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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL16 (NCBI Gene ID:54948)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL16
	Gene ID: 54948
	Gene Symbol	MRPL16
	Gene ID	54948
	Gene Name	mitochondrial ribosomal protein L16
	Synonyms	L16mt\|MRP-L16\|PNAS-111
	Cytomap	11q12.1
	Type of Gene	protein-coding
	Description	39S ribosomal protein L16, mitochondrialmitochondrial large ribosomal subunit protein uL16m
	Modification date	20200313
	UniProtAcc	Q9NX20

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL16	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL16[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL16	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
LUAD	MRPL16	hsa-miR-582-5p	98	0.311294452347084	0.00676233683273421

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUAD	MRPL16	0.145348876	0.034221168

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL16 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	MRPL16	MMAB	0.80106405	3.89E-11
CHOL	Cell metabolism gene	MRPL16	PCCB	0.806688646	2.23E-11
CHOL	Cell metabolism gene	MRPL16	UCK1	0.80772405	2.01E-11
CHOL	Cell metabolism gene	MRPL16	HSD17B10	0.808192631	1.92E-11
CHOL	Cell metabolism gene	MRPL16	ACACB	0.816214479	8.34E-12
CHOL	Cell metabolism gene	MRPL16	ACADS	0.817379857	7.36E-12
CHOL	Cell metabolism gene	MRPL16	IVD	0.817492174	7.27E-12
CHOL	Cell metabolism gene	MRPL16	DHRS4	0.81802782	6.87E-12
CHOL	Cell metabolism gene	MRPL16	GCDH	0.818418229	6.58E-12
CHOL	Cell metabolism gene	MRPL16	GRPEL1	0.82013447	5.47E-12
CHOL	Cell metabolism gene	MRPL16	FXN	0.82075815	5.11E-12
CHOL	Cell metabolism gene	MRPL16	SDHB	0.831082846	1.59E-12
CHOL	Cell metabolism gene	MRPL16	ECHS1	0.83708562	7.79E-13
CHOL	Cell metabolism gene	MRPL16	QDPR	0.838748208	6.36E-13
CHOL	Cell metabolism gene	MRPL16	DHRS4L2	0.842041022	4.23E-13
CHOL	Cell metabolism gene	MRPL16	CRAT	0.84220573	4.14E-13
CHOL	Cell metabolism gene	MRPL16	EBP	0.850978059	1.33E-13
CHOL	Cell metabolism gene	MRPL16	PMPCA	0.882493096	1.12E-15
CHOL	CGC	MRPL16	SDHB	0.831082846	1.59E-12
CHOL	IUPHAR	MRPL16	PCCB	0.806688646	2.23E-11
CHOL	IUPHAR	MRPL16	NUDT7	0.809192731	1.73E-11
CHOL	IUPHAR	MRPL16	ACACB	0.816214479	8.34E-12
CHOL	IUPHAR	MRPL16	SLC2A8	0.822069604	4.42E-12
CHOL	TSG	MRPL16	FXN	0.82075815	5.11E-12
CHOL	TSG	MRPL16	SDHB	0.831082846	1.59E-12
GBM	Epifactor	MRPL16	DPY30	0.800916026	1.04E-39
THYM	Cell metabolism gene	MRPL16	ANP32A	0.801061795	1.62E-28
THYM	Cell metabolism gene	MRPL16	GNA15	0.802607149	1.07E-28
THYM	Cell metabolism gene	MRPL16	PFDN1	0.806722728	3.44E-29
THYM	Cell metabolism gene	MRPL16	PDE6D	0.810163757	1.31E-29
