98A, G3BP2, GIGYF1, KIAA0355, LARP4, LSM12, LSM14B, FAM195B, FAM195A, MEX3A, NUFIP2, PABPC4, PAN2, PAN3, PUM2, RBMS2, RTCB, SECISBP2, SMG1, SMG5, SMG8, TMEM57, TNRC6A, TNRC6C, UBAP2, USP10, YBX3, YTHDF3, ZCCHC11, ZCCHC2, ZNF598, ZC3HAV1, ZFP36, EIF4A2, PAIP2, STAU1, C14orf166, TNKS1BP1, FAM120A, ANKHD1-EIF4EBP3, BMP2K, CASC3, CNOT6, DZIP3, GLE1, GTPBP1, PFDN1, TRIM56, KIF14, MKI67, FASN, LDLR, MAFB, C18orf8, CIC, COPS5, RBM39, CREBBP, SKP2, RIN3, OGT, PARK2, DDRGK1, TP53, ACBD5, AKAP1, HSD3B7, RPS20, SERBP1, ZYX, FZR1, NAA40, FBXW7, BMF, TMPRSS2, CTSL, FURIN, BSG, IFITM3, CLEC4D, TMPRSS4, CLEC4E, E, ORF10, ORF3a, ORF8, NRP1, IFITM1, NBR1, CPEB1, GLI3, KLF15, RB1CC1, KLF16, KLF8, MAGEL2,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
YTHDF2LUADchr12907032429070324CGSilentp.R514R4
YTHDF2UCECchr12906911929069119ATMissense_Mutationp.S113C3
YTHDF2ESCAchr12907026829070268GAMissense_Mutationp.D496N3
YTHDF2PRADchr12906996029069960GAMissense_Mutationp.R393Q3
YTHDF2STADchr12907047029070470GAMissense_Mutationp.R563H2
YTHDF2ESCAchr12907026829070268GAMissense_Mutation2
YTHDF2UCECchr12907021729070217TCMissense_Mutationp.Y479H2
YTHDF2LIHCchr12906896629068966C-Frame_Shift_Delp.P62fs2
YTHDF2SKCMchr12907005929070059CTMissense_Mutationp.S426F2
YTHDF2HNSCchr12909545029095450GAMissense_Mutationp.G576S2
YTHDF2LUADchr12906906229069062ATMissense_Mutationp.N94Y2
YTHDF2STADchr12907032229070322CTMissense_Mutationp.R514C2
YTHDF2HNSCchr12906984529069845CTMissense_Mutationp.R355W2
YTHDF2LUADchr12906990329069903CTMissense_Mutationp.S374F2
YTHDF2STADchr12906958129069581C-Frame_Shift_Delp.P266fs2
YTHDF2COADchr12907019029070190GAMissense_Mutationp.V420M2
YTHDF2KIRCchr12906917029069170GAMissense_Mutationp.D130N2
YTHDF2STADchr12906989829069898ACSilentp.G372G2
YTHDF2BLCAchr12907032829070328GCMissense_Mutation2
YTHDF2LUADchr12906939229069392CGMissense_Mutationp.P204A2
YTHDF2BLCAchr12907032829070328GCMissense_Mutationp.E516Q2
YTHDF2CESCchr12906480929064809GAMissense_Mutation2
YTHDF2KIRCchr12906923529069235CGMissense_Mutationp.S151R2
YTHDF2SKCMchr12906482929064829CTSilentp.Y37Y2
YTHDF2LIHCchr12906911129069111C-Frame_Shift_Delp.A110fs2
YTHDF2STADchr12907018929070189CTSilentp.G469G2
YTHDF2BLCAchr12909544029095440GASplice_Site2
YTHDF2LUADchr12906938129069381CTMissense_Mutationp.A200V2
YTHDF2SKCMchr12906481929064819TAMissense_Mutationp.F34Y2
YTHDF2LIHCchr12906952329069523A-Frame_Shift_Delp.A247fs2
YTHDF2STADchr12906907729069077TGMissense_Mutationp.F99V2
YTHDF2BLCAchr12906993029069930CTMissense_Mutationp.S383L2
YTHDF2LIHCchr12906972729069727AGSilent2
YTHDF2LIHCchr12906958129069581C-Frame_Shift_Delp.P268fs2
YTHDF2STADchr12907012829070128TCMissense_Mutationp.M449T2
YTHDF2STADchr12907021829070218AGMissense_Mutationp.Y479C2
YTHDF2UCECchr12906916729069167AGMissense_Mutationp.I129V2
YTHDF2BLCAchr12907032829070328GAMissense_Mutationp.E516K2
YTHDF2LIHCchr12906901329069013G-Frame_Shift_Delp.T77fs2
YTHDF2STADchr12906901229069012CTMissense_Mutationp.T77M2
YTHDF2UCECchr12906997229069972ATMissense_Mutationp.N397I2