THYM	Cell metabolism gene	MRPL16	IDH2	0.810569452	1.17E-29
THYM	Cell metabolism gene	MRPL16	EXOSC1	0.813260407	5.39E-30
THYM	Cell metabolism gene	MRPL16	ADA	0.814560094	3.69E-30
THYM	Cell metabolism gene	MRPL16	PSMA6	0.824989339	1.60E-31
THYM	Cell metabolism gene	MRPL16	ZNRD1	0.826855631	8.89E-32
THYM	Cell metabolism gene	MRPL16	LSM5	0.827696319	6.82E-32
THYM	Cell metabolism gene	MRPL16	NT5M	0.834077961	8.67E-33
THYM	Cell metabolism gene	MRPL16	TUBA1B	0.838048882	2.30E-33
THYM	Cell metabolism gene	MRPL16	SEC61B	0.840010295	1.18E-33
THYM	Cell metabolism gene	MRPL16	SRP14	0.846381668	1.25E-34
THYM	Cell metabolism gene	MRPL16	SNRPF	0.858603437	1.27E-36
THYM	Cell metabolism gene	MRPL16	DUT	0.859597877	8.58E-37
THYM	Cell metabolism gene	MRPL16	GNG5	0.869000105	1.80E-38
THYM	Cell metabolism gene	MRPL16	SNRPG	0.898615403	9.37E-45
THYM	CGC	MRPL16	EWSR1	0.80372254	7.89E-29
THYM	CGC	MRPL16	CCND3	0.809270148	1.69E-29
THYM	CGC	MRPL16	IDH2	0.810569452	1.17E-29
THYM	CGC	MRPL16	U2AF1	0.846218969	1.33E-34
THYM	CGC	MRPL16	H3F3A	0.900234735	3.75E-45
THYM	Epifactor	MRPL16	HMGB1	0.80013192	2.09E-28
THYM	Epifactor	MRPL16	ANP32A	0.801061795	1.62E-28
THYM	Epifactor	MRPL16	CBX3	0.802684716	1.05E-28
THYM	Epifactor	MRPL16	H2AFY	0.804892365	5.72E-29
THYM	Epifactor	MRPL16	UBE2T	0.806975038	3.21E-29
THYM	Epifactor	MRPL16	PRR14	0.810346361	1.24E-29
THYM	Epifactor	MRPL16	HIST1H2BH	0.810669081	1.13E-29
THYM	Epifactor	MRPL16	EXOSC1	0.813260407	5.39E-30
THYM	Epifactor	MRPL16	MAZ	0.814288287	4.00E-30
THYM	Epifactor	MRPL16	HIST1H3F	0.815531368	2.78E-30
THYM	Epifactor	MRPL16	HIST2H2AC	0.817000196	1.80E-30
THYM	Epifactor	MRPL16	NASP	0.817111605	1.74E-30
THYM	Epifactor	MRPL16	ANP32B	0.828838829	4.74E-32
THYM	Epifactor	MRPL16	AURKB	0.830936331	2.42E-32
THYM	Epifactor	MRPL16	HMGN2	0.841008705	8.34E-34
THYM	Epifactor	MRPL16	PADI4	0.844416706	2.53E-34
THYM	Epifactor	MRPL16	H1FX	0.847324395	8.93E-35
THYM	Epifactor	MRPL16	PCNA	0.851804327	1.72E-35
THYM	Epifactor	MRPL16	VRK1	0.854936089	5.27E-36
THYM	Epifactor	MRPL16	H2AFX	0.85527069	4.63E-36
THYM	Epifactor	MRPL16	H2AFZ	0.859264229	9.79E-37
THYM	Epifactor	MRPL16	HIRIP3	0.874201368	1.85E-39
THYM	Epifactor	MRPL16	RBX1	0.885137856	1.11E-41
THYM	Epifactor	MRPL16	H3F3A	0.900234735	3.75E-45
THYM	IUPHAR	MRPL16	PVRIG	0.800998503	1.65E-28
THYM	IUPHAR	MRPL16	CD247	0.801028145	1.64E-28
THYM	IUPHAR	MRPL16	CD3E	0.803975033	7.36E-29
THYM	IUPHAR	MRPL16	PDE6D	0.810163757	1.31E-29
THYM	IUPHAR	MRPL16	IDH2	0.810569452	1.17E-29
THYM	IUPHAR	MRPL16	ADA	0.814560094	3.69E-30
THYM	IUPHAR	MRPL16	PPIA	0.819029729	9.85E-31
THYM	IUPHAR	MRPL16	RGS10	0.830901912	2.45E-32
THYM	IUPHAR	MRPL16	AURKB	0.830936331	2.42E-32
THYM	IUPHAR	MRPL16	NT5M	0.834077961	8.67E-33
THYM	IUPHAR	MRPL16	PADI4	0.844416706	2.53E-34
THYM	IUPHAR	MRPL16	VRK1	0.854936089	5.27E-36
THYM	Kinase	MRPL16	AURKB	0.830936331	2.42E-32
THYM	Kinase	MRPL16	VRK1	0.854936089	5.27E-36
THYM	TF	MRPL16	TIGD3	0.805314999	5.09E-29
THYM	TF	MRPL16	MAZ	0.814288287	4.00E-30
THYM	TF	MRPL16	THYN1	0.838257216	2.14E-33
THYM	TF	MRPL16	GTF3A	0.844886049	2.14E-34
THYM	TF	MRPL16	MXD3	0.849758585	3.67E-35
THYM	TSG	MRPL16	ANP32A	0.801061795	1.62E-28
THYM	TSG	MRPL16	HTRA2	0.806674861	3.49E-29
THYM	TSG	MRPL16	PTPN2	0.813994895	4.35E-30
THYM	TSG	MRPL16	MAL	0.826294665	1.06E-31
THYM	TSG	MRPL16	H2AFX	0.85527069	4.63E-36
UCS	Cell metabolism gene	MRPL16	ANP32A	0.801061795	1.62E-28
UCS	Cell metabolism gene	MRPL16	GNA15	0.802607149	1.07E-28
UCS	Cell metabolism gene	MRPL16	PFDN1	0.806722728	3.44E-29
UCS	Cell metabolism gene	MRPL16	PDE6D	0.810163757	1.31E-29
UCS	Cell metabolism gene	MRPL16	IDH2	0.810569452	1.17E-29
UCS	Cell metabolism gene	MRPL16	EXOSC1	0.813260407	5.39E-30
UCS	Cell metabolism gene	MRPL16	ADA	0.814560094	3.69E-30
UCS	Cell metabolism gene	MRPL16	PSMA6	0.824989339	1.60E-31
UCS	Cell metabolism gene	MRPL16	ZNRD1	0.826855631	8.89E-32
UCS	Cell metabolism gene	MRPL16	LSM5	0.827696319	6.82E-32
UCS	Cell metabolism gene	MRPL16	NT5M	0.834077961	8.67E-33
UCS	Cell metabolism gene	MRPL16	TUBA1B	0.838048882	2.30E-33
UCS	Cell metabolism gene	MRPL16	SEC61B	0.840010295	1.18E-33
UCS	Cell metabolism gene	MRPL16	SRP14	0.846381668	1.25E-34
UCS	Cell metabolism gene	MRPL16	SNRPF	0.858603437	1.27E-36
UCS	Cell metabolism gene	MRPL16	DUT	0.859597877	8.58E-37
UCS	Cell metabolism gene	MRPL16	GNG5	0.869000105	1.80E-38
UCS	Cell metabolism gene	MRPL16	SNRPG	0.898615403	9.37E-45
UCS	CGC	MRPL16	EWSR1	0.80372254	7.89E-29
UCS	CGC	MRPL16	CCND3	0.809270148	1.69E-29
UCS	CGC	MRPL16	IDH2	0.810569452	1.17E-29
UCS	CGC	MRPL16	U2AF1	0.846218969	1.33E-34
UCS	CGC	MRPL16	H3F3A	0.900234735	3.75E-45
UCS	Epifactor	MRPL16	HMGB1	0.80013192	2.09E-28
UCS	Epifactor	MRPL16	ANP32A	0.801061795	1.62E-28
UCS	Epifactor	MRPL16	CBX3	0.802684716	1.05E-28
UCS	Epifactor	MRPL16	H2AFY	0.804892365	5.72E-29
UCS	Epifactor	MRPL16	UBE2T	0.806975038	3.21E-29
UCS	Epifactor	MRPL16	PRR14	0.810346361	1.24E-29
UCS	Epifactor	MRPL16	HIST1H2BH	0.810669081	1.13E-29
UCS	Epifactor	MRPL16	EXOSC1	0.813260407	5.39E-30
UCS	Epifactor	MRPL16	MAZ	0.814288287	4.00E-30
UCS	Epifactor	MRPL16	HIST1H3F	0.815531368	2.78E-30
UCS	Epifactor	MRPL16	HIST2H2AC	0.817000196	1.80E-30
UCS	Epifactor	MRPL16	NASP	0.817111605	1.74E-30
UCS	Epifactor	MRPL16	ANP32B	0.828838829	4.74E-32
UCS	Epifactor	MRPL16	AURKB	0.830936331	2.42E-32
UCS	Epifactor	MRPL16	HMGN2	0.841008705	8.34E-34
UCS	Epifactor	MRPL16	PADI4	0.844416706	2.53E-34
UCS	Epifactor	MRPL16	H1FX	0.847324395	8.93E-35