YTHDF2COADchr12906968329069683CTNonsense_Mutationp.Q251X1
YTHDF2LIHCchr12906972729069727AGSilentp.P315P1
YTHDF2SKCMchr12906940829069408CTMissense_Mutationp.S209F1
YTHDF2LIHCchr12906915529069155T-Frame_Shift_Delp.F125fs1
YTHDF2BLCAchr12907031429070314GTMissense_Mutation1
YTHDF2READchr12909544429095444CTMissense_Mutationp.R524C1
YTHDF2BLCAchr12907008829070088GCMissense_Mutationp.E436Q1
YTHDF2HNSCchr12906984529069845CTMissense_Mutation1
YTHDF2COADchr12907005629070056GAMissense_Mutationp.R375H1
YTHDF2STADchr12906927729069279TGA-In_Frame_Delp.165_166del1
YTHDF2BLCAchr12906944229069442CTSilent1
YTHDF2ESCAchr12907045529070456CA-Frame_Shift_Del1
YTHDF2SARCchr12906357229063574GCC-RNANULL1
YTHDF2BLCAchr12906998629069986GTMissense_Mutationp.D402Y1
YTHDF2COADchr12907005929070059CTMissense_Mutationp.S376F1
YTHDF2SKCMchr12906992729069927CTMissense_Mutationp.P382L1
YTHDF2BLCAchr12906998629069986GTMissense_Mutation1
YTHDF2ESCAchr12906910829069108GAMissense_Mutation1
YTHDF2BLCAchr12906944229069442CTSilentp.I220I1
YTHDF2SKCMchr12906926129069261TANonsense_Mutationp.L110X1
YTHDF2STADchr12906482529064828CTTA-Frame_Shift_Delp.36_37del1
YTHDF2COADchr12907015529070155T-Frame_Shift_Delp.L458fs1
YTHDF2STADchr12906927729069279TGA-In_Frame_Delp.D166del1
YTHDF2BLCAchr12906904529069045CTMissense_Mutation1
YTHDF2ESCAchr12907045529070456CA-Frame_Shift_Delp.558_558del1
YTHDF2BLCAchr12906904529069045CTMissense_Mutationp.S88F1
YTHDF2HNSCchr12906949929069499GANonsense_Mutationp.W239*1
YTHDF2SKCMchr12906928229069282GAMissense_Mutationp.G117E1
YTHDF2BLCAchr12906898329068983CTSilent1
YTHDF2LUADchr12906936929069369GTMissense_Mutationp.S196I1
YTHDF2STADchr12906482529064828CTTA-Frame_Shift_Delp.P36fs1
YTHDF2BLCAchr12906898329068983CTSilentp.S67S1
YTHDF2ESCAchr12907045529070456CA-Frame_Shift_Delp.S558fs1
YTHDF2BLCAchr12909544029095440GASplice_Sitep.E573_splice1
YTHDF2SKCMchr12906940829069408CTMissense_Mutationp.S159F1
YTHDF2COADchr12907032329070323GAMissense_Mutationp.R464H1
YTHDF2THYMchr12906963229069632GTMissense_Mutationp.V284F1
YTHDF2GBMchr12906901329069013GASilentp.T77T1
YTHDF2COADchr12907033729070337GAMissense_Mutationp.E469K1
YTHDF2UCECchr12906963229069632GAMissense_Mutationp.V284I1
YTHDF2BLCAchr12906920029069200CTNonsense_Mutationp.Q140*1
YTHDF2GBMchr12906955029069550GASilent1
YTHDF2CESCchr12906480929064809GAMissense_Mutationp.D31N1
YTHDF2KIRPchr12906910729069107GTNonsense_Mutation1
YTHDF2BLCAchr12906993029069930CTMissense_Mutation1
YTHDF2DLBCchr12907028429070284TCMissense_Mutationp.F501S1
YTHDF2LUSCchr12907023729070237GTSilentp.V485V1
YTHDF2UCECchr12906976329069763GTMissense_Mutationp.Q327H1
YTHDF2GBMchr12907029529070295GAMissense_Mutation1
YTHDF2COADchr12906918229069183-GFrame_Shift_Insp.W134fs1
YTHDF2SKCMchr12907013529070135GASilentp.G451G1
YTHDF2BLCAchr12907012929070129GAMissense_Mutation1
YTHDF2ESCAchr12906910829069108GAMissense_Mutationp.G109E1
YTHDF2LUSCchr12909544529095445GCMissense_Mutationp.R574P1
YTHDF2BLCAchr12907012929070129GAMissense_Mutationp.M449I1