UCS	Epifactor	MRPL16	PCNA	0.851804327	1.72E-35
UCS	Epifactor	MRPL16	VRK1	0.854936089	5.27E-36
UCS	Epifactor	MRPL16	H2AFX	0.85527069	4.63E-36
UCS	Epifactor	MRPL16	H2AFZ	0.859264229	9.79E-37
UCS	Epifactor	MRPL16	HIRIP3	0.874201368	1.85E-39
UCS	Epifactor	MRPL16	RBX1	0.885137856	1.11E-41
UCS	Epifactor	MRPL16	H3F3A	0.900234735	3.75E-45
UCS	IUPHAR	MRPL16	PVRIG	0.800998503	1.65E-28
UCS	IUPHAR	MRPL16	CD247	0.801028145	1.64E-28
UCS	IUPHAR	MRPL16	CD3E	0.803975033	7.36E-29
UCS	IUPHAR	MRPL16	PDE6D	0.810163757	1.31E-29
UCS	IUPHAR	MRPL16	IDH2	0.810569452	1.17E-29
UCS	IUPHAR	MRPL16	ADA	0.814560094	3.69E-30
UCS	IUPHAR	MRPL16	PPIA	0.819029729	9.85E-31
UCS	IUPHAR	MRPL16	RGS10	0.830901912	2.45E-32
UCS	IUPHAR	MRPL16	AURKB	0.830936331	2.42E-32
UCS	IUPHAR	MRPL16	NT5M	0.834077961	8.67E-33
UCS	IUPHAR	MRPL16	PADI4	0.844416706	2.53E-34
UCS	IUPHAR	MRPL16	VRK1	0.854936089	5.27E-36
UCS	Kinase	MRPL16	AURKB	0.830936331	2.42E-32
UCS	Kinase	MRPL16	VRK1	0.854936089	5.27E-36
UCS	TF	MRPL16	TIGD3	0.805314999	5.09E-29
UCS	TF	MRPL16	MAZ	0.814288287	4.00E-30
UCS	TF	MRPL16	THYN1	0.838257216	2.14E-33
UCS	TF	MRPL16	GTF3A	0.844886049	2.14E-34
UCS	TF	MRPL16	MXD3	0.849758585	3.67E-35
UCS	TSG	MRPL16	ANP32A	0.801061795	1.62E-28
UCS	TSG	MRPL16	HTRA2	0.806674861	3.49E-29
UCS	TSG	MRPL16	PTPN2	0.813994895	4.35E-30
UCS	TSG	MRPL16	MAL	0.826294665	1.06E-31
UCS	TSG	MRPL16	H2AFX	0.85527069	4.63E-36

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	MRPL16	MRPL15	-2.15546608137429	0.000334546435624361
KIRC	MRPL16	MRPL11	-1.04966837625557	0.000354478033746394
LIHC	MRPL16	MRPL13	1.54402472107614	0.000655351190157038
KIRP	MRPL16	MRPL19	-1.9689242575519	0.00179363833740354
ESCA	MRPL16	MRPL47	-2.26373711796715	0.001953125
CHOL	MRPL16	MRPL2	-1.49926301466752	0.00390625
COAD	MRPL16	MRPL15	1.17181689924568	0.00513318181037904
KICH	MRPL16	MRPL19	-2.18550705564541	0.00672554969787598
ESCA	MRPL16	MRPL13	-1.07746088474995	0.0068359375
COAD	MRPL16	MRPL47	-2.29582381838246	0.00863465666770936
STAD	MRPL16	MRPL47	-1.4008685687155	0.0118026207201183
STAD	MRPL16	MRPL4	1.4393539135682	0.0279771662317216
CHOL	MRPL16	MRPL19	-2.09295650388558	0.0390625
LIHC	MRPL16	MRPL47	-6.59586850948538	0.0416658979324166
KIRP	MRPL16	MRPL36	1.03588200500181	0.0433286507613957
BLCA	MRPL16	MRPL2	-3.29210657477178	0.0445594787597656
BLCA	MRPL16	MRPL22	-2.25969747792543	0.0493659973144531
KIRC	MRPL16	MRPL47	1.74758475364701	1.00533732476669e-06
LUAD	MRPL16	MRPL2	-1.26727646741024	1.07341296213058e-06
BRCA	MRPL16	MRPL36	-1.94167827329593	1.14465421352297e-11
BRCA	MRPL16	MRPL22	-2.3061823226724	1.15724909394453e-08
PRAD	MRPL16	MRPL11	1.12581653394628	1.15996224044503e-05
KICH	MRPL16	MRPL15	1.54522142310359	1.19209289550781e-07
LUSC	MRPL16	MRPL15	-4.43702988385305	1.91594862886626e-08
COAD	MRPL16	MRPL4	2.77705897514473	2.98023223876954e-07
LUAD	MRPL16	MRPL36	-3.29841702586724	3.01758810775006e-09
LUSC	MRPL16	MRPL40	-8.45997214407498	3.09303724812157e-05
BRCA	MRPL16	MRPL15	-3.82448964360727	5.49451113259074e-14
LUAD	MRPL16	MRPL22	-3.64343361732659	6.84976461567817e-06
LUSC	MRPL16	MRPL2	-2.66710222706783	7.24218086307245e-08
LUAD	MRPL16	MRPL47	-1.74990909879567	9.53955602455483e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL16

ICT1, Ybx1, MRPL15, MRPL40, MRPL38, MRPL11, MRPL13, MRPL22, MRPL2, MRPL14, MRPL19, MARCKSL1, MSLN, TMEM177, RBMS2, IQCB1, RPL13, HNRNPA1, MRPL28, RPS8, MRPL4, MRPL39, MRPL37, MRPS30, MRPL47, RPL23A, RPL9, RPS15A, MRPS7, AURKA, ANLN, MRPL50, MRPL9, MRPL1, C6orf203, NDUFS3, CDC14B, DHX32, MRPL10, MRPL41, MRPL42, MRPL12, RPL18, SNX11, HSPD1, CYLD, ATP5A1, LEO1, PSMD1, TAZ, RECQL4, RC3H2, NR2C2, SNRNP70, NFX1, PLEKHA4, ELK4, PXN, CANX, LOC102724334, nsp6, HSCB, RBM47, ARHGAP19, AUH, C12orf65, C1QBP, C21orf33, GFM1, HINT2, MDH2, METTL17, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, TACO1, TBRG4, TRUB2, TSFM, TUFM, EXD2, INS, LGALS9, DDRGK1, LAMP1, HNRNPU, RPL17, YBX1, RPL19, ABT1, MRPL30, MALSU1, MAGEA9, H1FNT, SRSF5, RPL3, YBX2, MRPL51, RPL37, MRPL53, RPL27A, GNL3, RPL26, SRSF4, RPS6, LIN28A, RPL13A, MRPL18, MRPL52, SRSF3, MRPL35, RPL31, RBMS3, RPL36AL, FTSJ2, RPL10, RPL35, AMACR, MRPS18A, HIST1H2AE, MRPL23, YARS2, MRPL27, NEIL1, FAHD1, MRPL46, MRPS25, GADD45GIP1, PRR3, FBXW7, FURIN, ACE2, E, M, nsp11, nsp12, nsp15, ORF10, ORF6, S, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPL16	chr11	59573957	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL16	LIHC	chr11	59575183	59575183	A	-	Frame_Shift_Del	p.F87fs	4
MRPL16	LUAD	chr11	59575233	59575233	C	T	Missense_Mutation	p.D71N	3
MRPL16	LUAD	chr11	59574080	59574080	G	A	Missense_Mutation	p.R166C	3
MRPL16	ESCA	chr11	59574020	59574020	C	T	Missense_Mutation	p.A186T	3
MRPL16	LIHC	chr11	59574151	59574151	C	-	Frame_Shift_Del	p.G143fs	3
MRPL16	PAAD	chr11	59573897	59573897	G	A	Missense_Mutation	p.R227W	3
MRPL16	BLCA	chr11	59578113	59578113	G	A	Missense_Mutation	p.R7C	2
MRPL16	ESCA	chr11	59574020	59574020	C	T	Missense_Mutation		2
MRPL16	UCEC	chr11	59577388	59577388	A	G	Missense_Mutation	p.W21R	2
MRPL16	CESC	chr11	59573980	59573980	C	T	Missense_Mutation		2
MRPL16	HNSC	chr11	59575303	59575303	T	G	Missense_Mutation	p.K47N	2
MRPL16	LUAD	chr11	59573868	59573868	G	T	Silent	p.T236T	2
MRPL16	STAD	chr11	59577343	59577343	C	G	Missense_Mutation		2
MRPL16	STAD	chr11	59577343	59577343	C	G	Missense_Mutation	p.V36L	2
MRPL16	STAD	chr11	59574011	59574011	C	T	Missense_Mutation	p.A189T	2