YTHDF2GBMchr12906901329069013GASilent1
YTHDF2COADchr12906951929069519CAMissense_Mutationp.P196H1
YTHDF2LIHCchr12906896929068969TCMissense_Mutation1
YTHDF2SKCMchr12906928229069282GAMissense_Mutationp.G167E1
YTHDF2LIHCchr12906481729064817T-Frame_Shift_Delp.D33fs1
YTHDF2BLCAchr12906966429069664GCMissense_Mutation1
YTHDF2HNSCchr12909545029095450GAMissense_Mutation1
YTHDF2COADchr12906963229069632GAMissense_Mutationp.V234I1
YTHDF2LIHCchr12907016529070165CTSilentp.V461V1
YTHDF2SKCMchr12906926129069261TANonsense_Mutationp.L160*1
YTHDF2BLCAchr12907008829070088GCMissense_Mutation1
YTHDF2ESCAchr12907045529070456CA-Frame_Shift_Delp.H559fs1
YTHDF2READchr12906951729069517GASilentp.K195K1
YTHDF2BLCAchr12906966429069664GCMissense_Mutationp.Q294H1
YTHDF2HNSCchr12907001429070014GTMissense_Mutation1

check buttonCopy number variation (CNV) of YTHDF2
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across YTHDF2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
101328BRCATCGA-E2-A14TARID1Achr127059283+YTHDF2chr129064169+
101328BRCATCGA-E2-A14T-01AARID1Achr127059282+YTHDF2chr129063558+
101328BRCATCGA-E2-A14T-01AARID1Achr127059282+YTHDF2chr129064169+
101328BRCATCGA-E2-A14T-01AARID1Achr127059283+YTHDF2chr129064170+
101328N/AEC575148CAPN12chr1939255541-YTHDF2chr129069339-
101328LIHCTCGA-BC-A3KG-01AEPB41chr129365938+YTHDF2chr129095441+
101328PCPGTCGA-QR-A70V-01AEPB41chr129213722+YTHDF2chr129068940+
101328PCPGTCGA-QR-A70V-01AEPB41chr129220349-YTHDF2chr129068915+
101328UCSTCGA-N8-A4PI-01AEPB41chr129320054-YTHDF2chr129068915+
101328BRCATCGA-EW-A1PB-01AETV6chr1211992237+YTHDF2chr129095440+
101328BRCATCGA-EW-A1PB-01AETV6chr1211992238+YTHDF2chr129095441+
101328STADTCGA-KB-A93HGMEB1chr129010252+YTHDF2chr129064169+
101328BRCATCGA-A2-A04T-01AKIAA0319Lchr135936464-YTHDF2chr129095441+
101328BRCATCGA-AC-A6IW-01APHACTR4chr128733974+YTHDF2chr129095441+
101328acute myeloid leukemiaEU093085RUNX1chr2136231803YTHDF2chr129095441
101328N/AEU093085RUNX1chr2136231770-YTHDF2chr129095441+
101328HNSCTCGA-CQ-6228YIPF1chr154343987-YTHDF2chr129095440+
101328HNSCTCGA-CQ-6228YIPF1chr154344314-YTHDF2chr129095440+
101328HNSCTCGA-CQ-6228YIPF1chr154344315-YTHDF2chr129095441+
101328HNSCTCGA-CQ-6228-01AYIPF1chr154343988-YTHDF2chr129095441+
102097PRADTCGA-CH-5745-01AYTHDF2chr129070498+ARSBchr578077797-
100105UCSTCGA-N6-A4VG-01AYTHDF2chr129070498+EYA3chr128304985-
100105LUSCTCGA-NC-A5HJ-01AYTHDF2chr129070498+RAB42chr128920206+
101328BRCATCGA-A2-A4RW-01AZMPSTE24chr140737707+YTHDF2chr129095441+


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
KIRCYTHDF20.002388372350893030.064
HNSCYTHDF20.009731219437603150.25
BRCAYTHDF20.01575049695012910.39
LUSCYTHDF20.02873473817971050.69
PAADYTHDF20.04663754829108961
TGCTYTHDF28.49614656788005e-050.0024

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LGGYTHDF20.02071578219254340.64
BRCAYTHDF21.80466308890852e-066e-05
UCECYTHDF20.02863817442002190.86
ACCYTHDF20.003627048382685450.12

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C2239176Liver carcinoma1CTD_human