MRPL16	STAD	chr11	59575228	59575228	T	C	Missense_Mutation	p.I72M	2
MRPL16	LIHC	chr11	59574231	59574231	G	-	Frame_Shift_Del	p.P115fs	2
MRPL16	UCEC	chr11	59574260	59574260	G	A	Missense_Mutation	p.R106C	2
MRPL16	SARC	chr11	59577384	59577384	G	T	Missense_Mutation		1
MRPL16	BLCA	chr11	59575238	59575238	A	G	Missense_Mutation	p.L69S	1
MRPL16	SARC	chr11	59574243	59574243	G	T	Silent	p.R111R	1
MRPL16	HNSC	chr11	59578091	59578091	C	A	Missense_Mutation		1
MRPL16	LUAD	chr11	59573990	59573990	C	G	Missense_Mutation	p.E196Q	1
MRPL16	SKCM	chr11	59578100	59578100	G	A	Missense_Mutation	p.P11L	1
MRPL16	HNSC	chr11	59575303	59575303	T	G	Missense_Mutation		1
MRPL16	COAD	chr11	59573903	59573903	C	T	Missense_Mutation	p.G225S	1
MRPL16	SKCM	chr11	59575316	59575316	G	A	Missense_Mutation	p.S43F	1
MRPL16	COAD	chr11	59573970	59573970	T	C	Silent	p.Q202Q	1
MRPL16	KIRP	chr11	59573911	59573911	T	A	Missense_Mutation	p.N222I	1
MRPL16	LUAD	chr11	59577327	59577327	C	T	Splice_Site		1
MRPL16	COAD	chr11	59573981	59573981	G	A	Nonsense_Mutation	p.R199X	1
MRPL16	KIRP	chr11	59573937	59573937	C	G	Missense_Mutation	p.W213C	1
MRPL16	LUSC	chr11	59574004	59574004	C	G	Missense_Mutation	p.S191T	1
MRPL16	COAD	chr11	59573984	59573984	T	C	Missense_Mutation	p.M198V	1
MRPL16	LIHC	chr11	59575183	59575183	A	-	Frame_Shift_Del	p.A88fs	1
MRPL16	LUSC	chr11	59574276	59574276	G	T	Silent	p.G100G	1
MRPL16	ESCA	chr11	59577339	59577339	G	T	Missense_Mutation	p.P37Q	1
MRPL16	THYM	chr11	59574277	59574277	C	T	Missense_Mutation	p.G100D	1
MRPL16	BLCA	chr11	59578113	59578113	G	A	Missense_Mutation		1
MRPL16	PRAD	chr11	59573832	59573832	G	T	Silent	p.P248P	1
MRPL16	ESCA	chr11	59577339	59577339	G	T	Missense_Mutation		1
MRPL16	UCEC	chr11	59574061	59574061	A	T	Missense_Mutation	p.V172E	1
MRPL16	BLCA	chr11	59575238	59575238	A	G	Missense_Mutation		1
MRPL16	SARC	chr11	59574243	59574243	G	T	Silent		1
MRPL16	ESCA	chr11	59573999	59573999	C	T	Missense_Mutation		1
MRPL16	LIHC	chr11	59575261	59575261	T	-	Frame_Shift_Del	p.K61fs	1

Copy number variation (CNV) of MRPL16
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL16
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
29496	N/A	CB163511	AR	chrX	66949475	-	MRPL16	chr11	59573715	-
29505	N/A	BM990847	FAU	chr11	64888170	+	MRPL16	chr11	59574306	-
54927	N/A	AX340435	MRPL16	chr11	59573613	-	LINC00922	chr16	65365149	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPL16	0.000663966326891812	0.019

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	MRPL16	0.0125584506769964	0.39
KIRP	MRPL16	0.0163984862748588	0.49
BRCA	MRPL16	0.036940881629306	1
PAAD	MRPL16	0.00163403212347581	0.054
THYM	MRPL16	0.00318045438619653	0.1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source